Duphaston during pregnancy and planning. Important questions about the drug. Instructions for use in the early stages. When to start taking Duphaston when planning pregnancy

Infertility is a problem that many women are familiar with firsthand. And unfortunately, the number of couples who cannot have children is growing every year. Therefore, it is worth examining several times a year, and only after the final conclusion, the doctor can prescribe Duphaston.

The effect of Duphaston on the body

Duphaston affects a woman’s body in almost the same way as progesterone. After all, as you know, this hormone plays a huge role in normal conception and gestation.

What is the role of progesterone in a woman’s pregnancy?

Progesterone also extinguishes such active action male hormones in a woman’s body, which sometimes makes pregnancy difficult.

Progesterone has a positive effect on a woman’s immunity, maintaining it in excellent condition. Since the cause of miscarriages is often precisely the fact that immune cells organisms view the fetus as something foreign and unnecessary for the body, and attack him.

Therefore, the role of progesterone is to ensure that all these phases are passed through normally by the egg, and the pregnancy continues to develop.

Application of "Duphaston"

The duration of the course is from three to six menstrual cycles, after which pregnancy occurs. And it is important to know that if you have successfully become pregnant, you should not stop taking the drug right away, as this can cause a miscarriage. The dosage is reduced gradually.

And despite the indications, everything is very individual, and the doctor will take this into account when prescribing this drug to you.

But they still start taking Duphaston only after ovulation, and stop using it only before menstruation.

Side effects

• Skin rash, which may be accompanied by itching.
• Increased sensitivity of the mammary glands is possible, as well as periodic bloody issues, not during the menstrual period.
• Nausea, stomach pain, liver dysfunction and even jaundice.
• Dizziness and possible headaches.
• Hives.

Instructions for the drug Duphaston - a synthetic analogue female hormone progesterone.

Duphaston is the commercial name of the drug. In the role active substance it contains Dydrogesterone (Dydrogesteronum). Chemical formula: C 21 H 28 O 2 . Name: (9beta,10alpha)-Pregna-4,6-diene-3,20-dione.

Mechanism of action

Duphaston (in some sources - Duphaston) refers to synthetic progestins, i.e., artificially created analogues of the female sex hormone progesterone.

Progesterone and estrogens (estrone, estriol, estradiol) perform a number of vital functions important functions. These hormones shape a woman’s appearance, regulate the menstrual cycle, and, when pregnancy occurs, ensure her normal course followed by delivery.

On the scale of the entire organism, these hormones are involved in almost all types of metabolism (metabolism), affect blood clotting, the amount of blood pressure, synthesis of other hormones, and much more.

Progesterone is called the hormone of the corpus luteum, because it is largely synthesized by the corpus luteum, which is formed at the site of the burst follicle. The peak level of progesterone occurs in the luteal or secretory phase menstrual cycle.

This phase begins from the moment of ovulation (the release of an egg from a ruptured follicle) until the onset of the next menstruation in the absence of fertilization. Main physiological role progesterone – ensuring implantation (immersion) of a fertilized egg into the uterine mucosa and further maintenance normal pregnancy, prevention of complications.

Progesterone prepares the endometrium accordingly - the secretion of endometrial glands (secretory endometrium) increases, and the processes of proliferation (cell division), on the contrary, regress. The formation of mucus in the cervical canal of the uterus decreases. This will hinder the progress of sperm and reduce their ability to further fertilize.

When pregnancy occurs, progesterone is under the influence of human chorionic gonadotropin human (hCG) begins to be secreted by the placenta. At the same time, it relaxes the tone of the muscular lining of the uterus (myometrium), and thereby prevents spontaneous abortions and miscarriages.

Progesterone exerts its effect on the uterus in several ways. It stimulates beta-adrenergic receptors, which relax the uterus, and also accelerates the breakdown of oxytocin and vasopressin, which contract the uterine muscles. In addition, progesterone reduces the sensitivity of the uterus to histamine and serotonin, which increase the contractile activity of the myometrium.

In addition to the maternal genes, the fetus also contains the paternal ones. These paternal genes are foreign to a woman’s body. That's why the immune system triggers reactions aimed at fetal rejection. Progesterone at the local level has an immunosuppressive (suppressing immunity) effect, and thereby preserves the fetus.

Progesterone also reduces the content of prostaglandins in the uterus. These biologically active substances are largely responsible for the appearance PMS symptoms(premenstrual syndrome) - abdominal pain, headache, swelling, increased blood pressure and emotional lability.

Progesterone affects appearance and the function of the mammary glands - ensures roundness of shape, proliferation of functional glandular tissue, and after childbirth stimulates lactation. This hormone is a precursor to other hormones - estrogens, androgens, glucocorticoids, which also regulate the condition reproductive system and metabolism. With estrogens, progesterone is in a state of dynamic equilibrium. Estrogens also ensure the course of many physiological processes.

However, an increase in the level of these hormones (hyperestrogenemia) leads to a number of negative consequences. Hyperestrogenemia is manifested by excessive growth and pathological proliferation of the endometrium. This may cause the development of endometriosis or malignant neoplasms.

Excessive production of estrogen leads to fibrocystic changes in the mammary glands. Under the influence of estrogens, blood clotting and blood glucose levels increase, and salts are retained in the body. Progesterone normalizes all these indicators and stimulates the removal of fluid and salts from the body.

Progesterone carries out its action through specific progesterone receptors located in organs and tissues.

It is quite logical that if there is insufficiency of progesterone, all the functions it performs will be impaired. The risk of endometriosis and malignant neoplasms in the uterus increases. The mammary glands undergo cystic fibrosis with further transformation into cancer.

The menstrual cycle is disrupted. At the same time, its luteal phase is significantly affected. For this reason, infertility often occurs, and if pregnancy does occur, miscarriages and premature birth are possible. The cycle becomes irregular.

Due to the lack of prostaglandins, manifestations of PMS are pronounced. These same manifestations within the menstrual cycle are called dysmenorrhea.

In particular severe cases There is no menstruation at all (amenorrhea). Delayed follicular maturation and differentiation dominant follicle leads to polycystic changes in the ovaries. Polycystic ovary syndrome further aggravates dyshormonal disorders in a woman’s body.

Progesterone deficiency, as a rule, is not absolute, but relative in nature - progesterone is secreted in normal quantities, but there is even more estrogen. The reason for this is inflammatory gynecological diseases or extragenital pathology, mainly connected with other links endocrine system, pituitary gland, thyroid gland.

Luteinizing hormone (LH), produced by the anterior pituitary gland, stimulates the synthesis of progesterone in the corpus luteum. There is a relationship between LH and progesterone Feedback– with an increase in progesterone levels, the synthesis of LH in the pituitary gland slows down.

Insufficient LH is accompanied by progesterone deficiency. During menopause (physiological, or developed as a result of gynecological diseases, surgical interventions) there is an absolute deficiency of progesterone and estrogen.

The only way out in these situations is to compensate for the progesterone deficiency as part of hormone replacement therapy (HRT). For this purpose, synthetic progestins are prescribed, which include Duphaston. The dydrogesterone molecule is similar in structure to the progesterone molecule.

Therefore, the drug has an affinity for progesterone receptors. At the same time, it selectively binds to uterine receptors and does not affect receptors in other organs. Under the influence of Duphaston, the menstrual cycle is normalized, and PMS symptoms disappear. Already during treatment, the ability to conceive and further normal pregnancy appears. Such Negative consequences hyperestrogenemia such as endometriosis, malignant neoplasms in the uterus.

At the same time, Duphaston does not eliminate the ability of estrogens to reduce the level of low-density cholesterol and prevent the development of vascular atherosclerosis.

Duphaston does not affect carbohydrate metabolism and liver condition. The drug does not have the properties of androgens and glucocorticoids, and thus compares favorably with many other synthetic progestins. The drug cannot be used as a means of contraception.

Release forms

Tablets 10 mg.

Dydrogesterone under original name Duphaston is produced in the Netherlands by the multinational pharmaceutical company Abbott and Solvay. The products of this company are popular in the USA, Russia and Western countries. Europe. Abroad, the drug is known under the names Bifaston, Beritox, Terolut, Ginorest. But all these medicines are not imported into Russia. In addition to Duphaston, we prescribe Utrozhestan with the active ingredient progesterone.

Indications

• Endometriosis;
• Infertility due to LH deficiency;
• Dysmenorrhea;
• Menstrual irregularities;
• Complex treatment of PMS;
• Amenorrhea (in combination with estrogens);
• Dysfunctional uterine bleeding;
• Threatened and habitual abortion;
• HRT to prevent proliferative changes in the myometrium in case of taking estrogens in the treatment of disorders associated with menopause.

A little history

Dydrogesterone was synthesized in the 50s of the last century. Production medicine Duphaston was established in the 60s. Since then, the drug has been successfully used in gynecological practice in Russia and abroad.

Synthesis technology

Initially, Dydrogesterone was produced from natural plant materials - soybeans and yams. Now the drug is obtained through organic synthesis reactions aimed at producing a substance with a molecule that is as similar as possible to the molecule of natural progesterone.

In the production of Duphaston tablets, in addition to the main substance Dydrogesterone, auxiliary substances are also used: lactose monohydrate, hypromellose, magnesium stearate, colloidal silicon dioxide, corn starch. For the manufacture of tablet shells, hypromellose, titanium dioxide, and polyethylene glycol are used.

Dosages

The tablets are taken orally on certain days of the menstrual cycle, depending on the indications.

• Endometriosis. Continuously or from 5 to 25 days of the cycle.
• Infertility due to LH deficiency. 1 tablet from 14 to 25 days of the cycle. Treatment should be carried out continuously for at least 6 cycles. The tablets continue to be taken in the first months of pregnancy in order to prevent miscarriage.
• Threatened abortion. Start with a single dose of 4 tablets. Then take 1 tablet for every next 8 hours until the symptoms of threatened abortion disappear.
• Habitual abortion. 1 tablet 2 times a day. Then the dose is gradually reduced.
• PMS. 1 tablet 2 times a day from 11 to 25 days of the cycle.
• Dysmenorrhea. 1 tablet 2 times a day from day 5 to day 25 of the cycle.
• Amenorrhea. 1 tablet 2 times a day from 11 to 25 days of the cycle in a complex with estrogens taken 1 time per day from 1 to 25 days of the cycle.
• Irregular menstrual cycle. 1 tablet 2 times a day from 11 to 25 days of the cycle.
• Dysfunctional uterine bleeding. 1 tablet 2 times a day for 5-7 days. To prevent bleeding, 1 tablet is prescribed 2 times a day from days 11 to 25 of the cycle.
• HRT. 1 tablet for 14 days with a 28-day cycle. When combined with estrogens, take 1 tablet 1 time per day during the last 12-14 days of taking estrogen. If Duphaston is insufficiently effective, its dose can be increased to 2 tablets.

Pharmacodynamics

The drug is quickly absorbed into the gastrointestinal tract. The maximum concentration in blood plasma is formed 2 hours after administration. Plasma protein binding – 97%.

In the liver it undergoes metabolic transformations by hydroxylation of ketone and methyl groups. Binds to glucuronic acid. 56-79% of the drug is excreted through the kidneys in the form of glucuronic acid conjugates. On the first day, 85% of Dydrogesterone is eliminated; over the next three days, the drug is eliminated from the body almost completely.

Side effects

• CNS: headache, migraine, general weakness.
• Gastrointestinal tract: abdominal pain, liver dysfunction, jaundice.
• Reproductive system: increased sensitivity mammary glands, breakthrough uterine bleeding.
• Skin and subcutaneous tissue : peripheral edema, allergic reactions as skin rash, itching, Quincke's edema.
• Blood: hemolytic anemia.

Contraindications

The drug should not be taken in case of individual intolerance to Dydrogesterone or other components. Duphaston is contraindicated in case of malabsorption syndrome (malabsorption in the gastrointestinal tract), as well as in case of a genetically determined disorder in the absorption of galactose or deficiency of the lactase enzyme, which breaks down milk sugar.

Duphaston is contraindicated in Rotor and Dabin-Johnson syndrome. These are types of congenital hepatoses ( functional disorders liver), which, fortunately, are extremely rare. Duphaston is prescribed with great caution to patients whose previous pregnancy was accompanied by itchy skin.

Drug interactions

Duphaston is compatible with all medicines. Rifampicin, Phenobarbital and other drugs that increase the activity of microsomal liver enzymes accelerate the breakdown of Dydrogeterone, and thereby reduce its effectiveness.

Pregnancy and lactation

Dydrogesterone does not penetrate the placental barrier and has no effect on the fetus. Therefore, it can be used during pregnancy. However, the drug penetrates mother's milk. Therefore, if there is a need to take Duphaston, breast-feeding stop.

Storage

Store at a temperature not exceeding 30 0 C. Shelf life – 5 years. The drug is available with a doctor's prescription.

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The drug duphaston is synthetic progesterone.

When using the hormone, women's menstrual cycle is normalized and the threat of miscarriage is eliminated. It does not have the thermogenic, anabolic, estrogenic activity that the natural hormone and drugs made on its basis have.

The product is produced only in film-coated tablets on a plastic blister, 20 pieces per package.

The active substance is dydrogesterone. Each tablet contains 10 mg active substance. To enhance the effect, the following substances are included in the composition:

• hypromellose;
• magnesium stearate;
• lactose monohydrate;
• corn starch;
• colloidal silicon dioxide.

The tablet shell consists of white opadry Y1-7000. It contains titanium dioxide, hypromellose and polyethylene glycol.

The tablet has a biconvex shape. There are engravings on both sides. “S T” is placed on one side, and “155” is placed on the other.

Indications for use

Duphaston tablets are used for progesterone deficiency, manifested by a variety of pathologies:

• infertility, miscarriage;
• dysmenorrhea;
• secondary;
• menstrual irregularities;
• spontaneous abortion;
• ovulation dysfunction;
• uterine bleeding;

The list of diseases for which a synthetic progesterone substitute is prescribed is quite large.

Contraindications

To date, there are no descriptions of negative effects after taking the medication. However, the drug should not be taken if you are allergic to the substances included in the drug and with Rotor and Dabin-Johnson syndromes.

Side effect

All medicines have side effect. Duphaston can cause:

• Headache.
• Its use can cause uterine bleeding, which is eliminated by increasing the dosage of the medication.
• The main thing of any hormonal drug is a hormonal imbalance.

The human body is designed in such a way that each organ of the endocrine system produces a hormone. Its quantity depends on life cycle. If a hormone is present in the body, its production is reduced or stopped completely. When taking Duphaston, the production of your own hormone by the corpus luteum completely stops. That's why this remedy should be prescribed only in cases of extreme necessity, when other means cannot provide assistance.

Precautionary measures

"Duphaston" is a hormone, although synthetic origin. It is prescribed only in cases where the corpus luteum stops producing its own progesterone or its amount is not enough for the normal functioning of the body and maintaining pregnancy. But even in these cases, the drug should be prescribed with extreme caution.

Use during pregnancy

Some women cannot get pregnant due to a lack of progesterone in the body. To compensate for hormone deficiency, it is prescribed various drugs, including Duphaston tablets. It is a progesterone analog created artificially. The main substance, dihydrogesterone, is close in structure to the natural hormone. An artificially produced substance can have the same effect on the body as a natural remedy.

If it is impossible to get pregnant or if the fetus is miscarried, the gynecologist prescribes a series of tests, based on the results of which he selects a progesterone treatment regimen. It is he who is responsible for preserving the fetus and the ability to become pregnant.

"Duphaston" is a hormonal drug that should only be prescribed by a doctor, and in cases where a decrease in progesterone in the female body is laboratory proven. Most often, the drug is prescribed from the second half of the menstrual cycle and continues until the onset of menstruation. If pregnancy does not occur during this period, the doctor will review the treatment regimen.

If pregnancy occurs, it is impossible to abruptly stop taking the drug, since sharp drop the amount of hormone can lead to miscarriage. Therefore, if conception occurs, the woman must continue taking the drug until the doctor stops it. This happens gradually so that the body can begin producing its own hormone.

For some pregnant women synthetic hormone also used during pregnancy. During this period, uterine stimulation may occur. To relax her, Duphaston is prescribed. However, it is worth considering that during administration the intestines also relax, and the mammary glands begin active preparation for lactation. Therefore, a gynecologist can prescribe progesterone not only to help a woman become pregnant, but also to preserve the fetus, creating favorable conditions for its development.

Around the twentieth week, the placenta is so developed that it is able to support the body by producing additional hormones to maintain the pregnancy. During this period, it is advisable to stop taking progesterone. This is done smoothly, otherwise a sharp decline hormones will increase the tone of the uterus and deteriorate the nutrition of the placenta.

Hormone or not

Duphaston is a hormonal drug of artificial origin. It is distinguished from natural only by the absence of androgenic effects and the method of production. It is produced in a laboratory, unlike natural progesterone, which is produced by the corpus luteum of the ovaries.

Analogues of "Duphaston"

There is no identical analogue to the drug. However, there are several drugs with similar effects.

• The main analogue is the drug “Utrozhestan”. The difference between the drugs is the properties of progesterone. Duphaston uses an active substance of synthetic origin, similar in properties to a natural hormone. Utrozhestan uses a plant substance.
• Another analogue is “Inzhestan”. The product is produced in the form of injection solutions. The product contains progesterone.

Only a doctor can decide which hormonal drug to prescribe.

Stopping the drug

There is no general opinion among doctors regarding the discontinuation of the drug, but they are all similar in that only a doctor should discontinue the drug Duphaston.

In each case, the gynecologist individually develops a scheme for discontinuing the hormonal drug under constant monitoring level of progesterone in the blood. It may be contained in normal quantity, and then a cancellation is assigned general principle, and there may be a slight deviation from the norm, up or down. In case of such a failure, the work of the endocrine system is canceled according to special schemes developed specifically for each specific case and strictly under the supervision of a gynecologist.

The regimen may include reducing the dose by one tablet per day or by 1/2. It is possible to accurately determine the dosage by which the intake should be reduced only after determining the level of the hormone. The cancellation procedure may last several days or may take weeks.

In case of irregularity in the menstrual cycle, the doctor may prescribe not only Duphaston, but also its analogues. However, the appointment is made only if a lack of progesterone in the body is confirmed. In other cases, the hormone is not included in the course of treatment.

Treatment with the drug for hormonal imbalance does not always give a positive result. In such situations, the doctor adjusts the dosage.

Bibliography

1. Ascending infection of the fetoplacental system. Glukhovey B.I. 2006, Publisher: MEDpress-inform.
2. Neonatology: national guidelines. UMO stamp medical education. Editor: Volodin N.N. 2007 Publisher: Geotar-Media.
3. Metabolic syndrome and thrombophilia in obstetrics and gynecology. Makatsaria A.D., Pshenichnikova E.B. 2006 Publisher: MIA.
4. Anomalies labor activity: a guide for doctors. UMO stamp for medical education. Podtetenev A.D., Strizhova N.V. 2006 Publisher: MIA.
5. Emergency conditions in obstetrics. Sukhikh V.N., G.T.Sukhikh, I.I.Baranov et al., Publisher: Geotar-Media, 2011.
6. Obstetric risk. Maximum information - minimum danger for mother and baby Radzinsky V.E., Knyazev S.A., Kostin I.N. 2009 Publisher: Eksmo.
7. New honey technology (Methodological recommendations) “Management of premature pregnancy complicated by premature rupture of membranes”

The drug Duphaston - hormonal agent, having quite wide range actions and helping to combat problems of the female genital area. These include polycystic ovary syndrome, irregularities in the menstrual cycle, endometriosis, and even infertility. How does it work in each of these cases?

Features of the drug

Duphaston is an analogue of the female hormone progesterone dydrogesterone, created in a laboratory. It is absolutely safe for the body. The structure of the drug is very similar to the natural hormone.

It has an effect on the uterine mucosa, in particular on the receptors that are most sensitive to it.

Lack of progesterone in the body leads to headaches, sudden changes mood, swollen breasts and abdominal area, excessive fatigue. If this is the period before menstruation, an insufficient amount of the hormone leads to sudden weight gain and severe pain in the lower abdomen. Duphaston helps solve these problems.

Why take it?

Why is Duphaston prescribed in each specific case? Its action depends on the situation.

Before conception

When planning a pregnancy, a woman needs to be tested for the level of progesterone in her blood. If it is underestimated, the doctor will prescribe Duphaston as the main treatment. It will speed up conception and promote light current pregnancy in the first 3-4 months.

There are several cases when treatment with Duphaston is mandatory:

Endometrial problems

When a woman’s body lacks progesterone, the endometrium (uterine lining) greatly increases in size. It can peel away from the walls of the uterus and cause heavy bleeding.

In most cases, Duphaston helps to overcome this disease:

When pregnancy has already occurred

Why is Duphaston prescribed to pregnant women:

1. During pregnancy, the drug reduces the tone of the uterus, which can cause miscarriage or premature birth.
2. Participates in preparing the breast for feeding.
3. Helps the body accumulate fat necessary for bearing a child.
4. Stops the removal process ovum from the uterus (spontaneous abortion).
5. Improves the condition of the endometrium.

Disturbances in the hormonal system

Disturbances may occur in the functioning of a woman's reproductive system. They are called for various reasons. Most often, violations relate to the menstrual cycle. This is dysmenorrhea ( severe pain lower abdomen before the onset of menstruation and during its process), very pronounced premenstrual syndrome(PMS), amenorrhea (no menstruation).

How does Duphaston combat these problems? Regular menstruation is a sign that a woman’s body clearly performs all its functions. The duration of the menstrual cycle is on average 28 days. If after this time there are no periods, then a failure has occurred. It is usually caused by disturbances in hormonal system, in particular, a lack of progesterone. Duphaston is prescribed to bring the menstrual cycle back to normal.

What does a proper cycle look like? In the second week of the cycle, the ovarian membrane ruptures, after which a mature egg emerges. At the same time, the corpus luteum appears, which is responsible for the production of progesterone. A sufficient amount of it launches such important processes, like growth and renewal of the endometrium. It also allows the body to carry a child.

Low levels of progesterone prevent the task from being completed, and Duphaston helps the mother’s body cope with the task assigned to it.

The moment progesterone levels return to normal, the menstrual cycle becomes regular. Sometimes disturbances in the hormonal system lead to the appearance of tumors. Cysts form in the cavity of the corpus luteum. They will resolve on their own if there is enough female hormone in the body. IN otherwise the cyst will continue to grow. In this case, taking Duphaston is mandatory.

Polycystic

Polycystic ovary syndrome is a disease associated, again, with disturbances in the hormonal system. Duphaston is prescribed to normalize hormonal background.

Women who suffer from polycystic ovary syndrome are more at risk of miscarriage than others. On early stages they may have a miscarriage or spontaneous abortion. Premature birth or isthmic-cervical insufficiency (the cervix can no longer hold the fetus in the womb) often occurs.

For polycystic disease, Duphaston is prescribed until the 16th week of pregnancy. It was during this period that the placenta itself begins to produce progesterone.

Important Rules

Duphaston is a hormonal drug. Therefore, it should be prescribed exclusively by the attending physician. He also determines the dose and duration of treatment. The use of Duphaston must obey certain rules:

How to use

The dosage of the drug depends on the specific case.

Sometimes Duphaston is prescribed for menopause. It is usually combined with other drugs that restore a woman’s hormonal levels. The duration of treatment is 14 days.

Duphaston is a synthetic hormone that has a huge effect on a woman’s body. It not only restores the endometrium and promotes its renewal, but also prevents the formation of cysts and polyps in the uterus. Duphaston promotes conception and fixation of the embryo in the uterus, after which the fetus can grow and develop. Thanks to him the risk premature birth is reduced to a minimum.

This drug normalizes the menstrual cycle and restores a woman's ability to have children. But it is worth remembering that this is a hormonal medicine, and it should only be prescribed by a doctor.

Duphaston is a hormonal drug prescribed to women to correct the menstrual cycle. The drug is used to treat various kinds hormonal disorders. It is important for women planning a pregnancy to know how Duphaston and ovulation are interconnected.

Duphaston is a biconvex tablet white. The drug contains dydrogesterone in an amount of 10 mg. This active ingredient determines the operating principle hormonal medication.

Dydrogesterone is a progestogen that is active when internal reception. Its molecular structure, physical and chemical properties the substance is similar to natural progesterone. Normally, this hormone is released in the second phase of the menstrual cycle. If the natural process is disrupted, unpleasant circumstances may arise:

• luteal insufficiency;
• endometriosis;
• endometrial hyperplasia;
• uterine bleeding;
• irregular cycle;
• miscarriage or infertility.

Duphaston will help solve the problem. It is important to take it correctly in every special case, since any problem requires individual approach. Treatment with Duphaston is carried out not only in women reproductive age. This drug is actively prescribed to patients for hormone replacement therapy after menopause.

Once in a woman’s body, the pills immediately begin to compensate for the lack of natural progesterone. After two hours, the concentration of the active substance reaches its maximum.

Duphaston when planning pregnancy

— Duphaston does not block ovulation; when taken from the 11th or 14th day of the cycle, ovulation will in any case occur in the mode in which the menstrual cycle operates.

However, Duphaston does not act as a stimulant. The medicine does not promote follicle growth and opening, that is, it does not stimulate ovulation. Although it does not suppress it.

On what day of the cycle should I start taking it?

Are Duphaston and ovulation compatible? A qualified gynecologist must examine the patient before prescribing any hormonal medication. Used for diagnostics different techniques: ultrasound, folliculometry, blood test for hormones. If the doctor decides that taking Duphaston is advisable, he will prescribe this medicine, focusing on the timing of ovulation. If the patient trusts her doctor, there is no need to worry about whether Duphaston affects ovulation. As we have already written, these pills will not prevent the onset of ovulation, even if they were taken before it.

Based on the results of studies and tests, the gynecologist may recommend that the patient use the medication from the 15th, 16th, 18th or any other day, until the next bleeding begins. The daily dose of medication is also regulated in accordance with individual characteristics female body. It is important to take the pills at the same time.

The classic scheme for using the second phase hormone involves taking the drug one capsule, starting from day 14, for 11 days. On the 25th day of the cycle, the medicine is discontinued.

If one capsule per day is prescribed, you should drink it in the morning. If it is necessary to use two tablets, take them in the morning and evening, with an interval of 12 hours. This method of use allows you to maintain the maximum concentration of the active substance in the blood.

Install optimal time To start using the tablets, you can use ultrasound diagnostics. There is also a more budget-friendly way. Knowledgeable patients combine an ovulation test and Duphaston. Positive result home research suggests that the release of the egg will occur within 1-2 days. This means that you should start taking the medication after 3-4 days to ensure you get it on time.

If a woman has a long and regular cycle that never fails, then you can calculate the time to take the medication calendar method. It is, of course, less reliable than an ovulation test. The duration of the menstrual cycle is determined by the duration of its first phase. This means that in a healthy representative of the fairer sex, the period of progesterone release is always 10-14 days.

The follicular phase can vary larger range: from 7 to 20 days. With a long regular cycle Calendar calculation of the time of taking the drug is made as follows: from the expected last day- after which the beginning of a new menstruation is expected - 11 should be subtracted.

Duphaston for anovulatory cycle

Each healthy woman during the year has 1-2 cycles in which there is no ovulation. This condition is often characterized by a long delay. Anovulatory cycles can reach a duration of 40-50 days. This causes discomfort to the patient, especially when planning pregnancy. The same drug that replaces natural progesterone will help speed up the completion of such a cycle.

Duphaston for anovulation is prescribed from the 11th day of the cycle. You can determine that an egg is not expected to be released using an ultrasound. During the examination, the uzologist discovers that there is no dominant follicles, and the endometrium is completely unprepared for conception. Tell me when it starts another menstruation, in this case it is impossible. Taking Duphaston will create the illusion of the second phase for the body. As soon as a woman stops taking the medication, which is usually recommended on day 25 of the cycle, menstruation will soon begin. In the absence of ovulation, the medicine is taken 2 tablets per day - morning and evening.

With frequent anovulatory cycles gynecologists prescribe hormone therapy. It involves stimulating the growth of follicles in the first phase and maintaining the functioning of the corpus luteum in the second. Often this method helps in getting pregnant.

What if conception occurs?

If a woman becomes pregnant while using Duphaston, then stopping its use on the 25th day of the cycle (as the instructions advise) is strictly prohibited. Otherwise, the new state may be interrupted. The dose of hormonal support should be gradually reduced from 14-16 weeks, abandoning it completely by the middle of the gestational period. The same regimen should be followed if Duphaston is prescribed when there is a threat of miscarriage in the first trimester.

Duphaston - analogue natural progesterone. The drug does not cause unpleasant consequences, unlike other androgenic progestogens. Despite all the advantages of the drug, it is unacceptable to use it on your own. Good experience use of medication by friends or positive reviews should not become calls for self-medication. If you have problems with menstrual cycle the patient needs to see a gynecologist and get individual scheme taking a hormonal drug.