Piracetam and cinnarizine combined course. Can everyone drink Cinnarizine? Conditions for dispensing from pharmacies

Presented are analogues of the drug piracetam + cinnarizine* (piracetam + cinnarizine*), in accordance with medical terminology, called “synonyms” - drugs that are interchangeable in their effects on the body, containing one or more identical active ingredients. When selecting synonyms, consider not only their cost, but also the country of production and the reputation of the manufacturer.

Description of the drug

Piracetam is a nootropic drug. Activates metabolic processes in the brain by enhancing energy and protein metabolism, accelerating the utilization of glucose by cells and increasing their resistance to hypoxia. Improves interneuronal transmission to the central nervous system and regional blood flow in the ischemic area.

Cinnarizine is a selective blocker of slow calcium channels and an antagonist of histamine H1 receptors. It has been established that it inhibits the entry of calcium ions into cells and reduces their content in the plasma membrane depot. Reduces the tone of the smooth muscles of arterioles, reduces their response to biogenic vasoconstrictors(catecholamines, angiotensin and vasopressin). It has a vasodilating effect (especially in relation to cerebral vessels, enhancing the antihypoxic effect of piracetam), without having a significant effect on blood pressure. Shows moderate antihistamine activity, reduces excitability vestibular apparatus, increases sympathetic tone nervous system. Increases the elasticity of red blood cell membranes, their ability to deform, and reduces blood viscosity.

List of analogues

Note! The list contains synonyms Piracetam + Cinnarizine* (Piracetam + Cinnarizine*), having similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from of Eastern Europe: KRKA, Gedeon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Reviews

Visitor survey results

Visitor Performance Report

Visitor Report of Side Effects

Visitor Cost Estimation Report

Visitor frequency report per day

Visitor Dosage Report

Visitor start date report

Visitor report on reception time

Visitor report on patient age

Visitor reviews

Official instructions for use

Instructions
By use of the drug

PHESAM ®
PHEZAM®

Trade (proprietary) name of the drug: Phezam ® / Phezam ®

Dosage form:

Compound:

Description: capsules- hard, cylindrical gelatin capsules white, № 0.
Capsule contents- powdery mixture, from white to almost white, the presence of conglomerates is allowed, which, when pressed with a glass rod, easily turn into powder.

Pharmacotherapeutic group:

ATX Code: N06BX

Pharmacological properties

Pharmacokinetics

Indications for use:

Contraindications:

Carefully:
Parkinson's disease.

Directions for use and dosage:

Side effect:

Interaction with other drugs:

Special instructions:

Driving cars and robot with mechanisms.
During treatment, care should be taken when managing vehicles and working with machinery and equipment.

Release form:

Storage conditions:

Best before date:

Conditions for dispensing from pharmacies:

Manufacturer:

Representative office in Moscow:
127051, Moscow, st. Trubnaya, 17/4, building 2

The information on the page was verified by physician-therapist E.I. Vasilyeva.

The drug Cinnarizine- a medicine that is prescribed mainly for the brain. This is a drug that inhibits the penetration of calcium ions into muscle cells heart and blood vessels from intercellular space. This achieves expansion coronary arteries and peripheral arteries and arterioles, is produced vasodilator effect.

Some experts consider Cinnarizine obsolete and prefer to prescribe it for treatment over modern analogues, similar in mechanism of action and achieved effects. Let's consider what analogues of Cinnarizine exist and what can be replaced this drug if necessary.

Cavinton or Cinnarizine - which is better?

Cavinton is a drug whose main component is vinpocetine. It has a neuroprotective and antioxidant effect, has a beneficial effect on blood circulation and metabolism in the brain, as well as on rheological characteristics blood. Most often, this medicine is used for cerebral circulatory insufficiency accompanied by mental or neurological disorders.

Cavinton is similar in effect to Cinnarizine. However, at the same time, Cinnarizine has virtually no effect on blood pressure, which is valuable for the treatment of patients with blood pressure problems. Only a doctor can determine which drug is best to use, depending on the diagnosis and concomitant pathologies.

Cinnarizine or Vinpocetine – which is better?

Vinpocetine is used to correct cerebrovascular disorders. This natural preparation, the main ingredient of which is an alkaloid from the Vinca minor plant. The drug helps to increase blood supply to ischemic areas of the brain by relaxing vascular smooth muscle. The drug also has antiaggregation and antihypoxic effects.

Comparing the drugs Cinnarizine and Vinpocetine, it can be noted that the latter has a smaller amount side effects and is made from plant materials. In addition, when treating with Vinpocetine, patients with liver and kidney diseases do not require a dosage reduction. However, some experts question the effectiveness of Vinpocetine.

Piracetam, Cinnarizine or Phezam - which is better?

Piracetam is a medicine belonging to the group of nootropic drugs. The mechanism of its action is not completely clear, but it is believed that the drug has positive influence on metabolic processes and blood circulation in the brain, helps improve memory, attention, and mental activity.

Cinnarizine is not an analogue of Piracetam, but is often prescribed in combination with this drug. Concomitant use these drugs give a particularly high positive effect when chronic failure cerebral circulation. Phezam is a medicine containing as active ingredients piracetam and cinnarizine.

Cinnarizine or Mexidol - which is better?

Mexidol is a drug based on ethylmethylhydroxypyridine succinate, which has antihypoxic, nootropic, anticonvulsant, anxiolytic effects, and increases the body's resistance to stress. It also improves blood circulation in the brain, has a positive effect on rheological properties blood. The drug appeared relatively recently, and its research is still ongoing. As a rule, it is prescribed not as a monotherapy drug, but in combination with other drugs, one of which may be Cinnarizine.

Vasobral or Cinnarizine – which is better?

Vasobral is combination drug, which is prescribed for cerebrovascular accidents. It contains two active components: alphadihydroergocriptine (ergot derivative) and caffeine. The drug has an effect on the receptors of the central nervous system, helps reduce the permeability of vascular walls, thins the blood, improves blood circulation and metabolic processes in the brain. In addition, Vasobral provides preventive action at .

Comparing Cinnarizine and Vasobral, it is worth noting that the latter helps reduce blood pressure, while Cinnarizine has almost no effect on it. Therefore, for hypotension, Cinnarizine can rather be recommended.

Neurology

Code in 1C

Name

Capsules 400 mg+25 mg

Residue storage unit

Pharmacotherapeutic group

Nootropic drug

Tradename

Combitropil®

International nonproprietary name

Piracetam + cinnarizine

Dosage form

Compound

per capsule: Active ingredients: cinnarizine - 25 mg, piracetam - 400 mg. Excipients: microcrystalline cellulose, lactose (milk sugar), magnesium stearate, talc. Composition of the gelatin capsule: titanium dioxide, methyl parahydroxybenzoate, propyl parahydroxybenzoate, acetic acid, gelatin.

ATX Code

Pharmacological properties

A combined drug with a pronounced antihypoxic, nootropic and vasodilating effect. Both components mutually potentiate their own antihypoxic effect and have a vasodilating effect. The combination drug also helps to significantly increase blood flow in the brain. The toxicity of the combination does not exceed the toxicity of the individual components of the drug. Piracetam is a nootropic drug. It has a positive effect on the metabolic processes of the brain: it increases the concentration of ATP in brain tissue, enhances the synthesis of RNA and phospholipids, stimulates glycolytic processes, and enhances glucose utilization. Improves the integrative activity of the brain, promotes memory consolidation, and facilitates the learning process. Changes the speed of propagation of excitation in the brain, improves microcirculation without having a vasodilating effect, and suppresses the aggregation of activated platelets. Has a protective effect against brain damage caused by hypoxia, intoxication, and electric shock; enhances alpha and beta activity, reduces delta activity on the EEG, reduces the severity vestibular nystagmus. Improves interneuronal transmission and synaptic conduction in neocortical structures, increases mental performance, improves cerebral blood flow. The effect develops gradually. It has virtually no sedative or psychostimulating effects. Cinnarizine is a selective blocker of slow calcium channels, reduces the entry of Ca2+ into cells and reduces its content in the plasma membrane depot, reduces the tone of the smooth muscles of arterioles, reduces their response to biogenic vasoconstrictors (epinephrine, norepinephrine, dopamine, angiotensin, vasopressin, serotonin). It has a vasodilating effect (especially in relation to cerebral vessels, enhancing the antihypoxic effect of piracetam), without having a significant effect on blood pressure. It exhibits moderate antihistamine activity, reduces the excitability of the vestibular apparatus, and lowers the tone of the sympathetic nervous system. In patients with impaired peripheral circulation, it improves blood supply to organs and tissues (including the myocardium), and enhances post-ischemic vasodilation. Increases the elasticity of red blood cell membranes, their ability to deform, and reduces blood viscosity.

Pharmacokinetics

The combined drug is quickly and completely absorbed from the gastrointestinal tract. Bioavailability of piracetam is 95%. Therapeutic effect appears after 1-6 hours. The maximum level of cinnarizine in plasma is observed after 1-4 hours, piracetam - after 2-6 hours. The metabolism of cinnarizine occurs entirely in the liver (by dealkylation). 60% of cinnarizine unchanged is excreted in the feces, the rest in the urine in the form of metabolites in about 5 hours. The maximum level of cinnarizine after 1-4 hours is noted not only in the blood, but also in the liver, kidneys, heart, lungs, spleen and brain. 91% bound to plasma proteins. Piracetam penetrates the blood-brain barrier and accumulates in brain tissue 1-4 hours after ingestion. It is eliminated from the cerebrospinal fluid much more slowly than from other tissues. Practically not metabolized. The half-life is 4.5 hours (7.7 hours from the brain). Excreted by the kidneys - 2/3 unchanged within 30 hours.

Indications for use

Cerebral circulation disorders: with atherosclerosis of cerebral vessels, ischemic stroke, the period of after-treatment after hemorrhagic stroke, after traumatic brain injury;
-encephalopathy of various origins;
-comatose and subcomatose states after intoxication and brain injuries;
- diseases of the central nervous system, accompanied by a decrease in intellectual and mental functions;
- labyrinthopathies of various origins: dizziness, tinnitus, nystagmus, nausea and vomiting;
- Meniere's syndrome;
-depression, psychoorganic syndrome with a predominance of signs of asthenia and adynamia, asthenia of psychogenic origin;
-prevention of migraine and kinetosis;
- memory impairment, mental function and concentration;
- lagging intellectual development in children.

Contraindications

Hypersensitivity, severe hepatic and/or renal failure, parkinsonism, pregnancy, lactation, childhood(up to 5 years).

Use during pregnancy

Contraindicated during pregnancy and lactation.

Directions for use and doses

Orally, adults - 1-2 capsules 3 times a day, for 1-3 months, depending on the severity of the disease; children over 5 years old - 1-2 capsules 1-2 times a day, for 1-3 months. Course of treatment 2-3 times a year. In case of chronic renal failure (creatinine clearance less than 60 ml/min), it is necessary to reduce the dose or increase the interval between taking the drug.

Side effect

Irritability, sleep disturbances, dyspepsia, headache, epigastric pain, dry mouth, allergic reactions ( skin rash), tremor of the limbs.

Every person today is familiar with the state of overwork. Attention is scattered, it becomes impossible to concentrate on the most simple things. Suddenly, memory begins to fail, tinnitus, insomnia, and irritability appear. Many people try to ignore these symptoms, thereby only aggravating the problem. But you shouldn’t neglect your health. Even young people, students and schoolchildren are advised to consult a doctor if such symptoms appear. Maybe, we're talking about about insufficient oxygen supply to the brain.

After the examination, the doctor will prescribe correct treatment. Most likely, among the drugs that support health will be Cinnarizine. Reviews from doctors about this medicine allow us to conclude that it is high efficiency. The drug has virtually no contraindications. It is prohibited only for nursing mothers and pregnant women. In all other cases, the medication "Cinnarizine", reviews not only from doctors, but also from people who have taken this medicine, allows you to quickly get rid of problems with weakened memory, attention, fatigue, and irritability.

Who is the medicine indicated for? The range of diagnoses for which the drug provides positive action, very wide.

The drug "Cinnarizine Sopharma" (named after the manufacturing company) activates cerebral and peripheral blood circulation. Having an increased affinity for certain brain cells, this medication improves impaired microcirculation and improves blood properties.

The drug "Cinarizine", the instructions indicate this, increases the resistance of cells to a lack of oxygen. It has an antihistamine and sedative effect, but does not depress cardiac activity. That is why the medicine “Cinnarizine”, reviews from experts do not disagree, is recommended for the following diseases and disorders:

• atherosclerosis;
• ischemia;
• dyscirculatory encephalopathy;
• post-traumatic states after head and skull injuries;
• dizziness, tinnitus;
• migraine;
• dementia of various origins;
• impaired memory, attention, thinking;
• loss of mental balance, emotional excitability or depression, fatigue;
• Raynaud's disease, Buerger's disease, other peripheral circulatory disorders;
• acroacinosis;
• trophic ulcers;
• diabetic angiopathy;
• prevention of labyrinth disorders.

The drug "Cinnarizine", reviews of only some patients noted this, can cause dry mouth, lungs dyspeptic disorders. Sometimes after taking the drug you may experience slight dizziness, headache or drowsiness. Extremely rare skin reactions: itching, lupus erythematosus. Even less common is tremors or weakening of the limbs.

It is recommended to take Cinnarizine after meals. Usually, to prevent circulatory disorders, up to 50 mg of medication, divided into several doses per day, is sufficient. To enhance peripheral blood circulation, the dose is increased to 70 mg.

The drug "Cinnarizine" has another excellent property: it prevents motion sickness and "sea sickness." It is enough to drink 25 mg of the drug half an hour before the trip, and you don’t have to worry about motion sickness. If the trip is very long, after 6 hours you can take a second tablet.

Don't forget that exact dosage The doctor selects the medications based on the patient’s characteristics. Self-administration of the medication may cause an overdose or cause other harm to the body.

Since the drug can cause some side effects (tremor, drowsiness, etc.), it should be used with caution by those people whose activities require fast response and special concentration.

"Cinnarizine": what does the drug help with? Instructions for use and reviews of the medicine

Briefly about the main thing

Cinnarizine is synthetic substance, a diphenylpiperazine derivative that acts as a blocker of L-type calcium channels and acts primarily on brain vessels. As an active active substance it is included in such drugs as:

• "Stugeron";
• "Vertizin";
• "Cinnarizine";
• "Cinedil";
• "Cinnarone";
• "Cinnasan."

All these drugs belong to the category antihistamines, produced mainly in tablets. Let's look at what Cinnarizine helps with.

Instructions for the drug

Before using any medicine, you must carefully read the instructions, which are usually found in the package along with the tablets. We suggest that you familiarize yourself with the features of using the drug “Cinnarizine”.

"Cinnarizine": indications for use

So, this drug is prescribed in the following cases:

• with atherosclerotic changes in the vessels of the brain;
• for recovery after ischemic stroke;
• for motor problems and vestibular disorders to eliminate symptoms such as dizziness, tinnitus;
• in the treatment of Meniere's disease;
• to eliminate symptoms of motion sickness.

How does the drug work?

The action of "Cinnarizine" is based on the ability active substance block cells from the entry of calcium ions into them, as a result of which cerebral microcirculation improves, and brain tissue is saturated with oxygen. This drug also has an antispasmodic effect and reduces blood clotting.

Cinnarizine works by blocking histamine and muscarinic receptors in the vomiting center of the brain, which prevents nerve messages from being received by the vestibular system.

Nerves located inside the ear send messages to the brain with information about movement. Along with messages from the eyes and muscles, these nerve impulses Help the body maintain a sense of balance. If the nerves from one ear send incorrect or changing information too frequently to the brain, messages sent from the other ear, from the eyes or from the muscles, conflict.

The brain begins to get confused with signals and this can cause dizziness, nausea and even vomiting. The person feels sick. "Cinnarizine" helps to cope with motion sickness and other problems associated with disturbances in the sense of balance.

Who should not take this medicine?

"Cinnarizine" has a number of contraindications for use. So, these tablets should not be taken in the following cases:

• children under five years of age;
• people with a rare hereditary blood pathology – porphyrin disease;
• pregnant or breastfeeding mothers;
• with intolerance to fructose, galactose, as well as lactase deficiency;
• in case of allergy to any of the ingredients of the drug;
• if you have prostate problems or difficulty urinating;
• in case of impaired functioning of the kidneys or liver;
• in the presence of pathologies such as glaucoma, epilepsy or Parkinson's disease.

Side effects

Medicines and related use side effects affect people differently. Below we list some known side effects from Cinnarizine:

• moderate drowsiness;
• weight gain with long-term use;
• stomach upset;
• nausea and vomiting;
• feeling lethargic;
• fatigue;
• abdominal pain;
• sweating;
• headache;
• dry mouth;
• skin reactions;
• tremors, twitching, stiffness of the arms, legs, face, neck, or tongue;
• jaundice.

Stop taking the drug and consult a doctor immediately if yellowing of the eyes or skin is noticed.

How to take Cinnarizine?

Before taking this medicine, read the manufacturer's printed information leaflet inside the package. This will give you more detailed information about the tablets and will provide full list diseases and conditions indicated for the use of Cinnarizine.

Take the drug only as prescribed by your doctor! Usually the doctor prescribes the following dosages:

• for impaired cerebral microcirculation - one 25 mg tablet three times throughout the day;
• in case of impaired peripheral circulation - two or three tablets of 25 mg three times a day;
• to prevent “travel sickness” you need to take 1 tablet before the trip no later than 1-2 hours;
• if expected long journey, you may take additional doses every eight hours as needed.

What are people saying?

In conclusion, for completeness, we suggest reader reviews about the action of “Cinnarizine”:

• Natasha: “I have stage 1 hypertension. Recommended in for preventive purposes"Cinnarizine." The expected effect did not come immediately, but it did not disappoint. I feel better, I feel less dizzy, and my memory has improved.”
• Elena: “I don’t know how it is for anyone, but with the help of these tablets I can only temporarily relieve symptoms, and then loud noise reappears in my ears. Conclusion: “Cinnarizine” is rather weak for treating my problem.”
• Luda: “Me and my girls a common problem- We don’t tolerate travel well. Motion sickness is a complete torment. They recommended Cinnarizin, and now I can’t go on long-distance transport without it. It helps very well against "travelers' sickness."

This article is purely informational. Please consult your doctor before using Cinnarizine tablets. Take care of yourself and be healthy!

"Cinnarizine" - instructions for use, reviews and release forms. Analogues of "Cinnarizine"

Many people who often suffer from headaches and vascular spasms are familiar with the medicine Cinnarizine. It is prescribed for any disorders of cerebral circulation or for high blood pressure. Although it has been used in medicine for several decades, Cinnarizine is still popular among doctors and patients. Despite the fact that the pharmaceutical industry now produces many vasodilators, none of them can compete with this drug either in price or in effectiveness. Those who have tried this medicine always have it in their medicine cabinet. There are also analogues of "Cinnarizine", but they are less common due to their higher price. The drug itself is available to anyone and effectively relieves vascular spasms, helps with any circulatory disorders and cerebrovascular diseases.

Why are these drugs important?

Not all people think about the importance of blood circulation. But it is the blood that carries oxygen to all cells and organs, which is important for their normal functioning. And when, for some reason, vasospasm occurs, the body reacts to this with pain. If measures are not taken immediately, the cells begin to die. This especially applies to the brain. Then it begins various disorders functioning of the nervous system and other organs. That's why it's so important to start drinking on time. vasodilators. For this purpose, Cinnarizine analogues and the drug itself are most suitable. They help restore blood flow and thereby relieve headaches, nausea, and are effective for memory and mood disorders.

Features of the drug

The drug "Cinnarizine" is a calcium channel blocker. Under its influence, the flow of calcium ions into cells is reduced. Because of this, the vessels become more elastic and the blood less viscous. The calcium content in the blood plasma also decreases, which also has a positive effect on the human condition. "Cinnarizine" also affects the smooth muscles of blood vessels. Under its influence the content increases carbon dioxide in the blood, which explains the vasodilatory effect. The drug also blocks the action of substances that constrict blood vessels. All this together has effective influence on a person’s well-being and helps with many diseases.

How does the medicine work?

Increases blood supply to the brain.

Relaxes the smooth muscles of the walls of blood vessels and dilates them.

Reduces blood viscosity and affects red blood cells, making them more elastic.

Improves the functioning of the vestibular apparatus.

Increases the resistance of tissues and muscles to oxygen deficiency.

Has a slight sedative and hypnotic effect.

Has a slight antihistamine effect.

"Cinnarizine" - indications for use

Any cerebrovascular accident.

Chronic cerebrovascular diseases.

Post-stroke condition.

Labyrinthine disorders - dizziness, tinnitus, nausea and nystagmus.

The recovery period after a traumatic brain injury.

Prevention and treatment of frequent migraine attacks.

Night cramps and cold extremities.

Complex treatment hypertension and vascular atherosclerosis.

Vascular complications in diabetes mellitus.

Peripheral circulatory disorders: thrombophlebitis, trophic ulcers, Raynaud's disease and others.

How else is the drug used?

Often, Cinnarizine is also prescribed as a prophylaxis for certain conditions. Its price is low: in pharmacies a package of the medicine costs no more than 30 rubles, so it is purchased even at relatively low prices. healthy people. It helps with frequent attacks migraines, motion sickness and seasickness. Thanks to its vasodilating and mild sedative effect, even one tablet of Cinnarizine can relieve attacks of panic and nausea. The drug is also used in cases of memory impairment and inability to concentrate. It has a good effect on mental activity, so sometimes schoolchildren and students are prescribed Cinnarizine. Its price is so low - 15-30 rubles per pack - that this allows you to take it long time, however, under the supervision of a doctor. They also drink it when there is increased irritability, constant bad mood. "Cinnarizine" is effective in the composition complex therapy for people prone to depression or susceptible to frequent stress. This drug helps improve blood supply to the brain, which has a positive effect on its functioning.

Can everyone drink Cinnarizine?

The drug is usually well tolerated, but there are conditions for which it is not recommended. In this case, the decision is made by the doctor and, perhaps, he will prescribe Cinnarizine analogues, which act more mildly. It is not recommended to take this drug for pregnant women and those who are breastfeeding. Cinnarizine is also prescribed with caution for liver and kidney dysfunction, Parkinson's disease, glaucoma and severe hypotension. It is accepted only in cases where the benefit from its action will be greater than the harm. And, of course, drink the drug when it appears allergic reactions It's also not worth it. It is not recommended for athletes to drink it, especially during competitions, since taking it may cause positive result during a doping test.

"Cinnarizine" for infants

This drug has been used in medicine for more than 60 years. It has also been used in pediatrics for a long time. Sometimes it is prescribed even to children under one year old. After all, there are such neurological diseases, which can only be cured during this period of life. Therefore, "Cinnarizine" is indispensable for infants with increased intracranial pressure, developmental delay, to dilate blood vessels and improve blood circulation in the brain. It is very important for such young children to make a correct diagnosis and start treatment on time so that irreversible changes do not begin. But many mothers are afraid to give their child Cinnarizine, because the instructions say that it is contraindicated for children under 5 years of age. But in some cases its effectiveness outweighs possible harm. In addition, doctors know how to properly prescribe such drugs to children. Usually give a quarter of a tablet 1-2 times a day. The course of treatment can last from several weeks to several months depending on the disease.

How to take the drug

Cinnarizine tablets are quickly absorbed in the intestines. It is recommended to take the drug after meals. And the dosage is calculated individually. Usually prescribed 1-2 tablets three times a day. In some cases, it is possible to take three medicines at a time. But daily dose should not exceed 9 tablets. For children, their number is halved. The effect of the medicine appears within half an hour after administration. And the process of drug metabolism lasts from 3 to 6 hours. Cinnarizine is excreted unchanged mainly through the intestines and partly through the kidneys. The drug is usually well tolerated, but in some cases side effects are possible. No special contraindications There is no drug to take except hypersensitivity, allergic reactions and pregnancy. But its overdose is dangerous. It is best to take Cinnarizine over a long course - up to three months, but in small doses. And in case of overdose it is possible sharp decline pressure and the onset of coma.

Side effects after taking the drug

Headache.

Lethargy and drowsiness.

Increased body weight.

Trembling of the limbs or their increased tone.

Intestinal disorder.

Abdominal pain.

Weakness and sweating.

Decreased blood pressure.

Allergic reactions.

Features of the medicine

This drug is available only in tablet form.

During treatment, it is contraindicated to take alcoholic drinks, since “Cinnarizine” accelerates the absorption of alcohol.

Long-term use of the drug is possible only if there is monitoring of the condition of the liver, kidneys and blood composition.

Cinnarizine tablets may cause drowsiness and inhibition of reaction, which should be taken into account when taken by people whose work involves driving vehicles and increased concentration attention.

The drug enhances the effect of certain medications, such as vasodilators, sedatives, or antidepressants.

The antihistamine effect of the drug may interfere proper implementation skin tests

What can replace the drug?

Many who have been prescribed this medicine are interested in what is better than Cinnarizine. They're probably embarrassed by this low price drug, and there is more trust in more expensive tablets. Now on sale there are both direct analogues of “Cinnarizine” and drugs with a different composition, but close to it in their effect.
The most common medications are Stugeron, Vertizin, Tsinedil and Cinnasan. These drugs are less popular, although they have the same composition and have the same effect. Why are analogues in less demand than Cinnarizine? Price most likely affects this primarily. Due to the fact that these drugs are produced at other enterprises, they cost from 100 to 200 rubles. Therefore, those who need a long course of treatment or prevention of certain conditions prefer to buy Cinnarizine. Sometimes in difficult cases To enhance the nootropic effect, drugs are prescribed that contain, in addition to this substance, others, for example, it is often combined with Piracetam.

What are the composition and release form of Piracetam + Cinnarizine?

The active compounds of the drug Piracetam + cinnarizine are presented the following substances: piracetam, the amount of which is 400 milligrams, as well as cinnarizine, its content is 25 mg.

Excipients of the drug: basic magnesium carbonate, nipazole, gelatin, calcium stearate, glycerol, purified water, in addition, sodium lauryl sulfate, as well as nipagin, titanium dioxide.

The drug Piracetam + Cinnarizine is available in hard gelatin capsules, the size of which corresponds to number zero, they are white, cylindrical in shape, and inside there is a fine whitish powder. One package contains 10 pieces. Dispensed by prescription.

What is the effect of Piracetam + Cinnarizine?

Piracetam is a nootropic drug intended to normalize cerebral vascular tone and stimulate the metabolism of nervous tissue.

Piracetam stimulates ATP synthesis reactions in brain cells, which increases resistance oxygen starvation(hypoxia) and accelerates the processes of recycling end products of metabolism.

The presence of this component in the pharmaceutical preparation helps to improve brain activity and is expressed in increasing the patient’s mental abilities, increasing cognitive abilities, eliminating negative consequences past brain diseases.

It is important to note that nootropic effect expressed only in the presence of changes in brain metabolism. There is practically no effect on the normal nervous system. In addition, the drug does not have a sedative or psychostimulant effect.

Cinnarizine is a calcium channel blocker that can inhibit the transport of calcium ions into the cell, which reduces the influence of vasoconstrictor factors. It is important to note that this substance causes almost no expansion peripheral vessels, acting selectively on circulatory system brain.

The action of cinnarizine is aimed at enhancing the antihypoxic properties of piracetam, which is intended to increase the resistance of nervous tissue to insufficient oxygen supply.

In addition, cinnarizine has little antihistamine effect which reduces the degree of excitability nerve cells vestibular apparatus, at the same time being a stimulator sympathetic division nervous system.

An additional factor that prevents the development of hypoxia is the ability of cinnarizine to improve the condition of erythrocyte membranes, which increases their elastic abilities and normalizes the rheological characteristics of blood.

Piracetam is not subject to biological transformation in the body. Upon entering the intestine, it is quickly absorbed into the bloodstream, which leads to the formation of an effective concentration. medicinal substance after 30 minutes. The half-life is 5 hours. Data on the pharmacodynamics of cinnarizine are not provided.

What are the indications for use of Piracetam + Cinnarizine?

Piracetam + cinnarizine capsules instructions for use allow use in medicinal purposes in the following cases:

Brain stroke and others vascular diseases nervous tissue during the recovery period;

Asthenic conditions;

Encephalopathy of various origins;

Toxic brain damage;

CNS (central nervous system) injuries;

Meniere's syndrome;

Prevention of kinetosis;

Lag in mental development in children;

Prevention of migraine attacks;

Any pathology of the nervous system that leads to a decrease in the patient’s mental abilities.

The drug Piracetam + cinnarizine should be prescribed by a specialist. Before use, you should visit your doctor.

What are the contraindications for use of Piracetam + Cinnarizine?

The instructions for use do not allow the use of the drug Piracetam + cinnarizine (capsules) in the following cases:

Kidney failure;

Pregnancy at any stage;

Hypersensitivity to the components of the drug;

Age 5 or less;

Severe liver pathology.

In addition, the lactation period.

What is the use of Piracetam + Cinnarizine? What is the dosage of Piracetam + Cinnarizine?

For adult patients, the drug is prescribed in the amount of 1 - 2 capsules 3 times a day, regardless of meals. The duration of treatment is about 3 months. In agreement with the doctor, as well as in the presence of positive dynamics, repetition is possible. treatment courses. Children are advised to take 1 – 2 capsules up to 2 times a day.

What are the side effects of Piracetam + Cinnarizine?

The use of the medicine may cause the development of the following side effects: headache, hallucinations, depression, nausea and vomiting, diarrhea, characteristic increased irritability, insomnia, decreased blood pressure, skin allergic manifestations and anaphylactic reactions, swelling, short-term increase in body temperature.

How to replace Piracetam + cinnarizine, what analogues should I use?

Phezam, Omaron, in addition, Combitropil, NooKam, as well as Piracezin (the instructions for use of each drug before use must be studied personally from the official annotation included in the package!).

Conclusion

Treatment of brain pathology must be carried out by adhering to a comprehensive regimen. First of all, you must strictly follow the doctor’s recommendations, regarding drug therapy. In addition, positive dynamics can be enhanced by rational nutrition, conducting vitaminization courses, good rest and restrictions labor activity. It is important to stop drinking alcohol and smoking.

Cinnarizine - analogues

The drug Cinnarizine- a medicine that is prescribed mainly for circulatory disorders in the brain. This is a drug that inhibits the penetration of calcium ions into the muscle cells of the heart and blood vessels from the intercellular space. This achieves dilation of the coronary arteries and peripheral arteries and arterioles, producing a vasodilating effect.

Some experts consider Cinnarizine to be outdated and prefer to prescribe for treatment its more modern analogues, which are similar in the mechanism of action and the achieved effects. Let's look at what analogues of Cinnarizine exist and what can replace this drug if necessary.

Cavinton or Cinnarizine - which is better?

Cavinton is a drug whose main component is vinpocetine. It has a neuroprotective and antioxidant effect, has a beneficial effect on blood circulation and metabolism in the brain, as well as on the rheological characteristics of the blood. Most often, this medicine is used for cerebral circulatory insufficiency accompanied by mental or neurological disorders.

Cavinton is similar in effect to Cinnarizine. However, at the same time, Cinnarizine has virtually no effect on blood pressure, which is valuable for the treatment of patients with blood pressure problems. Only a doctor can determine which drug is best to use, depending on the diagnosis and concomitant pathologies.

Cinnarizine or Vinpocetine – which is better?

Vinpocetine is used to correct cerebrovascular disorders. This is a natural preparation, the main ingredient of which is the alkaloid of the Vinca minor plant. The drug helps to increase blood supply to ischemic areas of the brain by relaxing vascular smooth muscle. The drug also has antiaggregation and antihypoxic effects.

Comparing the drugs Cinnarizine and Vinpocetine, it can be noted that the latter has fewer side effects and is made from plant materials. In addition, when treating with Vinpocetine, patients with liver and kidney diseases do not require a dosage reduction. However, some experts question the effectiveness of Vinpocetine.

Piracetam, Cinnarizine or Phezam - which is better?

Piracetam is a medicine belonging to the group of nootropic drugs. The mechanism of its action is not completely clear, but it is believed that the drug has a positive effect on metabolic processes and blood circulation in the brain, helps improve memory, attention, and mental activity.

Cinnarizine is not an analogue of Piracetam, but is often prescribed in combination with this drug. The combined use of these drugs gives a particularly high positive effect in chronic cerebrovascular insufficiency. Phezam is a medicine containing piracetam and cinnarizine as active ingredients.

Cinnarizine or Mexidol - which is better?

Mexidol is a drug based on ethylmethylhydroxypyridine succinate, which has antihypoxic, nootropic, anticonvulsant, anxiolytic effects, and increases the body's resistance to stress. It also improves blood circulation in the brain and has a positive effect on the rheological properties of blood. The drug appeared relatively recently, and its research is still ongoing. As a rule, it is prescribed not as a monotherapy drug, but in combination with other drugs, one of which may be Cinnarizine.

Vasobral or Cinnarizine – which is better?

Vasobral is a combination drug that is prescribed for cerebrovascular accidents. It contains two active ingredients: alphadihydroergocriptine (ergot derivative) and caffeine. The drug has an effect on the receptors of the central nervous system, helps reduce the permeability of vascular walls, thins the blood, improves blood circulation and metabolic processes in the brain. In addition, Vasobral has a preventive effect against migraines.

Comparing Cinnarizine and Vasobral, it is worth noting that the latter helps lower blood pressure, while Cinnarizine has almost no effect on it. Therefore, for hypotension, Cinnarizine can rather be recommended.

Can Cinnarizine be used by older people with high blood pressure and headaches?

As far as I remember, this drug can be taken even by children. At high blood pressure it is used systemically: 1-2 tablets 2-3 times a day for a month or even longer. But the exact dosage must be prescribed by a doctor. So do not self-medicate, consult a doctor!! !
Application: Cerebrovascular disorders: cerebral atherosclerosis, ischemic stroke, period after hemorrhagic stroke and traumatic brain injury, dyscirculatory encephalopathy; dizziness, tinnitus, depression and irritability, mental fatigue, migraine, senile dementia, decrease and loss of memory, impaired thinking and inability to concentrate; treatment and prevention of peripheral circulatory disorders (Raynaud's disease, obliterating atherosclerosis, thromboangiitis obliterans (Buerger's disease), diabetic angiopathy, acrocyanosis, intermittent claudication, trophic and varicose ulcers, paresthesia, cold extremities); maintenance therapy for symptoms of labyrinthine disorders, including dizziness, tinnitus, nystagmus, nausea and vomiting; prevention of kinetosis.
Directions for use and dosage: Orally, preferably after meals. Cerebrovascular accident: 25–50 mg 3 times a day, peripheral circulation disorder: 50–75 mg 3 times a day, imbalance: 25 mg 3 times a day, prevention of kinetosis: adults - 25 mg 30 minutes before travel, if necessary, again after 6 hours to the maximum recommended dose - 225 mg. Children are prescribed half the dose for adults. At high sensitivity for cinnarizir, treatment begins with 1/2 dose, increasing it gradually. Grapes benefits and harms

Preparations containing the combination of Piracetam + Cinnarizine:

Fezam - instructions for use. The drug is a prescription, the information is intended only for healthcare professionals!

Clinical and pharmacological group

A drug that improves blood circulation and brain metabolism.

pharmachologic effect

A combined drug with pronounced antihypoxic, nootropic and vasodilating effects. The components mutually potentiate a decrease in cerebral vascular resistance and help increase blood flow in them.

Piracetam is a nootropic drug. Activates metabolic processes in the brain by enhancing energy and protein metabolism, accelerating the utilization of glucose by cells and increasing their resistance to hypoxia. Improves interneuronal transmission to the central nervous system and regional blood flow in the ischemic area.

Cinnarizine is a selective blocker of slow calcium channels and an antagonist of histamine H1 receptors. It has been established that it inhibits the entry of calcium ions into cells and reduces their content in the plasma membrane depot. Reduces the tone of the smooth muscles of arterioles, reduces their response to biogenic vasoconstrictors (catecholamines, angiotensin and vasopressin). It has a vasodilating effect (especially in relation to cerebral vessels, enhancing the antihypoxic effect of piracetam), without having a significant effect on blood pressure. It exhibits moderate antihistamine activity, reduces the excitability of the vestibular apparatus, and increases the tone of the sympathetic nervous system. Increases the elasticity of red blood cell membranes, their ability to deform, and reduces blood viscosity.

Pharmacokinetics

Suction

After oral administration, the drug is completely absorbed from the gastrointestinal tract.

Cmax of piracetam in plasma is created after 2-6 hours. Bioavailability of piracetam is 100%.

Absorption of cinnarizine is slow. Cmax of cinnarizine in plasma is achieved after 1-4 hours.

Distribution

Piracetam does not bind to plasma proteins. The apparent Vd is about 0.6 l/kg. Piracetam freely penetrates the BBB. The maximum concentration of piracetam in the cerebrospinal fluid is achieved after 2-8 hours. Penetrates into all organs and tissues, penetrates the placental barrier. Selectively accumulates in the cerebral cortex, mainly in the frontal, parietal and occipital lobes, cerebellum and basal ganglia.

The binding of cinnarizine to plasma proteins is 91%.

Metabolism

Piracetam is not metabolized.

Cinnarizine is actively and completely metabolized in the liver by dealkylation with the participation of the CYP2D6 isoenzyme.

Removal

T1/2 of piracetam from blood plasma is 4-5 hours, from cerebrospinal fluid- 8.5 hours. 80-100% of piracetam is excreted unchanged by the kidneys by renal filtration. Renal clearance piracetam in healthy volunteers is 86 ml/min.

T1/2 of cinnarizine - 4 hours. 1/3 of the metabolites are excreted in the urine, 2/3 in the feces.

Pharmacokinetics in special clinical situations

T1/2 of piracetam is prolonged in renal failure. The pharmacokinetics of piracetam does not change in patients with liver failure. Penetrates through the filter membranes of hemodialysis machines.

Indications for use of the drug Fezam®

• cerebrovascular insufficiency (cerebral atherosclerosis, recovery period of ischemic and hemorrhagic strokes, after traumatic brain injury, encephalopathy of various origins);
• intoxication;
• diseases of the central nervous system, accompanied by a decrease in intellectual and mental functions (impaired memory, attention, mood);
• conditions after a traumatic brain injury;
• psychoorganic syndrome with a predominance of symptoms of asthenia and adynamia;
• asthenic syndrome of psychogenic origin;
• labyrinthopathy (dizziness, tinnitus, nausea, vomiting, nystagmus);
• Meniere's syndrome;
• prevention of kinetosis;
• migraine prevention;
• as part of complex therapy for low learning ability in children with psychoorganic syndrome.

Dosage regimen

For adults, the drug is prescribed 1-2 capsules 3 times a day for 1-3 months, depending on the severity of the disease. The course of treatment is 2-3 times a year.

Children over 5 years old are prescribed 1-2 capsules 1-2 times a day. The course of treatment is 1.5-3 months.

Side effect

From the nervous system: hyperkinesia, nervousness, drowsiness, depression; in isolated cases - dizziness, headaches, ataxia, imbalance, insomnia, confusion, agitation, anxiety, hallucinations.

Allergic reactions: very rarely - skin rash, dermatitis, itching, swelling, photosensitivity.

From the outside digestive system: V in some cases- increased salivation, nausea, vomiting, diarrhea, abdominal pain.

Other: increased sexual activity.

Contraindications to the use of the drug Fezam®

• severe renal failure (CK< 20 мл/мин);
• severe liver failure;
• psychomotor agitation at the time of drug prescription;
• Huntington's chorea;
• pregnancy;
• lactation period (breastfeeding);
• children under 5 years of age;
• hypersensitivity to the components of the drug.

The drug should be prescribed with caution in case of Parkinson's disease, impaired liver and/or kidney function, impaired hemostasis, and severe bleeding.

Use of the drug Fezam® during pregnancy and breastfeeding

Despite the lack of data on the presence of teratogenic effects of piracetam and cinnarizine, Phezam® is contraindicated for use during pregnancy.

Piracetam is released with breast milk, therefore, if necessary, use the drug during lactation breast-feeding should be stopped.

Use for liver dysfunction

Contraindicated in severe violations liver functions.

Use for renal impairment

Contraindicated in severe renal impairment.

Use in children

Contraindication: children under 5 years of age.

special instructions

Use with caution in patients with liver and/or kidney disease.

For renal mild insufficiency And medium degree severity (creatinine clearance less than 60 ml/min), the therapeutic dose should be reduced or the interval between doses of the drug should be increased.

In patients with impaired liver function, it is necessary to monitor the level of liver enzymes.

Patients should avoid drinking alcohol while taking Phezam.

The drug increases the activity of hormones thyroid gland and may cause tremors and restlessness.

Impact on the ability to drive vehicles and operate machinery

While taking Phezam®, patients should be careful when driving and operating machinery and equipment, since cinnarizine may cause drowsiness at the beginning of treatment.

Overdose

Phezam® is well tolerated by patients; in case of overdose, no serious side effects requiring discontinuation of the drug are observed.

Symptoms: possible abdominal pain.

Treatment: gastric lavage should be performed, induce vomiting; carrying out symptomatic therapy; if necessary, hemodialysis. There is no specific antidote.

Drug interactions

At simultaneous use with the drug Fezam® it is possible to enhance the sedative effect of drugs that depress the activity of the central nervous system, tricyclic antidepressants, as well as ethanol.

Phezam® potentiates the effect of nootropic and antihypertensive drugs.

When used simultaneously, vasodilators enhance the effect of the drug.

Phezam® improves the tolerability of antipsychotic drugs and tricyclic antidepressants.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored out of the reach of children, in a dry place, protected from light, at a temperature not exceeding 25°C. Shelf life - 3 years.