Drotaverine ampoules dosage. Features and limitations in the use of drotaverine in the form of injections. International nonproprietary name

Spasms and sharp pain are familiar to every person and in order to relieve the painful symptoms, painkillers are taken. More than half are antispasmodics, one of the most famous is Drotaverine.

Brief characteristics of Drotaverine

Belonging to the type of myotropic antispasmodics, Drotaverine has an effect on human body vasodilator effect. The active component in the drug is drotaverine hydrochloride, which has an antispasmodic effect on the smooth muscles of the gastrointestinal tract, of cardio-vascular system etc. The relaxation process is due to inactivation of the myosin kinase chain. Since the drug acts directly on smooth muscles, it is prescribed to patients who medical contraindications cannot use painkillers from the group of m-anticholinergics

The effect of the medicine is observed with spasms of both nervous and muscle origin.

Drotaverine helps very quickly: from the moment of administration, the process of complete absorption takes from 10 to 12 minutes.

The active substance is evenly distributed throughout the muscle tissue, the maximum concentration is two hours after use, while the analgesic and antispasmodic effect- in half an hour. Excretion from the body is carried out by the kidneys.

The medicine is available in the form of small round tablets of a yellowish-green hue. Typically one package contains from 10 to 50 pieces. You can purchase the product at any pharmacy; a prescription is not required.

Indications for use of Drotaverine

A wide range of symptoms for which drotaverine helps makes anti-spasm tablets common and popular with everyone age categories population. It can be drunk by both adults and children (from three years old), while the medicine does not affect concentration and attention, therefore it is allowed for use by persons driving.

The effect of the tablets is observed in the treatment of a large list of diseases and ailments:

Taking Drotaverine in combination with other medications should be done with caution. The drug enhances the effect of other antispasmodics, and also sharply lowers blood pressure if taken in combination with the use of antidepressants and quinidine.

Contraindications for use

Medical practice has proven that Drotaverine is well tolerated, and its use, especially of an episodic nature, is not accompanied by side effects. You cannot relieve spasms with this drug if you have diseases and symptoms:

Patients with glaucoma, atherosclerosis and arterial hypotension should take the medicine with caution. Since one of the auxiliary components is lactose, you should not take the tablets if you are lactose intolerant.

Children under three years of age should not use this product.

There are no clinical data to the required extent on the consequences of taking the drug during pregnancy. The prescription of tablets is carried out by a doctor based on an analysis of risks and expected benefits and effects.

Side effects from Drotaverine

In rare cases, side effects from the drug are observed:

There have been no cases of overdose of Drotaverine: the concentration of the active substance in the tablets is small, and the process of absorption and distribution in the blood occurs quickly.

Rules for taking pills

Occasional taking of tablets to relieve spasms during headaches does not require systematic treatment: it is enough to take one tablet. The effect occurs within half an hour and depends on general condition body.

Regular use of the drug should only be prescribed by the attending physician.

Complex therapy with Drotaverine consists of: regular intake medications for the period prescribed by the doctor. Daily dosage for adults is from 120 to 240 mg, it can be divided into 2-3 doses. The dose for a child over 6 years old is from 80 to 200 mg, for younger children - no more than 120 mg. One tablet can be divided into halves, and the frequency of use can be increased to 6 times a day.

The medicine is taken only orally, washed down big amount water. Eating does not affect the effect of the drug.

What is better Drotaverine or No-shpa?

If you experience pain, it is recommended to take the drug No-shpu - it has been known for many years and helps to quickly eliminate discomfort. But the price of the medicine is quite high - 64 rubles/6 tablets, 115 rubles/24 tablets. There is an analogue on sale - the drug Drotaverine, its cost is only 15 rubles / 20 tablets. Both drugs are also sold in solution for injection, and the price of Drotaverine also compares favorably.

Medicines have one active substance– drotaverine hydrochloride. The readings are also the same:

• gynecology – pain after operations, invasive procedures, threat of miscarriage, you can take pills with increased uterine tone during pregnancy;
• cardiology – vasospasm, headaches due to vasospasm, for moderate reduction in blood pressure;
• gastroenterology – intestinal colic, biliary colic, stomach pain;
• nephrology – renal colic due to stone movement.

The medications have a minimum of contraindications - they are not given to children under 2 years of age (although pediatricians often prescribe the drug by dividing the tablet into 2-4 parts). No-shpa and Drotaverine are also contraindicated in severe stages of renal and liver failure; during lactation they are taken once. The conclusion is: Drotaverine is complete structural analogue and generic original medicine, there is no significant difference between it and No-shpa, therefore the products are considered completely interchangeable. Their effectiveness, according to reviews, is also the same, and there is no need to overpay.

Other analogues of Drotaverine

Modern pharmaceuticals offer wide choose antispasmodics, including those based on the same active ingredients. It is no coincidence that many patients believe that noshpa and drotaverine are the same remedy. To relieve spasms, you can choose best option, suitable in composition, effect and cost.

Closest to Drotaverine in terms of chemical components and pharmacological action Papaverine, however, in terms of selectivity and selectivity of exposure is the first by 5 times more effective than analogue. This and others alternative means- first-stage antispasmodics. If the expected effect from taking is not observed, then it is worth moving on to treatment with second-stage antispasmodics.

This medication is a fairly effective drug that has an antispasmodic effect. What does Drotaverine help with? It has a beneficial effect on smooth muscle tissue various organs, eliminating spasm and pain of both muscular and nervous etiology. No significant side effects were noted with its use, however, this drug should be prescribed exclusively by a doctor.

This medicine is used for various diseases, which provoke the development of spasms, resulting in severe pain. This concerns mainly diseases of the vascular and digestive systems of the body.

Pharmacological action and composition of the drug

The medication is available in two main forms - as a solution for intramuscular injection and tablets "Drotaverine". The instructions indicate that the solution contains drotaverine hydrochloride and water for injection as the main components. The tablets of this medication also contain the main substance - drotaverine hydrochloride, and lactose as auxiliary substances, potato starch, talc, povidone, magnesium stearate.

The drug "Drotaverine" in tablets is prescribed somewhat more often than in injections. The active substance has antispasmodic activity and affects smooth muscles located in the biliary, genitourinary, cardiovascular and digestive systems, and also significantly dilates blood vessels. As a result, oxygen freely flows to tissues and organs and relieves spastic pain. Medicinal substances This medication can change the permeability of cell membranes in tissue and reduce the activity of the phosphodiesterase enzyme.

After taking the drug, the concentration in the blood of the main substance reaches a maximum after 40-60 minutes. The drug is excreted from the body in the urine, but a small amount is excreted through the intestines. Wherein pharmacological agent"Drotaverine" has practically no side effects in relation to cardiac, vascular and endocrine systems. It has antispasmodic, myotropic, vasodilating and hypotensive effects. So, why is Drotaverine prescribed?

Indications for use

Before prescribing a drug, the specialist should make sure that the patient does not suffer from hypersensitivity to the drug. The main indication for its use is to eliminate spastic pain of various origins, which can be caused by the following types of diseases:

• cholecystitis;
• stomach ulcer and duodenum;
• constipation, which is accompanied by spasms of intestinal smooth muscles;
• intestinal colic with increased gas formation;
• urethritis, cystitis;
• proctitis with severe pain;
• urethrolithiasis, nephrolithiasis, pyelitis.

In case of the above pathological phenomena, the drug is prescribed, as a rule, as an anesthetic drug, which is part of the complex therapy of the underlying disease.

What else does Drotaverine help with?

It is possible to use the drug during certain diagnostic procedures, for example, cholecystography. Elimination of spasms and pain is the main task of this medication. Since it has a vasodilating effect, medical specialists it is often prescribed to relieve severe headaches, which usually arise from spasms cerebral vessels in my head. Why Drotaverine is prescribed is of interest to many patients.

The drug is widely used in gynecological practice– it is able to eliminate spasms of the uterine pharynx, and is also used for prolonged dilatation. In addition, it is prescribed for emergency childbirth when the specialist notes the probability severe cramps in the uterus during the passage of the fetus. "Drotaverine" can be used for painful menstruation in women with various pathologies reproductive system.

Methods of application

According to the instructions, Drotaverine tablets should be taken orally and washed down with plenty of liquid. In this case, meal times, as a rule, do not have special significance. The medicine can be taken even on an empty stomach if a person suffers from severe colic, cephalgia or other manifestations of pain.

In cases where the pain is characterized by too much intensity, intramuscular injections of this medication are prescribed, since this method of its use involves more quick fix pain, which cannot be said about the tablet form of this drug - the tablets act only 40-60 minutes after administration.

With kidney or liver failure

For patients with renal or liver failure when using Drotaverine, exceptions are made - with such strong pain syndromes the medication can be administered intravenously (in small doses). However, the specialist should be very careful and monitor the patient’s condition, since there is a certain risk of collapse (decreased blood supply to tissues, as a result of which the functions of some systems and organs are disrupted). Therefore, similar medical procedures The patient should be performed exclusively in a supine position.

Course duration

It is not allowed to independently determine the duration of the course of therapy with this medication, since only a qualified doctor is able to determine the risks of developing side effects, correct dosage and evaluate the potential benefit of the drug.

Is it possible to inject Drotaverine into an artery?

IN in case of emergency When vasospasm occurs and peripheral circulatory functions are disrupted, it is possible to inject the medicine into the artery. The doctor carefully calculates the dose, and the medication should be administered even more slowly than intravenously. It should be noted because this procedure is an emergency, it should also only be carried out by a specialist who can eliminate possible Negative consequences when they occur.

Compatibility of the drug with other medications

If you combine the use of the drug "Drotaverine" with tricyclic antidepressants, then in these cases an increase in blood pressure. Morphine significantly reduces the spasmogenic effect of the drug. With everyone else pharmacological groups medical supplies"Drotaverine" interacts normally, that is, use in in this case other medications are not limited.

Side effects

In some cases, the following negative reactions may occur while taking the drug:

• violation digestive processes(changes in stool, dyspepsia);
• fainting, cephalgia, sleep disturbance;
• swelling of the mucous membranes, bronchospasm;
• Quincke's edema, excessive sweating, dermatitis;
• respiratory depression, atrioventricular block, hypotension;
• impaired passage of impulses into the ventricles from the atria, bradycardia.

Contraindications

As the instructions for use for Drotaverine tablets indicate, medication should not be used if you have the following pathologies:

• cardiogenic shock;
• malabsorption.
• heart failure of any type;
• low blood pressure;
• insufficiency of liver or kidney functions;
• atrioventricular blockade of II or III degree;
• Congenital lactase deficiency.
• atherosclerotic changes coronary arteries.
• obliterating atherosclerosis of the arteries of the lower extremities.

At what age is it allowed to take it?

Can children take Drotaverine? More on this later.

Drotaverine tablets are prescribed to children from the age of 3, and injections to children over 1 year of age. Age restrictions in the use of the tablet form are associated only with difficulties for children under 3 years of age in swallowing solid medicine. If a baby can swallow a pill, at age over a year old This form may also be used.

We have explained what “Drotaverin” helps with; we will further consider what patients think about it.

At any stage of pregnancy, a woman may experience spasm of smooth muscles and blood vessels. various reasons. This serious condition can cause miscarriage or premature birth, so there is a need for urgent use of specific medications. One of them is Drotaverine. During pregnancy, Drotaverine is rarely prescribed, but if the goal is to maintain the pregnancy, this drug becomes indispensable.

Most experts consider Drotaverine a relatively safe antispasmodic. The main effect of the drug is aimed at smooth muscles internal organs, while the nervous system does not suffer while taking it.

But Drotaverine has one significant drawback - this drug is not included in the international register of safe medicines. In addition, it has a completely synthetic composition, which increases possible risk negative impact for the fruit.

Characteristics of the drug

Drotaverine is an analgesic antispasmodic synthetic origin, which is an isoquinoline derivative. It affects the smooth muscles of the digestive, urinary, biliary, reproductive and vascular systems.

Indications for the use of Drotaverine are:

• migraine;
• cholecystitis and its complications;
• intestinal, renal or biliary colic;
• pyelitis;
• gastroduodenitis;
• biliary dyskinesia;
• colitis;
• spasm of the cervix during childbirth;
• contractions after childbirth;
• threat of miscarriage or;
• physiological childbirth and much more.

It should be noted that Drotaverine does not have negative influence on the functioning of the central nervous system and begins to act in the body from the first minutes of taking the drug. The first symptoms of improvement occur within 5 minutes after taking Drotaverine, and the desired effect can be achieved within 30 minutes.

Drotaverine is available in the form of tablets in dosages of 40 and 80 mg, as well as in the form of an injection solution. The cost of the drug varies from 16 to 80 rubles depending on the manufacturer.

Use during pregnancy

As mentioned above, Drotaverine should not be considered as an antispasmodic among expectant mothers, however, there is no data to prohibit this drug during pregnancy. This is due to the fact that the necessary laboratory research and scientific experiments.

But this drug was further studied by Hungarian specialists, who answered the question whether Drotaverine can be taken during pregnancy.

It turns out that it is possible if there is a need for this, since the drug itself does not have any effect. negative influence on the developing fetus and does not affect the course of pregnancy.

Gynecologists prescribe Drotaverine during pregnancy quite often and without success. Doctors say that the drug does a good job of removing increased tone uterine muscles and decreased spasms.

During birth process Drotaverine helps a woman give birth easier and endure painful contractions, and in postpartum period eliminate severe pain symptoms.

For pregnant women, Drotaverine is prescribed orally up to 6 tablets per day (up to 240 mg). The dosage of the drug directly depends on the pathology that has arisen. expectant mother and the severity of her condition.

In the 1st trimester, the drug is prescribed in tablet form. Starting from the 2nd and 3rd trimester, as well as during labor activity the drug is prescribed in the form of injections, which have a more pronounced therapeutic effect.

Indications for the use of Drotaverine during pregnancy are: aching pain in the abdominal area and increased uterine tone, due to which the fetus may experience and a threatening state of spontaneous miscarriage or early start childbirth

If the drug in tablet form turns out to be ineffective, experts resort to prescribing Drotaverine injections - 10 ml in the morning and evening. If the injections do not give the expected result, and the woman’s well-being remains the same, the doctor may increase the dosage; if this is ineffective, it becomes necessary to select a drug similar in action to Drotaverine.

Despite the whole list of advantages of this drug, it is not recommended to prescribe it to yourself and take it without the supervision of a doctor.

The doctor should tell the woman why Drotaverine is used during pregnancy - it is he who decides whether to take such a serious drug and what the dosage should be.

Contraindications and side effects

Drotaverine is contraindicated for the following problems:

• lactose intolerance;
• incomplete cardiac output syndrome;
• kidney or liver failure;
• individual intolerance to individual components of the drug;
• breast-feeding.

The list of contraindications, according to the instructions for Drotaverine, does not include pregnancy, but it must be taken into account that this drug is used during pregnancy as a means of preserving the fetus and normal course labor activity.

Use Drotaverine, especially on early stages, as a mild analgesic and antispasmodic, is prohibited.

TO side effects of the drug, especially if Drotaverine is used in injections during pregnancy, the following unpleasant complications include:

• insomnia;
• migraine;
• dizziness;
• nausea, vomiting;
• tachycardia;
• hypotension;
• increased sweating;
• individual intolerance to the drug;
• intestinal atony;
• feeling of heat.

From expectant mothers, reviews of Drotaverine as medicinal drug different. This remedy helped some women maintain desired pregnancy, get rid of increased uterine tone and find the happiness of motherhood, but for others this drug could not give the desired effect.

Perhaps the second group of women took Drotaverine without a doctor’s prescription. It is this circumstance that could influence the incorrect assessment of the effectiveness of the drug, since with an incorrectly selected dosage, the drug could have an inappropriate effect. healing effect or not give it at all.

What does drotaverine, an effective and often prescribed drug with an antispasmodic effect, help with? It has a beneficial effect on smooth muscle tissue various systems body, eliminating spasms and painful sensations both nervous and muscular etiology.

No serious side effects were noted, however, the drug should be prescribed exclusively by a doctor and taken by the patient under the supervision of a specialist.

Drotaverine: composition and pharmacological action

The drug is available in two dosage forms is a solution for intramuscular injections and tablets. The first includes:

• main component – ​​drotaverine hydrochloride;
• additional substances.

• drotaverine hydrochloride;
• lactose;
• additional components.

The drug is prescribed in tablet form more often than in injections.

After taking the drug, the active substance, which has antispasmodic activity, begins to affect smooth muscles, which are located in the genitourinary, biliary, cardiovascular and gastrointestinal tract. It significantly dilates the blood vessels, as a result of which oxygen begins to flow freely to the tissues and relieves spastic pain.

The components of the drug are capable of changing the permeability and potential of membranes in the tissue in a short period of time. They also reduce the activity of phosphodiesterase, a special enzyme.

After taking the tablet, the concentration of the active substance will reach its concentration in 50-60 minutes. Excreted from the body in urine, a small amount of may be excreted in feces.

At the same time, the drug Drotaverine does not have any serious side effects in relation to the cardiovascular system, comparing favorably in this regard with many of its analogues. It is a drug with antispasmodic, vasodilating, myotropic and hypotensive effects.

Indications for use

Why Drotaverine can be prescribed by a therapist - the specialist must exclude individual intolerance to the components of the drug. The main indication for its use is to relieve a person of spastic pain that can occur during the most various ailments. The drug may be prescribed if one of the following diseases has been diagnosed:

• frequent spasms with cholecystitis;
• stomach or duodenal ulcer;
• constipation, accompanied by spasms of smooth tissues that cause severe pain;
• colic due to gas retention;
• urethritis and cystitis;
• proctitis with pronounced pain;
• urethrolithiasis, pyelitis, nephrolithiasis - for these diseases, Drotaverine is prescribed as a local anesthetic drug, and it is part of a complex of medications.

Along with this, a medicine such as Drotaverine can be recommended for use when diagnostic activities. For example, with cholecystography or similar.

Elimination of spasms is the main task of Drotaverine

Because the drug has a vasodilating effect, health care providers often prescribe it to relieve severe headaches that occur when cerebral vasospasms occur.

The use of Drotaverine in gynecology is widespread - it can help with spasms of the uterine pharynx or with prolonged dilatation. It is also prescribed for emergency childbirth if the specialist notes the risk of uterine spasms during the passage of the fetus.

Taking Drotaverine

The tablets are taken orally and should be taken with plenty of water. The frequency of meals, as a rule, does not have any effect, so there is not much difference in taking Drotaverine before or after meals. You can even do it on an empty stomach if a person suffers from severe pain or colic. The only inconvenience in this case is that the impact on the source of discomfort may begin a little later.

If the patient suffers too much strong pain, which you have no strength to endure, the doctor may prescribe injections. They act much faster because they are administered intramuscularly. However, for patients with hepatic or renal colic There are exceptions - in them the drug is administered intravenously (slowly and in small portions). At the same time, there is a small risk of collapse (decreased blood supply to tissues, resulting in dysfunction of certain organs), so such procedures should be carried out exclusively in a supine state.

Important: it is prohibited to independently determine the duration of the course; only a specialist can choose how to take Drotaverine.

In particularly emergency cases, when vasospasm occurs and peripheral circulation is disrupted, Drotaverine can even be injected into an artery. The dosage must be carefully calculated by the doctor, and the drug should be administered even more slowly than intravenously.

Important: since the procedure is emergency, it should only be performed by a specialist. He can stop possible consequences(although, as a rule, with proper actions medical worker they do not appear).

Compatibility of the drug with other drugs

If you use Drotaverine for the abdomen or in other cases in combination with other drugs that also have an antispasmodic effect, the effect of treatment may be enhanced, but such therapy should be carried out exclusively with the approval of the attending physician. Only a specialist will recommend medications that not only do not cancel therapeutic effect Drotaverine, but can also make it more pronounced.

If you combine Drotaverine with tricyclic antidepressants, you should be prepared for the fact that arterial hypotension can intensify many times over.

Patients who have been prescribed morphine should use Drotaverine with caution, as this drug greatly reduces the spasmogenic effect.

Overdose of Drotaverine

It is strictly forbidden to change the dosage prescribed by your doctor. An increase in the number of tablets or injections can provoke the development of atrioventricular block and lead to paralysis of the respiratory nerve, and the consequences of this can be extremely negative.

Possible side effects

Side effects from taking Drotaverine can occur in two cases: if it is taken for too long or if allergic reaction to any component. Such actions include the following manifestations:

• gastrointestinal tract - belching, constipation (or vice versa diarrhea), feeling of nausea, vomiting;
• central nervous system – fainting, severe headaches, disrupted daily routine, sleep disturbances;
• respiratory tract – swelling of the mucous membranes or bronchospasms;
• allergic reactions – angioedema, dermatitis, rash, excessive secretion sweat, itching;

All the described effects occur both when taking tablets and after injections, but in the latter case the patient may begin to develop depressed breathing, hypotension, or atrioventricular block (impaired conduction of electrical impulses from the atria to the ventricles).

It is important to observe the dosage of the drug, in otherwise side effects may occur

If you have headaches while taking Drotaverine or one of these side effects has been noted, and especially after injections, then the course of treatment should be stopped and you should consult your doctor. He will be able to either select analogues or prescribe additional medications to eliminate these actions.

Use during pregnancy and lactation

Drotaverine hydrochloride, the active substance, is able to penetrate the hematoplacental barrier. In other words, this component of the drug can have a direct effect on the fetus and in one way or another influence its development. A specialist may prescribe the drug if the hypothetical benefit for the pregnant woman is higher than potential threat for a child.

During breastfeeding you should stop taking Drotaverine, since it gets into mother's milk and, accordingly, is transmitted to the baby. If refusal is impossible, then you need to think about temporarily stopping breastfeeding and transferring the child to artificial formula.

Often, medication may be prescribed during premature birth, to relieve the tone of the uterus (this will stabilize the condition if there is a threat of miscarriage and will help promptly and without harm to the mother’s health to begin all the necessary auxiliary actions), as well as in the period after childbirth to stop contractions.

Whether Drotaverine can be prescribed to children is an open question. Some pediatricians and therapists are against therapy using this medicine and strongly recommend using it only after reaching 12 years of age, while others believe that the drug will not cause harm and prescribe it from 5-6 years of age. In any case, the treatment process with this medicine should be carried out under constant monitoring attending physician.

Contraindications for use

As a rule, almost all medicines have certain contraindications, and Drotaverine is no exception. It should be used only after reading the instructions and according to the prescribed course of treatment. Contraindications are identical regardless of which form of the drug was chosen. These include:

• heart failure;
• cardiogenic shock;
• low blood pressure;
• atrioventricular block II or III degree;
• renal or liver failure;
• congenital lactase deficiency;
• malabsorption.

Drotaverine injection solution Drotaverine pro injectionibus

international and chemical name: drotaverine, 1 – (3,4 – diethoxy-benzyl) 6,7 – diethoxy – 3,4 – dihydro – isoquinolone hydrochloride;

Basic physical and chemical characteristics: transparent solution from almost colorless to pale yellow with a greenish tint, without mechanical inclusions.

Compound. 1 ml of solution includes 20 mg of drotaverine hydrochloride;

other ingredients: absolute alcohol, sodium edetate, sodium metabisulfite, sodium sulfite, water for injection.

Release form of the medicine. Injection.

Pharmacotherapeutic group. Synthetic antispasmodics and anticholinergic blockers.

ATS A03A D02.

Pharmacological properties:

Pharmacodynamics. Drotaverine is an antispasmodic with myotropic action. Reduces the tone of smooth muscles of internal organs, reduces their motor activity, moderately dilates blood vessels. It is superior to papaverine in terms of intensity and duration of antispasmodic action. Has no effect on the vegetative nervous system and CNS. Acts directly on smooth muscle muscles and can be used as an antispasmodic in cases where use is contraindicated medicines from the group of anticholinergic drugs (glaucoma, prostate hypertrophy). When administered intravenously, the effect of the drug is observed after 2 - 4 minutes. The maximum effect develops after 30 minutes;

· pharmacokinetics. Distribution. Drotaverine does not penetrate the blood-brain barrier. Metabolism. Drotaverine hydrochloride is biotransformed in the liver. Selection. The half-life of drotaverine is 16 hours. Excreted in the form of metabolites, 50% is excreted in urine and 30% in feces.

Indications for use. Renal colic; hepatic colic, hypermotor dyskinesia of the biliary tract and gallbladder; intestinal colic, pylorospasm, peptic ulcer stomach and duodenum in the acute phase (as part of complex therapy); spasms of peripheral arteries, spasms of cerebral vessels; algodismenorrhea. Drotaverine is also used to reduce the excitability of the uterus during pregnancy and during certain instrumental studies and cholecystography.

Method of use and dose. The dose is set individually. In adults, it is used intramuscularly, intravenously and subcutaneously at 40-80 mg 1-3 times a day. For hepatic and renal colic, it is recommended to use 40-80 mg intravenously slowly.

For spasms of peripheral arteries, Drotaverine can be used intra-arterially.

In children under 6 years of age, a single dose is 10-20 mg, the maximum daily dose– 120 mg; aged 6-12 years, a single dose is 20 mg, the maximum daily dose is 200 mg. Apply 1-2 times a day.

Side effect. From the cardiovascular system: possible palpitations, feeling of heat; at intravenous administration There was a decrease in blood pressure (before collapse), the development of AV blockade.

From the respiratory system: with intravenous administration, cases of inhibition of the respiratory center have been observed.

Others: possible dizziness, increased sweating.

Contraindications. Hypersensitivity to the components of the drug; renal, hepatic or .

Interaction with other drugs. At simultaneous use drotaverine may reduce the antiparkinsonian effect.

Overdose. Symptoms: in case of overdose, the symptoms described in the “Side Effects” section may increase.

Treatment: symptomatic.

Features of use. Use with caution in patients with severe atherosclerosis of the coronary arteries. Drotaverine can be used as part of combination therapy to relieve a hypertensive crisis.

Pregnancy and lactation. If necessary, during pregnancy and breastfeeding, Drotaverine should be used with caution and only when possible benefit for the woman outweighs the potential risk to the fetus.

Storage conditions and periods.

Store in a dry place, protected from light and out of reach of children, at a temperature of 15°C-25°C.

Shelf life – 2 years.