Likopid Zodak and Codelac are compatible medications. Likopid (the latest generation immunomodulator): reviews from immunologists

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Lycopid represents immunomodulator new generation, designed for complex therapy various secondary immunodeficiencies in adults and children. Since secondary immunodeficiency can occur against the background of various chronic or frequent infectious inflammatory diseases, then the immunomodulator is used in the treatment of all these conditions, such as, for example, infections respiratory tract, pustular diseases skin and soft tissues, furunculosis, tuberculosis, viral infections(herpes, hepatitis, etc.), psoriasis.

Composition, varieties and release forms

As auxiliary components, tablets of both dosages contain the following substances:

• Calcium stearate;
• Potato starch;
• Lactose monohydrate;
• Methylcellulose;
• Sucrose.

Despite the fact that Lykopid varieties differ from each other only in the amount of active substance, this different drugs, each of which has its own characteristics and rules of application. You also need to know that Likopid 1 mg is available without a doctor's prescription, and Likopid 10 mg is available only with a prescription. Likopid 1 mg is suitable for both prevention and treatment, and can also be used for both adults and children over 3 years of age, and Likopid 10 mg is intended exclusively for the treatment of adults.

Action of Lykopid

In principle, the action of Lykopid is somewhat similar to a vaccination, when killed or weakened bacteria are introduced into the body, to which antibodies are produced and immunity to infection is acquired. Only the effect of Lykopid, in contrast to vaccination, is broader, since the drug leads to the acquisition of immunity not to one disease, but immediately to a wide range of infections caused by the most common pathogenic microorganisms.

The effect of the drug is realized due to its connection with the NOD2 protein, which is present in the cells of the immune system, against the background of which their activation occurs. Likopid increases the activity of phagocytes, natural killer cells (NK cells), T- and B-lymphocytes, increases the amount of antibodies produced and normalizes the ratio of T-helper types 1 and 2.

The toxicity of Lykopid is very low, since the dose at which half of the experimental mice die is 106,000 times higher than the therapeutic dose. When people take the drug in dosages 100 times higher than recommended, there is no toxic effect on the nervous and cardiovascular systems, as well as on other internal organs. Also, Lykopid does not cause mutations and does not have toxic effect for the fruit.

IN experimental studies It was shown in laboratory animals that Lykopid has an antitumor effect.

Indications for use

1. Children (3 – 18 years old) and adults (over 18 years old):

• Treatment of chronic respiratory tract infections, including those associated with acute respiratory infections, flu and colds (for example, bronchitis, sinusitis, pharyngitis, laryngitis, etc.) during exacerbation or remission;
• Treatment of acute and chronic purulent-inflammatory diseases of the skin and soft tissues (for example, furunculosis, pyoderma, etc.);
• Treatment herpetic infection(genital herpes, labial herpes, cytomegalovirus infection, Epstein-Barr virus).

• Prevention of acute respiratory infections and influenza during seasonal epidemics, as well as reducing the frequency of exacerbations chronic diseases ENT organs and respiratory tract.

• Acute or chronic purulent-inflammatory diseases of the skin and soft tissues (for example, furunculosis, abscess, phlegmon, postoperative complications etc.);
• Sexually transmitted infections (human papillomavirus infections, trichomoniasis, difficult to treat);
• Herpetic infections various localizations(genital herpes, ophthalmoherpes, herpes keratitis, Epstein-Barr virus, cytomegalovirus infection etc.);
• Psoriasis (including psoriatic arthritis);
• Pulmonary tuberculosis.

Instructions for use

General admission rules

The Lykopid 1 mg tablet is optimally taken sublingually, that is, placed under the tongue and held until completely dissolved. You should not try to dissolve or intensively move the tablet under the tongue in order to dissolve as quickly as possible. You need to wait for the tablet to dissolve naturally. If for some reason it is impossible to take Likopid 1 mg sublingually, then the tablet can simply be swallowed whole with a small amount of water.

Likopid 1 mg and 10 mg are recommended to be taken daily at the same hours. If you accidentally missed another dose of the drug, but less than 12 hours have passed since the moment when you needed to take the pill, you can take the missed dosage. If more than 12 hours have passed since the scheduled dose, then only one subsequent dosage of Lykopid should be taken. You should not take the missed dose, nor do you need to double the next dose.

It must be remembered that children aged 3 – 18 years can only be given Lycopid 1 mg. Adults over 18 years of age can be given both Lycopid 1 mg and Lycopid 10 mg. But for adults, Likopid 10 mg should be used only when severe course infections. In addition, it is recommended to always start treatment with Lycopid 1 mg, and only if it is ineffective, switch to Lycopid 10 mg.

Dosage Likopid 1 mg

• Treatment of acute and chronic inflammatory diseases of the skin and soft tissues - take 1 tablet (1 mg) once a day for 10 days;
• Treatment of chronic respiratory tract infections - take 1 tablet (1 mg) once a day for 10 days. Conduct three ten-day courses of application with intervals between them lasting 20 days;
• Treatment of herpetic infections of various localizations - take 1 tablet (1 mg) 3 times a day for 10 days.

• Treatment of chronic respiratory tract infections - take 2 tablets at a time (2 mg) once a day for 10 days;
• Treatment of acute purulent-inflammatory diseases of the skin and soft tissues - take 2 tablets at a time (2 mg) 2 - 3 times a day for 10 days;
• Treatment of herpetic infection - take 2 tablets at a time (2 mg) three times a day for 10 days;
• Prevention of acute respiratory infections and influenza during seasonal epidemics, as well as reducing the frequency of relapses of diseases of the ENT organs and respiratory tract - take 1 tablet (1 mg) 3 times a day for 10 days.

Photo of the packaging of Likopid 1 mg:

Dosage Likopid 10 mg

• Treatment of acute and chronic purulent-inflammatory diseases of the skin and soft tissues - take 1 tablet (10 mg) once a day for 10 days;
• Treatment of herpes infection of any location, except ophthalmic herpes - take 10 mg (1 tablet) once a day for 6 days. For ophthalmoherpes, you should take the drug according to the following regimen - 10 mg (1 tablet) 2 times a day for 3 days. Then take a three-day break, after which the course of therapy is repeated;
• Treatment of sexually transmitted infections - take 10 mg (1 tablet) once a day for 10 days;
• Treatment of psoriasis – take 10–20 mg at a time (1–2 tablets) once a day for 10 days. If the course of psoriasis is severe, then the drug is taken 1 tablet (10 mg) 2 times a day for 20 days. After this, for any severity of psoriasis, continue to take 10–20 mg (1–2 tablets) once a day every other day without interruption. In the every other day regimen, only 5 tablets are taken;
• Treatment of pulmonary tuberculosis as part of complex therapy - take 10 mg (1 tablet) once a day for 10 days.

Photo of the packaging of Likopid 10 mg:

Use during pregnancy and breastfeeding

special instructions

In addition, Lykopid 1 mg and 10 mg contain lactose, so the drug is not recommended for use by people suffering from intolerance to this carbohydrate.

Likopid 10 mg should be used with caution in elderly people (over 65 years of age) and only under the close supervision of a physician.

At the beginning of taking Likopid 10 mg, exacerbation of chronic diseases is possible, which is normal reaction body to the drug. In such cases, treatment must be continued.

People suffering from both psoriasis and gout should take Licopid 10 mg only as prescribed by a doctor after assessing the risk/benefit ratio, as they are at risk of developing gouty arthritis or joint swelling. In addition, patients suffering from both psoriasis and gout should start taking the drug at half the dosage, and only increase it to the recommended dosage if there are no side effects.

Impact on the ability to operate machinery

Overdose

Interaction with other drugs

Antacid drugs (for example, Maalox, Phosphalugel, Almagel, etc.) and sorbents (Polysorb, Polyphepan, Lactofiltrum, Filtrum, Enterosgel, etc.) reduce the absorption of Lykopid 1 mg and 10 mg. Therefore, it is necessary to space the intake of sorbents or antacids and Lykopid by 1 to 2 hours. That is, Likopid should be taken 1 - 2 hours before or after antacids or sorbents.

Glucocorticosteroid hormones (for example, Dexamethasone, Prednisolone, etc.) reduce the severity therapeutic action Lykopida 1 mg and 10 mg.

Lykopid for children

General provisions

As a rule, Likopid 1 mg in children is used to treat various infections upper respiratory tract, frequent colds, acute respiratory infections or flu. For all other conditions for which the use of Likopid 1 mg is indicated for children, the drug is used much less frequently.

Instructions for use of Lykopid for children

Dosages and duration of therapy with Likopid 1 mg for various diseases in children are shown in the table.

Lykopid for psoriasis

So, when mild psoriasis or medium degree severity, the drug is used according to the following scheme: take 1 - 2 tablets (10 - 20 mg) at a time, once a day for 10 days. Then take 1 - 2 tablets (10 - 20 mg) five more times, 1 time per day every other day.

For severe psoriasis, Licopid 10 mg is used according to the following regimen: take 1 tablet (10 mg) once a day for 20 days. Then take 1 - 2 tablets (10 - 20 mg) five more times, 1 time per day every other day.

The indicated schemes are the same for both the period of exacerbation and remission. During the period of remission, you can only take Likopid 10 mg, and during an exacerbation, the drug should be used only in combination with other necessary medications as part of complex therapy.

Side effects

• A short-term increase in temperature no higher than 37.9 o C (there is no need to stop the drug and take antipyretics). This side effect is observed frequently and occurs in 1–10% of people taking Likopid 1 mg;
• An increase in body temperature above 38.0 o C (there is no need to discontinue the drug, but antipyretics should be taken until body temperature normalizes). This side effect is rare and develops only in 0.01 - 0.1% of people taking Likopid 1 mg;
• Diarrhea (no need to discontinue the drug). It develops very rarely - in less than 0.01% of people taking the drug.

Lykopid 10 mg may cause the following side effects:

• Joint pain (develops in 1–10%);
• Muscle pain (develops in 1–10%);
• A short-term increase in body temperature of no more than 37.9 o C (develops in 1 - 10%);
• An increase in body temperature of more than 38 o C (develops in 0.01 - 0.1%). IN in this case It is recommended to additionally take antipyretic drugs (for example, Paracetamol, Ibuprofen, Nimesulide, Aspirin, etc.);
• Diarrhea (develops in less than 0.01%).

Any of the listed side effects are not an indication for discontinuation of the drug, therefore, if they occur, you should continue taking Likopid 10 mg until the end of the course of therapy. However, if the severity of side effects increases or any other symptoms appear, you should stop taking the drug and consult a doctor.

Contraindications for use

• Individual increased sensitivity to any components of the drug;
• Pregnancy and breastfeeding period;
• The period of exacerbation of Hashimoto's autoimmune thyroiditis;
• Metabolic disorders in which sucrose is not utilized (alactasia, galactosemia, lactase deficiency, lactose or fructose intolerance, sucrase/isomaltase deficiency, glucose-galactose malabsorption);
• Age under 18 years (only for Lykopid 10 mg);
• Body temperature above 38 o C at the time of administration (only for Lykopid 10 mg).

Likopid - analogues

So, the following drugs are analogues of Lykopid in terms of therapeutic effect:

• Actinolysate solution for injection;
• Alfaron lyophilisate for the preparation of a solution for intranasal administration;
• Anaferon and Anaferon children's tablets;
• Arpetolide tablets;
• Affinoleukine lyophilisate for the preparation of solution for injection;
• Bioaron S syrup;
• Broncho-Vaxom adult and children's capsules;
• Broncho-Munal and Broncho-munal P capsules;
• Viferon rectal suppositories, gel and ointment;
• Wobe-mugos E tablets;
• Genferon Light spray for nasal use and vaginal and rectal suppositories;
• Herbion Echinacea tablets;
• Giaferon vaginal and rectal suppositories;
• Dr. Theiss echinacea extract lozenges, infusion and oral solution;
• Isofon capsules;
• Immunal drops for oral administration and tablets;
• Immunal plus C oral solution;
• Immunex syrup;
• Immunorm tablets;
• Imunorix solution for oral administration;
• Interlock lyophilisate for the preparation of eye drops;
• Ismigen sublingual tablets;
• Lokferon lyophilisate for preparing a solution for local application;
• Myelopid powder for the preparation of solution for injection;
• Polymuramyl solution for injection;
• Polyoxidonium tablets, lyophilisate for the preparation of solution for injection and topical use, vaginal and rectal suppositories;
• Ribomunil tablets and granules for the preparation of solution for oral administration;
• Ridostin lyophilisate for the preparation of solution for injection;
• Stemokin solution for injection;
• Stimforte lyophilisate for the preparation of solution for injection;
• Taktivin injection solution;
• Timaktide sublingual tablets;
• Thymogen nasal drops, cream, solution, lyophilisate for the preparation of solution for injection, nasal spray;
• Florexil drops for oral administration;
• Tsitovir-3 capsules, syrup, powder for the preparation of solution for oral administration;
• Estifan tablets;
• Echinacea purpurea extract liquid for oral administration;
• Echinacea homeopathic granules, drops for oral administration, lozenges, tablets, tincture;
• Echinacea compositum CH solution for injection;
• Echinokor elixir.

Seasonal weather changes, medications, or a weakened immune system increase the risk of exacerbation of chronic diseases or contracting viral infections. To treat and prevent such conditions, doctors often prescribe immunomodulatory drugs.

The modern pharmacological market presents the latest remedy, having wide range actions – Lykopid.

Currently a small amount of drugs of this pharmacological group is different natural composition. Lykopid went through many clinical trials, which confirmed its effectiveness and safety. Likopid is characterized by the absence of toxic effects on the human body. It does not have teratogenic or embryotoxic effects and does not cause chromosomal mutations. In this regard, it is actively used in pediatrics to strengthen the child’s immunity.

Compound

The composition of the medicine, according to the instructions, includes the active ingredient glucosaminylmuramyl dipeptide, and Excipients: lactose, sucrose, potato starch, calcium stearate, methylcellulose.

Likopid is produced in the form of tablets in dosages of 1 mg and 10 mg.

Photo of the drug Lykopid

The white tablets are cylindrical in shape and contain varying amounts of the active ingredient. The drug is packaged in contour cells.

The manufacturer of Likopid is the Russian pharmaceutical company Peptek.

pharmachologic effect

Lycopid represents a modern immunomodulatory agent.

The action of the drug is aimed at destroying pathogenic viruses, bacteria and fungi in the human body, preventing the development of the inflammatory process. The drug triggers the production of a cytokine - a protein-peptide compound that helps increase the formation of leukocytes and new antibodies. Likopid strengthens the cells of the human immune system.

Once in the blood, the drug starts the process of immunoregulation, which becomes active when it enters the body pathogenic microorganisms. The human body begins to produce cytokines, interferons, and colony-stimulating factors.

Lykopid stimulates the work of congenital immune cells– phagocytes, which are most active against foreign microorganisms. In addition, the drug is able to suppress the activity of tumor and metastatic cells.

According to the instructions for use, the drug is used for complex therapy of a number of diseases in which secondary manifestations are possible. immunodeficiency states:

Contraindications

Before using the drug, you must carefully read the instructions, since the drug has a number of contraindications. The use of Lykopid is prohibited in the presence of the following diseases and pathological conditions:

• intolerance to the components of the drug;
• autoimmune diseases;
• metabolic disease;
• increase in body temperature above 38 degrees at the time of use of the drug;
• pregnancy and lactation period.

Instructions for use

The drug is used sublingually or orally half an hour before meals on an empty stomach.

For the treatment of adult patients in postoperative period use 1 mg 1 time per day for 10 days.

For purulent-septic diseases of soft tissues, use 2 mg of the drug three times a day. For severe forms of the disease, 10 mg of the drug can be used once a day.

When infectious diseases respiratory tract Lykopid is used sublingually 1 mg per day. The duration of treatment is 10 days.

For adult patients with a mild form of herpes infection, use 2 mg of the drug sublingually twice a day. The duration of use of the drug is 6 days. Treatment of ophthalmoherpes requires the use of Lykopid 10 mg 2 times a day for 3 days. Then, after a three-day break, the drug should be continued.

For psoriasis in adults, 10–20 mg 2 times a day can be used. The course of treatment is 10 days. If the affected area is large, you can use 1 mg of Lykopid 2 times a day. The duration of use of the drug is 20 days.

Use of the drug in childhood

According to doctors, the use of Likopid for children is most effective during the child’s adaptation to preschool institution or school. Sometimes a child’s immunity, without additional support, cannot withstand the effects of viruses and harmful microorganisms. The use of an immunomodulator will help to resist numerous diseases that a child encounters when socializing in a group of children.

For children from one to 16 years of age, the drug is prescribed in the form of tablets with a dosage of 1 mg. Before use, Likopid tablets for a child should be thoroughly crushed and dissolved in warm boiled water.

For the treatment of bronchitis, laryngitis, pharyngitis, a tablet is prescribed once a day. The duration of use of the drug should be agreed with the attending physician. As a rule, it lasts no more than 10 days.

It is prohibited to use the drug for a child without a pediatrician’s prescription, even to strengthen the immune system.

For the treatment of a newborn child with a prolonged viral infection, Lykopid is prescribed 500 mcg twice a day for 7 days. Treatment of hepatitis B and C is carried out using 1 mg of the drug three times a day. The treatment period is 20 days.

Side effects medicinal product, according to doctors, minimal amount. In some cases, patients may experience slight increase in temperature. In this case, it is necessary to take an antipyretic drug; doctors do not advise stopping the use of Lykopid.

It is also worth paying attention to the sucrose and lactose contained in the medicine, which can cause allergies.

Some patients may experience muscular and joint pain , V in rare cases – diarrhea.

special instructions

• When simultaneous use Lycopid and antibiotics penicillin group, cephalosporin, the effect of antibiotics is enhanced.
• Likopid becomes less bioavailable when used with antacids and adsorbents.
• It is not recommended to use Lykopid together with sulfonamides and tetracyclines.
• The use of the drug is incompatible with the consumption of alcoholic beverages.

Lykopid analogues

Price

Likopid is sold in pharmacies or online stores with a doctor's prescription. The price of the drug depends on the dosage of the drug and the number of blisters in the package.

The price of Lykopid 10 mg is from 1,500 rubles per pack, the price of a blister with ten 1 mg tablets is 300 rubles.

A common cause of viral and infectious diseases is low immunity. The complex therapy regimen for these pathologies includes immunomodulators that stabilize protective system body. Likopid - instructions for use indicate that these tablets and their analogues help normalize adult and children's immunity, the drug has many positive feedback from doctors. The medicine belongs to the group of new generation drugs and has a wide range of applications.

What is Lykopid

This tool belongs to a new generation of immunomodulators that are used for complex therapy in a child or adult with various secondary immunodeficiencies. They arise against the background of frequent, chronic infectious and inflammatory diseases:

• for tuberculosis;
• furunculosis;
• viral infections;
• psoriasis;
• herpes;
• respiratory tract infections.

Compound

Likopid produces only in the form of tablets that are taken orally; the packaging must contain instructions. Active active substance– glucosaminylmuramyl dipeptide (gmdp), which can be in the amount of 1 mg or 10 mg. These are two options for the release form of the medication, which according to the instructions have different conditions and dosage of use. The tablets also contain the following excipients:

• lactose monohydrate;
• calcium stearate;
• sucrose;
• potato starch;
• methylcellulose.

Likopid is available in the form of round, flat-cylindrical white tablets with a bevel. Medicines of 10 mg also have a risk so that they can be distinguished from 1 mg. The difference in the amount of active substance makes these forms different from each other; they are prescribed for different pathologies and with different rules reception. You can buy Likopid 1 mg in a pharmacy without a doctor's prescription, but 10 mg - only with a prescription.

Indications for use

The immunomodulator Likopid, according to the instructions, can be given to a child of any age, taking into account some features. For adults, the use of this medication is recommended in following cases:

• for papillomavirus infection;
• with ophthalmoherpes;
• for purulent-inflammatory skin diseases;
• at chronic infections lungs;
• for postoperative complications;
• with herpetic infection;
• for hepatitis B, C;
• at pulmonary tuberculosis;
• psoriasis.

Contraindications

According to the instructions, each medication has a number of prohibitions on use, which the patient must comply with. For example, Likopid and alcohol are incompatible during treatment; other contraindications include the following conditions:

• According to the instructions, it is not recommended to take Likopid if hyperthermia is above 38 degrees or there is a febrile state;
• It is necessary to refuse in case of exacerbation of thyroiditis of autoimmune origin4
• According to the instructions, use is prohibited in the presence of hypersensitivity to the components of Lykopid;
• The medication is contraindicated during pregnancy and nursing mothers.

Side effects

If you violate the rules for using the medication according to the instructions, you may experience Negative consequences. Likopid tablets can cause short-term low-grade fever, and sometimes muscle and joint pain occurs. Side effects occur, as a rule, when exceeding permissible dosage(over 20 mg). Hyperthermia rarely occurs; to reduce the temperature, it is recommended to take an antipyretic drug, which will not affect the effect of Licopid. Less than 0.01% of patients experience diarrhea.

Lykopida instructions

There are features of taking and dosing the medication that the doctor takes into account when prescribing pediatric treatment or a course for adults. There are also general rules, which are described in the annotation for the drug. The tablet must be swallowed whole; it must not be crushed or ground into powder. Next you need to drink a large amount of water. Take Likopid half an hour before meals on an empty stomach.

According to the instructions, you need to take Likopid 1 mg sublingually - put the tablet under your tongue and wait until it is completely dissolved. You should not try to move its intensity with your tongue or dissolve it in order to speed up dissolution. If for some reason this method of administration cannot be carried out, then you should swallow the tablet whole with a glass of water. large quantities.

According to the instructions, the use of Lykopid is recommended at the same time. If you miss the next dose, you can take a pill if less than 12 hours have passed since the previous use. If more time has passed, then you only need to take next dose without increasing it. Children can only take Likopid 1 mg; adults can take 10 mg, but only if the disease is complex or a lower dosage is ineffective.

For children

Use for a child allows a dosage of only 1 mg. Likopid for children is prescribed according to following rules according to instructions:

1. Once a day for 10 days you need to take 1 tablet for the treatment of chronic, acute inflammatory pathologies soft tissues and skin.
2. The same regimen, according to the instructions, is used in the treatment of chronic respiratory tract infections. The course must be repeated 3 times with an interval of 20 days.
3. 3 times per knock for 10 days, 1 tablet is needed for herpes infection of any location.

For adults

Medication intake varies depending on treatment various pathologies. Likopid for adults is recommended to be taken according to the following rules:

1. Treatment of the respiratory tract for chronic infection - 1 tablet 2 times a day for 10 days.
2. Treatment of soft tissues, skin with purulent-inflammatory diseases in acute form carried out using 2 tablets 2-3 times a day for 10 days.
3. For the treatment of herpes infection, it is recommended to take 2 tablets three times a day for 10 days.

To prevent acute respiratory viral infections, acute respiratory infections during seasonal flu epidemics, and to reduce the likelihood of relapses of pathologies of the ENT organs, it is recommended to drink 1 tablet 3 times a day for 10 days. For older people (over 65 years of age) and those who have impaired liver or kidney function, the dosage is not reduced; they must take the medicine in the established norms according to the instructions.

Lykopid for psoriasis

For the treatment of this pathology, adults are prescribed 10 mg tablets, the recommended number of doses is 3 per day, the course duration is 10 days. After a one-day break, you can repeat the treatment regimen again, but only 1 tablet per day. If the symptoms are pronounced, the course of the disease is severe, or psoriatic arthritis has developed, then you need to take the medication twice a day for 20 days. Children's dosage (up to 16 years) – 1 mg 3 times a day for 10 days.

Lykopid (glucosaminylmuramyl dipeptide) is an immunotropic drug of the muramyl dipeptide series. This group medicines was introduced into medical practice in the 70s of the last century, but until now only two such drugs are used: the Japanese Romurtide and the Russian Likopid. Last - original development domestic scientists, who turned out to be by-product research antitumor drug blastolysin. Lykopid is a pronounced immunostimulant with a weak pyrogenic effect, which has a multidirectional effect on the immune system. The drug is endowed with the ability to stimulate both the cellular and humoral components of the immune response. Clinical study of the drug in leading Russian clinics was carried out in three stages in accordance with the standards of Appropriate clinical practice. The drug passed all testing procedures with honor and was indicated for use in medical practice V combination treatment secondary immunodeficiency conditions, including chronic nonspecific diseases of the respiratory tract, postoperative or post-traumatic inflammatory processes with heavy exudation, genitourinary tract infections, herpetic infections, cytomegalovirus, candidiasis, etc. For chronic nonspecific diseases respiratory tract, the drug significantly increases the period of remission after a course drug therapy. When treating complications that develop after surgical interventions, Likopid prevented their further progression, and if used as a prophylactic agent, did not allow them to develop. Likopid increases the level of neutrophils, reduces the concentration of creatinine, urea, and bilirubin. In patients with trophic ulcers the drug stops inflammatory processes, promotes cleansing and closing of the wound by the beginning of the third week of pharmacotherapy.

It is important that in some cases the drug provided the necessary therapeutic effect without the use of antibiotics. This fact proves that Lykopid is capable of stimulating repair processes. Good results the drug also shows in treatment herpetic lesions cervix, and as in complex treatment, and as part of monotherapy: a decrease in the number of relapses, the disappearance of koilocytosis, and an increase in the number of completely recovered patients were noted. The effectiveness of Lykopid increases when used together with antibiotics and antiviral drugs. With the combined treatment of herpesvirus infections, a significant improvement in the clinical situation is observed already on the 3-4th day of pharmacotherapy. The peak concentration of the active component of the drug is observed 1.5 hours after administration. The drug has a relatively low bioavailability - about 10% at orally. The half-life of Lykopid is 4.3 hours. Elimination from the body is carried out by the kidneys. Optimal time reception - half an hour before meals. Method of administration: sublingual (sublingual) or orally by swallowing. On initial stage pharmacotherapy, it is possible to increase the temperature to a subfebrile level, which goes away on its own and does not require stopping the medication course. Use of Licopid during pregnancy and during breastfeeding not allowed. The drug can be used in pediatric practice after the child reaches one year old. Tetracyclines and sulfonamides are not suitable for combination with Lykopid.

Pharmacology

Immunostimulating drug biological activity which is due to the presence of specific binding centers (receptors) for GMDP, localized in the endoplasm of phagocytes and T-lymphocytes.

The drug stimulates the functional (bactericidal, cytotoxic) activity of phagocytes (neutrophils, macrophages), enhances the proliferation of T- and B-lymphocytes, and increases the synthesis of specific antibodies.

The pharmacological action is carried out by enhancing the production of interleukins (interleukin-1, interleukin-6, interleukin-12), tumor necrosis factor-alpha, interferon gamma, colony-stimulating factors.

The drug increases the activity of natural killer cells.

Pharmacokinetics

Suction and distribution

Cmax of the active substance in plasma is achieved 1.5 hours after administration. Oral bioavailability is 7-13%.

The degree of binding to blood albumin is weak.

Metabolism and excretion

Does not form active metabolites.

T1/2 is 4.29 hours. It is excreted unchanged, mainly in the urine.

Release form

Tablets are white, round, flat-cylindrical, with a bevel.

Excipients: lactose, sucrose, potato starch, methylcellulose, calcium stearate.

10 pieces. - contour cellular packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (2) - cardboard packs.

Dosage

Likopid ® is prescribed sublingually or orally on an empty stomach, 30 minutes before meals.

For the prevention of postoperative complications, Likopid ® is prescribed sublingually for adults at a dose of 1 mg 1 time per day for 10 days.

For the treatment of purulent-septic processes of the skin and soft tissues moderate severity(including postoperative) Likopid ® is prescribed sublingually at 2 mg 2-3 times a day for 10 days.

For the treatment of severe forms of purulent-septic processes of the skin and soft tissues, Likopid ® is prescribed orally at a dose of 10 mg 1 time per day for 10 days.

For chronic infections of the upper and lower sections respiratory tract Likopid ® is prescribed sublingually 1-2 mg 1 time/day for 10 days.

For pulmonary tuberculosis, Likopid ® is prescribed orally at a dose of 10 mg 1 time/day for 10 days.

At mild form for herpetic infection Likopid ® is prescribed sublingually 2 mg 1-2 times a day for 6 days; in severe forms - sublingually 10 mg 1-2 times a day for 6 days. For ophthalmic herpes, Licopid ® is administered orally at a dose of 10 mg 2 times a day for 3 days. After a break of 3 days, the course of treatment is repeated.

If the cervix is ​​affected by the human papillomavirus, Likopid ® is prescribed orally at a dose of 10 mg 1 time per day for 10 days.

For the treatment of psoriasis, Licopid ® is prescribed orally at a dose of 10-20 mg 1-2 times a day for 10 days and then 10-20 mg every other day for the next 10 days, with severe forms and a large area of ​​damage (including in the arthropathic form) - 10 mg orally 2 times a day for 20 days.

For the treatment of chronic respiratory tract infections and purulent-inflammatory skin diseases, Likopid ® is prescribed orally at a dose of 1 mg 1 time per day for 10 days.

When treating herpes infection, the drug is prescribed orally at a dose of 1 mg 3 times a day for 10 days.

In the treatment of chronic viral hepatitis B and C - orally at a dose of 1 mg 3 times a day for 20 days.

Newborns at protracted current infectious diseases (including pneumonia, bronchitis, enterocolitis, sepsis, postoperative complications) Likopid ® is prescribed orally at a dose of 500 mcg 2 times a day for 7-10 days.

Overdose

Interaction

At simultaneous use Likopid ® increases the effect of antibiotics from the group of semisynthetic penicillins, cephalosporins, polyene derivatives, fluoroquinolones, synergism is noted with respect to antiviral and antifungal drugs.

Antacids and adsorbents, when used simultaneously with Lykopid, significantly reduce its bioavailability.

GCS, when used simultaneously, reduces the effectiveness of Lykopid.

Side effects

Possible: at the beginning of treatment - an increase in body temperature to 37.9°C (it is short-term, goes away on its own and does not require discontinuation of the drug).

Indications

As part of complex therapy for conditions accompanied by secondary immunodeficiencies, including:

Tablets 1 mg and 10 mg (adults)

• for chronic lung infections;
• for acute and chronic purulent-inflammatory diseases of the skin and soft tissues (including purulent-septic postoperative complications);
• for herpes infection (including ophthalmic herpes);
• for papillomavirus infection;
• for chronic viral hepatitis B and C;
• for psoriasis (including arthropathic form);
• with pulmonary tuberculosis.

Tablets 1 mg (for children)

• for acute and chronic purulent-inflammatory diseases of the skin and soft tissues;
• for chronic infections of the upper and lower respiratory tract, both in the acute stage and in the remission stage;
• for herpetic infection of any localization;
• for chronic viral hepatitis B and C.

Contraindications

• autoimmune thyroiditis in the acute phase;
• diseases accompanied high fever or hyperthermia (>38°C);
• pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to the drug.

Features of application

Use during pregnancy and breastfeeding

The use of the drug during pregnancy and lactation (breastfeeding) is contraindicated.

Use in children

special instructions

It is not advisable to co-administer Lykopid with sulfa drugs and tetracyclines.

Impact on the ability to drive vehicles and operate machinery

The use of the drug Likopid ® does not affect the ability to perform work that requires increased attention and speed of psychomotor reactions.

Immunomodulatory medications are designed to strengthen protective forces body to prevent viral, fungal or bacterial diseases. If an infection does appear, they help to cope with it faster. One of the drugs in this group is Lykopid. Is it used in childhood and is it prescribed for prevention for children?

Composition and release form

The medication is available only in solid form, which is white, flat, round tablets. They are sold in packs of 10 pieces, packed in one blister. Lykopid does not have such forms as syrup, suspension, ointment, capsules or injections.

The active component in such tablets is a compound called “glucosaminylmuramyl peptide”. Its dosage in each tablet is 1 mg. Additionally, the preparation contains lactose monohydrate and methylcellulose, as well as calcium stearate, potato starch and sucrose.

Operating principle

Main component Lykopida, due to which the drug has an immunomodulatory effect, has the same structure as that of bacterial cell walls.

Once in the human body, such a compound activates both acquired and innate immunity, resulting in increased protection against harmful microbes, fungi and viruses. It binds to proteins that are located inside macrophages, neutrophils and other phagocytes, which leads to an increase in the functional activity of such cells. This also activates the formation of B and T lymphocytes, antibodies, interleukins and other factors important for immune defense.

Indications

In childhood, Lykopid is in demand:

• as a means of treatment chronic respiratory tract infections (bronchitis, sinusitis, adenoiditis, laryngitis, etc.), as well as prophylactic, prescribed in the remission stage to prevent relapses of such diseases;
• for furunculosis, pyoderma and other purulent-inflammatory diseases m soft fabrics and skin. The medicine is also used for acute process, and for treatment chronic forms such diseases;
• For herpes infection, for example, with a sore throat caused by the herpes virus, eye damage or a “cold” on the lips.

For adults, tablets can also be prescribed to prevent infection with ARVI as the season approaches. respiratory diseases. However, in children, according to the instructions for the tablets, this prophylactic appointment not used.

At what age is it allowed to take it?

Children are prescribed only a drug containing the active ingredient in a dose of 1 mg. He is discharged from the age of 3 years. Tablets in which the active compound is presented in a dosage of 10 mg are not used under 18 years of age.

Contraindications

Likopid should not be given to a child:

• with hypersensitivity to any ingredient of the drug;
• with exacerbation autoimmune thyroiditis, as well as with others autoimmune pathologies;
• with a temperature above +38 degrees;
• With metabolic disorders, in which you should not consume lactose and sucrose.

Side effects

The manufacturer calls Likopid a non-toxic drug and assures that such a medication does not harm the central nervous system and cardiovascular system, and also does not provoke mutations or changes in internal organs.

However, some children may experience an increase in body temperature when starting to use the medicine. Often this is a short-term rise to low-grade levels, but sometimes the fever is febrile. In such a situation, the child is prescribed one of the antipyretic drugs, and there is no need to stop Likopid.

Also, in extremely rare cases, taking pills provokes diarrhea.

Instructions for use

The child is asked to keep the tablet under the tongue or swallow it half an hour before meals. Single dose for childhood is one tablet, and the method and mode of administration depends on the disease:

• For chronic infection respiratory tract, the medicine is dissolved under the tongue, one tablet per day for 10 days. To eliminate relapses, the medication is prescribed in three courses with a break of 20 days.
• For inflammatory-purulent skin pathologies or soft tissues, the medicine also needs to be taken only once a day, dissolving the tablet in oral cavity. Duration of treatment – ​​10 days.
• When infected with herpes, Lykopid can be either kept in the mouth or swallowed. In this case, the medicine is taken three times a day, and the course of treatment lasts 10 days.

It is best to take the medication at the same time. If for some reason the next dose was missed, but less than 12 hours have passed since the time when Lykopid should have been taken, the child is given the missed pill. Then continue to take the medication according to the prescribed regimen.

If a missed dose is detected after 12 hours or later, you do not need to take the missed drug.

In such a situation, the medicine is taken according to the original regimen without missing a dose.