Instructions for use of Menopur: action and composition. "Menopur" for the strong half of humanity. Visitor survey results

Menopur is part of the group of hormonal drugs. This drug is used for disorders of the reproductive system and ovaries, in particular. It is prescribed not only to women, but also to men when sperm production is impaired in order to normalize testosterone levels. The medicine is one-component. It is distinguished by a narrow scope of application, as well as many contraindications.

Other names and classification

On Latin- Menopur.

International nonproprietary name

Human menopausal gonadotropin, or hMG.

Trade names

Registration number

P No. 015764/01.

ATX

Composition and dosage forms

The drug is produced in the form of a lyophilized powder. It is used to prepare a solution through which injections are performed. Additionally, the kit includes a solvent. The powder can be purchased in bottles of 5 or 10 pcs. volume 2 ml. The substance used as a solvent is contained in 1 ml ampoules.

Menotropins are used as the main component. Their concentration in 1 bottle of lyophilisate is 75 IU.

Other components in the powder:

• lactose monohydrate;
• polysorbate;
• sodium hydroxide;
• hydrochloric acid.

These components do not exhibit hormonal activity, but contribute to obtaining the required structure of the drug substance. The solvent contains sodium chloride, hydrochloric acid, and water for injection.

Pharmacological group

Follicle stimulating agent.

pharmachologic effect

The main component is human menopausal gonadotropin. This hormone belongs to the group of menotropins. The active substance is highly purified. It contains follicle-stimulating and luteinizing hormones. Main component obtained from the urine of postmenopausal women.

The pharmacodynamics of the drug is based on stimulating follicle growth. At the same time, there is an increase in estrogen, the maturation of eggs is activated, the endometrial tissue of the uterus grows, ovulation occurs, and the possibility of fertilization appears. The principle of action of the drug on male body is to stimulate sperm production and normalize testosterone levels. The remedy in question is often used along with others hormonal medications, for example, together with human chorionic gonadotropin, or hCG.

Thanks to this principle of action, the product is used in preparation for egg implantation during IVF. Its advantage is normalization menstrual cycle, although this happens artificially. The effect of forced stimulation of follicular growth and maturation may disappear if it is not possible to restore hormonal background and natural cycle.

When carrying out therapy with this drug, there is an increase in the concentration of follicle-stimulating hormone by 2 times, and luteinizing hormone by 1.5 times.

After intramuscular injection the substance is absorbed gradually; complete absorption occurs within 7 hours. Peak activity medicine occurs within 6-24 hours. Then the concentration of the drug decreases. The half-life is 4-12 hours.

Why is Menopur prescribed?

The main task of this remedy is to normalize hormonal levels.

Women

Indications for use:

• infertility caused by hypothalamic-pituitary disorders; V in this case the main objective therapy - growth of at least 1 follicle, since it is difficult to achieve better results;
• lack of ovulation in polycystic ovary syndrome;
• ovarian hyperstimulation during assisted reproductive techniques (for example, with a long IVF protocol) aimed at enhancing the growth of many follicles, and the process must be controlled.

For men

The drug is recommended for use in pathological conditions such as azoospermia, oligoasthenospermia, if their cause is hypogonadotropic hypogonadism (primary or secondary). In both cases, spermatogenesis is activated, which is due to the effect on the germ cells of the seminiferous tubules.

Directions for use and dosage of Menopur

The lyophilisate for preparing the solution should be diluted with a special solvent, which is included in the kit by the manufacturer. Injections can be performed different ways: subcutaneously and intramuscularly. Moreover, the second option is more preferable, since it promotes rapid and complete absorption of the active substance.

How to breed

The drug is prepared for use immediately before administration. It cannot be prepared in advance. Before use, evaluate the structure of the substance: the solvent should not contain third-party fractions and other visible particles. Do not shake it vigorously.

The dosage is selected individually. In this case, estrogen levels are taken into account. To prepare the medicinal substance, you need to combine the contents of the ampoules with lyophilisate and solvent.

How to prick

Therapy for women with polycystic ovary syndrome begins with small doses: 75-150 IU per day. Duration of treatment - 7 days. If the therapy is well tolerated by the body, the amount of the drug is gradually increased. It is permissible to increase the dose no more than once a week and by no more than 37.5 IU. It is necessary to control the daily amount, its limit is 225 IU.

In the absence of positive dynamics, the course of treatment is stopped and, after a short break, continued, but using larger dosages.

When positive result was received, after completion of therapy the next day an injection is given with a dosage of the main component of 5000-10000 IU (one time). Then sexual intercourse is recommended.

If the goal of therapy is to stimulate the growth of numerous follicles, the initial dose changes - up to 225 IU per day. After 5 days, the amount of the main component increases. However, it is permissible to increase the dose by no more than 150 IU at a time. In this case, the maximum daily amount of the drug is 450 IU. If a positive result has been achieved, after completing the course of treatment, the next day an injection is given with a concentration of the main component of 10,000 IU (one time).

In order to stimulate spermatogenesis, the drug in question is prescribed after ineffective therapy with drugs containing hCG. In this case, it is necessary to continue the course of chorionic gonadotropin (2000 IU 2 times a week). Additionally, therapy with the drug in question is carried out 3 times a week; The dosage for a single administration is 75 IU. The minimum acceptable duration of treatment is 4 months. If there is no positive result, the hCG course is continued with the same concentration, but the amount of Menopur is increased to 150 IU.

For oligospermia, a drug containing human chorionic gonadotropin (5000 IU 3 times a week) and the drug in question (75-150 IU 3 times a week) are prescribed.

If the goal of therapy is to activate spermatogenesis, first treatment with chorionic gonadotropin is carried out (1000-3000 IU three times a week). When the patient's condition returns to normal, the course of therapy with the drug in question is continued (75-150 IU three times a week).

special instructions

Treatment is carried out after a thorough examination: the spermogram is assessed, the likelihood of developing hypothyroidism, tumors of the pituitary gland, and hypothalamus is clarified.

If necessary, therapy for these pathological conditions is prescribed.

After completing a course of Menopur, the risk of multiple pregnancy increases, ectopic pregnancy. It should be taken into account that the likelihood of spontaneous abortion after therapy with this drug increases.

It is noted that the risk of developing pathologies in the fetus is also slightly higher than during conception. naturally. However, there is no clinical evidence for this.

If ovarian hyperstimulation syndrome develops as a result of treatment, the drug is immediately discontinued.

When a man's blood contains an excess amount of follicle-stimulating hormone, the drug in question does not provide the required level of effectiveness.

The drug does not affect the central nervous and cardiovascular system body, which means that it is permissible to drive a vehicle during treatment.

During pregnancy and breastfeeding

Not assigned.

Side effects of Menopur

The drug provokes the appearance of numerous negative reactions:

• stomach ache;
• intensive stimulation of the ovaries (this increases the risk of developing pathological conditions such as ovarian torsion, thromboembolism);
• nausea;
• excessive gas formation;
• headache;
• negative reactions at the point of drug administration: pain, swelling, redness;
• violation of water electrolyte balance;
• arthralgia.

At long-term use the process of formation of antibodies to the main component begins, which reduces its effectiveness.

Men can develop a pathological condition such as gynecomastia. At the same time, the size of the mammary gland increases.

Contraindications

The drug is not prescribed in a number of cases:

• an increase in the size of the ovaries, a developing cyst not caused by polycystic disease;
• hyperprolactinemia;
• bleeding, the cause of which is unknown;
• pathological conditions genital organs incompatible with pregnancy, for example, uterine fibroids;
• diseases thyroid gland and adrenal glands;
• malignant tumor in the ovaries, uterus or mammary glands ah (in women), prostate cancer, testicular cancer (in men);
• increased levels of follicle-stimulating hormone, which may be a consequence of ovarian failure;
• tumors in the hypothalamus, pituitary gland, as well as androgen-dependent formations;
• individual intolerance to the main component or other compounds in the drug.

Overdose

Such cases have not been recorded. However, theoretically there is a risk of developing ovarian hyperstimulation syndrome.

The consequence of this condition is an increase in the size of the ovaries, painful sensations lower abdomen, overweight, nausea, vomiting, changes in stool structure, shortness of breath and various pathological conditions accompanied by impaired urination.

No treatment is required. If you stop taking the drug, the symptoms will disappear on their own.

Interoperability and Compatibility

It is noted that simultaneous use Menopura and clomiphene citrate enhance the effect of the drug - intensive growth of follicles is noted.

In order to reduce activity pituitary function During therapy with GnRH agonists, it is recommended to increase the dose of the drug in question.

It is permissible to use the medicine together with drugs containing human chorionic gonadotropin.

With alcohol

Manufacturer

Ferring GmbH, Germany.

Conditions for dispensing from pharmacies

The product in question is offered by prescription only.

Price

Average cost - 24,500 rubles.

How to store

The drug should be kept in a room where the air temperature does not exceed +25°C.

Analogs

Substitutes that can be prescribed instead of the drug in question:

• Menogon;
• Pergonal;
• Humegon;
• Puregon;
• Cetrotide;
• Pergoveris;
• Menopur Multidose.

We prepare and administer the multidose correctly. Menopur

Menopur - mechanism of action.

Infertility is one of the problems that has tormented women for more than a hundred years, but with environmental degradation and harmful effects external factors and poor heredity, more and more patients are suffering from this problem.

But medicine also does not stand still, inventing more and more drugs for treatment.

One of them is the drug "Menopur", which is one of the ten most popular in the CIS countries.

pharmachologic effect

A drug such as Menopur can be classified as a gonadotropin that stimulates ovulation, although the main difference from other tablets is that it is based on human gonadotropin.

“Menopur” contains FSH and LH in equal proportions, since it is made from the urine of women during menopause.

Main Impact The drug is aimed at increasing estrogen levels in the blood, stimulating follicle growth and normalizing the endometrium.

As for men, they can be prescribed the drug "Menopur" in cases where they need to increase testosterone levels and stimulate spermatogenesis, increasing the chances of fertilization. Since then the effect is directly on the seminal canals.

Composition and release form

The drug "Menopur" is sold in the form of bottles, but you need to start the course only after consulting a gynecologist

Main active component there will be menotropin in the amount of 75 IU.

But effectiveness is achieved due to other substances in the preparation: lactose monohydrate, polysorbate, hydroxide, hydrogen acid.

Since the drug is used together with a solvent, for better absorption it contains sodium chloride, acid and purified water for injection.

The drug "Menopur" is sold in the form of ampoules with solvents in packs of 5 and 10 pieces each.

Indications for use

Most common reasons infertility

The use of the drug "Menopur" is allowed only after visiting the hospital, passing tests and developing individual course from the doctor.

Injections are usually used in several cases:

• Infertility due to anovulation, polycystic ovary syndrome, when taking clomiphene does not produce results;
• To control ovarian hyperstimulation, follicle stimulation during infertility treatment, artificial insemination;
• Stimulation of spermatogenesis in men;
• Treatment of hypoganodism.

In other cases, the drug should be used very carefully, only in in some cases under the supervision of a doctor.

This could be seborrhea, cancer prevention, normalization of hormone levels. Then the technique, duration of the course and dosage of injections may differ. of this medicine.

Contraindications

There are also a number of contraindications in which taking the drug "Menopur" is prohibited or the course may differ or be shortened, and you should immediately inform your doctor about this:

One of the contraindications is an ovarian cyst, a hobby of size

• • • Abnormal development of the genital organs;
    • Bleeding and vague vaginal discharge;
    • Oncology of the genital organs;
    • Ovarian failure;
    • Pregnancy;
    • Breastfeeding period;
    • Tumors in the hypothalamus and pituitary gland;
    • Intolerance to some components of the drug "Menopur".

If you have one of the contraindications, then you need to find an alternative treatment. The same applies to situations where problems began after taking the medicine. This may be preceded by a number of side effects.

Side effects

In the first days of taking Menopur, most patients may experience side effects, which are associated with the body’s reaction, stimulating the follicles.

Single, rare, common and very common side effects occur:

• • • Ovarian hyperstimulation;
    • Pain, burning sensation in the lower abdomen;
    • Pain during sexual intercourse;
    • Headache, migraine;
    • Nausea and vomiting;
    • Edema;
    • Hematomas, bruises at the injection site;
    • Gynecomastia.

There are more dangerous manifestations after injections of "Menopur", which consist of torsion of the ovaries, the appearance of other symptoms, and worsening of existing ones.

This is what ovarian torsion looks like

If side effects occur in a severe form, for more than five days, you also need to go to the hospital.

Drug interactions

It is worth saying that no drug interaction studies have yet been conducted with the drug Menopur.

Although when combined with Clomiphene, you may encounter an increased reaction of the follicles.

You can learn more about the drug Clomiphene here.

If you take the drug "Menopur" with agonists, you will have to increase the dosage of the first drug in order to achieve the desired reaction ovaries, stimulate follicle growth.

Regarding joint reception with alcohol, drugs for epilepsy and tuberculosis, then negative reactions was not identified.

Menopur and alcohol

There are no clear contraindications when using Menopur together with alcohol, but it is better to avoid it to improve the results of treatment.

Since alcohol reduces the activity of sperm, reduces the activity of follicles, complicates fertilization and the passage of the zygote through the fallopian tube.

It is better to consult your doctor in advance about combining alcohol with this drug.

Instructions for use and dosage

Menopur is taken as an intravenous injection, but before this you need to prepare a solution from a bottle and water for injection in a syringe. Although doctors recommend doing this only before administering the drug Menopur.

Usually the dosage and duration of the course are developed by the doctor, depending on the problem and special contraindications in patients.

The minimum dose of Menopura for the treatment of infertility in women is 15-100 IU, approximately two bottles per day. 48 hours after the first injection of Menopur, diagnostics are carried out to determine the quality of the follicles and the reaction of the ovaries. If it is absent, then the dosage is increased.

If it is necessary to induce ovulation, then take 5000-10000 IU two days after the start of the Menopur course.

Regarding the treatment of men and stimulation of spermatogenesis, they are administered 1000-3000 IU three times a week. After a few months, an examination is carried out and an additional 75-150 IU of Menopur injections are administered per day.

Cases of overdose with Menopur have not yet been established, but if the dose is increased without a doctor’s permission, the following symptoms may appear:

• Nausea;
• Vomit;
• Ovarian enlargement;
• Change in body weight;
• Diarrhea;
• Dyspnea.

Then you need to go to the hospital or see your doctor, although most symptoms of an overdose with Menopur go away on their own after a couple of weeks.

special instructions

Before starting a course of injections with Menopur, you must undergo a full examination by a doctor, have your partner’s sperm analyzed, and be treated for kidney or liver failure, examine ovarian cysts or tumors for malignancy.

You need to understand that taking the drug "Menopur" can stimulate multiple pregnancies naturally. Although miscarriages may occur early stages pregnancy after fertilization.

Regarding oncology, taking Menopur injections does not affect this fact, although patients often encounter fetal pathologies.

The main danger is that the drug "Menopur" leads to ovarian hyperstimulation, then you need to consult a doctor, treat the symptoms and refuse injections of this drug.

Price for the drug

You need to buy Menopur injections separately from the solvent for injections, so for the first set of 10 pieces you need to pay about 11,000 rubles, and for a package of solvent you will have to pay almost 12,000 rubles. It's about about injections of 75 IU.

If necessary, you can select substitute analogues with a more affordable cost.

Drug name	Price	Purchase	Pharmacy
Menopur lyophilisate for injection 75 IU plus 75 IU n1 ampoule with solvent	1270 rub.	Buy
Menopur lyophilisate for injection 75 IU plus 75 IU n10 ampoules with solvent	12700 rub.	Buy

Analogues substitutes

Regarding analogues of the drug "Menopur", we can distinguish such as Menogon, Humog, Bravel and Fostimon, although Luveris is no less effective.

They all have the same active ingredient, pharmacological action and indications for use. The price fluctuates around 5,000 rubles per bottle with a dosage of 75 IU.

The active ingredient in Menopur substitute preparations is gonadotropin or folitropin beta.

But before the appointment, you need to consult a doctor, get tested and start the course without interruption from Menopur injections.

Photos of analogues:

Merional Humog

The description is valid on 09.06.2016

• Latin name: Menopur
• ATX code: G03GA02
• Active substance: Menotropins
• Manufacturer: Ferring (Germany)

One bottle includes 75 IU (FSH) and 75 IU luteinizing hormone (LG).

Additionally: sodium hydroxide, lactose monohydrate, hydrochloric acid, polysorbate 20.

One ampoule with solvent includes: saline (0,9%) sodium chloride .

Menopur is produced in the form of an injection lyophilisate (powder) in 2 ml bottles No. 5 or No. 10 complete with a solvent in 1 ml ampoules No. 5 or No. 10.

Pharmacodynamics and pharmacokinetics

Menopur belongs to the group of medicinal products menopausal gonadotropin human, includes as active ingredients menothoropines FSH And LH (75 IU:75 IU) and has a high degree of purification. The basis for obtaining the drug is women's urine , allocated during the period postmenopausal .

The use of this medication in women leads to an increase in blood levels estrogen , stimulation of maturation and development ovarian follicles , as well as to proliferation (growth) endometrium .

Administration of the drug to men stimulates the secretion testosterone , increasing its plasma level, and activates spermatogenesis , by acting in the seminiferous tubules on Sertoli cells .

With intramuscular administration of Menopur, plasma Cmax FSH observed after 6-24 hours, after which it gradually decreases. T1/2 menotropins takes 4-12 hours.

Indications for use

Women are prescribed Menopur for:

• diagnosed infertility , due to violations in (to stimulate growth dominant follicle );
• carrying out additional reproductive methods stimulation development multiple follicles for the purpose of conception.

For men, the drug is indicated for:

• oligoasthenospermia or azoospermia , due to primary or secondary hypogonadotropic hypogonadism , for stimulation spermatogenesis (in combination with medicinal drugs human chorionic gonadotropin a person, for example, with Horagon ).

Contraindications

Before injecting Menopur, you need to make sure that the patient does not have:

• pathologies of the adrenal glands and/or thyroid gland ;
• pregnancy;
• tumors localized in the hypothalamic-pituitary region;
• lactation;
• hyperprolactinemia ;
• personal hypersensitivity to menotropins (means including FSH and/or LH ), as well as other ingredients of the lyophilisate;
• persistent ovarian enlargement or presence of cysts , not associated with polycystic ovary syndrome ;
• prostate cancer or others androgen-dependent tumor formations in men;
• uterine fibroids or developmental anomalies of the female genital organs incompatible with the possibility of conception;
• vaginal bleeding unknown origin;
• primary ovarian failure ;
• uterine cancer , mammary glands , ovaries .

Side effects

Sometimes during Menopur therapy the following was observed:

• colicky pain;
• mastalgia ;
• multiple pregnancy ;
• sharp increase in renal excretion estrogen ;
• weight gain;
• uncomplicated moderately severe ovarian enlargement ;
• decrease in blood pressure ;
• education ovarian cysts ;
• oliguria ;
• arthralgia ;
• nausea/vomiting;
• redness, edema /itching in the area of ​​injection;
• manifestations hypersensitivity (including temperature rise and skin rash );
• gynecomastia in men;
• antibody formation , reducing the effectiveness of the drug (very rarely with prolonged use);
• ovarian hyperstimulation syndrome : (strong stomach pain e; weight gain; nausea /vomit ; hypovolemia ; increase in plasma level red blood cells , due to a decrease in plasma volume; ascites ; electrolyte disturbances; hemoperitoneum ; thromboembolic syndrome ; hydrothorax ).

Menopur, instructions for use (Method and dosage)

Instructions for use of Menopur allow for subcutaneous (s.c.) or intramuscular (i.m.) administration of the drug, after diluting the lyophilisate in the supplied solvent (immediately before injection).

When diagnosed infertility , due to violations in hypothalamic-pituitary system (to stimulate growth dominant follicle ), the dosage regimen is set individually. Optimal dosage and the duration of treatment is selected based on Ultrasound of the ovaries , blood concentrations estrogen and further clinical picture. About maturation dominant follicle can be judged based on the increase in plasma levels estrogen .

Overdose

There have been no reports of overdose with Menopur.

Interaction

Menopur can be prescribed in combination with a medication Horagon , which is human chorionic gonadotropin person, to activate ovulation in women, after stimulation of follicular growth and activation spermatogenesis in men.

Terms of sale

Menopur is a prescription medication.

Storage conditions

The lyophilisate with solvent must be stored at temperatures up to 25°C.

Best before date

2 years from the date of release.

special instructions

If the patient has tumors of the hypothalamic-pituitary system , insufficiency of the adrenal cortex, hypothyroidism , hyperprolactinemia , hemoconcentration, appropriate therapy should be carried out before using Menopur.

During treatment infertility it is necessary to conduct a preliminary assessment of the condition ovaries . The criteria for such an assessment are: Ultrasound and determination of plasma level estradiol . Throughout the course of treatment, similar studies must be initiated daily or every other day.

The possibility should be taken into account ovarian hyperstimulation against the background of the use of Menopur, manifested by clinically significant symptoms after administration Horagon for the purpose of activation ovulation and characterized by the formation of large ovarian cysts . In this case, it is possible that hydrothorax And ascites , accompanied arterial hypotension , oliguria and thromboembolic syndrome.

If the first symptoms are detected ovarian hyperstimulation (including pain and/or neoplasms in the abdomen, determined by ultrasound or palpable) the therapy must be stopped immediately!

When identifying ovarian hyperstimulation injections should be discontinued Horagon for the purpose of activation ovulation .

During treatment with Menopur and it similar drugs quite often there is a development multiple pregnancy .

Use of Menopur for the treatment of men with high plasma levels FSH , which indicates the presence primary hypogonadism , as a rule, is ineffective.

• Alterpur ;
• Gonal-F ;
• Ovitrel ;
• Luveris ;
• Decayed ;
• Follitrope ;
• Puregon ;
• Horagon ;
• Pergoveris ;
• Ecostimulin ;
• Bravelle ;
• Elonva .

• Gonadotropin menopausal ;
• Merional ;
• Menogon ;
• HuMoG .

Due to its main action aimed at the possibility conception and offensive pregnancy , Menopur is not used in pediatrics.

During pregnancy and lactation

Reviews about Menopur

Women who have ever been prescribed this remedy, mostly leave positive reviews about Menopur on forums created to discuss problems conception . Reviews of Menopur for ECO This drug is characterized as quite effective and in most cases does not cause any side effects.

Many patients who have undergone egg stimulation using the drug Menopur, achieved a long-awaited pregnancy that led to birth healthy child. Naturally, such therapy requires clear indications, serious preparation, consultations with a competent doctor and does not provide an absolute guarantee of conception, and for some women it will not be suitable in principle. But in the absence of contraindications and pathologies incompatible with pregnancy, it significantly increases the chance of motherhood.

Menopur price, where to buy

Menopur": instructions, price, reviews, description, doses

Why is the drug "Menopur" needed? The instructions for the drug, its methods of use and dosage will be described in this article. From it you will also learn about what indications this medication has, whether it has side effects and contraindications, what patients say about it, what is its cost, etc.

Composition, release form of the medicinal product

In what form is the drug "Menopur" sold? The instructions for use of the medicine contain information that this drug is available in the form of a lyophilisate, which is intended for the preparation of a solution for intravenous or subcutaneous injection.

The medicine is a white or practically white briquette without any odor. It also comes with a colorless and transparent solvent.

What does the drug "Menopur" contain? The instructions say that active substance The medication contains follicle-stimulating and luteinizing hormones. It will also include Excipients in the form of polysorbate 20, lactose monohydrate, sodium hydroxide and hydrochloric acid.

The solvent is sodium chloride solution (isotonic).

Packaging of the drug

The drug is sold in 2 ml bottles. Along with it comes a solvent (ampule with 1 ml of substance). One cardboard package can contain 5 or 10 sets.

Pharmacological action of the drug

What is the drug "Menopur"? The instructions for use indicate that this drug is a highly purified human gonadotropin (menopausal). It belongs to the group of menothoropins, and also contains LH and FSH in a ratio of 1 to 1. The medication is obtained from postmenopausal women’s urine.

For the fairer sex this remedy stimulates endometrial proliferation, maturation and growth of ovarian follicles, and also causes an increase in the level of estrogen in the blood.

As for the stronger sex, this drug leads to an increase in testosterone concentration. In addition, it stimulates spermatogenesis through its effect on tubule (sperm) cells.

Pharmacokinetics of the drug

How long does it take for Menopur to be absorbed? The instructions state that the maximum concentration of FSH in the blood is achieved approximately 7-24 hours after intramuscular administration. After this, its volume gradually decreases. The half-life of menotropins is 5-12 hours.

Indications for use of the medication

The instructions for the drug "Menopur" indicate that it can be used not only by representatives of the weaker sex, but also by representatives of the stronger sex.

So, let's look at the indications for use for women:

• for carrying out reproductive techniques (auxiliary) for the purpose of conception (that is, to stimulate the growth of follicles);
• for the treatment of infertility, which is caused by hypothalamic-pituitary disorders (to stimulate the growth of the 1st dominant follicle).

For what purposes are men prescribed the drug Menopur? Instructions, reviews, application will be presented below. As for the indications, they include the following:

Are there any contraindications for the medication?

When should the drug Menopur (lyophilisate) not be prescribed? Instructions for use include the following contraindications:

• tumor of the hypothalamic-pituitary region;
• abnormal development of the genital organs, as well as the presence of uterine fibroids, which are incompatible with pregnancy;
• diseases of the adrenal glands and thyroid gland;
• hyperprolactinemia;
• enlargement of the ovaries (persistent), the appearance of cysts (if the disease is not associated with polycystic ovary syndrome);
• cancer of the ovaries, uterus or mammary glands;
• vaginal bleeding of unknown origin;
• pregnancy time;
• prostate cancer, as well as other tumors (androgen-dependent) in representatives of the stronger sex;
• lactation time;
• sensitivity (increased) to menotropins, as well as medications that contain FSH or LH.

Medicine "Menopur": instructions for use, abstract

The description of this medication was presented above. As for this section of the article, in it we will tell you about the dosage in which the drug in question should be taken.

The drug is administered intramuscularly. The injection solution is prepared only before use using the solvent included in the kit.

If the attending physician has not prescribed any other therapy, it is recommended to adhere to the following regimen.

For the treatment of infertility, which is caused by problems with the hypothalamic-pituitary region, in order to stimulate the growth of the first dominant follicle, the dose of the drug is set individually. The optimal volume of the drug, as well as the duration of therapy, are selected based on an ultrasound scan of the ovaries, clinical observation and determining estrogen levels. By the way, it is by the last value that the maturation of the follicle is judged.

If there are no ovarian reactions, then the volume of the product is gradually increased until the follicles grow and estrogen levels increase. This dose is left unchanged until the moment when the concentration in the blood of the latter reaches the preovulatory value. If there is a sharp increase in estrogen levels at the beginning of stimulation, it is advisable to reduce the dosage of the drug.

After the last injection, 5-10 thousand IU of hCG are administered once, 2 days later. This is done to induce ovulation.

Side effects of the drug use

Now you know how much Menopur should be administered. Instructions, application, reviews are presented in this article. However, I would like to note that this drug can cause a number of side effects.

• Endocrine system: increased (sharp) excretion of estrogen in the urine, mastalgia, formation of ovarian cysts, moderate enlargement of the ovaries, gynecomastia (in the stronger sex).
• Digestive tract: vomiting, colicky pain, nausea.
• Local reactions: redness, swelling, and itching at the injection site.
• Allergy: skin rash, fever, arthralgia, the formation of antibodies, which leads to a decrease in the effectiveness of the treatment.
• Others: oliguria, increased body weight, decreased blood pressure, multiple pregnancy.

It should also be noted that the use of the drug in question may cause the appearance of ovarian hyperstimulation syndrome. Early signs of such a deviation include pain (severe) in the lower abdomen, vomiting, ascites, weight gain, nausea, hypovolemia, electrolyte imbalance, hydrothorax, increased number of red blood cells, hemoperitoneum and thromboembolic syndrome.

Special instructions for using the product

What do you need to know before using Menopur? The instructions and reviews state that before prescribing this medication, the patient must undergo appropriate treatment (in the presence of adrenal insufficiency, concomitant hypothyroidism, a tumor of the hypothalamic-pituitary region, hyperprolactinemia).

Before starting infertility therapy, it is necessary to assess the condition of the ovaries. For this purpose they carry out ultrasonography, and also check the level of estradiol in the blood. During the entire course, these studies must be carried out every other day or every day.

It must be taken into account that while using hMG drugs there is a possibility of developing ovarian hyperstimulation. As a rule, it becomes clinically pronounced only after administration of the drug for the purpose of ovulation and manifests itself in the form of cyst formation large sizes. In such cases, patients may experience hydrothorax, ascites, thromboembolic syndrome, and hypotension.

When the first symptoms of ovarian hyperstimulation appear, drug therapy should be stopped immediately.

When treated with hMG, multiple pregnancies often occur.

Representatives of the stronger sex with high level FSH in the blood is ineffective.

What is the cost of the medicine?

Reviews about the drug

Exists great amount positive feedback about the drug "Menopur". According to them, this drug is a good treatment for infertility, increasing the likelihood of conception several times. By the way, large quantity patients develop multiple pregnancies after using this drug.

The only disadvantage of the medicine in question is its cost. Most patients cannot afford such a drug. Although pharmacists claim that the price of this medication is completely justified. After all, after him correct use there is a huge probability of a long-awaited conception and, as a consequence, the birth of a long-awaited child. Therefore, most young couples who cannot conceive a baby purchase this product without any hesitation.

Reviews for Menopur

Release form: Lyophilisate

Matches the indications

Price from 385 rubles (cheaper by 6410 rubles)

Matches the indications

Price from 440 rubles (cheaper by 6355 rubles)

Matches the indications

Price from 1035 rubles (cheaper by 5760 rubles)

Matches the indications

Price from 2505 rubles (cheaper by 4290 rubles)

• Tradename:
• Dosage form:
• Compound:
• Description:
• Pharmacological properties:
• Indications for use.
• Contraindications
• Directions for use and doses
• Use in women
• Use in men
• Side effects
• Overdose.
• Interaction with other drugs.
• Special instructions.
• Release form.
• Storage conditions.
• Best before date.
• Conditions for dispensing from pharmacies:

Tradename: Menopur

International nonproprietary name:

Dosage form:

Compound:

Active substance: follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in a 1:1 ratio.
Excipients: Lactose monohydrate, polysorbate 20, sodium hydroxide, hydrochloric acid.
Solvent— 1 ampoule with 1 ml of solvent contains isotonic solution sodium chloride and diluted hydrochloric acid to create pH.

Description: The contents of the bottle with the active substance is a white or almost white, odorless, lyophilized briquette. The contents of the ampoule with solvent is a colorless transparent solution.

Pharmacotherapeutic group:

Follicle-stimulating and luteinizing agent

Pharmacological properties:

Indications for use.
Among women:

• for infertility caused by hypothalamic-pituitary disorders (in order to stimulate the growth of one dominant follicle);
• when carrying out assisted reproductive techniques for conception (stimulation of the growth of multiple follicles).

For men:

• stimulation of spermatogenesis in azoospermia or oligoasthenospermia, caused by primary or secondary hypogonadotropic hypogonadism(in combination with human chorionic gonadotropin therapy, such as Choragon ®).

Contraindications

• persistent enlargement of the ovaries or the occurrence of ovarian cysts not caused by polycystic ovary syndrome;
• developmental abnormalities of the genital organs or uterine fibroids incompatible with pregnancy;
• vaginal bleeding of unknown etiology;
• ovarian, uterine or breast cancer;
• primary ovarian failure;
• prostate cancer or any other androgen-dependent tumors in men;
• pregnancy;
• lactation period;
• diseases of the thyroid gland and adrenal glands;
• tumors of the hypothalamic-pituitary region; hyperprolactinemia;
• hypersensitivity to menotropins (drugs containing luteinizing and/or follicle-stimulating hormones) and other ingredients of the drug;

Directions for use and doses
Menopur is administered intramuscularly or subcutaneously. The injection solution is prepared immediately before administration using the supplied solvent. Unless otherwise prescribed, the following treatment regimen is recommended.

Side effects
From the outside endocrine system: mastalgia, a sharp increase in estrogen excretion in the urine, in men - genicomastia.
From the ovaries: moderate (uncomplicated) enlargement of the ovaries and the formation of ovarian cysts.
Ovarian hyperstimulation syndrome: severe pain in the lower abdomen, nausea, vomiting, weight gain (early signs); hypovolemia, hemoconcentration (an increase in the number of red blood cells in the plasma associated with a decrease in plasma volume), electrolyte imbalance, ascites, hemoperitonium (the presence of blood in abdominal cavity), hydrothorax, thromboembolic syndrome.
Allergic and immunopathological reactions: arthralgia, in rare cases reactions develop hypersensitivity(fever, skin rash).
Local: pain, redness, swelling or itching at the injection site.
From the gastrointestinal tract: Sometimes nausea, vomiting, and colicky pain may occur.
Others: oliguria, decreased blood pressure, weight gain, multiple pregnancy.
In very rare cases, when long-term use the drug may form antibodies, which leads to a decrease in the effectiveness of the therapy.

Overdose.
Currently, no cases of overdose of Menopur have been reported.

Interaction with other drugs.
Menopur can be used in combination with the drug Horagon ® (human chorionic gonadotropin, hCG) in women - to induce ovulation, after stimulating follicle growth, in men - to stimulate spermatogenesis.

Special instructions.
Before starting treatment with the drug, it is recommended to carry out appropriate treatment for hypothyroidism, adrenal insufficiency, hyperprolactinemia, tumors of the pituitary gland or hypothalamus, and correction of hemoconcentration.
Before prescribing Menopur, the condition of the ovaries should be assessed: ultrasound examination, estradiol level in the blood.
During the course of treatment, these studies should be carried out daily or every other day. Careful monitoring of the patient's condition is an integral part of the treatment.
Treatment with human menopausal gonadotropins (hMG) can often lead to ovarian hyperstimulation, which becomes clinically evident after administration of hCG (human chorionic gonadotropin) for ovulation and manifests itself in the formation of ovarian cysts big size. This is combined with fluid accumulation in the abdominal cavity (ascites), pleural cavity(hydrothorax), and is accompanied by a decrease in the volume of urine excreted (oliguria), a decrease blood pressure(hypotension) and blockage blood vessels(thromboembolic phenomenon).
At the first signs of hyperstimulation: abdominal pain, palpable by a doctor or detected by ultrasound volumetric formations lower abdomen - treatment should be stopped immediately!
In the presence of pregnancy, the above-described manifestations of hyperstimulation syndrome worsen, the duration of their manifestations increases, and this condition can lead to a threat to the patient’s life.
In cases of hyperstimulation, human chorionic gonadotropin (hCG) should not be administered for the purpose of ovulation.
When treated with hMG drugs, multiple pregnancies often develop.
In men with high levels of FSH in the blood (indicative of primary testicular failure), Menopur is usually ineffective.

Release form.
Bottle with the drug: 75 IU LH + 75 IU FSH in a colorless type I glass bottle with a rubber stopper, aluminum rim and flip-off plastic cap.
Ampoule with solvent: 1 ml in colorless 1 ml glass ampoules of type I with the possible application of a colored dot and/or one or two colored rings.
5 bottles of the drug and 5 ampoules of solvent in one cardboard or plastic cell package, one or two cell packages in a cardboard box with instructions for use.

Storage conditions.
At a temperature not exceeding 25°C in a place protected from light. Keep out of the reach of children!

Best before date.
2 years. The drug should not be used after the expiration date indicated on the packaging.

Instructions for use of Menopur: action and composition

Quite a lot married couples suffers from infertility. In such cases, they come to the rescue modern medicines, stimulating ovulation in women and spermatogenesis in men. Menopur is one such drug.

Menopur is a drug that belongs to the menotropins. It contains human menopausal gonadotropin hormone. This substance is obtained from the urine of postmenopausal women.

Composition and pharmacological action

Menopur is available as a lyophilisate white for intramuscular or subcutaneous injections. It contains 75 IU (international units) follicle-stimulating hormone(FSH) and 75 IU luteinizing hormone(LG). The drug is packaged in 2 ml bottles. Each package contains 5 or 10 bottles. The medicine also comes with 1 ml ampoules of solution Sodium chloride in quantities of 5 or 10 pieces. Sodium chloride is used as a solvent.

There is a release form of the medicine called Menopur Multidose. This medication contains 600 IU FSH and 600 IU LH, or 1200 IU FSH and 1200 IU LH. The Menopur Multidose kit includes a syringe with a solvent: metacresol and water for injection.

The use of Menopur causes an increase in the level of sex hormones in women. The medicine promotes the maturation and growth of follicles in the ovaries and the proliferation of the endometrium.

In men, the drug increases testosterone levels and promotes spermatogenesis.

After an injection of Menopur, 6 to 12 hours later, the highest level of follicle-stimulating hormone in the body is observed. The drug is excreted primarily through the kidneys. Half the dose of the drug leaves the body within 4 to 12 hours.

Indications and contraindications for use

Menopur is used to treat female and male infertility. Women are prescribed this medicine in the following cases:

In the treatment of male infertility, the drug is used to stimulate sperm production. Menopur is effective if disorders reproductive function connected with gonadotropin deficiency. This medicine helps with a small number and reduced quality of sperm or when they complete absence in the ejaculate. Sometimes treatment is supplemented with the use of chorionic gonadotropin drugs (for example, Pregnil or Choragon).

Before injecting the drug, you must make sure that there are no contraindications to Menopur injections. The instructions for use warn that the drug should not be used for certain diseases and conditions.

Menopur is contraindicated people of both sexes if they have:

• increased levels of the hormone prolactin;
• tumors of the pituitary gland or hypothalamus;
• thyroid dysfunction;
• adrenal diseases;
• hypersensitivity to menotropins.

Women should not receive injections of the drug under the following conditions:

• pregnancy;
• period breastfeeding child;
• uterine bleeding;
• myoma;
• congenital pathologies of the genital organs incompatible with pregnancy;
• primary ovarian failure;
• ovarian cysts;
• ovarian enlargement not associated with polycystic changes;
• malignant tumors of the mammary glands and internal genital organs.

Men are contraindicated to inject Menopur in the following cases:

• for prostate cancer;
• in the presence of hormone-dependent tumors.

Side effects of Menopur

Some patients may experience unwanted symptoms after Menopur injections. Instructions for use indicate the following side effects of the drug:

special instructions

If patients have blood thickening, then before therapy it is necessary to correct this condition. And also, before prescribing the drug, you need to undergo a course of therapy in the presence of hyperprolactinemia, diseases of the adrenal glands and thyroid gland, tumors of the hypothalamus and pituitary gland.

If a man is diagnosed with primary hypogonadism, then treatment with Menopur is ineffective. The presence of such a disease is indicated by a high level of FSH in the blood.

Before using the drug, a blood test for sex and gonadotropic hormones is necessary. To avoid ovarian hyperstimulation, injections of the drug are carried out under ultrasound control. If hyperstimulation does occur, then Menopur is discontinued and choriogonic gonadotropin preparations are not administered.

The instructions for use do not clearly indicate the compatibility of Menopur with alcohol. But during the course of treatment it is better to stop drinking alcohol. Alcohol negatively affects the maturation of sperm in men and follicles in women. If, during treatment with Menopur, a woman experiences long-awaited pregnancy, then drinking alcohol is even more undesirable.

Menopur treatment regimen

Before use it is necessary open the ampoule with sodium chloride and dissolve the drug. The prepared solution is administered subcutaneously or intramuscularly. Subcutaneous route of administration is preferable, So medicinal substance better absorbed.

Dosage of the drug during treatment female infertility determined individually. The amount of the drug administered depends on the results of the ultrasound examination and the level of estradiol in the blood.

The drug is used in the same way during IVF. Menopur injections are the first stage of preparation for this procedure. For IVF, it is necessary to obtain several eggs, which are then collected by puncture, fertilized in vitro, and the embryos are transferred to the uterus.

How to administer the drug yourself

After your doctor has prescribed Menopur, you can administer it yourself at home. To do this, you must follow the following step-by-step instructions:

Storage conditions, price and analogues of the drug

Menopur, as well as ampoules or a syringe with a solvent can be store for 2 years at a temperature of no more than +25 degrees in a place protected from sun rays. The drug can be purchased at the pharmacy by doctor's prescription.

There are many analogues of the drug based on the active substance:

The price of these drugs is also quite high, from 5,000 rubles for 1 bottle of 75 IU.

Patients often wonder which drug is best for stimulating ovulation. It can be said that Menopur has more natural composition than its counterparts. After using Menopur, women are less likely to develop such side effects, How overgrowth hair or weight gain. And also after injections of the drug, severe ovarian hyperstimulation usually does not occur. However, due to the natural nature of Menopur's components, more long-term treatment and prescribing higher doses compared to analogues.

Why is the drug "Menopur" needed? The instructions for the drug, its methods of use and dosage will be described in this article. From it you will also learn about what indications this medication has, whether it has side effects and contraindications, what patients say about it, what its cost is, etc.

Composition, release form of the medicinal product

In what form is the drug "Menopur" sold? The instructions for use of the medicine contain information that this drug is available in the form of a lyophilisate, which is intended for the preparation of a solution for intravenous or

The medicine is a white or practically white briquette without any odor. It also comes with a colorless and transparent solvent.

What does the drug "Menopur" contain? The instructions state that the active substance of the medication is follicle-stimulating, and it also includes excipients in the form of polysorbate 20, lactose monohydrate, sodium hydroxide and hydrochloric acid.

The solvent is a solution (isotonic).

Packaging of the drug

The drug is sold in 2 ml bottles. Along with it comes a solvent (ampule with 1 ml of substance). One cardboard package can contain 5 or 10 sets.

Pharmacological action of the drug

What is the drug "Menopur"? The instructions for use indicate that this drug is a highly purified human gonadotropin (menopausal). It belongs to the group of menothoropins, and also contains LH and FSH in a ratio of 1 to 1. The medication is obtained from postmenopausal women’s urine.

In the fairer sex, this drug stimulates the proliferation of the endometrium, the maturation and growth of ovarian follicles, and also causes an increase in the level of estrogen in the blood.

As for the stronger sex, this drug leads to an increase in testosterone concentration. In addition, it stimulates spermatogenesis through its effect on tubule (sperm) cells.

Pharmacokinetics of the drug

How long does it take for Menopur to be absorbed? The instructions state that the maximum concentration of FSH in the blood is achieved approximately 7-24 hours after intramuscular administration. After this, its volume gradually decreases. The half-life of menotropins is 5-12 hours.

Indications for use of the medication

The instructions for the drug "Menopur" indicate that it can be used not only by representatives of the weaker sex, but also by representatives of the stronger sex.

So, let's look at the indications for use for women:

• for carrying out reproductive techniques (auxiliary) for the purpose of conception (that is, to stimulate the growth of follicles);
• for the treatment of infertility, which is caused by hypothalamic-pituitary disorders (to stimulate the growth of the 1st dominant follicle).

For what purposes are men prescribed the drug Menopur? Instructions, reviews, application will be presented below. As for the indications, they include the following:

Are there any contraindications for the medication?

When should the drug Menopur (lyophilisate) not be prescribed? Instructions for use include the following contraindications:

• tumor of the hypothalamic-pituitary region;
• abnormal development of the genital organs, as well as the presence of uterine fibroids, which are incompatible with pregnancy;
• diseases of the adrenal glands and thyroid gland;
• hyperprolactinemia;
• enlargement of the ovaries (persistent), the appearance of cysts (if the disease is not associated with polycystic ovary syndrome);
• cancer of the ovaries, uterus or mammary glands;
• vaginal bleeding of unknown origin;
• primary ovarian failure;
• pregnancy time;
• prostate cancer, as well as other tumors (androgen-dependent) in representatives of the stronger sex;
• lactation time;
• sensitivity (increased) to menotropins, as well as medications that contain FSH or LH.

Medicine "Menopur": instructions for use, abstract

The description of this medication was presented above. As for this section of the article, in it we will tell you about the dosage in which the drug in question should be taken.

The drug is administered intramuscularly. The injection solution is prepared only before use using the solvent included in the kit.

If the attending physician has not prescribed any other therapy, it is recommended to adhere to the following regimen.

Women

For the treatment of infertility, which is caused by problems with the hypothalamic-pituitary region, in order to stimulate the growth of the first dominant follicle, the dose of the drug is set individually. The optimal volume of the drug, as well as the duration of therapy, are selected based on ultrasound of the ovaries, clinical observation and determination of estrogen levels. By the way, it is by the last value that the maturation of the follicle is judged.

So how should you use Menopur? The method of use and dosage of the medicine are always indicated in the attached instructions. The initial volume of the drug can be 75-150 IU (or 1-2 bottles per day).

If there are no ovarian reactions, then the volume of the product is gradually increased until the follicles grow and estrogen levels increase. This dose is left unchanged until the moment when the concentration in the blood of the latter reaches the preovulatory value. If there is a sharp increase in estrogen levels at the beginning of stimulation, it is advisable to reduce the dosage of the drug.

After the last injection, 5-10 thousand IU of hCG are administered once, 2 days later. This is done to induce ovulation.

For men

How should representatives of the stronger sex use the drug "Menopur"? The instructions say that to stimulate spermatogenesis, men need to administer 1-3 thousand IU of hCG three times a week. They do this until normalization. After this, for several months, the medication is administered three times a week at 75-150 IU (or 1-2 bottles).

Side effects of the drug use

Now you know how much Menopur should be administered. Instructions, application, reviews are presented in this article. However, I would like to note that this drug can cause a number of side effects.

• Endocrine system: increased (sharp) excretion of estrogen in the urine, mastalgia, formation of ovarian cysts, moderate enlargement of the ovaries, gynecomastia (in the stronger sex).
• Digestive tract: vomiting, colicky pain, nausea.
• Local reactions: redness, swelling, and itching at the injection site.
• Allergy: fever, arthralgia, formation of antibodies, which leads to a decrease in the effectiveness of the treatment.
• Others: oliguria, weight gain, low blood pressure, multiple pregnancy.

It should also be noted that the use of the drug in question may cause the appearance of early signs of such a deviation include pain (severe) in the lower abdomen, vomiting, ascites, weight gain, nausea, hypovolemia, electrolyte imbalance, hydrothorax, increased number of red blood cells, hemoperitoneum and thromboembolic syndrome .

Special instructions for using the product

What do you need to know before using Menopur? The instructions and reviews state that before prescribing this medication, the patient must undergo appropriate treatment (in the presence of adrenal insufficiency, concomitant hypothyroidism, a tumor of the hypothalamic-pituitary region, hyperprolactinemia).

Before starting infertility therapy, it is necessary to assess the condition of the ovaries. To do this, an ultrasound examination is performed, and the level of estradiol in the blood is checked. During the entire course, these studies must be carried out every other day or every day.

It must be taken into account that while using hMG drugs there is a possibility of developing ovarian hyperstimulation. As a rule, it becomes clinically pronounced only after administration of the drug for the purpose of ovulation and manifests itself in the form of the formation of large cysts. In such cases, patients may experience hydrothorax, ascites, thromboembolic syndrome, and hypotension.

When the first symptoms of ovarian hyperstimulation appear, drug therapy should be stopped immediately.

When treated with hMG, multiple pregnancies often occur.

In representatives of the stronger sex with high levels of FSH in the blood, this medication is ineffective.

What is the cost of the medicine?

How much does Menopur cost? Instructions and the price of this product are presented in this article. The cost of this medicine is very high. For 1 bottle of the drug you will have to pay about 1000-1400 Russian rubles. Considering average rate treatment in 5-10 days, such therapy is very expensive for the patient.

This page provides a list of all analogues of Menopur 75 by composition and indication for use. A list of cheap analogues, and you can also compare prices in pharmacies.

• Most cheap analogue Menopur 75:
• The most popular analogue of Menopur 75:
• ATX classification: Gonadotropin menopausal
• Active ingredients/composition: menotropin

Cheap analogs of Menopur 75

When calculating the cost cheap analogues Menopur 75 the minimum price was taken into account, which was found in the price lists provided by pharmacies

Popular analogs of Menopur 75

The list of drug analogues based on statistics of the most requested medicines

All analogs of Menopur 75

The above list of drug analogues, which indicates substitutes Menopur 75, is the most suitable because they have the same composition of active ingredients and coincide in indications for use

Analogues by indication and method of use

To compile a list of cheap analogues of expensive drugs, we use prices that are provided to us by more than 10,000 pharmacies throughout Russia. The database of drugs and their analogues is updated daily, so the information provided on our website is always up to date as of the current day. If you have not found the analogue you are interested in, please use the search above and select the medicine you are interested in from the list. On the page of each of them you will find everything possible options analogues of the sought-after medicine, as well as prices and addresses of pharmacies where it is available.

How to find a cheap analogue of an expensive medicine?

Menopur 75 price

Menopur 75 instructions

INSTRUCTIONS
on the use of the drug
Menopur 75