Riboxin injection intravenously. Riboxin (solution for injection): instructions for use. Features of use for various diseases

The medication restores blood circulation in the coronary vessels and increases the energy balance of the heart muscle. Thanks to these properties, the drug is used not only to improve the functionality of the heart and digestive organs, but also to increase endurance and physical fitness.

Description of the dosage form

The main component of the drug is inosine. In appearance, it is a white or yellowish powder with a neutral odor and bitter taste.

Riboxin solution is administered intramuscularly and intravenously

Riboxin injections contain the following substances:

The injection solution (2%) is injected into a vein or muscle. The colorless liquid is packaged in ampoules of 5 and 10 ml.

Properties of the drug

Riboxin is an anabolic drug that has antihypoxic and antiarrhythmic effects. Inosine is a chemical precursor of adenosine triphosphate; it is involved in glucose metabolism and stimulates metabolic processes against the background of hypoxia.

The solution has an antihypoxic and antiarrhythmic effect

The components of the injection solution stimulate the metabolism of pyruvic acid, as a result, cellular respiration is normalized even with ATP deficiency. After administration of the drug, its components act on enzymes that participate in metabolic processes. They activate xanthine dehydrogenase, which converts hypoxanthine into uric acid. The solution exhibits a therapeutic effect faster than Riboxin tablets.

Inosine inhibits the process of platelet adhesion, as a result, the likelihood of thrombus (blood clot) formation in the lumen of the vessel decreases. This is a kind of prevention of thrombosis and thromboembolism (blockage of a blood vessel with a thrombus). Under the influence of the drug, the processes of regeneration of myocardial tissue and the internal membranes of the digestive organs are launched.

After intravenous administration, the drug enters the tissues that need ATP. Residues of the drug are excreted in urine, feces, and bile.

Pros and cons of the medication

The advantages of Riboxin include the effect of inosine on metabolic processes in the heart muscle. The drug increases the energy balance of heart muscle cells, accelerates the formation of nucleoside phosphates (phosphorus esters of nucleosides), as a result, the regeneration of heart tissue is accelerated. The drug normalizes the contractile activity of the heart muscle and the complete course of diastole (relaxation of the myocardium between contractions).

The disadvantages of Riboxin include its ability to change the natural sequence of the metabolic cycle. This means that inosine, coming from outside, corrects metabolic processes. Doctors try not to interfere with human physiology, since the medicinal properties of drugs can provoke dangerous complications. But if there is a pathological process in the body that causes destructive changes in the myocardium, then it is simply necessary to change the metabolism. Without intervention, the likelihood of death increases.

Riboxin is prescribed for ischemia, arrhythmia, porphyria, cirrhosis, etc.

Purpose of Riboxin

According to the instructions for using Riboxin in ampoules, the medication has the following indications:

• Cardiac ischemia (complex therapy). The drug is used regardless of the stage of the disease, as well as during recovery after a heart attack.
• Primary myocardial damage of unknown etiology. Then Riboxin is used for a long time.
• For arrhythmia, the drug helps normalize the heart rhythm. The best effect can be achieved during the treatment of a disease that arose as a result of an overdose of medications.
• Congenital porphyria.
• Cirrhosis, steatosis (replacement of liver cells with fatty tissue), hepatitis, etc. For these diseases, Riboxin is used as part of complex therapy.
• Open-angle glaucoma (complex therapy).
• Radiation therapy is also an indication for use. The medicine makes the procedure easier to perceive and reduces the severity of adverse reactions.
• Prolonged intense physical activity, which negatively affects the general condition.
• Pregnant women are prescribed the drug exclusively by the attending physician, who then monitors the patient’s condition.

These are the main indications for the use of the drug.

A prescription is not required to purchase Riboxin.

Precautionary measures

The instructions for using injections state that the medication is prohibited from being taken in the following cases:

• Intolerance to inosine and other components of the drug.
• Gouty arthritis.
• Increased concentration of uric acid in the blood.
• During pregnancy and breastfeeding.
• Patients younger than 12 months.

Riboxin in the form of a solution is contraindicated in case of gout, pregnancy, breastfeeding, hypersensitivity to components

In case of functional renal failure, the drug is used when the possible benefit outweighs the potential risk. The decision to prescribe medication is made solely by the attending physician.

During the period of therapy, you need to regularly take blood tests. This is necessary in order to control the concentration of uric acid.

The medicine is not prescribed to patients in the younger age category due to the lack of information about its safety. The reaction of a child's body to the drug is unpredictable, so it is not worth the risk.

Riboxin does not cause drowsiness, for this reason it is used before activities related to concentration.

Typically, patients tolerate the effect of the solution well, but sometimes it still provokes negative reactions:

• decreased blood pressure;
• increased concentration of urea and its salts;
• cardiopalmus;
• rash on the skin that itches;
• skin redness;
• nettle fever;
• general weakening of the body;
• with long-term therapy, gout worsens.

Drug interactions

Riboxin interacts with other medications in different ways:

• β-adrenergic receptor blockers. Riboxin can be combined with drugs from this group.
• Cardiac glycosides. This combination prevents arrhythmia and makes the inotropic effect more pronounced. Riboxin enhances the effect of heparin for a long time. Nitroglycerin, Nifedipine, Furosemide, Spironolactone can be combined with Riboxin.
• Alkaloids. This is a clear example of incompatibility, when substances react, the alkaloid base is separated, resulting in the formation of insoluble compounds.
• Tannin. When combined, a precipitate forms.
• Acids, alcohols, heavy metal salts. Complete incompatibility.
• Pyridoxine (vitamin B6). Should not be used together, as both compounds are deactivated.

Any combination of Riboxin with other drugs is created by the attending physician

Solution dosage

Riboxin in ampoules is administered intramuscularly and intravenously. Quick jet injections are administered in a minimum dosage - 10 ml of solution (2%) once. Then, if the patient tolerated the medicine well, the dose is increased to 20 ml 1 or 2 times a day. The therapeutic course lasts from 10 to 15 days. The dose of medication is increased only if the patient tolerates Riboxin well.

For acute heart rhythm disorders, 10 to 20 ml of solution is administered once.

To protect kidneys affected by ischemia, the medicine is administered using a syringe in a dosage of 60 ml 10-15 minutes before the doctor clamps the renal artery. Then it is necessary to administer another 40 ml of the medicine immediately after the resumption of blood circulation.

Parenteral administration is a method of administering a solution using a dropper. Before administering the solution, it must be mixed with glucose (5%) or 250 ml of sodium chloride. The rate of administration of the medicine by the drip method is from 40 to 60 drops per minute.

Riboxin during pregnancy and lactation

According to the instructions for use, Riboxin is prohibited from use during pregnancy and breastfeeding. However, despite this, doctors prescribe the drug to expectant and new mothers. Many women are afraid to take medicine so as not to harm the child. But according to doctors, therapeutic doses of the drug will only bring benefits.

The drug improves metabolism and energy supply to tissues, that is, the body of the woman and fetus is more actively saturated with useful substances during their deficiency. This is one of the main advantages of Riboxin.

During pregnancy, a woman often suffers from oxygen deficiency. This is a very dangerous condition, since during pregnancy the respiratory organs of the expectant mother must provide oxygen not only to her body, but also to the body of the fetus. Often the lungs and bronchial tree are not able to saturate two organisms with oxygen. Riboxin has an antihypoxic effect; the drug minimizes the effects of oxygen starvation and saturates the body with the necessary gas.

Riboxin injections are taken during pregnancy and breastfeeding only under the supervision of a doctor.

The drug restores normal contractile activity of the heart muscle. The medication regulates the metabolism of myocardial muscle cells and stimulates trophic processes. That is why Riboxin is used to prevent arrhythmia, tachycardia and other disorders of myocardial functionality.

Riboxin for animals

The pharmaceutical origin of Riboxin is non-specific, for this reason it is used in veterinary medicine. The drug is often prescribed to treat heart disease in cats and dogs. In this case, the medication has the following indications:

• Functional heart failure.
• Myocarditis.
• Endocarditis.
• Myocardosis (to improve the metabolic abilities of the heart).
• Heart defects.

These are the most common heart problems in older animals.

The solution is administered intramuscularly, as this is the most rational method of administration for animals. The daily dosage of the drug is from 100 to 200 mg/10 kg of total weight three times. The therapeutic course lasts no longer than 4 weeks. If necessary, the veterinarian will prescribe a second course in order to more thoroughly adjust the metabolism or eliminate severe degenerative changes.

Patients about Riboxin

Many patients and doctors speak well of the effect of the liquid dosage form of Riboxin. Usually the drug is well tolerated by patients and has a wide spectrum of action. The medication has a beneficial effect on the heart muscle, stomach, and intestines.

“My grandmother, who suffered 2 heart attacks, used Riboxin as prescribed by a cardiologist. I was prescribed medication after mitral valve prolapse was discovered. I administer the solution in the dosage indicated by the doctor in courses. I carry out treatment twice a year. I am satisfied with the effect of the drug. Riboxin improves not only the functionality of the heart, but also the liver. I recommend the drug to everyone to whom a doctor prescribed it. Use the medicine, as the consequences of the disease can be very dangerous. I didn’t find any side effects during treatment.”

“About 4 months ago, interruptions in the functioning of the heart appeared, which were manifested by rapid heartbeat, tremors in the chest, followed by a pause. In addition, there was shortness of breath, weakness, dizziness, my vision was getting dark, and several times I felt like I was about to lose consciousness. These symptoms scared me very much, so I went to the hospital. After examination, the cardiologist diagnosed extrasystolic arrhythmia and prescribed Riborxin. First, I administered the solution intravenously, 5 ml once for 2 days. Then the portion of the medicine was increased to 10 ml once a day for 10 days. After using the solution, I was prescribed tablets, which I used for 3 months. I felt an improvement after just a week of using Riboxin. Now the heart is working normally. By the way, there were no side effects during the therapeutic course.”

“I was prescribed Riboxin during pregnancy, as I had hypoxia and my heart was not working properly. The doctor prescribed injections, which were administered to me for 10 days. After treatment, my condition improved significantly. The child was born healthy, and my allergies did not manifest themselves during treatment. So I recommend it to expectant mothers if the doctor recommends such treatment.”

Based on all of the above, Riboxin solution is an effective drug that exhibits antihypoxic and antiarrhythmic effects. The drug has a beneficial effect on the functionality of the myocardium, as well as the digestive tract. To avoid side effects, the medicine is used only for medical reasons, and the patient must strictly follow all doctor’s recommendations regarding its use.

Riboxin in ampoules

Manufacturer: Arterium (Arterium) Ukraine

ATS code: C01EB14

Release form: Liquid dosage forms. Injection.

General characteristics. Compound:

1 ml of solution contains inosine 20 mg;

excipients: hexamethylenetetramine, 1 M sodium hydroxide solution, water for injection.

Pharmacological properties:

Pharmacodynamics. Riboxin is an anabolic drug that has antihypoxic and antiarrhythmic effects. It is a precursor of ATP, is directly involved in glucose metabolism and promotes metabolism activation under hypoxic conditions and in the absence of ATP. The drug activates the metabolism of pyruvic acid to ensure the normal process of tissue respiration and promotes the activation of xanthine dehydrogenase. Riboxin has a positive effect on metabolism in the myocardium, in particular, it increases the energy balance of cells, stimulates the synthesis of nucleotides, and increases the activity of a number of Krebs cycle enzymes. The drug normalizes the contractile activity of the myocardium and promotes complete relaxation of the myocardium in diastole due to the ability to bind calcium ions that penetrated the cells during their excitation, and activates tissue regeneration (especially the myocardium and the mucous membrane of the digestive canal).

Pharmacokinetics. When administered intravenously, Riboxin is quickly distributed in tissues, metabolized in the liver, where it is completely utilized in the biochemical reactions of the body. Excreted mainly in urine.

Basic physical and chemical properties: transparent, colorless liquid.

Incompatibility. The drug should not be mixed with other drugs in the same syringe or in the same infusion system. Use only recommended solvents.

Indications for use:

Complex treatment of coronary heart disease (condition after myocardial infarction, angina pectoris), heart rhythm disturbances, intoxication with cardiac glycosides, treatment of cardiomyopathies of various origins, myocardial dystrophies (due to heavy physical exertion, infectious and endocrine origin), myocarditis; liver diseases (hepatitis, liver cirrhosis, fatty liver); prevention of leukopenia during irradiation. To improve visual function in open-angle glaucoma with normalized intraocular pressure.

Directions for use and dosage:

Apply intravenously by drip or stream. First, 200 mg (10 ml of a 2% solution) is administered once a day, then, if well tolerated, up to 400 mg (20 ml of a 2% solution) 1-2 times a day. The course of treatment is determined individually (on average per day).

When administered drip into a vein, a 2% solution of the drug is diluted in a 5% glucose solution or 0.9% sodium chloride solution (up to 250 ml). The drug is administered drip-wise slowly, at a drop rate of 1 minute. In case of acute cardiac arrhythmias, a single dose of jet injection (10-20 ml of 2% solution) is possible.

Adverse reactions. Patients with hypersensitivity to the drug may experience allergic reactions (itching, skin flushing, rash, urticaria). From the cardiovascular system: arterial hypotension, tachycardia are possible. Various local reactions and general weakness may occur.

In rare cases, during treatment, an increase in the level of uric acid in the blood may occur, and with prolonged treatment, an exacerbation of gout may occur.

Features of application:

In case of renal failure, the use of the drug is possible only when, in the opinion of the doctor, the expected positive effect exceeds the possible risk of use.

During treatment, the level of uric acid in the blood should be regularly monitored.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. No data.

Side effects:

If adverse reactions occur, the drug should be discontinued.

Interaction with other drugs:

With simultaneous use of Riboxin with beta blockers, the effect of Riboxin does not decrease. In combination with cardiac glycosides, the drug can prevent the occurrence of arrhythmias and enhance the inotropic effect. Riboxin can enhance the effects of heparin, increasing the duration of its action. Possible simultaneous use with nitroglycerin, nifedipine, furosemide, spironolactone. Incompatible with alkaloids in the same container: upon interaction, the alkaloid base is separated and insoluble compounds are formed. Forms sediment with tannin. Incompatible with acids and alcohols, salts of heavy metals. Incompatible with vitamin B6 (pyridoxine hydrochloride) due to deactivation of both compounds.

Contraindications:

Increased individual sensitivity to the drug. Gout, hyperuricemia. A limitation to the use of Riboxin is renal failure.

Use during pregnancy or breastfeeding. Studies of the effectiveness and safety of use for this group of patients have not been conducted.

Children: Should not be used in children due to lack of safety data.

Overdose:

Individual intolerance to the drug in the form of itching, skin hyperemia is possible (the drug is discontinued and desensitizing therapy is carried out).

Storage conditions:

Shelf life: 3 years. In a place protected from light at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Vacation conditions:

Package:

5 ml or 10 ml per ampoule; 10 ampoules per box. 5 ml or 10 ml per ampoule; 5 ampoules in a blister; 2 blisters per pack.

Riboxin

Description current as of 10/28/2014

• Latin name: Riboxin
• ATX code: C01EV
• Active ingredient: Inosine
• Manufacturer: Binnopharm ZAO (Russia); Asfarma (Russia); Ozon LLC (Russia); Irbit Chemical Pharmaceutical Plant (Russia); Borisov Medical Preparations Plant (Republic of Belarus).

Compound

1 tablet of the pharmaceutical product contains:

• Riboxin – 0.2 g;
• Calcium stearate;
• Potato starch;
• Powdered sugar;
• Opadry II Yellow coating mixture - Indigo carmine (E 132), Lactose monohydrate, Titanium dioxide (E 171), Macrogol (polyethylene glycol 3000), Quinoline yellow (E 104), Iron oxide (E 172).

Composition of solution for injection:

Release form

• 2% solution for injection in ampoules of 10 ml (total content of the main active ingredient – ​​200 mg). The cardboard box holds 10 ampoules.
• Riboxin tablets are yellow, coated with a biconvex surface. In the cross section, two layers are clearly visible. The drug is packaged in contour cellular blisters made of aluminum foil or PVC, 10 tablets each. A pack contains 1, 2, 3, or 5 plates.
• Riboxin Lect - capsules containing Inosine - 0.2 g. 20, 30 or 50 pieces are placed in a cardboard package.

pharmachologic effect

What is Riboxin?

Riboxin is an anabolic drug that has nonspecific antihypoxic and antiarrhythmic effects. The main active component of the drug is Inosine (Inosine - INN or international nonproprietary name of pharmaceutical products) - a chemical precursor of adenosine triphosphate (ATP), which is directly involved in the metabolism of glucose and promotes the activation of metabolic processes in conditions of oxygen deficiency (“oxygen starvation”).

Mechanism of action of the drug

The biologically active substances included in the drug activate the metabolism of pyruvic acid (PVA), which ensures the normalization of tissue respiration even in the absence of the required amount of ATP. The active components also affect the enzymatic component of metabolic processes - when they enter the human body, they stimulate the activity of xanthine dehydrogenase, which in turn catalyzes oxidative reactions with the subsequent formation of uric acid from hypoxanthine.

The benefits and harms of Riboxin

The positive effects of the pharmaceutical drug include the effect of the main components of Riboxin on metabolism in the myocardium (heart muscle). Thus, the therapeutic properties of the drug are manifested in an increase in the energy balance of cardiomyocytes, accelerated formation of nucleotides, which is manifested in enhanced processes of physiological regeneration of cardiac tissue. That is, the medicine helps to normalize the contractile activity of the myocardium and a more complete course of diastole, when the heart completely relaxes due to the ability to bind with chemical chains of calcium ions that penetrate into the intracellular space during systole.

The negative effects of Riboxin include a change in the physiological sequence of the metabolic cycle. That is, the active components of a pharmaceutical drug, coming from outside, make adjustments to metabolic processes. As a rule, qualified specialists try, if possible, not to interfere in this area of ​​biochemistry of the human body, since therapeutic effects can cause very adverse consequences for the patient. However, in the presence of a pathological process that destructively affects the heart muscle (the vital “pump” of the circulatory system), a change in metabolism is necessary, because non-intervention will lead to a much worse outcome.

Wikipedia about Riboxin

The free encyclopedia of knowledge on the Internet also reveals some aspects of the pharmacological action of the drug. In particular, all the cardiac effects of the biologically active components that make up Riboxin are described. In addition, on the page about this medicine there is information about the effect on the cellular component of the blood coagulation system - Inosine reduces platelet aggregation, thereby reducing the risk of developing thrombosis and thromboembolism. The regenerative therapeutic properties of the pharmaceutical drug extend not only to the heart muscle, but also to the mucous membrane of the gastrointestinal tract.

Separately, it should be noted that Inosine pranobex is a type of drug that has immunostimulating activity and a nonspecific antiviral effect. The drug suppresses such harmful pathogens as herpes simplex virus, CMV (cytomegalovirus), measles and T-cell lymphoma virus type 3, human enterocytopathogenic virus and many others. The mechanism of this action lies in the inhibition of ribonucleic acid and inhibition of the biological catalyst dihydropteroate synthetase, which manifests itself in the suppression of viral replication and increased production of interferons by lymphocytes that destroy pathological organisms.

Pharmacodynamics and pharmacokinetics

When taken orally, Riboxin is well and almost completely absorbed from the gastrointestinal tract. When administered intravenously, the pharmaceutical drug is quickly distributed into tissues that need ATP. Regardless of the route of administration, unused active ingredients are metabolized in the liver, where the final stages of metabolic biochemical reactions take place. A small amount of Riboxin is excreted in urine, feces and bile.

Indications for use of Riboxin

Indications for use of Riboxin tablets:

• Complex treatment of coronary heart disease (angina pectoris, coronary insufficiency, condition after myocardial infarction);
• Intoxication with cardiac glycoside drugs;
• Cardiomyopathies of various origins;
• Myocarditis;
• Rheumatic, congenital and acquired heart defects;
• Cardiac arrhythmia;
• Myocardial dystrophy of infectious or endocrine origin (especially against the background of heavy physical exertion);
• Coronary atherosclerosis;
• Nonspecific liver diseases (hepatitis, fatty degeneration of the parenchymal organ, cirrhosis);
• Drug and alcohol liver damage;
• Urocoproporphyria;
• Prevention of a decrease in the number of leukocytes during irradiation;
• Peptic ulcer of the stomach and duodenum;
• Open-angle glaucoma with normalized intraocular pressure.

Specific indications for the use of injections:

• Urgent pathological conditions of cardiac arrhythmias;
• Surgeries on an isolated kidney (as a means of pharmacological protection in case of temporary absence of blood circulation);
• Arrhythmias of unknown etiology in medicine;
• Acute radiation exposure to prevent the development of changes in the blood formula.

Contraindications

• Hereditary or acquired intolerance to the constituent components of a pharmaceutical drug;
• Individual hypersensitivity to the active ingredients of the drug;
• Gout;
• Kidney failure;
• Hyperuricemia (increased amount of uric acid salts in the blood).

Side effects

As a rule, the medicine is well tolerated, only in isolated cases the following side effects are observed:

Instructions for use of Riboxin (Method and dosage)

Riboxin tablets, instructions for use

Tablets are used orally, before meals. The dosage, as a rule, is set individually in view of the characteristics of the metabolism of the active components and indications for conservative therapy. However, there are certain general treatment regimens for this pharmaceutical drug, according to which the daily dose for adults and children over 12 years of age is 0.6-2.4 g per day. Sanitation begins with small dosages (about 0.6-0.8 g - 1 tablet 3-4 times a day), and then, if the medicine is well tolerated and has a beneficial effect on the body, the dose is gradually increased over 2-3 days .

The maximum amount of the drug taken is 2.4 g per day - 4 tablets 3 times per day. This dosage is achieved for 2 months of a course of conservative treatment, the entire duration of which, as a rule, lasts from 1 to 3 months and is adjusted taking into account individual indications for therapeutic intervention.

Separately, it should be noted how to take tablets for urocoproporphy, since the pathophysiology of this disease is associated with an increase in uric acid salts in biological fluids and secretions. Riboxin, in turn, accelerates the metabolism of urates, activating the enzymatic oxidation of hypoxanthine. Therefore, in order to avoid deposits and the formation of stones, the dosage of the drug is 0.8 g per day - 1 tablet 4 times a day and must be strictly observed during conservative treatment.

Riboxin injections, instructions for use

Slow drip parenteral administration or rapid jet injections are used, depending on individual indications and the urgency of the pathological condition. If the attending physician chooses injections, then first apply a minimum dosage of 200 mg of Riboxin (10 ml of 2% injection solution) once a day. In case of acute cardiac arrhythmias, a single dose of Inosine (10-20 ml of 2% solution) intravenously can be used.

The dosage of jet administration is increased only if the drug is well tolerated. The maximum amount of the drug can be 400 mg of Riboxin (two ampoules of a 2% solution) 1 or 2 times a day. The duration of the course is selected individually (according to the general protocol - days).

If you use Riboxin intravenously (intravenously), then before its administration, a 2% solution of the drug must be diluted in 5% glucose or a hypotonic sodium chloride solution (concentration - 0.9%) to obtain 250 ml of medicinal liquid. The rate of administration is drops per minute.

Instructions during pregnancy

Riboxin is used intravenously for pregnant women, because in this way its effects are revealed more fully. The dosage and duration of the course of conservative therapy is selected strictly individually in each individual case, based on the results of various clinical studies and the opinion of qualified specialists.

How to use Riboxin Lect?

The dosage and duration of treatment with this variation of the pharmaceutical drug do not differ from the generally accepted protocols for therapeutic care with Riboxin. However, the Lect form of the drug is not used as an emergency correction of dysfunction of the heart muscle or other organs, since its effects develop somewhat more slowly.

Overdose

The medical pharmacological literature does not describe cases of overdose with this pharmaceutical drug.

Interaction

The combined use of a drug with cardiac glycosides enhances the inotropic effect of the latter and prevents the development of such adverse consequences of drug treatment as the occurrence of arrhythmia, for which Riboxin is sometimes prescribed together with this group of pharmaceuticals.

Simultaneous use of Riboxin with anticoagulants such as heparin increases the duration of their therapeutic action.

The drug is completely incompatible with acids and alcohols, pyridoxine hydrochloride or vitamin B6, since both chemical compounds are deactivated, heavy metal salts, and plant alkaloids. The latter, when interacting with Riboxin, form insoluble and non-removable compounds due to the detachment of the alkaloid base.

Terms of sale

The drug belongs to list B, therefore it can be purchased only upon presentation of a certified receptor form. Certain old-fashioned pharmacy stalls may even require a prescription in Latin.

Storage conditions

The medicine should be stored in its original packaging at a temperature not exceeding 25 degrees Celsius in a dry place inaccessible to young children. Also, the drug should be protected from exposure to direct sunlight.

Best before date

special instructions

Riboxin in bodybuilding

The pharmaceutical drug is classified as a metabolic agent and biochemical stimulant, so the drug can be used to gain weight, improve physical performance and increase strength. Riboxin was actively used in sports back in the 70s. The following types of nutrition for bodybuilders are known, which are actively sold to this day:

• Premium Inosine;
• Ultimate nutrition;
• Inosine mega-pro;
• Inosine life extension;
• Cell-tech hardcore.

How to take Riboxin for bodybuilding?

In sports nutrition, a tablet form of the drug is used, which is administered orally before meals. The dosage ranges from 1.5 to 2.5 g per day. As for therapeutic purposes, the number of tablets taken should be gradually increased from a starting dosage of 0.6-0.8 g 3-4 times a day to 2.5 g. Riboxin for athletes should be used for 4 weeks to 1.5 -3 months.

To enhance the effect of the drug on the myocardium and reduce the period of mid-mountain and climatic adaptation, Potassium orotate and Riboxin can be used together. In this case, the dosage of the potassium salt of orotic acid is 0.25-0.5 g 2-3 times a day before meals (course duration is days), and Riboxin is used according to the above scheme.

Riboxin in veterinary practice

The drug is non-specific in its pharmaceutical nature, therefore it can also be used in veterinary therapeutic practice. Often the drug is used for dogs to eliminate heart failure, treat myocarditis and endocarditis, improve the metabolic abilities of the muscular organ with myocardosis and heart defects, which are very common senile problems in animals.

How should animals take Riboxin?

As a rule, the drug is administered intramuscularly, because this is the most rational route of administration in veterinary practice. The dosage is 0.1-0.2 g of the drug per 10 kg of animal weight 3 times a day. The course of conservative treatment lasts about a month. Repeated prescriptions of Riboxin are possible for a more thorough correction of metabolism or elimination of deep degenerative changes.

Riboxin's analogues

Riboxin analogues constitute a small pharmaceutical group with an identical main active ingredient - Inosie-F, Inosine, Riboxin bufus, Ribonosine. As a rule, the price of these drugs is even lower, which is why Riboxin tablets can be replaced with these analogues for greater savings.

With alcohol

Riboxin IV (intravenously) should not be combined with drinking alcohol, as this is fraught with side effects from the list above or the emergence of new adverse consequences of conservative therapy with a pharmaceutical drug.

Riboxin during pregnancy (and lactation)

The pharmaceutical drug is actively prescribed during the most critical periods for a woman, which, as a rule, plunges expectant mothers into slight bewilderment. Even after reading the instructions, many questions remain, the main one of which, of course, is what Riboxin is for during pregnancy. The drug improves energy supply and tissue metabolism, that is, it provides the woman and fetus with a more active supply of beneficial nutrients during the period when they suffer from deficient conditions. This is one of the main aspects of using Riboxin.

Also, the active ingredients help reduce harm from the so-called “oxygen starvation,” which is a common complication during pregnancy. A pathological condition occurs because the woman’s respiratory system supplies two organisms with vital gas. But such a powerful need for oxygen runs counter to the capabilities of the lungs and bronchial tree. Therefore, the antihypoxic effect of Riboxin comes in handy, and this is the second, but no less important aspect of using the drug during pregnancy.

Among the therapeutic properties of a pharmaceutical drug, a significant part consists of effects on cardiac activity. Riboxin normalizes myocardial contractile activity, regulates the metabolic needs of cardiomyocytes, and helps enhance trophic processes. Thus, the drug plays the role of preventive sanitation, since it is not uncommon for pregnant women to develop pathological processes such as arrhythmias, tachycardias and other disturbances in the rhythm of the heart muscle.

How to take Riboxin for pregnant women?

The dosage and duration of use of a pharmaceutical drug during pregnancy is always selected individually based on diagnostic test results, ultrasound data and other physiological parameters. As a rule, Riboxin is administered intravenously during pregnancy, but in the medical literature and on thematic forums for pregnant women, cases of prescribing the tablet form of the drug are described.

Riboxin

Composition and release form Riboxin

Film-coated tablets:
1 tablet contains 0.2 g of inosine;
10, 20, 30, 40, 50 pcs. packaged.
Solution for injection 2%:
1 ml of solution contains 20 ml of inosine;
in ampoules of 5 or 10 ml, in a package of 10 ampoules.

Pharmacotherapeutic group: Riboxin

A drug that improves metabolism and energy supply to tissues, reducing tissue hypoxia.

Pharmacological action of Riboxin

It is a derivative of purine. Inosine can be considered as a precursor to ATP. Has an anabolic effect. Activates myocardial metabolism. Inosine increases the activity of a number of Krebs cycle enzymes and stimulates the synthesis of nucleotides. Inhibits the process of destruction of the sarcolemma of ischemic cardiomyocytes and ensures intracellular energy transport. By improving microcirculation, the drug reduces the size of the zone of necrosis and myocardial ischemia.

Pharmacokinetics of Riboxin

Well absorbed in the digestive tract. It is destroyed in the liver with the formation of glucuronic acid and its subsequent oxidation. A small amount is excreted in the urine.

Indications Riboxin

Riboxin is prescribed to adults in the complex treatment of coronary heart disease, myocardial dystrophy, after myocardial infarction, and cardiac arrhythmias caused by the use of cardiac glycosides.
Prescribed for hepatitis, cirrhosis, fatty liver caused by alcohol or drugs, and urocoproporphyria.
As a means of pharmacological protection of the kidneys from ischemia during temporary disconnection of the kidney from the blood circulation.
The drug improves visual function in open-angle glaucoma with intraocular pressure normalized under the influence of antihypertensive therapy.

Contraindications Riboxin

Hypersensitivity to the drug.

Method of administration and dosage of Riboxin

Riboxin is prescribed orally before meals.
In the first days of treatment, Riboxin is prescribed 1 tablet. 3-4 times a day (600-800 mg). If well tolerated, the dose of the drug is increased over 2-3 days to 1.2-2.4 g per day. The duration of the course of taking the drug is 4-15 weeks.
For urocoproporphyria Riboxin is prescribed 1 tablet. 4 times a day. Duration of treatment is 1-3 months.

Riboxin solution 2% is used intravenously. Administer slowly in a stream or drip (40-60 drops per minute).
Treatment begins with the administration of 10 ml (200 mg) once a day. If well tolerated, the dose can be increased to 20 ml (400 mg) 1-2 times a day. Duration of treatment is 10-15 days.
For drip administration, dilute the Riboxin solution in an isotonic sodium chloride solution or 5% glucose solution to 250 ml.

Side effects of Riboxin

Possible allergic reactions in the form of urticaria, skin itching, skin hyperemia (the drug is discontinued).
Rarely: increased concentration of uric acid in the blood.
With long-term use: Possible exacerbation of gout.

Special instructions Riboxin

Riboxin is not used for emergency correction of cardiac dysfunction.

Drug interactions Riboxin

When used as part of complex therapy, Riboxin helps to increase the effectiveness of antiarrhythmic, antianginal and inotropic drugs.
Clinically significant interactions of Riboxin with drugs from other groups have not been described.

Storage conditions for Riboxin

List B. In a dry place, protected from light, at room temperature. Keep out of the reach of children.

Riboxin

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Composition and release form of the drug

Solution for intravenous administration in the form of a transparent, colorless or slightly colored liquid.

Excipients: propylene glycol - 1 mg, anhydrous sodium sulfite - 1 mg, acetic acid diluted 30% - to pH 7.8 - 8.6, water for injection - up to 1 ml.

5 ml - ampoules (5) - contour cell packaging (1) - cardboard packs.
5 ml - ampoules (5) - contour cell packaging (2) - cardboard packs.
10 ml - ampoules (5) - contour cell packaging (1) - cardboard packs.
10 ml - ampoules (5) - contour cell packaging (2) - cardboard packs.

pharmachologic effect

Purine nucleoside, precursor of ATP. Improves myocardial metabolism, has antihypoxic and antiarrhythmic effects. Increases the energy balance of the myocardium. Has a protective effect on the kidneys in conditions of ischemia during surgery.

Participates in metabolism, increases the activity of a number of Krebs cycle enzymes. Stimulates nucleotide synthesis.

Pharmacokinetics

Inosine is well absorbed from the gastrointestinal tract. Metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation. A small amount is excreted by the kidneys.

Indications

IHD, myocardial dystrophy, condition after myocardial infarction, congenital and cardiac arrhythmias, especially with glycoside intoxication, myocarditis, dystrophic changes in the myocardium after heavy physical exertion and previous infectious diseases or due to endocrine disorders; hepatitis, cirrhosis of the liver, incl. caused by alcohol or drugs; prevention of leukopenia during radiation exposure; operations on an isolated kidney (as a means of pharmacological protection in case of temporary absence of blood circulation in the operated organ).

Contraindications

Dosage

When taken orally, the initial daily dose is 600-800 mg, then the dose is gradually increased to 2.4 g/day in 3-4 doses.

For intravenous (stream or drip) administration, the initial dose is 200 mg 1 time/day, then the dose is increased to 400 mg 1-2 times/day.

You can ask a question or leave a review about the medicine (please, do not forget to indicate the name of the drug in the text of the message).

Preparations containing Inosine (Inosine, ATC code not assigned, group C01EB)

Riboxin (Inosine) - instructions for use. The drug is a prescription, the information is intended only for healthcare professionals!

Clinical and pharmacological group:

A drug that normalizes myocardial metabolism and reduces tissue hypoxia

pharmachologic effect

Inosine belongs to the group of drugs that regulate metabolic processes. The drug is a precursor for the synthesis of purine nucleotides: adenosine triphosphate and guanosine triphosphate.

It has antihypoxic, metabolic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, and prevents the consequences of intraoperative renal ischemia. It is directly involved in glucose metabolism and promotes the activation of metabolism under conditions of hypoxia and in the absence of adenosine triphosphate.

Activates the metabolism of pyruvic acid to ensure the normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of some Krebs cycle enzymes. Penetrating into cells, it increases the energy level, has a positive effect on metabolic processes in the myocardium, increases the strength of heart contractions and promotes more complete relaxation of the myocardium in diastole, resulting in an increase in stroke volume of blood.

Reduces platelet aggregation, activates tissue regeneration (especially the myocardium and the mucous membrane of the gastrointestinal tract.

Pharmacokinetics

Well absorbed in the gastrointestinal tract. Metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation. A small amount is excreted by the kidneys.

Indications for use of the drug RIBOXIN

Prescribed to adults in the complex treatment of coronary heart disease, after myocardial infarction, cardiac arrhythmias caused by the use of cardiac glycosides.

Prescribed for hepatitis, cirrhosis, fatty liver caused by alcohol or drugs and urocoproporphyria.

Dosage regimen

When administered intravenously (stream or drip), the initial dose is 200 mg 1 time per day, then the dose is increased to 400 mg 1-2 times per day.

The duration of the course of treatment is determined individually.

When taken orally, it is prescribed to adults, before meals.

The daily dose when taken orally is 0.6-2.4 g. In the first days of treatment, the daily dose is 0.6-0.8 g (200 mg 3-4 times a day). If well tolerated, the dose is increased (on days 2-3) to 1.2 g (0.4 g 3 times a day), if necessary - to 2.4 g per day.

Course duration is from 4 weeks to 1.5-3 months.

For urocoproporphyria, the daily dose is 0.8 g (200 mg 4 times a day). The drug is taken daily for 1-3 months.

Side effect

Allergic reactions are possible in the form of urticaria, skin itching, skin hyperemia (discontinuation of the drug is required). Rarely, during treatment with the drug, the concentration of uric acid in the blood increases and exacerbation of gout (with long-term use).

Contraindications to the use of the drug RIBOXIN

Hypersensitivity to the drug, gout, hyperuricemia. Fructose intolerance and glucose/galactose malabsorption syndrome or sucrase/isomaltase deficiency.

With caution: renal failure, diabetes mellitus.

Use of the drug RIBOXIN during pregnancy and breastfeeding

The safety of using the drug Riboxin during pregnancy and lactation has not been established. The use of Riboxin is contraindicated during pregnancy. During treatment with Riboxin, breastfeeding should be stopped.

Use for renal impairment

With caution: renal failure.

special instructions

During treatment with Riboxin, the concentration of uric acid in the blood and urine should be monitored.

Information for patients with diabetes: 1 tablet of the drug corresponds to 0.00641 bread units.

Does not affect the ability to drive vehicles and operate mechanisms that require increased concentration.

Drug interactions

Immunosuppressants (azathioprine, antilympholine, cyclosporine, thymodepressin, etc.) when used simultaneously reduce the effectiveness of Riboxin.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

In a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date. 3 years. Do not use after the expiration date indicated on the package.

Riboxin review from a cardiologist:

I will be extremely brief: the drug is absolutely useless. Riboxin does not appear at all in the National Guidelines for Cardiology, much less in European guidelines.

Long live the placebo effect (pacifiers) and the great power of self-hypnosis. Fortunately, Riboxin is very inexpensive.

A drug that normalizes myocardial metabolism and reduces tissue hypoxia

Active substance

Release form, composition and packaging

Film-coated tablets light yellow to yellow-orange, round, biconvex, slightly rough; on a cross section, two layers are visible: the core is white or white with a slightly yellowish tint and the shell is light yellow to yellow-orange.

Excipients: potato starch 54.1 mg, methylcellulose 3.2 mg, sucrose 10 mg, stearic acid 2.7 mg.

Shell composition: opadry II yellow (polyvinyl alcohol, titanium dioxide, talc, macrogol 3350 (polyethylene glycol 3350), iron (III) oxide, aluminum varnish based on quinoline yellow) - 8 mg.

10 pieces. - contour cell packaging (5) - cardboard packs.
25 pcs. - contour cell packaging (2) - cardboard packs.

pharmachologic effect

Inosine belongs to the group of drugs that regulate metabolic processes. The drug is a precursor for the synthesis of purine nucleotides: adenosine triphosphate and guanosine triphosphate.

It has antihypoxic, metabolic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, and prevents the consequences of intraoperative renal ischemia. Takes direct part in metabolism and promotes activation of metabolism under conditions of hypoxia and in the absence of adenosine triphosphate.

Activates the metabolism of pyruvic acid to ensure the normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of some Krebs cycle enzymes. Penetrating into cells, it increases the energy level, has a positive effect on metabolic processes in the myocardium, increases the strength of heart contractions and promotes more complete relaxation of the myocardium in diastole, resulting in an increase in stroke volume of blood.

Reduces platelet aggregation, activates tissue regeneration (especially the myocardium and the mucous membrane of the gastrointestinal tract.

Pharmacokinetics

Well absorbed in the gastrointestinal tract. Metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation. A small amount is excreted by the kidneys.

Indications

Prescribed to adults in the complex treatment of coronary heart disease, after myocardial infarction, cardiac arrhythmias caused by the use of cardiac glycosides.

Prescribed for hepatitis, cirrhosis caused by alcohol or drugs, and urocoproporphyria.

Contraindications

Hypersensitivity to the drug, gout, hyperuricemia. Fructose intolerance and glucose/galactose malabsorption syndrome or sucrase/isomaltase deficiency.

Carefully:, diabetes.

Dosage

Prescribed for adults orally, before meals.

The daily dose when taken orally is 0.6-2.4 g. In the first days of treatment, the daily dose is 0.6-0.8 g (200 mg 3-4 times a day). If well tolerated, the dose is increased (on days 2-3) to 1.2 g (0.4 g 3 times a day), if necessary - to 2.4 g per day.

Course duration is from 4 weeks to 1.5-3 months.

For urocoproporphyria, the daily dose is 0.8 g (200 mg 4 times a day). The drug is taken daily for 1-3 months.

Side effects

Allergic reactions are possible in the form of urticaria, skin itching, skin hyperemia (discontinuation of the drug is required). Rarely, during treatment with the drug, the concentration of uric acid in the blood increases and exacerbation of gout (with long-term use).

Drug interactions

(azathioprine, antilympholine, cyclosporine, thymodepressin, etc.) when used simultaneously reduce the effectiveness of Riboxin.