Nurofen tablets dosage. To avoid unpleasant side effects during treatment, you should follow the rules for taking the syrup. Nurofen reduces fever

Nurofen (active ingredient - ibuprofen) is one of the most prominent representatives of non-steroidal anti-inflammatory drugs (NSAIDs), without which it is difficult to imagine the home medicine cabinet of the average person. And there are good reasons for this: drugs of this class, including, naturally, Nurofen, have pronounced anti-inflammatory, analgesic and antipyretic properties, which have been and will be in demand at all times. A key characteristic of Nurofen that helps it realize its pharmacological potential is the ability to inhibit the synthesis of prostaglandins (mediators of inflammation, pain and hyperthermic manifestations). Under the influence of Nurofen, the permeability of blood vessels is reduced, microcirculation is stimulated, and the energy-consuming inflammatory process is deprived of biochemical “feeding”. Nurofen realizes its analgesic effect through suppressing the activity of another insidious mediator that generates pain and inflammation - bradykinin. Having a diverse effect on all phases of the inflammatory reaction, incl. based on its exudative and proliferative components, Nurofen is a fast and effective analgesic that relieves swelling and makes people with problem joints forget about morning stiffness.

The antipyretic effect of Nurofen is associated with its effect on the thermoregulatory centers of the diencephalon.

Nurofen is available in the form of tablets and gel for external use. Tablets should be taken after meals 3-4 times a day, 200 mg at a time. To approximate the therapeutic effect, a twofold increase in the single dose is allowed when taking the drug 3 times a day. This is the maximum daily dose, beyond which it is not recommended. The time interval between taking the drug should not be less than 6 hours. Children 6-12 years old take no more than 1 tablet three times a day. If after 2-3 days the signs of the disease have not disappeared, you must see a doctor.

Nurofen gel is used as follows: 4-10 cm of the drug is squeezed onto the palm and carefully rubbed into the skin until completely absorbed, after which the hands are washed thoroughly. The gel should not be applied to injured areas of the skin. The frequency of this procedure is every 4 hours, but no more than 4 times a day. If after 2 weeks of using Nurofen gel it is not possible to achieve the expected effect, you should consult a doctor.

Pharmacology

NSAIDs for external use. It has a local analgesic and anti-inflammatory effect, the mechanism of which is due to the inhibition of prostaglandin synthesis.

Pharmacokinetics

Release form

Gel for external use 5%, transparent or slightly opalescent, colorless, homogeneous, with a characteristic odor of isopropyl alcohol.

Excipients: hyaetellose 1.8 g, sodium hydroxide 1 g, benzyl alcohol 1 g, isopropyl alcohol 5 g, purified water 86.2 g.

30 g - aluminum tubes (1) - cardboard packs.
50 g - aluminum tubes (1) - cardboard packs.
100 g - aluminum tubes (1) - cardboard packs.

Dosage

The drug is intended for external use.

The gel is prescribed only to adults and children over 12 years of age. A single dose is approximately 50-125 mg of ibuprofen (corresponding to approximately 4-10 cm of gel squeezed from the tube). Repeated use of the drug is possible only after 4 hours and no more than 4 times a day.

If there is no improvement after 2 weeks of use, the drug should be discontinued.

The gel should be rubbed into the skin until completely absorbed.

Overdose

Interaction

Drug interactions with Nurofen ® in gel form have not been described to date. However, even when used externally, ibuprofen can have a systemic effect, therefore, theoretically, the simultaneous use of the gel with other NSAIDs can lead to increased side effects.

Side effects

Local reactions: slight redness of the skin, burning or tingling sensation.

Other: very rarely (with hypersensitivity) - allergic reactions, bronchospasm.

Indications

• myalgia;
• back pain;
• arthritis;
• ligament damage, sprains;
• sports injuries;
• neuralgia.

Contraindications

• bronchial asthma, urticaria, rhinitis, provoked by taking acetylsalicylic acid (salicylates) or other NSAIDs;
• children under 12 years of age;
• hypersensitivity to the components of the drug or to other NSAIDs.

The drug should be used with caution in case of concomitant diseases of the liver or kidneys, gastrointestinal tract, as well as in case of urticaria, rhinitis or polyps of the nasal mucosa, during pregnancy and lactation.

Features of application

Use during pregnancy and breastfeeding

Use for liver dysfunction

Use for renal impairment

Use in children

special instructions

After using the drug, wash your hands thoroughly.

Avoid getting the gel in your eyes and lips. Do not apply the gel to damaged areas of the skin, as well as to the area around the eyes and lips.

If the gel is accidentally ingested, gastrointestinal disorders may develop; in this situation, you should rinse your mouth and consult a doctor.

Compound

One film-coated tablet contains the active substance:

200 mg ibuprofen;

excipients: croscarmellose sodium 30 mg, sodium lauryl sulfate 0.5 mg, sodium citrate dihydrate 43.5 mg, stearic acid 2.0 mg, colloidal silicon dioxide

Shell composition: carmellose sodium 0.7 mg, talc 33.0 mg, acacia gum 0.6 mg, sucrose 116.1 mg, titanium dioxide 1.4 mg, macrogol 6000 0.2 mg, black ink [Opacode S-1 - 277001JND*.

*(The inscription Nurofen is applied in black ink [Opacode S-1-277001JND - (shellac, black iron oxide dye (E172), propylene glycol, isopropanol**, butanol**, ethanol**, purified water**.

** Solvents evaporated after the printing process)

Description

Round, biconvex, white or off-white film-coated tablets with black Nurofen imprint on one side of the tablet.

pharmachologic effect

The drug belongs to non-steroidal anti-inflammatory drugs (NSAIDs). Nurofen® has analgesic, antipyretic and anti-inflammatory effects. Indiscriminately blocks COX1 and COX2. The mechanism of action of ibuprofen is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction.

The decrease in temperature during fever begins 30 minutes after administration, its maximum effect appears after 3 hours.

The leading analgesic mechanism is a decrease in the production of prostaglandins of classes E, F and I, biogenic amines, which leads to the prevention of the development of hyperalgesia at the level of changes in the sensitivity of nociceptors. The analgesic effect is most pronounced for inflammatory pain. The pain-relieving effect is felt within 15 minutes after taking ibuprofen.

The anti-inflammatory effect is due to inhibition of cyclooxygenase (COX) activity. As a result, the synthesis of prostaglandins in inflammatory foci. This leads to a decrease in the secretion of inflammatory mediators and a decrease in the activity of the exudative and proliferative phases of the inflammatory process.

Pharmacokinetics

Absorption is high, binding to plasma proteins (mainly albumin) is more than 90%. The high degree of protein binding results in a relatively low volume of distribution (0.1 l/kg). Although ibuprofen binds actively to albumin, this does not affect drug interactions.

Time to reach maximum plasma concentration T max - 1-2 hours. Half-life - 2 hours. In elderly people (over 65 years of age), the half-life of the drug increases and overall clearance decreases. According to some data, infants aged 6-18 months have a higher Tmax (3 hours). It is believed that in children the half-life of ibuprofen does not differ significantly from the value established for adults.

Eating slows down the absorption of ibuprofen, but does not reduce its bioavailability. When taken with food, Tmax increases by 30-60 minutes compared to taking on an empty stomach and is 1.5-3 hours.

Ibuprofen slowly penetrates into the joint cavity, lingers in the synovial tissue, creating higher concentrations in it than in plasma; the maximum concentration is observed 5-6 hours after administration. Lower concentrations of ibuprofen are found in cerebrospinal fluid compared to plasma. After absorption, about 60% of the pharmacologically inactive R form is slowly transformed into the active S form in the gastrointestinal tract and liver. Metabolized in the liver to form 4 metabolites. It is excreted by the kidneys (70-90% of the administered dose in the form of ibuprofen and its metabolites; unchanged, no more than 1%) and, to a lesser extent, with bile (less than 2%). Excretion of metabolites in urine is usually complete within 24 hours of the last dose. The complete urinary excretion of ibuprofen and its metabolites is linearly dependent on dosage. After 2 months of age, the kidneys are well developed enough to cope with the elimination of ibuprofen through glomerular filtration. The study, which included 49 children aged 3 months to 12 years, showed no age-related differences in the rate of absorption and elimination of ibuprofen.

Indications for use

Nurofen is used for headaches and toothaches, migraines, painful menstruation, neuralgia, back pain, muscle and rheumatic pain; as well as in case of fever due to influenza and colds.

Contraindications

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, including peptic ulcer of the stomach and duodenum in the acute phase and/or recurrent form, ulcerative colitis, peptic ulcer, Crohn's disease;

Gastrointestinal bleeding or perforation associated with NSAIDs;

Severe heart failure;

Severe arterial hypertension;

Hypersensitivity to ibuprofen or to the components of the drug;

Complete or incomplete acetylsalicylic acid intolerance syndrome (rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma); - diseases of the optic nerve; impaired color vision, amblyopia, scotoma;

Glucose-6-phosphate dehydrogenase deficiency, hemophilia and other bleeding disorders, hemorrhagic diathesis, hypocoagulation conditions;

Pregnancy III trimester, period of breastfeeding;

Severe liver dysfunction;

Severe renal failure (creatinine clearance less than 30 ml/min);

Hearing loss, pathology of the vestibular apparatus;

Gastrointestinal bleeding in acute and recurrent form;

Intracranial hemorrhages;

Hemophilia and other bleeding disorders, hemorrhagic diathesis;

Children under 6 years of age;

With caution: elderly age, coronary heart disease, cerebrovascular diseases, dyslipidemia, diabetes mellitus, diseases of peripheral arteries, smoking, frequent alcohol consumption, long-term use of NSAIDs, severe somatic diseases, concomitant use of oral corticosteroids (including prednisolone), anticoagulants (including warfarin, clopidogrel, acetylsalicylic acid), taking selective serotonin reuptake inhibitors, diseases when taking the drug in patients with a history of gastric and duodenal ulcers, gastritis, enteritis, colitis, with anamnestic information about bleeding from the gastrointestinal tract; in the presence of concomitant liver and/or kidney diseases; for liver cirrhosis with portal hypertension, nephrotic syndrome, chronic heart failure; arterial hypertension; for blood diseases of unknown etiology (leukopenia and anemia); for bronchial asthma, for hyperbilirubinemia; pregnancy (I, II trimesters); age under 12 years.

Pregnancy and lactation

The use of the drug during pregnancy is possible only under the supervision of a doctor. Use of the drug during the 1st and 2nd trimesters is undesirable, but possible with caution. If Nurofen is used by a woman planning a pregnancy, or by a woman in the first and second trimesters of pregnancy, the lowest effective dose and shortest treatment period should be selected.

Use during the third trimester is contraindicated.

The use of the drug during lactation is not recommended. Ibuprofen has been found in very low concentrations in breast milk in a number of studies and is unlikely to affect infants.

Directions for use and doses

The drug is intended for short-term use.

NUROFEN® is prescribed to adults and children over 12 years of age orally, after meals, in tablets of 200 mg 3-4 times a day. The tablets should be taken with water.

To achieve a rapid therapeutic effect in adults, the dose can be increased to 400 mg (2 tablets) 3 times a day.

The minimum effective dose should be used for the shortest time necessary to relieve symptoms.

Do not take more than 6 tablets in 24 hours. The maximum daily dose is 1200 mg. If symptoms persist after taking the drug for 2-3 days, you should stop treatment and consult a doctor.

It is recommended to exercise extreme caution when prescribing the drug to patients with reduced renal function. If this function is significantly reduced, periodic monitoring of creatinine clearance or serum creatinine concentration is recommended.

The use of the drug in patients with chronic liver diseases and in the elderly should be carried out under the supervision of a physician.

If you miss the next dose of the drug, it is recommended to take the dose in accordance with the prescribed dosage regimen, without doubling the amount of the drug.

In exceptional cases (in the absence of children's forms of ibuprofen), as prescribed and under the supervision of a doctor, the drug can be prescribed to children aged 6 to 12 years: 1 tablet no more than 3-4 times a day; the drug can only be used if the child’s body weight is more than 20 kg. The interval between taking tablets is at least 6 hours.

For children aged 6-9 years (average child weight 20-29 kg), the maximum dose is no more than 600 mg of ibuprofen per day (3 tablets per day).

For children aged 10-12 years (average child weight 30-40 kg), the maximum dose is no more than 800 mg of ibuprofen per day (4 tablets per day).

Side effect

When using the drug NUROFEN® for 2-3 days, practically no side effects are observed. In case of long-term use, the following side effects may occur:

From the gastrointestinal tract: nausea, vomiting, heartburn, anorexia, pain and discomfort in the epigastrium, diarrhea, flatulence, possible erosive and ulcerative lesions of the gastrointestinal tract (in some cases complicated by perforation and bleeding), abdominal pain, irritation , dryness of the oral mucosa or pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis, pancreatitis, constipation, hepatitis.

From the nervous system: headache, dizziness, insomnia, agitation, drowsiness, depression, confusion, hallucinations, rarely - aseptic meningitis (more often in patients with autoimmune diseases).

From the cardiovascular system: heart failure, increased blood pressure (BP), tachycardia.

From the urinary system: nephrotic syndrome (edema), acute renal failure, allergic nephritis, polyuria, cystitis.

From the hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.

From the senses: hearing loss, ringing or noise in the ears, reversible toxic optic neuritis, blurred vision or diplopia, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic origin), scotoma.

Allergic reactions: skin rash, itching, urticaria, Quincke's edema, anaphylactoid reactions, anaphylactic shock, fever, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis.

From the respiratory system: bronchospasm, shortness of breath.

Other: increased sweating.

With long-term use in large doses - ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (impaired color vision, scotoma, amblyopia). If side effects occur, the doctor should stop taking the drug.

Overdose

Symptoms: abdominal pain, nausea, vomiting, lethargy, headache, tinnitus, metabolic acidosis, coma, acute renal and liver failure, gastrointestinal bleeding, decreased blood pressure (BP), bradycardia, tachycardia, atrial fibrillation, arrest breathing, increased prothrombin time, convulsions are rarely possible.

Treatment: within the first hour after taking the drug, gastric lavage and intake of activated charcoal

In case of frequent or prolonged seizures, it is necessary to use anticonvulsants (diazepam or lorazepam intravenously).

Interaction with other drugs

Concomitant use of NUROFEN tablets with acetylsalicylic acid (aspirin) is not recommended unless taking low-dose aspirin (not exceeding 75 mg per day) is recommended by your doctor, as it increases the risk of adverse side effects. When taken concomitantly, ibuprofen may inhibit the effect of low-dose aspirin on platelet aggregation.

You should also avoid taking two or more NSAIDs at the same time, including selective cyclooxygenase-2 inhibitors, as this may increase the risk of side effects.

When prescribed with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding simultaneously increases. Cefamandole, cefaperazone, cefotetan, valproic acid, plicamycin, increase the incidence of hypoprothrombinemia.

Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by an increased risk of nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects.

NSAIDs should not be used for 8 to 12 days after taking mifepristone because NSAIDs may reduce the effect of mifepristone.

Concomitant use of NSAIDs and tacrolimus may increase the risk of nephrotoxicity.

When NSAIDs and zidovudine are taken concomitantly, the risk of hematological toxicity increases.

Patients taking NSAIDs and quinolones have an increased risk of seizures. Drugs that block tubular secretion reduce excretion and increase plasma concentrations of ibuprofen.

Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions. Inhibitors of microsomal oxidation - reduce the risk of hepatotoxicity.

Reduces the hypotensive activity of vasodilators, natriuretic in furosemide and hydrochlorothiazide.

Reduces the effectiveness of uricosuric drugs, enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics.

Increases the side effects of mineralocorticosteroids, glucocorticosteroids, estrogens, ethanol.

Enhances the effect of oral hypoglycemic drugs, sulfonylurea derivatives and insulin. Antacids and cholestyramine reduce absorption.

Increases the blood concentration of digoxin, lithium preparations, methotrexate. Caffeine enhances the analgesic effect.

Precautionary measures

Nurofen is prescribed with caution to patients with heart failure, arterial hypertension, bleeding disorders, and impaired renal and/or liver function. Caution should be exercised when using the drug in patients with bronchial asthma and other obstructive pulmonary diseases due to the risk of bronchospasm. Patients with diseases of the gastrointestinal tract (ulcerative colitis, Crohn's disease) should be prescribed NSAIDs with caution due to a possible exacerbation of these diseases.

The drug is prescribed with caution to elderly patients, as they are more likely to experience adverse side reactions to NSAIDs, mainly gastrointestinal bleeding and perforation, which can lead to a sharp deterioration of the condition. Patients with a history of gastrointestinal toxicity, especially the elderly, should report any unusual abdominal symptom (especially gastrointestinal bleeding), especially if the symptom is observed during the initial phase of taking the drug.

If patients develop gastrointestinal bleeding while taking the drug, the drug should be stopped immediately.

The simultaneous use of Nurofen and other NSAIDs, including selective cyclooxygenase-2 inhibitors, should be avoided.

Systemic lupus erythematosus, as well as mixed connective tissue diseases, increase the risk of aseptic meningitis.

There is some evidence that drugs that inhibit cyclogenase/prostaglandin synthesis may impair fertility in women by affecting ovulation. This phenomenon is reversible when the drug is discontinued.

The drug should not be prescribed to patients with fructose intolerance, glucose-galactose malabsorption syndrome or sucrase-isomaltase deficiency.

Two Nurofen tablets contain 25.3 mg sodium, which should be taken into account in patients on a sodium-controlled diet.

During long-term treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary.

When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a complete blood count (hemoglobin determination), and a stool test for occult blood. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

Patients should refrain from all activities related to driving vehicles and working with moving mechanisms, as well as other potentially hazardous activities associated with concentration and increased speed of psychomotor reactions.

During the treatment period you should refrain from drinking alcoholic beverages.

When used in children aged 6 to 12 years, it should be borne in mind that the tablets cannot be divided, and therefore can only be used in those children whose single dose is at least 1 tablet.

Manufacturer: Reckitt Benckiser healthcare international Ltd. Great Britain

PBX code: M01AE01

Farm group:

Release form: Solid dosage forms. Pills.

General characteristics. Compound:

Pharmacological properties:

Indications for use:

Important! Get to know the treatment

Directions for use and dosage:

Features of application:

Side effects:

Interaction with other drugs:

Contraindications:

Overdose:

Storage conditions:

Store out of the reach of children at a temperature not exceeding 25°C. Shelf life: 3 years. Do not consume after the expiration date indicated on its packaging.

Vacation conditions:

Over the counter

Package:

6 or 12 tablets per blister (PVC/PVDC/aluminium).
One blister (6 or 12 tablets each), two blisters (6 or 12 tablets each), 3 blisters (12 tablets each) or 8 blisters (12 tablets each) are placed in a cardboard box or plastic container along with instructions for use.

Treatment of such a serious disease as prostatitis requires a competent selection of drugs. The role of antibiotics in the treatment of this disease is great, but in addition to them, auxiliary therapy is also needed. After all, very often prostatitis is accompanied by pain and inflammation.

To alleviate the patient’s condition, the doctor prescribes non-steroidal anti-inflammatory drugs. And most often we are talking about Nurofen tablets.

Indications for use of Nurofen

This is a multifunctional remedy, thanks to which you can not only quickly cope with pain of various types, but also remove inflammation and relieve fever. It helps during migraine attacks, pain in the spine due to osteochondrosis, intercostal neuralgia, painful menstruation, etc.

Types of Nurofen tablets and their purpose

When choosing an anesthetic, you need to take into account the nature of the pain:

• For mild pain, Nurofen 200 mg tablets are suitable. They help reduce and eliminate pain for up to 8 hours, relieve headaches, migraines, lower back pain, and also reduce inflammation.
• For severe pain, you should take Nurofen Forte 400 mg tablet. One pill contains more active substance than a regular Nurofen tablet. Therefore, the effect of the pill begins very quickly. The drug helps cope with intense pain.
• For prolonged pain, the Nurofen Long tablet will help. It is more effective due to the fact that it contains two analgesics – ibuprofen and paracetamol. The drug "Nurofen Long" helps when conventional analgesics do not bring the desired result.

Tablets (capsules) “Nurofen Express”

They contain 200 mg of active. They do not contain sucrose, lactose, or gluten. They differ from other drugs in the Nurofen line in that they begin to work within half an hour. The active substance of the drug is quickly absorbed into the blood and acts directly on the source of pain. Nurofen Express tablets help with mild to moderate pain.

Nurofen Long tablets

Effervescent tablets "Nurofen"

New soluble tablets have recently appeared in the Nurofen product line.

Their advantage over conventional hard pills is that:

• They are more easily and quickly absorbed by the body;
• They do not harm the digestive system;
• They do not cause side effects;
• They are safe and easy to take, even for an elderly person who has dental problems or finds it difficult to swallow a hard pill.

Nurofen effervescent tablets contain 200 mg of ibuprofen. You can take them no more than 4 times a day.

Nurofen Plus tablets

Unlike regular Nurofen tablets, they are coated. But this is not the main difference. The difference from conventional anti-inflammatory and pain-relieving pills is that, in addition to ibuprofen (200 mg), Nurofen Plus also contains codeine (10 mg), a narcotic substance that enhances the pain-relieving effect of ibuprofen. Therefore, this remedy has a powerful analgesic effect.

Instructions for use

Restrictions

Nurofen tablets, like any other medicine, should be prescribed by a specialist. Self-medication with this drug is unacceptable in the following cases:

• If the patient is taking other medications, which include ibuprofen, aspirin, ketoprofen and other anti-inflammatory substances. Concomitant use of Ibuprofen with such drugs may cause side effects.
• If a person regularly takes medications (diuretics, antihypertensive drugs, anticoagulants, thrombolytic drugs, etc.), then Nurofen may reduce the effect of some medications and also cause side effects.
• If the patient suffers from asthma. People suffering from asthma attacks and taking the drug "Nurofen" may experience hypersensitivity (allergic reaction) to the active ingredient of the tablets - ibuprofen, up to bronchospasm.
• If a person has crossed the age of 60. In elderly people, even a single dose of the drug without a doctor’s prescription can cause deterioration in health.

Nurofen's analogs

You can replace this drug with another drug of similar effect.

The main thing is that the tablets belong to the category of non-steroidal anti-inflammatory drugs.

The most common substitutes for Nurofen tablets are the following medications: Aspirin, Ibuprofen, Nimesil, Indomethacin, etc. But each of these drugs has its own limitations and features of use. Therefore, you cannot decide on your own to change the medication. You need to discuss this point with your doctor.

Cost of Nurofen tablets

The price of the drug in tablet form can vary from 100 to 400 rubles per package, depending on:

1. Type of drug;
2. Concentration of the active substance;
3. Number of tablets per package;
4. Manufacturer;
5. Pharmacy markups.

The approximate price of tablets is shown in the table below:

Nurofen tablets: user reviews

Gennady, 42 years old:

“I took Nurofen tablets during complex treatment of prostatitis. Along with antibiotics and drugs that make urination easier, I took this remedy. The temperature went away on the first day of treatment. And I managed to remove the inflammatory swelling after 3 days. The product works quickly, I had no side effects. I took the pills strictly according to the instructions: 3 tablets a day.”

Dmitry, 35 years old:

“Nurofen helped me during the treatment of prostatitis. Thanks to him, I forgot what it was like to have a painful urge to urinate, pain in the urethra and rectum. In the phase of exacerbation of prostatitis, I took Nurofen Express tablets, then switched to regular Nurofen. Nurofen is ideal as an aid to alleviate prostatitis. And the effect of the medicine is quick, and the price is not bad.”

FAQ

Is it possible to take Nurofen tablets together with other analgesic or anti-inflammatory drugs?

No you can not. Concomitant use of drugs with similar effects significantly increases the likelihood of side effects. If the patient is not sure whether a particular drug belongs to the group of painkillers or anti-inflammatory drugs, then he should consult a doctor.

Is it possible to take Nurofen tablets from different lines at the same time?

No, you can’t, because the active ingredient in tablets of all types of the Nurofen line is ibuprofen. If a person takes Nurofen Long and Nurofen at the same time, the daily dose of ibuprofen will be increased. Do not exceed the daily dosage of 1200 mg of ibuprofen. If Nurofen in its various variations does not help the patient, then you need to consult a doctor and not experiment with your health.

Is it possible to take Nurofen and Paracetamol tablets at the same time?

Yes, you can. The fact is that the drug “Paracetamol” does not belong to the group of non-steroidal anti-inflammatory drugs. It is an antipyretic and analgesic, so it can be taken simultaneously with Nurofen. Just follow the instructions for use of both products and do not exceed the dosage recommended in the instructions.

Is it possible to take Nurofen tablets with alcohol?

No. Alcoholic drinks can increase side effects and also reduce the effect of ibuprofen, the active substance of Nurofen tablets.

The drug "Nurofen" is a common remedy for relieving the inflammatory process, pain during prostatitis, as well as other diseases: rheumatism, arthritis, headaches and toothaches, ENT diseases, infectious and inflammatory processes. Thanks to the diversity of the Nurofen product line, each patient can choose the ideal medicine for himself, depending on the severity of the disease, the nature and intensity of the pain syndrome.

Thank you

Nurofen is a drug from the group of non-steroidal anti-inflammatory drugs(NSAID), which has analgesic, anti-inflammatory and antipyretic effects in various pathological conditions and diseases. Therefore, Nurofen is used as a symptomatic remedy in the complex treatment of various diseases accompanied by pain, inflammation in the tissues and increased body temperature. Thus, Nurofen is used to eliminate painful symptoms (pain, fever and inflammation) for influenza, acute respiratory infections, acute respiratory viral infections, headaches, dental, muscle, joint and menstrual pain, severe sore throat, neuralgia, migraines, as well as damage to ligaments and muscles and sports injuries.

Types, names and forms of release of Nurofen

• Nurofen;
• Nurofen Active;
• Nurofen for children (children);
• Nurofen Period;
• Nurofen Plus;
• Nurofen Plus N;
• Nurofen Ultracap;
• Nurofen Ultracap Forte;
• Nurofen Forte;
• Nurofen Express;
• Nurofen Express Neo.

Varieties of Nurofen are available in the following dosage forms:

• Nurofen - tablets for oral administration, effervescent tablets for solution and gel for external application;
• Nurofen Active – lozenges;
• Nurofen for children – oral suspension and rectal suppositories;
• Nurofen Period - extended-release tablets;
• Nurofen Plus and Nurofen Plus N – film-coated tablets;
• Nurofen Ultracap and Ultracap Forte – capsules for oral administration;
• Nurofen Forte – tablets;
• Nurofen Express – capsules and tablets;
• Nurofen Express Neo are sugar-coated tablets.

Nurofen - composition

• Tablets for oral administration and effervescent tablets for the preparation of Nurofen solution;
• Nurofen Active tablets;
• Tablets Nurofen Plus and Plus N;
• Nurofen Ultracap capsules;
• Tablets Nurofen Express and Express Neo.

Other varieties and formulations of Nurofen contain ibuprofen in the following dosages:

• Nurofen gel for external application – 5% (5 g of ibuprofen per 100 g of finished product);
• Nurofen for children - suppositories 60 mg per suppository and 100 mg per dose of suspension (100 mg per 5 ml);
• Nurofen Period – 300 mg of ibuprofen per extended-release tablet;
• Nurofen Forte – 400 mg per tablet;
• Nurofen Ultracap Forte – 400 mg per capsule.

Therapeutic effect

All these effects of Nurofen are provided by its ability to block the enzyme cyclooxygenase-2 , which catalyzes the formation of special substances - prostaglandins . Prostaglandins, in turn, are substances that cause pain, inflammation in tissues, as well as an increase in overall body temperature or a local sensation of heat in the area of ​​injury. That is, Nurofen simply stops the synthesis of biologically active substances that cause pain, inflammation and fever, thereby eliminating these symptoms.

Nurofen - indications for use

So, all forms of Nurofen for oral administration indicated for use for the relief of pain, fever and inflammation in the presence of the following diseases or conditions:

• Arthritis of various types, accompanied by pain and inflammation of the joints (rheumatoid arthritis, psoriatic arthritis, osteochondrosis, arthritis with systemic lupus erythematosus);
• Neuralgic amyotrophy;
• Ankylosing spondylitis (Bechterew's disease);
• Pain syndrome of any localization, regardless of the causative factor (toothache, headache, menstrual pain, pain in muscles, bones and joints, radiculitis, migraine, bursitis, tendonitis, tendovaginitis, etc.);
• Pain after surgery or injury;
• Pain due to malignant tumors;
• Painful menstruation;
• Pain due to the inflammatory process in the pelvis (for example, adnexitis, endometritis, etc.);
• Pain during childbirth;
• As a drug to suppress the contractile activity of the uterus when there is a threat of premature birth;
• Temperatures due to infectious diseases or colds.

It should be remembered that Nurofen is indicated only for symptomatic therapy to reduce pain and inflammation, but it does not affect the cure or improvement of the disease. Therefore, in addition to Nurofen, specialized medications are needed for treatment.

Gel Nurofen indicated for topical use for the following conditions or diseases:

• Muscle pain;
• Arthritis;
• Ligament damage;
• Injuries while playing sports;
• Neuralgia.

Nurofen for children - indications for use

• Flu;
• Childhood infections;
• Reactions to vaccination.

• Headache;
• Toothache;
• Migraine;
• Neuralgia;
• Pain after injuries to muscles, tendons, joints, ligaments and bones.

Instructions for use

Nurofen tablets and capsules - instructions for use

If pain, inflammation or fever does not go away within 2 to 3 days from starting Nurofen, you should stop taking the drug and consult a doctor immediately. It is also necessary to stop taking Nurofen and consult a doctor if side effects occur.

If it is necessary to take medications containing steroid hormones, Nurofen should be discontinued two days before. In addition, during the entire period of taking Nurofen, you must refrain from drinking alcohol.

During the entire period of Nurofen therapy, it is necessary to regularly, at least once every 1-2 weeks, take a general and biochemical blood test to determine the activity of liver enzymes (AST, ALT), as well as the concentration of urea and creatinine. If deviations from the norm occur, you must stop taking the drug and consult a doctor. Also, during the entire course of therapy with Nurofen, it is necessary to monitor the condition of the stomach, since the drug can provoke gastropathy. If gastropathy (unpleasant stomach symptoms) is suspected, it is necessary to undergo an examination, based on the results of which the doctor will decide whether to continue or suspend therapy.

The dosage and duration of taking Nurofen depend on the disease for which the drug is taken to eliminate the symptoms.

To relieve dental, menstrual, muscle, traumatic and other intermittent pain, adults and children over 12 years of age should take Nurofen tablets or capsules 200 mg 3 to 4 times a day. In order to obtain the fastest effect, Nurofen can be taken 400 mg 3 times a day. Extended-release tablets (Nurofen Period) should be taken 300 mg twice a day. Children from 6 to 12 years old can be given Nurofen 200 mg no more than 4 times a day. That is, the maximum permissible dosage for children 6–12 years old is 800 mg. In addition, it must be remembered that “adult” varieties of Nurofen can only be given to children whose body weight is more than 20 kg. Children weighing less than 20 kg should only be given children's Nurofen.

The interval between taking regular tablets and capsules should be at least 6 hours, and extended-release tablets should be at least 12 hours. The maximum daily dosage of Nurofen in tablets and capsules is no more than 1200 mg (1.2 g).

For severe chronic diseases accompanied by pain and inflammation, Nurofen must be taken long-term in the following dosages:

• Osteoarthritis, arthritis, ankylosing spondylitis - take 400 - 600 mg 3 - 4 times a day.
• Rheumatoid arthritis - take 800 mg 3 times a day.
• Juvenile rheumatoid arthritis - the dosage is calculated individually, based on the ratio of 30 - 40 mg per 1 kg of body weight. The total calculated dosage is divided into 3 to 4 doses per day.
• Soft tissue injuries (muscles, ligaments, tendons) – take 400–600 mg 4 times a day every 6 hours.
• For painful menstruation, take 400 mg 3-4 times a day.

Nurofen for children (syrup and suppositories) – instructions for use

For children over 12 years of age, Nurofen is given 150–300 mg (7.5–15 ml of solution) 3 times a day to reduce fever and relieve pain, and after relief of symptoms and improvement of condition, the dosage is reduced to 100 mg (5 ml) according to 3 times a day. The maximum permissible daily dosage of Nurofen for children over 12 years of age is 1000 mg (1 kg).

For juvenile rheumatoid arthritis, the dosage of the suspension is calculated individually by body weight, based on the ratio of 30 - 40 mg per 1 kg of weight. The calculated dosage is divided into three doses per day.

In order to reduce fever and symptomatic treatment of childhood infections, colds, acute respiratory viral infections and other similar conditions, Nurofen is given to a child in the following dosages depending on age:

• Children aged 3 – 6 months – 50 mg (2.5 ml suspension) three times a day;
• Children 6 – 12 months – 50 mg (2.5 mg) 3 – 4 times a day;
• Children 1 – 3 years old – 100 mg (5 ml) 3 times a day;
• Children 4 – 6 years old – 150 mg (7.5 ml) 3 times a day;
• Children 7 – 9 years old – 200 mg (10 ml) 3 times a day;
• Children 10 – 12 years old – 300 mg (15 ml) 3 times a day.

If the temperature rises after vaccination, you can give the child 2.5 ml of the suspension once. After 6 hours, if necessary, you can give the child another 2.5 ml of suspension. More than 5 ml of Nurofen syrup per day should not be given to a child to reduce the temperature after vaccination.

Rectal suppositories in children are used for the same purpose as syrup. Suppositories can be chosen if the baby is unable to swallow the solution for some reason, for example, the child is vomiting, and therefore taking the syrup is impossible. Also, candles are preferable if you need to get a quick effect.

The suppositories are inserted into the child's anus by gently pushing them with the index finger of the hand. The suppository must be pushed to the inner border of the sphincter, for which it should be inserted with a finger to the middle of the second phalanx.

Children aged 3–9 months are given 1 suppository 3 times a day to reduce fever and relieve pain. And children aged 9 months - 2 years are administered one suppository 4 times a day, every 6 hours.

In order to reduce the temperature that has risen after vaccination, children are given 1 suppository. For children over 1 year old, if necessary, you can introduce another suppository, but only 6 hours after using the first one.

The duration of use of suppositories and suspension of children's Nurofen to reduce temperature is a maximum of 3 days, and for pain relief - 5 days.

Nurofen suppositories and suspension can be used in children with diabetes because they do not contain sugar. Children's forms of Nurofen should be used with caution if the child has a past or present stomach ulcer, gastritis, ulcerative colitis, bleeding from the digestive tract, urticaria, bronchial asthma, eczema, as well as liver and kidney pathologies. You should also be careful when combining Nurofen with other painkillers, diuretics, antihypertensive drugs, as well as anticoagulants (drugs that reduce clotting), methotrexate and lithium compounds.

If a child develops side effects of Nurofen, you must stop using the drug and consult a doctor.

Nurofen gel - instructions for use

For one-time use, squeeze out 4–10 cm of gel from the tube and gently distribute it over the area of ​​the skin with light massage movements, rubbing until completely absorbed into the skin. The gel can be used a maximum of 4 times a day, keeping an interval of at least 4 hours between rubbing into the skin. If the condition does not improve within two weeks after starting to use the gel, then its use should be stopped and consult a doctor.

After applying the gel to the skin, wash your hands with soap and wipe dry. When using the gel, it is necessary to avoid getting it into the eyes, lips and mouth. If the gel accidentally gets into your eyes, lips or mouth, you should rinse them with cold running water.

Nurofen in gel form should not be applied to areas of the skin with wounds or other damage, as well as to the areas around the eyes and lips.

Impact on the ability to operate machinery

Overdose

So, the symptoms of an overdose of Nurofen are the following:

• Nausea;
• Vomit;
• Lethargy;
• Depression;
• Reduced blood pressure;
• Tachycardia;
• Atrial fibrillation;
• Stopping breathing;
• Acute renal failure.

Interaction with other drugs

Firstly, it is not recommended to use Nurofen in combination with other drugs from the NSAID group (Aspirin, Paracetamol, Ketorol, Nimesulide, etc.).

When Nurofen is used simultaneously with drugs to reduce blood clotting (anticoagulants) and dissolve blood clots (thrombolytics), their effects are enhanced, which can cause bleeding.

Simultaneous use of Nurofen in combination with antidepressants from the group of serotonin reuptake inhibitors (Citalopram, Fluoxetine, Paroxetine, Sertraline, etc.) increases the risk of bleeding from the digestive tract.

Combined use with Cefamandole, Cefoperazone, Cefotetan, Valproic acid and Plicamycin disrupts normal blood clotting.

Nurofen increases the severity of side effects of glucocorticosteroids, mineralocorticoids, estrogens and ethyl alcohol.

Nurofen during pregnancy

In the last months of pregnancy, Nurofen should not be used, as this can provoke fetal pathology - non-closure of the duct between the ventricles of the heart, as well as post-maturity and complications during childbirth. A blocked duct in the fetus can be treated, but it is better to prevent it than to eliminate it later. And postmaturity and complications during childbirth can provoke various damage to the fetus, which is also best avoided. Therefore, it is not recommended to use Nurofen during the last month of pregnancy.

During pregnancy, to relieve pain, reduce inflammation and normalize body temperature, Nurofen is used in normal adult dosages, that is, 200 mg 3 to 4 times a day. It is not recommended to increase the dosage of Nurofen to 400 mg 4 times a day. Pregnant women should take Nurofen 200 mg once if necessary to relieve pain. If improvement does not occur within an hour, then you can take another 200 mg of Nurofen. The next dose can be taken no earlier than 6 hours later. If Nurofen is prescribed by a gynecologist to prevent premature birth, then the drug should be taken according to the prescribed regimen.

During pregnancy, Nurofen should not be used by women who suffer from bronchial asthma, heart failure, bleeding disorders, liver, kidney and hearing diseases, as well as high blood pressure.

Nurofen for pain

It is recommended to take Nurofen for pain at 200–400 mg every 6 hours, but no more than 4 times a day. The drugs Nurofen Plus and Nurofen Plus N have the most powerful analgesic effect, since in addition to ibuprofen they contain codeine, which enhances the analgesic effect of the former.

Does Nurofen reduce fever?

Side effects

Tablets and capsules (for adults)

• Nausea;
• Vomit;
• Feeling of discomfort in the stomach area;
• Diarrhea;
• Erosive and ulcerative lesions of the mucous membrane of the digestive tract;
• Abdominal pain;
• Irritation and dryness of the oral mucosa;
• Ulceration of gums;
• Aphthous stomatitis;

• Headache;
• Confusion;
• Dizziness;
• Insomnia;
• Excitation;
• Drowsiness;
• Depression;
• Aseptic meningitis (in people suffering from autoimmune diseases).

• Reversible optic neuritis;
• Blurred vision;
• Diplopia (double objects in front of the eyes);
• Dryness and irritation of the mucous membrane of the eye;