Ambrobene drops for inhalation instructions for use. "Ambrobene" for inhalation: indications. What diseases can be cured using ambrobene in liquid form

In diseases of the bronchi, which must be treated with mucolytic agents for sputum discharge, Ambrobene is prescribed for inhalation with saline either in the form of syrup or tablets.

The most effective is the method of introducing the drug into the respiratory tract through a nebulizer. It is suitable for therapeutic manipulations for adults and children.

Description of the drug: abstract

Ambrobene solution for nebulizer may have a light yellow tint, odorless. Can tablets be used for inhalation? This is not necessary, since the finished liquid product does not require additional procedures, except dilution bodily fluid.

The active substance of the mucolytic agent is ambroxol hydrochloride. It promotes expectoration, improves the drainage of pathological secretions and its formation. The impact begins half an hour after the introduction, healing effect lasts six to twelve hours.

According to studies, it is known that stimulation of the secretory cells of the respiratory organs begins from ambroxol, and a secret begins to secrete abundantly from the glands of the mucosa.

Thus, thick sputum is liquefied, the ciliated epithelium moves it up, and mucolicytic transport improves.

The solution has an antioxidant effect. And when simultaneous treatment antibiotics, enhances their antiseptic effect by increasing the concentration of antibacterial components directly in the mucous secretion.

What cough is prescribed Ambroxol hydrochloride?

Inflammatory processes in the bronchi and lungs, which are accompanied by thick, difficult to expectorate mucus;
Obstructive bronchitis with spasms and dry cough;
Bronchial asthma with asthma attacks (but bronchodilators are given first to exclude bronchospasm);
Bronchiectasis with sputum congestion and purulent exudate in sacs;
With laryngitis, colds, SARS;
Pneumonia.

Inhalations with Ambrobene in a nebulizer give a quick positive effect because the drug does not pass through the gastrointestinal tract, blood vessels and tissues, and immediately penetrates to the site of inflammation and pathological condition.

What kind of cough shows inhalation with Ambrobene?

The main purpose of the active ingredient - Therefore, it is recommended in cases where the patient inflammatory processes in the respiratory organs are accompanied by the formation of thick mucus.

What helps Ambroxol hydrochloride? Its action is aimed at thinning the exudate and stimulating the functionality of the secretory glands.

So it helps to remove the pathological secret from bronchial tree and alveoli. Therefore, the substance helps with dry and wet cough. Let's try to understand their differences:

Dry cough. Intrusive, defiant pain V chest, differs in the paroxysmal nature of the course, for example, with tracheitis.

Wet. Accompanied by increased expectoration of a thick secret. It may be white or yellowish green infectious lesion mucous membrane.

Many parents ask is it possible to give ambroxol with a dry cough if the child does not expectorate anything anyway. Of course yes. The sooner the mucus begins to move away, the faster the patient will recover. Exudate drainage relieves respiratory organs from bacteria, viruses, stagnant viscous secretion.

How to do inhalation with Ambrobene: instructions

The mucolytic composition for inhalation is different the minimum amount side effects. Therefore, it can be used at home. But newborn babies should be under the supervision of a pediatrician.

At what age can the medicinal substance be sprayed? The instructions indicate that it is suitable for the treatment of even infants. It is important to consider that it is used exclusively in nebulizer inhalers.

How to dilute Ambrobene for inhalation with saline? It is diluted in a ratio of 1:1, regardless of how old the patient is. The exact dosage of the drug for one procedure is selected by the doctor. The procedure is not carried out without saline solution.
Source: website In order to make a solution, use the usual saline solution (sodium chloride), which is sold in a pharmacy. It is sterile and suitable for therapy infectious diseases. Self-made saline liquid will not meet the requirements.

How long to do inhalation? Nebulizer spray should generally last 5-15 minutes. The duration of inhalation depends on the age of the patient and the amount of medication infused into the container of the device. Children are advised to inhale the aerosol for no longer than 5 minutes. And for adults, the time is extended to 15 minutes.

Before carrying out the manipulation, the liquid must be heated to body temperature so as not to overcool the respiratory organs with sprayed particles. How exactly to warm it up, the doctor can advise.

Adults and children over 6 years old

Aerosol with saline and mucolytic must be administered correctly so as not to cause complications and symptoms of drug overdose. What method of application is recommended from the age of six?

The diluted solution (4 ml) is poured into the container. Keep the proportions one to one. 2 ml of medicine and 2 ml of saline are added to the container.

The duration of one procedure should not exceed 10 minutes. Small patients are advised to inhale the aerosol for 5 minutes.

The mixture is diluted before each manipulation. The procedure is repeated 3 times a day, depending on the doctor's prescriptions.

It is important to follow the rules for inhalation through a nebulizer. They are not made immediately after a meal. You need to wait an hour and a half after eating and only after that start treatment.

The exact dose of the infused medication is measured with a measuring cup, which comes with the bottle.

Dosage for children aged 2 to 6 years

Ambroxol hydrochloride is safely used by patients from the age of two in the regimen calm breathing using a nebulizer. It can be compressor or ultrasound machine but not steam.

How to make a solution for young children? Only 2 ml is required for one procedure liquid composition. The dilution ratio with saline is 1:1. Take sodium chloride 0.9%.

After that, the liquid is heated to body temperature, for example, by holding the vial in the hand. The child should not inhale deeply, so as not to cough from a sharp ingress of aerosol into the respiratory tract. The duration of a single therapy is 3-5 minutes.

Ambrobene inhalation syrup should be used no more than 2 times a day. If children from two to six years old have bronchial asthma, then they are given bronchodilators before the procedure. They prevent spasm of the airways.

How many days are children usually treated with this mucolytic drug? Five to seven days. But, if the child recovers faster, then the therapy is canceled a little earlier.

Children under 2 years old and infants

Inhalation with Ambrobene and saline can be prescribed even to the smallest patients. But newborns are allowed to carry out procedures only under the supervision of a pediatrician. Accurate dosage established by a specialist, self-treatment can lead to dangerous consequences.

What does the aerosol taste like? It has neither smell nor taste, therefore it is suitable for curing children from birth.

One procedure requires take one milliliter of ambroxol hydrochloride and the same volume of saline. Physiology is repeated twice a day. If, after manipulation, the cough intensified and sputum began to leave, this is very good.

But, since babies still do not know how to expectorate mucus, inhalation is done 3 hours before bedtime. And the child’s pillow should be high so that the mucus does not accumulate in the respiratory organs, but normally stands out.

Sometimes newborns are prescribed Berodual and Ambrobene together in order to achieve the fastest result of treatment. This is especially true in the development of bronchial asthma.

After completing the course of physiatry, inhalations can be carried out with mineral water, for example, Borjomi. It has a softening and moisturizing effect, helps to normalize the drainage of mucus.

During pregnancy

On this moment no confirmed clinical research, which would give an unambiguous answer whether it is possible to prescribe ambroxol hydrochloride to pregnant women. In the first and second trimester, only a doctor can decide whether to prescribe a medication or choose another, safer one.

The composition of the mucolytic drug is absorbed through the placental barrier and excreted along with breast milk. This should be taken into account in the treatment of pregnant and lactating mothers.

The same condition applies to the lactation period, because active ingredient excreted in breast milk. Whether there will be a risk for the baby, it is impossible to say for sure.

Contraindications and side effects

Inhalation is prohibited for people with the following pathologies:

Impaired functionality of the muscles of the bronchus, in which the evacuation of the secret is difficult;
Serious liver disease;
Mucus hypersecretion.

Very rarely, patients experience side effects. Possible temporary dry mouth, vomiting, pain in the gastrointestinal tract. If symptoms persist, therapy is discontinued.

Overdose in the form of signs of intoxication was not observed. But from a large amount of a substance, pressure can decrease, salivation will increase. There is nausea as well as vomiting. Sometimes appear allergic reactions.

Analogues are cheaper: what can be replaced?

A cheap drug that has a mucolytic effect is Ambroxol. He great substitute Ambrobene because it contains the same active ingredient. Also suitable:

Ambrohexal
Lazolvan
Flavamed
Neo-Bronchol
Mukosolvan, etc.

Questions to the doctor

It is not uncommon for patients to have additional questions about inhaling a mucolytic drug. Let's try to answer them.

Is it possible to do procedures at a temperature?

The instructions for nebulizers say that at 37.5 0 C and above, it is better to refrain from inhalation. But sometimes they are carried out even at a temperature of 38 0 C. The doctor will tell you exactly.

Can it be diluted with water?

No. Only physiological fluid, which has a composition similar to the chemical compounds of blood. Separately, it is recommended to spray mineral alkaline water.

What else can be diluted?

Only sodium chloride 0.9%, aka saline. Other thinners are not suitable.

Is it possible to drink Ambrobene and do inhalations with it at the same time?

The instructions indicate that if you use 2 forms of release, the healing process is accelerated. Doctors recommend using the syrup at the same time for internal reception.

How many drops does an adult patient need for oral treatment, says the expert. It is very important not to exceed daily dose medicines.

Is it possible to combine

This drug has an anti-inflammatory, antimicrobial, thinning effect. It is prescribed for the same inflammation as ambroxol hydrochloride. But the expediency of a simultaneous combination should be established individually.

How much does ambrobene cost: price

Release form	Package	Manufacturer	Price in Russia	Price in Ukraine
Syrup 15 mg/5 ml, 100 ml		Thewa, Germany	130 rub.	UAH 58.65
Solution 7.5 mg/ml dropper bottle 100 ml		Thewa, Germany	190 rub.	UAH 85.71
Solution 7.5 mg/ml dropper bottle 40 ml		Thewa, Germany	from 130 rub.	from 58.65 UAH

The basis of the drug Ambrobene is the active substance ambroxol. In composition, it belongs to the group of benzylamines and is a metabolite of bromhexine. But, unlike bromhexine, this substance does not have a methyl group, but there is a hydroxyl group. Ambroxol has a secretolytic, secretomotor and expectorant effect. Ambrobene begins his therapeutic effect half an hour after ingestion. Tablets, solution and syrups continue to act for a period of 6 to 12 hours, depending on the amount of medication taken. Long-acting capsules have a therapeutic effect for 24 hours.

If Ambrobene is introduced into the body with the help of injections, then it quickly penetrates into the tissues. Subsequently, part of the administered drug is concentrated in the lungs. When taken internally, the medicine enters the body through the gastrointestinal tract.

Composition and form of release

chief active substance this medicine is Ambroxol, which stimulates serous cells located in the glands of the bronchial mucosa. Under its action, cells are activated in the ciliated epithelium, as a result, the viscosity of sputum decreases. Ultimately, the mucociliary effect improves. Ambroxol has antioxidant properties. When used in conjunction with antibiotics, it increases their concentration in bronchial secretions and sputum.

Ambroxol tablets, the active substance ambroxol hydrochloride is contained in an amount of 30 mg per tablet. In addition to hydrochloride, they contain corn starch, lactose monohydrate, magnesium stearate and silicon dioxide.

In capsules prolonged action amount active substance ambroxol hydrochloride contains 75 mg per capsule. Auxiliary substances are also present here. These are MCC (RN 102 and RS 581), methacrylic acid, hypromellose, ethyl acrylate copolymer and anhydrous colloidal silicon dioxide, triethyl citrate. The capsule is made of gelatin. The composition of the cap includes gelatin, iron dyes - yellow, black and red oxides, titanium dioxide.

Syrup contains in its composition the active substance ambroxol hydrochloride 0.3 grams per 100 ml. As auxiliary elements, there are 70% liquid sorbitol, raspberry flavor, propylene glycol, saccharin and purified water.

In solution for inhalation and internal intake there is 0.75 grams of ambroxol hydrochloride for every 100 ml. In addition, it contains a number of additional substances. 0.1 grams of potassium sorbate, 0.06 grams of 25% hydrochloric acid and 99.19 grams of purified water.

Solution for intravenous administration contains 15 mg of ambroxol hydrochloride for every 2 ml. Additionally contains substances such as monohydrate citric acid- 1.8 mg, sodium chloride - 13.6 mg, sodium hydrogen phosphate heptahydrate - 4.7 mg and 1979.9 mg of water for injection.

Indications for use

Contraindications

Despite the high medicinal qualities, the drug Ambrobene has contraindications. It is not recommended to use in cases of hypersensitivity of the body to ambroxol or to any excipient. It is strictly forbidden to use all types of medicine for pregnant women during the 1st trimester.

Additional restrictions exist for tablets. Do not take children under six years of age and with glucose-galactose malabsorption or lactose intolerance. Prolonged-release capsules are not recommended for children under the age of twelve. The syrup is contraindicated in patients with fructose intolerance.

Carefully take Ambrobene should be when the motor function of the bronchi is impaired and with increased sputum formation due to the syndrome of immobile cilia. Oral dosage forms contraindicated during periods of exacerbations peptic ulcer stomach and duodenum. Be careful when using Ambrobene in the 2nd-3rd trimester of pregnancy and during the lactation period.

Take special care with impaired renal function or serious illnesses liver. In these cases, reduce the dose of Ambrobene and increase the time intervals between doses of the drug.

Use during pregnancy and lactation

Despite the absence of explicit prohibitions, it is not recommended to take Ambrobene for women in the 1st trimester of pregnancy. During the 2nd and 3rd trimester, the use of the drug is allowed only under medical supervision in order to avoid possible pathological changes in the body of the unborn child.

It is not recommended to use Ambrobene while breastfeeding. The possibility of ambroxol penetration into mother's milk. Therefore, there is a possibility of causing some harm to the body of a newborn baby. In such cases, in agreement with the doctor, appoint similar medications or funds from the arsenal of traditional medicine.

Side effects

As a result of taking tablets, syrup, capsules of prolonged action Ambrobene, there are general violations 0.1 - 1% of drug use. This is manifested by allergic reactions in the form skin rash, urticaria, itching, shortness of breath, angioedema of the face. Sometimes, negative reactions manifested by headache, weakness, fever, up to anaphylactic shock.

Rarely there are malfunctions gastrointestinal tract during which abdominal pain, nausea, vomiting, constipation or diarrhea occur. Sometimes, after taking Ambrobene, there is a feeling of dryness in respiratory tract and oral cavity.

When using Ambrobene in the form of a solution for inhalation and oral administration, certain side effects are also observed. The immune system in 1% of cases reacts with hypersensitivity or anaphylactic reactions. The nervous system in 10% of cases is characterized by impaired taste perception. The functions of the gastrointestinal tract are disturbed in 10% of cases, as well as while taking other types of Ambrobene.

Dosage and administration

The drug Ambrobene is used orally, by inhalation or intravenous administration. The duration of the course of treatment is determined on an individual basis, depending on the severity of the disease. Taking Ambrobene on your own, without a doctor's prescription, should not last more than 4-5 days. Strengthening the mucolytic effect of Ambrobene occurs with the use of liquid in large quantities.

Pills taken orally, after a meal. They are swallowed without chewing. Drinking tablets, you need to use as much liquid as possible.

Children 6-12 years old take half a tablet 2-3 times a day. For children over 12 years of age and adults, the daily dose is 3 tablets in the first 2-3 days of the course of treatment. Then, the drug Ambrobene is taken twice a day, one tablet. Reinforcement if needed therapeutic effect, the daily dose for adults may be increased to four tablets.

Capsules prolonged action are taken orally in the same way as tablets. Daily dose for children after 12 years and adults is one capsule or 75 mg of ambroxol.

Syrup taken orally, after a meal. The required dose is determined using the measuring cup included in the preparation. The daily children's dose is: up to 2 years - 0.5 cups, 2 times; 2-6 years - 0.5 cups, 3 times; 6-12 years - 1 cup 2-3 times a day.

Adults and children after 12 years of age take Ambrobene syrup as follows: during the first 2-3 days of therapy in the amount of 2 measuring cups three times a day. In case of low effect of therapy, the daily dose for adults is increased to 4 cups. At normal course diseases, the dose of the drug is reduced to two cups taken twice a day.

When severe cough haunts, interferes with work and rest, so you want to find a medicine that will quickly cope with the problem. A challenge within the power German drug helping to weaken unpleasant symptoms to alleviate the condition. It is important to read the instructions so that the use does not cause harm.

Active ingredients Ambrobene

The drug is characterized by mucolytic properties. After application, it begins to develop a large number of mucus, which is immediately excreted from the nasopharynx, lungs, bronchi. Instruction Ambrobene informs that the drug normalizes, facilitates breathing, has the following properties:

anti-inflammatory;
antioxidant;
expectorants.

Ambrobene - instructions for use are known - has an effectiveness due to the properties of the drug. With the start of admission:

clumping of small alveoli is excluded;
improves patency in small bronchi;
the movement of the cilia of the epithelium is stimulated, their gluing is excluded, which contributes to the removal of mucus;
enzymes are produced that thin sputum, reduce viscosity;
increased production of immunoglobulin local immunity;
harmful bacteria are removed.

The composition of the drug Ambrobene, according to the instructions, depends on the release format - capsules, solution, tablets, but everywhere it contains the main substance - ambroxol hydrochloride. Auxiliary ingredients can be:

magnesium stearate;
silicon dioxide;
corn starch;
potassium sorbate;
liquid sorbitol;
hydrochloric water;
propylene glycol;
saccharin;
raspberry flavor.

Indications for the use of a mucolytic agent, which has a low cost, are respiratory diseases. Their feature is the presence of difficult-to-separate, viscous sputum. Treatable:

tracheobronchitis;
pneumonia;
bronchiectasis;
nasopharyngitis;
bronchitis;
sinusitis;
laryngitis;
pneumoconiosis;
cystic fibrosis of the lungs.

Effective use of a cheap drug to improve the patient's condition:

dry cold cough during SARS,
to clear the bronchi surgical intervention, after holding;
in order to stimulate the maturation of the lungs in a child in perinatal period;
at bronchial asthma if there is a problem with sputum discharge;
to facilitate the excretion of mucus in tuberculosis.

How to use Ambrobene

An important condition, according to the instructions, is when drinking the drug big amount water - at least 100 ml: this helps better liquefaction and excretion of mucus. The prescribed dosage must be observed. How to take Ambrobene - depends on the release format:

solution - dilute with juice, water;
tablet, syrup - drink;
composition for inhalation - breathe;
effervescent tablets- dissolve in water.

Ambrobene syrup - instructions for use

The children's form of release of medicine is very convenient. Ambrobene syrup has pleasant taste raspberries, does not contain thickeners, preservatives - it is safe for the child. Produced in dark bottles of 100 ml, 5 ml contains 15 mg of ambroxol. For ease of use, there is a measuring cup. The pediatrician prescribes a dosage depending on age:

under 5 years old - 2.5 ml per day 2-3 times;
from 5 to 12 - 5 ml three times a day;
after 12 years - 10 ml, 3 times a day.

Solution for oral and inhalation - instructions

The medicine used in liquid form acts faster. The drug is in a dark 100 ml dropper bottle, equipped with a glass with divisions - it is convenient to dial the right dose. For adults at one time 4 ml, for children - 2 ml, according to the instructions, it is recommended to use three times a day. Ambrobene for inhalation is used in dosages selected by the doctor. If asthma is present, bronchodilators are taken first.

Inhalations for children

With a dry cough, you can quickly alleviate the child's condition by inhaling with a nebulizer. The solution in the form of fine drops gets to the most remote parts of the bronchi and lungs, moisturizing, softening the mucosa, improving expectoration. How to do inhalations with Ambrobene? The process goes like this:

liquid medicine mix equal parts with saline;
fill in a container;
breathe freely for 3 minutes;
course - up to 7 days.

Pills

For oral use, tablets produced in the usual and effervescent form are popular, as well as gelatin capsules for affordable price. Drink them after meals, be sure to drink water. Use the medicine in different ways:

Ambrobene tablets contain 30 mg of ambroxol and require three times a day;
the capsule has a prolonged action, it contains 75 mg of the active substance - this dose is enough for a day.

Application of Ambrobene

Describes in detail how to drink Ambrobene, what to focus on, instructions for the drug. The following points are important:

the effect of the treatment comes in half an hour, the action lasts 12 hours;
use of the drug for up to 2 years exclusively as prescribed by the pediatrician;
with simultaneous practice with antibiotics, their effect is enhanced;
it is undesirable to use without medical supervision for more than 5 days.

When a cough with sputum difficult to separate appears, it is better if the doctor prescribes the dosage, taking into account contraindications, the form of release of the drug, and writes out the treatment regimen. Need to know:

you should stop taking the drug in the formation of side effects;
exclude simultaneous consumption with antitussives;
mandatory drinking of the medicine with water is required.

What cough to take

The instructions for use indicate the effect of this drug in the treatment inflammatory diseases respiratory organs. What kind of cough give Ambrobene? Good reviews from doctors have the use of the drug in the presence of viscous, hard-to-remove sputum. The drug helps quickly:

liquefy mucus;
remove it from the body;
improve breathing.

No less effective treatment for dry cough. Application medicinal solution in the form of inhalation by adults, children contributes to the appearance of sputum. There is an improvement in well-being when the mucus begins to separate. The cough becomes wet, soft, which alleviates the condition in case of diseases:

catarrhal tracheitis;
pneumonia;
chronic bronchitis.

Contraindications of the drug

Although the medicine can be purchased without a prescription and at an affordable price, it is advisable that the doctor prescribe the remedy taking into account the state of health - there are contraindications to Ambrobene's use. Among them - hypersensitivity to the main active substance - ambroxol, as well as:

violation of bronchial motility;
taking antitussive drugs;
breastfeeding period.

Annotation Ambrobene stipulates unwanted use medicines in the form of capsules for a child under 12 years of age. Its use is contraindicated when significant secretions are observed, in addition, in the case of:

liver diseases;
epilepsy;
first trimester of pregnancy;
impaired renal function;
ulcers of the duodenum, stomach.

Ambrobene side effects

Because there are many good reviews about the drug, and the price is low, there is a desire to use it in self-treatment. The instruction does not recommend this - with the wrong dosage, uncontrolled long-term use, side effects of Ambrobene are not excluded. Possible appearance:

reduced pressure;
allergic dermatitis;
nausea;
diarrhea;
dry mouth;
itching;
constipation
vomiting;
urticaria;
increased salivation;
heartburn;
chills
high temperature;
headache;
angioedema;
anaphylactic shock.

Price

In Russia, the most popular drug is manufactured by the German company Meckle GmbH, which can be bought inexpensively at the nearest pharmacy. Capsules, syrup, solution, tablets are sold without a prescription. Alternatively, you can order from an online pharmacy. How much does Ambrobene cost? average price depends on the issue format, trading conditions and is in rubles:

solution, 100 ml - 165 rubles;
capsules, 75 mg, No. 20 - 260 rubles;
syrup, 100 ml - 130 rubles;
tablets, 30 mg, No. 20 - 125 rubles.

Video

Ambrobene - antitussive medicine mucolytic (promoting sputum thinning) action. Renders positive impact to the lungs in the prenatal period.

Pharmacological action of Ambrobene

The active ingredient in Ambrobene is ambroxol hydrochloride. chemical compound, which has a pronounced effect on glandular cells bronchi and alveoli of the lungs. Reduces the viscosity of sputum (mucolytic action) by stimulating its secretion during increased secretion surfactant - a surfactant contained in the lungs and bronchi with the normalization of serous and mucosal, that is, liquid and viscous components of sputum. It affects the mobility of the cilia of the ciliated epithelium lining the respiratory tract, accelerating the movement of sputum outward (secretory effect).

In the prenatal (antenatal) period, it has a stimulating effect on the development of the lungs, increasing the production and release of surfactant, while preventing its decay. This action is associated with the use of Ambrobene to prevent lung failure in children born prematurely.

Release form and analogues

The drug Ambrobene is available in the following dosage forms:

Tablets - 30 mg of active ingredient each, in a package of 20 pcs.;
Capsules containing 75 mg of ambroxol hydrochloride, 10 and 20 pcs. packaged;
Solution for oral and inhalation Ambrobene, with an active substance content of 7.5 mg per 1 ml, in vials of 40 and 100 ml;
Solution for injection, also containing 7.5 mg of ambroxol per 1 ml of the drug, in ampoules of 2 ml, in a package of 5 pcs.;
Ambrobene syrup, with an active substance content of 5 mg per 1 ml, in 100 ml vials.

Analogues of Ambrobene with the same active ingredient in the composition are drugs: Lazolvan, Ambroxol, Ambrosan, Medovent, Ambrohexal, Ambrolan, Ambrosol, Deflegmin, Bronchorus, Bronchoxol, Mucobron, Neo-bronchol, Suprima-cof, Fervex for cough, Flavamed, Halixol.

Indications for use Ambrobene

In accordance with the instructions, Ambrobene is effective in diseases of the respiratory tract, accompanied by sputum with increased viscosity. These include:

Acute bronchitis;
Chronical bronchitis;
Bronchial asthma;
Chronic obstructive pulmonary disease;
bronchiectasis.

Also, this drug is used in obstetric practice to stimulate the maturation of the lungs, if necessary, artificial childbirth ahead of schedule or the existing threat of independent premature birth in the period of 28-34 weeks of pregnancy. This use of Ambrobene is effective prevention respiratory distress syndrome, often developing in premature babies due to the unwillingness of the lungs to perform their functions.

Dosage and scheme of application of Ambrobene

According to the instructions, Ambrobene is shown in the following dosages:

Adults and children over 12 years old: 1 tablet 3 times a day for the first 3 days, then 1 tablet 2 times a day, or ½ tablet 3 times a day until the cough subsides;

Ambrobene capsules take 1 capsule 1 time per day.

Parenteral: injection of 1 ampoule 2-3 times a day for adults, in severe condition, doubling the dosage is possible. For children, the dose for parenteral administration is calculated as 1.2-1.6 mg of ambroxol hydrochloride per 1 kg of body weight.

A solution for oral administration and inhalation Ambrobene is taken according to the scheme:

Adults, as well as children over 12 years old, 4 ml 3 r. per day for the first 3 days, then 4 ml 2 p. per day, or 2 ml 3 r. per day;

Up to 2 years, 1 ml 2 r. per day;

2-5 years 1 ml 3 r. per day;

5-12 years 2 ml 2-3 r. per day.

Ambrobene for inhalation is used as follows:

Adults, as well as children over 5 years old, 1-2 inhalations per day, 2 (children) -3 (adults) ml of solution;

Children under 5 years old - 1 inhalation per day, 2 ml of solution.

Syrup Ambrobene:

Adults and children over 12 years old 10 ml 3 times a day for the first 3 days of illness, then 10 ml 2 times a day or 5 ml 3 times a day;

up to 2 years, 2.5 ml 2 p. per day;

2-5 years 2.5 ml 3 r. per day;

5-12 years old, 5 ml of Ambrobene syrup 2-3 r. per day.

Treatment of pulmonary insufficiency in the prenatal period is carried out according to the scheme: 10 mg of ambroxol hydrochloride per 1 kg of body weight per day, divided into 3-4 parenteral administration. Maximum allowable dosage when serious condition the child is 30 mg of ambroxol hydrochloride per 1 kg of body weight per day, it must also be divided into 3-4 injections.

Contraindications to the use of Ambrobene

The use of Ambrobene is contraindicated in the following situations:

Individual intolerance to ambroxol hydrochloride;
Ulcerative diseases of the gastrointestinal tract;
1 trimester of pregnancy;
breastfeeding period.

Unwanted Effects

When the dosage is observed in accordance with the instructions, Ambrobene, as a rule, is well tolerated, its administration rarely leads to side effects. However, in clinical practice The following side effects have been reported with its use:

From the side immune system: delayed and delayed allergic reactions immediate types(urticaria, exanthema, angioedema, anaphylactic shock);
On the part of the respiratory tract - shortness of breath, a feeling of dryness in the respiratory tract, rhinorrhea;
From the urinary organs - dysuria;
From the side nervous system- headache;
From the side digestive tract – dyspeptic phenomena different intensity(nausea, vomiting, diarrhea, pain in the epigastric region);
From the side of cardio-vascular system- lowering blood pressure;
Miscellaneous - fever, chills, dry mouth.

special instructions

Ambrobene may interact with others medicinal substances that should be taken into account in complex therapy. Pharmacologically incompatible with medications having an alkaline reaction, their combined use is unacceptable due to possible neutralization (Ambrobene solution has an acid reaction).

Do not use simultaneously with other antitussive drugs due to a decrease in the therapeutic effect.

The effect of the use of Ambrobene is enhanced against the background plentiful drink, therefore, during therapy with this drug, it is necessary to observe drinking regimen With high content liquids.

Conditions and terms of storage of Ambrobene

Store in sealed packaging out of direct access. sun rays, in a place inaccessible to children with an air temperature not exceeding 25 ° C.

Under these conditions, the shelf life of all forms of the drug is 5 years.

It is possible to leave Ambrobene without a doctor's prescription.

1 ml of the drug contains

active substance: ambroxol hydrochloride 7.5 mg,

Excipients: potassium sorbate, hydrochloric acid 25% (for pH correction), purified water

Description

Clear, colorless to slightly yellowish-brown solution.

Pharmacotherapeutic group

Medicines to relieve the symptoms of colds and coughs. Expectorants. Mucolytics. Ambroxol.

ATX code R05CB06

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pharmachologic effect

Pharmacokinetics

Suction. Absorption is high and almost complete, linearly dependent on the therapeutic dose. The maximum plasma concentration is reached within 1-2.5 hours.

Distribution. Distribution is rapid and extensive, with highest concentrations in lung tissue. The volume of distribution is approximately 552 liters. Communication with blood plasma proteins is approximately 90%.

Metabolism and excretion. Approximately 30% of an oral dose undergoes a "first pass" effect through the liver.

CYP3A4 is the main enzyme responsible for the metabolism of ambroxol, under the action of which, mainly in the liver, conjugates are formed.

The half-life is 10 hours. Total clearance: within 660 ml / min, renal clearance makes up 83% of the total clearance. Excreted by the kidneys: 26% in the form of conjugates, 6% in free form.

Excretion decreases with impaired liver function, which leads to an increase in plasma levels by 1.3-2 times, but does not require dose adjustment.

Gender and age do not have a clinically significant effect on the pharmacokinetics of ambroxol and do not require dose adjustment.

Eating does not affect the bioavailability of ambroxol hydrochloride.

Pharmacodynamics

Ambrobene® has a secretolytic and expectorant effect; stimulates the serous cells of the glands of the bronchial mucosa, increases the content of the mucous secretion and the release of a surfactant (surfactant) in the alveoli and bronchi; normalizes the disturbed ratio of serous and mucous components of sputum. By activating hydrolyzing enzymes and increasing the release of lysosomes from Clara cells, it reduces the viscosity of sputum. Raises motor activity cilia of the ciliated epithelium, increases the mucociliary transport of sputum. Increased secretion and mucociliary clearance improves sputum separation and relieves cough.

It has been proven that the local anesthetic effect of ambroxol is due to dose-dependent blockade sodium channels neurons. Under the influence of ambroxol, the release of cytokines from the blood, as well as from tissue mononuclear cells and polymorphonuclear cells, is significantly reduced.

Clinical studies on patients with sore throat have shown a significant reduction in pain and redness in the throat.

Indications for use

Secretolytic therapy for acute and chronic bronchopulmonary diseases characterized by impaired secretion and difficult sputum discharge

Dosage and administration

Ambrobene® oral and inhalation solution is dosed using the supplied dosing cup. Take after a meal with a sufficient amount of warm liquid, such as tea or broth:

Adults and children over 12 years old: in the first 2-3 days, 4 ml 3 times a day (equivalent to 90 mg of ambroxol per day), then 4 ml 2 times (equivalent to 60 mg of ambroxol per day).

Children from 6 to 12 years old: 2 ml 2-3 times a day (equivalent to 30-45 mg of ambroxol per day).

Children from 2-5 years old: 1 ml 3 times a day (equivalent to 22.5 mg ambroxol per day).

The duration of treatment depends on the characteristics of the course of the disease. It is not recommended to use Ambrobene® without medical prescription for more than 4-5 days.

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Side effects

Gastrointestinal Disorders

Often (≥ 1/100 -< 1/10):

Nausea, taste changes, decreased sensation in the mouth and throat (oral and pharyngeal hypoesthesia)

Uncommon (≥ 1/1000 -< 1/100):

Vomiting, diarrhea, dyspepsia, abdominal pain, dry mouth

Rare (≥ 1/10000 -< 1/1000):

Dry throat

Immune system disorders

Unknown:

Anaphylactic reactions, including anaphylactic shock

Skin and subcutaneous tissue disorders

Rare (≥ 1/10000 -< 1/1000):

Rash, hives

Unknown:

Itching and other hypersensitivity reactions, angioedema.

Contraindications

Hypersensitivity to ambroxol and / or other components of the drug

severe liver failure

severe kidney failure

I trimester of pregnancy

Children's age up to 2 years

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drug interaction

No clinically significant adverse drug interactions have been reported.

Combined use with antitussive drugs leads to difficulty in sputum discharge against the background of cough suppression.

Increases the penetration and concentration in the bronchial secretion of amoxicillin, cefuroxime and erythromycin.

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special instructions

Registered very rare cases severe skin lesions such as Stevens-Johnson syndrome and toxic epidermal necrolysis, when using ambroxol hydrochloride. They are mainly due to the severity of the underlying disease and concomitant treatment. In addition, on early stage Stevens-Johnson syndrome and toxic epidermal necrolysis, patients may show signs of the onset of a non-specific disease, with the following symptoms: fever, pain throughout the body, rhinitis, cough and sore throat. The appearance of these symptoms may lead to unnecessary symptomatic treatment anti-cold drugs. In case of occurrence skin lesions- the patient is immediately examined by a doctor, the use of ambroxol hydrochloride is stopped.

When limiting the functional ability of the kidneys and / or with severe liver disease, Ambrobene® should be used with extreme caution, reducing the dose used and increasing the time between doses of the drug.

Pregnancy and lactation

Ambroxol hydrochloride crosses the placental barrier. Preclinical studies have not shown direct or indirect negative effects on pregnancy, fetal development, childbirth and postnatal development.

It is not recommended to use Ambrobene® during the first trimester of pregnancy. Although there is no reliable data to date negative influence on the fetus and infants, the use of the drug in II and III trimesters pregnancy and lactation is possible after a careful analysis of the benefit / risk ratio by the attending physician.