An excellent antidepressant. Modern antidepressants: names. Antidepressants without a prescription: names

Update: October 2018

Depression can be described as general emotional exhaustion. As a rule, this is due to the inability to resolve an important, from the point of view this person, task. When a person is suppressed by external circumstances and fails to adequately realize his desires and ambitions, the body may well respond with situational depression.

Another common type of depressive disorder is somatization depression. At the same time, mental discomfort results in diseases internal organs (peptic ulcer, hormonal disorders, cardiovascular problems).

Depression is also known due to fluctuations in the level of sex hormones (during menopause or after childbirth), as a result of prolonged stress, chronic or incurable disease, injury or disability.

In general, depression is irritability multiplied by weakness against the background low level own pleasure hormones (enkephalins and enedorphins) in the brain, which leads to dissatisfaction with oneself and the surrounding reality in the absence of the strength to change anything radically.

Possible workarounds include support from the environment, a specialist (psychiatrist or psychologist) and/or medication. If circumstances are favorable, this will help you choose new priorities in life and get rid of the very reason that led to your painful state of mind.

Medicines that treat depression are called antidepressants. Their use has made a real splash in psychiatry and has significantly improved the prognosis of patients with depression, and also significantly reduced the number of suicides due to depressive disorders.

Antidepressants without a prescription

Today, only the lazy do not treat depression. Psychologists with pedagogical education, coaches of all stripes, traditional healers and even hereditary witches. This whole heterogeneous company nevertheless reads something on the problem and understands that it is unlikely that it will be possible to cure real clinically significant depression simply by talking and laying on of hands.

And many who feel that they have begun to fall into a pit of depression, but are afraid to contact a psychiatrist, do not mind taking medications that could simply be bought without a prescription at the pharmacy. This is because the system psychiatric care In our country, everything is still more reminiscent of a light mixture of the army and the bazaar, because either immediately “registered” or for money!

We will immediately disappoint the audience with the message that today’s antidepressants are prescription drugs. If some commercial pharmacy, in violation of the rules, sells something without a prescription, then antidepressants will not become over-the-counter. They have a lot of serious side effects, so the advisability of taking them and individual selection of dosages should be carried out only by the attending physician.

Unfortunately, just take some antidepressant and hope for quick release from depression is a hopeless matter. After all, depression and depression are different. On the same dosages of the same anti-depression medication, one patient achieves full clinical recovery, while another just begins to develop suicidal thoughts.

What are the best antidepressants to take?

Any sane person understands that it is better to be treated with those drugs prescribed by a specialist who understands this, is guided by treatment standards, information about the drug and his own clinical experience application of the product.

Turning your own precious body into a testing ground for antidepressants is, at a minimum, imprudent. If such a fixed idea has come to you, then it is better to find some Institute of Psychiatry, where programs for clinical trials of medications are regularly held (at least you will receive competent advice and free treatment).

In general, antidepressants are medications that elevate mood, improve overall mental well-being, and also cause emotional uplift without falling into euphoria or ecstasy.

Names of antidepressants

Antidepressants can be divided depending on their effect on inhibition processes. There are drugs with a calming, stimulating and balanced effect.

• Sedatives: Amitriptyline, Pipofezin (Azafen), Mianserin (Lerivon), Doxepin.
• Stimulants: Metralindole (Inkazan), Imipramine (Melipramine), Nortriptyline, Bupropion (Wellbutrin), Moclobemide (Aurorix), Fluoxetine (Prozac, Prodel, Profluzac, Fluval).
• Balanced drugs: clomipramine (Anafranil), Maprotiline (Ludiomil), Tianeptine (Coaxil), Pyrazidol.

All of them are divided into seven large groups, each of which has its own indications and preferences for certain manifestations of depression.

Tricyclic antidepressants

These are first generation drugs. They interfere with the reuptake of norepinephrine and serotonin at the nerve synapse. Due to this, these mediators accumulate in the nerve connection and accelerate transmission nerve impulse. These means include:

• Amitriptyline, Doxepin, Imipramine
• Desipramine, Trimipramine, Nortriptyline

Because of this group has quite a lot of medicines side effects(dry mouth and mucous membranes, constipation, difficulty urinating, heart rhythm disturbances, hand tremors, blurred vision), it is used less and less.

Selective serotonin reuptake inhibitors

• Sertraline - Aleval, Asentra, Zoloft, Seralin, Stimuloton
• Paroxetine - Paxil, Rexetine, Adepress, Plizil, Actaparoxetine
• Fluoxetine - Prozac, Fluval, Prodel
• Fluvoxamine - Fevarin
• Citalopram - Oprah, Cipralex, Selectra

Such antidepressants are preferable for neurotic depression accompanied by fears, aggression, etc. The side effects of these medications are not extensive. The main one is nervous excitement. But large doses or overdose can lead to the accumulation of serotonin and serotonin syndrome.

This syndrome is manifested by dizziness, trembling of the limbs, which can develop into convulsions, increased blood pressure, nausea, diarrhea, increased motor activity, and even mental disorders.

That is why popular and good antidepressants like fluoxetine (Prozac), which enterprising pharmacists sometimes sell without a prescription, when taken uncontrolled or in excess of doses, can lead a person from banal mood disorders to a convulsive attack with loss of consciousness, hypertensive crisis or hemorrhage in the brain, or even to the point of “going crazy.”

Selective serotonin and norepinephrine reuptake inhibitors

They work similarly to the drugs of the previous group. Milnacipran and venlafaxine are indicated for depression with obsessive-compulsive disorder or phobias. Among the side effects they are characterized by: headache, drowsiness, anxiety.

Heterocyclic antidepressants

Heterocyclic antidepressants (with receptor action) are preferable in the elderly and when depression is combined with sleep disorders. Cause drowsiness, may increase appetite and promote weight gain.

• Mianserin (Lerivon), Nefazodone
• Mirtazapine (Remeron), Trazodone (Trittico)

Monoamine oxidase inhibitors

Drugs of choice for depressive disorders with panic attacks, fear of open spaces, with psychosomatic manifestations (when depression provokes internal illnesses). They are divided into:

• irreversible - Tranylcypromine, Phenelzine
• reversible - Befol, Pyrazidol (Normazidol), Moclobemide (Aurorix)

Serotonin reuptake activators - new generation antidepressants

Able to overcome symptoms of depression in one week. They are effective for somatized depression with palpitations and headaches. They are also used for depression of an alcoholic nature or depression with psychosis due to disorders cerebral circulation. But these drugs can be addictive like opiates, they include: Tianeptine (Coaxil).

These strong antidepressants They stopped selling them without prescriptions after many lovers of inexpensive highs used them “for other purposes” for several years throughout the post-Soviet space. The result of such experiments was not only multiple inflammations and vein thrombosis, but also a shortening of life to 4 months from the start of systematic use.

Antidepressants of different groups

• Buspirone (Spitomin), Nefazadone
• Heptral (see)
• Bupropion (Wellbutrin)

List of new generation antidepressants

The most popular drugs today are from the group of selective serotonin and norepinephrine reuptake blockers.

• Sertraline(Sirlift, Zoloft, Stimuloton) is the “gold standard” in the treatment of depression today. Other drugs are compared with it in terms of effectiveness. Preferred in the treatment of depression combined with overeating, obsessive disorders and anxiety.
• Venlafaxine(Venlaxor, Velaxin, Efevelon) - prescribed for depression against the background of more severe mental disorders(for example, schizophrenia).
• Paroxetine(Paxil, Rexetine, Adepress, Sirestill, Plizil) - effective for mood disorders, melancholy and inhibited depression. It also relieves anxiety and suicidal tendencies. Treats personality disorders.
• Opipramol – best option for somatized and alcoholic depression, as it inhibits vomiting, prevents convulsions, stabilizes vegetative nervous system.
• Mild antidepressants- This is fluoxetine (Prozac), which is somewhat weaker, but milder than other serotonin uptake inhibitors.

Antidepressants and tranquilizers: difference between groups

In addition to antidepressants, tranquilizers are also used in the treatment of depression:

• This group of drugs eliminates feelings of fear, emotional stress and anxiety.
• At the same time, the medications do not impair memory and thinking.
• Additionally, tranquilizers can prevent and relieve seizures, relax muscles, and normalize the functioning of the autonomic nervous system.
• In medium doses, tranquilizers reduce arterial pressure, normalize heart rate and blood circulation in the brain.

Thus, tranquilizers mainly differ from antidepressants by their opposite effect on the autonomic nervous system. Also, tranquilizers have the greatest effect on fear and anxiety, which can be eliminated even with a single dose, while antidepressants require course treatment. Tranquilizers are more likely to cause addiction and their withdrawal symptoms are more pronounced and severe.

Basic by-effect groups are addictive. Drowsiness, muscle weakness, prolonged reaction time, unsteadiness of gait, speech disturbances, urinary incontinence, and weakened libido may also develop. In case of overdose, paralysis may develop respiratory center and respiratory arrest.

When abruptly stopping tranquilizers after long reception withdrawal syndrome may develop, manifested by sweating, trembling of the limbs, dizziness, sleep disturbances, intestinal dysfunction, headache, drowsiness, increased sensitivity to sounds and smells, tinnitus, disorders of perception of reality, depression.

Overview of herbal antidepressants (without a prescription)

Antidepressants often include herbal sedatives, which are not antidepressants at all:

• Preparations of Valerian, Melissa, Peppermint, Motherwort
• Combined tablets - Novopassit, Persen, Tenoten - These are sedatives that will not help with depression.

The only thing medicinal plant with antidepressant properties - these are perforatum and drugs based on it, which are prescribed for mild depressive conditions.

There is one thing: to eliminate the manifestations of depression, synthetic drugs, which are tens of times more effective than St. John's wort, you have to drink in courses for several months. Therefore, St. John's wort will have to be brewed, infused in kilograms, and consumed in liters, which, naturally, is inconvenient and impractical, although it can somewhat distract from sad thoughts about the frailty of all things during depression.

The pharmacological industry offers St. John's wort in tablet form without a prescription as a mild antidepressant (nootropic) for psychovegetative disorders, neurotic reactions, mild depressive states - these are Deprim, Neuroplant, Doppelhertz nervotonic, Negrustin, Gelarium. Since the active substance in the drugs is the same, the contraindications, side effects, and interactions with other drugs of these drugs are similar.

Deprim Ingredients: dry standardized extract of St. John's wort. It has a pronounced sedative effect, since the active substances of St. John's wort - pseudohypericin, hypericin, hyperforin and flavonoids - have a positive effect on functional state CNS and autonomic nervous system. Increases physical activity, improves mood, normalizes sleep. Indications: sensitivity to weather changes, depression mild degree, anxiety states, Contraindications: severe depression, tablets are contraindicated for children under 6 years of age, capsules for children under 12 years of age, hypersensitivity - allergic reactions to St. John's wort and components of the drug, the effect of the drug on the fetus - there are no reliable studies, therefore it is not prescribed during pregnancy and lactation. Dosage: from 6 to 12 years only under the supervision of a doctor, 1-2 tablets in the morning and evening, adults: 1 capsule or tablet 1 r/day or 3 r/day, possibly 2 tablets 2 times a day. The effect occurs after 2 weeks of use, do not take double dose in case of missed appointment. Side effects: constipation, nausea, vomiting, anxiety, feeling tired, itchy skin, redness of the skin, photosensitivity - simultaneous use of the drug and sunbathing can lead to (see). Tetracyclines, thiazide diuretics, sulfonamides, quinolones, and piroxicam especially enhance photosensitivity. Overdose: weakness, drowsiness, side effects increase. Special instructions: the drug should be prescribed with caution simultaneously with other antidepressants, oral contraceptives (see), not prescribed simultaneously with cardiac glycosides, cyclosporine, theophylline, indinavir, reserpine. Enhances the effect of analgesics, general anesthesia. During use, you should avoid drinking alcohol, staying in the sun, etc. UV irradiation. If there is no improvement after a month of taking it, stop taking it and consult a doctor.

Neuroplant 20 tab. 200 rub. Ingredients: dry extract of St. John's wort herb, ascorbic acid. Indications and contraindications similar to the drug Deprim. In addition, Neuroplan is strictly contraindicated for children under 12 years of age, women during pregnancy and breastfeeding, with increased photosensitivity, and is prescribed with caution for diabetes mellitus. Dosage: It is better to take before meals, do not chew, but take 1 tablet whole with water. 2-3 times a day, and if there is no effect within several weeks of use, the drug is discontinued and treatment is adjusted. Side effects: indigestion, skin allergic reactions, psycho-emotional stress, apathy, . Concomitant use with other drugs: reduces the concentration of hormonal contraception and increases the risk of occurrence. At simultaneous administration with antidepressants the likelihood of side effects increases - causeless fear, anxiety, vomiting, nausea, as well as a decrease in the effect of amitriptyline, midazolam, nortriptyline. When taken with drugs that increase photosensitivity, the risk of photosensitivity increases. Neuroplant reduces therapeutic effect indinavir and other HIV protease inhibitors, drugs used to treat cancer that inhibit cell growth.

Doppelhertz neurotonic 250 ml. 320-350 rub. Ingredients: Elixir Doppelhertz Nervotonic - liquid extract St. John's wort, as well as cherry liqueur concentrate and liqueur wine. Indications and contraindications Deprim and Neuroplant are similar. Additionally: Doppelhertz Nervotonic should be taken with caution for brain diseases, liver diseases, traumatic brain injuries, and alcoholism. Side effects: rarely allergic reactions, in persons with fair skin with a tendency to photosensitivity - photosensitivity reaction. Application: 3 times a day, 20 ml. after eating for 1.5 -2 months, if there is no effect, you should consult a doctor. Special instructions: Like other drugs with St. John's wort extract, interactions with other drugs should be taken into account when taken simultaneously. The drug contains 18 vol.% ethanol, that is, when taking the recommended dose, 2.8 g of ethanol enters the body, so driving Vehicle and you should refrain from working with other mechanisms that require quick psychomotor reactions (driving a car, working as a dispatcher, working with moving mechanisms, etc.)

Negrustin Negrustin capsules - dry extract of St. John's wort herb Negrustin solution - liquid extract of St. John's wort herb Indications, contraindications and side effects similar to other St. John's wort preparations. Dosage: children over 12 years of age and adults, 1 capsule 1-2 times a day or 3 times a day, 1 ml. solution, course of therapy 6-8 weeks, possible repeated courses. Capsules should be taken during meals with liquid; the solution can also be taken diluted or undiluted during meals. Special instructions: Like other drugs with the active ingredient of St. John's wort extract, caution should be exercised when used together with the drugs listed above. Negrustin solution contains sorbitol and delivers 121 mg of it at each dose. The drug is also prescribed with caution to persons with fructose intolerance. Negrustin, with the simultaneous use of alcohol or tranquilizers, affects a person’s psychophysical abilities (driving vehicles and working with other mechanisms).

Gelarium Dragee Gelarium Hypericum is a dry extract of St. John's wort herb. Indications, contraindications, side effects, interactions with other drugs is similar to all drugs with St. John's wort. Application: 1 tablet 3 times a day over 12 years of age and adults, for a course of at least 4 weeks, during meals, with water. Special instructions: the break between taking the above drugs (if taken simultaneously) should be at least 2 weeks; for diabetes mellitus, it should be taken into account that a single dose contains less than 0.03 XE.

Herbal medicines with St. John's wort are widely available in pharmacy chains, the price is 20 filter bags or 50 grams. dry matter 40-50 rub.

The first antidepressants were synthesized in the fifties of the twentieth century. Nowadays, pharmacological companies continue to work on the creation of new groups of antidepressants, taking into account modern scientific ideas about mental illness. These medications affect the painfully depressed mood that is observed with.

How do antidepressants work?

Mental illnesses, including depression, are still largely unexplored territory. There are many hypotheses explaining the nature of these diseases. According to the generally accepted monoamine theory of depression, the disease occurs due to a deficiency of monoamine neurotransmitters (serotonin, dopamine, norepinephrine). Accordingly, in order to overcome depression, it is necessary to restore the normal metabolism and balance of these neurotransmitters. This is the mechanism of action of antidepressants.

Neurotransmitters- these are substances that transmit information from a neuron to another cell (nervous, muscle, etc.). The contact area between these cells is called a synapse. Neurotransmitters are produced in the presynaptic membrane of the neuron. Then from there they are released into the synaptic cleft - the space between neighboring neurons. Most neurotransmitters enter the adjacent neuron through the postsynaptic membrane. A minority of the remaining neurotransmitters are captured back into the presynaptic membrane. According to the monoamine theory of depression, the disease causes increased reuptake of monoamine neurotransmitters, in particular serotonin. That is, neurotransmitters are produced, but do not reach their destination. Because of this, it is disrupted mental activity, apathy and bad mood appear.

Such a group of antidepressants as selective serotonin reuptake inhibitors (SSRIs) it precisely prevents the reuptake of this neurotransmitter by the presynaptic membrane. That is, the amount of serotonin in the synaptic cleft increases, and accordingly the postsynaptic membrane receives it in the proper amount. This is how the antidepressant effect is realized.

There is also such a group of antidepressants as monoamine oxidase inhibitors (MAO). Monoamine oxidase is an enzyme that breaks down monoamine neurotransmitters. Thus, the use of MAO inhibitors helps to suppress the activity of this enzyme, which is why neurotransmitters are not destroyed and, accordingly, their concentration increases.

Types of antidepressants

Exist various classifications antidepressants. This is how the classification looks like according to the mechanism of action of drugs:

1. Drugs that block the neuronal uptake of monoamine neurotransmitters
   • Non-selective (non-selective) actions that block the reuptake of serotonin and norepinephrine (Amitriptyline, Imipramine);
   • Selective (selective) actions that block the capture of only a specific neurotransmitter:
     • Blocking serotonin reuptake, this group is also called SSRIs (Fluoxetine, Paroxetine, Citalopram);
     • Blocking norepinephrine reuptake (Maprotiline).
2. Monoamine oxidase inhibitors (MAO):
   • Non-selective action (Nyalamide);
   • Selective action (Pirlindol, Moclobemide).
3. Various (blocker of serotonin and alpha2-adrenergic receptors - the drug Mianserin, agonist of melatonergic receptors - Valdoxan).

In addition, there is also a classification of antidepressants according to their effect. Antidepressants, in addition to their own antidepressant effect, have additional action: sedative or psychostimulant. Based on this, we distinguish antidepressants predominantly with a sedative effect(Amitriptyline, Mianserin), predominantly with a psychostimulating effect(Fluoxetine, Moclobemide). There are also balanced antidepressants (Paroxetine, Sertraline, Duloxetine). The doctor takes these aspects into account when selecting a drug for a particular patient, because for some, depression occurs with apathy, slowing of motor and mental activity, and for others with high anxiety and psychomotor agitation.

Indications for use

Just by the name of the group of drugs, you can understand that they are used in the fight against depression. However, the range of prescriptions for modern antidepressants, namely SSRIs, is quite wide. They are also prescribed for the following conditions:

• Anxiety disorder;
• Panic disorder;
• Obsessive-compulsive disorder;
• Complex.

Thus, SSRI antidepressants are widely used in general medical practice. Antidepressants are prescribed by a doctor and only if there are objective indications.

Many people are afraid to take antidepressants, even despite doctor's orders. They are driven by fears caused by popular myths about these drugs. So, many people believe that antidepressants are drugs that you can’t get off later.

In fact, antidepressants are not drugs. Their use can only influence pathologically depressed mood. They do not cause euphoria and are not able to improve the mood of people who do not suffer from depression. That is, if a healthy person takes an antidepressant, he will not feel any effect. In addition, antidepressants are not addictive .

Features of application

The use of antidepressants has its own characteristics. We are so designed that we want to immediately get rid of it with one pill. unpleasant symptoms. However, this will not work with antidepressants. The fact is that the antidepressant effect when using this group of drugs occurs after approximately two to three weeks.

Much earlier, the additional effect of the drug is realized: calming or stimulating. This is why SSRI antidepressants are used in the treatment of anxiety disorders, because anxiety and restlessness decrease quite quickly.

Note! Due to the fact that the antidepressant effect does not develop immediately, many people stop taking the medication on their own, considering it useless. You can't do that. You can definitely say about the effectiveness of the medicine after a month. If the medicine really turns out to be ineffective, the doctor will replace it with another medicine.

The dose of the medication is increased gradually, reaching the required clinical effect. That is, the dose is selected individually for each patient. The course of taking antidepressants is quite long. Initially, their use is aimed at eliminating the painful condition; this takes an average of two to three months. After eliminating depressive symptoms, antidepressants are not stopped and are taken as maintenance therapy for another four to six months. If the condition normalizes, the doctor discontinues the drug. This should be done gradually, gradually reducing the dose of the medicine. In general, the course of taking an antidepressant is at least six months. Sometimes treatment can take a year or even two.

Important! The path to recovery from depression can be quite long, but you shouldn’t give up. By following your doctor's instructions and working on yourself, you can get rid of painful symptoms and enjoy life again!

Side effects

First generation antidepressants(tricyclic antidepressants, irreversible MAO inhibitors) had many side effects. These are urinary retention, orthostatic hypotension, edema, cardio- and hepatotoxic effects, headaches, tremor,.

Antidepressants last generations have fewer side effects, but they still need to be taken into account. First of all, at the beginning of treatment with the drug, increased anxiety, restlessness, etc. may be observed. This is due to the stimulating effect of the drug. To prevent such side effects, antidepressants are often prescribed with tranquilizers for initial stage. Treatment should take place under the supervision of a doctor.

Side effects of SSRI inhibitors are also due to the fact that serotonin receptors are found in many organs. Receptor stimulation can cause the following side effects:

• , constipation;
• Daytime sleepiness;
• Apathy;
• Fast fatiguability;
• Tremor;
• Sweating;
• Decreased libido, anorgasmia.

Side effects occur in the first weeks of treatment and usually disappear as therapy continues.

Note! The use of any antidepressants carries a risk of developing manic states. Therefore, antidepressants should be used with caution in bipolar disorder.

Popular drugs

The most modern and widely used antidepressants are SSRI drugs. They are tolerated by patients much better than antidepressants of other groups. Their use has fewer contraindications and side effects. In addition, they can be used not only for depression, but also for anxiety disorders.

Amitriptyline

A drug from the group of tricyclic antidepressants (TCAs). Available in tablet form and solution for injection. The medicine quickly has a pronounced antidepressant effect. It also has a calming, anti-anxiety, and hypnotic effect.

Amitriptyline is less tolerated by patients than SSRIs. Its main side effects are:

• Dry mouth;
• Pupil dilation;
• Violation of eye accommodation;
• Constipation;
• Urinary retention;
• Hand tremors;
• Violations heart rate.

Amitriptyline is contraindicated in high intraocular pressure, cardiac conduction disorders, prostate adenoma, epilepsy.

The drug is not as widely prescribed as SSRIs. Amitriptyline is used in the treatment of severe endogenous depression. Treatment with the drug should be carried out in a hospital under the supervision of a doctor.

Fluoxetine

This is a popular SSRI antidepressant, also known by the trade name Prozac. The drug normalizes mood, reduces anxiety and fear. However, fluoxetine is classified as a psychostimulant antidepressant. Accordingly, it is prescribed for depression that occurs with a slowdown in motor activity and thought processes. In patients with psychomotor agitation and severe anxiety, the drug may aggravate pathological symptoms. Prescribed for moderate depression and anxiety disorders. Suitable for outpatient treatment.

The drug does not cause orthostatic hypotension and does not have a toxic effect on the heart, unlike Amitriptyline. However, taking Fluoxetine is not without side effects at all. These may include headaches, daytime sleepiness, nausea, vomiting, and dry mouth.

Cipralex

Belongs to the SSRI group, the active substance is escitalopram. Indicated for depression and panic disorder. The antidepressant effect develops after approximately 2-4 weeks. In the treatment of panic disorder of maximum therapeutic effect can be achieved after three months of treatment.

The medicine is used with caution when treating people with,.

Paroxetine

The drug belongs to the SSRI group and has a pronounced anti-anxiety effect. The range of applications of Paroxetine is very wide: from depression to post-traumatic stress disorder. This medicine is preferred for anxiety disorders. In case of depressive disorder with motor retardation and apathy, the drug can aggravate these symptoms.

Grigorova Valeria, medical observer

Helps you escape depression medications: Mild antidepressants without a prescription, sold in pharmacies. Psycho-emotional exhaustion affects performance, general state of life, mood, and attitude towards others. Chemical processes that occur in the brain imbalance the health of internal organs, launching new chains of pathological metabolic processes.

Causes of depression

A depressed, depressed state can be caused by various factors, although it manifests itself with similar symptoms:

• Situational depression develops in response to the inability to solve any life problem, stress, severe shock, dissonance between desires and results;
• Somatized depression is manifested by additional pathological processes in the work of internal organs;
• Hormonal depression is the body's response to sharp fluctuations hormones during pregnancy, after childbirth, with internal endocrine disorders.

Depression is expressed by a decrease in the level of endorphins and enkephalins, reluctance to change anything, apathy, indifference to what is happening, increased irritability, and fatigue.

Serious violations They are treated by specialists and medications are taken strictly as prescribed by the doctor.

You can get out of a depressed state and motivate yourself to overcome the difficulties that have arisen with the help of over-the-counter medications.

Depression pills without prescription

Are antidepressants sold without a doctor's prescription? Self-medication is not encouraged in any area of ​​medicine, but if you choose antidepressants yourself, you should give preference to the new generation of drugs.

1. Quickly affects the body;
2. No or minimal side effects;
3. Combines well with other medications;
4. Non-addictive long-term use

Depending on the effect the drugs have on the body, they are divided into three groups:

• Calming
• Stimulating
• Complex

Sedatives sedatives relieve irritability, anxiety, and save from insomnia and headaches.

Stimulating drugs are required for people who fall into apathy, melancholy, melancholy, who are unable to cope with the lack of motivation for active life, work and rest.

Depending on the active substance, which forms the basis of the drug, are distinguished:

• Tricyclics
• Selective serotonin reuptake inhibitors
• Serotonin reuptake activators
• Selective serotonin, norepinephrine uptake inhibitors
• Heterocyclic drugs
• Monoamine oxidase inhibitors
• Complex antidepressants

Group of tricyclic antidepressants

Amitriptyline– tablets and solution for intramuscular injections, providing sedative effect. It is used for manic-depressive psychoses, bulimia nervosa, and enuresis. Reduces diuresis, relieves pain. The list of side effects includes fatigue, drowsiness, hallucinations, nervous excitability, disorientation, tachycardia, nausea, speed dial weight.

Doxepin indicated for depression, neurosis and neurosis-like conditions, anxiety against their background, psychosis, alcohol addiction, organic lesions brain It is used to treat panic conditions and sleep disorders due to neurotic reactions. Has an analgesic and antipruritic effect.

Imipramine has been used for a long time and is considered one of the first drugs for treating depression. It has a stimulating effect, improves mood, increases body tone, relieves melancholy, lethargy, and lethargy. Appointed as part of complex therapy for the treatment of migraine, consequences of head injury, drug addiction, panic attacks.

Despite the fact that the drug for depression is prescribed in small doses even in childhood, it has a large list of side effects, contraindications, and is not compatible with all medications. Treatment should be discontinued by gradually reducing the dosage. Its analogue is desipramine.

Nortriptyline– a medicine for endogenous depression, used as part of complex therapy with other drugs.

Side effects include dry mucous membranes, urinary retention, heart rhythm disturbances, tachycardia, nervous agitation, loss of orientation, and hallucinations.

Group of selective serotonin reuptake inhibitors

Drugs in this group are used for disorders accompanied by obsessive states, fears, phobias, and panic attacks.

Incorrect dosage is manifested by tremors of the limbs, even convulsions, tachycardia, dizziness, vomiting, and a sharp rise in blood pressure.

This group includes:

• sertraline,
• paroxetine,
• fluoxetine,
• fluvoxamine,
• citalopram and their analogues.

It has become quite a popular tool Prozac:

• Heals obsessive states;
• Relieves feelings of anxiety and uncertainty;
• Relieves symptoms of PMS;

Like many antidepressants, it is contraindicated during pregnancy and breastfeeding.
Medicines from the group act similarly selective inhibitors capture of serotonin, norepinephrine.

Group of heterocyclic drugs

Medicines in this group treat, along with depressive disorders, sleep and appetite disorders, recommended for older people.

This group includes:

• Mianserin
• Nefazodone
• Remeron
• Trittico

Group of monoamine oxidase inhibitors

Medicines effective for panic attacks, somatic depression, fear of open spaces.

This group includes:

• phenelzine,
• befol,
• moclobemide and their analogues.

As a result of taking it, anxiety decreases, social adaptation improves, and the desire to live is restored. The most popular and in demand in modern medical practice are new generation drugs.

Antidepressants without prescriptions of herbal origin

Herbal preparations widely used in complex therapy for the treatment of depression. Most of them provide sedative effect due to natural ingredients:

1. Deprim is a drug based on St. John's wort. It has an antidepressant effect, stabilizes sleep, and increases activity. Indicated for depression, anxiety, weather dependence, and during menopause. Analogues of Deprim are such drugs as Neuroplant, Doppelhertz Nervotonic, Negrustin, Gelarium;
2. Complex drugs, which include mint, lemon balm, valerian - novo-passit, persen and other medicines, the names of which are often heard in television advertisements. They cannot be called full-fledged antidepressants, but they will help with insomnia, stress, increased anxiety, fatigue, irritability;
3. Preparations based on hawthorn, motherwort, and peony calm the nervous system;
4. Preparations based on Leuzea increase performance, relieve fatigue and lethargy;
5. Good antidepressants are medicines based on ginseng. However, it is recommended to use them in the cold season, since skin cells become very sensitive to sun rays, the risk of skin pigmentation increases.

How to diagnose depression?

The diagnosis of depression and everything connected with it, in Lately sounds more and more often.

In some ways, depressive states have become “fashionable”: accelerated rhythm life modern man, stress at work and at home, increased loads and the responsibility associated with them - all this leads to mental exhaustion and moral burnout.

In our country, psychoanalysis is not as popular as in the West, so it is easier to diagnose yourself and prescribe treatment in accordance with Internet recommendations.

When choosing antidepressants you need to be very careful! Even herbal medications, which cannot be called antidepressants in the full sense, have a list of side effects.

Medications usually:

• Contraindicated for children and adolescents;
• Prohibited for pregnant women;
• Not recommended during breastfeeding;
• Use with caution when chronic diseases internal organs, endocrine diseases, mental disorders

In many cases, when treating depressive conditions associated with decreased vitality, lethargy, melancholy, apathy, irritability, and sleep disorders, you can get by with “light artillery”: sedatives, immunomodulatory drugs.

In cases where clinical picture causes concern, you should seek help from a specialist. Most “serious” drugs are sold in pharmacies with a doctor’s prescription.

After an examination and history taking, he will be able to decide what medications are needed in a particular case, in what dosage and for how long.

Certain medications cannot be discontinued abruptly; the dose must be reduced gradually.

Depression interferes with socialization and adaptation, disrupts the usual rhythm, changes a person’s mood, character and habits.

For minor disorders, you can purchase good over-the-counter antidepressants. But in case severe violations competent medical care is needed.

In the pharmacy you can find antidepressants without prescriptions that help normalize sleep, relieve depression and relieve anxiety. Such new drugs affect the exchange of mediators in the brain (norepinephrine and serotonin).

The use of such drugs stimulates human psyche. But what strong antidepressants to choose? Below we will offer a list of drugs that you can take without fear of side effects.

Antidepressants available to everyone

You can only buy light pills without a doctor's prescription, which can also have a positive effect on your mood. Here are the names of the medicines, tablets of which can be purchased over the counter. What products are these, and why you don’t need a prescription to buy them.

Maprotiline (Lyudiomil)

Choosing best antidepressant, pay attention to this tetracyclic drug. With its help, you can lift your mood, eliminate apathy, anxiety, and stabilize psychomotor retardation. Speaking about side effects, this drug should not be taken during pregnancy, liver dysfunction, or kidney disease.

Prozac (Fluval, Prodep, Profluzac, Fluoxetine)

These over-the-counter antidepressants belong to the group of selective serotonin inhibitors (SSRIs). Such names are often used by neurologists and therapists. The effect of the drugs is achieved in the treatment of menstrual disorders, elimination of anxiety and panic conditions, improves mood, and can be used to get rid of obsessive thoughts. If you take such medications regularly, you can achieve a balanced psyche and improve your mood.

Zyban (Nousmoke, Wellbutrin)

Paxil (Sirestill, Rexetine, Plizil, Adepress)

Taking tricyclic antidepressants brings good effects; such drugs are often prescribed to be taken in the doctor's office. You can take medications such as antidepressants and anti-anxiety medications. If we talk about side effects and consequences, then it does not affect the functioning of the heart and psychomotor functions. Can be taken to correct heart function. Recommended to drink when stressful situations, depression, different types of phobias.

Deprim

Taking antidepressants of this type improves mood and performance. Such medicines contain St. John's wort, which has good effect.

Persen

When choosing treatment with antidepressants, you can opt for Persen. The drug provides a high effect and contains natural ingredients ( peppermint, valerian, lemon balm). Lifts your mood and fights stress.

Novo-Passit

The action of antidepressants of this type has a pronounced sedative effect. Such medicines contain passionflower, hops, guaifenesin, lemon balm, elderberry, St. John's wort and hawthorn. You can take medications when you need to relieve anxiety, tension, headaches, and alleviate premenstrual and climatic syndromes.

Herbal antidepressants

New generation antidepressants may contain medicines, they have a good effect and almost complete absence side effects. It is recommended to drink such remedies when you need to cope with depression and anxiety that appears against the background of worries and stress.

• Infusions of immortelle, rhodiola rosea, maralia root, lemongrass - these remedies eliminate the feeling of overwork. The drugs should be taken before meals, 150 grams;
• Alcohol extract of Leuzea - ​​such drugs stimulate human psychometric functions, improve mood, increase performance;
• Ginseng tincture can have an effect in the form of stimulation immune system. It treats symptoms of depression and increases the body's resistance to stress. Side effects should be noted increased sensitivity to the sun. It is not recommended to go to the solarium if you decide to drink ginseng tincture;
• Zamanikha - can be used to increase performance, improves mood, normalizes sleep;
• Motherwort, oregano, blue honeysuckle, red clover. Such remedies allow you to get rid of depression;
• Hawthorn produces a calming effect;
• Hops, peppermint, valerian are excellent herbal antidepressants that do not have any particular side effects;
• Medicinal angelica works great against insomnia;
• You can drink calendula to relieve fatigue and tension.

These herbal medicines can be used exclusively for moderate and mild severity of the disease. They have an effect on sleep disorders, restlessness, and anxiety.

Another indication for treatment with herbal remedies is various psychovegetative disorders. This is a series of conditions in which the pathology of internal organs is not detected during examinations, and the manifestations themselves are formed as consequences of disturbances in the functioning of the nervous autonomic system. They include:

• A feeling of lack of air;
• Head pain and dizziness;
• Pain in the abdomen and heart;
• Cardiopalmus;
• Disorders of bowel movement and urination.

Antidepressants based on St. John's wort have virtually no side effects and can be used without a doctor's prescription. But in the case of more severe depressive conditions, such remedies will not bring effective result. In such conditions, the assistance of the attending physician and the prescription of antidepressants of a different category are necessary.

Security measures

Many people have various mental disorders. Unfortunately, people who are constantly in stressful situations, at work, at home and even on vacation, are familiar with the problems of sleep disturbances and irritability. Women usually, at the first signs of depression, try to take medications without thinking about the consequences; men “kill their nerves.”

You should not shy away from the help of a psychiatrist. Similar drugs without a prescription may not help if there are factors causing pathology. Only after it has been determined can you begin to take medications. In other cases, the disease will develop into chronic form with intervals of remissions and exacerbations.

Before you try to purchase new generation antidepressants in the public domain, think about the side effects. Can you distinguish neurosis from depression?

It may be better to visit a professional doctor who can rule out the negative effects of medications on your body.

Even herbal preparations have a number of side effects if used incorrectly.

Medical statistics say that the majority modern people Those who buy a variety of sedatives do not suffer from mental problems. Such patients create a mindset of depression within themselves and try to recover from the imaginary condition.

People who feel depressed and are unable to cope with it need help, which can be provided by certain medications, including over-the-counter antidepressants.

Strictly speaking, self-medication with antidepressants is not the most best idea, because the patient cannot take into account all the factors and features pharmacological treatment what self-assignment does prescription drugs dangerous to health. But sometimes it is impossible to see a doctor for some reason, but help is still needed. What can be done in this case?

The most effective ways to solve the problem are the support of relatives and the help of a specialist (psychologist, psychotherapist or psychiatrist, depending on the person’s condition and the cause of the illness). Apathy, indifference and lack of positive emotions are characteristic features of depression. Sometimes it is difficult to overcome the overwhelming hopelessness, so drug treatment is required.

Each person experiences stress and depression differently. Depression can be accompanied by various manifestations:

• irritability;
• loss of appetite;
• sleep disturbance;
• anxiety;
• apathy;
• fear;
• yearning;
• tearfulness;
• skin rashes;
• disruption of the digestive system;
• allergy.

In addition, it may appear increased sweating, tachycardia and even shortness of breath. If there are three or more signs, you should consult a doctor who, after examination and clarification of the circumstances, will recommend which drug is most suitable.

Most psychoactive drugs should be taken according to a special regimen, dosages should be strictly observed, first gradually increasing them, then decreasing them using the same method. Many medications have a cumulative effect, requiring time for them to take effect and time for the patient to feel well without them.

But in cases where only the first signs of the disease are observed, over-the-counter antidepressants, weaker medications with fewer side effects, are quite appropriate.

Important! Whether a prescription is required to use the drug or not, a strict rule must be followed - only a doctor can prescribe the drug. The doctor determines the dosage and duration of the course.

The main difference between medications that are sold freely in pharmacies is that they are intended for mild depression, or subdepression - a short-term decrease in mood.

The composition of the products may be different, they differ from each other chemical formula, main active substances and additional components.

Unites them minimal amount side effects and contraindications. As a rule, antidepressants without a doctor's prescription are based on plants. But even if the composition includes artificially synthesized chemical elements, their concentration makes the drug harmless.

Strong antidepressants without prescriptions are a myth. MAOIs, tricyclics, SOZS and other neurotransmitter retake inhibitors are not sold without a special document from a psychiatrist.

What drugs can be purchased without a prescription?

The list of such funds is quite extensive. Medicines that can lift your mood, reduce irritability, improve sleep and restore appetite are not necessarily powerful. You can change your condition for the better with the help of mild antidepressants and herbal-based sedatives.

Below are the medications that are most popular.

Deprim

Herbal remedy based on St. John's wort herb extract. Additional components are stabilizers. Preservatives and fillers are intended for the production of solid dosage forms. Also contains lactose and calcium dihydrate.

The drug normalizes the functionality of the nervous system, improves sleep and mood due to the substances contained in the plant:

1. A phloroglucinol derivative, hyperforin, is a powerful inhibitor of a group of neurotransmitters. It is a strong anxiolytic and antidepressant that activates receptor potential ion channels. In addition, the element has antibiotic properties and is active against strains of staphylococcus resistant to methicillin. It is also able to remove inflammation.
2. Another substance, hypericin, improves the functioning of the autonomic and nervous systems. Affects dopaminergic structures, converting this hormone into norepinephrine. Thanks to the element, mild and moderate depression can be easily cured.

A significant advantage of the drug Deprim is the combination of high safety and effectiveness and low cost. The price for a pack of medicine containing two blisters of 15 tablets is 250 rubles.

It is prescribed in the following cases:

• emotional exhaustion;
• chronic fatigue;
• depression;
• weather dependence;
• mood swings during menopause.

The composition is prescribed for oral administration. The dosage is 1-3 tablets three times a day, depending on age. The therapeutic effect is observed 10 days after the start of use. The general course of treatment is a month.

Contraindications for use are as follows:

• age up to 6 years;
• depression with suicidal tendencies;
• intolerance to components.

In most cases, the drug is well tolerated, but if the dosage is exceeded, side effects may develop in the form of dyspeptic disorders and allergies.

Important! Deprim should not be combined with cyclosporine and theophylline. It is strictly forbidden to drink alcohol during treatment.

In addition to Deprim, drugs such as Negrustin, Gelarium and a number of others have been created based on St. John's wort. Doctors emphasize that there have been no reliable and large-scale studies on the effectiveness and side effects of these herbal medicines.

Persen

This mild antidepressant is on the list of medications most often prescribed by psychiatrists. It contains three types of plant extracts:

• Melissa;
• valerian;
• peppermint.

Available in tablet form, it acts as an antispasmodic, quickly eliminates irritability and calms. In addition, the drug provides complete sleep without causing daytime drowsiness. The effectiveness of the composition is due to valerian, which contains alkaloids and essential oils. The plant relieves vasospasm and nervous excitement.

Melissa is an antispasmodic and antidepressant, which also has anxiolytic and immunomodulatory properties. The natural substance not only soothes and restores stable emotional condition, also fights viruses and germs. The plant improves appetite and helps eliminate signs of toxicosis during pregnancy.

Terpenoids and menthol, which are contained in mint, have a beneficial effect on emotional background and relieve headaches.

The leaves are used during menopause and for stress as a sedative. The substance also helps prevent anorexia, protects against infections and inflammatory processes.

Persen is indicated when there is no need to use potent drugs, it is used in the following cases:

• neuroses;
• when withdrawing sedatives;
• disorders in the autonomic nervous system;
• during menopause;
• for the prevention of pathologies in people with poor resistance to stress.

The medicine is well tolerated, there are very few side effects. These include allergic manifestations and constipation with long-term use. It is contraindicated for the following conditions and diseases:

• lactose and fructose intolerance;
• the presence of stones in the gall bladder and kidneys;
• pregnancy;
• lactation period;
• low blood pressure.

Also not prescribed for children under 12 years of age. The dosage is 2-3 tablets in several doses per day. For insomnia, you should take the medication an hour before going to bed. The course of treatment should last no more than 90 days. The average cost of a package with 40 tablets is 300-400 rubles.

For reference! Persen can enhance the effect of antihypertensive, hypnotic and analgesic compounds, so dose adjustments are required.

Novo-Passit

This medication contains whole list medicinal herbs with different properties:

1. Hawthorn. This plant began to be used in medical purposes back in the 16th century. It was originally intended as an astringent for diarrhea. Later, its ability to purify the blood and have a beneficial effect on blood vessels was discovered. The plant contains flavonoids and hydroxycinnamic acids, which explains its functions as a cardiotonic,
2. St. John's wort is a natural antidepressant from the Malpighiaceae genus. This perennial shrub in extract form is effective for anxiety disorders, improves emotional well-being, and eliminates depression and depression. It is often used in therapeutic complexes for alcohol, drug and drug addiction.
3. A plant of the passionflower family, passionflower contains glycosides, saccharides, and amino acids. It has been used in sedatives for a very long time. Helps with sleep disorders, seizures and even epilepsy. Eliminates fear and nervousness, effective for irritability. In combination with hawthorn it has an enhanced effect.
4. Hops belong to the genus of flowering hemp plants. Contains anthocyonides, catechins, phenolcarboxylic acids. Considered soft sedative, which is slightly inferior to the pi strength of valerian. Suppresses the activation of chemical carcinogens and prevents angiogenesis. Hops also prevents the development of tumors.
5. Medicinal essential oil herbaceous lemon balm - another natural antidepressant and anxiolytic. The plant is able to fight viruses and bacteria and protects against infections. In addition, it stimulates immune mechanisms and helps strengthen the body. The herb increases appetite and performance, improves mood.
6. A flowering plant of the Adoxaceae family, elderberry disinfects, relieves inflammation and helps in the treatment of gout and rheumatism. The spectrum of its action is quite extensive. Elderberry copes well with pain of various etiologies, removes anxiety, fear and apathy. In addition, it is suitable for improving metabolism and treating skin pigmentation disorders.

In addition to plants, the drug contains the main active substance – guaifenesin. This element is considered a mucolytic, which helps evacuate secretions in respiratory diseases. But in combination with herbs, it exhibits sedative properties and eliminates feelings of melancholy and depression.

Indications for the use of Novo-Passit are as follows:

• neurasthenia;
• migraine;
• mental stress;
• syndromes during menopause;
• sleep disorders;
• functional disorders of neuroendocrine regulation;
• fatigue;
• decreased performance and attention.

The list of contraindications is short. This is myasthenia gravis and intolerance to any of the components of the medication. It is also not prescribed to children under 12 years of age. Therapy for alcoholism and serious pathologies digestive system.

It cannot be said that this is the cheapest drug; the cost varies between 300-330 rubles. for 300 ml of syrup and 170-200 rubles. for 10 tablets.

For reference! Novo-Passit should be taken with caution in case of epilepsy and after head injuries. In such cases, the doctor adjusts the duration and dosage regimen.

At simultaneous use With muscle relaxants, a side effect such as muscle weakness may occur. Also reduces exposure hormonal contraception, which must be taken into account when receiving.

Afobazole

This drug is more likely to be an anxiolytic with a neuroprotective effect that protects cells from damage. It has a dual effect on the nervous system. At the same time relieves anxiety and depression and stimulates memory, emotions and motor skills.

Its functions are based on that. that it prevents changes in receptors that occur during the activity of gamma-aminobutyric acid, an inhibitory neurotransmitter. The result is a sedative and muscle relaxant effect.

A distinctive feature of the medication is that, according to the manufacturer, it helps to get rid of excessive suspiciousness and uncertainty, while memory and concentration remain within normal limits.

The first result is observed already on the fifth day of treatment, and the full therapeutic effect appears after 4 weeks and lasts for another 14 days after discontinuation of the drug.

The medication is well absorbed and distributed throughout systems where it binds to protein compounds. It is also quickly eliminated from the body, which virtually eliminates complications after an overdose. Its price for 690 tablets is 350-400 rubles.

Indications for the use of Afobazole are as follows:

• anxiety states of various etiologies;
• mental disorders;
• neuroses;
• disorders of the autonomic and vascular system;
• premenstrual syndrome;
• menopause period;
• alcoholism treatment;
• irritability associated with quitting smoking.

Do not take the drug during pregnancy and lactation. Do not prescribe the medicine if you are hypersensitive to its components. It is also contraindicated for children. Adverse reactions are associated with intolerance to the substances included in the composition, expressed in allergic manifestations and dysfunctions of the digestive system.

The optimal dosage is 10-30 mg per day, divided into three doses. The course of treatment lasts 4 weeks, but in some cases the doctor can extend it to 3 months.

If there is a need to take medicine while breastfeeding, lactation will have to be abandoned. With simultaneous consumption of alcohol, the toxic effect on brain cells, A therapeutic properties drugs are leveled out.

The pharmaceutical industry offers a huge list effective means for the treatment of depression. If depression has just begun to manifest itself, over-the-counter antidepressants based on herbal ingredients. But even such safe compounds should be prescribed by a doctor, as they can also cause adverse reactions and have contraindications.

Important! Even with mild emotional disorders the help of a specialist (psychotherapist or psychiatrist) should not be avoided. If the cause is not identified, taking the most effective medications will be useless or even harmful.

Many people, in the slightest stressful situations, grab pills without even really understanding whether they can be taken and what will happen after that.

It is necessary to understand that anxiety states differ from neuroses, and depression differs from mental disorders. And only a doctor can deal with the patient’s problems and help eliminate them without negative consequences.

Ask an expert a question in the comments