Ferretab side effects during pregnancy. Side effects of Ferretab. Contraindications and precautions

For anemia and a decrease in the number of red blood cells, doctors prescribe the medicine Ferretab. Reviews of the drug indicate that this remedy quickly and effectively eliminates all the unpleasant symptoms of anemia: weakness, fatigue, tachycardia, lethargy. This medicine is especially useful during pregnancy, when a decrease in hemoglobin is difficult to tolerate. Therefore, obstetricians-gynecologists often prescribe this remedy to their patients.

Composition and effect of the medicine

The drug is released in the form of capsules, each of which contains 4 tablets. The active components of the medicine are ferrous fumarate and B vitamin (folic acid). In addition, the medication contains excipients in the shell: titanium dioxide, magnesium stearate, lactose, cellulose and dyes. Inside the capsule there are three brown tablets with ferrous fumarate and one yellowish tablet with vitamin.

Iron and folic acid stimulate the formation of blood cells. The lack of these substances in the body causes a serious disease - iron deficiency anemia. This leads to disruption of the transport function of the blood and hypoxia of many organs. Oxygen starvation of tissues occurs.

If the body does not have enough folic acid, megaloblastic anemia may occur. In this case, the process of formation of red blood cells is disrupted.

A combination drug containing iron and folic acid helps eliminate the deficiency of these elements and normalize hemoglobin levels and the production of red blood cells.

Reviews and instructions for Ferretab indicate that this drug helps improve well-being during pregnancy. This is very important for expectant mothers, since group B vitamin deficiency negatively affects the formation of the fetal nervous system. Folic acid deficiency may result in miscarriage or premature birth.

Indications for use

According to the instructions for use and reviews of Ferretab, the capsules help with anemia with deficiency of iron and folic acid. The drug is effective in cases where anemia and vitamin deficiency are caused by malnutrition, pregnancy, bleeding or impaired absorption of iron in the body. It must be remembered that not every anemia is an indication for taking capsules. In many conditions with reduced hemoglobin, the drug should not be taken. Therefore, this remedy is not used independently. Only a specialist can identify the cause of anemia; after undergoing tests, the doctor may prescribe Ferretab. Reviews about the drug indicate undesirable effects that developed when taking the drug for other purposes.

Contraindications

In some cases, with anemia, this medicine is not recommended. There are the following contraindications to the use of capsules with iron compounds:

• anemic conditions in which the level of iron and folic acid is normal;
• anemia caused by excess iron (thalassemia, hemolytic form of anemia);
• pathologies in which the absorption of iron and folic acid is impaired.

In addition, capsules should not be taken if you are allergic to iron, vitamin B9 or any excipients included in the medication.

Undesirable effects

Reviews of Ferretab indicate that this drug is better tolerated than other iron supplements. However, the instructions for use report the following undesirable effects:

• feeling of heaviness in the stomach;
• nausea;
• vomit;
• diarrhea;
• dizziness;
• discomfort in the stomach;
• allergic rash.

In case of an overdose of the drug, symptoms of intoxication occur: severe abdominal pain, vomiting and black loose stools, in severe cases, deep loss of consciousness. It is urgent to rinse the patient’s stomach; you can also give a raw egg or milk orally, such food will neutralize iron. Then you need to call a doctor. In the hospital, symptomatic treatment will be carried out and the patient will be tested for ferritin and iron levels in the blood. If the levels of these substances exceed the norm, then poisoning is treated with the drug Deferoxamine.

How to take the medicine?

The medicine is taken on an empty stomach and should be taken with a sufficient amount of liquid. It is recommended to take 1 capsule per day. In case of severe iron deficiency or severe vitamin deficiency, you can take 2-3 capsules.

During treatment, you need to periodically take a general blood test to determine your hemoglobin level. After normalization of indicators, the medicine should be taken for another 10 days as maintenance therapy.

Interaction with other tools

The drug "Ferretab" may interact with other drugs. When taken together with vitamin C, iron absorption increases. If you use Ferretab during treatment with antacids, iron will be absorbed worse.

There are other drugs that impair the absorption of the active component of Ferretab capsules. These include tetracycline antibiotics, Carbamazepine, Sulfasalazine, Phenobarbital, Triamterene, Trimethoprim, hormonal contraceptives, prebiotics and pancreatic drugs. During therapy, alcohol intake is not recommended; ethyl alcohol is a folic acid antagonist. Some foods can also negatively affect the absorption of iron: eggs, tea, milk, bread, raw cereals. During treatment with the drug, you should avoid eating such foods and medications.

special instructions

While taking the drug, the stool may turn dark. This phenomenon should not be alarmed. Iron acts as a dye, which is responsible for the unusual color of stool. Usually this symptom disappears on its own after a few days.

During treatment, some tests may be unreliable. For example, a stool test for occult blood may give a false positive result.

Storage conditions

The drug is stored at a temperature of no more than +25 degrees. In this case, the capsules are suitable for use for 3 years. This shelf life is determined by the instructions for use of Ferretab. Price, analogues and reviews of the medicine will be discussed further.

Price and analogues

This product is inexpensive. It can be purchased in pharmacies for 280-380 rubles (pack of 30 capsules). The medicine is dispensed from pharmacies with a doctor's prescription. Self-administration of the drug is unacceptable, since during the course of therapy medical supervision and regular blood tests are required. Reviews of the price of Ferretab indicate that for most patients the drug is quite affordable.

However, patients are often interested in similar drugs. But there are no analogues for the active ingredients. You can only select medications with similar therapeutic effects. These include iron supplements. They affect hemoglobin levels in the same way as Ferretab. Instructions for use, prices and reviews of these medications indicate that they are not always cheaper, but at the same time their effect on the body is somewhat different.

Analogs of Ferretab include the following:

• "Ferlatum".
• "Biofer".
• "Maltofer."
• "Actiferrin".
• "Ferro-foil".

The drug "Ferlatum" is often prescribed to pregnant women for iron deficiency anemia. The medicine is quite effective, but more often produces side effects than Ferretab. Reviews about the analogue and price indicate that Ferlatum is quite expensive (from 600 to 1100 rubles). At the same time, this remedy causes fatigue and sometimes fainting.

The drugs "Aktiferrin", "Maltofer" and "Biofer" are low-toxic and rarely cause side effects. These medications are even prescribed to children. The cost of such medications is approximately equal to the price of Ferretab. Instructions and reviews of medications indicate that these products contain only iron, and folic acid must be taken additionally.

The medicine "Ferro-foilgamma" is a complex containing iron and multivitamins. It is often prescribed for iron deficiency anemia in pregnant women. The drug is very similar in composition to Ferretab. It also contains iron and folic acid, as well as vitamins B12 and C. The price of this product is from 250 to 300 rubles.

A drug Ferretab comp is a hematopoietic agent that replenishes iron deficiency.
The action is determined by the properties of the active substances included in its composition.
Iron fumarate is a salt of iron, a trace element necessary for the synthesis of hemoglobin. When iron is used in the form of salts, its deficiency in the body is quickly replenished, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, soreness and dry skin) and laboratory symptoms of anemia.
Folic acid is necessary for normal maturation of megaloblasts and the formation of normoblasts. It stimulates erythropoiesis, participates in the synthesis of amino acids, nucleic acids, purines and pyrimidines, and in choline metabolism. During pregnancy, it protects the body from the effects of teratogenic factors.
The drug helps maintain and restore normal levels of iron in the blood, and also prevents complications such as anemia, miscarriage, early birth and impaired mental development of the child, which can occur with a lack of iron and folic acid in the body. The amount of absorbable iron varies between 5 and 35%.
In serum, iron binds to transferrin, is involved in the formation of hemoglobin, myoglobin, cytochrome oxidase, catalase and peroxidase, or is stored in body tissues in the form of ferritin.

Pharmacokinetics

Indications for use

Mode of application

Side effects

Contraindications

Pregnancy

Interaction with other drugs

Overdose

Storage conditions

Release form

Compound

Additionally

Main settings

And used to eliminate the deficiency of these substances in the body or to prevent the occurrence of their deficiency in conditions of increased need, for example, during pregnancy, chronic blood loss, etc.

Composition, names and release forms

Currently, Ferretab is available in a single dosage form - this extended-release capsules for oral administration. Capsules are often called tablets in everyday life, which is incorrect. By the word “tablets” people mean the form for oral administration, and since Ferretab is available in capsules, in this case we can assume that capsules = tablets.

Ferretab capsules contain the following substances as active ingredients:

• Iron fumarate (II) in the amount of 163.56 mg, which is equivalent to 50 mg of pure iron;
• Folic acid in the amount of 540 mcg, which is equivalent to 500 mcg of pure substance.

• Azorubine dye;
• Colloidal silicon dioxide;
• Titanium dioxide;
• Gelatin;
• Microcrystalline cellulose;
• Lactose monohydrate;
• Polyacrylate;
• Magnesium stearate;
• Quinoline yellow dye.

Photo

Action

The antianemic effect is provided by both ferrous fumarate and folic acid, which are part of the drug. Thus, ferrous fumarate is a source of iron ions, which are necessary for the synthesis of hemoglobin. That is, Ferretab ensures that the body receives a sufficient amount of iron, from which hemoglobin is synthesized, which will eliminate and prevent the development of anemia. Folic acid is necessary for the process of formation of normal red blood cells, therefore its entry into the body promotes the absorption of iron and proper hematopoiesis in the bone marrow.

In addition, folic acid is necessary for normal growth and development of the fetus, especially its brain, so all pregnant women are recommended to take this vitamin from the planning stage of pregnancy until at least the 12th week of gestation.

Thus, Ferretab is a source of two substances important for hematopoiesis and normal fetal development, as a result of which the drug is very often used during pregnancy.

Indications for use

In addition, Ferretab capsules are indicated for use in the treatment and prevention of iron deficiency in conditions where the need for this element is higher than the amounts entering the body, for example:

• Pregnancy period;
• Breastfeeding period;
• Impaired absorption of iron in the digestive tract due to various gastrointestinal diseases (for example, colitis, gastric ulcer, etc.);
• Prolonged bleeding (for example, from the stomach, from hemorrhoids, from the bladder, uterine bleeding, etc.);
• Excessive blood loss;
• Heavy menstruation in women;
• Poor nutrition;
• Chronic alcoholism;
• Long-term or severe infectious diseases;
• Taking anticonvulsants and oral contraceptives.

Ferretab - instructions for use

General provisions

Ferretab can be taken by adults and adolescents from 12 years of age in the same dosages. It is not recommended to give the drug to younger children.

Ferretab for the treatment of anemia, including during pregnancy, you should take one capsule once a day. In case of severe anemia (hemoglobin level below 80 mg/l), the dose is increased to 2 - 3 capsules per day, which are taken one piece 2 - 3 times a day. Taking the drug in the required dosage is continued until the hemoglobin level normalizes, on average 8–12 weeks. Then, for another 4 weeks after normalization of hemoglobin concentration, Ferretab is taken in a maintenance dose of one capsule per day to create an iron reserve in the body.

For preventive purposes(including during pregnancy and breastfeeding) Ferretab is always taken one capsule per day as long as the risk of anemia and iron and folic acid deficiency remain.

Black tea, coffee, milk and dairy products, solid foods, bread, raw cereals and eggs impair iron absorption, so Ferretab is optimally taken on an empty stomach 30 to 60 minutes before meals. However, if the drug is taken after meals due to irritation of the gastric mucosa, then the menu should be designed in such a way that the listed products are not consumed before taking Ferretab.

During the period of taking Ferretab, the stool may turn black, which is normal and does not require discontinuation of the drug or any special treatment.

While taking Ferretab, the benzidine test may be false positive.

Impact on the ability to operate machinery

Overdose

• Nausea;
• Vomit;
• Diarrhea with dark-colored feces;
• Drowsiness;
• Paleness of the skin and mucous membranes;
• Shock to the point of coma.

After carrying out these emergency measures, the level of serum iron and ferritin in the blood should be measured, and if their concentrations are significantly higher than normal, Desferal should be taken. Subsequently, if necessary, symptomatic therapy is carried out aimed at maintaining the normal functioning of vital organs and systems.

Interaction with other drugs

Antibiotics of the tetracycline group (Tetracycline, Doxycycline, etc.) interfere with the absorption of iron, reducing the effectiveness of Ferretab.

Ascorbic acid enhances the absorption of iron, as a result of which its use increases the effectiveness of Ferretab.

Ferretab during pregnancy

Since folic acid must be taken in the first trimester, Ferretab is recommended for women to drink from the beginning of pregnancy until the 12th week of gestation. After this, if the risk of developing anemia remains, you can continue taking the drug in a prophylactic dosage of one capsule per day, until childbirth or for 2 to 3 months. If the risk of developing anemia is low, you can stop taking Ferretab and start taking it again only after your hemoglobin level drops below normal.

Pregnant women for the prevention of anemia It is recommended to take Ferretab one capsule once a day for a long period of time. If the risk of anemia is very high, Ferretab can be taken continuously throughout pregnancy. If the risk of anemia is low, then Ferretab is not taken continuously until childbirth, but in courses lasting 8–12 weeks, with intervals between them of 4–6 weeks.

For the treatment of already developed anemia Pregnant women are recommended to take Ferretab one capsule 2 - 3 times a day for 8 - 12 weeks. After this, it is necessary to continue taking the drug in a maintenance dosage of one capsule per day for another 4 weeks. Then they take a break for 4 weeks, after which they resume taking Ferretab one capsule per day for 8 weeks to prevent the re-development of anemia. Such 8-week preventive courses of administration with 4-week intervals between them are continued until childbirth.

To ensure adequate folic acid intake early in pregnancy, women are recommended to take Ferretab from the moment of conception until the 12th week of gestation without interruption, one capsule per day. Starting from the 13th week, Ferretab can be stopped or, on the contrary, continued for the purpose of preventing anemia.

Ferretab for children

• Individual hypersensitivity or allergic reactions to any components of the drug;
• Diseases associated with the accumulation of iron in the body (for example, hemochromatosis, hemosiderosis);
• Impaired absorption of iron (siderochristic anemia, lead anemia, pernicious anemia);
• Anemia not caused by iron or folic acid deficiency (aplastic anemia, hemolytic anemia, thalassemia);
• Age under 12 years.

Ferretab - analogues

In addition, Ferretab has analogs for therapeutic action, which include drugs containing iron II and III compounds. The closest analogues in terms of the nature of their action are preparations containing iron II compounds. And analogues containing iron III are relatively more distant.

So, analogues of Ferretab containing iron II compounds are the following drugs:

• Actiferrin compositum capsules;
• Hemofer drops for oral administration;
• Hemofer Prolongatum tablets;
• Sorbifer Durules tablets;
• Tardiferon tablets;
• Fenyuls capsules and Fenyuls 100 tablets;
• Ferrogradumet tablets;
• Ferroplex dragee.

• Argeferr solution for intravenous administration;
• Biofer chewable tablets;
• Venofer solution for intravenous administration;
• Dextrafer solution for injection;
• CosmoFer solution for injection;
• Likferr100 solution for intravenous administration;
• Maltofer syrup, tablets, drops, solution;
• Monofer solution for intravenous administration;
• Totema solution for oral administration;
• Ferlatum and Ferlatum Fol solution for oral administration;
• Ferrum Lek syrup, tablets, solution for intramuscular injection;
• Ferinject solution for intravenous administration;
• FerMed solution for intravenous administration;
• Fenyuls Complex drops and syrup;
• Ferry syrup.

It is very rare in our time that pregnancy proceeds without anomalies, pathologies, etc. After all, the process of gestation is influenced by the environment and a woman’s chronic diseases. If she is observed by a competent doctor, then proper treatment and implementation of his recommendations will be the key to a successful solution to all emerging problems. One of them, anemia, can be treated with Ferretab. Let's try to figure out how the medicine is connected with this disease when carrying a baby.

To whom is the drug prescribed and why?

Ferretab is available in extended-release capsules. They consist of two main components: folic acid and iron fumarate. Among the excipients are silicon and magnesium. Ferretab belongs to the pharmacological group of combined antianemic drugs.

Iron fumarate is an iron salt. This trace element is necessary for the synthesis of hemoglobin. When iron is used in the form of salts, its deficiency in the body is eliminated very quickly. The result of such replenishment is regression (decrease) of the symptoms of anemia, namely weakness, fatigue, dizziness, etc.

Folic acid is needed by the body for the maturation of megaloblasts and the formation of normoblasts. It promotes the synthesis of amino acids and other substances. Protects pregnant women from neurological pathologies in the development of the unborn child.

As for the excretion of Ferretab, iron leaves the body with feces, urine, and sweat, and folic acid leaves the body through the kidneys and intestines.

Usually the drug is prescribed to take 1 capsule per day. When anemia is severe, doses can be increased to 2-3 capsules until the condition normalizes. As a rule, Ferretab is well tolerated and side effects are rarely observed when taking it. Important: the drug should be stored in a place protected from light at a temperature of 25°C.

Prescription of Ferratab for pregnant women

One of the most common abnormalities during pregnancy is low blood hemoglobin. According to medical statistics, anemia (anemia) occurs in 85-95% of expectant mothers. This disease is usually detected by taking a general blood test. It will show your hemoglobin level and red blood cell count.

The state of iron deficiency directly affects the unborn child, because insufficient iron concentration can cause pathology in the development of the fetus and, in the worst case, its death. Therefore, it is important to maintain the required level of hemoglobin in the blood of a pregnant woman. Iron promotes the delivery of oxygen to all tissues and systems of the body. Oxygen starvation (hypoxia) can result in fatigue and dizziness. Sometimes anemia has specific manifestations in a pregnant woman. This is the first time in my life that I have a desire to eat chalk, to breathe in the smell of paint and gasoline. If the degree of anemia is mild, the pregnant woman may not experience any of the above symptoms.

Ferretab is prescribed to pregnant women in order to normalize the hemoglobin level in the blood. The dose and regimen of the drug during pregnancy are prescribed only by the supervising physician. Based on the pregnant woman’s test data, he prescribes the patient the optimal course of treatment. Its duration depends on the onset of normalization of the condition. Perhaps after this the doctor will prescribe a supportive, that is, preventive course. In particular, this applies to pregnant women belonging to the risk group.

It should be noted that diet is also an aid in the treatment of anemia in pregnant women. A woman should know that meat (liver, heart), eggs, and fish are rich in iron. From the diet of animal origin, iron is absorbed into the blood at a level of 20-30%, and from plant origin - no more than 5%. Iron is found in peaches, pomegranates, tomatoes, and beets.

Be healthy!

Especially for Elena TOLOCHIK

From Guest

Ferretab didn’t help me either, my hemoglobin became lower (They prescribed Gyno-tardiferon.... I’ll try

From Guest

Throughout the pregnancy, hemoglobin was low, never rose above 110, Maltoffer only helped for the first time, and it also affected digestion. Ferritab has no effect on stool, I absolutely agree with this, in terms of level - so far I have raised it from 98 to 104 (I take 1 tablet for two weeks), I wash it down with vitamin C.

From Guest

When I was preparing for pregnancy, I took Ferretab comp. (on the advice of my colleague and especially since she and I coincided that she and I have blood type II). Moreover, my colleague was recommended by a gynecologist during pregnancy. In short, this drug helped her and me. As for me, after giving birth my hemoglobin was up to 100, and 1 month. After drinking the drug it rose to 141 and there was no constipation.

Active ingredient: 1 capsule contains 3 mini-tablets of iron fumarate and 1 mini-tablet of folic acid with the following composition:

3 mini iron fumarate tablets contain:

Active ingredient: iron fumarate 152.1 mg (corresponds to 50 mg of iron II);

Excipients: lactose, polyacrylate dispersion 30%, colloidal silicon dioxide, magnesium stearate

1 mini folic acid tablet contains

Active ingredient: folic acid 0.5 mg

Excipients: lactose, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate

Composition of hard gelatin capsule: azorubine (E 122), yellow quinoline (E 104), titanium dioxide (E 171), gelatin.

Dosage form

Pharmacological group

Antianemic drugs. Complex preparations containing iron and folic acid.

Indications

Treatment of anemia caused by a lack of iron and folic acid, including in women during pregnancy.

Contraindications

Hypersensitivity to the active substances or to one of the excipients. Diseases accompanied by the accumulation of iron in the body (hemochromatosis, hemosiderosis, chronic hemolysis), impaired absorption of iron (sideroachrestic anemia, thalassemia, anemia due to lead poisoning) hemoglobinopathy, hemolytic anemia, aplastic anemia, pernicious anemia, anemia not associated with a lack of iron and folic acid disorders of the gastrointestinal tract (intestinal obstruction, intestinal diverticula, inflammatory bowel diseases, stenosis of the esophagus and / or other obstructive diseases of the digestive tract, peptic ulcer of the stomach and duodenum in the acute stage); regular blood transfusions; simultaneous use of iron preparations parenterally.

Directions for use and doses

Take capsules on an empty stomach, without chewing, with plenty of liquid.

1 capsule per day. In case of severe deficiency of iron and folic acid, increase the dose to 1 capsule 2-3 times a day.

Take the drug for 8-12 weeks. After restoration of serum iron levels and normalization of hemoglobin levels, the drug should be taken for another 4 weeks until the optimal therapeutic effect is achieved.

Adverse reactions

From the blood: treatment with products containing iron can provoke the appearance of paroxysmal nocturnal hemoglobinuria, erythropoietic porphyria or cutaneous porphyria tarda.

From the digestive tract: feeling of fullness in the stomach, nausea, vomiting, diarrhea, constipation, flatulence, black stool, epigastric pain; Due to the use of excessively high doses, hemorrhagic gastroenteritis may occur.

Other. Skin rash, hives, redness of the skin, itching.

Long-term unjustified use can lead to hemosiderosis.

Overdose

Symptoms Acute iron overdose can cause nausea and vomiting, and in severe cases, collapse and death. The lethal dose of elemental iron is considered to be 180-300 mg/kg body weight. However, for some patients, a dose of elemental iron of 30 mg/kg may be toxic. Use of the drug in excessively high doses can lead to iron intoxication with the following symptoms:

1-6 hours after administration - stomach pain, vomiting, black stool, diarrhea, gastrointestinal bleeding, shock, coma

6-24 hours after administration - fever, leukocytosis, metabolic acidosis, coagulopathy, liver and kidney damage.

Treatment. In case of overdose, measures must be taken to stop the absorption of even more iron:

• before hospitalization, you must drink milk and take raw eggs,
• special therapy for intoxication: deferoxamine 2-10 g orally or 1-2 g parenterally (in 200 ml of glucose solution);
• if the patient’s condition allows, induce vomiting or rinse the stomach;
• use laxatives;
• further symptomatic treatment of shock.

Specific therapy. Vomit should be checked for the presence of capsules. If a sufficient number of capsules are not removed, it is necessary to perform gastric lavage with 0.9% sodium chloride solution or 1% aqueous sodium carbonate solution. It is necessary to conduct a fluoroscopic examination of the abdominal cavity to determine the number of capsules remaining. If capsule removal methods do not produce the desired results, surgery may be required. The best method for assessing the severity of the condition is to determine the iron content in the blood serum and the serum perfusion capacity (SEAC) of the blood. If the serum iron level is higher than the ZES level, there is a possibility of systemic poisoning. Deferoxamine chelation therapy should be carried out if:

• a potentially lethal dose was taken (180-300 mg/kg or more);
• serum iron concentrations above 400-500 mg/dL;
• the concentration of iron in the blood serum exceeds the EZZS and / or if patients have severe symptoms of iron intoxication: coma, shock.

Use during pregnancy or breastfeeding

The drug can be used during pregnancy and lactation as prescribed by a doctor.

Children

The use of the drug in children is contraindicated due to the lack of clinical experience.

Features of application

In most cases, treatment of iron deficiency anemia leads to positive results. However, it is extremely important to find out the cause of iron deficiency anemia.

The ineffectiveness of therapy may be due to circulatory insufficiency, chronic alcoholism, and polyhypovitaminosis. Before starting treatment, it is necessary to exclude the possibility of pernicious anemia.

Eggs and milk, black tea, coffee, bread, raw cereals, and dairy products inhibit iron absorption. Oral preparations containing iron should not be taken within 1-2 hours of consuming the above-mentioned foods.

The drug may change the color of stool to black, which may interfere with the diagnosis of chronic bleeding in the digestive tract. The fecal occult blood test sometimes gives false positive results.

The use of folic acid (1 mg or higher) in a state of pernicious anemia may lead to false remission of hematological parameters during disease progression. Therefore, pernicious anemia should be ruled out before starting folic acid use.

The drug contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.

The dye azorubine (E 122), contained in capsules, can cause allergic reactions.

The ability to influence the reaction rate when driving vehicles or other mechanisms

Unknown.

Interaction with other drugs and other types of interactions.

With simultaneous use of Ferretab comp. With the following drugs, their effectiveness may vary.

Iron salts reduce the absorption of concomitantly taken drugs, such as DNA hydrase inhibitors (for example, ciprofloxacin, levofloxacin, norfloxacin, ofloxacin), diphosphonates, levodopa, carbidopa and methyldopa, penicillin, sulfasalazine. Iron salts reduce the absorption of thyroxine. Iron absorption is reduced when calcium and magnesium supplements are taken simultaneously. Citric acid promotes iron absorption. Simultaneous intake of iron salts with non-steroidal anti-inflammatory drugs can increase the irritating effect of iron on the mucous membrane of the digestive tract. GCS can enhance the stimulation of erythropoiesis. Concomitant use of vitamin E may reduce the pharmacological effect of iron in the body. The simultaneous use of iron salts and allopurinol should be avoided.

The absorption of folic acid is reduced when taken simultaneously with analgesics, anticonvulsants, antacids, cholestyramine, sulfonamides, antibiotics, cytostatics (methotrexate), trimethoprim, triamterene. When used simultaneously with chloramphenicol, neomycin, polymyxins, tetracyclines, the absorption of folic acid decreases. With simultaneous use, folic acid reduces the effects of primidone, PAS, sulfasalazine, hormonal contraceptives for oral administration, chloramphenicol, phenytoin, increasing their metabolism.