Coldact side effects. Release forms and prices for the drug are average in Russia. Side effects of Coldact flu plus

While not particularly dangerous to human health in general, the common cold is extremely unpleasant illness. Elevated temperature headache, sore throat, runny nose - who is unfamiliar with this condition? But many people have to work while, for a number of reasons, not being able to take sick leave. In this case, taking Coldact Flu Plus can help.

Release form, packaging, composition

This product is a capsule with a prolonged action. Each of them contains 25 mg of phenylephrine hydrochloride, 200 mg of paracetamol, 8 mg of chlorphenamine (chlorpheniramine) maleate. The drug is packaged in cardboard packs, each of which contains a blister with 10 capsules.

The medicine is also offered in the form of a suspension for internal use. It contains 2 mg of chlorphenamine maleate, 125 mg of paracetamol, 5 mg of phenylephrine hydrochloride. It is sold in bottles (60 ml). Each of them comes with a dosing spoon.

A good antipyretic drug is the drug.

What it is

Coldact Flu Plus is intended for the treatment of acute symptoms respiratory diseases . As can be seen from its composition (given above), the drug is not an antibiotic, since its components do not affect the virus. This medicine has a combined effect:

• Antiallergic. It is provided by the presence of chlorphenamine, which eliminates itching in the nose and eyes, as well as lacrimation.
• Antipyretic and analgesic. It is explained by the presence of paracetamol in the medicine, which reduces the pain syndrome that often occurs with a cold (pain in the joints and muscles, throat and head), and also reduces high fever.
• Vasoconstrictor. Phenylephrine is responsible for this effect, reducing inflammation of the mucous membranes of the paranasal sinuses and upper respiratory tract, as well as their swelling.

Indications and contraindications

Purpose this drug– relieve symptoms of influenza, ARVI, colds, such as pain, rhinorrhea, fever.

IN following cases Coldact Flu Plus cannot be used:

• with hypersensitivity to any of its components;
• at diabetes mellitus;
• with difficulty urinating (in patients with prostate adenoma);
• at serious illnesses kidneys and liver, heart and Bladder;
• with severe atherosclerosis coronary arteries;
• with thyrotoxicosis;
• at arterial hypertension;
• for gastric ulcers and duodenum;
• for diseases of the blood system;
• for diseases of the pancreas;
• with deficiency of glucose-6-phosphate dehydrogenase.
• with angle-closure glaucoma;

People suffering from congenital hyperbilirubinemia (Rotor, Dubin-Johnson and Gilbert syndromes), as well as chronic obstructive pulmonary disease and bronchial asthma, should use caution when taking this medicine.

Patients suffering from severe renal or liver failure, pregnant and lactating women, as well as children under 12 years of age should not take the drug.

Dosage and overdose

Coldact Flu Plus is used internally twice a day and has the following dosage: children over 12 years of age and adults drink a teaspoon of suspension or 1 capsule per dose. As an antipyretic, you can take the medicine for no more than 3 days, as an analgesic - no more than 5 days.

Capsules should not be chewed with sufficient water.

Treatment should be symptomatic, since it does not have a specific antidote.

In case of an overdose, symptoms may occur caused by excess paracetamol in the body:

• pallor;
• increase in prothrombin time;
• nausea;
• hepatonecrosis;
• vomit;
• increased activity of liver transaminases.

For treatment, gastric lavage and the introduction of SH-group donors into the patient’s body are indicated within the first 6 hours, after 8-9 hours - precursors for the synthesis of glutathione-methionine, after 12 hours - N-acetylcysteine.

If an overdose of the drug accidentally occurs, you should immediately consult a doctor, regardless of the manifestation of any symptoms.

Interaction with other drugs

When taking Coldact Flu Plus with hypnotics and psychotropic drugs, an increase in their sedative effect may be observed.

If the drug is used in parallel with rauwolfia alkaloids, tricyclic antidepressants, MAO inhibitors, adrenoreceptor blockers, methyldopa, ganglion blockers, in some cases blood pressure increases.

This drug increases the possibility of developing the hematotoxic effect of paracetamol if it is taken simultaneously with carbamazepine, rifampicin barbiturates, diphenin, zidovudine, as well as other inducers of microsomal liver enzymes.

At joint reception can happen with furazolidone hypertensive crisis, an excited state or hyperrexia may occur.

Paracetamol, which is part of the drug, leads to a decrease in the effect of uricosuric drugs.

If Coldact Flu Plus is used together with antidepressants, antiparkinsonian and antipsychotic drugs, phenothiazine derivatives, urinary retention, constipation, and dry mouth may develop.

Coldact Flu Plus should not be taken simultaneously with medications containing paracetamol, or with alcohol.

Shelf life, storage conditions

Coldact Flu Plus should be stored in a dark place, the temperature should not exceed 25 °C. The drug is valid for two years.

In the treatment of acute respiratory diseases, against fever and inflammatory process Pentaflucin has proven itself well, which is what they are talking about.

Side effects

Usually the medicine is well tolerated by patients. IN in rare cases The following side effects have been observed:

• decreased appetite;
• tachycardia;
• gastrointestinal disorders;
• drowsiness;
• dizziness;
• dry mouth;
• promotion intraocular pressure;
• anemia, leukemia, agranulocytosis, thrombocytopenia (rare);
• allergies (very rare).

If the medicine is taken in high doses, it can have nephrotic and hepatotoxic effects on the patient's body.

It is also prescribed to elderly patients.

Drivers should be careful when taking this drug.

It is probably pointless to talk about the unpleasant symptoms of acute respiratory infections and acute respiratory viral infections. Tearfulness, runny nose, sore throat, swelling of the mucous membranes and, of course, fever not only take a lot of energy, but also cause significant discomfort. You can cope with such manifestations of these common diseases with the help of drugs related to pharmacological group combined analytes, such as Coldact Flu Plus. By starting treatment at the first symptoms, you can avoid not only the manifestations of subsequent reactions, but also reduce the severity of the disease.

Composition and pharmacodynamics of the drug

The product consists of three main components that have the same effect on the body. The first of these is chlorphenamine, which has an antiallergic effect. Thanks to this substance, watery eyes and itching in the nose and eyes are eliminated. The second component is paracetamol, which has an analgesic and antipyretic effect. It is what reduces pain during colds: headache, joint and muscle pain, and also effectively performs an antipyretic function. The third component of the drug "Coldact Plus" is vasoconstrictor phenylephrine. It reduces hyperemia, swelling paranasal sinuses eyes and mucous areas of the respiratory tract. Hypromellose, talc, diethyl phthalate, ethylcellulose, povidone, MCC, isopropanol, purified water, disodium edetane, sodium disulfite, zakotko yellow and quinoline yellow dyes are used as auxiliary components in the product.

Indications for use

Thanks to his complex action on the body, the drug is used as a symptomatic treatment of colds and respiratory tract infections of various origins. Eliminates fever and pain, as well as rhinorrhea. And despite the fact that the medicine is available at the pharmacy without a prescription, treatment should be started only on the recommendation of a doctor.

For whom the drug is contraindicated

This medicine It has larger list contraindications compared to medications with one active ingredient. And the first position in this long list is occupied by increased sensitivity to components. The use of the drug is not recommended for people suffering from severe atherosclerosis of the coronary arteries and arterial hypertension, since phenylephrine is contraindicated for them. You should also stop taking this medication if you have angle-closure glaucoma, diabetes mellitus, as well as peptic ulcers of the stomach and duodenum. The effect of the drug may also have a negative effect in patients with diseases of the pancreas, liver, heart and renal failure. The use of Coldact Flu Plus is strictly not recommended for prostate adenoma, thyrotoxicosis and diseases of the blood system. A separate position in the list of contraindications is occupied by pregnancy, the lactation period necessary for children and the age criterion: for suspension - up to 6 years, for capsules - up to 12 years. The use of the medicine is allowed, but with extreme caution and under medical supervision for congenital hyperbilirubinemia (Dubin-Johnson, Gilbert and Rotor syndromes), as well as COPD and bronchial asthma.

Adverse reactions of the body

According to the results of the studies, when taking the medicine, body reactions such as tachycardia, increased blood pressure and intraocular pressure, accommodation paresis, mydriasis, dizziness, drowsiness and, at the same time, difficulty falling asleep are noted. Quite often, patients complain of increased excitability, discomfort due to dry oral mucous membranes, significant loss of appetite and nausea. As a rule, these phenomena disappear immediately after the end of treatment without additional drug therapy. Much less frequently, when taking the drug Coldact Flu, patients may experience anemia, agranulocytosis, leukopenia, thrombocytopenia, and with a long course of treatment, even nephrotoxic and hepatotoxic effects. In isolated cases, an adverse reaction may be urinary retention and allergies, manifested in the form of itching, urticaria and skin rash.

Interaction of the drug with other drugs

At simultaneous administration this tool with barbiturates, carbamazepine, diphenin, rifampicin, zidovudine and other inducers of microsomal liver enzymes due to paracetamol, the risk of hepatotoxicity increases. At complex therapy with ethanol and monoamine oxidase inhibitors increases sedative effect. Only as prescribed by a doctor can you take the drug with antidepressants, phenothiazine derivatives, antipsychotic and antiparkinsonian medications, as the risk of urination problems, as well as constipation and dry mucous membranes increases.

It is worth paying attention during therapy to the fact that paracetamol, which is part of the medicine, significantly reduces healing effect uricosuric medications. The drug should not be combined with furazolidol, since such a combination can cause hyperexia, agitation, and even hypertensive crisis. The simultaneous administration of tetracyclic antidepressants enhances the adrenomimetic effect of phenylephrine, and combination with halothane can cause ventricular arrhythmia.

Directions for use and dosage

Each of the two forms of the drug “Coldact Flu Plus” - suspension and capsules - has an identical effect on the human body. In liquid form, the drug is prescribed to both children 6-12 years old, as well as older children and adults. Moreover daily dose for babies it should not exceed 20 ml, divided into 3-4 equal doses, and for adults it is taken according to the same schedule, only in double the amount. As for capsules, they can be used for treatment only from 12 years of age, taking only 1 capsule twice a day. The course of treatment, or rather its duration, does not depend on the form of the medicine and is calculated individually for each individual patient by the doctor. As a rule, the duration of use as an antipyretic drug cannot be more than 3 days, and for the purpose of pain relief - 5 days.

Measures in case of overdose

In some cases, the dose is exceeded medicinal product already after a short period of time sufficient serious violations health. This may include a noticeable decrease in appetite, unnatural pallor skin, increased PV, nausea, vomiting, and hepatonecrosis. All these symptoms are a consequence of the action of increased doses of paracetamol and require urgent inpatient treatment. In the first 6 hours medical institution The patient is given gastric lavage, then SH-group donors and methionine synthesis precursors are administered in an individual dosage over a period of 7-9 hours. The final treatment for overdose is the administration of N-acetylcysteine.

special instructions

At first sight, famous drug"Coldact Flu Plus" for many is simply a panacea for respiratory and viral infections respiratory tract, but we must not forget that this medication, if the basic requirements for administration are violated, can significantly aggravate the patient’s condition. Therefore, when deciding on such treatment, you should consult a therapist and read the instructions in great detail. You should definitely pay attention to the list of contraindications, and if any of them are present, refuse such therapy. During the entire course of taking the drug, you should not take alcohol or other medications containing paracetamol. It is also necessary to abstain from tranquilizers, sedatives and psychotropic drugs, since manifestations of negative adverse reactions body. During this period, if possible, you should avoid driving vehicles and other dangerous activities that require quick psychomotor reactions and special concentration.

– 0.5 g + Chlorpheniramine maleate – 0.08 g and additional substances that make up the gelatin shell.

Included Coldact Flu Plus active ingredient capsules: paracetamol – 0.2 g; – 8 mg; – 25 mg and Excipients (hypromellose, MCC, talc, ethylcellulose, povidone, diethyl phthalate, dyes, sucrose, water, sodium disulfite, starch syrup, disodium edetate, granulated sugar).

Suspension Flu Plus contains active ingredients: chlorphenamine maleate – 2 mg; paracetamol – 0.125 g; phenylephrine hydrochloride – 5 mg + carmellose sodium, propyl parahydroxybenzoate, disodium edetate, methyl parahydroxybenzoate, sodium saccharinate, sodium chloride, MCC, glycerin, sucrose, xanth gum, silicon dioxide, flavorings, polysorbate 20, sodium citrate, water, citric acid.

Release form

Coldact released in capsules long-acting in a gelatin shell, packs of 10 pieces.

Coldact Flu Plus- in two forms:

• shelled capsules made of gelatin, half red, half transparent, inside - yellow, red and white pellets, in packs of 10-100 pieces;
• suspension for internal use, viscous, orange, with a specific odor, in a bottle of 60 ml.

pharmachologic effect

Antihistamine action , constricts blood vessels. Anticongestive .

Flu Plus also has antipyretic And painkillers action.

Pharmacodynamics and pharmacokinetics

Included in the tablet Coldact And Koldakt Plus chlorpheniramine is the most effective antihistamine , reducing the impact on H1 receptors . Also has minor sedative And antimuscarinic Effect. The substance has the ability to reduce the permeability of mucosal cells in the nose, thereby reducing unpleasant symptoms(itching and swelling).

The process of interaction with blood plasma occurs slowly. The maximum concentration is after 2-6 hours, metabolized in the body. However, a small part of it is excreted by the kidneys.

Other active ingredient - phenylpropanolamine is symptomatomimetic . Affects alpha adrenergic receptors , but to a lesser extent than, for example, . Possesses vasoconstrictor, anti-edematous effect on the mucous membrane of the nose and paranasal sinuses.

Reaches maximum concentration within 2 hours. Excretion is carried out through the kidneys.

Reduces body temperature and relieves pain. Helps eliminate cold symptoms - headaches, joint and muscle pain, unpleasant sensations in the throat.

It binds poorly to blood proteins, less than 10%, is metabolized in the liver, maximum concentration is after 3 hours. Excretion occurs in the urine within 24 hours after administration.

Indications for use

• (vasomotor or allergic );
• relief of cold symptoms such as allergization, swelling, runny nose, stuffy nose .

Contraindications

The suspension can be taken by children from 6 years of age.

Flu Plus has a number of additional contraindications:

• severe forms of kidney, liver, heart, gall bladder diseases;

Side effects

Doesn't happen often:

• drowsiness, headache, overexcitation and excessive irritability;
• hepa- And nephrotoxic impact;
• dryness in oral cavity, diarrhea, nausea, loss of appetite ;
• increase, vision problems;
• chest pain, dysuria ;
• pain in epigastric region , loss of appetite.

Instructions for Koldakt (Method and dosage)

The duration of administration and dosage should be prescribed by a doctor.

According to the instructions for use of Koldakt, adults are prescribed 2 capsules per day, divided into 2 doses.

The course of treatment is from 1-3 ( , ) up to 30 days.

Instructions for use Coldact Flu Plus

According to the instructions for Coldact Flu Plus, two capsules are prescribed per day, at regular intervals.

The syrup should be shaken well before use.

Adults are prescribed 30-40 ml per day, in 3-4 doses. Children from six years old – 15-20 ml, in 3-4 doses.

The course of treatment, as a rule, is no more than five days.

Overdose

No cases have been reported. Therapy - according to symptoms.

For the form that includes paracetamol, the symptoms are: nausea, hepatonecrosis , pallor and weakness, loss of appetite. See a doctor as soon as possible and rinse the stomach, administer SH-group donors , methionine (first 8 hours) or N- (12 hours).

Interaction

Use with caution in combination with MAO inhibitors, tricyclic antidepressants, halothane, guanethidine,

Coldact instructions

Koldakt is antiallergic combined agent. The drug, due to its components, has vasoconstrictor properties, helps normalize the mucous membranes of the respiratory tract and improves their patency. The main component of the drug - phenylpropanolamine - is a symptomatic with vasoconstrictor and anorexigenic activity. Thanks to the second component, chlorphenamine, which is an antihistamine drug, all symptoms of rhinitis are suppressed allergic form- sneezing and rhinorrhea, itching in the eyes, nose and throat.

Coldact composition

The drug is available in the form of syrup, tablets and capsules.

The syrup of this drug contains substances such as chlorpheniramine maleate BP, phenirpropanolamine hydrochloride BP, and a flavored base for the syrup. Tablets and capsules contain chlorpheniramine maleate BP, phenylpropanolamine hydrochloride BP.

Coldact application

The medicine Koldakt is used in case of colds, rhinitis and rhinorrhea, sinusitis, nasopharyngitis and allergic rhinitis.

Coldact dosage

The medicine is intended for oral administration. Adults are prescribed to take 1 capsule about two times a day. Capsules should be swallowed whole without chewing and washed down big amount water. Treatments for influenza and ARVI last approximately three days. When acute sinusitis Prescribe 1 capsule about twice a day. Duration of treatment for sinusitis acute form is approximately 12 days, sinusitis chronic form– about 30 days. When treating rhinorrhea, 1 capsule is prescribed once a day. The duration of treatment is about 7 days.

IN childhood Children aged 5-6 years are prescribed about 5 ml of syrup. every 4 or 6 hours; children aged 6-12 years are prescribed syrup in a dose of 5 ml every 4 hours. The duration of treatment for children is about 5 days.

Coldact flu plus

The drug is available in the form of capsules that have a prolonged effect. They contain phenylephrine hydrochloride, chlorphenamine maleate and paracetamol. With the use of capsules that have an antiallergic effect, they eliminate lacrimation and itching in the eyes and nose. Thanks to paracetamol, which has analgesic and antipyretic properties, it reduces pain symptoms that appear during colds such as sore throat, headache, muscle and joint pain, lowers the temperature. Unlike paracetamol, phenylephrine has vasoconstrictor properties, which reduce swelling and hyperemia of the mucous membranes of the respiratory tract and in the paranasal sinuses.

Use Coldact Flu Plus in symptomatic treatment colds, in the treatment of influenza, ARVI.

For the treatment of adults and children over 12 years of age, the medicine is prescribed in next dose: 1 capsule every 12 hours. The duration of treatment is about 5 days. The drug is used as an antipyretic for no more than 3 days, and as an analgesic for no more than 5 days.

Coldact Broncho

The drug is produced in the form of syrup, which is a combination product. Thanks to its constituent Guaifenesin and Ambroxol, which are mucolytic substances, it can reduce the viscosity of bronchial secretions and facilitate expectoration of sputum. In addition, chlorphenamine, which is part of it, has antihistamine effect and is able to eliminate itching of the mucous membranes of the nose and eyes, eliminate bleeding, and phenylephrine, an alpha1-adrenergic stimulant, has vasoconstrictor properties and is able to reduce swelling and hyperemia of the mucous membranes of the respiratory tract and paranasal sinuses.

The medicine is used for the symptomatic treatment of colds, influenza, acute respiratory viral infections, which are accompanied by severe cough and sputum with a viscous consistency that is difficult to separate.

For the treatment of adults and children over the age of 12 years, 20 ml of syrup is prescribed about three times a day. Children aged 6-12 years are prescribed 10 ml of syrup about three times a day. The duration of treatment is usually 7 days.

Coldact Lorpis

The drug is antiseptic and is available in the form of tablets with different flavors. This medicine has anti-inflammatory, analgesic and local anesthetic effects. The components included in its composition are capable of coagulating proteins in microbial cells and are active against gram-positive and gram-negative microorganisms, and thanks to them the medicine has antifungal properties. With its use, symptoms manifested by irritation of the mucous membranes of the respiratory tract are eliminated, since medicine has a decongestive effect on mucous membranes. Using it in treatment, nasal congestion decreases and irritation and sore throat are not so severe.

Apply this type drug in case of infectious - inflammatory diseases mouth, throat, larynx, that is, with tonsillitis, pharyngitis, laryngitis. The medication is effective for hoarseness, inflammation of the mucous membranes in the oral cavity, gums, that is, for aphthous stomatitis, gingivitis and thrush.

For the treatment of adults and children, 1 tablet is prescribed every 3 hours; the tablets are not swallowed, but kept in the mouth until completely dissolved. You can take no more than 8 tablets per day.

Coldact during pregnancy

The drug should not be used to treat pregnant women or during lactation.

Koldakt analogues

Analogues of a drug are drugs that are similar in their active substance such as Adjisept, AntiFlu, Astrasept, Gorpils, Koldar, Contact 400, Orinol, Rinza Lorsept, Strepsils, Suprima ENT, Terasil, TheraFlu Extratab.

Coldact contraindications

Treatment with the drug is not prescribed for hypersensitivity to one of its components, with severe atherosclerosis of the coronary arteries, with arterial hypertension, with diabetes mellitus, thyrotoxicosis and angle-closure glaucoma. The drug is also contraindicated in patients suffering from kidney, liver, heart, and severe bladder diseases, as well as in patients with stomach and duodenal ulcers, pancreatic disease, and glucose-6-phosphate dehydrogenase deficiency. You should not take the medicine in case of difficulty urinating due to prostate adenoma and diseases of the blood system, as well as for pregnant women and during lactation. Coldact Flu plus is not prescribed to children under 12 years of age, Coldact Broncho is not prescribed to children under 6 years of age, Coldact Lorpis is not prescribed to children under 5 years of age.

Latin name: Coldact Flu Plus
ATX code: N02B E51
Active substance: paracetamolum
phenylephrinum, chlorphenaminum
Manufacturer: NATUR PRODUCT EU
(Netherlands), RANBAXY (India)
Conditions for dispensing from a pharmacy: Over the counter

Coldact Flu Plus – complex drug, helping to cope with the symptoms of colds. Facilitates breathing, eliminating nasal congestion and discharge, reduces fever, pain syndromes, manifestations of allergies. Lorpils differs from the previous drug Koldakta dosage form– Available in capsules with prolonged action.

Indications for use

The drug is used in symptomatic therapy as a means first aid, as well as for removing individual symptoms ailments – different kinds pain, elevated temperature, feverish conditions. It is used to relieve symptoms of influenza, acute respiratory infections, ARVI, allergic and vasomotor rhinitis.

Composition of the drug

One capsule of the medicine contains: 200 mg of paracetamol, 8 mg of chlorphenamine (in the form of maleate), 25 mg of phenylephrine (in the form of hydrochloride).

Other components of the drug are talc, ethylcellulose, povidone, hypromellose, water, sodium compounds, food coloring, gelatin and other substances. The filling of the capsules is made of sucrose and molasses.

Medicinal properties

The therapeutic effect of Coldact Flu is due to the properties of its active components:

• Paracetamol has antipyretic, analgesic and mild anti-inflammatory properties. The substance inhibits prostaglandins and affects the part of the brain responsible for thermoregulation of the body. Thanks to this action, after taking the drug, the temperature decreases and various types of pain characteristic of colds are relieved.
• Phenylephrine has a vasoconstrictor effect and has an antiallergic effect. Mainly used for elimination and prevention stagnation. The substance relieves swelling and inflammation of the mucous tissues of the respiratory tract and sinuses.
• Chlorphenamine is a antihistamines. Affects certain receptors and thereby removes allergic reactions– reduces nasal discharge and lacrimation.

The therapeutic effect of the drug manifests itself within an hour after administration and persists throughout the day.

Release forms

Average cost – 180 rubles.

Extended-release capsules are hard gelatin pills in a transparent shell, one part of which is colorless, the other is bright red. The contents of the capsules are multi-colored granules. The product is packaged in 10 pieces per contour package. A cardboard pack contains one plate and an insert-annotation.

Mode of application

• Children (12+) and adults take one capsule every 12 hours. The course of treatment is 3-5 days.
• If the product is used to reduce fever, then it can be used for no more than 3 days, and as a pain reliever - no more than 5.

It is not recommended to independently prolong the use of Koldakt or increase its dose. Further use of the drug must be agreed with your doctor.

During pregnancy and breastfeeding

Contraindications

Coldact Flu should not be taken if you have:

• Individual hypersensitivity to at least one component
• Children's age (up to 12 years)
• Diabetes
• Peptic ulcers of the gastrointestinal tract
• Arterial hypertension
• Severe pathologies of the liver, kidneys
• Heart diseases
• Bladder problems
• Hyperactivity thyroid gland(thyrotoxicosis)
• Blood diseases, hematopoietic disorders
• Pathologies of the pancreas
• Angle-closure glaucoma
• Anemia
• G-6-PD deficiency
• Atherosclerosis of the coronary arteries.

For bronchial asthma and COPD, taking the medication should be agreed with a doctor and carried out under his supervision.

Precautionary measures

Considering that Koldakt contains paracetamol, you should be careful when taking it:

• If other drugs are taken with paracetamol at the same time, it is necessary to monitor their dosage so as not to exceed daily norm substances.
• You should not take the drug without a medical prescription if the patient must take MAO inhibitors.
• When treating with Koldakt, you should avoid alcoholic drinks and alcohol-containing medications.
• At long-term use The drug will need to check blood counts and liver condition.
• During Koldakt therapy, it is advisable to refrain from driving or operating machinery that requires quick reaction and concentration.
• The medicine may cause bronchospasm in people intolerant to acetylsalicylic acid.

If after using the medication the condition does not improve, persists, or even worsens, you should definitely consult a therapist.

Cross-drug interactions

When taking Coldact Flu, you should remember that its components react with substances of other drugs:

• When combined with Metoclopramide, the absorption of paracetamol increases, and when taken with Cholestyramine, it worsens.
• Coldact can slow down the removal of antibiotics from the body and reduce the effect of diuretics.
• Anticonvulsants increase the toxic effects of paracetamol on the liver.
• The effect of chlorpheniramine increases when taken with drugs that affect the functioning of the brain (hypnotics, sedatives, tranquilizers, barbiturates, etc.). The substance itself enhances the effect of antispasmodics, drugs for the treatment of parkinsonism, and some antidepressants.
• Phenylephrine can provoke a hypertensive crisis or arrhythmia if used with adrenergic agonists and MAO inhibitors.

Side effects

As a rule, Koldakt is normally perceived by the body. Undesirable side effects appear as:

• Nausea, heartburn, vomiting, dry mouth
• Decreased appetite
• Abdominal pain
• Stool disorders, urinary retention (occasionally), flatulence
• Difficulty breathing, pain in the heart area
• Skin reactions, angioedema(rarely)
• Lethargy, dizziness and headache
• Increased irritability, nervousness
• Tinnitus
• Visual impairment, dry eyes, increased intraocular pressure
• Anaphylactic shock
• Tachycardia, shortness of breath
• Increased blood pressure.

With the development of any discomfort the drug should be discontinued and consult a doctor.

Overdose

Taking too high doses of Koldakt can cause unpredictable consequences. Therefore, if an overdose of medication occurs, you should not hesitate to consult a doctor - you must call as soon as possible ambulance regardless of whether there are symptoms of poisoning or not.

Symptoms of paracetamol intoxication develop if the drug content exceeds 10-15 g. Overdose manifests itself:

• Pale skin
• Nausea, bouts of vomiting
• Abdominal pain
• Dizziness
• Nervous excitement
• Disorientation
• Insomnia.

Failures in the functioning of the heart and the development of pancreatitis are also possible.

In the case of simultaneous use of alcohol and Coldacta tablets, Flu develops. severe violations liver function, which, if the condition worsens, can provoke coma, and then - death. Moreover, signs of organ damage may not be felt for 12-48 hours after taking the pills.

If the patient has taken high doses for a long time, then the overdose manifests itself in the form of aplastic anemia, a decrease in blood components, and a decrease in their concentration.

An overdose of finylephrine and chlopheniramine manifests itself heavy sweating, nervous excitement or a depressed state, headaches, drowsiness, confusion, high blood pressure, rapid heartbeat, convulsions.

Conditions and shelf life

The drug is suitable for use for 2 years from the date of production. To avoid loss medicinal properties it must be stored in a dark place, away from heat and out of reach of children, at temperatures up to 25 ° C.

Analogs

To select an identical product with a similar effect and therapeutic effect you need to see a doctor.

Novartis (Türkiye)

Price– 165-230 rub.

The medicinal product contains the same components as Koldakt, has similar action. Approved for use by adults and adolescents from 12 years of age.

The drug is available in the form of coated tablets. Packaged in blister packs of 10 pieces. The application scheme differs from Koldakt:

• Adults are allowed to drink 1-2 pieces. after 4-6 hours (maximum - 6 tablets per day)
• Children and teenagers (12-18 years old) – 1 pc. once every 4-6 hours (maximum – 4 tablets).

Advantages:

• High efficiency
• It works quickly.

Flaws:

• Many contraindications
• It is necessary to monitor the intake of other medications
• Side effects.