The value of interferon drops for children with respiratory infections. Contraindications and side effects. Use during pregnancy

It comes in several types, but drugs based on the protein interferon alpha are characterized by the highest bioavailability.

Release form of Interferon Alpha

There are quite a few ways to use the medicine, so the release is pharmacologically justified various forms medications:

• dry powder used for injection in combination with distilled water;
• ready solution for injection;
• rectal suppositories;
• ointment;
• nasal drops;
• nasal spray;
• eye drops;
• dry powder for the preparation of nasal and eye drops.

Application of Interferon Alpha

Treatment with Interferon Alpha is based on a high antiviral effect. It has long been noted that a person in whose body one virus develops cannot become infected with a virus of another type. When interferon is administered, cells into which the virus has not yet penetrated become resistant to it and over time the disease goes away. Since this scheme is suitable for viruses of any type, the scope of application of Interferon Alpha is very wide:

• viral hepatitis of any type;
• conjunctivitis;
• nasal and ophthalmic infections;
• ARVI, influenza;
• laryngeal pipillomatosis;
• multiple myeloma;
• leukemia;
• Kaposi's sarcoma;
• lymphoma;
• carcinoma;
• viral and bactericidal-viral infections of any type in children.

Unlike other antiviral drugs of synthetic origin, interferon has few contraindications. It is used with caution for problems with the excretory organs and some liver diseases. During pregnancy and lactation, the drug is taken strictly as prescribed by the doctor. The side effects of Interferon Alpha cannot be called pleasant, but they occur rarely. This:

It is also important to know that this medicine does not combine very well with other pharmacological and medicinal agents, so you should consult your physician about the use of each of them. This will help avoid serious complications. It is most undesirable to take interferon together with sedatives and narcotic drugs.

How to dilute Interferon Alpha powder depends on your goals. The required dose of the medicine must first be diluted with distilled water for injection in an amount of 50 ml. If you need drops in the nose or eyes, you can also use saline solution (sodium chloride) for these purposes.

Interferon Alpha eye drops and other types of medicine are ready for use and do not require the addition of additional components.

Analogues of the drug Interferon Alpha

Today, there are many drugs based on various interferons. Some of them are imported, others are domestic, but the degree of effectiveness of all these drugs is approximately the same. The only difference is the quality of protein purification and, hence, the price. Here is a list of medications that can replace Interferon Alpha:

• Alfarekin;
• Intron A;
• Roferon;
• Nazoferon;
• Wellveron;
• human leukocyte interferon and others.

All these drugs are designed to treat the manifestations of various viruses, block their spread throughout the body, prevent infection of new cells, strengthening the cell membrane. Thanks to the synthesis of special types of enzymes, the body strengthens the immune system and begins to independently fight infection. Also, interferons of all types have an antitumor effect, the reasons for which have not been precisely established to date, but the use of the drug for treatment and prevention oncological diseases not prohibited.

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Interferon: application features, composition, indications, analogues

Today's pharmacology represents a large assortment medicines that have large spectrum useful properties in the treatment of viruses and infections. One of these drugs is Interferon. Before use, please read the indications and contraindications in detail. of this medicine.

Composition, release form and manufacturer

Interferon is a drug consisting of a mixture of various natural alpha interferons. Interferon inducers are obtained from human blood leukocytes. It has several release forms:

• Lyophysiate (dried drug, frozen, later used to obtain a solution)
• Ampoules 2 ml
• Suppositories for rectal and vaginal use
• Solution for injections or inhalations
• Powder for making drops
• Aerosol
• Microclysters
• Pills

There are several companies that produce Interferon; they are located in the United States of America, the Russian Federation, Israel, Switzerland and other countries.

Indications for use of Interferon

Interferon belongs to the group of antiviral and immunomodulatory drugs. Their work is aimed at stimulating the work of cells responsible for the formation cellular immunity. The product is intended for the treatment of:

It is also used to prevent acute respiratory infections and influenza. Interferon has also received widespread use for the treatment of cancer tumors. lymphatic system, kidney, gastrointestinal tract, blood cancer. It is also prescribed for the treatment of pathologies of nerve tissue and the spinal cord.

Contraindications

The main contraindications of Interferon are indicated in the instructions for use. These include:

• Severe heart disease
• Problems in the functioning of the kidneys and liver
• Personal intolerance to the component composition
• Cirrhosis
• Epilepsy
• Diseases of the central nervous system
• Problems with the thyroid gland

The drug should not be given to children who were born prematurely or were born before 34 weeks of gestation. Contraindicated in case of unclosed intestinal bleeding. Particular caution should be exercised during pregnancy or lactation. The dosage and regimen of taking the drug should be agreed with your doctor.

Mechanism of action of the drug

The main effect of Interferon is to inhibit the synthesis of viral proteins. The fight against the virus begins within a few hours after taking the medicine. The drug does not penetrate into the cell, but acts on membranes, coming into contact with specific receptors.

The following effects occur on the body:

In the first case, the process of inhibiting the reproduction of viral cells occurs. In the second, the drug’s work is possible due to the content of the p53 protein. Regardless of the form of release and administration into the body, Interferon has 100% bioavailability, that is, it is completely absorbed by the body.

For more information about the use of Interferon, watch our video:

Instructions for use

The daily dosage and form of the drug used are determined by the doctor depending on the patient’s age, his diagnosis and the presence of concomitant pathologies.

For preventive purposes, Interferon against influenza or similar infections is used 4-5 times a week.

The most optimal form of release for this purpose is nasal drops for the nose. It is enough to drop 2 drops into each nostril.

If you use Interferon lyophysiate, then before injection you should dilute it in 2 ml of water. A similar method of use is suitable for diluting the medicine as a solution for inhalation.

The prepared solution should be stored for no more than a day. Suppositories are prescribed for the treatment of herpes and papillomavirus. 1-2 times a day, suppositories are administered rectally or vaginally for a course of no more than 10 days.

In the treatment of cancer, the medicine is administered intramuscularly. The dosage in each case is determined individually. When undergoing a course of chemical or radiation therapy, Interferon should be taken for another 14 days after completion.

Used for eye diseases eye drops(2 pieces in each eye) Interferon. The daily dosage of instillation is no more than 6 times. When symptoms decrease, the dosage is halved. The permissible duration of the course is 1-1.5 weeks.

The ointment is used to prevent ARVI. The nasal passages should be lubricated with it twice a day for 1-3 weeks. Interferon in tablets can be taken no more than 2050 IU per kilogram of the patient’s weight. The total dosage should not exceed 1 million IU. The sooner a course of treatment or prevention with Interferon is started, the higher the effectiveness of the drug will be.

How to prepare Interferon solution for instillation into the nose, see our video:

Side effects

When taking Interferon, no one is immune from adverse drug reactions. Most often, their manifestation occurs in the first 2 weeks of use. With further continuation of the course, the symptoms of side effects subside. The most common body reactions to Interferon are:

1. Severe headaches
2. Temperature rises to 38 degrees
3. Fever
4. Muscle pain
5. Joint pain
6. General malaise

Additionally, disturbances in the functioning of the digestive, cardiovascular and nervous systems, allergies, and problems with the functioning of the respiratory system may appear.

Use during pregnancy

The use of Interferon during pregnancy and lactation is carried out under the supervision and with the permission of the attending physician. There are no registered cases of the drug having a negative effect on the development of the fetus and the body of the expectant mother.

When using the drug by a nursing mother, the baby's reaction should be observed. Interferon passes into breast milk in small concentrations, so an ambiguous baby’s reaction to it will be a reason to refuse the medicine.

Overdose

No cases of overdose with Interferon have been identified. To prevent the development of adverse reactions, do not exceed the dosage prescribed by the doctor or instructions in accordance with the patient’s age.

Drug interactions

Caution should be exercised when using Interferon with other non-steroidal anti-inflammatory drugs due to the possible likelihood of additional stress on the liver. This is especially true for patients with organ dysfunction. In this case, the course of treatment is carried out under constant medical supervision.

special instructions

When prescribing Interferon, it is necessary to ensure that the patient does not have problems with work of cardio-vascular system. It is not recommended for people who have recently had a heart attack.

For thrombocytopenia, the drug is administered strictly under the skin.

For people over 65 years of age, the dosage is selected individually.

Interferon rectal suppositories are contraindicated in case of exacerbation of hemorrhoids or bleeding of its nodes. Suppositories are not prescribed for the external form of the disease.

Reviews about the drug

Interferon is recommended by 9 out of 10 patients. Reviews about the drug are mostly positive. It helps not only adults and children. The drug also helps strengthen children's immunity and resist infections in the body.

Reviews from Dr. Komarovsky about the use of Interferon:

Interferon price

The cost of Interferon directly depends on the form of the drug, the volume of packaging and the manufacturer (to a lesser extent). The medicine in the form of a lyophilisate costs within rubles, a solution for intramuscular administration from 1100 rubles, for inhalation from 120 rubles.

Analogs

Interferon analogues are prescribed if the use of the drug itself is impossible due to personal intolerance or its use has caused severe adverse reactions.

Instead of medicine you can use the following drugs from the list:

Drug synonyms

Anaferon has a similar therapeutic effect of Interferon. The average cost of this medicine varies from 200 rubles per package. It is produced in the form of tablets intended for resorption. Used for the treatment and prevention of influenza and acute respiratory infections.

Conditions for dispensing from pharmacies

The drug is sold in pharmacies without a prescription. It should be stored in a cool place at a temperature of no more than 8 degrees and not lower than 2. Refers to drug group B.

Best before date

Shelf life – 2 years. The prepared solution should be stored for no more than 24 hours.

How to dilute interferon in ampoules for inhalation?

Interferon, which comes in ampoules, can be used for inhalation, eye drops for viral conjunctivitis, and nasal drops. The powder in the ampoule dissolves in water instantly. I use the most ordinary boiled and cooled water.

At the same time, it must be really cool, since Interferon does not tolerate high temperature. That's why it is stored in the refrigerator.

Add clean water directly to the ampoule up to the 2 ml mark and shake thoroughly. The grains will quickly and easily dissolve and you can inhale. It is usually recommended to use 5 drops in each nostril. During illness, once every two hours, for prevention - less often.

But personally, I didn’t notice much difference in my family without and with feron group drugs. Better strengthen your immune system natural means- follow a routine, eat normally and lead an active life. Then the body will have enough of its own living immunity, and not powder.

Interferon in ampoules is used for acute respiratory viral infections. If you inhale with Interferon using a nebulizer or inhaler, then it can be diluted with saline solution - 1 ampoule of Interferon powder per 5 ml of saline solution or with water - 3 ampoules per 10 ml of warm water (approximately 37 degrees). Inhalations cannot be performed more than twice. When our baby was prescribed inhalations, we did not use Interferon, but replaced it with Rotokan - it is made from medicinal herbs.

I've always played the usual trick boiled water, that’s what the doctor advised. To be sure, you can dilute it with sterile saline solution (sold at any pharmacy for pennies), but for inhalations this does not play a special role.

It is usually diluted with cold boiled water. You can buy distilled water at the pharmacy and dilute it with it. It is advisable to immediately use the solution for treatment. Can be stored for no more than 4 hours in a sterile syringe in the refrigerator.

Interferon

Prices in online pharmacies:

Interferon is a drug that helps increase immune defense body.

Available in the form of lyophilized powder for injection, liquid solution and rectal suppositories.

Pharmacological action of Interferon

In accordance with the instructions for Interferon, 1 ampoule of dry lyophilized powder contains a mixture of various types of natural alpha interferon of human blood leukocytes 1000 IU.

The composition of 1 ml liquid solution of Interferon Alpha includes a mixture of subtypes of natural alpha interferon from donated blood person 1000IU.

1 Interferon suppository contains a mixture of different types of natural alpha interferon of human blood leukocytes 40,000 IU.

The instructions for Interferon indicate that the drug is one of the factors (protein) produced by the body that prevents the body from being damaged by viral infections.

Human interferon is a group of endogenous proteins that are produced by leukocytes of human donor blood under the influence of various viruses.

Interferon Alpha is a highly purified sterile protein containing 165 amino acids. The drug is created by genetic engineering, through recombinant DNA. The drug has an antitumor effect. When using Interferon, fluctuations in the concentration of the active substance of the drug in the blood serum are observed.

This drug has antiviral, immunostimulating and antiproliferative activity.

The antiviral effect is due to an increase in the resistance of body cells free from viral infections to possible influences. Due to binding to specific receptors located on the surface of the cell, the active substance of the drug changes the properties of the cell membrane, while stimulating specific enzymes; affects the RNA of the virus, due to which it blunts its replication.

The immunostimulating effect of human interferon in all forms of release is due to stimulation of the activity of NK cells and macrophages, which take part in the body's immune response to tumor cells.

The drug is excreted from the body through the kidneys.

Interferon is effectively used for children and adults.

Indications for use

Interferon Alpha is prescribed for the treatment of Kaloshi's sarcoma (a disease vascular bed skin, which is accompanied by new formation of blood vessels, their bulging and proliferation) in patients with AIDS, as well as for the treatment of leukemic reticuloendotheliosis, kidney cancer and Bladder, melanoma, herpes zoster.

Human interferon is used to treat chronic and acute viral hepatitis (inflammation of liver tissue caused by a virus). The use of Interferon in the form of suppositories as part of therapy is effective hemorrhagic fever with renal syndrome.

Local application (in the nose or eyes) of Interferon solution is prescribed for children and adults for the prevention and treatment of influenza, ARVI, conjunctivitis, keratouveitis and keratitis.

Directions for use and dosage

Interferon is used in the form of a solution prepared from boiled or distilled water at room temperature. To do this, pour water into the opened ampoule up to the mark that corresponds to 2 ml. After this, the ampoule must be shaken until the powder is completely dissolved. After dilution, the solution becomes red in color; it should be stored in a cool place for no more than 48 hours. 5 drops of solution should be administered into each nasal passage 2 times a day. The interval between use is at least 6 hours.

The most effective is inhalation method use of Interferon. To do this, the contents of 3 ampoules should be dissolved in 10 ml of water and heated to a temperature not exceeding 37 degrees. The frequency of procedures is 2 times a day. Duration of treatment is 2-3 days.

For the treatment of acute respiratory viral infections, according to the instructions, Interferon must be used when the first signs of the disease appear.

Before starting treatment with Interferon Alpha, the susceptibility of the microflora that caused the disease should be determined. For the treatment of leukemic reticuloendotheliosis, an initial dose of BME is prescribed for daily subcutaneous or intramuscular administration for 4-6 months. The maintenance dose is equal to IU for intramuscular administration 3 times a week. Treatment must be carried out under the supervision of the attending physician.

For the treatment of Galoshi's sarcoma in patients with AIDS, an initial dose of ME is prescribed intramuscularly. Duration of therapy is 2-3 months. A maintenance dose of ME is administered daily 3 times a week.

The course of therapy with Interferon rectal suppositories should not exceed 15 days. The dose of the drug is prescribed individually and adjusted by the attending physician.

Side effects of Interferon

During the use of the drug, the following may occur: side effects, such as headaches and muscle pain, lethargy, fever, sweating, vomiting, dry mouth, diarrhea, loss of appetite and weight, flatulence, constipation, nausea, heartburn, liver dysfunction, hepatitis.

The active substance included in Interferon in all forms of release can cause visual impairment, sleep disturbances, depression, increased peristalsis, itching, skin rash, ischemic retinopathy, dizziness, nervousness, and joint pain.

Contraindications for use

Interferon of all forms is not prescribed to patients who have:

• Severe heart disease;
• Impaired functions of the kidneys, liver and central nervous system;
• Epilepsy;
• Cirrhosis of the liver;
• Chronic and autoimmune hepatitis;
• Thyroid diseases;
• Hypersensitivity to the components of the drug.

Overdose

In case of an overdose of Interferon, allergic reactions may occur on the part of the body, accompanied by skin rash, hives, itching, peeling of the skin, redness.

Additional Information

Take with caution medicine simultaneously with opioid analgesics, sedatives and hypnotics.

The instructions for Interferon indicate that the drug must be stored in a dark, cool, dry place out of reach of children. The shelf life of the powder for preparing the solution is 1 year, the liquid solution is 2 years, and the candles are 2 years.

Dispensed from pharmacies with a doctor's prescription.

Interferon human leukocyte 1000IU No. 10 ampoules

Interferon leukocyte person N10

Interferon human leukocyte liquid 1000IU/ml 5ml No. 1 bottle

Human leukocyte interferon liquid solution 1000 IU/ml 5 ml

Interferon beta-1b solution 8 million IU/ml 0.5 ml 5 pcs.

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Interferon

Description current as of 11/11/2014

• Latin name: Interferon
• ATX code: L03AB
• Active ingredient: In interferon preparations the following can be used as an active component: human α, β or γ interferon (IFN)
• Manufacturer: Hoffmann-La Roche, Switzerland; Schering-Plough, USA; InterMune, USA, etc.

Compound

The composition of interferon preparations depends on their release form.

Release form

Interferon preparations have the following release forms:

• lyophilized powder for the preparation of eye and nasal drops, injection solution;
• injection solution;
• eye drops;
• eye films;
• nasal drops and spray;
• ointment;
• dermatological gel;
• liposomes;
• aerosol;
• oral solution;
• rectal suppositories;
• vaginal suppositories;
• implants;
• microenemas;
• tablets (interferon tablets are available under the brand name Entalferon).

pharmachologic effect

IFN drugs belong to the group of drugs with antiviral and immunomodulatory effects.

All IFNs have antiviral and antitumor effects. No less important is their property of stimulating macrophages, cells that play an important role in the initiation of cellular immunity.

IFNs help increase the body's resistance to the penetration of viruses, and also block the reproduction of viruses when they penetrate the cell. The latter is due to the ability of IFN to suppress the translation of the messenger RNA of the virus.

However, the antiviral effect of IFN is not directed against specific viruses, that is, IFNs are not characterized by virus specificity. This is precisely what explains their versatility and wide range of antiviral activity.

Pharmacodynamics and pharmacokinetics

Main biological effectα-IFN inhibits the synthesis of viral proteins. The antiviral state of the cell develops within several hours after administration of the drug or induction of IFN production in the body.

At the same time, IFN does not affect the early stages of the replication cycle, that is, at the stage of adsorption, penetration of the virus into the cell (penetration) and release internal component the virus in the process of “undressing”.

The antiviral effect of α-IFN occurs even when cells are infected with infectious RNA. IFN does not penetrate the cell, but only interacts with specific receptors on cell membranes (gangliosides or similar structures that contain oligosugars).

The mechanism of IFN alpha activity resembles the action of individual glycopeptide hormones. It stimulates the activity of genes, some of which are involved in encoding the formation of products with a direct antiviral effect.

β interferons also have an antiviral effect, which is associated with several mechanisms of action. Beta interferon activates NO synthetase, which in turn increases the concentration of nitric oxide inside the cell. The last one plays key role in suppressing the reproduction of viruses.

β-IFN activates the secondary, effector functions of natural killer cells, B-type lymphocytes, blood monocytes, tissue macrophages (mononuclear phagocytes) and neutrophil leukocytes, which are characterized by antibody-dependent and antibody-independent cytotoxicity.

In addition, β-IFN blocks the release of the internal component of the virus and disrupts the processes of RNA methylation of the virus.

γ-IFN is involved in the regulation of the immune response and regulates the severity of inflammatory reactions. Despite the fact that it has an independent antiviral and antitumor effect, gamma interferon is very weak. At the same time, it significantly enhances the activity of α- and β-IFN.

After parenteral administration the maximum concentration of IFN in the blood plasma is observed after 3-12 hours. The bioavailability indicator is 100% (both after injection under the skin and after injection into the muscle).

The half-life T½ ranges from 2 to 7 hours. Trace concentrations of IFN in blood plasma are not detectable after 16–24 hours.

Indications for use

IFN is intended to treat viral diseases affecting the respiratory tract.

In addition, interferon preparations are prescribed to patients with chronic forms of hepatitis B, C and Delta.

For the treatment of viral diseases and, in particular, hepatitis C, IFN-α is used predominantly (both of its forms - IFN-alpha 2b and IFN-alpha 2a). Pegylated interferons alpha-2b and alpha-2a are considered to be the “gold standard” for the treatment of hepatitis C. In comparison, conventional interferons are less effective.

Genetic polymorphism observed in the IL28B gene, which is responsible for encoding IFN lambda-3, causes significant differences in the effect of treatment.

Patients with genotype 1 hepatitis C with common alleles of this gene are more likely to achieve longer and more pronounced treatment results compared to other patients.

Contraindications

Interferon is not prescribed to patients with hypersensitivity to it, as well as to children and adolescents suffering from severe mental disorders and disorders of the nervous system, which are accompanied by thoughts of suicide and suicide attempts, severe and prolonged depression.

In combination with the antiviral drug Ribavirin, IFN is contraindicated in patients diagnosed with serious violations in kidney function (conditions in which CC is less than 50 ml/min).

Interferon drugs are contraindicated in epilepsy (in cases where appropriate therapy does not give the expected clinical effect).

Side effects

Interferon belongs to the category of drugs that can cause a large number of adverse reactions from various systems and organs. In most cases, they are a consequence of the administration of interferon intravenously, subcutaneously or intramuscularly, but they can also be provoked by other pharmaceutical forms of the drug.

The most common adverse reactions to taking IFN are:

Somewhat less common are vomiting, increased drowsiness, dry mouth, hair loss (alopecia), asthenia; nonspecific symptoms flu-like symptoms; back pain, depressive conditions, musculoskeletal pain, thoughts of suicide and attempted suicide, general malaise, impaired taste and concentration, increased irritability, sleep disorders (often insomnia), arterial hypotension, confusion.

Rare side effects include: pain in the right upper abdomen, rashes on the body (erythematous and maculopapular), increased nervousness, soreness and severe inflammation at the injection site of the drug, secondary viral infection (including infection with the herpes simplex virus), increased dryness of the skin, itching, pain in the eyes, conjunctivitis, blurred vision, dysfunction of the lacrimal glands, anxiety, mood lability; psychotic disorders, including hallucinations, increased aggression, etc.; hyperthermia, dyspeptic symptoms, respiratory disorders, weight loss, tachycardia, loose stools, myositis, hyper- or hypothyroidism, hearing impairment (up to complete loss), formation of infiltrates in the lungs, increased appetite, bleeding gums, cramps in the limbs, dyspnea, impaired renal function and development of renal failure, peripheral ischemia, hyperuricemia, neuropathy, etc.

Treatment with IFN drugs may cause reproductive dysfunction. Studies in primates have shown that interferon disrupts the menstrual cycle in women. In addition, in women treated with IFN-α drugs, serum estrogen and progesterone levels decreased.

For this reason, if interferon is prescribed to women childbearing age should be used barrier agents contraception. Men reproductive age It is also recommended to be informed about potential side effects.

IN in rare cases interferon treatment may be accompanied by ophthalmological disorders, which are expressed in the form of hemorrhages in the retina, retinopathy (including macular edema), focal changes in the retina, decreased visual acuity and/or limitation of visual fields, swelling of the optic discs, ocular neuritis (second cranial neuritis). ) nerve, obstruction of the retinal arteries or veins.

Sometimes, while taking interferon, hyperglycemia and symptoms of nephrotic syndrome, diabetes, and renal failure can develop. In patients with diabetes mellitus the clinical picture of the disease may worsen.

The use of interferon in monotherapy or in combination with Ribavirin in isolated cases can provoke aplastic anemia (AA) or even PRACM (complete aplasia of the red bone marrow).

There have also been cases where, during treatment with interferon drugs, a patient developed various autoimmune and immune-mediated disorders (including Werlhof's disease and Moschkowitz's disease).

Interferon, instructions for use

The instructions for the use of alpha, beta and gamma interferons indicate that before prescribing the drug to a patient, it is recommended to determine how sensitive the microflora that caused the disease is to it.

The method of administration of human leukocyte interferon is determined depending on the diagnosis given to the patient. In most cases it is prescribed in the form subcutaneous injections, but in some cases the drug can be injected into a muscle or vein.

The treatment dose, maintenance dose and duration of treatment are determined depending on the clinical situation and the patient’s response to the therapy prescribed to him.

“Children’s” interferon is suppositories, drops and ointment.

Instructions for the use of interferon for children recommend using this drug both as a therapeutic and as a prophylactic agent. The dose for infants and older children is selected by the attending physician.

For preventive purposes, INF is used in the form of a solution, for the preparation of which distilled or boiled water at room temperature is used. The finished solution is colored red and opalescent. It should be stored in the cold for no more than an hour. The drug is instilled into the nose of children and adults.

For viral ophthalmological diseases the drug is prescribed in the form of eye drops.

As soon as the severity of the symptoms of the disease decreases, the volume of instillations should be reduced to one drop. The course of treatment is from 7 to 10 days.

To treat lesions caused by herpes viruses, a thin layer of ointment is applied to the affected areas of the skin and mucous membranes twice a day, maintaining 12-hour intervals. The course of treatment is from 3 to 5 days (until the integrity of the damaged skin and mucous membranes is completely restored).

To prevent acute respiratory infections and flu, it is necessary to lubricate the nasal passages with ointment. The frequency of procedures during the 1st and 3rd weeks of the course is 2 times a day. It is recommended to take a break during the 2nd week. For preventive purposes, interferon should be used throughout the entire period of the epidemic of respiratory diseases.

The duration of the rehabilitation course for children who often experience recurrent viral-bacterial infections of the respiratory tract, ENT organs, and recurrent infection caused by the herpes simplex virus is two months.

How to dilute and how to use interferon in ampoules?

The instructions for using interferon in ampoules indicate that before use, the ampoule must be opened, water (distilled or boiled) at room temperature must be poured into it up to the mark on the ampoule corresponding to 2 ml.

The contents are gently shaken until completely dissolved. The solution is injected into each nasal passage twice a day, five drops, maintaining intervals of at least six hours between administrations.

For therapeutic purposes, IFN is started when the first symptoms of influenza appear. The earlier the patient starts taking it, the higher the effectiveness of the drug.

The inhalation method (through the nose or mouth) is considered the most effective. For one inhalation, it is recommended to take the contents of three ampoules of the drug, dissolved in 10 ml of water.

The water is preheated to a temperature of no more than +37 °C. Inhalation procedures are carried out twice a day, maintaining an interval of at least one to two hours between them.

When sprayed or instilled, the contents of the ampoule are dissolved in two milliliters of water and 0.25 ml (or five drops) is administered into each nasal passage three to six times a day. Duration of treatment days.

Nasal drops for children for preventive purposes are instilled (5 drops) twice a day, for initial stage development of the disease, the frequency of instillations increases: the drug should be administered at least five to six times a day every hour or two.

Many people are interested in whether interferon solution can be dripped into the eyes. The answer to this question is yes.

Overdose

Cases of interferon overdose have not been described.

Interaction

β-IFN is compatible with corticosteroid drugs and ACTH. It should not be taken during treatment with myelosuppressive drugs, incl. cytostatics (this may cause an additive effect).

Beta-IFN is prescribed with caution with drugs whose clearance is largely dependent on the cytochrome P450 system (anti-epileptic drugs, some antidepressants, etc.).

You should not take α-IFN and Telbivudine at the same time. The simultaneous use of α-IFN provokes a mutual enhancement of action against HIV. When used together with phosphazide, the myelotoxicity of both drugs may mutually increase (it is recommended to carefully monitor changes in the number of granulocytes and hemoglobin levels).

Terms of sale

A prescription is required to dispense the drug.

Storage conditions

Interferon is stored in a cool place, protected from sunlight, at a temperature of +2 to +8°C. List B.

Best before date

24 months. The prepared interferon solution remains stable for 3 days at room temperature.

special instructions

Interferons are a class of glycoproteins with similar properties that are produced by vertebrate cells in response to the influence of various types of inducers, both viral and non-viral in nature.

According to Wikipedia, in order for a biologically active substance to be qualified as an interferon, it must be of a protein nature and have pronounced antiviral activity against various viruses, at least in homologous (similar) cells, “mediated by cellular metabolic processes, including the synthesis of RNA and protein "

The classification of IFNs proposed by the WHO and the Interferon Committee is based on differences in their antigenic, physical, chemical and biological properties. In addition, it takes into account their species and cellular origin.

Based on antigenicity (antigen specificity), IFNs are usually divided into acid-stable and acid-labile. The acid-fast ones include alpha and beta interferons (they are also called type I IFN). Interferon gamma (γ-IFN) is acid labile.

α-IFN is produced by peripheral blood leukocytes (B- and T-type leukocytes), so it was previously designated as leukocyte interferon. There are currently at least 14 varieties of it.

β-IFN is produced by fibroblasts and is therefore also called fibroblastic.

The previous designation of γ-IFN is immune interferon; it is produced by stimulated T-type lymphocytes, NK cells (normal (natural) killer cells; from the English “natural killer”) and (presumably) macrophages.

Basic properties and mechanism of action of IFN

Without exception, all IFNs are characterized by multifunctional activity against target cells. Their most common property is the ability to induce an antiviral state in them.

Interferon is used as a therapeutic and prophylactic agent for various viral infections. A feature of IFN drugs is that their effect weakens with repeated injections.

The mechanism of action of IFN is related to its ability to control viral infections. As a result of treatment with interferon drugs, a kind of barrier of uninfected cells resistant to the virus is formed in the patient’s body around the source of infection, which prevents the further spread of infection.

By interacting with still undamaged (intact) cells, it prevents the implementation of the reproductive cycle of viruses due to the activation of certain cellular enzymes (protein kinases).

The most important functions of interferons are considered to be the ability to suppress hematopoiesis; modulate the body's immune response and inflammation response; regulate the processes of cell proliferation and differentiation; suppress the growth and prevent the proliferation of viral cells; stimulate the expression of surface antigens; suppress individual functions of B- and T-type leukocytes, stimulate the activity of NK cells, etc.

Use of IFN in biotechnology

The development of methods for the synthesis and highly efficient purification of leukocyte and recombinant interferons in quantities sufficient for the production of drugs has opened up the possibility of using IFN drugs for the treatment of patients diagnosed with viral hepatitis.

A distinctive feature of recombinant IFNs is that they are obtained outside human body.

For example, recombinant interferon beta-1a (IFN β-1a) is obtained from mammalian cells (in particular, from Chinese hamster ovary cells), and interferon beta-1b (IFN β-1b), similar in its properties, is produced by belonging to family of enterobacteriaceae coli(Escherichia coli).

Interferon inducer drugs - what are they?

IFN inducers are drugs that do not themselves contain interferon, but at the same time stimulate its production.

Analogs

Each type of interferon has analogues. Interferon alpha-2a preparations - Reaferon, Roferon. Recombinant human interferon alpha 2b is produced under the trademarks Intron-A, Intrek, Viferon.

Interferon for children

According to the instructions, interferon preparations are indicated for children:

IFN is also used in therapy, the purpose of which is the rehabilitation of children who often suffer from respiratory infections.

The most optimal option for children is nasal drops: when used in this way, interferon does not penetrate the gastrointestinal tract (before diluting the drug for the nose, the water should be heated to a temperature of 37°C).

For infants, interferon is prescribed in the form of suppositories (150 thousand IU). Suppositories for children should be administered one at a time 2 times a day, maintaining 12-hour intervals between administrations. The course of treatment is 5 days. To completely cure ARVI in a child, as a rule, one course is enough.

For treatment, you should take 0.5 g of ointment twice a day. Treatment lasts on average 2 weeks. Over the next 2-4 weeks, the ointment is used 3 times a week.

Numerous positive reviews of the drug indicate that in this dosage form it has also established itself as an effective remedy for the treatment of stomatitis and inflamed tonsils. Interferon inhalations for children are no less effective.

The effect of using the drug increases significantly if a nebulizer is used to administer it (it is necessary to use a device that sprays particles with a diameter of more than 5 microns). Inhalations through a nebulizer have their own specifics.

First, interferon must be inhaled through the nose. Secondly, before using the device, you must turn off the heating function (IFN is a protein; at temperatures above 37°C it is destroyed).

For inhalation in a nebulizer, the contents of one ampoule are diluted in 2-3 ml of distilled or mineral water (saline solution can also be used for these purposes). The resulting volume is enough for one procedure. The frequency of procedures during the day is from 2 to 4.

It's important to remember that long-term treatment Interferon is not recommended for children, since addiction develops to it and, therefore, the expected effect does not develop.

Interferon during pregnancy

An exception may be cases when the expected benefit of therapy for the expectant mother exceeds the risk of adverse reactions and harmful effects on fetal development.

The possibility of isolating recombinant IFN components in breast milk cannot be ruled out. Due to the possibility of exposure to the fetus through milk, IFN is not prescribed to nursing women.

As a last resort, when the administration of IFN cannot be avoided, the woman is advised not to breastfeed during therapy. To mitigate the side effects of the drug (the occurrence of symptoms similar to those of influenza), simultaneous administration of paracetamol with IFN is recommended.

Interferon is a specific protein of the human immune system that is produced in response to viruses entering the body. different types. It protects cells from introducing an infectious agent into them and prevents the replication (copying) of viruses. The pharmaceutical industry has created a broad-spectrum drug that is a group of proteins with antiviral properties. Interferon for children is actively used in pediatric practice, since it is absolutely non-toxic, does not have a negative effect on the functioning of internal organs and systems, and has no serious contraindications.

The mechanism of action of immune proteins on the child’s body

The main purpose of Interferon is to prevent viruses from infecting healthy cells. The drug makes the body immune to infection. Human interferon is formed as a response to the penetration of pathogenic flora.

After a cell is infected with a virus, active production of the microbe begins. At the same time, a specific protein, interferon, is intensively produced. It is released through the membrane and comes into contact with neighboring healthy cells, changing their biochemical composition. This prevents intracellular processes such as viral replication, the formation of viral particles, and the spread of infection throughout the body.

The action of Interferon is directed along several vectors:

• under the influence of the protein in uninfected cells, a chain of mechanisms is launched that suppresses the synthesis of viral active substances;
• healthy cells produce a large amount of an enzyme that interacts with the virus, destroys its RNA, which leads to the death of the microbe;
• the drug activates hundreds of genes that provide powerful cell protection when faced with viruses;
• the protein limits the spread of pathogenic particles by activating the TP53 gene; it programs the death of the infected cell (apoptosis).

Interferon is a powerful stimulator of the child’s immune system. Coordinates the activity of leukocytes and lymphocytes, promotes increased production of macrophages (cells that capture and process foreign bodies) and natural killers (neutrophils).

The biological activity of the drug is very high. One molecule of the substance can create high resistance of a healthy cell against viruses.

Biological effects caused by the human protein Interferon:

• changes cell membranes;
• activates protective functions at the cellular level;
• suppresses viral replication;
• prevents the formation atypical cells and the development of neoplasms.

Release form of the drug and indications for use

Official name pharmacological drug– Human leukocyte interferon dry. It is obtained by synthesizing leukocytes from donor blood. The drug combines a group of proteins. However, it does not contain antibodies to viruses that cause diseases such as HIV, hepatitis B and C.

Interferon for children is no different from that for adults. The dosage of the active substance in the drug does not depend on the age of the patient.

The drug is available in the form of a powder for the preparation of drops. In color it is white or cream with a pink tint. It is a porous amorphous mass (no clear crystalline structure). The substance is hygroscopic, absorbs water and vapors from the atmosphere.

The dry lyophilisate is sold in transparent glass ampoules with a volume of 2 ml, which corresponds to the amount of the active substance (alpha interferon) of 1000 IU (international units). Medicines are not included antibacterial agents, preservatives, stabilizers and pharmaceutical excipients.

There are 10 pcs in one cardboard package. of the drug, the kit includes a knife or scarifier for opening ampoules, instructions for use. The drug is stored in the refrigerator at a temperature of 2 to 8°C. Shelf life from the date of production is 2 years.

A ready-made solution in bottles is also available. The medicine comes with two spray nozzles for nasal use.

Country of origin: Russia. average price for 10 ampoules - 100 rubles, the cost of one bottle with a ready-made solution is 120 rubles.

Interferon drops are indicated for the following viral diseases:

• respiratory infections (ARVI);
• flu;
• acute rhinitis;
• sinusitis of viral origin.

The drug is used during periods of increased epidemiological conditions for the prevention of colds in the autumn-winter period.

How to dilute Interferon and regimens for use in children

The ampoule with powder is opened immediately before using the medicine. To dilute the powder, you need sterile distilled water or boiled water cooled to room temperature. It is poured into the ampoule to the indicated mark. Shake the container gently until the contents are completely dissolved. The resulting solution should be transparent, colorless, with a light yellow or pink tint.. Slight opalescence of the liquid is acceptable (transparency indicator, the content of small particles visible in the light).

The resulting medicine is stored in the refrigerator for 24 hours.

Rules for using the spray nozzle:

1. A special nozzle for spraying the solution is used for a bottle or syringe with a collected solution.
2. The medicine is drawn from the ampoule into an injection syringe, and the needle is carefully removed.
3. Place the nozzle tightly onto the opening of the syringe.
4. The sprayer is brought tightly to the nasal passage, without gaps, so that the medicine does not get on the skin and eyes during irrigation.
5. With a sharp movement, push the syringe plunger and inject the solution into the nostril.
6. To carry out the procedure with the second nasal passage, draw the solution in the required amount from the ampoule. To do this, remove the nozzle and put on the needle.
7. Repeat the manipulation with the other nostril.

For children over 5 years old, the nozzle can be inserted into the nasal passages at a distance of 0.5 cm. In this case little patient should be in a vertical (sitting) position with your head slightly tilted back. After irrigation, you must remain in this position for a minute for maximum contact. medicinal solution with mucous membrane.

If the solution is prescribed to a child who cannot blow his nose on his own, then before administering the drug for a runny nose, it is necessary to thoroughly clean his nose of pathological exudate, mucus, crusts, and pus. For this, solutions based on sea salt are used - Salin, Humer, Aqualor, No-sol, Aqua Maris. If necessary, infants use a special aspirator to suck out mucus from the nose.

Treatment and prevention regimens for children

Interferon is prescribed as an intranasal solution for irrigation of the mucous membranes of the upper respiratory tract or instillation. For children over 3 years of age, the medicine can be used in the form of inhalations.

The drug is effective if used in the initial stages of a viral infection. The earlier Interferon drops are prescribed, the milder the disease progresses, the risk of complications is significantly reduced, and recovery occurs faster.

For the treatment of acute respiratory viral infections and influenza, the drug is administered into each nasal passage in a volume of 0.25 ml as a spray for irrigation of the epithelium. If the liquid is used as drops, then the child is given 5 drops into each nostril. The procedure interval is 1-2 hours, but not less than 5 injections of medication throughout the day. The therapeutic course for acute viral inflammatory process is 2-3 days.

Way inhalation administration medications are considered more effective. For one procedure, you need 3 ampoules of the drug, which are diluted in 10 ml of boiled water. It is better to use devices with a thermostatic function (heating and maintaining the temperature of the liquid). If the inhaler does not have such a function, then before use the solution is heated to t° 37C. The procedure is carried out 2 times a day, with an interval of at least 6 hours.

Inhalers are used to administer Interferon by inhalation. Nebulizers cannot be used, since the dispersion of the particles it produces does not meet the requirements for the use of Interferon. They are too small, which does not allow them to settle on the nasal mucosa and the medicine directly penetrates into the small bronchi and lungs.

For preventive measures Interferon is prescribed in the form of an aqueous solution as a nasal aerosol or drops. The dosage and regimen of use is the same as for the treatment of respiratory infections. The drug is used for prophylaxis only when potential threat infection of a child (through direct contact with a patient, tense epidemiological situation). The duration of taking Interferon into the nose for children lasts as long as the risk of infection of the body with viruses remains.

Features of the use of the drug in children of the first year of life

Since the drug is absolutely safe, it is prescribed from birth. The solution is used for infants only in the form of nasal drops.

Interferon for newborns is prescribed according to the same scheme as for children of other ages. The duration of therapy is no more than 3 days, prophylaxis is 7-10 days.

Algorithm for instilling a medicinal solution in children under one year of age:

1. Swaddle the child tightly so that he cannot actively move, lay him on his back, and turn his head to the side.
2. Using a pipette, drop the prepared solution (5 drops) into the nasal passage, which is located below, the medicine should irrigate the wall facing outward. This will prevent Interferon from entering the digestive tract.
3. Leave the child in this position for 3-5 minutes.
4. Repeat the procedure with the second nasal passage, turning the baby's head to the other side.

Contraindications and side effects

According to the official instructions for use, Interferon has no contraindications. It is not recommended to prescribe the drug to children with hypersensitivity to drugs containing protein.

Despite the fact that the drug is safe when applied topically, it is prescribed with caution to young patients with a history of allergies of various origins.

When used intranasally, the solution is not absorbed into the systemic bloodstream and does not have a toxic effect on the body.

It is strictly forbidden to prescribe medicine for parenteral administration - intramuscularly and intravenously. In this case, it causes severe side effects:

• mental disorders - depression, depression, suicidal tendencies in schoolchildren and adolescents;
• disruption of hematopoietic function;
• violations cardiovascular activity– arrhythmias;
• damage to the central nervous system - paralysis of the oculomotor nerves;
• loss of vision as a result of insufficient blood supply to the tissues and nerves of the eye;
• deterioration of the skin condition - rashes of various types, dryness and irritation of the epidermis, herpes, urticaria, furunculosis.

The drug cannot be used if the integrity and tightness of the packaging is broken (crack in the glass, partially damaged or broken capillary), there is no marking on both the cardboard box and the ampoule (bottle) itself, or the expiration date has expired.

Interferon nasal drops are an effective therapeutic and prophylactic agent that is successfully used in pediatric practice. The drug does not have a toxic effect on the children's body, has no contraindications, and is absolutely safe for children of all ages.

Thank you

Interferon is indicated for both prevention and treatment colds and flu. For prevention, it should be used during epidemics and discontinued as soon as the threat of the disease disappears. For treatment it is used from the beginning to the end of the disease.

For preventive purposes, interferon is sprayed or instilled, after diluting it with water. It is usually sold in ampoules. Pour water into the ampoule to the 2 ml mark and shake gently so that the drug particles dissolve in the water.

Place five drops of this solution in each nasal passage in the morning and evening. For treatment, the same solution is used, but with a different instillation interval. The same five drops must be dripped into each nasal passage every 2 hours, but at least five times a day. Such intensive interferon therapy is usually carried out over several days, two or three.

When spraying this drug Using any sprayer, 0.25 ml of solution is injected into each nasal passage. The sooner you start taking interferon for medicinal purposes, the faster it will help you. Doctors recommend inhalation with this drug for the flu. When inhaling through the nose or mouth, take three ampoules of the drug and dilute them in 10 ml of water. The water should be warm, but not hot: the optimal water temperature is 37 degrees. Inhalations should be done in the morning and evening.

This drug has no side effects or contraindications, so it can be prescribed even to infants. Ampoules with the drug should be stored under normal conditions.

Reviews

Actually, there are nasal forms of interferon, for example, influferon

Previously, interferon was dripped into my nose all my life and it helped a lot. And now I can’t find it anywhere, they say this drug is outdated, now, they say, people are already buying a barrier reef for prevention, which you just carry with you and you don’t get infected. But for me, let people at least buy something, why are old proven drugs taken off the market? All good things go somewhere.

I support Alex, the man digs deep and looks at the root: manufacturers are keeping back information that is inconvenient for them. Silence = lies, and this lie is in the name of profit. And in this whole business, citizens and your children are using you and your children as laboratory mice (based only on statistics).

I read and am amazed at the reviews. Dear. Ask your mothers yes Even little mothers treated them with this remedy. A little snot and immediately interferon in the nose. Yes, in theory, no medicine can be put into the nose of breastfed children. Violation in the body immediately. Either breast milk or interferon. Yes, even ask any nurse who has worked for a very long time. This is the best Remedy.

Why did you react so negatively to this article? There are many articles and columns on this topic, if a person reads this particular one, he will not immediately run to the pharmacy, but will read a dozen more of the same... and think about it! will think and decide what he needs! I think it’s a good and correct article...and I have nothing against human interferon, the drug has clearly passed all the tests! And you, in my opinion, Alex, are already starting to promote GRIPPFERON...look at another site!

In addition to Arbidol, I would also recommend taking Enterosgel, a couple of spoons at a time. In some ways it is even better than tablets - it does not irritate the mucous membrane and, in addition to the viruses themselves, it also absorbs all sorts of toxins from the stomach. And with swine flu there is always a stomach ache and diarrhea. So in this case, enterosgel is even better than other drugs. Some other sarbents are used, but I’ve already used them, I know. that the same polyphepam is generally impossible to drink, it’s like earth, so disgusting. And enterosgel is tasteless. You can even give it to children. So, don't get sick, get treated by the right means, verified.

You noticed absolutely correctly, dear Dmitry! Exactly geniuses!!! Who is stopping you from becoming one? Only you forgot one thing! From, as you put it, “chalk under the guise of pills,” many people recover! And marketing is all about convincing people like you that this is not just chalk, but medicine! Unfortunately, this does not always work out successfully, but still...

Disgusting propaganda site. The most disgusting thing is that it is very well made, decorated and promoted!
And also the comments are trolling!
In general, a typical American approach to promoting their products: “Marketing geniuses sell pieces of chalk under the guise of tablets...”

Manufacturers kept silent about contraindications and side effects, freaks in one word!

1) This interferon contains in 99.99% of cases active viral agents (for example, herpes viruses - almost all types) - they are taken from donor blood. For example, 90% of the adult population is infected with herpes simplex virus type 1. And there are dozens of similar viruses!

2) In addition to infection, this type of interferon also includes various peptide mediators that mediate immune reactions (inhibiting or enhancing) - mediators are also taken from donor blood.

Bottom line: if you want to catch HSV-1, HSV-2 or CMV infection ahead of time, then there is a tailwind!

P.s. If you really can’t stand it, buy RECOMBINANT drugs, not human ones. For example, the drug "Grippferon".

And I recovered surprisingly quickly, I don’t even want to buy anything else expensive imported drugs- they still don’t help. Although, by the way, it was dripping less than needed due to ignorance.

The article is detailed, but sometimes you don’t have time to see a doctor, and that’s when information from the Internet comes to the rescue.

Dear authors, are you sure that interferon has no contraindications or side effects? I just saw completely different information on another site with a whole list. Yes, and you can look it up in Mashkovsky’s reference book. Don't mislead people

Dear creators of this site! Remember that many people have the habit of trusting not professional doctors, but all sorts of other sources of information about health. No, you haven't written anything wrong. Everything is absolutely accurate. But it’s still better if in such articles it is mentioned as often as possible that it would be a good idea to consult a professional doctor before using this or that recipe.

Pathogenic microflora that develops in a person’s nose often becomes the cause of serious chronic diseases of the ENT organs. To combat microorganisms, various nasal drops are used - these are both immunostimulating and antiviral drugs, allowing for short time eliminate the threat. One of these remedies for children and adults is Interferon.

The spectrum of action of the drug is wide. It is used in the treatment of colds, laryngitis, pharyngitis, sore throat, and bronchitis. The product is based on substances that can activate protective functions in the human body to enhance the fight against pathogenic pathogens.

What is the drug Interferon

The manufacturers named the highly effective immunostimulant, which provokes the formation of recombinant interferon, almost identically - “Interferon”. The uniqueness of the properties of the drug lies in its positive effect on the body. The product relieves inflammation, kills germs and viruses, which allows for the most early stages development to overcome any infectious pathology.

Interferon does not contain antibiotics. The drug is made without the addition of dyes and preservatives, which increases its properties significantly, making the product accessible even to newborns.

In addition, Interferon does not cause allergies. The active substance of the drug helps reduce mucus secretion, destroys pathogenic microorganisms, relieves swelling and inflammation.

Release forms

Manufacturers have tried to diversify the release forms of Interferon, simplifying the use of the product for any infectious pathologies:

In the treatment and prevention of ENT diseases, drops are used for instillation into the nose, and ampoules are used for rinsing. Interferon is widely popular in powder form for nasal drops. The product in this form of release is often used for self-treatment runny nose

Indications for use

Among the infectious diseases developing in the ENT organs, the main ones for the treatment of which Interferon is prescribed are:

The medicine is instantly absorbed into the blood, improves the functioning of the immune system, and effectively fights microorganisms. Withdrawal occurs already on the second day after administration.

Interferon nasal drops: instructions for use

Depending on the patient’s age, an individual dosage and method of administration are selected. For newborns, only instillations are recommended; children over 3 years of age are allowed to rinse with the drug, as well as inhalations.

If the product is used as a prophylactic, it is permissible to instill up to 5 drops into each nostril no more than 2 times a day. During treatment, the dosage remains the same, but the frequency of procedures increases up to 6 times. The use of Interferon for more than eight days is not allowed due to rapid addiction.

How to drip for children with a runny nose

How to dilute Interferon for the nose: carefully open the ampoule with the drug, add boiled and cooled water to the container to the “2 ml” mark. Then shake the bottle slightly.

After dissolving the substance, a clear solution should be obtained. A yellowish tint is acceptable. An incorrect water concentration will be confirmed by a strange tint; it is better not to use such a preparation.

When directly instilling the product into the nose, the dosage of the drops is selected only by the attending physician.

For newborns, drops are not instilled into the nose, but tampons moistened with three drops of the drug are placed in the nasal passages. It is not recommended to keep tampons in a child’s nose for more than a quarter of an hour. The procedure is repeated 6 times a day at equal intervals.

Before performing any procedure, the child’s nasal passages must be cleaned by blowing his nose and removing mucus with a syringe. If possible, you can even rinse with water, special preparations made on the basis of sea salt and sea water.

How to drip with a runny nose for adults

Prevention of a runny nose in an adult begins with 5 drops of the drug twice a day, with an interval of about 6 hours. Treatment is performed with the same dosage, but the frequency of administration is increased at intervals of up to two hours. Three days are enough for the runny nose to go away.

When instilling the product, it is recommended that the patient tilt his head slightly upward. The substance is directed to the nasal mucosa. After administration, it is recommended to lightly massage the wings of the nose while inhaling through the nose. The diluted drug can be stored in the refrigerator for no more than a day.

Along with solutions, nasal spray has found widespread use for the prevention of influenza, runny nose, and colds. The substance is sprayed into the nasal cavity according to the instructions.

Contraindications

It is not advisable to drip interferon into the nose of children and adults if:

• cardiovascular pathologies;
• chronic hepatitis;
• disorders of the kidneys and liver;
• epilepsy.

Also, the drug should be discarded if its use causes:

Patient reviews

Natalya, 21 years old: “My daughter was barely a month old when we first encountered a runny nose. I was very worried, the doctor advised me to use Interferon. According to him, the product is absolutely harmless for small children and is most effective. Cotton flagella soaked in two drops of the drug were inserted into the nasal cavity three times a day. Already on the third day, the doctor canceled the treatment, as we felt better and had no more runny nose. The procedure is certainly unpleasant, since the daughter was capricious during cleansing her nose, but otherwise everything went well.”

Marina, 37 years old: “I have three children, one smaller than the other. Snot is a constant phenomenon that tormented us literally until last winter. The doctor advised me to use Interferon drops and spray and take an additional multivitamin complex. This winter passed almost unnoticed; our children did not suffer from colds. Even when the school was closed for quarantine due to outbreaks of influenza, the disease passed us by. It’s just that if there is any suspicion of a runny nose or cold, I immediately instill three drops in the children a couple of times a day for 2 – 3 days and that’s it. The drug did not cause any side effects for us.”

Conclusion

Considering the positive properties of Interferon nasal drops, it is not surprising that reviews from patients who have used them are most often positive. It is also worth saying that this remedy is indispensable in the prevention and fight against colds and chronic runny nose.

Understanding that the product has some side effects, it is necessary to consult a specialist before use, especially if treatment is necessary for an infant.

Directory of main ENT diseases and their treatment

All information on the site is for informational purposes only and does not claim to be absolutely accurate from a medical point of view. Treatment must be carried out by a qualified doctor. By self-medicating you can harm yourself!

Instructions for using interferon preparations for nasal instillation

The drops contain dried human interferon, which can have a local stimulating effect on human immunity. The medicine is prescribed as part of complex therapy as an aid in the fight against viral pathologies.

Action

According to the instructions for use of interferon, its use is relevant if a person suffers from any viral respiratory infection in acute form. What is the drug?

Interferons are special protein compounds that are actively synthesized by cells exposed to pathogenic viral particles. When additional proteins are in the body, they act as stimulants for a person's own immunity, activating its powers in the fight against infection.

Recent studies have proven that drugs with interferon are not only immunostimulants, but also immunomodulators. This means that they increase the body’s level of resistance to the negative effects of viruses, in some cases simply preventing a person from becoming infected, that is, acting as a preventive measure.

Preparations with interferon proteins are produced today in two ways: either through genetic engineering or through the use of human blood infected with a virus. Genetic engineering products are used in the creation of topical products such as nasal drops.

Indications

Today, drugs containing interferons are popular and often prescribed. In addition to nasal drops, suppositories, injection solutions, ointments, various tablets and other dosage forms are also produced.

Interferon nasal drops are prescribed mainly to combat acute respiratory viral infections and are effective in eliminating the symptoms of the pathology. The medicine is especially effective in the first days of the illness: the later it is prescribed, the more strong decline Doctors note its effectiveness.

Interferon preparations in the form of nasal drops are used in the treatment of young children. Pediatricians recommend that parents take a course of these medications if their child often suffers from upper respiratory tract diseases caused by viral particles.

The medication is also effective as a prophylactic agent during epidemic outbreaks of ARVI or influenza.

Contraindications

Today, many people believe that using interferon in the nose is one of the safest methods of treatment, but this is not entirely true. The drug, of course, according to recent studies, is completely safe, however, there are a number of contraindications that require mandatory consultation with a specialist before using it.

Instructions for use indicate the following contraindications:

• severe pathologies of the cardiovascular or nervous systems;
• negative changes in the functioning of the liver or kidneys, their severe diseases;
• acute form of allergy during the period of treatment;
• various thyroid diseases;
• the presence of individual intolerance to one or more components of the drug.

Interferon, even in the form of nasal drops, is recommended to be used with great caution in the first and second trimesters of pregnancy, when the vital systems of the fetus are actively developing. In this case, it is prescribed only on the recommendation of a doctor, when he is sure that possible consequences less dangerous for the fetus than the mother’s disease at the moment.

The drug is also not used in combination with vasoconstrictors, so as not to provoke severe drying of the nasal mucous membranes.

Names of nasal drops with interferon

Preparations with interferon for instillation into the nose are today available in three dosage forms.

The following medications can be found in powder form, from which the solution is prepared at home:

Many people find it more convenient to use already prepared medicine, and then drops sold under the following trade names are suitable:

Today, a product such as Ingaron is also produced in the form of drops. It contains not alpha, but gamma interferons, against which viral particles are not able to develop resistance. Thanks to this feature, Ingaron can be used regardless of the stage of the pathology.

When treating children under the first year of life, it is more convenient for many to use drugs in the form of a spray rather than drops.

In this case, the following medications are suitable:

All drugs, except powder ones, contain interferon obtained using genetic engineering techniques. The powder contains human protein obtained from blood.

Instructions

If a person decides to use not ready-made drugs, but powder to prepare medicine at home, then it will be necessary to dilute it before use. On all ampoules with powder there is a special mark indicating to what level the liquid must be added. It is best to use saline solution.

If everything is done correctly, you will get a reddish solution, which is used for instillation. The opened ampoule is kept in the refrigerator for no more than a day.

The medicine can be used for inhalation using special devices. To do this, you will need 3 ampoules of the drug iml warm water. Inhalations are done 2 times a day with an interval of at least 1.5-2 hours.

If the disease has already developed, treatment begins as early as possible. 4-5 drops are dripped into each nasal passage at intervals of every hour.

For prophylaxis, the same number of drops is used, but the frequency of administration of the drug into the nasal passages should be 2 times a day.

The dosage and frequency of use in the treatment of children and adults do not differ.

Adverse reactions

Interferon, although rare, does have side effects.

• various forms of allergic reactions - most often the skin version, i.e. the appearance of rash, itching, etc.;
• various pathological changes cardiac activity - pressure surges, arrhythmia;
• attacks of dizziness, headaches and muscle pain;
• dyspeptic type phenomena - nausea, loss of appetite, vomiting;
• convulsions;
• sleep disorders.

If interferon is used topically, the likelihood of developing such side effects is low. If a person nevertheless encounters negative reactions of the body, he is recommended to immediately consult a specialist.

Efficiency

Nasal drops with interferon contain a small concentration of the main active substance. Therefore, the drug itself does not demonstrate pronounced clinical effectiveness. It reduces the intensity of symptoms and shortens the duration of the disease, but is not able to provide complete recovery. Because of this, interferon is recommended to be used in parallel with other medications.

Doctors draw patients' attention to the fact that interferon drops do not act as a panacea. The drug is effective only as a preventive medicine or adjuvant.

Interferon is a good medicine that can increase the body's resistance to viral infections. The main thing is to use the medication in accordance with the instructions and only after its use is approved by the doctor. Before using the medication, you must ensure that there are no contraindications.

Interferon in ampoules: how to dilute, how and how much to drip for children

The onset of autumn cold eloquently indicates that the period of childhood colds is already on the threshold. Therefore, many parents are already trying to find for themselves all sorts of safe ways to treat and prevent viral diseases in their children. In this regard, interferon means are gaining more and more popularity every year. These medical supplies can not only help a child overcome dangerous infection, but also to increase the overall resistance of immunity to all kinds of dangerous environmental challenges.

That is why the drug “Interferon” has become widespread in general pediatric practice, which can be used both as drops and as an inhalation agent.

But, despite all its popularity and its rather long existence on the market, for many parents reliable information about interferons is a problem. Therefore, today we have to find out what this remedy is and how to properly drip Interferon to a child.

Composition and pharmacological actions

The general concept of Interferon hides one of the structural features of human immunity, namely a protein that is produced by the body in response to the damaging effects of bacteria. This structural unit interacts with the causative agent of the disease and ultimately blocks its reproduction.

Due to the fact that the child’s body is not capable of full functioning than an adult, interferon in the body of children is either not produced at all, or its quantity is insufficient for independent struggle with infection.

That is why in general medical practice, drugs based on this protein have become widespread in the treatment of children.

The main functions of interferons in the human body:

• stimulation of the production of substances that suppress the development of viruses;
• creating unsuitable conditions in cells for the proliferation of infectious agents;
• inhibition general processes life activity of the virus.

The drug "Interferon" is a powdery mixture of alpha interferons obtained from blood leukocytes. Moreover, they may include several types of protein compounds.

The powder is produced in the form of ampoules with a dry lyophilized mixture with an amount of interferons of at least 1000 IU. When prepared, the drug is a solution with a characteristic red tint.

The main effect of the drug introduced into the body is to slow down or completely block the ability of viruses to synthesize proteins important for their development. Active influence on the body of the drug manifests itself even in the case of complete cell damage.

In addition to the above, the active components help block the release of virion components, as well as the synthesis of its RNA.

The maximum concentration of the drug substance is observed in the blood within 3-12 hours after parenteral administration to the body, but after an hour, traces of the drug administration completely disappear. Moreover, its bioavailability is about 100%, regardless of the methods of administration.

What does it help with?

The main function of Interferon is its antiviral and immunomodulatory effects on the body during ARVI.

However, the remedy is quite effectively used in the treatment of:

• hepatitis B and C types;
• pointed kandiloma;
• myelomas;
• Kaposi's sarcoma in cases of AIDS;
• kidney carcinomas;
• leukemia;
• malignant melanoma.

Can it be used for babies?

Today, referring to general pediatric practice and instructions for use of the product, we can safely say that Interferon in ampoules is recommended for infants. However, there are some features that every parent should know.

In modern medicine, there are two forms of it: natural, made from human blood leukocytes, and artificial.

Unlike the natural form, the main advantage of the artificial form is complete safety and the absence of the possibility of infecting the child with any disease from the donor. However, despite this, to date WHO has not registered a single official case of human infection. infectious diseases by using natural forms of this drug.

Instillation into the nose: course and dosage

According to official instructions for the use of Interferon in ampoules for children, the use and preparation of this drug does not require special knowledge and skills. Therefore, many decide to make the product themselves.

However, in order for the entire process of treating the baby to be as successful as possible, you need to resort to some tricks of the procedure, which we will talk about later.

Dilution of the solution

To prepare an aqueous solution of the drug correctly, you first need to carefully open the glass ampoule. To do this, you need to cut the glass container along a special opening strip using a special disposable cutter (included with each box). After you have cut the ampoule, you need to break off the top cap of the container. However, it is not recommended to do this with bare hands, as otherwise you can cut yourself.

It is best to cover the cap with a handkerchief or a piece of ordinary fabric, after which you can break it more or less safely.

After you have managed to open the ampoule, you need to pour a small amount of clean distilled or boiled water into it up to the special mark on the ampoule. Next, the mixture must be thoroughly mixed; this can be done using a clean stick, syringe needle, etc.

You can also mix the solution by simply shaking it.

How to bury

After preparing the solution, it is important to find out how much children need to drip it to achieve the desired effect and how to do it correctly. Interferon using a special bottle with a spout; if it is not available, use a regular pipette.

Interferon needs to be used very often and a lot. At least 5 drops in each nasal passage, every 2 hours, but more often than 6 times a day. In case of a cold, the procedure must be carried out for at least 3 days.

For preventive purposes, the product is instilled 5 drops into each nostril, and the procedure should be carried out no more than 2 times a day with a break of at least 6 hours throughout the week. In the case of treatment or prevention of illness in an infant, special turundas moistened with 2-3 drops of the substance are used.

Solution for inhalation

With help active ingredients The drug can be used to make one of the best preparations for inhalation, which has the best stimulating properties for the overall immunity of the body.

Dilutions of the solution

The inhalation solution is prepared using a mixture of 3 bottles of dry substance and 5 ml of clean boiled or distilled water. The basic principles of the method described above for preparing a substance for instillation into the nose are ideal for this.

How to use

The procedure is carried out no more than 2 times a day. To do this, it is best to opt not for a steam inhaler, but for an ultrasound inhaler, since in this case the usefulness of the manipulation will be much higher. In addition, in this case, the baby will be almost 100% safe from possible burns from hot air streams. During the rapid course of the disease, inhalations should be carried out for at least 3 days, for preventive purposes - about 7-10 days.

Precautionary measures

The medicine is quite safe, but it should be used with extreme caution in children suffering from chronic allergic reactions. It should also be noted that if there is a medical history, the drug should be used exclusively under the strict supervision of medical specialists.

In addition, in the first stages of treatment, the patient must be subjected to hydration therapy, and when using sedatives, sleeping pills or an opioid analgesic, the baby's health must be carefully monitored.

Contraindications and side effects

Despite its effectiveness, safety and high effect, not everyone can use solutions of Interferon, since the substance can cause side effects.

The use of the product is strictly prohibited when:

• individual intolerance to components;
• impaired functioning of the kidneys and liver;
• neuralgic disorders, including epilepsy;
• diseases of the thyroid gland that are resistant to general therapeutic methods;
• severe heart defects and cardiovascular system;
• individual intolerance to chicken protein and antibiotic drugs in the anamnesis.

Period and storage conditions of the finished solution

In prepared form, Interferon is stored for no more than 3 days at a temperature of 2 to 8 ° C, after which it is necessary to prepare new batch substances.

In this article, we learned what Interferon is in ampoules and how to properly dilute the drug for children. The product provides powerful support to the human body in the fight against many infectious colds.

However, in order for the use of the medication to be truly effective and safe, it is necessary to strictly follow the conditions for preparing solutions of the drug according to the instructions.

We also bought a mobile phone, and the child found it interesting to play with it. We ordered online at the mamakupi.ua store.

Children should not take it without consulting a doctor. It could be worse. When my son had diarrhea, we were contacted by a pediatrician.

know the process according to natural ethics, and after a medical birth with friends and relatives, evaluate your dimensions.

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Girls, tell me how to breed interferon. In what proportions and how to drip.

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Interferon nasal drops: instructions for use. Reviews

Viruses lie in wait for humans everywhere at any time of the year, therefore, to prevent the development of acute respiratory viral infections or combat them, antiviral drugs and, in particular, Interferon nasal drops are often used.

But it is impossible to find a medicine in such a dosage form with exactly this name.

This is explained by the fact that, under the name Human Leukocyte Interferon, on pharmacy shelves there is a powder or lyophilisate for preparing a solution, packaged in ampoules.

It can be diluted and instilled into the nasal passages, or you can immediately purchase drugs in the form of interferon-based drops or spray.

What is Interferon: indications for use

Interferons are substances of protein origin produced by cells of the human body in response to the penetration of viruses.

They prevent the proliferation of viruses, their further spread and help activate the body’s synthesis of special cells that destroy viral particles.

There are several types of this substance, but alpha interferon is mainly synthesized by the pharmaceutical industry. It helps in every possible way to prevent viral diseases and speeds up recovery if infection does occur.

Therefore, medications based on it are widely prescribed for:

• ARVI;
• flu;
• rhinitis of viral origin;
• herpetic lesions of the mucous membranes or skin around the nostrils, etc.

They can also be used to prevent the occurrence of complications and the addition of a bacterial infection during prolonged or severe course ARVI.

But it should be noted that the use of drugs of this kind is practiced only in the vast expanses of post-Soviet countries, although their effectiveness has been confirmed by research.

What effect does the drug have?

It has a large list of pharmaceutical actions, including:

• anti-inflammatory;
• immunomodulatory;
• immunostimulating;
• antitumor;
• bacteriostatic.

But still his main thing positive property is a work antiviral effect. It is most advisable to use interferon in the nose for preventive purposes in the midst of epidemics or during initial stages development of the disease.

Today, the pharmaceutical market offers many interferon-based drugs in the following forms:

• powder for preparing a solution for local use (strictly prohibited for parenteral, that is, intravenous, intramuscular, etc., administration);
• nasal drops and spray;
• ointment;
• candles.

It is impossible to say unequivocally which form of release is better, since each of them has its own characteristics and advantages. However, powder and nasal drops or sprays are most often used for colds.

Contraindications and side effects

The medication is absolutely safe, since it is a natural compound for the human body, produced during various viral infections. Therefore, it can be used with virtually no restrictions, which is why it is sold over-the-counter from pharmacies.

But for a number of pathologies, its use is permitted only as prescribed by a doctor. This:

• severe diseases of the cardiovascular and nervous system;
• disorders of the liver and kidneys;
• acute allergies;
• pathologies of the thyroid gland;
• hypersensitivity to components.

Sometimes, while using the medication, patients experience an increase in body temperature and chills. But such a reaction of the body is normal, since this is how the fight against pathogenic microorganisms increases.

In rare cases, patients experience side effects such as:

• allergic reaction, in particular, the appearance of a skin rash, itching, etc.;
• short-term disturbances in the functioning of the heart, including arrhythmia and decreased blood pressure;
• dizziness, headaches and muscle pain;
• seizures;
• dyspepsia (nausea, vomiting, constipation, diarrhea);
• sleep disorders.

However, when used topically, the risk of side effects is extremely low, since the active substance is not absorbed into the blood.

More often, this is the result of an overdose, but in any case, if similar reactions are observed in response to its administration, you should consult a doctor as soon as possible.

Interferon: instructions for using nasal drops

Interferon powder for preparing nasal drops immediately before use must be dissolved with water for injection or regular boiled water (but not hot) to obtain 2 ml of solution.

For convenience and accuracy of dosing, each ampoule has a special mark up to which you need to add solvent.

The finished solution is transparent or has a slight yellowish tint. The dose and frequency of administration depends on the reason for its use and the age of the patient.

The method of using the finished preparations is described in the annotation for each of them, since each of them contains active ingredients in different concentrations.

When using it, you should not resort to vasoconstrictor drops to avoid drying out the mucous membrane.

Name of nasal drops with interferon

In the form of a powder for preparing a solution or a ready-made solution, you can purchase:

Medicines are also available in the form of drops and spray. Interferon drops are presented under the trade names:

1. Nazoferon (ME);
2. Grippferon (ME);
3. Laferon Nasal (ME).

There is a drug called Ingaron, but it contains not alpha, but gamma interferon, to which various viral particles are not able to develop resistance, making it effective at any stage of the disease.

But since the drug did not go away clinical researches on children, it is approved for use only for the treatment of children over 7 years of age and adults, with the exception of pregnant women.

For children over 1 year of age and adults, it is more convenient to use a nasal spray. In this form you can purchase:

• Nazoferon (ME);
• Genferon light (ME);
• Grippferon (ME).

All of the above drugs are obtained chemically, or rather biotechnologically, that is, they contain recombinant interferon.

Therefore, allergic reactions are more often observed when the latter is administered, since it is extremely difficult to completely purify the substance from foreign impurities, in particular proteins.

Interferon nasal drops for children: how to use

How to drip for children depends on the goals pursued, the age of the patient and the type of medicine chosen. A solution prepared at home from lyophilisate is used as follows:

1. For preventive purposes, Interferon is administered into the nose of children 5 drops twice a day with a break of at least 6 hours. The duration of therapy is determined by the severity of the epidemiological situation.
2. For treatment, children are administered 5 drops of solution every 2 hours for 3 days.

When choosing ready-made medications, you must be guided by the instructions for it and administer a strictly defined amount to the child in order to exclude the possibility of developing side effects.

After all, each drug contains a different amount of active substance, so ignoring the instructions can lead to the development of undesirable consequences.

For babies

Interferon-based products are also not contraindicated for babies of the first year. The solution prepared at home can be instilled directly into the nasal passages or used cotton swabs, moistened with 2-3 drops of medicine.

The use of sprays to treat children under 1 year of age is prohibited to avoid the development of complications. Drops are allowed to be used in strict accordance with the instructions for them.

Interferon during pregnancy

Interferon for the nose can be used without fear during pregnancy. Regardless of whether it is the 1st trimester or the 3rd, the dosage of the drug remains the same and corresponds to the administration of 5 drops every 2 hours for therapeutic purposes and twice a day for preventive purposes.

Storage conditions

Analogs

There are many antiviral agents. The following are available in nasal form:

The following are produced in the form of oral preparations:

Antiviral agents are also available in the form of ointments and suppositories:

Reviews

Price and release form

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Specialty: Otorhinolaryngologist Work experience: 12 years

Specialty: Otorhinolaryngologist Work experience: 8 years

The use of Interferon in the treatment and prevention of ARVI

Interferon, or more precisely, interferons, are proteins produced by the body (endogenous) that prevent viruses from entering cells. Interferon has immunostimulating activity, antitumor and antiproliferative effects.

In the form of a medicine, Interferon is effective in preventing infection with respiratory diseases and in the initial stage of development of colds. It is considered optimal against ARVI accompanied by rhinitis when it is recommended intranasally: as nasal drops, in the form of a spray or inhalation. Dispensed by prescription.

Mechanism of antiviral action and other features

In the treatment of ARVI, a subtype of Interferon is used - human leukocyte alpha-interferon and its recombinant analogues. The drug increases the resistance of uninfected cells to virus penetration. Interferon binds to receptors on the cell wall membrane, changing its properties so as to reduce the adhesion of the virus, it also acts on the RNA of the viral cell, stopping the reproduction of the virus genotype, and stimulates the production of certain enzymes for the immune response.

Dosage forms

Interferon is produced in a wide variety of therapeutic forms, depending on the goals of treatment.

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For the treatment and prevention of colds, three forms are usually used:

1. Ready-made nasal drops
2. Nasal spray
3. Powder for preparing nasal drops

Indications:

• The initial stages of the development of influenza infection: runny nose, sneezing, nasal congestion, cough, deterioration in general condition.
• Parainfluenza, adenovirus, rhinovirus and rhinosyncytial infections.

Contraindications.

Most of the contraindications relate to the use leukocyte interferon, some of its recombinant analogues can be used for compelling indications, exclusively for medical purposes.

Interferon is not used to treat patients with organic heart pathologies or advanced renal impairment; also, it cannot be prescribed for chronic hepatitis and cirrhosis in the stage of decompensation, for autoimmune hepatitis; Interferon should not be used for thyroid pathologies that are resistant to conservative therapy; with impaired central nervous system functions, in people with epilepsy and increased susceptibility to alpha interferon.

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The use of Interferon is prohibited in pregnant women and lactation period, except when the benefit of treatment to the mother takes precedence over the risk to the child. If taking the drug during lactation is unavoidable, it is recommended to avoid breastfeeding.

Some analogues containing other subtypes can be prescribed to pregnant women, but only in consultation with a doctor.

How is it used in childhood?

Pediatricians consider Interferon one of the drugs of choice for the prevention and treatment of ARVI in children.

Interferon can be used in children at almost all stages of the disease, but it is most effective when initial symptoms colds: sneezing, coughing, runny nose. For children, nasal drops, spray and inhalations are used.

In premature infants who often fall ill, and children with congenital pathologies An analogue of Viferon is used.

Treatment of children with Interferon for too long is inappropriate due to the development of addiction and a decrease in the expected effect.

How to use?

For ARVI, Interferon is used either as drops and nasal spray, or in the form of a lyophilized powder produced in glass ampoules. The powder for preparing the dosage form must be diluted by injecting saline or boiled water– up to the mark on the wall of the ampoule. The finished solution is red in color and can be used in the form of nasal drops, which should not be stored for more than a day; then a new ampoule with powder is needed to prepare the drug.

To prevent infection, drops of 0.25 ml - 5 drops are applied into each nostril. The interval between administrations is 6 hours. It is necessary to drip while there is a threat of infection - during the cold season, if there are people sick in kindergarten, at work, in the family.

To treat colds, Interferon drops need to be dripped 0.25 ml - 5 drops into the nostril, the frequency of administration is at least 5-6 times a day, the interval between procedures is 1-2 hours. Duration of therapy is 3-5 days.

Interferon in the form of ready-made drops has a nozzle and dispenser that makes it easier to administer the solution into the nose, especially in children.

The child should be given nasal drops according to the following algorithm:

1. Turn the open bottle vertically, with the nozzle down, and testly press the dispenser several times.
2. Place the tip of the nozzle into your nose and press the dispenser the required number of times.
3. After finishing the procedure, screw the cap on the bottle.

Interferon in the form of a nasal spray is often prescribed to children over the age of one year. It is recommended to administer 2 doses of spray 3-4 times per day, the volume is similar to 2 drops of the drug. For children aged 3-14 years, the spray is injected 2 doses 4-5 times a day, for adult patients - 5-6 times a day 3 doses.

Side effects

It can cause quite serious side effects on many organs and systems. As a rule, all adverse reactions occur when it is used parenterally, intravenously or intramuscularly, but it is always worth keeping in mind that other forms of release can also provoke the appearance of adverse effects.

The most common reactions are:

Gastrointestinal tract: loss of appetite, vomiting, diarrhea, occasionally problems with the liver;

Rare side effects include secondary viral infection, such as the herpes virus; visual impairment, hearing impairment; conjunctivitis; weight loss.

Other characteristics of the drug and analogues

Compatibility and interaction with drugs.

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Interferon and its analogues slow down metabolic processes in the liver, so its parallel use with drugs that transform in the liver can disrupt this process.

Reception with ACE inhibitors may lead to synergism in hematotoxic effects; Interferon and Zidovudine, when used together, can cause synergism in the myelotoxic effect, as well as when combined with a cytostatic group of drugs; with Paracetamol, Interferon stimulates the activity of liver enzymes, and with Theophylline, it reduces its clearance.

Caution should be prescribed in parallel with hypnotics and sedatives, antidepressants, as well as a group of opioid analgesics.

Price.

As a rule, it depends on the manufacturer’s policy, the volume of ampoules, the release form, the pharmacy chain and the region of sale. The price may therefore vary. Interferon in the form of lyophilized powder for the preparation of nasal drops costs from 80 to 120 rubles per package.

Storage conditions.

Stored at a temperature of +2-+8oC, in a dark place. Shelf life: 2 years.

Analogues.

Each subtype has its own analogues.

The alpha-2a subtype includes Roferon and Reaferon, the alpha-2b subtype includes Viferon, Intrek and Intron-A; alpha-2c has analogues: Egiferon, Velferon and Berofor.

Beta interferons include Betaseron, Fron, and gamma interferons include Immunoferon, Gammaferon and Imucan.

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– provide current and useful information about the diseases treated by an ENT doctor (otolaryngologist). The pages of our website contain information about the main symptoms of diseases of the ENT organs, as well as methods of their treatment - both in medical institutions and at home. It should be noted that the authors of the project work on the articles with a medical education (you can see information about the editorial team on the “About the site” page), so the main task of the portal is to provide reliable information that will allow you to promptly detect the problem and seek qualified help in a timely manner.

It is quite difficult to protect your child from colds. When children begin to get sick, parents try to use only the safest and most effective medications. Interferon belongs to this group of drugs. It has unique properties, so it is often used in pediatrics. What kind of product is Interferon nasal drops and how to use it correctly without harm to health in the treatment of children?

Interferon and its properties

Interferon is a substance synthesized by almost all cells of the human body. Scientists have managed to create such a unique substance artificially. Developed medicine has several important properties:

• immunostimulating;
• anti-inflammatory;
• antimicrobial;
• antiviral.

This medication helps increase the body's protective properties. The substance interferon does not act directly on the virus. It leads to the suppression of the proliferation of infections and provides protection when they attack the body. Area of ​​application of the medicine very wide:

• gynecology;
• ophthalmology;
• gastroenterology;
• pediatrics.

Very often, pediatricians prescribe Interferon nasal drops to treat runny nose in children. The drug is considered safe for child's body, so it can be used by children from a very early age. After using the medication, the body's cells briefly produce their own interferon, which is able to fight viruses.

Purpose

Interferon is a very popular drug today. It is available in several dosage forms:

• nasal drops;
• candles;
• pills;
• solutions for injections;
• ointment;
• dry powder.

This medicine is good protective agent for the prevention and treatment of many diseases:

• viral diseases affecting the respiratory system and internal organs;
• inflammatory diseases of the mucous membrane;
• oncological diseases;
• multiple sclerosis, herpes zoster;
• eye diseases.

For acute forms of viral respiratory infections and to eliminate signs of a cold, nasal drops are prescribed. Pediatricians often recommend that parents of young children use nasal drops if the child often has pharyngitis, laryngitis and other respiratory diseases upper section and mucous membranes of an infectious nature. The drug is recommended for use for prevention purposes and during epidemics of influenza and ARVI in kindergartens and schools, as well as in clinics.

Interferon nasal drops: instructions for use

If you have influenza or acute respiratory viral infection, it is recommended to use the drug as early as possible with the appearance of the first signs of the disease. To use the medicine, it must be diluted with cool boiled water. On the ampoules of the medicine there is a 2 ml mark; according to the instructions, you need to add water to this mark. The finished drops should have a transparent or slightly yellowish tint. If the resulting liquid is not prepared correctly, then its color will vary.

For prevention purposes, it is recommended for adults to drip 5 drops 2 times a day with at intervals of at least 6 hours. At the first symptoms of the disease, it is necessary to drip 5 drops at intervals of 2 hours for 3 days. After introducing drops into the nose, you should lightly massage the wings of the nose so that the solution is better and evenly distributed. Intensive therapy significantly alleviates the patient's condition. According to the instructions, it is recommended to store the finished product in the cold for no more than 1 day. Do not use the medicine together with vasoconstrictor medications for the nose. This treatment will lead to dry nasal mucosa.

Drops are used only for administration into the nose. The remedy begins to act immediately, but a positive result in the treatment of children can be seen in just a couple of days. It is recommended to use Interferon for the treatment of infants and newborns recombinant group, not natural.

Interferon is most convenient to use for newborns by alternate introduction, soaked in turunda solution. 2-3 drops of the medicine are dripped onto them and placed in the nasal passage. The flagella in the nose should be left for 10-15 minutes, repeating the procedure 4-6 times a day. You can also put drops into your nose, but the pediatrician must tell you in what quantity and how many times a day.

Interferon is also used for infants in another dosage form in the form of suppositories. They are used in a course of 5 days, which significantly improves the baby’s health. If the disease does not subside after a few days, it can be repeated again.

Contraindications and side effects

Despite high efficiency in the treatment of many diseases. This product has there are contraindications. It should not be taken by people who suffer from certain diseases:

• allergy;
• heart diseases;
• nervous system;
• pathology of the liver and kidneys;
• thyroid disease;
• intolerance to individual components.

Adults and children may experience symptoms after using this medication. side effects in the form of:

• nausea and headache;
• insomnia;
• increased body temperature;
• vision problems;
• pulmonary edema.

Interferon should be taken with caution by pregnant women. It cannot be used long time adults and children, as there is a risk of decreased immunity. It is especially important to take this into account when treating children, because they the immune system not yet fully formed.

Efficiency

Nasal solutions contain low concentration main substance. It does not give a pronounced clinical effect. It can reduce the occurrence painful symptoms and the number of days of illness, but will not give full recovery. Interferon is recommended to be used in combination with other drugs to treat diseases.

This drug is not a panacea, it serves as an auxiliary medication during therapy. Interferon is good medicine, capable of protecting the body from ARVI viruses, but it should always be taken as prescribed by a doctor, according to the instructions and in the absence of contraindications.