What does Teraflex Advance help with? Teraflex Advance side effects. Special patient groups

The most popular chondroprotector in modern Russian market consider Teraflex Advance. Medicines in this group are intended for the treatment of ailments of the musculoskeletal system and their prevention. The pharmacological industry produces a lot of similar medications, why should you choose Theraflex Advance?

The medicine has a number of advantages that have a beneficial effect on the patient's condition. The features of the medication, the method of its use, the pros and cons of the drug are described in the following material.

Benefits and composition of the drug

Teraflex Advance is a combination medicinal product that includes chondroitin, ibuprofen, and chondroitin sulfate. Each component is responsible for a separate function, the complex effect provides quick, lasting results:

  • chondroitin sulfate. It is an indispensable component of cartilage tissue, triggers its regeneration processes, protects against damage, and has a beneficial effect on the mobility of joints in the human body;
  • glucosamine Designed to stimulate the formation of components of articular membranes, cartilage tissue, such as hyaluronic acid, proteoglycans and others;
  • Ibuprofen belongs to the group of anti-inflammatory drugs non-steroidal drugs that have an analgesic effect.

The presence of such components allows us to consider Teraflex Advance a full-fledged medicinal product and not a dietary supplement. The drug has several effects at once: it copes with pain, restores cartilage tissue, relieves swelling and inflammation, and increases the mobility of the damaged joint.

Important! The medicine has a number of contraindications, avoid side effects Strict adherence to the recommendations specified in the instructions and a preliminary consultation with a doctor will help. Teraflex Advance is often used in complex therapy joint diseases, in rehabilitation period after surgery.

Indications for use

Doctors recommend taking medicinal product for elimination degenerative changes in the cartilage tissue of joints. Often, the medication is prescribed for osteoarthritis of large joints, and less often for osteochondrosis, which is accompanied by severe pain in the back. Active components cope with pain syndrome, eliminate inflammatory process.

Go to the address and read about what Achilles bursitis of the calcaneus is and how to treat the pathology.

Price

Each package includes 30, 60, 120 capsules. It is not profitable to buy a small pack, and it is also difficult to find in a pharmacy. The drug for 60 capsules costs approximately 650–800 rubles, the price of Teraflex Advance 120 capsules is up to 1350 rubles. Taking into account the frequency of administration (up to six capsules per day), it is advantageous to purchase a large package, which will be enough for the recommended course of three weeks.

The specific amount of the drug depends on the city of purchase and the pharmacy chain. Do not take risks by buying a medicine that is too cheap, it is probably of poor quality. Be sure to check the expiration date and absolute integrity of the packaging.

Drug analogues

Not all patients are suitable for the relatively high cost of Teraflex Advance, so searching cheap analogue becomes task number one. Before purchasing, pay attention to the composition of the medication; in most cases, the high cost is due to additional components that most often provoke the development of allergies.

The pharmacological industry produces a lot of similar products, identical to Teraflex Advance is ARTRA, it costs three times more, it is available cheap analogue of Indian origin - CONDROnova, it is produced in the form of capsules and ointments. Some patients prefer to replace complex medicine means containing only one component of the drug:

  • Glucosamine include Elbona, Chondroxide Maximum and others;
  • Ibuprofen is represented by the well-known Nurofen;
  • Chondroitin sulfate – Chondrolone, Chondrogard, Mucosat.

In most cases, the total cost of all the above drugs is much higher than purchasing one package of Teraflex Advance. There is no point in saving so much; it is easier to buy one effective medicine.

Teraflex Advance is very popular, despite its rather high cost. Some patients report side effects. They are associated with individual intolerance to individual components of the medication or exceeding the dosage or taking the drug for too long. The medicine does its job well and is easy to take.

A preliminary consultation with your doctor and compliance with the rules specified in the instructions will help you avoid unwanted effects. Teraflex Advance helps cure ailments of the musculoskeletal system, quickly relieves pain, starts regenerative processes in cartilage tissue. The main thing is to use the medicinal product correctly.

Catad_pgroup Chondroprotectors

Teraflex Advance - official instructions for use

Registration number:

LS-002678

Trade name of the drug:

Teraflex® Advance

International nonproprietary name:

Glucosamine + Ibuprofen + Chondroitin sulfate.

Dosage form:

Capsules.

Compound:

1 capsule contains:
active substance: glucosamine sulfate in the form of D-glucosamine sulfate, potassium chloride 250 mg, chondroitin sulfate sodium 1 200 mg, ibuprofen 2 100 mg.
Excipients: microcrystalline cellulose 17.4 mg, corn starch (pregelatinized starch) 4.1 mg, stearic acid 10.2 mg, sodium carboxymethyl starch 10 mg, crospovidone 10 mg, magnesium stearate 3 mg, silicon dioxide 2 mg, povidone 0.3 mg .
Gelatin capsule: gelatin 97.07 mg, titanium dioxide 2.83 mg, brilliant blue dye aluminum varnish 0.09 mg.
1 chondroitin sulfate sodium contained in the form of 90% of the substance, taking into account 10% loss in weight during drying and excess - 241 mg;
2 ibuprofen contained in the form of directly compressed granules 66%, containing: ibuprofen 66%, pregelatinized starch 8%, croscarmellose sodium 2%, microcrystalline cellulose 14%, colloidal silicon dioxide 1%, stearic acid 1.5%, corn starch 6%, povidone 1 .5% - 152 mg.
Ink composition: shellac NF, dehydrogenated ethyl alcohol USP, isopropyl alcohol USP, butyl alcohol NF, propylene glycol USP, ammonia solution NF, indigo carmine aluminum varnish, titanium dioxide USP.

Description:

Opaque hard gelatin capsules size No. 0, consisting of two parts: a blue cap and a body white, with an inscription of blue color"THERAFLEX ADVANCE", filled with white or almost white powder with a slight odor.

Pharmacotherapeutic group:

Tissue repair stimulator + non-steroidal anti-inflammatory drug.

ATX code:

M01AE51

Pharmacological properties

Pharmacodynamics

Teraflex® Advance is combination drug, containing chondroitin sulfate, glucosamine sulfate and ibuprofen as active ingredients. Chondroitin sulfate is involved in the construction and restoration of cartilage tissue, protects it from destruction and improves joint mobility.
Glucosamine sulfate activates the synthesis of proteoglycans, hyaluronic, chondroitinsulfuric acids and other substances that make up the joint membranes, intra-articular fluid and cartilage tissue.
Ibuprofen is a derivative of propionic acid and has analgesic, antipyretic and anti-inflammatory effects due to the indiscriminate blockade of cyclooxygenase 1 and 2. Glucosamine sulfate and chondroitin sulfate contained in the drug potentiate the analgesic effect of ibuprofen.
Pharmacokinetics

Bioavailability of glucosamine at orally- 25% (first pass effect through the liver), the highest concentrations are found in the liver, kidneys and articular cartilage. About 30 % dose taken persists for a long time in bone and muscle tissue. It is excreted mainly in urine unchanged, partially in feces. The half-life is 68 hours.
More than 70% of chondroitin sulfate is absorbed in the digestive tract. Bioavailability is about 13%. With a single oral administration of an average therapeutic dose, the maximum concentration in plasma is observed after 3 - 4 hours, in the synovial fluid after 4 - 5 hours. The drug absorbed in the gastrointestinal tract accumulates in the synovial fluid. Excreted by the kidneys.
Ibuprofen is well absorbed from the stomach. Tmax - about 1 hour. Ibuprofen is approximately 99% bound to plasma proteins. It is slowly distributed in and cleared from synovial fluid more slowly than from plasma. Ibuprofen is metabolized in the liver primarily by hydroxylation and carboxylation of the isobutyl group. The CYP2C9 isoenzyme takes part in the metabolism of the drug. After absorption, about 60% of the pharmacologically inactive R-form of ibuprofen is slowly transformed into active S-form. Ibuprofen has biphasic elimination kinetics. The half-life (T½) from plasma is 2 - 3 hours. Up to 90% of the dose can be found in urine in the form of metabolites and their conjugates. Less than 1% is excreted unchanged in urine and, to a lesser extent, in bile. Ibuprofen is completely eliminated within 24 hours.

Indications for use

Osteoarthrosis of large joints, osteochondrosis of the spine, accompanied by moderate pain.

Contraindications

Hypersensitivity to any of the ingredients included in the drug. History of hypersensitivity to acetylsalicylic acid or other NSAIDs. Erosive and ulcerative diseases organs gastrointestinal tract(including peptic ulcer stomach and duodenum in the acute stage, Crohn's disease, ulcerative colitis).
Complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses. Confirmed hyperkalemia.
Hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis.
Gastrointestinal bleeding and intracranial hemorrhage.
Heavy renal failure(creatinine clearance less than 30 ml/min), progressive kidney disease.
Severe liver failure or active liver disease.
Severe heart failure, period after aortotherapy coronary bypass surgery.
Pregnancy, lactation period. Childhood up to 18 years old.
Carefully

Old age, heart failure, arterial hypertension, liver cirrhosis with portal hypertension, liver and/or renal failure, nephrotic syndrome, hyperbilirubinemia, gastric and duodenal ulcers (history), gastritis, enteritis, colitis, blood diseases of unknown etiology (leukopenia and anemia), bronchial asthma, diabetes mellitus, concomitant therapy with anticoagulants, antiplatelet agents, glucocorticosteroids, selective inhibitors serotonin reuptake, peripheral arterial disease, moderate renal failure (creatinine clearance 30-60 ml/min), smoking, alcoholism, dyslipidemia/hyperlipidemia, ischemic disease heart disease, cerebrovascular diseases, Helicobacter pilori infection, long-term use of NSAIDs, tuberculosis, severe somatic diseases. If you are intolerant to seafood (shrimp, shellfish), the likelihood of developing an allergic reaction to the drug increases.

Use during pregnancy and breastfeeding

Not recommended for use during pregnancy and breastfeeding.

Directions for use and doses

Inside. Adults take 2 capsules 3 times a day after meals. Capsules are taken orally with a drink a small amount water. The duration of use without consulting a doctor should not exceed 3 weeks. Further use of the drug should be agreed with your doctor.

Side effect

When using the drug Teraflex® Advance, the following are possible: nausea, abdominal pain, flatulence, diarrhea, constipation, allergic reactions; these reactions disappear after discontinuation of the drug.
The possibility of development should be taken into account adverse reactions associated with ibuprofen present in the drug.
Gastrointestinal tract (GIT): NSAID gastropathy (abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation; rarely - ulceration of the gastrointestinal mucosa, which in some cases is complicated by perforation and bleeding); irritation or dryness of the mucous membrane oral cavity, pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis, pancreatitis, exacerbation of colitis and Crohn's disease.
Hepatobiliary system: hepatitis.
Respiratory system: shortness of breath, bronchospasm.
Sense organs: hearing impairment (hearing loss, ringing or tinnitus); visual impairment (toxic damage to the optic nerve, blurred vision or double vision, scotoma, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids of allergic origin).
Central and peripheral nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, rarely - aseptic meningitis (more often in patients with autoimmune diseases).
The cardiovascular system: development or worsening of heart failure, tachycardia, increased blood pressure, increasing the risk of arterial thrombosis.
urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
Allergic reactions
: skin rash (usually erythematous or urticaria), pruritus, angioedema, anaphylactoid reactions, anaphylactic shock, dyspnea, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis.
Blood-forming organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.
Others: increased sweating.
Laboratory indicators : bleeding time (may increase), serum glucose concentration (may decrease), creatinine clearance (may decrease), hematocrit or hemoglobin (may decrease), serum creatinine concentration (may increase), liver transaminase activity (may increase), urea concentration in the blood (may increase), bilirubin concentration in the blood (may increase).

Overdose

Symptoms (associated with ibuprofen)
: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased blood pressure, renal tubular acidosis, hypokalemia, hyperkalemia, bradycardia, tachycardia, atrial fibrillation, respiratory arrest.
Treatment: gastric lavage (effective only within 1 hour after administration), Activated carbon, alkaline drinking, forced diuresis, symptomatic therapy(correction of acid-base status, blood pressure).

Interaction with other drugs

Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of ibuprofen, increasing the risk of severe hepatotoxic reactions.
Microsomal oxidation inhibitors reduce the risk of hepatotoxicity. Reduces the hypotensive activity of vasodilators (including slow calcium channel blockers and ACE inhibitors), natriuretic and diuretic - furosemide and hydrochlorothiazide.
Reduces the effectiveness of uricosuric drugs, enhances the effect indirect anticoagulants, antiplatelet agents, fibrinolytics (increased risk of hemorrhagic complications), ulcerogenic effect with bleeding of glucocorticosteroids, NSAIDs, colchicine, estrogens, ethanol; enhances the effect of oral hypoglycemic drugs and insulin. Antacids and cholestyramine reduce the absorption of ibuprofen. Increases the blood concentration of digoxin, lithium and methotrexate. Caffeine enhances the analgesic effect.
When administered simultaneously, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (possibly increasing the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after starting ibuprofen).
The simultaneous use of drugs containing glucosamine and coumarin anticoagulants (for example, warfarin) can lead to an increase in INR and the risk of bleeding; it is necessary to monitor blood coagulation parameters.
When prescribed with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding simultaneously increases.
Cefamandole, cefoperazone, cefotetan, valproic acid, plicamycin increase the incidence of hypoprothrombinemia.
Myelotoxic drugs increase the manifestations of hematotoxicity. Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by increased nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase plasma concentrations of ibuprofen.
Due to the glucosamine content in the drug, the effectiveness of hypoglycemic drugs, doxorubicin, teniposide, and etoposide may be reduced. Glucosamine increases the absorption of tetracyclines and reduces the effect of semisynthetic penicillins and chloramphenicol.
Joint reception with potassium-sparing diuretics increases the risk of hyperkalemia. NSAIDs may decrease the effect of mifepristone.
Concomitant use of NSAIDs and tacrolimus may increase the risk of nephrotoxicity.
Co-administration of zidovudine increases the risk of hematological toxicity of NSAIDs.
Concomitant use of quinolones and NSAIDs increases the risk of seizures.

special instructions

During long-term treatment painting control is required peripheral blood And functional state liver and kidneys.
When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a blood test with determination of hemoglobin, hematocrit, stool analysis occult blood.
If necessary simultaneous administration additional NSAIDs and analgesic drugs, the doctor should take into account the presence of ibuprofen in the drug. If necessary long-term use For additional NSAIDs, use Teraflex®, which does not contain ibuprofen.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.
During the treatment period, alcohol intake is not recommended.

Effect on ability to drive vehicles and mechanisms

During the treatment period, you should refrain from driving vehicles and performing actions that require concentration or psychomotor reactions.

Release form

Capsules 250 mg + 100 mg + 200 mg. 30, 60, 120 capsules are placed in a polyethylene bottle high density with screw cap made of polypropylene. The neck of the bottle is sealed with a protective membrane. The lid and neck of the bottle are sealed with transparent film.
Each bottle along with instructions for use medical use placed in a cardboard box.

Storage conditions

At a temperature not higher than 25°C.
Keep out of the reach of children.

Best before date

2 years.
Do not use after expiration date.

Vacation conditions

Over the counter.

Manufacturer

Owner registration certificate:
JSC "BAIER", Russia

Produced:
Contract Pharmacal Corporation, 135 Adams Avenue, Hoppaugh, New York 11788, USA

Organization receiving consumer complaints:
JSC "BAIER", Russia
107113, Moscow, st. 3rd Rybinskaya, 18, bldg.

Teraflex is a fairly popular and widespread drug for the treatment various diseases joints, which simultaneously includes two active ones -. It is the content of two active components that is the distinguishing feature this drug. In addition, Teraflex, unlike most standard chondroprotectors, is available not only in tablets, but also as an ointment (Teraflex - M), but in this case the effectiveness of the drug is somewhat reduced, and the price is higher.

There is also Teraflex-Advance, reviews of which from doctors and patients are mostly positive, and the price is about 10% lower. His main distinguishing feature— a non-steroidal anti-inflammatory drug has been added to the composition of two chondroprotectors. This gives such a medicine some advantage of an “instant” effect, since the chondroprotectors themselves remove painful sensations only after a certain period of time, when they accumulate in the body in sufficient quantities, and NSAIDs act almost immediately, reducing pain syndrome.

However, it should be borne in mind that non-steroidal anti-inflammatory drugs have one unpleasant effect - they contribute to the destruction of cartilage tissue. One of the two components of the medicine must cope with this unpleasant effect, but this somewhat reduces its effectiveness. In addition, it has a number of side effects that appear with prolonged use (mainly from digestive tract), which contradicts the basic principle of taking chondroprotectors (they only give effect over a long course - about six months). This imposes serious restrictions on the use of the drug Teraflex Advance; the instructions for use of this drug also emphasize the limited period of its use.

Form of release of the medicine and order of administration

The release form of Teraflex Advance is tablets or hard opaque gelatin capsules, which consist of a white body and a blue cap. The capsules also have the inscription “TERAFLEX ADVANCE” in blue. The capsules contain a heterogeneous white powder. Available in bottles of 30, 60 and 120 capsules.

One capsule of the drug contains 250 mg of glucosamine sulfate, 200 mg of sodium chondroitin sulfate, 100 mg, as well as a number of excipients (cellulose, pregelatinized and corn starch, stearic acid, crospovidone, sodium carboxymethyl starch, magnesium stearate, silicon dioxide and povidone).

The prescription of the drug and the determination of the order of administration should be carried out by a doctor. In general, adults take 2 capsules 3 times a day. The duration of taking the drug should be no more than 3 weeks, after which use can be continued only in consultation with the doctor.

It should be noted that tablets are taken in this way, Teraflex ointment is used somewhat differently, it has its own instructions for use.

Indications and contraindications

Indications for the use of the drug Teraflex Advance - and, which is accompanied by moderate pain.

However, there are quite a lot of contraindications to the use of this medicine, most of which are due to the presence of a non-steroidal anti-inflammatory drug. Thus, the use of the drug is contraindicated in:

  • “aspirin” asthma;
  • erosive and ulcerative diseases of the gastrointestinal tract;
  • bleeding disorders;
  • for intracranial hemorrhages and gastrointestinal bleeding;
  • at hypersensitivity to the ingredients that make up the drug;
  • with hypersensitivity to NSAIDs.

The use of this drug is also contraindicated for pregnant women and during lactation, as well as for children under 12 years of age (since the effect of the drug on the child’s body has not been studied).

Side effects

Although this medicine If all instructions are followed, it is usually well tolerated; side effects still occur in some cases. Most of them are associated with the presence of non-steroidal anti-inflammatory substances in the drug, and accordingly, symptoms most often appear in the gastrointestinal tract. So, it may be discomfort or pain in the stomach area, increased gas formation, loose stool or constipation.

In some cases there are side effects and from the central nervous systems s - dizziness, headache, insomnia or drowsiness.

It is also possible to develop symptoms such as various allergic reactions (redness, itching, urticaria), swelling of the legs and the appearance of pain in the legs.

Prices and analogues

As mentioned above, the instructions for use of the drug Teraflex Advance assume that taking this drug will not be too long, so after a few weeks the patient will begin to be interested in the price of analogues of this medicine. It should be noted that this arrangement of ingredients is quite unusual, therefore there are practically no similar drugs. If we consider medications that simultaneously contain two chondroprotectors, then the choice is small - basic Teraflex (without the Advance prefix) or, and there is little point in discussing which is better - they are almost identical in composition.

Now let's look at prices. Teraflex Advance is available in bottles of 30, 60 and 120 capsules. But it’s simply not profitable to buy the smallest bottle (and it’s difficult to find such packaging), but a package of 60 capsules, depending on the region, can cost from 650 to 800 rubles, a package of 120 capsules - from 1200 to 1350 rubles. But here you should take into account the high rate of intake (6 capsules per day for three weeks - this is approximately the same large bottle of 120 capsules).

Drugs that are analogues (basic Teraflex and Artra) are much more expensive (for a bottle of 30 capsules of Teraflex - from 650 to 800 rubles, 60 capsules - 900-1200, 120 capsules - 1200-1400), but here it should be taken into account that the rate at which they are taken is significantly lower (halved), and there is no need to change the drug.
For the reasons described above, Teraflex Advance is usually prescribed only during periods of exacerbation, and the rest of the time doctors prefer to use its analogues.

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Sedentary lifestyle modern man leads to the fact that an increasing number of people are faced with dysfunction of the musculoskeletal system, diseases of the spine and joints. The American anti-inflammatory drug Teraflex Advance can help cope with these problems - the instructions for use of this drug indicate that the analgesic effect of Ibuprofen in its composition helps reduce pain.

What is Teraflex Advance

A drug prescribed for inflammatory diseases musculoskeletal system, Teraflex Advance is a drug produced in the form of gelatin capsules. The active ingredients in its composition relieve the inflammatory process and participate in the restoration of damaged cartilage tissue. The doctor may recommend that the patient take Teraflex with Ibuprofen for osteoarthritis and osteochondrosis medium degree heaviness with moderate pain.

In addition to these diseases, this remedy can be prescribed to a patient for inflammation of the joints accompanied by pain. Indications for use according to the instructions:

  • degenerative-destructive diseases skeletal system;
  • post-traumatic conditions;
  • intra-articular inflammatory processes.

The difference between Teraflex and Teraflex Advance

Drugs called Teraflex have the same indications for use, as indicated in their instructions. They have the same release form - capsule, with a similar number of capsules in the package. Differences between Teraflex and Teraflex Advance - main active ingredients and possible Negative consequences applications. Ibuprofen has been added to Advance - a substance NSAID groups(nonsteroidal anti-inflammatory drugs), which reduces fever and is a strong analgesic. The volume of chondroitin sulfate also differs - there is more of it in regular Teraflex than in Advance.

Since the concentration of basic substances in regular Theraflex is higher, it is recommended for use for long-term systematic treatment chronic conditions. Advance is prescribed for withdrawal acute attacks. Teraflex Advance has a number of side effects that Teraflex does not have, since the concentration of active ingredients is lower and Ibuprofen is present. When using Advance, allergic reactions are possible; it is contraindicated in patients with low blood clotting rates, respiratory diseases, and stomach ulcers.

Composition

The active ingredients of Teraflex are glucosamine sulfate, chondroitin sulfate sodium and ibuprofen. In addition, according to the instructions, the composition contains:

  • starch (gelatinized, corn and sodium carboxymetalized);
  • stearic acid;
  • silica;
  • magnesium stearate;
  • crospovidone;
  • povidone.

Thanks to the side components, the effect of the main ones is enhanced by increasing their absorption. The drug is quickly absorbed and easily excreted from the body. Chondroitin and glucosamine are chondroprotectors of artificial origin - their components can stimulate the restoration of cartilage tissue.

Release form

There are no other forms of release of Teraflex other than encapsulated. One gelatin blue-white opaque capsule in a natural shell contains 600 mg of white powder with a slightly yellowish tint. The pharmacy will offer you three options for packaging the medicine - 30, 60, 120 capsules in one bottle. Focus on the expected duration of the course. Each unit of packaging is accompanied by instructions for use of the medicinal product.

How to use

According to the instructions for use, a daily dose of 6 capsules is recommended for adult patients, which should be divided into three doses. Theraflex should be taken after eating food with water. The manufacturer warns that without agreement with the attending physician, the duration of the course cannot exceed twenty-one days. Elderly people over sixty years of age should not take this medicine unless prescribed and monitored by their physician due to the strong side effects of ibuprofen.

Instructions for use

The instructions for use indicate two main diseases for which therapy using this drug is indicated: articular osteoarthritis and spinal osteochondrosis of all stages. However, thanks to the chondroprotectors included in the composition and their ability to heal cartilage tissue, it is practiced to prescribe the drug during the treatment of fractures and sprains.

The bioavailability of the main substances is: up to 30% for glucosamine and up to 15% for chondroitin. The highest concentration after absorption through the gastric mucosa occurs in intra-articular synovial fluids, cartilage tissue and liver. Its maximum level is reached within four hours after administration. The total half-life from the body can be up to three days. Ibuprofen binds to plasma proteins and, after being metabolized by the liver, is excreted from the body within twenty-four hours.

During pregnancy

The use of Teraflex during pregnancy and breastfeeding is strictly contraindicated. Ibuprofen is 95% bound to the plasma of the expectant mother. Once in the fetal body, it can cause irreversible damage during the formation internal organs, lead to damage to the nervous or cardiovascular systems child. If you have indications for the use of this drug, your doctor should suggest an alternative, gentle method of therapy.

Overdose

During long courses of administration exceeding 21 days, the risk of poisoning with subsequent intoxication of the body cannot be excluded. In case of overdose, the following symptoms may occur:

  • stomach ache;
  • renal failure;
  • tachycardia;
  • dizziness;
  • nausea and vomiting;
  • headache.

If you suspect an overdose, stop taking the drug, read the instructions for use again and consult your doctor. After gastric lavage, you will be prescribed therapy to restore the acid-base state and correct blood pressure. Cases of overdose may occur if the recommended dose is regularly exceeded. daily dose or during a long course of treatment. Accept medicine in strict accordance with the instructions of the instructions and your attending physician.

Side effects

When using the drug, side effects may occur. This happens because active substances its composition is potent, which increases the risk of disruptions to the gastrointestinal tract, respiratory, cardiovascular and nervous systems. When taking Theraflex, nausea, dizziness, attention deficit disorder, and abdominal pain are possible. If one or more of the signs described above appear, interrupt therapy and get tested to reduce the likelihood of developing serious complications.

Contraindications

Theraflex Advance is a potent drug, so there is an impressive list of diseases and conditions for which its use is strictly contraindicated. The instructions for use contain the following contraindications:

  • peptic ulcer of the stomach or duodenum;
  • colitis;
  • Crohn's disease;
  • bleeding disorders;
  • asthma;
  • gastrointestinal bleeding;
  • intracerebral hemorrhages;
  • liver and kidney diseases;
  • pregnancy and lactation period;
  • age under 18 and after 65 years;
  • period after coronary bypass surgery;
  • individual intolerance to the components of the drug and aspirin.

A connection has been identified between the body’s allergic reaction to seafood and to the components of the drug. If eating molluscs, crustaceans, shrimp, cephalopods and other sea creatures causes you discomfort, a reaction from the digestive or limbic systems of the body, there is a high probability of an allergy to this medical drug.

Interaction with other drugs

Teraflex Advance can be prescribed together with other medical supplies. The patient should be aware of possible consequences simultaneous therapy, since in this case, interactions with other drugs cannot be avoided. The main active ingredients of Theraflex can enhance or reduce the effect of vasodilators, hypoglycemic drugs, insulin, thrombolytic, anticoagulant agents. More detailed information about the interaction contains instructions for use.

Analogs

Russian analogues Teraflex Advance is inexpensive, contains the same active ingredients in different dosages, and also has a number of additional advantages, for example, it is available in the form of an injection solution. Analgesic effect intramuscular injection not as slow as when taking a capsulated drug, the activity of the main substance is higher.

To choose an analogue, focus on the composition and dosage of the active substance. Anti-inflammatory drugs for joints produced in Russia and Belarus are known and widely used:

  • Chondroglucide;
  • Chondrolone;
  • Chondroitin-AKOS;
  • Elbona;
  • Mucostat;

Price Teraflex Advance

This medicine is available without a doctor's prescription, so you can order it and buy it in an online store or at any pharmacy. In Moscow pharmacies, its price starts from 600-650 rubles for thirty capsules and reaches 2500-2900 for a pack of 120. On Internet resources and in pharmacy catalogs average price depends on packaging. You can buy Teraflex Advance from 30 capsules at a cost of 600-750 rubles per bottle, 60 - 1300-1750 rubles; 120 – 1900-2300 rubles. There are Russian and foreign analogues medicines that have a lower cost. Depending on the manufacturer and packaging, you can purchase a drug with a similar spectrum of action at a price almost half the price of Teraflex Advance.

Video

Latin name: Theraflex/ Theraflex M/
Theraflex Advance
ATX code: M01BX
Active substance: Glucosamine hydrochloride,
chondroitin sulfate sodium
Manufacturer: Sagmel, USA
Conditions for dispensing from a pharmacy: Over the counter

Teraflex capsules are a popular product that allows you to stimulate regeneration processes in cartilage tissues, as well as have an anti-inflammatory effect on affected tissues.

Release forms

The drug is available in three forms:

Tablets in the form of capsules with a hard gelatin shell. The contents are a white powdery mass with some crystals. There is no smell. The taste of the drug is specific, unexpressed.

Packaging: polyethylene bottles placed in cardboard boxes. Each bottle contains 30, 60 or 120 capsules.

The tablets are available in capsule form. The capsules have a hard gelatin shell and are transparent. Inside the capsule there is a powder with inclusions of small crystals, a white to yellowish-white powder. The smell may be completely absent, or it may not be pronounced or specific.

The taste is specific, typical for Ibuprofen tablets. Capsules are produced in polyethylene bottles, placed in thick cardboard boxes of 30, 60, 100 pieces.

The cream (ointment) is white to yellow-white in color and has a pronounced menthol smell. Application - external. Available in the form of plastic tubes of 56 and 28 g.

Medicinal properties

The active substance in the capsules of the drug chondroitin sulfate sodium acts as an additional substrate necessary for the reproduction of new cartilage matrices without defects, and also serves as a stimulator for the formation of hyaluronan, the synthesis of proteoglycon and type II collagens.

Due to suppression excessive activity Hyaluronidase chondroitin prevents the enzymatic breakdown of hyaluronon. Capsules containing Glucosamine sulfate serve as an activator of the synthesis of hyaluronic and chondroitisulfuric acids and proteoglycans, which are the main components of the membranes of joints, cartilage tissue and intra-articular fluids. Excreted in urine and feces.

The therapeutic properties of Teraflex Advance are similar to Teraflex, but the analgesic effect is more pronounced due to ibuprofen.

Ibuprofen, which the capsules contain, is characterized by antipyretic, anti-inflammatory and analgesic effects on the body. A successful combination of glucosamine sulfate and chondroitin sodium sulfate with ibuprofen enhances the anesthetic properties of the latter.

Cream "Teraflex M" improves regeneration processes in cartilage tissues and has an anti-inflammatory effect.

Chondroitin is involved in the process of cartilage tissue restoration. Suppresses active fermentation, which has a destructive effect on articular cartilage tissue, and stimulates its regeneration. Suppresses pain and improves joint functionality.

The cream contains glucosamine hydrochloride, which reduces glycosaminoglycan deficiency. The ointment suppresses the formation of enzymes and radicals, which have a detrimental effect on cartilage tissue.

The cream, due to the content of camphor, has an irritating effect on nerve cells subcutaneous tissue and the skin itself, which helps improve their blood circulation and acts as a local antiseptic. Mint has a good analgesic and antiseptic effect. A active substance excreted in urine.

Average price from 598 to 1867 rubles.

Compound

The capsule contains two active ingredients: glucosamine hydrochloride (500 mg) and sodium chondroitin sulfate (400 mg). TO excipients include stearic acid, manganese sulfate, magnesium stearate, croscarmellose sodium and gelatin.

Indications for use

Capsules are used as part of complex therapy for degenerative diseases of the joints and spine, such as osteochondrosis, osteoarthrosis of all degrees, arthrosis.

Mode of application

Orally. During the first three weeks of treatment, take 3 pcs. per day. Then - 2 for six months. The drug should preferably be taken half an hour after a meal, washed down with plain water.

This drug is prescribed as a supportive normal condition joints and spine remedies. During periods of exacerbation of pain in the affected areas, it is recommended to switch to Teraflex Advance, which includes ibuprofen.

Average price from 800 to 1930 rubles.

Compound

Capsule includes: glucosamine sulfate (250 mg), sodium chondroitin sulfate (200 mg), ibuprofen (100 mg), microcrystalline cellulose, corn starch, stearic acid, sodium carboxymethyl starch, magnesium stearate, silicon dioxide gelatin, titanium dioxide.

Indications for use

Teraflex Advance capsules are used for the treatment of degenerative diseases of the spine and joints: osteochondrosis, grade I-III osteoarthrosis, arthrosis. The medicinal product is prescribed for exacerbations of problems with the joints and spine, when the pain syndrome becomes more pronounced.

Reception scheme

Tablets (capsules) are taken orally (internal use). In the first three weeks of treatment for adult patients and children over 15 years of age, the medicine is prescribed in the amount of one capsule 3 times a day, after 21 days of treatment daily dosage decreases - one capsule 2 times a day. The tablets are washed down with water.

The course of treatment depends on general condition spine and joints and can range from 3 to 6 months. A repeated course of treatment, if necessary, is determined by the attending physician on an individual basis, but in any case, each subsequent course should be shorter in duration than the previous one.

"Teraflex M"

Compound

The cream contains (per 1 g): chondroitin (8 mg), glucosamine (3 mg), oil peppermint(9 mg), camphor (32 mg), aloe vera, macrogol, lanolin, cetyl alcohol, propylene glycol, dimethicone, purified water.

Average price from 245 to 498 rubles.

Indications for use

Cream (ointment) Teraflex M is used as a complex or self-treatment for diseases of the spine and joints. The indications for use are the same for the Teraflex capsule, the only difference is that the cream is applied externally. If we compare the compositions of both drugs, the active substances will be the same.

Reception scheme

The cream helps with spinal hernia and joint damage. It is used externally: rubbed into the skin of the affected area of ​​the spine or joints until completely absorbed 2-3 times a day. The annotation indicates that one rubbing requires 2 cm of ointment squeezed out of the tube.

Use by pregnant and lactating women

Due to the lack of reliable data regarding the safety of the drug "Teraflex" during pregnancy and breastfeeding It is prohibited to accept it. If the condition of a woman’s joints and spine during natural feeding requires immediate treatment, then lactation must be completed.

Contraindications

Despite the fact that Teraflex helps to carry out effective treatment joints, spine, it alleviates the patient’s condition with a hernia, but it cannot be taken in all cases. Contraindications include:

  • Children under 15 years old
  • Severe stages of renal failure
  • Pregnancy and lactation period
  • Intolerance/sensitivity (increased) to one or more components of the drug.

Precautionary measures

Capsules and ointment for patients suffering from any type of diabetes mellitus should be prescribed by the attending physician with extreme caution, adjusting the dosage individually and constantly monitoring the body's response to the use of the drug.

External use is not possible if there is mechanical damage skin, even minor ones.

Interaction with other drugs

  • At simultaneous use"Teraflex" with antibacterial drugs tetracycline type, the active substance of the first activates the absorption of antibiotics, which subsequently increases their concentration in the blood
  • The active substances of the drug can enhance the effect of drugs used to reduce blood clotting
  • Simultaneous use of the presented drug and penicillin antibiotics significantly reduces the expected therapeutic effect of the latter.

Side effects

"Teraflex", used for hernia, problems of the spine and joints, in some cases causes a number of side effects. The most common include nausea, abdominal pain, increased flatulence, diarrhea, constipation and various kinds allergic reactions.

Less common:

  • Bronchospasms and shortness of breath
  • Dizziness and headaches
  • Irritability and nervousness
  • Drowsiness
  • Visual and hearing impairments
  • Heartache
  • Rapid heartbeat (tachycardia)
  • Increased blood pressure
  • Polyuria and cystitis
  • Decreased iron levels in the blood
  • Decreased natural blood clotting
  • Decreased blood glucose levels.
  • Side effects in most cases disappear after some time has passed after stopping the drug.

Overdose

Cases of drug overdose are extremely rare. If the recommended doses are exceeded, manifestations of intoxication of the body in the form of nausea, vomiting, and hemorrhagic rash are possible.

Conditions and shelf life

Capsules and ointment for the treatment of joints and spine are stored for 3 years from the date of manufacture. Storage temperature - no higher than +25 C. It is better to choose a storage location away from direct sunlight.

Analogs

For arthrosis of any type, agents are used that normalize metabolic processes in the cartilage tissues of joints. There is no drug completely similar to Teraflex, but pharmaceutical market products similar in action and composition are presented: “Arthra”, “Arthrodol”, “Arthra MSM Forte”.

Unipharm, USA
Price from 700 to 2500 rub.

A drug that nourishes cartilage tissue, slows down its destruction and promotes its restoration (chondroprotector). Available in tablet form. Packs of 30, 60, 100 and 120 pieces.

pros

  • Ease of use
  • High efficiency.

Minuses

  • Inability to use for bronchial asthma and diabetes mellitus
  • Without additional analgesics, pain decreases only slightly.

Incampharm, Russia
Price from to rub.

The use of the drug helps restore the structure of cartilage tissue and improve joint mobility. Available in the form of ampoules for preparing a solution. Intramuscular injections. The package contains 10 ampoules, each 100 mg.

pros

  • In combination with others therapeutic measures gives good results
  • Convenient course of treatment - 1 course every six months.

Minuses

  • Painful injections
  • The need for systematic application.

Unpharm INC, USA
Price from 1740 rub.

Glucosamine and chondroitin sulfates enhance the analgesic effect of the drug. The drug also inhibits the progression of osteoarthritis and stimulates the regeneration of cartilage tissue. Improves blood flow in the subchondral bone. Reduces the need for non-steroidal anti-inflammatory drugs. Available in tablet form. There are 60 pieces in a package.

pros

  • High efficiency
  • No serious side effects.

Minuses

  • High cost of the drug
  • Long course of treatment.