Picamilon: exact dosage and indications for use. Picamilon: instructions for use and what it is needed for, price, reviews, analogues

Picamilon is a drug belonging to the pharmacological group of nootropics and cerebral circulation correctors, which has anti-migraine, improves cerebral circulation, tranquilizing, nootropic, antioxidant, anti-aggregation effects.

Active ingredient: Nicotinoyl gamma-aminobutyric acid

Release form: tablets for oral administration, solution for injection (for intramuscular or intravenous administration).

The drug is considered one of the best nootropics prescribed to relieve anxiety, enhance mental performance and induce anti-aging effects. Reviews from patients often describe picamilon as a drug that can provide an involuntary calm feeling. These statements make sense considering that the product was created by combining GABA and niacin. Picamilon injections are prescribed along with the use of tablets.

The chemical structure of picamilon 4-(pyridine-3-carbonylamino)butanoic acid, or nicotinyl chloride-gamma-aminobutyric acid, was developed in 1969 by the All-Union Vitamin Research Institute in the Soviet Union. The drug is widely used in Russia for various medical purposes - maintenance therapy after stroke, treatment of depression, asthenia, and various types of glaucoma. Most patients interested in using nootropics choose picamilon to boost mood, cognitive energy and focus, relieve stress, and improve brain health.

Officially, picamilon is used for the following pathological conditions and disorders:

• alcohol dependence syndrome;
• withdrawal state;
• other non-organic psychotic disorders;
• depressive episode;
• migraine;
• cerebrovascular syndromes in cerebrovascular diseases;
• disorders of the autonomic nervous system;
• primary open-angle glaucoma;
• cerebral infarction;
• consequences of cerebrovascular diseases;
• intracranial injury;
• toxic effect of alcohol.

Pharmacological action of the drug

Niacin, also known as vitamin B3, or niacin. This is a vitamin that is found in various foods such as liver, fish, beef and chicken. Niacin deficiency is not very common in developed countries due to its ample presence in diets. However, some patients require increased amounts of niacin due to its positive effects on cholesterol levels and blood vessel health. As part of picamilon, niacin plays two very important roles:

• It is a powerful vasodilator.
• It has the ability to cross the blood-brain barrier and take GABA with it.

GABA - gamma-aminobutyric acid, is the main inhibitory neurotransmitter in the central nervous system. Thus, if you increase GABA levels in the brain, the result will be a calming effect. This can lead to reduced stress and anxiety. The problem is that supplementing solely with pure GABA is not very effective because the substance cannot cross the blood-brain barrier. However, GABA can be produced directly in the brain through the conversion of glutamate. However, a much more efficient and effective method would be to be able to directly transport the acid with a carrier that is able to cross the blood-brain barrier.

Picamilon is transported across the blood-brain barrier via a specialized niacin analogue pathway. Afterwards, the components of the drug are hydrolyzed - interact with water, and are broken down into the neurotransmitter GABA and niacin. Hence the effects produced by picamilon, which are more characteristic of high levels of GABA and niacin. GABA is considered an inhibitory neurotransmitter, promoting the brain's ability to relax and prevent excessive stimulation. These effects are described as an anxiolytic effect that can reduce the negative effects of anxiety and tension of various etiologies and genesis.

Many patients experience a calm and easily concentrating state of mind when taking GABAergic supplements, which is what picamilon essentially is. Patients may also experience a decrease in inhibitions, which can be especially helpful in treating social anxiety. In addition, picamilon can help eliminate repetitive intrusive thoughts or so-called background noise in the brain, which can disrupt the way you think and make it difficult to concentrate for long periods of time.

As a precursor to niacin, picamilon can also increase energy levels and overall neuronal resistance. Nicotinic acid is part of the vitamin complex and has a number of functions both in the nervous system and the gastrointestinal tract. The primary cognitive effect of niacin lies in its similarity to a cerebral vasodilator - the drug is able to increase cerebral circulation. By providing neurons with more oxygen, glucose and other nutrients, picamilon, with the help of niacin, can lead to higher levels of alertness, greater concentration and mental endurance.

In general, with the use of the drug, brain function improves, since increased blood flow in the cerebral vascular bed can actually lead to more active energy metabolism in brain cells. In addition, picamilon has a detoxifying effect on neurons - better blood flow means more flushing out of toxins that form very quickly in the brain, especially after drinking large quantities of alcohol.

Benefits of Picamilon

The benefits of picamilon are reliable for those patients who suffer from anxiety, depression, sleep disorders or other mood disorders. Picamilon is also very useful for occasional nootropic applications where the patient's goal is to increase mental energy while simultaneously suppressing high levels of anxiety. Taking picamilon can provide a feeling of well-being as well as increased motivation to act.

Many people use picamilon, which can help them overcome social anxiety or shyness, since the drug can eliminate some fear and improve the development and adaptation of verbal skills in society.

It is worth noting that this nootropic is most often used compared to phenibut, which is also a GABA-derived drug that provides anti-anxiety effects. However, the big difference between the two drugs is that phenibut is quite sedative, while picamilon is energizing. If the choice between these two drugs is a matter for the patient, then to make the choice easier, picamilon is best used during the day and phenibut at night to help improve nighttime sleep.

Side effects of picamilon

Picamilon is well tolerated by the vast majority of people, but in some rare cases it is known to cause allergies in the form of skin rashes. Other side effects tend to be milder, such as dizziness, headache, nausea, irritability, low blood pressure and erythematous redness of the skin. There have been no reported cases of overdose, but the patient should never exceed the recommended dosage as this may significantly increase any potential risk of side effects. Before using picamilon, you should check with your doctor about possible combined use of the drug with any other medications or anti-anxiety supplements, especially those based on other compounds, but affecting GABA receptors.

The proposed dosage range of picamilon has been significantly expanded depending on the individual needs and purposes of using this drug. If a patient takes picamilon as an underlying mood enhancer and energy support, positive results are possible even with the smallest dosages. To eliminate anxiety and relieve stress, the dose is usually doubled.

Picamilon is considered safe for daily use, but if used regularly, it is recommended to periodically break the drug cycle to ensure that the patient has not developed tolerance to the effects of nootropics.

Picamilon should also not be prescribed if the patient has kidney disease or risk factors associated with stroke.

Picamilon is contraindicated in combination with medications for the treatment of mood disorders such as benzodiazepines.

Interestingly, some patient surveys report that picamilon works better for improving mood than some other medications previously prescribed. However, you should always consult your doctor before starting to use picamilon, especially for pregnant and breastfeeding women. Using picamilon in small doses to improve mood can be very effective, but when used as a standard medical treatment for complex medical conditions, it can have serious consequences.

Picamilon (N-nicotinoyl-gamma-aminobutyric acid sodium salt) is a nootropic drug. In recent years, the scope of use of nootropics in medicine has expanded significantly: these drugs are in demand in psychiatry, neurology, narcology, geriatrics, and pediatrics. They are successfully used for disorders of cognitive functions (memory, attention, concentration, mental activity), for the rehabilitation of patients suffering from cerebrovascular accidents, chronic alcoholism, etc. One of the most prescribed nootropics is Picamilon. This drug was synthesized in 1969 at the All-Union Vitamin Research Institute, and it has been used in medicine since 1986. It is a derivative of nicotinic and gamma-aminobutyric (GABA) acids. Nicotinic acid is an active participant in the processes of cellular respiration, has a vasodilating, antihypoxic, antiplatelet effect, facilitates the penetration of the drug through the blood-brain barrier (GABA itself lacks this ability), and enhances the neurometabolic and neuroprotective effects of GABA. Picamilon has a positive effect on metabolic processes and blood flow in the cerebral cortex, and stimulates blood circulation in the coronary arteries. In terms of power and duration of cerebrovascular action, the drug is significantly superior to the substances from which it is synthesized - nicotinic acid and GABA. In the fast pace of life dictated by the harsh reality of recent decades, Picamilon will be useful to a wide range of people: sick and healthy, young and old.

One of its most important qualities is the ability to quickly return reduced physical and mental performance to its previous level. The use of Picamilon for fatigue is widespread in absolutely healthy people who, due to increased stress load, require adequate pharmacological support. Picamilon makes it possible to reduce dosages or completely abandon prescribed medications. It combines well with other drugs in complex treatment algorithms for various diseases. Picamilon provides high compliance, has a positive safety profile, and exhibits virtually no clinically significant side effects, which allows it to be prescribed to women during pregnancy and breastfeeding, as well as used in pediatric practice. The drug reduces the increased vascular tone of the carotid and vertebral arteries, increases the intensity of cerebral blood flow, incl. in ischemic areas, has a protective effect on neurons of the cerebral cortex, protecting them from the aggressive effects of free radicals and oxygen starvation, and improves the lipid profile. Has a mild tranquilizing effect. It is not addictive and does not exhibit a muscle relaxant effect. Well tolerated by patients during a course of treatment.

Pharmacology

Nootropic drug, dilates blood vessels in the brain. It also has a tranquilizing, psychostimulating, antiplatelet and antioxidant effect. Improves the functional state of the brain by normalizing tissue metabolism and influencing cerebral circulation (increases the volumetric and linear velocity of cerebral blood flow, reduces cerebral vascular resistance, suppresses platelet aggregation, improves microcirculation).

When taken as a course, it increases physical and mental performance, reduces headaches, improves memory, and normalizes sleep; helps reduce or eliminate feelings of anxiety, tension, fear; improves the condition of patients with motor and speech disorders.

Pharmacokinetics

Release form

2 ml - ampoules (10) - cardboard packs.
2 ml - ampoules (10) - contour cell packaging (1) - cardboard packs.
2 ml - ampoules (10) - contour cell packaging (2) - cardboard packs.
2 ml - ampoules (5) - contour cell packaging (2) - cardboard packs.
2 ml - ampoules (5) - contour cell packaging (1) - cardboard packs.

Dosage

Take orally, regardless of food intake.

For cerebrovascular diseases, a single dose is 20-50 mg 2-3 times a day, a daily dose is 60-150 mg. The course of treatment is 1-2 months. Repeated course - after 5-6 months.

Depressive states of late age: 40-200 mg/day for 2-3 doses, the optimal dose range is 60-120 mg/day for 1.5-3 months. As an antiasthenic and anxiolytic agent - 40-80 mg/day, if necessary - up to 200-300 mg/day, for 1-1.5 months.

For alcoholism during the abstinence period, a dose of 100-150 mg/day is prescribed, for a short course of 6-7 days; for more persistent disorders outside of abstinence - 40-60 mg/day for 4-5 weeks.

To restore performance and under increased loads - 60-80 mg/day for 1-1.5 months, for athletes at the same dose for 2 weeks. training period.

Parenterally administered intravenously, drip or stream (slowly), intramuscularly.

For chronic cerebrovascular accidents - IV or IM, 100-200 mg, 1-2 times a day, daily dose - 20-40 mg. Depending on the patient’s condition, it is used intravenously in the morning and intramuscularly in the evening; or within 10 days intravenously, then intramuscularly. The course of treatment is 15-30 days.

To relieve acute uncomplicated ethanol intoxication, as part of complex therapy, a saturating dose of 5 mg/kg and a maintenance dose of 1.56 mg/kg/h in a volume of 2.5 liters of infusion solution are administered for 4 hours, morning and evening.

For asthenic conditions, depending on the severity of the disease, in addition to oral administration, a daily dose of 20-40 mg is administered intramuscularly for 1 month.

Interaction

Reduces the duration of action of barbiturates.

Enhances the effect of narcotic analgesics.

Side effects

From the side of the central nervous system: irritability, agitation, anxiety, dizziness, headache.

Allergic reactions: skin rash, itching.

Other: nausea.

Indications

Cerebrovascular insufficiency, asthenia, depressive disorders in old age.

Conditions accompanied by anxiety, fear, increased irritability, emotional lability. Asthenic conditions caused by various neuropsychiatric diseases.

As part of complex treatment - to relieve acute alcohol intoxication; in chronic alcoholism - to reduce asthenic, asthenoneurotic, postpsychotic, pre-relapse conditions, as well as alcoholic encephalopathy.

Complex therapy includes migraine (prevention), head injury, neuroinfection.

Improving the tolerance of physical and mental stress (for persons under intense and extreme conditions of activity; to restore the physical performance of athletes, to increase resistance to physical and mental stress).

Open-angle glaucoma (to stabilize visual function).

In urological practice (in children over 3 years of age and in adults with urinary disorders) to improve the adaptive function of the bladder (reducing detrusor hypoxia).

Contraindications

Chronic renal failure, pregnancy, lactation, hypersensitivity to nicotinoyl gamma-aminobutyric acid.

Features of application

Use during pregnancy and breastfeeding

Use for renal impairment

Picamilon (nicotinoyl gamma-aminobutyric acid) belongs to, is widely used in medicine for the treatment of neurological, ophthalmological and urological pathologies, as well as chronic forms of alcoholism.

The drug restores brain function during, after, and other neurological diseases, as well as after effects of a physical, biological and chemical nature.

Composition and release form

The medicine is available in the form of tablets in dosages of 10, 20 and 50 mg, which are packaged in glass and polymer jars. The drug is also produced in a solution for intravenous and intramuscular injections. Ampoules contain 2 ml of solution.

The main active ingredient in the product is Nicotinoyl gamma-aminobutyric acid.

Pharmacological profile

Picamilon belongs to nootropic and vascular drugs. Its chemical composition is a combination of nicotinic acid and GABA molecules.

According to the pharmacological effects, Picamilon contains the properties of these two substances and has the following effect on the patient’s body:

• antiaggregation;
• antioxidant;
• nootropic;
• tranquilizing;
• restoring cerebral circulation;
• antimigraine;
• psychostimulant;
• normalizes the metabolism of brain tissue;
• reduces vascular resistance;
• increases microcirculation and brain flow rate.

Nicotinoyl gamma aminobutyric acid has the following formula

The drug is quickly and completely absorbed regardless of its entry into the body. Penetrates through the BBB and is retained in tissues for a long period.

It has a bioavailability of up to 90%, and half is excreted within an hour, mainly in the urine. Evenly distributed in the brain, muscles and adipose tissue.

According to research data, it is considered an effective metabolic treatment.

This drug organically and clearly combines nootropic, tranquilizing and vasoactive effects. This effect of Picamilon differs from other drugs of this pharmacological group.

Application profile and contraindications

Why is Picamilon prescribed and when is its use most justified:

Contraindications to the use of the medicine:

• It is not recommended to use the drug for liver and kidney pathologies;
• if the patient has hypersensitivity to the main substance and additional components that make up the medicine;
• cerebrovascular accident in the acute stage;
• bearing a fetus;
• lactation.

Regimen and dosage regimen

According to the instructions for use, you can take Picamilon tablets, as well as give injections, regardless of the time of day or meal, in the following dosages:

Overdose and possible side effects

In general, Picamilon is well tolerated by patients, but sometimes the following side effects may occur:

• nausea and vomiting;
• excitement;
• irritability;
• allergy.

If adverse symptoms occur, you should inform your doctor, who will adjust the treatment and, if necessary, reduce the dose.

There is no reliable data on cases of drug overdose. Sometimes the severity of side effects is noted when using high doses of the drug.

The daily dose of the drug should not exceed 300 mg. If there are symptoms of overdose, the patient is given detoxification therapy and, if necessary, somatic treatment is prescribed.

Special patients and conditions

When treating with the drug, you should avoid work associated with increased attention and danger. The product does not affect vehicle control. It is not recommended for children under 3 years of age; for children over three years of age, Picamilon is prescribed in urology to improve the adaptive function of the bladder.

It is prohibited to drink alcohol during treatment with Picamilon. Alcohol increases the effect of the drug on brain tissue and can lead to an overdose and the development of severe side effects. At the same time, the drug is used to treat withdrawal symptoms.

The drug is contraindicated in case of chronic kidney or liver pathology.

The drug increases the metabolism of barbiturates and reduces their effect on the body. Also, the main substance of the drug accelerates the effect when taking analgesics belonging to the group of narcotic drugs.

It is prohibited to prescribe the medicine while pregnant and during breastfeeding.

Practical application experience

The opinion of doctors and reviews of patients who have taken or are taking Picamilon for one purpose or another.

According to most patients, Picamilon is an effective remedy. The drug eliminates frequent migraine attacks quite well, improves memory and thinking, and eliminates negative symptoms.

With the help of the drug Picamilon, I was able to improve my memory and thinking. The medicine did not cause any side effects. It is comfortable to take and does not irritate the gastric mucosa. After completing the course I was satisfied with the result of the treatment.

Natalya, 40 years old

At work I constantly wanted to sleep, although I had sufficient and sound sleep at night. The doctor advised me to take this medicine.

After taking the pill for a week, my performance increased, my memory and general condition improved. I recommend this effective and affordable product to everyone.

Gleb, 43 years old

Only a specialist, after examining and examining the patient, can prescribe this or that drug. Self-treatment can lead to serious complications.

The doctor will be able to correctly select the dosage and choose the drug itself, taking into account all the individual characteristics of the patient. Picamilon is not just a vitamin preparation, but a rather serious drug that has its own contraindications and side effects.

At the moment, there is no consensus among doctors whether Picamilon is such an effective drug for neurological pathologies - some still believe that the placebo effect simply works.

Conclusion from practical experience

Advantages of the medicine:

• affordable price;
• low degree of side effects;
• is not addictive;
• Available in the form of tablets and injections.

Flaws:

• may not give a good result during treatment;
• long course of treatment;
• There is a burning sensation and pain at the injection site;
• does not penetrate into the brain in sufficient quantities and is distributed in large quantities to other organs and systems.

Purchase and storage of the drug

The drug is available in tablet form and solution for injection. In the Russian Federation the following prices for Picamilon:

• tablets 20 mg 30 pieces per package – 70 rubles;
• tablets 50 mg 30 pieces– 92 rubles;
• injection solution 10% 10 pieces– 135 rubles;
• injection solution 10% 5 pieces– 112 rubles.

The drug belongs to the list of group B. The medicine should be stored in a dark and dry place away from children. Storage temperature should not exceed +25 degrees, shelf life - 3 years.

The drug is dispensed at the pharmacy according to a prescription.

What can be replaced?

Now on the Russian pharmaceutical market there are many analogues and generics of the drug Picamilon:

Analogues include products with identical therapeutic properties and/or with the same active ingredient.

The drug Picamilon is an effective nootropic drug that improves cerebral circulation, improves memory, thinking, increases mental and physical endurance, and helps patients during the rehabilitation period after a stroke.

Also, the medicine, due to its antioxidant properties, improves blood microcirculation in the brain. Only a specialist can determine the dosage for the patient. You should not listen to the opinions of colleagues or neighbors and start taking medicine yourself. It should be remembered that this is a prescription medication and it has a number of contraindications and side effects.

The human brain, the main element of the central nervous system, is a complex device, without the normal functioning of which the body is not able to function normally. The most mysterious and functional organ of the human body should be given special attention and care.

In modern pharmaceuticals, there are many drugs created for the regeneration of brain cells and their restoration. These are nootropic drugs, one of which is Picamilon. But, before using this remedy, you should understand why Picamilon is prescribed and become familiar with its side effects.

Picamilon is a Russian-made nootropic drug

This nootropic is a monocomponent, that is, consisting of one active component: nicotinoyl gamma-aminobutyric acid. During manufacture, a number of necessary auxiliary elements are added to the medicine:

• talc;
• starch;
• calcium stearate.

Nicotinoyl gamma-aminobutyric acid (NICOTINOYL GAMMA-AMINOBUTYRIC ACID) is a crystalline white powder. This component is hygroscopic and highly soluble in water.

NGAC belongs to a number of nootropics that improve metabolism (metabolism) of the brain and belongs to a number of multivitamins.

The dosage of the tablet is 20 or 50 mg. In the form of an injection solution, the substance is dosed at the rate of 100 mg per milliliter.

What is the medicine for?

To understand what Picamilon tablets do and how they help patients, you need to consider the effects that the medicine has. Its main effect is the expansion/restoration of blood vessels and activation of stimulatory parts of the brain. This drug actively affects higher mental brain functions.

Picamilon has been successfully used to treat alcohol withdrawal

According to the results of studies conducted by WHO (World Health Organization), nootropic drugs act on humans as follows:

1. Regulate memory processes.
2. Restores the ability to perceive new information.
3. Increases the resistance of the central nervous system to the negative influence of external factors.

Features of the drug

Picamilon (unlike a number of other medications) does not cause persistent dependence of the body and does not provoke the development of weakness. A person’s physical capabilities remain at the same level, they are not depleted. The effect of the drug occurs due to the improvement of metabolic processes and a direct effect on the blood vessels of the brain.

Indications for use of the drug

To understand what the medicine Picamilon is for, it is necessary to study the effects that this medicine has on humans. Here is their complete list:

1. Psychostimulation. Helps to mentally prepare a person for any necessary action. A kind of “toning” of the nervous system occurs.
2. Antiasthenic effect. Relieves severe weakness, lethargy, eliminates fatigue and increased exhaustion. Such symptoms are characteristic of people with various pathologies.
3. Antidepressant effect. Relief of anxiety, inexplicable fear, and various depressive symptoms.
4. Adaptogenic influence. Increasing the body's strength to respond to numerous negative external stimuli (environmental pollution, working in hazardous industries, passive smoking).
5. Vasovegetative effects. Restoring the regulation of vegetative processes: improving metabolism, increasing tissue excitability. The product normalizes the activity of internal resources and behavioral reactions.
6. Mild sedative effect. The drug has a mild sedative effect in neurosis-like conditions.

Picamilon also works to increase the clarity of a person’s thinking, improves learning processes, concentrating the ability to memorize new information. Reanimates speech functions and parts of the brain responsible for memory.

When is Picamilon prescribed?

What Picamilon helps with is the main and pressing question that faces a person when a doctor recommends this drug to him. Nootropic drugs work by stimulating and activating the metabolic processes of brain cellular tissue. Thanks to this, the drug significantly helps in the fight against the following problems (diagnosed pathologies or conditions):

• asthenic syndrome;
• vegetative-vascular dystonia;
• open-angle glaucoma;
• depressive states typical of older people;
• moderate/mild cerebral circulation problems;
• in order to restore physical condition after difficult sports competitions;
• in the complex treatment of chronic alcoholism and alcohol intoxication of any type;
• as an adjuvant in the treatment of migraine (Picamilon is used for preventive purposes);
• to relieve excessive physical stress of persons involved in hard work, experiencing psychological tension due to the specifics of the work;
• cerebrovascular insufficiency (when small areas of degradation appear in the brain, the development of which occurs due to circulatory disorders).

Picamilon and alcohol intoxication

This original Russian-made drug is successfully used in the treatment of alcohol intoxication of varying degrees of severity. For hangover syndrome, Picamilon effectively relieves headaches, eliminates anxiety, quickly restoring sleep and performance.

Pharmacological action of the drug

At the same time, the product blocks the destructive effect of ethyl alcohol on the human body, in particular on the central nervous system. But it does not cause addiction or drowsiness.

The drug is also actively used by doctors when withdrawing patients from deep, long-term drinking. But you should know that this medicine only works to reduce the negative effects of ethyl alcohol on the functionality of the body. But he is unable to solve the problem of swelling and impaired fluid redistribution associated with intoxication.

How to take the product correctly

Picamilon is produced in several forms. The correct use of the drug and the recommended dose depend on this. Before using the medication, you must carefully study the attached instructions.

Before using the product, you must carefully study the instructions

How to take Picamilon tablets

The tableted drug should be taken orally, whole tablets (crushing and dissolving them in liquid is not recommended). Take the tablets with plenty of purified water (100-150 ml).

Picamilon tablets are allowed to be taken regardless of meals, at any time convenient for the person.

The dosage of Picamilon and the duration of the course of use depend on each specific case and the diagnosed problem:

How to take Picamilon tablets, the instructions for which say that the drug helps relieve a person from a hangover? To relieve intoxication caused by excessive alcohol consumption, the drug is used at a daily dose of 150-200 mg for the entire hangover day. The number of pills depends on the form of release of the medicine: 10, 20, 30 or 50 mg.

Application of the product in injections

Picamilon in injection form is used only in difficult cases, with serious and severe neurosis-like conditions or severe cerebrovascular accident. The concentrated product is administered intramuscularly or intravenously (jet or infusion injections).

What do Picamilon ampoules look like?

The product is also used by drip administration. For droppers, an ampoule of the medication is diluted with saline solution (200 ml). The drug is dosed based on the patient’s age:

• children 100 mg/day;
• adults – 200 mg/day.

In some cases, the daily dose of medication can be divided into a couple of doses. The duration of the course of treatment in injection form is about 1.5-2 weeks.

Beware, danger!

This medication has a minimum of side effects and is almost always well tolerated by all patients. It can be prescribed even to children. But, like any drug, Picamilon has some conditions under which its use is limited.

Side effects

• nausea;
• the appearance of headache;
• slight dizziness;
• redness of the skin;
• allergic rash such as urticaria;
• increased anxiety, irritability;
• when used intravenously, a feeling of “goosebumps” was noted.

Side effects with Picamilon are very rare.

As a rule, such negative consequences are expressed so weakly that they do not affect the quality of life in any way.. But, if side effects cause inconvenience, doctors lower the dosage of the drug or replace it.

Contraindications

Picamilon also has a number of contraindications to its use. There are a number of patients who should forget about taking the medicine due to the following contraindications:

1. Chronic renal pathologies.
2. The period of pregnancy and breastfeeding.
3. Excessive sensitivity to the components of the product.

The drug should be used with extreme caution if a severe stage of cerebral circulatory disorders is detected. You should also know and remember that Picamilon enhances the medicinal effect of analgesics (if they contain narcotic components). But the effect of barbiturates, on the contrary, reduces.