Antifungal cream "Clotrimazole": instructions for use. Clotrimazole - instructions, use, analogues, indications for use

Antifungal agent for local application from the group of imidazole derivatives.

White crystalline substance, odorless. Practically insoluble in water, sparingly soluble in ether, very soluble in polyethylene glycol 400, ethanol and chloroform. Molecular mass 344,84.

Pharmacology

It disrupts the synthesis of ergosterol (the main structural component of the fungal cell membrane), changes the permeability of the fungal membrane, promotes the release of potassium and intracellular phosphorus compounds from the cell and the breakdown of cellular nucleic acids. Inhibits the synthesis of triglycerides and phospholipids. Reduces the activity of oxidative and peroxidase enzymes, as a result of which the intracellular concentration of hydrogen peroxide increases to a toxic level, which contributes to the destruction of cellular organelles and leads to cell necrosis. Depending on the concentration, it exhibits a fungicidal or fungistatic effect. Inhibits blastospore transformation Candida albicans into an invasive mycelial form.

Clotrimazole acts mainly on growing and dividing microorganisms. In vitro exhibits fungicidal and fungistatic activity against dermatomycetes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast-like fungi Candida spp.(including Candida albicans). Active against pathogen versicolor — Pityrosporum orbiculare(Malassezia furfur).

Fungal strains that are naturally resistant to clotrimazole are rare. Primary resistance to clotrimazole has only been described for Candida guillermondii.

Effective against gram-positive bacteria - the causative agent of erythrasma Corynebacterium minutissimum, and Staphylococcus spp., Streptococcus spp., gram-negative bacteria - Bacteroides, Gardnerella vaginalis. In high concentrations it is active against Trichomonas vaginalis.

Poorly absorbed through the skin and mucous membranes.

Accumulates in the stratum corneum of the epidermis, the concentration in the deep layers of the epidermis is higher than the MIC for dermatomycetes. When applied to nails, it is found in keratin.

When intra vaginal insertion 3-10% of the dose is absorbed.

In the liver it is quickly biotransformed to inactive metabolites and excreted in feces. Absorbed clotrimazole induces the activity of microsomal liver enzymes, which leads to an acceleration of its catabolism.

High concentrations in vaginal secretions and low concentrations remain in the blood for 48-72 hours.

Carcinogenicity, mutagenicity, effect on fertility

There was no evidence of carcinogenicity of clotrimazole in a study in rats receiving it orally for 18 months. Long-term studies in animals have not been conducted to assess the potential carcinogenicity of clotrimazole when administered intravaginally.

A study of mutagenicity in Chinese hamsters that received 5 doses of clotrimazole 100 mg/kg orally did not reveal a mutagenic effect - structural changes during metaphase in the spermatophore chromosomes.

Pregnancy. In studies in pregnant rats, intravaginal administration of doses of clotrimazole up to 100 mg/kg did not reveal any adverse effects on the fetus. However, daily oral administration Clotrimazole at doses ranging from 50 to 120 mg/kg resulted in embryotoxicity in rats and mice (possibly secondary to maternal toxicity). Thus, in mice, when taking clotrimazole in doses 120 times higher than the usual dose in humans, in the period from 9 weeks before mating to the end of feeding, mating disruption, a decrease in the number of viable pups, and a decrease in the survival rate of offspring from birth to the end of feeding were recorded. At doses up to 60 times the normal human dose, no adverse effects were observed. In rats, at doses 50 times higher than the usual human dose, clotrimazole, over a similar observation period, caused a slight decrease in the number of pups in the litter and a decrease in their survival. No teratogenic effects were detected in mice, rabbits and rats when clotrimazole was taken orally at doses up to 200, 180 and 100 mg/kg, respectively.

Use of the substance Clotrimazole

Fungal infections of the skin and mucous membranes: dermatomycosis, dermatophytosis, trichophytosis, epidermophytosis, microsporia, candidiasis, interdigital fungal erosion, fungal paronychia; mycoses complicated by secondary pyoderma; lichen versicolor, erythrasma; candidal stomatitis; candidiasis vulvitis, vulvovaginitis, balanitis, trichomoniasis; for rehabilitation birth canal before childbirth.

Contraindications

Hypersensitivity.

Use during pregnancy and breastfeeding

Should not be used in the first trimester of pregnancy (adequate and strictly controlled studies have not been conducted). When used intravaginally in women in II and III trimesters During pregnancy, no adverse effects on the fetus have been identified, but the use of a vaginal applicator is undesirable.

With caution - during breastfeeding (it is unknown whether clotrimazole penetrates into breast milk).

Side effects of the substance Clotrimazole

Allergic reactions (itching, urticaria).

When applied topically to the skin: erythema, blistering, swelling, burning and tingling, irritation and peeling of the skin.

When used topically for the treatment of urogenital infections: itching, burning, hyperemia and swelling of the mucous membrane, vaginal discharge, frequent urination, intercurrent cystitis, burning sensation in the partner’s penis, pain during sexual intercourse.

When applied topically in the oral cavity: redness of the oral mucosa, burning and tingling sensation at the site of application, irritation.

Interaction

Reduces the activity (mutually) of polyene antibiotics (amphotericin B, nystatin, natamycin).

Overdose

In case of accidental ingestion of drugs, the following are possible: symptoms: anorexia, nausea, vomiting, gastralgia, liver dysfunction; rarely - drowsiness, hallucinations, pollakiuria, skin allergic reactions.

Treatment: reception activated carbon, symptomatic therapy.

Routes of administration

Locally.

Precautions for the substance Clotrimazole

Avoid contact of the drug with the mucous membrane of the eyes. Avoid use in areas where integrity is compromised skin.

After applying the cream, do not use sealed dressings.

To prevent reinfection it is recommended simultaneous treatment sexual partner. Do not prescribe intravaginally during menstruation. For trichomoniasis, combined use with systemic chemotherapeutic agents (metronidazole orally) is recommended.

In patients with impaired liver function, its functional state should be periodically monitored.

The appearance of irritation or signs of hypersensitivity requires discontinuation of treatment.

If there is no clinical improvement within 4 weeks, a microbiological examination to confirm the diagnosis and exclude another cause of the disease.

Interactions with other active ingredients

Trade names

The drug Clotrimazole cream is used for pathologies caused by fungus, for example, vaginal candidiasis or thrush. Basics active substance The product destroys fungal membranes and has a detrimental effect on pathogenic microorganisms. Thanks to the low price and positive feedback, this medicine against fungus is one of the leaders in the pharmacological market.

What is Clotrimazole cream

For fungal diseases of the skin, nails, vaginal candidiasis (thrush) it is prescribed drug therapy antibacterial ointment Clotrimazole. The drug has a strong antifungal effect on pathogens of erythrasma, fungal psoriasis and other common mycotic diseases. The doctor can prescribe an ointment at the first symptoms of infection, to prevent mycosis in the layers of the skin and on the vaginal mucosa.

The drug inhibits the growth, development and division of fungal cells. In addition, the drug is widely used for genital tract infections (for example, vaginal mycosis of the vaginal lining). To treat candidiasis, ointment is prescribed to both sexual partners. In this case, it is recommended to apply the cream both before and immediately after sexual intercourse.

The medicine in the form of a cream is a mass of pale yellow color, the consistency of fatty sour cream, packaged in an aluminum tube and cardboard packaging with an annotation for the medicine, instructions for using the antifungal drug. Clotrimazole ointment is freely available in pharmacies and online stores without a doctor's prescription.

Compound

The drug is available in several dosage forms: vaginal tablets, suppositories, ointment, cream for external use. The latter has the following composition:

1. The main active ingredient is clotrimazole 10 mg.
2. Additional substances – ethanol, Vaseline, glycerol, distilled water, solid fat.

pharmachologic effect

The drug disrupts the synthesis of ergosterol, which is part of the fungal cell membrane. Clotrimazole inhibits cell division processes pathogenic microorganisms and is one of the most effective antifungal agents because it has a wide spectrum of action. The drug has a detrimental effect against gram-positive and gram-negative bacteria. Doctors recommend starting therapy at the first signs infectious lesion.

What is Clotrimazole for?

Clotrimazole cream has the following readings for use:

• fungal diseases skin;
• mycoses of the feet, palms, skin folds;
• pityriasis versicolor;
• thrush;
• erythrasma;
• superficial and deep candidiasis.

Instructions for use Clotrimazole cream

The medicine Clotrimazole is used for external application for antifungal therapy. The medication, according to the instructions, is applied in a thin layer 2-3 times a day. on clean and dry areas of skin with affected epidermis. If the skin has serious lesions and ulcers, to achieve best effect It is recommended to use compresses with cream for several days so that the medicine is absorbed in high concentrations. The duration of the course of therapy depends on the severity of the disease, localization of the pathology, and effectiveness.

For women

A medicine with antifungal activity, Clotrimazole, is used for women suffering from frequent exacerbations of thrush, vaginitis and other bacterial lesions of the vagina. The duration of treatment is from 5 to 10 days, depending on the severity of the disease. Clotrimazole is recommended for the prevention of exacerbations of candidiasis during colds and reduction general immunity. The drug should be used with caution during menstruation.

For men

Clotrimazole cream for men is used mainly for the treatment of chronic and acute form candidal skin lesions of the genitals. Treatment of fungal diseases in men lasts from 4 to 7 days. It is better to start using the cream when the first signs of the disease appear: severe itching, burning, redness, pain when urinating. Good genital hygiene also helps. Do not use the cream if you are hypersensitive to the components of the drug.

Drug interactions

Some medicines(Amphotericin B, Nystatin) significantly reduce the effectiveness of Clotrimazole during simultaneous drug therapy, so they do not need to be used together. When using the medication, negative interactions with other drugs result clinical trials was not identified. Caution should be used when using the cream simultaneously with other antibiotic ointments, since the combination different groups antifungal drugs may lead to allergies.

Side effects and overdose

When using cream with Clotrimazole, local adverse reactions: itching, burning, redness of the skin at the site of application of the drug. In some cases, blisters, erythema, swelling and peeling of the skin appear. Individual intolerance to the drug is manifested by urticaria. The use of the drug in high doses does not cause life-threatening or health-threatening conditions.

Contraindications

The use of Clotrimazole is strictly contraindicated if the patient has a history of:

• insufficiency of the kidneys or the urinary system as a whole;
• increased sensitivity to the components of the drug;
• liver failure;
• open wounds on the skin;
• allergic reactions.

special instructions

The antibiotic Clotrimazole is intended strictly for external use for fungal infections and other skin diseases. The medicinal product is not suitable for use in ophthalmological practice, contact of the cream with the eyes and the skin around them should be avoided. The drug should be used with caution in children under 5 years of age. Do not allow the cream to get into open wounds or damaged mucous membranes. When the first signs appear allergic reaction drug therapy with the drug must be discontinued.

Pregnancy and lactation

No toxic effects of the drug on the fetus have been identified; use is relatively safe at all stages of pregnancy. Therapeutic doses of the drug do not affect fetal development. It is recommended to use Сlotrimazole for the prevention of fungal infections for women in the first trimester of pregnancy who have an unfavorable permanent environment (for example, if a girl works in kindergarten or medical institution). Use during breastfeeding is not prohibited if the cream does not come into contact with the mammary glands.

Analogs

Present on the pharmaceutical market a large number of medications that are similar in their effect to Clotrimazole, but differ in release form, price, and composition. Some may cause fewer side effects or work faster. The main analogues of Clotrimazole are:

1. Candide. An antifungal medication that has a wide spectrum of action against fungal microorganisms. The main active substance of Candida, clotrimazole, is a form of the substance imidazole. Due to the fact that the drug damages the membranes of fungal cells, according to reviews, it is considered one of the best antifungal agents. The cost of the medicine is about 80 rubles.
2. Kanizon. The drug has fungistatic and fungicidal effects, the manifestation of which depends on the doses of the drug used. The following groups of fungi are sensitive to the drug Kanizon: dermatophytes, moldy fungi, blastomycetes and dysmorphic fungi, actinomycetes. The active component inhibits the synthesis of molecules of the substance ergosterol, which is necessary for the formation of cell walls of pathogenic microorganisms. The price of the medicine is on average 75 rubles per package.

Sage essential extract.

Compound cream 1%: clotrimazole at a concentration of 10 mg/g, cetostearyl and benzyl alcohols, polysorbate 60, synthetic spermaceti, octyldodecanol, sorbitan stearate, water.

Compound ointments 1%: clotrimazole at a concentration of 10 mg/g, polyethylene oxides 400 and 1500, propylene glycol, methylparaben, nipagin.

Compound solution 1%: clotrimazole at a concentration of 10 mg/ml (calculated on dry matter), polyethylene glycol 400, propylene glycol, ethanol 96%.

Compound candles: one suppository contains 100 mg of active substance and base in the volume necessary to obtain a suppository weighing 2 g. Clotrimazole suppositories contain semi-synthetic glycerides as a base.

Compound tablets: 100, 200 or 500 mg clotrimazole, lactose monohydrate, potato starch, adipic acid, sodium bicarbonate, silicon dioxide in colloidal form, sodium lauryl sulfate.

Release form

• gel 1% (pack of 20 and 40 g);
• cream 1% (tubes 15, 20, 30 and 50 g);
• ointment 1% (tubes 15, 20, 30 and 40 g);
• 1% solution (15 ml bottles);
• vaginal suppositories 0.1 g (package No. 6);
• vaginal tablets 0.1, 0.2 or 0.5 g (packaging No. 1, No. 3, No. 6; tablets are equipped with an applicator).

Tablets and vaginal suppositories Clotrimazole has an ATC code different from other dosage forms of the drug - G01AF02.

Clotrimazole can also be produced in the form of granules, powder for external use, or spray.

The drug is intended for local (including intravaginal) and external use; tablets for oral administration are not available.

pharmachologic effect

Antimycotic.

Pharmacodynamics and pharmacokinetics

Clotrimazole is a derivative imidazole .

In vitro shows high activity against the most pathogenic fungi which can cause serious infectious complications, namely:

• dermatophytes (Microsporum sp., Epidermophyton floccosum, Trichophyton sp.);
• yeast-like fungi (Cryptococcus neoformans, Candida sp.);
• dimorphic fungi (Histoplasma capsulatum, Paracoccidicides brasiliensis, Coccidiodes immitis).

The mechanism of action of clotrimazole is based on its ability to block the synthesis of proteins, nucleic acids and ergosterol, which is necessary for the construction of cell membranes of fungi. As a result, the cell membranes of the fungi are damaged and the cells die.

At low concentrations, clotrimazole has a fungistatic effect. If the dose exceeds 20 mcg/ml, the drug has a fungicidal effect, and not only on proliferating cells.

When used in high doses, it helps to increase the concentration of hydrogen peroxide in the fungal cell to a toxic value and, as a result, destroys the fungal cells

When applied topically, the drug is absorbed epidermis . Most high concentration substances are determined in reticuloderm . It is also able to penetrate the keratin of nails.

Clotrimazole enters the systemic circulation in very small quantities. Metabolized in the liver to inactive substances that are excreted from the body in feces and urine.

When administered intravaginally, 5 to 10% of clotrimazole is absorbed. The absorbed substance is metabolized in the liver. Metabolic products are excreted in bile.

Indications for use: what is Clotrimazole ointment, cream, gel, suppositories and tablets for?

What do Clotrimazole ointment, gel, cream and solution help with?

The drug is prescribed for treatment fungal skin infections which are caused mold and yeast fungi , dermatophytes and other pathogens sensitive to clotrimazole.

They are also used as remedies depriving caused by Malassezia furfur, And erythrasmas (causative agent - Corynebacterium minutissimum).

Clotrimazole ointment, cream, gel and solution help: from nail fungus ( , fungal paronychia ), trichophytosis , dermatophytosis , fungal erosion and diaper rash, candidiasis , , , ringworm , complicated secondary pyoderma mycoses .

Indications for the use of ointment, gel, cream and solution include: infectious diseases, pathogens that are resistant to and a number of other antifungal agents.

For treatment pityriasis rosea the drug is not suitable because this disease is most likely to have viral or infectious-allergic origin , and may also be the body’s response to a strong shock or breakdown. Clotrimazole is effective in fungal infections .

The use of Clotrimazole ointment, gel and cream with Clotrimazole in gynecology is indicated:

• for treatment and prevention ;
• for prevention repeated fungal infections of the female reproductive system , which develop with long-term treatment antibiotics or against the background of immunodeficiency conditions.

Also, solution, gel, cream and ointment in gynecology are used to sanitize the genital tract before delivery.

Candles - what are they for?

Indications for the use of vaginal suppositories are vaginal candidiasis And genital superinfections , provoked by microorganisms sensitive to clotrimazole. The drug is prescribed to women and, after the onset of sexual activity, to teenage girls.

What are Clotrimazole tablets for?

Clotrimazole tablets are used to treat blastomycotic infections of the vulva And vagina . In particular, the drug is prescribed for vaginitis caused by fungi of the genus Candida (including diseases caused by resistant to nystatin strains) caused by other pathogens sensitive to clotrimazole superinfections of the genital organs , for sanitization of the genital tract before delivery.

Contraindications

Contraindication: hypersensitivity.

Side effects

Allergic reactions.

When applied to the skin, the following side effects are possible:

• burning;
• edema;
• the appearance of blisters;
• skin irritation;
• tingling sensation
• peeling.

Local use for urogenital mycoses may be accompanied by burning, itching, swelling and hyperemia of the mucous membrane, intercurrent cystitis , the appearance of vaginal discharge, increased urination, pain during sexual intercourse.

When applied topically mycoses oral cavity Redness of the mucous membrane, tingling and burning sensation at the site of application of the drug, and irritation may be observed.

Instructions for use of Clotrimazole: Clotrimazole for women and men

Clotrimazole ointment: instructions for use. How to apply Clotrimazole ointment for men?

Before applying Clotrimazole ointment (Acri or other manufacturers), the affected areas of the body are first washed with soapy water and dried thoroughly.

The drug is applied to the affected areas (grabbing small areas healthy skin around the lesion) in a thin layer from 1 to 3 r./day. and rub lightly.

For 1 treatment of an area the size of a palm, a 5-mm strip of ointment is sufficient.

Regardless of what pathogen causes the disease, treatment after relief of subjective symptoms is recommended to continue for another 2 weeks.

At dermatomycosis the course of treatment lasts from 3 to 4, with erythrasma — from 2 to 4, with - from 1 to 3 weeks.

If there is no clinical improvement after 4 weeks regular use drug, the patient is sent for a repeat microbiological study and the treatment regimen is revised.

Using ointment for thrush in women, it helps block the spread of fungal cells and, when higher doses are prescribed, ensures their complete destruction. For therapeutic purposes, Clotrimazole from thrush use 2 times a day, rubbing the ointment into the affected areas of the perineum.

For men, method of use: thrush and others (candidal balanoposthitis , urogenital candidiasis ) the same as for women.

The ointment is applied to foreskin and the head of the penis and carefully rub into the skin and mucous membrane. Frequency of applications - 2 times/day.

The drug is poorly absorbed into the skin, and its active substance is characterized by the ability to gradually accumulate in top layer skin. Thanks to these properties it is ensured high efficiency Clotrimazole ointments for thrush in men and women.

Clotrimazole cream: instructions for use

The cream is intended for topical use. At thrush And other fungal diseases it is applied to the affected parts twice or thrice during the day and lightly rubbed.

The duration of the course depends on the indications for use and ranges from 1-2 (with candidal balanitis/vulvitis ) up to 3-4 weeks (with dermatomycosis ).

To prevent relapse of the disease, it is very important not to stop treatment for another 2 weeks after the subjective symptoms of infection disappear. If there is no improvement after 4 weeks of therapy, the patient should consult a doctor.

Vaginal cream Clotrimazole is administered into the vagina in portions of 5 grams 1 time per day. within 3 days.

Instructions for the solution

Before applying Clotrimazole, the skin should be washed with warm soapy water (especially the areas between the fingers) and dried well. The affected areas are treated 2-3 times a day. The amount of solution should be sufficient for uniform application to the entire affected surface.

If the skin of the feet is affected, liquid Clotrimazole solution must be applied after each wash.

The solution is the most preferred dosage form for onychomycosis . This is due to the fact that it has the best penetrating properties.

At fungal infections of the oral cavity the affected areas of the mucous membrane are treated cotton swab or a swab onto which drops are previously applied (10 to 20 drops are enough to treat each ear). Frequency of procedures - 3-4 rubles/day.

After applying Clotrimazole, you should refrain from eating and drinking for an hour.

Clotrimazole drops are also effective in onomycosis caused by yeast fungi. Drops are administered into the ear using turundas: a twisted cotton ball is moistened in the solution and 3-4 times a day. put in for 5-10 minutes ear canal. Treatment lasts from 3 to 4 weeks.

Instructions for the gel

The peculiarity of this dosage form is that the gel is well distributed on the skin and is also well absorbed into it. This allows the drug to be used for treating hard-to-reach areas of the body.

The gel is used intravaginally in the same way as clotrimazole cream: 1 r./day. 5 grams each. The course of treatment is 3 days.

Clotrimazole vaginal tablets: instructions for use

In the absence of other prescriptions, Clotrimazole Acri tablets and synonymous drugs for thrush and others fungal infections of the genital organs apply:

• for 3 days, 1 tablet 2 times a day;
• for 6 days, 1 tablet 1 time per day.

How to administer Clotrimazole vaginal tablets? Before administration, the tablet is removed from the package and moistened with cooled water. boiled water. The drug should be administered in the “lying on your back” position with your knees bent.

In order for the tablet to completely dissolve and clotrimazole to work, a moist environment is required (in otherwise undissolved particles may spill out). Therefore, the tablet is inserted into the vagina as deeply as possible. It is optimal to carry out the procedure before bedtime.

Treatment must be stopped before menstruation begins. Menstrual flow will wash away the drug, and it will not have any effect required action. During treatment with vaginal tablets, you should not use tampons, spermicides, intravaginal douching or any other vaginal products.

For sanitation of the genital tract Before delivery, the woman is given a single dose of 200 mg of clotrimazole.

At pregnancy the drug is contraindicated in the 1st trimester. For more later Clotrimazole does not have any adverse effects on fetal development, but the use of the applicator may be associated with certain risks.

Instructions for candles

Candles from thrush used intravaginally. The drug should be injected deep into the vagina, one dose daily for 6 days. A repeat course is possible after consulting a doctor.

Clotrimazole suppositories for thrush and others urogenital mycoses not used during menstrual bleeding. Treatment must be completed before it begins.

During pregnancy, the drug in this dosage form used from the 2nd trimester and in situations where the expected benefit to the mother exceeds possible risks for the fetus.

Reviews allow us to conclude that the drug quickly destroys fungal colonies and eliminates the unpleasant symptoms of mycoses. Its other advantages include low price and big choice dosage forms.

Overdose

When applied to the skin and intravaginally, there is a risk acute intoxication no, since clotrimazole enters the systemic circulation in very small quantities.

In case of accidental ingestion of Clotrimazole, nausea, anorexia, vomiting, gastralgia, and liver dysfunction are possible. IN in rare cases pollakiuria, hallucinations, drowsiness, and allergic skin reactions are observed.

In this case, the patient is prescribed enterosorbents and symptomatic treatment. Gastric lavage is performed in situations where a life-threatening dose was taken within the previous hour, as well as in the presence of visible symptoms overdose (nausea, dizziness, vomiting).

Interaction

At simultaneous use With polyene antibiotics ( , , ) drugs mutually suppress each other's activity.

Terms of sale

Over the counter.

Storage conditions

Protect from moisture and light. Storage temperature should not exceed 25°C. Freezing of cream, gel, ointment or solution is not allowed.

Best before date

Suppositories, cream, solution, gel and vaginal tablets are suitable for use for 3 years after the date of issue. The shelf life for the ointment is 2 years.

special instructions

Avoid ingestion and contact with eyes.

For mycoses, all affected areas of the body should be treated simultaneously.

The use of vaginal tablets, unless otherwise advised by a doctor, is contraindicated in the presence of any of the following symptoms:

• acyclic vaginal bleeding ;
• bloody discharge or abnormal bleeding from the vagina, uterine hemorrhages;
• dysuria ;
• lower abdominal pain;
• open sores, blisters, or sores of the vagina or vulva;
• any unpleasant symptoms that are associated with the use of Clotrimazole (irritation, redness, burning, swelling, etc.);
• chills or fever with a temperature above 38°C;
• nausea and/or vomiting;
• vaginal discharge with an unpleasant odor;
• pain in the shoulder or back.

To prevent reinfection, treatment is prescribed to both partners simultaneously. The optimal dosage form for men is cream.

At in addition to the drug, chemotherapy drugs are prescribed for systemic treatment ( inside).

Which is better, Clotrimazole ointment or cream?

The choice in favor of one or another dosage form is made depending on the indications. Clotrimazole ointment for women and men is prescribed for diseases that are accompanied by increased dryness and peeling of the skin.

As a rule, these are mycoses of the skin caused by dermatophytes ( trichophytosis , microsporia ), athlete's foot inguinal , erythrasma , pityriasis versicolor , individual cases , Kanizon , fungicip .

Which is better: Candide or Clotrimazole?

Candide is a synonym for Clotrimazole. The basis of both drugs is the same substance, so there are no fundamental differences between them.

Clotrimazole or Pimafucin - which is better?

Main component — antimycotic antibiotic nitamicin . Sensitivity to the drug is predominantly mold and yeast mushrooms (including childbirth Penicillium, Candida, Cephalosporium, Aspergillus And Fusarium).

Less sensitive to Pimafucin are Pseudoallescheria boydii And dermatophytes . That is, in situations where the cause of the disease is fungi of the genus Epidermophyton, Trichophyton or Microsporum, the choice should be made in favor of the drug Clotrimazole.

The use of Clotrimazole is less often accompanied by hypersensitivity reactions. Moreover, it is less common than Pimafucin , provokes imbalances in the microflora of the genital organs.

Clotrimazole for children

There is no experience with the use of solution, ointment, gel and cream 1% in children.

Tablets are used from 12 years of age, provided the patient has menarche .

Candles are not prescribed to children.

Clotrimazole during pregnancy and lactation

Cream, gel, ointment, solution, suppositories and vag. tablets during pregnancy can be used from the 2nd trimester.

Strictly controlled studies regarding the safety of use during pregnancy; therefore, Clotrimazole is not prescribed in the 1st trimester.

Clinical studies regarding the effect of the drug on have not been carried out in women, in animal experiments adverse effects was not identified.

Clotrimazole tablets and suppositories during pregnancy (in the 2nd and 3rd trimesters) do not have a negative effect on the fetus, but using the applicator can be dangerous.

At breastfeeding the drug is used with caution, since it is unknown whether it passes into milk.

Among the first places in effectiveness in the fight against fungus is Clotrimazole. This is a broad-spectrum drug, it is used for various forms mycotic diseases. Clotrimazole: instructions for use and its effectiveness will be discussed in our article.

Release form and composition

Original international name– clotrimazole.

Available in the following types:

• vaginal tablets (suppositories) intended for insertion into intimate places (for women);
• solution, cream, spray and ointment for external use (for men and women, for children).

In the first dosage form, the content of the active substance, clotrimazole, is significantly higher than in the others (100 mg/tablet). Among the auxiliary components are lactose, magnesium, soda and tartaric acid.

The ointment contains propylene glycol, polyethylene oxide and methylparaben, and the cream contains alcohols (benzyl, cetostearyl), polysorbate and purified water. The solution additionally contains only anhydrous ethanol and isopropyl myristinate.

Clotrimazole - cream for external use

Having studied the composition of the drug, you can answer the frequently asked question: “Is Clotrimazole hormonal or not?” No, this is exclusively an antifungal agent.

Price and analogues of Clotrimazole

Cost of Clotrimazole in pharmacies:

• vaginal tablets – from 18 to 60 rubles (6 pcs.);
• solution – about 200 rubles (15 ml);
• cream - about 150 rubles (20 g), up to 350 rubles (30 g);
• ointment – ​​40 rubles (20 g).
• spray – average price 75 rub.

The price depends on the manufacturer. For example, there are domestic and English candles, which will differ in price by 20-30 rubles, even if the number of tablets in the package is the same. Are you not satisfied with the price?

Buy any of the following analogues:

• Mycotrin – 77 rubles;
• Candide – 280 rubles;
• Candid-B6 – 80 rubles.

Of course, changing the medication must be previously agreed with your doctor so as not to harm your body. This is done even when the composition is almost the same, and the active substance is the same as the main component of Clotrimazole.

pharmachologic effect

Basics pharmachologic effect– antimycotic, fungicidal, antibacterial, anti-inflammatory.

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Using Clotrimazole you can quickly cure nail fungus

Effective against fungi of Candida species, yeast, mold, dermatophytes. Poorly absorbed from the skin.

It has long been known how ointment differs from cream - the latter is based on Vaseline. Therefore, the cream is much more practical to use: it does not stain clothes and is absorbed faster.

Indications

What vaginal tablets (suppositories) help with:

• vaginal candidiasis (with thrush);
• trichomonas vaginitis.

Used as preventative measure in gynecology, before the procedure.

Solution, cream, ointment:

• dermatomycosis of smooth parts of the body and feet;
• onychomycosis;
• lichen (pityriasis versicolor, multi-colored, red);
• balanitis;
• erythrasma;
• superficial candidiasis.

It is also used for infection of mucous membranes with fungi that are sensitive to the drug.

Ointment or cream – which is better to choose? There is no exact answer to the question, because the compositions of these forms are practically the same and their indications are the same. But the composition of the ointment is more suitable for people with sensitive skin.

Instructions for use of Clotrimazole

Beforehand, to make sure that the medicine is not contraindicated for you. Carefully study the instructions for use - it is highly undesirable to deviate from the description of the use of the product.

If the medication does not help, immediately contact your doctor to clarify the diagnosis. Clotrimazole can be replaced with any other drug with a similar effect or composition. It is important to find out what exactly prevents the action, whether the previous examinations were carried out correctly.

Vaginal tablets

Lie on your back, bend your legs slightly - this is the most comfortable and safe way to insert the suppository. Make sure it goes in deep. Repeat the procedure every evening. Duration of treatment is 6-7 days. It is recommended to check the exact period with your doctor if the disease has relapsed or is in the acute stage.

Solution

Topical application 2 times a day to previously cleaned areas of localization of fungal infections and adjacent areas. Rub the product in thoroughly (a few drops of solution). The duration of therapy is up to 4 weeks, but after that it is recommended to continue treatment for some time for the purpose of prevention, reducing the dose and reducing use to 1 time.

Cream, ointment

To enhance positive effect when treating diseases of intimate places, you can apply the emulsion to the genitals: on the head or near the vagina. You must first thoroughly clean the infected areas and prepare them for use of the drug using soap with a neutral pH value.

Clotrimazole - ointment for external use 1%

The product must be rubbed in carefully and gently so as not to cause irritation. Use a thin layer of cream or ointment 2-3 times a day, depending on the severity of the disease, the form of the disease, and your state of health.

Even a child, for whom there are no restrictions on the use of Clotrimazole, can cope with how to apply the drug.

Duration of therapy:

• 4 weeks for ringworm;
• up to 3 weeks for various types lichen - pityriasis, multi-colored, red.

Treatment of fungus on feet and nails

For onychomycosis and mycosis of the feet, treatment lasts until they disappear visible signs fungus:

• the skin of the legs should become smooth, pink, without roughness or cracks, pus, or drops of blood;
• the plates must return to their original state - normal color, smooth surface, absence of any painful deformations.

The solution, cream and ointment are rubbed into the damaged areas twice a day. Using a spray for foot and nail fungus is simpler. Medicine Apply to the affected areas and allow it to dry and absorb - this process takes about 1 minute.

In case of onychomycosis, nails must be treated before the procedure (regardless of the form of the drug). Infected areas of the nail are trimmed after steaming, and the nail plate itself is disinfected cotton swab, soaked in an alcohol solution.

Before starting treatment, you should consult your doctor

The duration of treatment depends on the location of the fungus. Ringworm of the feet resolves in 4-6 weeks, depending on the severity of the disease. For full recovery onychomycosis of the feet will take 9-12 months; from onychomycosis of the hands – up to 6-7 months.

Contraindications and side effects

The main limitation of the use of the drug is the presence of individual intolerance (hypersensitivity) to the main component of the drug or the rest of the composition.

Other contraindications include:

• menstrual period, if use is due to the presence vaginal candidiasis(thrush);
• lactation.

During research, experts did not find that the use of Clotrimazole harms a woman during pregnancy. However, the remedy is recommended only in cases where the likely benefit is many times greater than possible harm to avoid negative consequences related to maternal and infant health.

When administering vaginal tablets (suppositories), pregnant women should not use the applicator.

Clotrimazole – 6 vaginal suppositories

Among the possible side effects highlight:

• painful spasms lower section gastrointestinal tract;
• the appearance of erythema;
• local allergic reactions: the appearance of blisters, itching, burning, redness of the skin and areas of application of the drug, severe swelling. Urticaria cannot be ruled out.

According to statistics, photos from patients and real reviews available below, the above effects rarely occur, so Clotrimazole can be called an absolutely effective remedy.

However, if other side effects occur that are not mentioned, consult your doctor immediately. This is probably a “signal” of the presence serious illnesses internal organs.

When carrying out procedures, it is necessary to observe some precautions: make sure that the cream, ointment or solution does not get inside. The effect is nausea followed by vomiting. The victim will also feel dizzy and have a fairly severe headache. It is recommended to immediately show the patient to specialists and provide high-quality treatment for unpleasant symptoms.

An overdose of Clotrimazole is excluded - the drug is safe even when using large portions of any dosage form.

In this article you can find instructions for use medicinal product Clotrimazole. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Clotrimazole in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Clotrimazole, if available structural analogues. Use for the treatment of thrush (candidiasis) and other fungal and genital infections in men and women, including during pregnancy and breastfeeding.

Clotrimazole- is antifungal agent broad spectrum of action for local use. Antifungal action clotrimazole (imidazole derivative) is associated with a disruption in the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes subsequent cell lysis.

Clotrimazole is active against dermatophytes, yeast-like and molds, as well as the causative agent of pityriasis versicolor (Pityriasis versicolor) and the causative agent of erythrasma. Clotrimazole has antimicrobial effect against gram-positive (staphylococci, streptococci) and gram-negative bacteria (Bacteroides spp., Gardnerella vaginalis), as well as against Trichomonas vaginalis.

Pharmacokinetics

When using clotrimazole vaginally, resorption is 3-10% of the administered dose.

Indications

• genital infections caused by yeast-like fungi the genus Candida and/or Trichomonas vaginalis (vulvovaginal candidiasis, trichomoniasis);
• genital superinfections caused by microorganisms sensitive to clotrimazole.

Release forms

Vaginal tablets 100 mg and 500 mg.

Vaginal suppositories 100 mg.

Solution for external use 1%.

Ointment for external use 1%.

Cream for external use 1%.

Gel for external use 1%.

Instructions for use and method of use

For local (vaginal) use only.

Clotrimazole vaginal tablets are administered in the evening into the vagina as deep as possible in a supine position with slightly bent legs, 1 dose daily for 6 days. vaginal tablet. A repeated course of treatment is possible after consulting a doctor.

If you have candidal vulvitis or candidal balanitis It is recommended to simultaneously prescribe clotrimazole in the form of a cream, applying it externally 2-3 times a day for 6-12 days to the affected areas.

Candles. For women and teenage girls (after the onset of sexual activity), vaginal suppositories are administered in the evening into the vagina, as deep as possible, in a supine position with slightly bent legs, 1 daily for 6 days. vaginal suppository 100 mg each. A repeated course of treatment is possible after consulting a doctor.

Cream, ointment or gel. Apply a thin layer 2-3 times a day to previously cleansed (using soap with a neutral pH value) and dry affected skin areas and rub in gently.

The duration of treatment depends on the severity of the disease, location pathological changes and effectiveness of therapy. Treatment of dermatomycosis is carried out for at least 4 weeks, pityriasis versicolor- 1-3 weeks. For fungal diseases of the skin of the legs, it is recommended to continue therapy for at least 2 weeks after the symptoms of the disease have resolved.

Solution (can be used in adults and children). A few drops of the solution are applied in a thin layer to cleansed and dry affected and surrounding areas of skin 2 (morning and evening) and rub in thoroughly. After elimination acute symptoms The disease should be treated for an average of about 4 weeks.

For tinea pedis, the drug should be used for another 2 weeks after all symptoms of the disease have resolved. It is recommended to use the solution after each foot wash.

Side effect

• increased sensitivity to the drug in the form of itching and burning sensation in the vagina.

Contraindications

• menstruation period;
• 1st trimester of pregnancy;
• hypersensitivity to clotrimazole or excipients.

Use during pregnancy and breastfeeding

In clinical and experimental studies It has not been established that the use of clotrimazole during pregnancy or breastfeeding has bad influence on the health of women or the fetus (child). However, the question of the advisability of prescribing the drug should be decided individually after consulting a doctor.

Use in children

Clotrimazole is used externally in adults and children.

special instructions

To prevent urogenital reinfection, simultaneous treatment of sexual partners is necessary (can be used in the form of a solution in men).

For trichomoniasis for more successful treatment together with clotrimazole, other drugs that have systemic action(for example, metronidazole orally).

Drug interactions

When administered vaginally, the drug clotrimazole reduces the activity of amphotericin and other polyene antibiotics.

When used simultaneously with nystatin, the activity of clotrimazole may be reduced.

Analogues of the drug Clotrimazole

Structural analogues according to active substance:

• Amyclone;
• Antifungol;
• Gine-Lotrimin;
• Imidyl;
• Yenamazole;
• Kandibene;
• Candide;
• Candizol;
• Kanesten;
• Kanizon;
• Clotrimazole-Acri;
• Lotrimin;
• Faktodin.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.