Headache, pain in the arms and joints, thickening of the hands and feet and other symptoms of acromegaly. Prognosis and prevention of acromegaly. Bactericidal effect is provided

Changes in facial features can be not only congenital, but also acquired.

Acromegaly - symptoms and signs

Acromegaly is a disease in which individual parts of the body (arms, legs, head, nose, ears, etc.) enlarge due to damage to parts of the central nervous system (pituitary tumor) responsible for the production of growth hormone. Excess of this hormone (growth hormone) leads to disproportionate growth internal organs, soft tissues and skeletal bones.

Symptoms of acromegaly

At the age of 20-40 years, changes in appearance begin to slowly occur, which relatives and friends first begin to notice. Changes in facial features appear: increase lower jaw, cheekbone, brow ridges, spaces between teeth, ears, lips, nose. The formation of voluminous, rough folds occurs on the face, in the cheeks, forehead, and back of the head. Then the patients themselves begin to complain of symptoms such as sleep disturbances, weakness, sweating, headaches, joint pain, and numbness of the limbs. In women, the menstrual cycle is disrupted and reproductive function. In men with symptoms of acromegaly, the sexual desire and potency.

Signs of acromegaly

The feet and hands increase in width and thicken calcaneus. There is an increase in sweat and sebaceous glands, the appearance of acne (acne), increased hair growth. People who have signs of acromegaly do not tolerate heat well and sweat profusely even at room temperature. The vocal folds thicken, the voice becomes deeper, and the habit of snoring in sleep appears. If bone growth is not yet complete, the patient develops gigantism.

An increase in muscle mass with acromegaly initially leads to an increase in muscle strength, and then to muscle weakness and a decrease in motor activity. There are complaints of symptoms such as muscle pain, a feeling of “pins and needles” at night. At the same time, other endocrine disorders: diabetes mellitus, diseases thyroid gland, decreased function of the gonads, etc.

Paget's disease

Symptoms of Paget's disease

Characteristic changes in the skull in Paget's disease. This disease is characterized by the following symptoms: changes in bone tissue, as a result of which the bones increase in size while simultaneously weakening them. The cause is believed to be a viral infection. Bones with Paget's disease become weak, brittle and brittle, change shape, which causes pain. Paget's disease is often malignant. Most often the spine, pelvic bones, lower extremities, and skull are affected. Unlike acromegaly, with Paget's disease the head is enlarged not due to soft tissue, but as a result of enlargement of the skull bones.

At the same time, they become uneven, loose, the cranial vault is thickened, the shape of the skull is lumpy and knobby. If the auditory nerve is involved in the process, then deafness may develop. Damage to the bones of the facial skull leads to changes in the shape of the face, reminiscent of a lion's head (“leontiasis”). The bones of the limbs (lower leg and forearm) soften and bend in an arched manner with a convexity forward, the skin over the lesion is hot. Patients are concerned about the following symptoms: severe pain and limited movement in the joints of the affected bones.

All-Russian Olympiad for schoolchildren in biology 2015

for 10th grade

Full name of the student__________________________________________________________

School________________________________________________________________

Teacher_______________________________________________________________

Exercise 1. The task includes 36 questions, each of them has 4 possible answers. For each question, you must select only one answer, which is the most complete and correct. The index of the selected answer must be entered into the answer matrix. For each correct answer, the Olympiad participant receives 1 point.

1. Plants differ from animals, first of all:

A) cellular structure body; b) way of eating; c) differences in chemical composition cells; d) the presence of vacuoles.

2. K higher plants relate:

a) purple algae; b) multicellular green algae; c) mosses; d) cyanides.

3. Mushrooms are classified into a separate kingdom because:

a) they are immobile, but capable of photosynthesis; b) their cells contain chitin, and their body consists of mycelium; c) reproduce by spores and have no organs; d) have no organs, heterotrophs.

Which of the named mushrooms belongs to the lamellar mushrooms?

a) boletus; b) oiler; c) saffron milk cap; d) boletus.

5. Mushrooms are similar to some plants:

a) reproduction by spores; b) autotrophic method of nutrition; c) heterotrophic mode of nutrition; d) absence of a cell wall.

6. Viruses have such signs of living things as:

a) food; b) growth; c) metabolism; d) heredity.

7. Viruses are classified as precellular organisms because they:

8. Cartilaginous fish are different from bony fish:

a) lack of scales; b) absence of a swim bladder; c) the presence of gill covers; d) two-chamber heart.

9. Branch of zoology that studies animal behavior:

a) morphology; b) ethology; c) herpetology; d) arachnology.

10. The fruiting bodies of cap mushrooms are used for:

a) formation of disputes; b) vegetative propagation; d) savings nutrients;

e) experiencing unfavorable conditions.

11 . Among reptiles, the eardrum is absent in:

a) crocodiles; b) turtles; c) snakes; d) lizards.

12. The central nervous system of chordates has the form:

a) stairs; b) strings; c) tourniquet; d) tubes.

13. Dioecious:

a) white planaria; b) liver fluke; c) bovine tapeworm; d) human roundworm.

14. There is no intermediate host in:

a) liver fluke; b) bovine tapeworm; V) pork tapeworm; d) human roundworm.

What type of bones are vertebrae?

a) spongy long; b) spongy short; c) flat; d) tubular short.

The taste zone is located in... the lobe of the cerebral hemispheres.

a) temporal; b) occipital; c) frontal; d) parietal.

Which skin cells are not capable of dividing?

a) cells skin glands; b) cells of the upper layer of the epidermis;

c) cells of the hair follicle; d) cells of the deep layer of the epidermis.

18. The placenta does not provide:

a) removal of metabolic products; b) oxygen supply; c) supply of nutrients; d) synthesis of hormones and antibodies.

19. The main humoral regulator of respiration is:

a) adrenaline; b) oxygen; c) norepinephrine; d) carbon dioxide.

20. The patient has an enlarged nose, lips, tongue, hands, and feet; the voice is rough because vocal cords thickened. What diagnosis will the endocrinologist make?

a) acromegaly; b) Graves' disease; c) bronze disease; d) gigantism.

21. Lancelet belongs to the systematic group:
a) invertebrates; b) gillless; c) skullless; d) legless.

22. Intraspecific competition is:

a) abiotic factor; b) biotic factor; c) anthropogenic factor; d) psychological factor.

23. Cells or cellular structures can be divided according to their density using the method:

24. Bactericidal effect provide:

a) ultraviolet rays; b) visible light rays; c) infrared rays; d) electromagnetic radio waves.

25. The presence of centrioles and the absence of a cell wall is characteristic of cells:

a) mushrooms; b) bacteria; c) plants; d) animals.

a) dodder - clover; b) ant - aphid; c) aspen - boletus; d) mongoose - rat.

27. Which cell organelles do not have membranes:

a) mitochondria; c) lysosomes; b) ribosomes; d) plastids.

Numb lips are an unpleasant symptom that indicates neurological problems. Let's consider its features, causes of occurrence, methods of diagnosis and treatment.

Partial or total loss sensitivity may be caused various factors. Paresthesia appears due to external irritation, problems in the body, deficiency of any substances, or side effects from a recent illness. In any case, this is a symptom that requires attention, especially if it appears systematically.

Most often, a defect occurs as a response to damage nerve root or nerve ending in the brain or spinal cord. In this case, the disorder appears in the area along which the impulse from the damaged fiber travels.

ICD-10 code

R20 Skin sensitivity disorder

Epidemiology

Impaired conduction of sensory nerve endings in the peripheral or central nervous system causes paresthesia. Epidemiology, that is, the prevalence of this disorder is associated with age factors and predisposition to certain pathologies. People suffering from neurological diseases, frequent stress, dental problems or pathologies endocrine system, much more often they complain of loss of sensation in the lips or other parts of the body.

During numbness, the patient feels touch or pressure, but there is no temperature or pain sensitivity. This causes poor circulation and further irritation of the nerve. If the disorder persists for long period time in the same area of the body, this can lead to complete death nerve fibers, therefore requiring mandatory medical care.

Causes of numb lips

Numb lips occur due to many reasons. These can be serious diseases of the body, neurological reactions, or the body's response to any irritant. Let's take a closer look at the most common reasons loss of sensitivity:

Unpleasant sensations occur due to prolonged muscle tension, spinal misalignment or compression spinal cord. This leads to poor circulation, anemia and nutritional deficiencies. The disease can cause a stroke. In addition to swollen lips, frequent headaches, increased fatigue, loss of sensation in the limbs, and pain when moving the neck appear.

Provokes nervous system disorders. A nervous state is accompanied by memory impairment, decreased concentration, sleep disturbances, hair loss and brittle nails. For treatment, it is recommended to eat nuts, sour milk, mushrooms and fish, as they are rich in vitamin B and will help get rid of paresthesia.

Neuritis of the facial nerve occurs due to disruption of impulses between the brain and facial muscles. The disorder is accompanied by pain behind the ears, the inability to close the eyelids, facial asymmetry and numbness of the eyebrows. In advanced cases, it leads to paralysis of the facial nerve.

With this endocrine disease, sensitivity decreases different parts bodies. The patient complains about increased fatigue, frequent urge to the toilet, endless hunger and thirst, sudden weight loss, deterioration of visual acuity and prolonged wound healing. To prevent the disease and diagnose it in the early stages, it is necessary to check the level of glucose in the blood.

Application medical supplies, various cosmetics or food products can cause numbness of the lips. In most cases, allergies manifest as a complex of symptoms: itching, runny nose, sneezing, rash.

Chronic fatigue and stress cause disorders of the nervous system. Against this background, throbbing pain, dizziness, attacks of nausea and vomiting, fear of noise and bright light appear. For treatment, it is necessary to add potassium, magnesium, calcium to the diet and, of course, reduce the stress that depletes the body.

Dental diseases

Inflammation of the gums or toothache can provoke this symptom. In this case, unpleasant symptoms are temporary. To solve the problem you need to contact your dentist.

Hypertension or hypotension

Fluctuations in blood pressure negatively affect general health, causing paresthesia of different parts of the body, headaches and dizziness. To alleviate the condition, it is recommended to consult a doctor, and in case of acute symptoms, call an ambulance.

Loss of sensation in the face is the first sign of the disease. Later appears heat, various blistering rashes on the body, itching, burning, joint pain and enlarged lymph nodes.

Numbness is the first symptom of the disease, which is accompanied by impaired coordination of movement, deterioration of visual acuity, muscle weakness. This is due to the fact that the cells of the body attack the cells of the nervous system.

Infections

Many viral infections cause inflammation of the nerves. Very often, after suffering from meningitis, otitis media or herpes, signs of numbness in the lips and other parts of the body appear. In addition, the patient may complain of painful sensations in the area of the affected nerve, pain in the eyes, lacrimation and runny nose.

These are some of the most common causes of an unpleasant symptom. In order to determine what actually caused it, you need to consult a neurologist. The sooner the root cause of the problem is identified, the easier and faster it can be eliminated.

Pathogenesis

Loss of sensation in the lips occurs due to disruption of nerve impulses. Pathogenesis can be associated with both exogenous (mechanical, psychogenic) and endogenous (circulatory disorders, endocrine diseases, oncology) factors. There are three mechanisms in its development:

Receptor - the degree of excitation of receptors completely depends on the duration of action of the stimulus and the density of their distribution. Numbness is a reaction of adaptation to the stimulus.
Conductive – represents a lesion different levels somatosensory perception, spinal cord, peripheral nerves and dorsal roots. Leads to loss of sensitivity of all types.
Central – damage to the structures of the cerebral cortex and thalamus. It manifests itself as a decrease or complete disappearance of sensitivity and can provoke thalamic pain.

Depending on the origin of the pathological symptom and the factors that provoked it, the examination and treatment plan depends.

Symptoms of numb lips

The main sign of paresthesia of any part of the body is a slight tingling sensation due to irritated nerve endings. Symptoms of lip numbness are characterized by complete or partial loss of sensation. This may last for a few minutes or a longer period of time. If the disorder occurs frequently, then trophic changes are observed in the area of pathology, indicating serious damage to the nerve fibers.

Unpleasant condition occurs due to irritation or damage to the systems responsible for the transmission of nerve impulses: spinal cord, peripheral nerves, thalamus, parietal lobes of the brain. Let's take a closer look at the symptoms of numbness under the influence of various factors:

When the spine is damaged, that is, a malfunction of the vertebrae, seemingly unrelated symptoms appear: numbness, headaches, high blood pressure, a burning sensation in the back of the head, neck and between the shoulder blades, impaired coordination of movements, problems with hearing and vision.
In the case of oncological lesions of the brain, facial paresthesia is accompanied by apraxia, agraphia, hemianopsia and other pathological conditions.
With a stroke, there is swelling and drooping of one side of the mouth. It occurs on the side opposite to the lesion. A similar thing is observed with traumatic brain injuries.
If the unpleasant condition is associated with Guillain-Barré syndrome, then muscle weakness, numbness of the lower extremities and facial nerves. Such symptoms may also indicate an upcoming migraine attack.
In herpes zoster, loss of sensation is accompanied by dermatomes, various erythematous vesicles, severe itching, burning and painful sensations.
If discomfort is accompanied by sudden paralysis or paresis of any part of the body for a long period of time, then this indicates an ischemic circulatory disorder. With other cardiovascular diseases, there is a feeling of coldness in the extremities and tingling.

If the disorder is accompanied by a feeling of tingling and coldness, then this may indicate heavy metal poisoning. Sometimes loss of sensitivity occurs during pregnancy due to toxicosis or due to an animal bite, that is, when the prodromal stage of rabies is suspected.

First signs

Subjective sensations of tingling, crawling and slight burning are the first signs of numbness. Normally, this occurs when any part of the body is in a compressed state for a long time. For example, biting your lip during a stressful situation can cause short-term loss sensitivity. As soon as the blood supply is restored, the discomfort goes away.

At pathological reasons paresthesia, it is accompanied by additional symptoms. This may include headaches, dizziness, tingling in other parts of the body (most often the limbs), increased or decreased blood pressure, and more. Such symptoms require attention, so when they appear, it is recommended to consult a neurologist and undergo diagnostics to determine the true cause of the discomfort.

Numbness of the lower lip

There are many reasons that cause loss of sensation in certain areas of the body. Numbness lower lip may be due to the following factors:

Poor circulation in the brain stem.
Inflammatory processes in oral cavity(damage to the dental nerve, gums).
Nuclear neuropathy trigeminal nerve.
Osteochondrosis (compression of the vertebral artery).

Discomfort may occur during anesthesia for dental treatment or after implantation. If the numbness does not go away 24 hours after the procedure, you should consult your doctor. Loss of sensation in the lower lip may be due to poor circulation. This happens during a long kiss.

If the pathological condition occurs too often and is accompanied by additional painful symptoms, then you should consult a doctor for diagnosis and adequate therapy.

Numbness of the upper lip

Oral health problems are the main cause of upper lip numbness. Most often, paresthesia accompanies the following conditions: gumboil, diseased teeth, gum inflammation, abscess. Anesthesia after a dental procedure also causes temporary loss of sensation.

If the symptom is accompanied by numbness of the nose, then this indicates trigeminal neuralgia. In some cases, eating cold or too hot food provokes a defect. Unpleasant sensations can be complemented by a sensation of crawling and tingling of the skin of the face.

Another cause of the disorder is cosmetic permanent lip makeup. In this case, women often complain about sensitivity problems. An incorrectly performed tattoo procedure or improper care after it provokes not only discomfort, but also swelling.

Numbness of lips and hands

Loss of sensation in the limbs combined with numbness in part of the face indicates serious neurological problems. Numbness of the lips and hands often occurs before a stroke or ischemic attacks. Unpleasant sensations are combined with impaired coordination of movements, depression of consciousness, paralysis of half the face, slurred speech. These symptoms require emergency medical attention, as they can cause irreparable harm to the body.

If the symptom appears at night along with headaches, discomfort in the neck and back, then this may be a herniated disc or osteochondrosis cervical region spine.
Lip swelling and thumbs hands may be associated with neurofibroma or hemangioma. They compress nerve endings, causing muscle atrophy.
Another one possible reason violations are severe intoxication or chronic alcoholism.
If parts of the face and left arm become numb, the development of atherosclerosis or cardiovascular pathologies can be suspected.

If, after a comprehensive diagnosis, no organic causes of the pathology are identified, then it is associated with vegetative-vascular dystonia. The disease is a series of symptoms indicating mental disorders. An unpleasant condition is treated by a psychotherapist or neurologist.

Numbness of lips and tongue

One of the reasons for decreased tactile sensitivity is numbness of the lips and tongue. An unpleasant condition occurs in cases such as:

Allergic reaction.
Inflammatory lesions of the facial nerves.
Pathological diseases of the brain.
Oncology.
Circulatory disorders (osteochondrosis, diseases of cardio-vascular system, mechanical injuries).
Dental problems.

If the tip of the tongue and lips become numb, this indicates hypoglycemic syndrome. The disease is characterized by a decrease in blood sugar levels, a feeling of hunger, increased sweating, headaches and muscle pain, frequent change mood, irritability, tremors of limbs, surges in blood pressure. In order to prevent loss of consciousness and relieve an unpleasant symptom complex, you need to eat a couple of pieces of sugar. This will improve your well-being and relieve numbness.

Numbness of the lip and chin

Many dental diseases and procedures to treat them cause temporary numbness in the lip and chin. That is, in this case, paresthesia is associated with an acute inflammatory process or the effect of an anesthetic drug - anesthesia. Sometimes, after treatment, symptoms persist for six months. This is not dangerous and is associated with the previous therapy.

Discomfort occurs with injuries to the cervical spine or maxillofacial injuries. So, after a fracture of the lower jaw, numbness persists for 3-4 months. Unsuccessful plastic or cosmetic procedures are another cause of sensitivity disorders. When installing a chin implant or lip augmentation, discomfort may occur.

Numbness of lips and nose

With paresthesia of the nose, patients complain of numbness of its wings and tip, which gradually turns to upper lip and even the chin. Discomfort occurs with various colds, injuries, cardiovascular defects and other pathological conditions. Sometimes numbness occurs during sleep or long stay in a squeezing position. In this case, the discomfort is associated with poor circulation.

Let's look at the common causes of numbness in the lips and nose:

Vegetative-vascular dystonia – pathological condition is a complex of symptoms neurological origin, which periodically worsen. To alleviate them, you need to contact a neurologist and undergo a series of examinations.
Osteochondrosis - tingling or burning in the nose and lips is accompanied by severe headaches, dizziness and muscle weakness. If you have these symptoms, you should immediately consult a doctor and undergo an MRI and CT scan.
Trigeminal neuritis is an inflammatory lesion of the nerve endings that provide sensitivity. IN pathological process part of the nerve is involved, this manifests itself as leakage of the nasolabial triangle, lips and tip of the nose.
Allergic reactions - hypersensitivity to any substances or allergies to cold, can cause attacks of numbness.

In addition to the reasons described above, the defect appears during a stroke. The patient complains of severe pain in the back of the head, decreased visual acuity, elevated temperature. Against this background, facial expressions are distorted. Such symptoms require urgent medical attention.

Numbness of the lip after surgery

Surgical intervention is one of the causes of impaired tissue sensitivity. An alarming symptom should be that after the procedure and the time specified by the doctor, the numbness from the anesthetics has not gone away. In this case, we can talk about damage to the lower branch of the trigeminal nerve located in the mandibular canal or other areas of nerve fibers.

Numbness of the lip after surgery can be temporary or chronic. Most often, a defect is encountered when:

Plastic.
Implantation.
Treatment of maxillofacial injuries.
Oncological diseases.

Let us consider the appearance of the disorder using the example of dental implantation. This occurs due to injury to the nerve by the needle during the administration of anesthesia or the artificial root being too long. The patient feels discomfort in the lower jaw, swelling of the lips, chin, nose, tongue, cheeks, pain, increased secretion saliva and diction defect.

Treatment should begin at the first symptoms of paresthesia. First of all, you should contact the doctor who performed the operation, consult a dentist, neurologist and physiotherapist. This will allow you to assess the extent of damage and draw up a treatment and diagnostic plan. The sooner this is started, the higher the chances that the discomfort will go away after drug therapy, that is, another operation will not be needed.

Numbness and burning of lips

A burning sensation, numbness, and irritation in the lip area can be a sign of herpes. This viral disease, which manifests itself during colds and other inflammatory processes in the body. If this symptom complex is supplemented by tingling in the teeth, then this is a deficiency of calcium and vitamin D. There are many reasons that cause numbness and burning of the lips, let’s consider the main ones:

Infectious and inflammatory diseases.
Diseases of the endocrine system.
Metabolic disorders (excess vitamin B6, nicotinic acid).
Injuries.
Dental diseases.
Allergic reactions.

Kidney disease is another common cause of paresthesia. A similar thing occurs in diabetics when the sugar level is below or above the required norm. Weakened immunity, oncological diseases, HIV, AIDS also provoke pathology. In order to determine what caused the discomfort and eliminate it, you need to contact a neurologist. The doctor will give directions to the dentist and other specialists.

Swelling and numbness of lips

Loss of sensitivity with some increase in tissue is the body’s reaction to a certain irritant. Swelling and numbness of the lips can occur with mild hyperemia or, conversely, with bluish skin. A person feels fullness and subcutaneous pressure, it becomes difficult to speak and eat.

The main causes of swelling and numbness of the lips:

Allergies to cosmetics, medications or food products– symptoms appeared 10-15 minutes after contact with the irritant. A local irritation reaction affects not only the lips, so swelling may appear on the gums, palate or throughout the entire oral cavity.
Infection - swelling is accompanied by fever and general chills. Lip enlargement occurs gradually with an increasing feeling of fullness. This is possible when an infection is introduced during cosmetic procedures, injuries. Without timely medical intervention, it can cause sepsis.
Swelling after lip tattooing is a normal reaction to the procedure. To normalize the condition, you must follow the cosmetologist’s recommendations for caring for the delicate part of the body. This will prevent infection and restore the normal state of the tissues.
Macrocheilitis is a disease in which the lips become swollen, hyperemic, and sensitivity is impaired. Appears in the background viral infections and other pathologies that reduce the immune system.
Crohn's disease - causes swelling and numbness of the lips, but is accompanied by additional symptoms: diarrhea, abdominal pain, fever.

If swelling combined with numbness lasts longer than 30 minutes, then you should urgently seek medical help (provided that the symptoms are not related to the effects of anesthesia after dental treatment or cosmetic procedures). The doctor collects anamnesis, conducts visual inspection and prescribes a further diagnostic plan.

Treatment depends on the etiology of the disorder. For this they use antihistamines, drugs to reduce inflammation and pain and other medications. If the cause of the discomfort is not determined, then control over the patient’s condition and a number of physiological procedures are prescribed to eliminate the discomfort.

Complications and consequences

Lip swelling is a disorder that occurs for a variety of reasons. Consequences and complications depend on the factors that caused it. Let's take a closer look at what paresthesia can lead to:

Trigeminal neuralgia - if we consider the pathology as a disease in itself, then it is not life-threatening. But her frequent attacks lead to depression and the inability to lead a normal life and eat. The patient begins to lose weight, the immune system weakens, and the psyche is disturbed.
Cervical osteochondrosis – on initial stages for elimination unpleasant symptoms Various analgesics, topical drugs, and NSAIDs are used. If the disease is not treated, the pain increases and more serious medications are needed to eliminate it. May lead to the development of vegetative-vascular dystonia.
An allergic reaction - swelling of the lip can spread to other parts of the face and cause asphyxia. For warning possible consequences, you should consult a doctor and identify the allergen that causes unpleasant symptoms.
Diabetes mellitus - against the background of frequent paresthesias, fragility of blood vessels develops, pathological changes nerve fibers, diabetic coma.
Shingles - paralysis, movement disorders, serious diseases of internal organs, hearing and vision.

In order to avoid the consequences and complications described above, at the first pathological symptoms you must seek medical help.

Diagnosis of numb lips

Symptoms of numbness of the lips are a clear indication for examination of the body. Diagnostics consists of many various procedures aimed at a comprehensive study of the patient’s condition. Let's consider an approximate diagnostic complex:

Collection of anamnesis and analysis of patient complaints

When did sensory disturbances first appear?
Are there any diseases or pathologies with similar symptoms?
Is the disorder related to professional activity?
Availability bad habits(alcoholism, drug addiction, smoking).

Examination by a neurologist

Sensitivity level assessment.
Determination of the zone of numbness.
Identifying associated symptoms (changes in body temperature, pale skin, headaches or muscle pain)

Laboratory research

Blood test to determine glucose levels.
Toxicological analysis (detects signs of intoxication).
Electroneuromyography to determine nerve impulses and their passage along nerve fibers.

Instrumental diagnostics – MRI, CT, ultrasound and more.

During the examination, the doctor assesses the condition of the trigeminal nerve using an x-ray of the nasopharynx and auditory opening. By using ultrasound examination study the condition of the blood vessels, MRI and CT are necessary to examine the posterior cranial fossa. As additional methods serological tests for syphilis and tests to determine the level of protein and cytosis may be prescribed cerebrospinal fluid. Using electroneuromyography, the condition of the facial and optic nerves and brainstem reflexes are assessed.

If the diagnostic results do not reveal any pathologies, the doctor will diagnose idiopathic trigeminal neuropathy. Treatment of the disease takes from several months to several years. All therapy takes place under medical supervision.

Analyzes

The complex of examinations to identify the cause of swollen lips also includes laboratory diagnostics. The tests are not very informative, since in most cases the blood and other biological fluids are normal. That is, today there are no special laboratory parameters, with the help of which neuralgia can be identified as the main cause of loss of sensitivity.

But, despite this, tests make it possible to identify other abnormalities in the body that can also provoke paresthesia. The patient needs to donate blood from a finger and vein, and a urine test. If there are signs of inflammation of the meningeal membranes, then a study of the cerebrospinal fluid is performed (allows meningitis to be excluded). For herpetic causes of loss of sensitivity, an analysis of immunoglobulins A, M, G for herpes types I – III is carried out. Tests should also be taken during the treatment period to monitor the body’s condition, especially if prescribed medications.

Instrumental diagnostics

To identify the cause of loss of lip sensitivity, use various methods. Deserves special attention instrumental diagnostics. It consists of the following procedures:

MRI of the brain and spinal cord.
Ultrasound of the heart.
X-ray of the spine.
Dopplerography (vessels of the neck, abdominal cavity).
Electroneuromyography.
Rheovasography.

Let's take a closer look at the studies that are most often prescribed:

An informative method for studying the structures of the brain and spinal cord, blood vessels, and cranial nerve branches. Allows you to visualize the condition of organs and tissues, identify tumor neoplasms, vascular lesions, sclerosis and other diseases that cause disruption.

CT scan

Used for visualization various organs and structures. In terms of its information content, the method is similar to MRI. Used to identify diseases of the central nervous system that could provoke paresthesia.

Electroneurography

Determines the speed of electrical impulses along the nerve fibers of peripheral nerves. With its help, you can determine the level of nerve damage and its presence, pathogenesis and prevalence of the pathological process.

EEG diagnoses the state of the nervous system and biological electrical activity brain.

Differential diagnosis

There are many diseases causing symptoms numbness of various parts of the body, including lips. Differential diagnosis allows you to identify the true cause of the defect by comparing it with similar pathologies. The patient walks a series diagnostic studies, But Special attention The differentiation process involves consultation with the following specialists:

Neurosurgeon - identifies pathologies of the central nervous system that can cause paresthesia. At serious illnesses prescribes surgical treatment.
Dentist - loss of lip sensitivity is differentiated from dental diseases and impaired sanitation of the oral cavity.
Otolaryngologist - identifies chronic lesions of the nasopharynx, which can cause discomfort not only in the lips, but also in the nose, chin and even tongue.

Differential diagnosis is the final study before making a diagnosis. Its results are compared with other methods, after which a treatment plan is drawn up.

Treatment of numb lips

If loss of lip sensitivity occurs quite often, then such a symptom requires medical attention. Treatment begins with a comprehensive diagnosis, based on the results of which a plan for future therapy is drawn up. If the numbness is associated with prolonged stay in an uncomfortable position, then treatment is not required; it is enough to change the position and the discomfort will go away on its own.

Medical assistance is necessary if numbness occurs for no apparent reason, lasts for a long period of time and is accompanied by additional symptoms.

If the defect appears as a result of injuries to the back, neck or head, then therapy is aimed at restoring normal blood supply to the damaged areas and eliminating damaged nerve endings.
Lip paresthesia may be associated with dental diseases or manipulations performed. If the leakage is associated with anesthesia, then it goes away on its own within 2-3 hours.
If the disorder is caused by vitamin deficiency, then treatment is aimed at eliminating vitamin deficiency. To do this, the patient is prescribed a series vitamin preparations and mineral complexes.
For disorders associated with multiple sclerosis, the patient is prescribed corticosteroids and B vitamins. Attacks are associated with certain environmental conditions, for example, air temperature. Physiotherapy is also used as therapy: massage, acupuncture, yoga.
For facial neuralgia, anti-inflammatory and painkillers are used. Most often, a course of prednisolone is combined with special gymnastics and acupuncture. In some cases, rubbing the face and lips with special solutions restores sensitivity.

Treatment is aimed at restoring normal sensitivity of the affected tissues and preventing their numbness in the future.

What to do if your lips are numb?

If you often experience complete or partial loss of facial sensitivity, then this symptom requires medical attention. What to do if your lips are numb and how to prevent the development of serious pathologies? First of all, it is necessary to monitor the state of the body and correct it at the first signs of a disorder:

Treatment of ENT diseases.
Treatment and prevention of dental problems, sanitation of the oral cavity.
Normalization of metabolism ( healthier food, vitamins, hormonal correction).
Treatment of diseases of the cardiovascular system.
Antiviral and antibacterial therapy.
Prevention of proliferation of connective tissue after operations, injuries, infectious lesions.

Timely treatment of any disorders of the body will prevent the occurrence of diseases that cause paresthesia in different parts of the body.

Medicines

Used to treat sensory impairment various drugs. The doctor selects medications based on the cause of the pathology. In some cases, antiepileptic drugs are effective, as they stop short-term seizures. Analgesics do not help, so drug therapy is combined with physiotherapy, for example, with electrical stimulation of nerves through the skin.

Let's consider popular medications prescribed for numbness of the lips and other symptoms accompanying the disorder:

Phenytoin

Anticonvulsant with analgesic, muscle relaxant and antiarrhythmic effects. It is used in neurosurgery, for trigeminal neuralgia, and epileptic seizures. The dosage is individual for each patient, so it is selected by the attending physician.

Contraindicated for use in cases of impaired renal and liver function, porphyria, intolerance to the active components of the drug, Morgagni-Adams-Stokes syndrome, bradycardia.

Side effects manifest themselves in many organs and systems. But most often, patients encounter the following disorders: confusion, headaches, tremors of the limbs, nervousness, attacks of nausea and vomiting, local allergic reactions.

Carbamazepine

Neurotropic, antiepileptic drug with psychotropic and antidiuretic properties. Stabilizes the membranes of excited neurons, reduces the synaptic transmission of excitatory impulses. Used for trigeminal neuralgia, multiple sclerosis, epilepsy, pain syndrome diabetic neuropathy, alcohol withdrawal syndrome, acute manic state.

Contraindicated for use in hepatic porphyria, during lactation, hypersensitivity to active substances and inhibition of bone marrow hematopoiesis. To eliminate numbness, take 200-400 mg per day with a gradual increase in dosage until the disorder is completely relieved.
Overdose is expressed by the following symptoms: central nervous system depression, drowsiness, tachycardia, vomiting, decreased intestinal motility, urinary retention. There is no specific antidote, so gastric lavage is indicated for treatment.
Side effects most often manifest themselves in the form of disorders of the nervous system (headaches, drowsiness, fatigue, taste disturbances), mental disorders (hallucinations, depressive state), adverse reactions from the gastrointestinal tract (vomiting, abdominal pain, dry mouth, stomatitis) and other reactions.

Cinnarizine

Vasodilator with moderate antihistamine activity. It is used for disorders of peripheral blood supply and associated paresthesia, in post-stroke conditions, after traumatic brain injuries. Tablets are taken after meals, 25-50 mg 2-3 times a day for several weeks/months.

Contraindicated for use in case of hypersensitivity, pregnancy and breastfeeding. In case of overdose, the following appear: adverse reactions: drowsiness, headaches, increased sweating, dry mouth, vomiting, allergic reactions, decreased blood pressure. To eliminate these symptoms, it is indicated symptomatic therapy, since there is no specific antidote.

Antistax

A herbal remedy with an active ingredient is red grape leaves. Stabilizes cell membranes, normalizes vascular permeability, improving their elasticity. It is used for frequent paresthesias and pain after a long stay in an uncomfortable position, with heaviness in lower limbs, venous insufficiency and varicose veins. Capsules are taken in the morning on an empty stomach. Dosage 2-4 capsules per day, duration of treatment 1-3 months.

The drug may cause adverse reactions: urticaria, nausea, rash and itching, discomfort in epigastric region. Contraindicated for use during pregnancy and lactation, for the treatment of sensitivity disorders in pediatric patients and individual intolerance to the active components.

Vazonite

A drug that improves blood microcirculation and its rheological properties. It is used for disorders of peripheral and cerebral circulation, disorders of the blood supply to the eye, hearing loss, trophic changes in tissue during venous or arterial microcirculation. The dosage is individual for each patient. As a rule, for paresthesia of various localizations, take 1-2 tablets per day.

Side effects: nausea, vomiting, loss of appetite, headaches, sleep disturbances, allergic reactions, decreased blood pressure. Contraindicated for use acute heart attack myocardium, massive bleeding and intolerance active ingredients. In case of overdose, attacks of nausea and vomiting, decreased blood pressure, and increased temperature occur. To eliminate them, symptomatic therapy is indicated, since there is no antidote.

All of the above drugs are taken only as prescribed by a doctor. Self-medication can aggravate attacks of numbness and cause a number of additional pathological symptoms.

Neurodiclovitis from lip numbness

Various medications are used to treat sensory impairment. Neurodiclovit for numb lips is included in the category of neurotropic vitamins with non-steroidal anti-inflammatory properties. Contains B vitamins and diclofenac, which effectively reduces pain and inflammation in neuralgia.

The active ingredient of the drug, diclofenac, is non-narcotic analgesic, which reduces inflammatory mediators, reduces swelling, pain, and the intensity of inflammatory processes. B vitamins have neurotropic properties, acting as coenzymes.

Indications for use: prescribed in all treatment regimens for inflammatory degenerative rheumatic diseases, arthrosis, chronic polyarthritis, spondyloarthritis, lumbago, ankylosing spondylitis, neuritis and neuralgic diseases.
The tablets are taken orally, the dosage is individual for each patient. As a rule, patients are prescribed 2-3 capsules per day. The duration of treatment depends on the results of therapy in the first days of using the drug.
Side effects: heart failure, tachycardia, convulsions, dizziness and headaches, leukopenia, changes in taste, tremor of the limbs, decreased visual acuity. Disorders from the gastrointestinal tract are also possible: attacks of nausea and vomiting, disturbances of appetite and stool, epigastric pain, flatulence, stomatitis. In some cases, adverse reactions from the urinary system, allergic reactions, and various mental disorders develop.
Contraindications: intolerance to the active components of the drug, any form of severity of heart failure, ulcerative lesions of the digestive system, hematopoietic disorders, severe kidney and liver failure, lesions of allergic origin. Not used to treat children, during pregnancy and breastfeeding.
In case of overdose, signs of intoxication, development acute form renal failure, neuropathy, seborrheic dermatitis, anemia, abnormal liver enzymes and pain in the heart. To eliminate them, you must stop taking the drug or reduce the dosage and consult your doctor.

Vitamins

Since numbness of the lips can be associated with a deficiency of vitamins B and D, it is very important to replenish it regularly. For this purpose, special vitamin complexes, foods rich in these substances and medications are used. Vitamins are selected by the attending physician, focusing on diagnostic results, especially blood tests.

Let's consider Neurovitan - a balanced complex of B vitamins, the effect of which is due to its rich composition:

B1 – is responsible for the energy metabolism of nerve fibers in a living organism and is necessary for the normal functioning of the nervous system.
Octothiamine is a combination of thioctic acid and vitamin B1. It is characterized by prolonged action and high acid resistance.
Vitamin B2 - riboflavin is one of the main participants in protein, carbohydrate and fat metabolism, which is necessary for the synthesis of hemoglobin.
Vitamin B6 – takes part in the synthesis of neurotransmitters and protein metabolism, improves the functioning of nerve fibers and liver function.
Vitamin B12 - cyanocobalamin is involved in blood formation, the synthesis of myelin and nucleotides, and the development of epithelial cells.

Neurovitan is used in the treatment of neuritis, lesions of the nervous system, paresthesias of various localizations and etiologies, peripheral paralysis, neuralgia of various origins, lumbago. Effective for diseases of the cardiovascular system, immunodeficiency conditions, radiation sickness, anemia, dermatitis. Can be used on a regular basis by persons leading active image life, with an unbalanced diet, smoking or alcohol abuse.

Adult patients are prescribed 1-4 tablets per day for 2-4 weeks, for children and pregnant women 1-3 tablets per day. The medicine may cause allergic reactions in the form of dermatitis. Contraindicated for use if you are intolerant to its components.

Physiotherapeutic treatment

If frequent numbness is not associated with an uncomfortable position, it requires medical attention. After diagnosis and prescribed therapy, the patient needs to undergo a rehabilitation course. Physiotherapeutic treatment can eliminate numbness and prevent its occurrence in the future. The following are considered popular and effective physiotherapeutic methods:

Acupressure - acupressure refers to the Eastern practices of reflex massage. During the procedure, the massage therapist uses his fingers to biologically active points faces.
Ultraphonophoresis - during the procedure, medications are injected into the skin cells using ultrasonic waves.
Acupuncture – acupuncture refers to reflexology. During the session, there is a massage effect on biologically active points of the face and the introduction of medications into the affected area.

The physiotherapy procedures described above stimulate blood supply and lymph flow, have a beneficial effect on skin, eliminating numbness and improving appearance fabrics.

Traditional treatment

Methods alternative medicine very often used to correct numbness of the lips and paresthesia of other parts of the body. Traditional treatment involves the use of various infusions and decoctions from vegetable herbs. To improve blood supply, horse chestnut, willow bark, and birch leaves are suitable; they accelerate blood flow and have vasodilator effect. Consider popular folk recipes:

Take nettle leaves, parsley and viburnum bark in a 2:2:2 ratio and mix with tricolor violet, goldenrod and sweet clover in a 3:3:3 ratio. Pour a couple of tablespoons of the mixture into 500 ml of hot water and simmer over low heat for 5-7 minutes. Let it brew for 5-10 minutes, strain and pour into a thermos. Take ½ cup of the decoction 2-3 times a day after meals.
A handful of celery root, valerian and Dubrovnik herb pour 600 ml of hot diluted boiled water guilt. The product should infuse for 2 hours, after which it must be strained and added 1-2 tablespoons of honey. Take 100 ml regardless of meals.
Pour 10 g of willow bark into 250 ml of boiling water and boil over low heat for 20-30 minutes. The broth should cool, after which it should be strained and taken 15 g 3-4 times a day.
Wash the green geranium leaves well and place on a piece of linen cloth. It is recommended to apply the compress to the area of numbness. The procedure is repeated 2-3 times a day until sensitivity is restored.
Mix horse chestnut bark, yarrow grass, primrose and sweet clover. Pour a couple of tablespoons of the mixture into 1 liter warm water and cook over medium heat for 5-7 minutes. The resulting decoction must be filtered and poured into large capacity and add warm water to it. Soak a couple of pieces of gauze in the resulting liquid and apply them to the site of paresthesia.

Before using traditional methods, you should consult your doctor.

Herbal treatment

Another option for alternative medicine is herbal treatment. Various infusions, decoctions, lotions and rubs can be made from plant materials. Herbs have a minimum of contraindications, but are highly effective. Let's look at a few effective recipes herbal treatments:

Mix 200 g of fresh mint with 100 g of St. John's wort and valerian. Pour 1-2 tablespoons of ingredients into 500 ml of water, bring to a boil and simmer for 15-20 minutes. As soon as the broth has cooled, it needs to be strained and taken 3 times a day, 10-20 g.
Mix 200 g of dry crushed burdock and chamomile with 500 ml of water and boil for 20-30 minutes. Cool the infusion and strain. Take during the day, a couple of hours after meals.
Mix black radish juice with lavender oil 20:1 and gently rub into the area of paresthesia. After this procedure, it is recommended to gently rub the affected area with a woolen cloth.
20 g pharmaceutical chamomile Pour boiling water over it, let cool and strain. The infusion should be used for rinsing. The procedure is carried out for 10-15 minutes 3-5 times a day. This remedy helps with swollen lips and tongue.
Grind 500 g of lemons thoroughly using a meat grinder or blender, add 500 g of honey and 100 g of apricot kernels. All ingredients must be thoroughly mixed until smooth. The medicine is taken on an empty stomach, 1 spoon in the morning and evening for a month.

Homeopathy

To eliminate loss of sensitivity, methods of different operating principles and effectiveness are used. Homeopathy falls under the category of alternative treatments. Its peculiarity is the use of low concentrations of toxic substances.

Exists huge selection homeopathic remedies, used for numbness caused by trigeminal neuralgia and other causes. Most often, patients are prescribed the following drugs:

Agaricus – eliminates stiffness and tension in facial muscles, twitching, itching and burning. Helps with tearing and stabbing pain, feeling of cold.
Cedron - neuralgic pain around the eyes, lips and nose, burning lacrimation. Recurrent attacks of paresthesia, which worsen at night.
Kalmia - partial loss of sensation with stitching pains that worsen in the afternoon. Paresthesia of the spine and limbs.
Magnesium phosphoricum - paresthesia with shooting pains that spread to the lips, teeth, tongue and chin. Unpleasant sensations appear when eating or staying in cold air.
Mezereum is a disorder caused by herpes or trigeminal neuralgia. The patient complains of shooting pains that provoke lacrimation.
Spigelia – paresthesia combined with sudden sharp and stabbing pain, hypersensitivity to touch.
Verbascum - numbness from the lips, spreading to the ears and respiratory organs. Discomfort appears in the cheekbones in combination with a runny nose and lacrimation.
Viola odorata – damage to the nose and periorbital area. Increasing pain, pulsation in the temples, feeling of heaviness.

The above-described drugs are used in 30th dilution; the dosage and duration of therapy are individual for each patient. A combination of several means is possible. All medications are selected by a doctor, since pharmacodynamics, pharmacokinetics, absorption period and other biological reactions have their own nuances and are known only to a specialist.

Prevention

In order to prevent numbness of the lips and impaired sensitivity in other parts of the body, it is very important to monitor your health. Prevention depends on the causes causing disorder and consists of the following rules:

Quitting smoking, drinking alcohol and drugs.
Monitoring blood glucose levels (at risk of developing diabetes).
Blood pressure monitoring.
Balanced diet(5-6 times a day in small portions, consumption of products with high level fiber, avoidance of fried, fatty and spicy foods).
Healthy image life, regular physical exercise, adherence to sleep and rest patterns.
Minimizing stressful situations and nervous tension.

In addition, it is very important to consult a doctor promptly to diagnose and treat any health problems. Since even at first glance insignificant painful symptoms may cause paresthesia.

Forecast

The success of treating complete or partial loss of sensitivity depends on the cause that caused it. If the discomfort is associated with dental diseases, the prognosis is usually favorable. It is enough to contact the dentist, sanitize the oral cavity and eliminate the problems that have arisen. If the cause is more serious, this may worsen the prognosis and lead to serious consequences.

Lip numbness that persists for a long period of time can lead to tissue atrophy and facial paralysis. Therefore, at the first symptoms of a disorder, it is better to consult a doctor. Timely comprehensive diagnostics will allow you to establish the cause of leakage and choose a method of treatment.

Acromegaly, also known as gigantism in common parlance, is a serious neuroendocrine disease. It is caused by increased secretion of the hormone somatotropin, the so-called growth hormone.

Gigantism is usually called acromegaly in patients with childhood and adolescence. Increased output growth hormone in them leads to excessive linear growth. In adult patients, acromegaly is characterized by the proliferation of soft tissues and periosteum, as well as excessive weight gain.

In 99% of cases, acromegaly develops as a result of a pituitary adenoma. Acromegaly occurs pathological increase all internal human organs: heart, lungs, spleen, liver, intestines and pancreas. Their hypertrophy is fraught with tissue sclerosis and the development of multiple organ failure. In addition, a patient with symptoms of acromegaly has increased likelihood formation of benign and malignant tumors.

Acromegaly occurs on average in 50 per 1 million people. The gender of the patient does not matter. Most often, pituitary adenoma and acromegaly, as a consequence, are diagnosed in people 40-60 years old.

Causes of acromegaly

The predominant number of cases of diagnosed acromegaly arise as a result of pure somatotropic adenoma (also known as somatotropinoma). Acromegaly can also be combined. The cause of this type of adenoma is excessive secretion of somatotropin and prolactin or somatotropin and other types of adenopituitary hormones.

So among the causes of acromegaly are pathologies of hormone secretion:

TSH (thyroid stimulating hormone),
LH (luteinizing hormone or luteotropin),
FSH (follicle stimulating hormone),
a-subunits, etc.

The cause of acromegaly in most cases is mutations of somatotrophs. This is the name of a special type of secretory granule of the pituitary gland.

Acromegaly can also develop as a consequence of MEN-1 syndrome (multiple endocrine neoplasia). This disease of hereditary etiology is characterized by the formation of numerous tumors in the pituitary gland, thyroid and thymus glands, adrenal glands, nervous system and gastrointestinal tract.

Symptoms of acromegaly have a slow rate of increase. On average, in adulthood, the disease is diagnosed only 10 years after the manifestation of the first symptoms of acromegaly.

The main symptoms of acromegaly include changes in appearance. It is thanks to them - coarsening of facial features, enlargement of the cheekbones, brow ridges, and lower jaw - that a person may suspect that he has a disease.

The soft tissues of a patient with symptoms of acromegaly are hypertrophied: the tongue, ears, nose, lips, hands and feet are slightly enlarged. As the disease progresses further, the bite changes due to the growth of interdental spaces.

In patients of childhood and adolescence, the main symptom of acromegaly is an excessive rate of linear growth, ahead of all age norms.

Additional symptoms of acromegaly include:

arthralgia ( overeducation cartilage tissue),
increased sweating and excessive activity of the sebaceous glands,
thickening of the top layer of skin,
splanchnomegaly (enlarged spleen)
degeneration muscle fibers, causing decreased performance and low physical activity.

Chronic overproduction of somatotropin in acromegaly can lead to multiple organ failure. Symptom of acromegaly late stage development is myocardial hypertrophy, heart failure and increased intracranial pressure.

In 90% of patients with symptoms of acromegaly, apnea syndrome is diagnosed - a threat of respiratory arrest during sleep caused by the proliferation of tissue in the respiratory tract.

Acromegaly is also a cause of erectile dysfunction in men and disorders menstrual cycle in women of childbearing age.

Diagnosis of acromegaly

Acromegaly is diagnosed based on blood tests for the level of IGF-1 (somatomedin C). At normal indicators It is recommended to conduct a provocative test with a glucose load. To do this, blood is drawn from a patient with suspected acromegaly every 30 minutes 4 times a day.

To visualize the cause of acromegaly - a pituitary adenoma - an MRI of the brain is performed. In diagnosing the disease, it is also important to exclude possible complications acromegaly: diabetes mellitus, intestinal polyposis, heart failure, goiter, etc.

Treatment of acromegaly

The main goal of acromegaly treatment is to normalize the production of somatotropin. For this, the patient is given surgical removal pituitary adenomas. Surgical treatment acromegaly, provoked by small tumors, in 85% of cases leads to normal hormone secretion and stable remission. Surgery acromegaly caused by a large pituitary tumor is effective only in a third of cases.

IN conservative treatment For acromegaly, somatotropin antagonists are used - artificial analogues of the hormone somatostatin: Lanreotide and Octreotide. Thanks to them regular use in 50% of patients it is possible to normalize hormone levels and also cause a reduction in the size of the pituitary tumor.

You can also reduce the synthesis of growth hormone by taking somatotroph receptor blockers, for example, Pegvisomantom. This technique The treatment of acromegaly still needs further study.

Radiation treatment for acromegaly is considered ineffective as a independent method therapy and can only be used as part of comprehensive measures to combat the disease.

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