Pentalgin isn instructions for use. Pentalgin ® -icn (Pentalgin-icn). Description of the active components of the drug "Pentalgin ® -icn"

Caffeine.

Additional ingredients: povidone, potato starch, calcium stearate and stearic acid.

Release form

Pentalgin ICN is produced in the form of tablets packed in packs of 12 pieces.

pharmachologic effect

The medicine is showing analgesic, antipyretic And anti-inflammatory action.

Pharmacodynamics and pharmacokinetics

This combination drug is characterized analgesic, antipyretic And anti-inflammatory action that is caused Metamizole And Naproxen .

Thanks to caffeine, the general well-being of patients improves, it decreases. can enhance the effect of treatment Metamizole sodium And Paracetamol . Codeine shows antitussive action by suppressing excitability in the cough center. Painkiller the action of this drug is due to a significant excitation of opiate receptors in peripheral tissues and the nervous system, which stimulates the antinoceceptive system and changes in emotional pain perception.

Indications for use

As a rule, Pentalgin ICN is prescribed for:

• moderately pronounced and weak pain sensations of various origins, affecting the joints, muscles, lumbar region;
• menstrual pain;
• dental and , ;
• colds , which are accompanied .

Contraindications

Tablets are not prescribed for:

• sensitivity to their components;
• severe disorders of the liver and kidneys;
• bronchospasm;
• peptic ulcer of the stomach and duodenum;
• oppression of hematopoiesis;
• conditions accompanied by respiratory depression;
• high intracranial pressure, traumatic brain injury;
• acute;
• cardiac arrhythmias;
• elevated;
• alcohol intoxication;
• under the age of 12;
• deficiency of glucose-6-phosphate dehydrogenase;
• , .

Side effects

Taking pills can lead to the development of heart failure, nausea and vomiting, hematopoietic disorders in the form leukopenia, granulocytopenia or .

Instructions for use of tablets Pentalgin ICN (Method and dosage)

According to the instructions, Pentalgin ICN can be taken 1 tablet no more than 3 times a day. In this case, the daily dosage should not be more than 4 tablets.

It should be noted that this drug can be taken for pain relief for no more than 5 days, and for fever reduction - up to 3 days. Continuation of treatment beyond this period is possible only after a doctor's prescription.

Overdose

Long-term use of tablets in high doses can lead to disruption of the liver and kidneys, , decrease in the speed of psychomotor reactions. In addition, prolonged uncontrolled use of the drug in high dosages is addictive, and the presence of codeine in its composition is drug dependence.

An overdose usually occurs nausea, vomiting, gastralgia, arrhythmia, depression of the respiratory center.

Therapy includes gastric lavage, intake of intestinal adsorbents and other symptomatic treatment.

Interaction

The combination of Pentalgin-ICN with drugs that have a depressant effect on the nervous system can increase the inhibition of work and the severity of the sedative effect on the respiratory center and other systems and organs. Metamizole sodium reduces the concentration , displaces oral hypoglycemic agents from the protein bond, , indirect anticoagulants, significantly increasing their activity. , tricyclic antidepressants, some contraceptives can disrupt metamizole sodium in the liver and increase its toxicity.

Simultaneous use with other non-opioid drugs often enhances toxic effects.

Weaken the action of metamizole sodium can barbiturates, phenylbutazone and various microsomal hepatic inducers.

special instructions

If the tablets are taken for a long time, that is, more than 7 days, patients need to monitor the state of the peripheral and liver activity.

Taking Pentalgin-ICN may affect the results of various doping control tests in people involved in sports.

It has been established that this medicine can make it difficult to make an accurate diagnosis in acute abdominal pain syndromes.

Treatment of patients with various forms of atopic hay fever with this drug may lead to the development of hypersensitivity reactions.

Terms of sale

Over the counter.

Storage conditions

Tablets are stored in a dry, cool and dark place, protected from children.

Best before date

Analogues Pentalgin ICN

This action is typical for: , And Analgin.

Alcohol

The combination with alcohol often increases the severity of side effects, as well as the effect on psychomotor reactions.

Pentalgin-ICN Tablets - blister pack 12, carton pack 1 - EAN code: 4601669001443 - № Р N000343/01, 2010-07-02 from Pharmstandard-Leksredstva (Russia)

Latin name

Active substance

ATX

Pharmacological group

Nosological classification (ICD-10)

Composition and form of release

1 tablet contains metamizole sodium and paracetamol 0.3 g each, caffeine 0.05 g, codeine phosphate 0.008 g and phenobarbital 0.01 g - in a blister pack of 10 pcs., in a carton pack of 1 or 2 packs or 12 pcs., in a cardboard box 1 pack.

pharmachologic effect

Inhibits cyclooxygenase and inhibits the biosynthesis of PG (analgin and paracetamol), stimulates opiate receptors, activates the antinociceptive system (codeine). Depresses (sedative effect) of the central nervous system (phenobarbital). Caffeine increases the permeability of histohematic membranes and increases the concentration of other components in the central nervous system.

Indications for Pentalgin-ICN

Moderate pain syndrome: headache and toothache, migraine, neuralgia, myalgia, arthralgia, primary dysmenorrhea - fever.

Contraindications

Hypersensitivity (including to individual components), pulmonary insufficiency, acute attack of bronchial asthma, respiratory failure due to depression of the respiratory center, impaired liver and / or kidney function.

Use during pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects

From the nervous system and sensory organs: drowsiness, lethargy, decreased concentration.

From the side of the cardiovascular system and blood (hematopoiesis, hemostasis): granulocytopenia, agranulocytosis.

From the digestive tract: dyspepsia, pain in the epigastric region, erosive and ulcerative lesions of the gastrointestinal tract.

Allergic reactions: skin rash.

Interaction

Enhances the inhibitory effect of ethanol on the central nervous system.

Dosage and administration

Inside - 1 table. 1-3 times a day. The course of treatment depends on the effectiveness of therapy and, as a rule, does not exceed 5 days.

Precautionary measures

With prolonged use, it is necessary to control the composition of peripheral blood. The concomitant use of alcohol should be avoided.

Storage conditions of Pentalgin-ICN

Keep out of the reach of children.

Shelf life of Pentalgin-ICN

Last update of the description by the manufacturer

Other options for packaging the drug - Pentalgin-ICN.

Pentalgin-ICN Tablets - blister pack 10, carton pack 1- EAN code: 4601669000927- № Р N000343/01, 2010-07-02 from Pharmstandard-Leksredstva (Russia) Pentalgin-ICN Tablets - blister pack 10, carton pack 2 - EAN code: 4601669000910- No. R N000343/01, 2010-07-02 from Pharmstandard-Leksredstva (Russia) Pentalgin-ICN Tablets - blister pack 12, carton pack 1- EAN code: 4601669001443- No. R N000343/01, 2010 -07-02 from Pharmstandard-Leksredstva (Russia) Pentalgin-ICN Tablets - blister pack 12, cardboard pack 2- No. Р N000343/01, 2010-07-02 from Pharmstandard-Leksredstva (Russia) Pentalgin-ICN Tablets - contour pack cell 6, carton pack 1- No. P N000343/01, 2010-07-02 from Pharmstandard-Leksredstva (Russia) Pentalgin-ICN Tablets - blister pack 6, carton pack 2- No. P N000343/01, 2010-07-02 from Pharmstandard-Leksredstva (Russia) Pentalgin-ICN Tablets - blister pack 10, cardboard box 500- № Р N000343/01, 2010-07-02 from Pharmstandard-Leksredstva (Russia) Pentalgin-ICN Tablets - blister pack 12, box cardboard box 500- No. R N000343/01, 2010-07-02 from Pharmstandard-Leksredstva (Russia) Pentalgin-ICN Tablets - blister pack 6, cardboard box 500- No. R N000343/01, 2010-07-02 from Pharmstandard-Leksredstva (Russia)

Tablets - 1 tab.:

• Active substances: paracetamol - 300 mg; metamizole sodium - 300 mg; caffeine - 50 mg; phenobarbital - 50 mg; codeine phosphate - 8 mg;
• Excipients: potato starch, povidone (polyvinylpyrrolidone low molecular weight medical), stearic acid, calcium stearate.

6, 10 or 12 pcs. - cellular contour packings (1, 2, 500) - packs of cardboard.

Description of the dosage form

Tablets from white to white with a yellow or cream tint, biconvex, in the form of a capsule with flat side surfaces, scored on one side and engraved "PENTALGIN" on the other.

pharmachologic effect

Analgesic-antipyretic combined composition.

Pharmacokinetics

Data on the pharmacokinetics of the drug Pentalgin®-ICN are not provided.

Pharmacodynamics

Combined drug, has analgesic, antipyretic, anti-migraine effect.

Paracetamol is an analgesic-antipyretic. Blocks COX mainly in the central nervous system, affecting the centers of pain and thermoregulation; has analgesic and antipyretic effect.

Metamizole sodium is an analgesic-antipyretic, a derivative of pyrazolone. It has a pronounced analgesic effect.

Caffeine is a psychostimulant, improves the well-being of patients and reduces headaches of vascular origin (including migraine).

Phenobarbital is a barbiturate that increases the analgesic efficacy of metamizole sodium and paracetamol.

Codeine has an analgesic effect due to the excitation of opioid receptors in various parts of the central nervous system, leading to stimulation of the antinociceptive system and a change in the emotional perception of pain.

Indications for use Pentalgin-icn

• pain syndrome of various origins of low and moderate intensity (including arthralgia, myalgia, sciatica, algodismenoria, neuralgia, headache, toothache);
• colds and conditions accompanied by febrile syndrome.

Contraindications to the use of Pentalgin-icn

• severe liver failure;
• severe renal failure;
• bronchial asthma;
• anemia, leukopenia;
• conditions accompanied by respiratory depression;
• craniocerebral hypertension;
• acute myocardial infarction;
• arrhythmias;
• glaucoma;
• alcohol intoxication;
• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• lactation period (breastfeeding);
• children's age up to 12 years;
• hypersensitivity to the components of the drug.

With caution, the drug should be used for gastric ulcer and duodenal ulcer in remission, with arterial hypertension, in elderly patients.

Pentalgin-icn Use in pregnancy and children

Use during pregnancy and lactation (breastfeeding) is contraindicated.

Contraindication: children under 12 years of age.

Pentalgin-icn side effects

From the side of the central nervous system: dizziness, drowsiness.

From the side of the cardiovascular system: palpitations, tachycardia.

From the digestive system: nausea, vomiting, constipation.

From the hemopoietic system: leukopenia, granulocytopenia, agranulocytosis.

Allergic reactions: rash, itching, urticaria.

Others: with prolonged uncontrolled intake in high doses - addiction (weakening of the analgesic effect), drug dependence (codeine), liver and / or kidney failure.

drug interaction

With the simultaneous use of drugs that have a depressing effect on the central nervous system (including sedatives and tranquilizers), an increase in the severity of the sedative effect and a depressant effect on the respiratory center is likely. Enhances the effect of ethanol on the psychomotor reaction. Metamizole sodium reduces the concentration of cyclosporine.

Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin from the connection with the protein, increases their activity. Tricyclic antidepressants, oral contraceptives, allopurinol disrupt the metabolism of metamizole sodium in the liver and increase its toxicity.

Simultaneous use of the drug Pentalgin®-ICN with other non-opioid analgesics may lead to increased toxic effects.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of metamizole sodium.

When taking the drug Pentalgin®-ICN, it is possible to change the results of doping control tests in athletes.

Taking the drug Pentalgin®-ICN makes it difficult to establish a diagnosis in acute abdominal pain syndrome.

In patients suffering from atopic bronchial asthma, hay fever, there is an increased risk of developing hypersensitivity reactions.

Influence on the ability to drive vehicles and control mechanisms

When using the drug, patients should refrain from potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Instructions for the medical use of the drug

Description of the pharmacological action

Inhibits cyclooxygenase and inhibits the biosynthesis of PG (analgin and paracetamol), stimulates opiate receptors, activates the antinociceptive system (codeine). Depresses (sedative effect) of the central nervous system (phenobarbital). Caffeine increases the permeability of histohematic membranes and increases the concentration of other components in the central nervous system.

Indications for use

Pain syndrome of various origins of low and moderate intensity (including arthralgia, myalgia, sciatica, algodismenoria, neuralgia, headache, toothache);

Colds and conditions accompanied by febrile syndrome.

Release form

pills; blister pack 10 carton pack 1;

Pills; blister pack 10 carton pack 2;

Pills; blister pack 12 carton pack 1;

Pills; blister pack 12 carton pack 2;

Pills; blister pack 6 carton pack 1;

Pills; blister pack 6 carton pack 2;

Pills; blister packaging 10 cardboard box 500;

Pills; blister pack 12 cardboard box 500;

Pills; blister packaging 6 cardboard box 500;

Pharmacodynamics

Combined drug, has analgesic, antipyretic, anti-migraine effect.

Paracetamol is an analgesic-antipyretic. Blocks COX mainly in the central nervous system, affecting the centers of pain and thermoregulation; has analgesic and antipyretic effect.

Metamizole sodium is an analgesic-antipyretic, a derivative of pyrazolone. It has a pronounced analgesic effect.

Caffeine is a psychostimulant, improves the well-being of patients and reduces headaches of vascular origin (including migraine).

Phenobarbital is a barbiturate that increases the analgesic efficacy of metamizole sodium and paracetamol.

Codeine has an analgesic effect due to the excitation of opioid receptors in various parts of the central nervous system, leading to stimulation of the antinociceptive system and a change in the emotional perception of pain.

Pharmacokinetics

Data on the pharmacokinetics of the drug Pentalgin-ICN are not provided.

Use during pregnancy

Use during pregnancy and lactation (breastfeeding) is contraindicated.

Contraindications for use

severe liver failure;
- severe renal failure;
- bronchial asthma;
- anemia, leukopenia;
- conditions accompanied by respiratory depression;
- craniocerebral hypertension;
- acute myocardial infarction;
- arrhythmias;
- glaucoma;
- alcohol intoxication;
- deficiency of glucose-6-phosphate dehydrogenase;
- pregnancy;
- lactation period (breastfeeding);
- children's age up to 12 years;
- Hypersensitivity to the components of the drug.

With caution, the drug should be used for gastric ulcer and duodenal ulcer in remission, with arterial hypertension, in elderly patients.

Side effects

From the side of the central nervous system: dizziness, drowsiness.

From the side of the cardiovascular system: palpitations, tachycardia.

From the digestive system: nausea, vomiting, constipation.

From the hemopoietic system: leukopenia, granulocytopenia, agranulocytosis.

Allergic reactions: rash, itching, urticaria.

Others: with prolonged uncontrolled intake in high doses - addiction (weakening of the analgesic effect), drug dependence (codeine), liver and / or kidney failure.

Dosage and administration

Overdose

Symptoms: nausea, vomiting, gastralgia, tachycardia, arrhythmia, depression of the respiratory center.

Treatment: gastric lavage, administration of intestinal adsorbents, if necessary, symptomatic therapy.

Interactions with other drugs

Enhances the inhibitory effect of ethanol on the central nervous system.

Precautions for use

With prolonged use, it is necessary to control the composition of peripheral blood. The concomitant use of alcohol should be avoided.

Special instructions for admission

With prolonged (more than 1 week) treatment, it is necessary to control the pattern of peripheral blood and the functional state of the liver.

When taking the drug Pentalgin-ICN, it is possible to change the results of doping control tests in athletes.

Taking the drug Pentalgin®-ICN makes it difficult to establish a diagnosis in acute abdominal pain syndrome.

In patients suffering from atopic bronchial asthma, hay fever, there is an increased risk of developing hypersensitivity reactions.

Influence on the ability to drive vehicles and control mechanisms

When using the drug, patients should refrain from potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Storage conditions

List B.: In a dry, dark place.

Best before date

Belonging to ATX-classification:

** The Medication Guide is for informational purposes only. For more information, please refer to the manufacturer's annotation. Do not self-medicate; Before you start using Pentalgin-ICN, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace the advice of a doctor and cannot serve as a guarantee of the positive effect of the drug.

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Combined drug, has analgesic, antipyretic, anti-migraine effect.

Paracetamol is an analgesic-antipyretic. Blocks COX mainly in the central nervous system, affecting the centers of pain and thermoregulation; has analgesic and antipyretic effect.

Metamizole sodium is an analgesic-antipyretic, a derivative of pyrazolone. It has a pronounced analgesic effect.

Caffeine is a psychostimulant, improves the well-being of patients and reduces headaches of vascular origin (including migraine).

Phenobarbital is a barbiturate that increases the analgesic efficacy of metamizole sodium and paracetamol.

Codeine has an analgesic effect due to the excitation of opioid receptors in various parts of the central nervous system, leading to stimulation of the antinociceptive system and a change in the emotional perception of pain.

Pharmacokinetics

Release form

Tablets from white to white with a yellow or cream tint, biconvex, in the form of a capsule with flat side surfaces, scored on one side and engraved "PENTALGIN" on the other.

Excipients: potato starch, povidone (polyvinylpyrrolidone low molecular weight medical), stearic acid, calcium stearate.

6 pcs. - cellular contour packings (1) - packs of cardboard.
6 pcs. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
12 pcs. - cellular contour packings (1) - packs of cardboard.
12 pcs. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (500) - cardboard boxes.
12 pcs. - cellular contour packings (500) - cardboard boxes.
6 pcs. - cellular contour packings (500) - cardboard boxes.

Dosage

Assign 1 tab. 1-3 times / day. The maximum daily dose is 4 tab.

The drug should not be taken for more than 5 days as an anesthetic and for more than 3 days as an antipyretic without a doctor's prescription and supervision.

Overdose

Symptoms: nausea, vomiting, gastralgia, tachycardia, arrhythmia, depression of the respiratory center.

Treatment: gastric lavage, administration of intestinal adsorbents, if necessary, symptomatic therapy.

Interaction

With the simultaneous use of drugs that have a depressing effect on the central nervous system (including sedatives and tranquilizers), an increase in the severity of the sedative effect and a depressant effect on the respiratory center is likely. Enhances the effect of ethanol on the psychomotor reaction. Metamizole sodium reduces the concentration of cyclosporine.

Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin from the connection with the protein, increases their activity. Tricyclic antidepressants, oral contraceptives, allopurinol disrupt the metabolism of metamizole sodium in the liver and increase its toxicity.

Simultaneous use of the drug Pentalgin ® -ICN with other non-opioid analgesics may lead to increased toxic effects.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of metamizole sodium.

Side effects

From the side of the central nervous system: dizziness, drowsiness.

From the side of the cardiovascular system: palpitations, tachycardia.

From the digestive system: nausea, vomiting, constipation.

From the hemopoietic system: leukopenia, granulocytopenia, agranulocytosis.

Allergic reactions: rash, itching, urticaria.

Others: with prolonged uncontrolled intake in high doses - addiction (weakening of the analgesic effect), drug dependence (codeine), liver and / or kidney failure.

Indications

• pain syndrome of various origins of low and moderate intensity (including arthralgia, myalgia, sciatica, algodismenoria, neuralgia, headache, toothache);
• colds and conditions accompanied by febrile syndrome.

Contraindications

• severe liver failure;
• severe renal failure;
• bronchial asthma;
• anemia, leukopenia;
• conditions accompanied by respiratory depression;
• craniocerebral hypertension;
• acute myocardial infarction;
• arrhythmias;
• glaucoma;
• alcohol intoxication;
• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• lactation period (breastfeeding);
• children's age up to 12 years;
• hypersensitivity to the components of the drug.

With caution, the drug should be used for gastric ulcer and duodenal ulcer in remission, with arterial hypertension, in elderly patients.

Application features

Use during pregnancy and lactation

Application for violations of liver function

Application for violations of kidney function

Use in children

Use in elderly patients

The drug should be used with caution in elderly patients.

special instructions

With prolonged (more than 1 week) treatment, it is necessary to control the pattern of peripheral blood and the functional state of the liver.

When taking the drug Pentalgin ® -ICN, it is possible to change the results of doping control tests in athletes.

Taking the drug Pentalgin ® -ICN makes it difficult to establish a diagnosis in acute abdominal pain syndrome.

In patients suffering from atopic bronchial asthma, hay fever, there is an increased risk of developing hypersensitivity reactions.

Influence on the ability to drive vehicles and control mechanisms

When using the drug, patients should refrain from potentially hazardous activities that require increased attention and speed of psychomotor reactions.