Discounts for wholesale and regular customers. How to take Mexidol tablets before or after meals

To the question How prin. Mexidol (before, during or after meals)? Is it possible to apply it? simultaneously with Tanakan? Are there better drugs? Which? given by the author Vladimir Kudaev the best answer is Mexidol good drug(another similar Actovegin, about the same level). You can take it with tanakan. Take regardless of food.

Answer from 22 answers[guru]

Hello! Here is a selection of topics with answers to your question: As prin. Mexidol (before, during or after meals)? Is it possible to apply it? simultaneously with Tanakan? Are there better drugs? Which?

Answer from I-beam[newbie]
Method of administration and dose: IM or IV (stream or drip). When administered by infusion, the drug should be diluted in an isotonic sodium chloride solution.
Doses are selected individually depending on the pathology and severity of the patient's condition.
The recommended dose is 5-10 mg/kg/day, depending on the condition.
Mexidol is injected slowly over 1-3 minutes, dropwise at a rate of 40-60 drops per minute.
In the treatment of acute disorders cerebral circulation Mexidol is used intravenously in drops from 100 to 1000 mg/day, depending on the severity of the condition, for 10-14 days (the daily dose is divided into 2-4 injections), then intravenously in a stream or intramuscularly at 200 mg 2 times per day for another 10-14 days.
For acute traumatic brain injury, Mexidol is administered intravenously at a dose of 100-1000 mg/day, depending on the severity of the injury and the patient’s condition. The daily dose is divided into 2-4 injections.
For encephalopathies in the decompensation phase, Mexidol is used intravenously in a stream or drip at a dose of 200-300 mg 2-3 times a day for 10-14 days, then intramuscularly at 200-300 mg/day for 10-14 days.
For course prophylaxis for encephalopathies of various origins, Mexidol is administered intramuscularly at a dose of 200 mg 1-2 times a day for 10-14 days. In the future, they switch to using it in tablet form.
For vertebrobasilar insufficiency in the decompensation phase, Mexidol is administered 200 mg 2-3 times a day intravenously or intravenously, for 10-15 days; in the subcompensation phase - 200 mg 1-2 times a day intravenously or intramuscularly for 10-14 days with a further transition to the tablet form; in the compensation phase (preventive course) - 100-200 mg (1-2 amp.) IM daily for 10-15 days or in tablet form.
Epilepsy and episyndromes: 200-400 mg 1-2 times a day intravenously for 10-15 days, followed by transition to long-term oral administration.
For cognitive disorders of atherosclerotic origin in elderly patients, neurotic and psychoorganic syndromes - IM at a dose of 100-300 mg/day for 14-30 days, followed by switching to tablet form.
For alcohol and drug intoxication - IV drip at a dose of 300-400 mg 2-3 times a day until the intoxication is relieved.
For withdrawal syndromes (alcohol and drugs) - at a dose of 200-300 mg intravenously or intramuscularly 2 times a day for 5-7 days.
In case of acute intoxication with antipsychotic drugs - intravenous drip, in a daily dose of 400-800 mg, divided into 2 injections.
For asthenic disorders - at a dose of 100-200 mg/day IM daily for 10-15 days. Then they switch to tablet form.
For acute purulent inflammatory processes abdominal cavity (acute necrotizing pancreatitis, peritonitis) Mexidol is prescribed on the first day both in the preoperative and postoperative periods. The dose of the drug depends on the form and severity of the disease, the prevalence of the process, and variants of the clinical course. For acute edematous (interstitial) pancreatitis - 200-600 mg 2-3 times a day intravenously and intramuscularly. For necrotizing pancreatitis of mild severity - 200-400 mg 2-3 times a day intravenously and intramuscularly. For necrotizing pancreatitis medium degree severity - 200-600 mg 2-3 times a day intravenously; in case of a severe course of the process, on the first day a pulse dose of 800 mg is prescribed, divided into 2 injections, then 300 mg 2 times a day with a gradual decrease in the daily dose. In case of extremely severe necrotizing pancreatitis, the initial dose is 800 mg/day until the manifestations of pancreatogenic shock are persistently relieved, when the condition stabilizes - 300-400 mg 2 times a day intravenously, with a gradual reduction in the daily dose.
Course therapy with Mexidol is completed gradually, reducing the dose of the drug over 2-3 days.

Mexidol is a medication aimed at treating neuralgic diseases. The drug is characterized as a drug that has a nootropic and antihypoxic effect.

It has antioxidant and anxiolytic effects, and also has membrane stabilizing properties. Before use, you should familiarize yourself with how to take Mexidol in tablets, as well as the optimal dosages for using droppers and injections.

Mexidol contains the main active substance – ethylmethylhydroxypyridine. The latter contributes to the occurrence of the following processes in the body:

• Blocks and reduces the negative effects of free radicals on cells and soft tissue layers.
• Activates the protective properties of cell membranes, neutralizing the effects of various toxins.
• Acts as an anticonvulsant, increases resistance to hypoxia.
• It has a positive effect on the body during the treatment of pathogenic changes in the blood circulation of a chronic nature or the ongoing acute stage of the disease.
• Stimulates memory receptors, improving its functioning, increases cognitive function body and increases learning abilities.
• Due to stimulation of dopamine production, there are observed positive results in the treatment of uncomplicated depression.

The product increases resistance to external influences negative factors, as well as with a lack of oxygen during certain situations. Such pathogenic processes include:

• Stressful situations
• Sleep disturbance
• Brain injuries
• Intoxication
• Conflicts
• Hypoxia
• Physical and nervous overload

Mexidol is produced in the form of a solution and dragee. The solution can also be administered into gluteal muscle, as well as into a vein in the arm. Both medications contain identical main component– ethylmethylhydroxypyridine succinate. In dragees its volume is fixed at 125 mg, and in solution it is 1.5 times less - 50 mg.

Excipients additionally contained in the tablets are magnesium stearate and sodium carboxymethylcellulose, and lactose monohydrate is present. The specific tablet shell contains Opadry II white, talc, and also contains titanium dioxide and polyvinyl alcohol.

Each of the tablets has a convex, rounded shape on both sides. The color range of the shell varies from white-cream to whitish.

Indications for use of Mexidol

Coronary heart disease is one of the indications for the use of Mexidol

• , but in combination with the interaction of other drugs.
• Negative changes in the blood circulation of the head during the acute stages of the disease.
• For atherosclerosis of brain capillaries (dyscirculatory type encephalopathy).
• Anxiety in neurotic diseases.
• Traumatic brain injury and its consequences.
• Acute cardiac phase (use from the first moments of the situation).
• Cognitive disorders of atherosclerotic mild etiology forms.
• Intoxication with antipsychotic drugs.

In addition to the main indications for use of the drug, it is recommended to use it for the treatment of symptom complexes. The latter is provoked as a result of the negative impact on the nervous system of stressful situations and severe anxiety.

IN preventive measures Mexidol is often used by patients at risk of developing somatic diseases. The occurrence of diseases of this type is associated with a person receiving physical activity and exposure to extreme factors.

Contraindications to taking the medicine

Before use, you should consult your doctor to determine if there are any contraindications for use. It is strictly forbidden to administer medicine to patients with the following diagnoses:

• Acute renal failure
• Acute liver failure
• Increased hypersensitivity to the main ingredient of the drug or to auxiliary components

For patients with frequent and periodic surges in blood pressure, administration of the tablet form of Mexidol is permitted. But it is recommended to take it under strict dosage control and supervision of medical personnel.

Side effects from Mexidol and overdose

An overdose of Mexidol may cause stomach pain and other dyspeptic disorders.

Mexidol usually easily affects the body without causing side effects. Possible negative manifestations may occur due to individual intolerance. In this case, an allergic reaction to the administered drug may occur.

Failure to comply with the prescribed individual dosage leads to a dyspeptic reaction of the body to the administered drug.

In this situation, discomfort or pain in the stomach, a feeling of fullness in the area may appear. digestive organs, bloating and heartburn. There are cases of strong urge to vomit, changes in stool consistency, and frequent belching.

In some patients, it is possible to identify individual dyspeptic-type reactions, such as loss of appetite, rumbling in the intestines, lethargy, loss of ability to work, and increased flatulence.

If such reactions are detected, it is recommended to stop taking Mexidol. In the near future, you should consult a doctor to normalize the dosage or introduce substitutes for the active substance.

How to use Mexidol tablets

The duration of taking Mexidol tablets is determined by the attending physician

The tablet form of Mexidol is used only orally (by mouth). You should take the medication 3 times within 24 hours, 1-2 tablets per dose. The dosage per day should not exceed 800 mg; the recommended dose for treatment with tablets is from 375 mg to 750 mg.

To obtain a positive result, the initial dose is administered in a reduced dose in the amount of 1 tablet. The dose is gradually increased, reaching the required norm for an effective effect on the body.

The duration of tablet administration is regulated by the attending physician for each patient individually. All recommendations are issued based on the severity of the disease, as well as the identified examination results. The duration of taking tablets can be from 14 days to 45 days.

If the drug is used to eliminate alcohol withdrawal (withdrawal), then the duration of use of the drug is 5-7 days.

When canceling treatment, abrupt removal of the medication is unacceptable. The dosage should be reduced gradually, completely stopping treatment for 3 days.

In most cases, patients with myocardial disease are recommended to use the pills for treatment for 1-2 months. After examination by the attending physician, the course of therapy can be repeated if necessary. The optimal period for reproducing the treatment process is spring or autumn.

Method of using Mexidol in ampoules

Mexidol in ampoules is necessary for injection into the gluteal muscle or vein in the elbow. For intravenous injection, the drug is additionally diluted in 0.9% saline solution.

Jet injection is carried out quickly - within 6-7 minutes. Using the drip method, you should adjust the flow of the product into the vein within a minute from 40 to 60 drops. In this case, the maximum dosage for the dropper should not be higher than 1200 mg per 24 hours.

Basic doses for diseases

The dosage of the drug Mexidol depends on the disease for which it is used

For the treatment of various diseases, there are standard dosages necessary to obtain a positive effect. The following standards are identified for input depending on the disease:

1. acute stage: 5 days – intravenously, by drip at a dose of 100-150 mg, lasting up to 90 minutes. The next 9 days - intramuscularly. The substance should be administered 3 times a day with an interval of 8 hours, while the daily dose for therapy should be calculated from the norm of 6-9 mg per 1 kg of patient weight, but not more than 250 mg at a time.
2. Encephalopathy: 2 weeks of intravenous injection of 250-500 mg, 1-2 times per 24 hours. Afterwards, the dosage is reduced to 100-250 mg per day for the next 14 days.
3. Acute changes in blood circulation in the brain: Administration by drip into the cubital vein in a dose of up to 500 mg 3-4 times, for 1.5-2 weeks. Over the next 2 weeks, the dosage should be reduced by half.
4. Anxiety disorders and mild cognitive dysfunctions: intramuscularly for 2-4 weeks, 150-300 mg per day.
5. Traumatic brain injury and its consequences: drip injection into a vein on the elbow two to four times a day, at a dose of 250-500 mg.
6. Intoxication with anti-psychotic drugs: up to two weeks, the norm is 200 to 500 mg intravenously.

Thus, a specific disease requires an individual dosage and method of application. Individually selected doses have the most positive effect on the course of the disease, neutralizing symptoms and blocking further development.

Medicine and driving, use during pregnancy and lactation, use in pediatrics

Due to insufficiently studied effects and lack of studies in children and pregnant women, the use of the drug for the treatment of patients in this category is not recommended.

For the treatment of children in pediatrics, the use of Mexidol is permitted only in the case of cranial brain injuries and in the treatment of purulent neuroinfections. Input and monitoring of the child’s condition should be carried out by the attending physician.

Interaction of tablets with other drugs

Mexidol is not prohibited for administration together with other psychotropic drugs. In addition, the medication increases the effect of carbamazepine, benzodiazepines, and drugs for the treatment of Parkinson's disease.

The drug enhances the effect of tranquilizers and pain relievers. Affects an improved result after the introduction of anticonvulsants medicinal substances. Reduces the effect of ethyl alcohol on the body.

Mexidol analogues

Glycine is considered an analogue of Mexidol

If any contraindications or allergic reactions individual type, the attending physician can prescribe drugs that have a similar spectrum of action and have an identical effect on the body as the original. The following similar substitutes for Mexidol are distinguished:

• Mexiprim
• Mexicofin
• Medomexy
• Cerecard
• Mexicor
• Neurox
• Armadin
• Mexipridol
• Hypoxene
• Mexi B6
• Cerebronorm
• Glycine
• Polyneurin

Medicines can be easily purchased at a pharmacy without a prescription from your doctor. The dosage for each patient is prescribed by the treating neurologist. You should not self-medicate or use medications uncontrollably.

For more information about the drug Mexidol, watch this video:

Thus, Mexidol is a drug aimed at treating diseases and injuries associated with. Effective therapy is based on taking the prescribed doses for the patient based on the medical history and tests performed throughout the disease.

The cardiovascular system often fails, especially due to age-related changes in organism. Weakness, drowsiness appears, autonomic disorders or even atherosclerosis and heart failure. All these conditions are successfully relieved by the drug Mexidol. The question of when to inject Mexidol in the morning or evening worries many

Brief description of the drug

Mexidol is prescribed by a neurologist or cardiologist for the treatment of diseases of the brain, heart and nervous system. It helps perfectly both with mild vegetative-vascular disorders and with serious pathologies:

• asthenic syndrome against the background of alcohol dependence;
• acute cerebrovascular accident;
• coronary disease hearts;
• stroke and heart attack;
• severe intoxication with neuroleptics;
• neurosis-like and psychosomatic disorders;
• oxygen starvation of tissues of various etiologies (hypoxia).

It is actively used during the recovery period after traumatic brain injuries and purulent inflammation of the abdominal organs. Approved for use by almost everyone except children (under 12 years old) and pregnant women. It is well tolerated, with the rare exception of individual intolerance to the components.

Mexidol is available in tablets and injections, which allows you to use different ways– orally, intramuscularly, intravenously. In this case, it can be administered in a stream or drip, depending on the severity of the condition. Doctors are inclined to believe that it is better to inject Mexidol for a more systemic and rapid effect.

When is the best time to inject Mexidol?

Injection form The drug is available in the form of a concentrated solution in ampoules. 1 ml of medicine contains 50 mg of the active substance (ethylmethylhydroxypyridine succinate). There are no universal instructions for use. In every single clinical case An individual treatment regimen and course duration are selected:

• for mild autonomic disorders, an injection of Mexidol is given intramuscularly at a dosage of 50-100 mg per day for 2-4 weeks;
• severe conditions associated with cerebral circulatory dysfunction require drip or jet administration of the drug in an amount of 200-500 mg 2-4 times a day

Most experts agree that Mexidol should be injected in the morning, that is, in the first half of the day. There is good reason for this recommendation. The drug has a tonic effect, it invigorates and activates the cardiovascular system. If you inject before bedtime, it will be difficult to fall asleep. Therefore, when one-time use It is advisable to give the injection in the morning. If the treatment regimen involves dividing it into several doses, then the evening procedure should be carried out several hours before bedtime.

Mexidol is used exclusively as prescribed by a doctor, so the nuances of the timing of the injection are discussed individually.

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pillsman.org

Mexidol tablets: instructions for use

Mexidol is an antioxidant drug that realizes its effects through the inhibition of free radical processes. It also has membrane protective properties and can have nootropic, mild anticonvulsant, vasoactive and anxiolytic effects.

Available in the form of biconvex round tablets of white or cream color. The active ingredient of Mexidol tablets isate, content 125 mg in 1 tablet. The substance was first synthesized in the 1980s at the State Research Institute of Pharmacology of the Russian Academy of Medical Sciences. Included in many standards for the provision of medical care in the Russian Federation. In addition to the active ingredient, the tablets contain Excipients: macrogol, polyvinyl alcohol, talc and titanium compounds. Also available in injections for intramuscular or intravenous injections.

The drug can increase resistance to damaging influences (hypoxia, ischemia, shock, cerebral circulatory disorders, intoxication alcoholic drinks or antipsychotics). The drug blocks lipid peroxidation, which can cause cell damage. The activity of membrane enzymes and receptor complexes is also modulated, which improves the functioning of brain cell membranes. Taking Mexidol improves the functioning of synapses, enhances the mechanism of compensatory glycolysis and reduces the inhibition of oxidative processes in the Krebs cycle under conditions of low oxygen content in cells.

Mexidol is able to reduce platelet aggregation, thereby improving rheological properties blood. Stabilizes blood cell membranes during hemolytic processes. Has a mild lipid-lowering effect.

In addition to the effects described above, Mexidol is able to stabilize disturbed vegetative processes, restore sleep, improve memory, and reduce morphological and dystrophic disorders in brain structures. It has a good antitoxic effect during alcohol abuse, including during abstinence. Reduces symptoms of acute alcohol intoxication, normalizes behavior, relieves cognitive impairment due to chronic alcohol consumption. Mexidol can enhance the effect of tranquilizers, antidepressants, antipsychotics, hypnotics and anticonvulsants, which, when joint reception, can help reduce drug dosages and reduce possible side effects.

Pharmacokinetically, Mexidol tablets are well absorbed when taken orally. It is quickly distributed throughout organs and tissues, the average duration of action of Mexidol is about 4-5 hours. Metabolized in the liver into 5 metabolites, pharmacologically active metabolites are determined in the urine for up to 48 hours.

The half-life after oral administration is 2.5 hours. It is excreted in the urine, mainly in the form of metabolites, and also, slightly, unchanged. The most intense elimination is observed in the first 4 hours after administration.

Indications

Mexidol tablets are used very widely in neurological practice, in particular for the following conditions:

• ACVA (hemorrhagic and ischemic stroke), as well as their consequences.
• TBI (concussion).
• Encephalopathy.
• Encephalopathy of combined origin.
• Anxiety disorders.
• Abstinence.
• Poisoning with antipsychotics.
• Asthenia.
• Weakness and dizziness as part of asthenia.
• Dizziness of various origins (with vascular diseases brain).

Contraindications

There are a number of contraindications to the use of the drug:

• Acute renal failure.
• Allergic reactions to the drug.
• Pediatric practice.
• Pregnancy and lactation.

It is also undesirable to use Mexidol when significant violations liver functions.

Mode of application

Mexidol tablets are taken orally, regardless of meals. Doses are 1-2 tablets (125-250 mg) three times a day. Maximum dosage 6 tablets (or 0.8 grams). The course of treatment is 1-2 months. Repeated courses are possible 2-3 times a year.

At alcohol withdrawal and antipsychotic poisoning, the course of treatment can be 7-10 days.

Side effects

Side effects when taking Mexidol tablets are quite rare. Sometimes there is individual poor tolerance in the form of nausea and other dyspeptic complaints. Also, as with any drug, hypersensitivity reactions are possible with Mexidol.

Overdose

Mexidol tablets are safe to use; cases of overdose are extremely rare. In case of overdose, general weakness or drowsiness may develop.

special instructions

When taking Mexidol tablets, you should remember special instructions:

• When used with antidepressants, benzodiazepines, anxiolytics, anticonvulsants, an increase in their effects should be expected. The toxic effect of ethanol, when used together, is reduced.
• When taking Mexidol, you should be careful when driving a car or performing potentially dangerous work that requires quick reaction and attention.

Storage conditions

Mexidol tablets should be stored in a dark, dry place at temperatures no higher than 24-25 degrees Celsius. The storage period should not exceed 3 years.

Analogs

Mexidol tablets are an original medicine. Generic drugs, the active ingredient of which is alsoate, are such drugs as Neurox, Mexifin, Mexiprim, Armadin, Mexidant, Mexicor, Cerecard, Metostabil, as well as some other drugs that are not widely used on the market.

Price

Mexidol tablets are dispensed from pharmacies with a doctor’s prescription. Found in almost all pharmacies. Average prices vary within wide limits due to various factors and are:

• Pack of 30 tablets 233-290 rubles.
• Pack of 50 tablets 350-475 rubles.

Do not self-medicate to avoid tragic consequences. Before using Mexidol tablets, consult your doctor!

Video commentary by the author

vertigonet.ru

Mexidol tablets and injections: instructions for use, analogues

Mexidol - popular medicinal product, which was developed in 1996 by Russian scientists. Refers to a new generation of antioxidants, used to improve cerebral circulation. It is part of a group of nootropic drugs, the action of which is aimed at normalizing metabolic processes in brain cells and protecting them from free radicals. This allows Mexidol to be widely used in neurological practice.

Its use is not limited to one area of ​​medicine; the drug is used to treat various pathologies in psychiatry, surgery and narcology. Unique properties antioxidants allow not only to restore memory, speech and skills lost as a result of a stroke or ischemic brain damage, but also increase the body’s resistance to various intoxications and stressful situations. In addition, Mexidol, as part of complex therapy, helps to stop acute purulent-inflammatory processes in the abdominal cavity. Let us dwell in more detail on the therapeutic effect of this drug, methods of its use and tell you what it helps with.

Mexidol - the effect of the drug

Mexidol is an antioxidant agent with nootropic, antihypoxic, anticonvulsant and antistress effects. The main active ingredient is ethylmethylhydroxypyridine succinate. The main objective of the drug is to increase the body's resistance to the action of various damaging factors (hypoxia, cerebrovascular accident, ischemia, intoxication).

Mexidol helps improve blood microcirculation, better blood supply to the brain and restore metabolism in nerve cells. Under its action, the structure of cell membranes is stabilized, platelet aggregation is reduced, and cholesterol levels in the blood are reduced.

The nootropic effect of the drug is expressed in the activation of mental activity, increasing the ability to learn and assimilate information, and improving memory. As an antioxidant, the drug protects body cells from excessive oxidation, reduces the harmful effects of free radicals, slows down aging and increases the resistance of organs and tissues to oxygen starvation.

The use of Mexidol helps restore the disrupted sleep-wake cycle and reduce the rate of development of degenerative processes. When using the drug, the production of the “joy hormone” - dopamine - increases, which makes Mexidol an excellent treatment depressive states.

This hormone helps get rid of anxiety states, suppresses anxiety and fear, helps with sleep disorders, neurological and autonomic disorders. The drug has anti-stress, anticonvulsant and antihypoxic effects, promoting oxygen saturation in the blood.

The drug helps to weaken the toxic effect of alcohol, relieves acute withdrawal syndrome, restores behavioral disorders, and has an anticonvulsant effect. Concomitant use Mexidol with tranquilizers, antidepressants, sleeping pills, antipsychotics enhances their effect, which allows you to reduce the doses of these drugs and reduce adverse reactions.

When taken orally, Mexidol is quickly absorbed and distributed in organs and tissues. The drug is excreted from the body in the urine in the form of metabolites; a small amount of the drug is excreted unchanged. The greatest intensity of excretion is observed within 4 hours after taking a dose of the drug.

Composition and release form

Photo: Medicine Mexidol in the form oral tablets

Mexidol is produced in two dosage forms:

• Medicine Mexidol in the form of oral tablets
• Mexidol in ampoules for IV and intramuscular administration

Mexidol tablets are biconvex, coated with a white or slightly cream color. In a cross section, two layers are visible: the gray core and the white outer shell. One tablet contains 125 mg of active ingredient. The drug is packaged in contour cell blisters of 10 tablets each (3-5 blisters per package) or plastic jars containing 90 tablets. For hospitals, the drug is sold in plastic containers containing 450 or 900 tablets.

The drug solution is produced in ampoules made of colorless or dark glass, with a white break point, which are packaged in 5 or 10 pieces in contour cellular blisters. One or two blisters are placed in a cardboard package with the drug. Mexidol ampoules have a volume of 2 and 5 ml. This form of the drug is a clear, colorless or slightly yellowish solution intended for infusion or intramuscular injection. 1 ml of solution contains 50 mg of active substance.

Mexidol is stored in a dry place, protected from light. Storage temperature should not exceed 25°C; all forms of the drug are suitable for use for 3 years.

When is Mexidol prescribed - indications

IN medical practice The list of diseases for which Mexidol is used is quite extensive. It is primarily used in neurology to treat the following conditions:

• Prevention and treatment of strokes in the acute and recovery period
• Manifestations of vegetative-vascular dystonia
• Progressive cerebrovascular insufficiency (encephalopathy)
• Mild traumatic brain injury and its consequences
• Cognitive disorders resulting from atherosclerosis (impaired intelligence, memory, speech)
• Ischemic disease
• Asthenic syndrome

In psychiatry:

• Prevention of somatic neuroses
• Neurotic disorders: anxiety, sleep disturbances
• For symptoms of antipsychotic poisoning
• Under extreme stress factors

In narcology:

• Relieving withdrawal symptoms
• Relieving alcohol withdrawal, manifested in vegetative-vascular and neurotic symptoms

In surgery:

• As part of a comprehensive therapeutic treatment for acute purulent-inflammatory pathologies of the peritoneum (peritonitis, necrotizing pancreatitis).

Experts consider the most appropriate use of Mexidol for sclerosis and encephalopathies of various etiologies, vegetative-vascular dystonia, convulsive conditions, epilepsy, neuroses, phobias and traumatic brain injuries.

Instructions for use (tablets, solution for injections)

Photo: Instructions for use (tablets, solution for injections)

According to the instructions for use of Mexidol, the drug, when taken orally, is prescribed 1-2 tablets three times a day. At the beginning of treatment, the recommended dose is taken once or twice a day, then the frequency of administration is increased to achieve the desired effect. The maximum daily dose should not exceed 800 mg (6 tablets). The duration of treatment is from 2 to 6 weeks; to relieve withdrawal symptoms, it is enough to take the drug for 7 days.

Treatment cannot be abruptly interrupted; the dose should be gradually reduced over 3 days until the drug is completely discontinued. The optimal treatment regimen is selected by the doctor, taking into account individual characteristics patient, general condition and severity of symptoms. For ischemic disease, the course of treatment is longer - up to 8 weeks; if necessary, the doctor can prescribe a second course of therapy after a break. The most optimal period for a second course of treatment is spring and autumn.

Mexidol solution can be administered intravenously and intramuscularly. Before infusion administration using a dropper, the drug should be diluted in an isotonic sodium chloride solution. The rate of drip infusion should not exceed 40-60 drops per minute. The recommended volume of the drug is 100-150 ml. The jet injection must be carried out very slowly, over 5-6 minutes.

For treatment acute disorders cerebral circulation, the drug should be infused according to a certain scheme. In the first 10-14 days, a volume of 200-500 mg is given intravenously by drip 2 to 4 times a day. In the next 2 weeks, intramuscular injections are carried out, administering 200-250 mg of the drug 2-3 times a day.

To eliminate the consequences of traumatic brain injury, the drug is administered by drip in a volume of 200-500 mg from 2 to 4 times a day, depending on the patient’s condition. The course of therapy is 10-15 days.

For slowly progressing circulatory failure, the dose is selected individually by the attending physician. The drug is administered intravenously or by bolus once a day for 2 weeks. Further treatment is carried out using intramuscular injections.

For anxiety disorders and cognitive impairment in the elderly, the drug is administered intramuscularly in a daily dose of 100 to 300 mg. Treatment is carried out for 2-4 weeks.

To eliminate alcohol withdrawal, the medicine is infused intramuscularly or using a dropper. Perform 2-3 procedures per day, administering the drug in a volume of 200 to 500 mg.

For purulent abscesses of the abdominal cavity, Mexidol can be administered intravenously or intramuscularly a day before surgical intervention, or on the first day after surgery. The dose is selected individually, it depends on the severity of the disease, the degree of damage and the general condition of the patient.

Contraindications

Contraindications to the use of the drug are:

• Individual intolerance to the components of the drug
• Pregnancy and period breastfeeding
• Childhood
• Acute dysfunction of the liver and kidneys

Since the effect of the drug has not been sufficiently studied, it is not used to treat children, pregnant and lactating women. Take special care when using Mexidol in patients with hypertension, low blood pressure, arterial hypertension accompanied by crises.

The instructions for the drug say that it is not prescribed in childhood, but in pediatrics it is still used in the treatment of traumatic brain injuries and purulent neuroinfections. As an emergency aid for injuries, a single use of Mexidol at a dose of 100 mg is indicated. In other cases, the dose of the drug is selected individually by the pediatrician and depends on the child’s condition, severity pathological process and general clinical picture. The treatment is carried out under the supervision of a specialist.

Side effects

Side effects

Side effects from the use of the drug are insignificant. Mexidol is characterized by low toxicity and does not have a negative effect on blood composition, respiratory rhythm, or heart rate. IN in rare cases Undesirable reactions from the gastrointestinal tract may occur. After taking the pills, symptoms of a dyspeptic nature are noted, which manifest themselves as discomfort and painful sensations in the abdomen.

Patients complain of nausea, heartburn, a feeling of fullness and heaviness in the abdomen. This condition may be accompanied by the development of diarrhea. In some cases, individual reactions are expressed in appetite disturbance, flatulence, a feeling of weakness, and lethargy. With increased sensitivity to the components of the drug, allergic reactions occur.

When treated with Mexidol solution, patients may experience bouts of nausea, increased dryness in the mouth, weakness and drowsiness. In rare cases, allergic reactions develop.

Taking the drug in high doses can provoke surges in blood pressure, increased emotional excitability, symptoms of hyperhidrosis, and impaired coordination of movements. In case of overdose, gastric lavage and other methods of symptomatic therapy are used.

Drug interactions with other drugs

Mexidol has good compatibility with all drugs used to treat somatic diseases. Simultaneous use with neuroleptics, antidepressants, tranquilizers and anticonvulsants enhances them therapeutic effect, which allows you to reduce the dose of these drugs and avoid the development of unwanted side reactions of the body.

Mexidol reduces the toxic effect of ethanol and promotes the removal of alcohol from the body. This feature of the drug is used to eliminate withdrawal symptoms in the treatment of alcohol addiction.

special instructions

The use of Mexidol in patients with bronchial asthma suffering from hypersensitivity to sulfites can cause the development of severe allergic reactions.

The drug can slow down the speed of reactions and reduce concentration, so it should be used with extreme caution when driving a vehicle or performing work involving dangerous mechanisms and requiring rapid psychomotor reactions.

Analogs

Mexidol has a number of analogues that are similar in composition and pharmacological action:

• Mexidant
• Mexiprim
• Mexicor
• Neurox
• Cerecard
• Combilipen
• Hypoxene

Many patients during treatment are interested in whether it is possible to replace Mexidol with cheaper analogues? Despite the fact that the drug is not cheap, it has established itself in the domestic market as the most effective and successful product. Many of its analogues, which have a similar therapeutic effect, differ only in the composition of the excipients and, according to the doctor’s decision, can be used as part of combination therapy together with Mexidol.

But it is not recommended to independently replace the medicine with analogues, since many of them have undesirable side effects or may have insufficient therapeutic effect. The decision to replace must be made by a specialist who will take into account possible contraindications and select the right dosage.

Price

Average prices for the drug in the pharmacy chain:

• Mexidol tablets (30 pieces) – 220-280 rubles
• Mexidol tablets (50 pieces) – 350-380 rubles
• Mexidol solution (5 ampoules) – 350-470 rubles
• Mexidol solution (10 ampoules) – 380-500 rubles.

Reviews about the application

Review #1

Vegeto - vascular dystonia– a very unpleasant companion who has been accompanying me for the last few years. It becomes especially unpleasant when the seasons change: incessant headaches, dizziness and drowsiness. I had to seek help from a local clinic. The doctor advised Mexidol intramuscularly.

I read the instructions for use and realized that it suits me. To be honest, I did not expect any stunning effect from the drug. However, Mexidol not only met all my expectations, but also became a savior for me. The injections themselves turned out to be painless, and after ten such procedures I felt like a human being.

The most real person who leads active life and does not constantly suffer from dizziness, migraines and loss of energy. Plus, my concentration has improved, I can now do anything and not fall asleep on the go or lie on the bed suffering from a headache. None side effects I didn’t find it during treatment. The course of treatment has ended healing effect still holding up. If in the future old problems make themselves felt, now I know what will help me out.

Galina, Novosibirsk

Review #2

I didn't take it myself this drug, but I had a chance to see it in action with my own eyes. Grandfather had a mini-stroke, his leg was partially paralyzed, he dragged it a lot when walking, speech was difficult. The attending physician prescribed Mexidol as one of the elements of complex treatment. As a result, after taking this drug, my grandfather began to feel better.

Over time, speech returned to normal, memory returned, and you can communicate with him as before. Today, no signs of the attack are visible. Grandfather talks, walks independently, leads a normal lifestyle. Everything returned to normal, and I am sure that Mexidol contributed to this.

Nastya, St. Petersburg

Review #3

My work involves mental activity. I have to spend almost the whole day at the computer. I began to suffer from severe headaches. The attacks were so strong that nausea set in. I went to the clinic. We carried out an examination, the doctor said that the headaches were caused by increased intracranial pressure and deterioration of cerebral circulation.

That is why I started having these attacks. The doctor prescribed Mexidol. I was afraid that the price would be too high, but for this effective drug it turned out to be quite acceptable. I bought a pack of tablets (50 pieces) and started taking them. Within a week after starting treatment, the headache began to hurt less. And the work became easier, my concentration improved.

True, I felt discomfort in my stomach for some time, and dry mouth appeared, but these phenomena soon passed. After a month of taking the drug, I completely forgot about headaches. I even slept better. Two months have passed since the course of treatment, and so far everything is good: my head doesn’t hurt, I feel much better.

Olga, Moscow

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Instructions for use of the drug "Mexidol"

Mexidol comes with instructions for use, which allow you to understand all the properties of the drug, recommendations for use, and contraindications. The medication is sold in pharmacies only with a doctor's prescription, complete with official instructions from the manufacturer.

Composition of the drug and its pharmacological properties

The 1st ampoule of solution contains 50 mg of ethylmethylhydroxypyridine succinite. Auxiliary components: sodium metabisulfite, saline solution, magnesium stearate, sodium carmellose, lactose monohydrate, polyvinyl alcohol, talc, titanium dioxide. "Mexidol" tablets contain 125 mg of active substance.

The drug belongs to the group of nootropics and has a positive effect on all mental processes in the human body. Under the influence of the drug, many pathological changes stop their development. Thanks to the action of the medicine, a person sleeps better.

All this is achieved due to the fact that active ingredient as part of the drug is able to restore the functionality of cell membranes and remove free radicals from the body. Taking the drug helps saturate the blood with oxygen, relieves stress, and has anticonvulsant and antioxidant effects. Thanks to improved circulation in circulatory system Cholesterol levels are reduced, the physiological qualities of plasma (viscosity, flow rate, etc.) are improved. In cellular mitochondria, the drug promotes the active formation of energy, and in nerve cells the transmission of synoptic impulses is significantly accelerated.

It is recommended to take Mexidol in combination with tranquilizers, antidepressants, antipsychotics, sleeping pills and anticonvulsants. The active substance in the medicine only enhances the effect of the above medications. This combination allows you to reduce the dose, which eliminates many side effects.

Mexidol is widely used in dentistry.

Treatment with Mexidol during pregnancy is not recommended, since there is no reliable data on clinical studies on patients taking this drug during pregnancy.

The drug is often used in complex therapy of children with traumatic brain injuries and purulent neuroinfections. A single dosage is prescribed only by the attending physician. The child is closely monitored while taking the medicine.

In what situations is it used and possible contraindications?

The use of the drug "Mexidol" is indicated for the following diseases:

• vegetative-vascular dystonia;
• disturbances of speech function, intellectual activity, memory and attention;
• vascular diseases in brain tissue;
• withdrawal syndrome that occurs with alcoholism;
• neuroses;
• poisoning with antipsychotic drugs;
• inflammatory processes with purulent formations in the peritoneal organs.

Taking the drug is contraindicated for persons who have been identified as individual intolerant to Mexidol. It is also not recommended to drink Mexidol in case of acute renal and liver failure.

The medicine is practically non-toxic, so the side effects of Mexidol occur very rarely. Regardless of dosage, it does not affect the patient's physical activity level or physiological functions. All reflexes, hemodynamic processes, blood pressure, body temperature remain normal. An overdose may cause nausea and drowsiness. Dry mouth occurs, but quickly goes away on its own. Increased sensitivity to the active substance sometimes causes allergic manifestations in the form of a rash on the skin.

Due to the drug’s ability to quickly remove toxins and free radicals from the body, it is used to relieve painful symptoms with alcohol intoxication.

Types of drug

"Mexidol" tablets. The initial dosage is 1 – 2 tablets 2 times a day, after which the frequency of administration is increased to 3 times a day. Treatment therapy lasts on average 2–6 weeks, depending on the severity of the disease and the general condition of the patient. The dosage is gradually reduced, approaching the completion of the therapeutic course of treatment. So, people suffering alcohol addiction, drank Mexidol for 7 days.

Rinsing and applying applications. IN dental practice Mexidol injection solutions are successfully used to rinse the mouth and rinse periodontal pockets. Local applications with the solution have a good effect. Procedures must be performed regularly, at least 3 times a day. Treatment takes as long as necessary to achieve positive dynamics in the development of the pathology.

Injection. The 5% solution is produced in ampoules of 2 ml. It can be used for intravenous, intramuscular injections, droppers. Saline solution is used as a solvent.

The dose is strictly individually selected by the attending physician depending on the purpose, disease and severity of its course. Treatment is started with the minimum dose, then increased to the maximum allowable. Up to 0.8 g of the drug can be administered per day.

Treatment of dementia in older patients is carried out using intramuscular injections. The drug, administered intravenously, is good for acute intoxication of the body, inflammatory diseases peritoneal organs.

The drug "Mexidol" is well absorbed and quickly eliminated from the body. It undergoes breakdown in the liver within 5 hours after the first dose, then is completely excreted in the urine.

"Mexidol" in dentistry

Due to the property of Mexidol to have anti-inflammatory and antioxidant effects, it is widely used in dentistry as a therapeutic and prophylactic for stomatitis, gingivitis, caries. It is added to toothpaste, which fights periodontitis, stops bleeding gums, reduces their sensitivity, eliminates pathogenic bacteria, and significantly increases immunity in the oral cavity. After regular use of Mexidol Dent toothpaste, patients note healing of wounds, restoration of the oral mucosa, and the disappearance of unpleasant odor.

It is recommended to brush your teeth with Mexidol Dent 3 times a day or after meals. If the sensitivity of the gums is excessively high, then doctors prescribe Mexidol Dent Sensitive. The paste contains potassium nitrate. This substance allows you to block nerve endings, which reduces general sensitivity teeth, which occurs in many diseases. With regular use of the paste, many painful symptoms go away.

Toothpaste has an effective whitening effect and quickly relieves inflammation. Plaque is removed with papain. It contains calcium citrate and hydroxyapatite. These substances penetrate deep into the enamel of the teeth after the plaque from their surface is completely removed. For a long period of time, teeth remain fresh, clean and White color.

The effect of Mexidol in the treatment of other diseases

For the drug to be effective, it is necessary to adhere to a strictly defined treatment regimen:

1. If blood circulation in the brain tissue is impaired, the drug is administered via a dropper for 2 weeks. The maximum permissible dose per day is 500 mg. Then they begin to gradually reduce the dosage of the drug, bringing it to 250 mg per day.
2. Encephalopathy in the acute phase. The medicine is administered intravenously 2 times a day for 2 weeks. The dosage ranges from 250 to 500 ml of Mexidol. After this, over the next 2 weeks, reduce the administration of the drug to half the original dosage.
3. Mild impairments mental processes central nervous system in older patients is treated with intramuscular injections. The course of therapy ranges from 2 weeks to 30 days. 100–300 ml of the drug is administered. The medication is also used to prevent many mental illness.
4. To eliminate alcohol withdrawal syndrome or withdrawal, the doctor prescribes up to 250 mg of Mexidol, administered intravenously or intramuscularly. The duration of treatment is 5 – 6 days.
5. Neuroleptic poisoning occurs from uncontrolled use of the drug. Painful symptoms are quickly relieved with intravenous injections with a maximum dose of 500 mg.
6. Whenever purulent infections peritoneum, as well as inflammatory processes of its organs, Mexidol is used from the first hours after surgery. The doctor calculates the dosage of the drug depending on the severity of the disease, form and individual characteristics. As soon as the therapeutic effect is achieved, the drug begins to be gradually withdrawn.
7. Acute pancreatitis accompanied by swelling. A maximum dosage of up to 500 mg per day 3 times a day is allowed. The medication is administered using a dropper or intramuscularly.
8. Moderate purulent pancreatitis. Treat only with a dropper using 200 mg of the drug. The course of treatment lasts from 2 to 4 weeks. Droppers must be placed 3 times a day.
9. Necrotizing pancreatitis. Treatment is prescribed using large dose(up to 500 mg per day). The medicine is administered intravenously for 2 weeks. After this, they begin to gradually reduce the dosage.

Necrotizing pancreatitis is extremely severe. It is necessary to take up to 800 mg of medication per day or until the painful symptoms and shock completely disappear. After the patient's condition becomes stable, the dosage is gradually reduced. The medication is administered only after meals.

Analogs

Mexidol appeared on the domestic market relatively recently, but has already established itself due to its effectiveness and speed of action. However, its clinical studies have not yet been fully completed and continue to this day. If a drug does not give a good result over a certain period of time, then it is necessary to replace it with a drug of a similar composition and effect. The choice is made only by the doctor, based on the individual characteristics of the patient, the type of disease and its severity.

"Mexiprim" is an analogue of the Russian "Mexidol", produced in Germany. Mexiprim and Mexidol have the same active ingredient. The only difference is in the composition of the excipients. If you compare which is better - Mexidol or Mexiprim, then it is advisable to leave the choice to your doctor. Before you start using Mexiprim, you must carefully study the instructions for use.

In addition to Mexiprim, the medicine has many other analogues: Cavinton, Mildronate, Neurox, Cortexin, Nootropil and others.

As for Cavinton, it is not advisable to take it simultaneously with Mexidol. When used separately, both medicines and give excellent results in therapeutic therapy. "Cavinton" gives a positive effect when trying to restore cerebral circulation, improve blood pressure, and restore the supply of oxygen to brain tissue. This drug is often used to treat ophthalmological diseases and ENT organs.

"Neurox" is a complete analogue of "Mexidol", since it contains the same active component.

"Mildronat" is an effective vasodilator. With its help, you can quickly and effectively restore the supply of oxygen to brain tissue and improve blood supply. The medicine is often taken when complex treatment ischemic disease. It lowers high blood pressure, has an effective effect on humoral and cellular immunity.

"Cortexin" is a drug created on the basis of an extract from the brain of cattle. It has a particularly powerful effect in the treatment of newborn patients with hypoxia of brain tissue.

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How to take Mexidol before or after meals is a question that worries patients in the first place. In order to avoid side effects, you must follow the instructions for use.

Abstract to the medicine

The instructions for the drug do not contain information about the compatibility of the active ingredients of the drug with food. In this regard, Mexidol can be taken regardless of the food included in the composition. daily menu. In addition, among the advantages of the drug, the following characteristics can be distinguished:

• no nausea after administration;
• well tolerated by patients;
• antioxidant effect on the body.

Indications for use

This medication can be recommended for use by specialists in various medical fields. As a rule, Mexidol should be taken if you have the following health problems:

• various consequences of brain accidents;
• head injuries;
• diseases associated with impaired vascular function;
• ischemia;
• neurological diseases;
• weakness, lethargy and general malaise.

In each case, a specialist, taking into account all the characteristics of the patient’s body, develops a course of treatment with which the most effective effect can be achieved. In addition, the doctor will advise how and at what time to take the tablets correctly - before or after meals.

Contraindications

Despite wide range effects, Mexidol cannot be taken by all patients. There are cases in which the use of the medication will not be beneficial and will not help cope with the disease:

• individual intolerance to components;
• pregnancy;
• lactation period;
• acute liver and kidney failure.

Application options and daily dose

The drug is available in 2 forms:

The dose of the drug, which is recommended for use during the day, is calculated individually in each case. It all depends on the patient’s age, the nature and stage of development of the disease. On average, a patient is recommended to take a dose of medication per day.

It is known that taking many medications on an empty stomach has a negative effect on the stomach and digestive system as a whole. To avoid this problem, Mexidol tablets should be taken after meals.

Similar drugs

There are a sufficient number of drugs whose composition is similar to Mexidol. Among its main substitutes are:

The drugs are produced in tablets or ampoules intended for injection.

In addition to the similarity in composition, there are medications that resemble Mexidol in the nature of their effect on the body:

How to take Mexidol tablets

The popular new generation drug Mexidol, which belongs to the group of new generation antioxidants, is designed to stop destructive processes in the human body. Therefore, you need to know how to take Mexidol tablets to restore and normalize metabolic processes in brain cells, so as not to harm the body.

Composition of the drug and scope of application

The active ingredient in Mexidol is ethylmethylhydroxypyridine succinate 125 mg, resulting in the following type of effect on the body:

• Hypoxia tolerance improves;
• Mental abilities and concentration improve;
• Easier to tolerate by the body stressful situations of various nature;
• The state of nervousness is relieved;
• The toxic effects of alcohol on the body are reduced;
• Blood circulation in the brain improves;
• Sleep, appetite and general condition of the body improves.

Mexidol tablets, according to the instructions attached to the drug, are indicated for use to prevent cell oxidation and stabilize the structure of intracellular membranes. Regular use of this drug prevents platelet aggregation, reduces cholesterol levels in the blood and prevents the development of degenerative processes, thereby slowing down the aging process of the body.

Release form

Mexidol is available on pharmaceutical market in 2 dosage forms: tablets and ampoules.

For oral administration, the tablet form of this drug is used, biconvex in shape, in a white or cream-colored shell. Which are packaged in 10 pieces, in cell blisters.

To administer Mexidol intramuscularly or by infusion, the medicine is released in ampoules made of white or darkened glass. The solution contained in an ampoule with a volume of 2–5 ml is colorless or slightly colored yellow liquid, odorless and contains 50 mg of ethylmethylhydroxypyridine succinate per 1 ml of solution. The drug is injected intramuscularly into the upper outer quadrant of the gluteal muscle.

Mexidol is stored in a dry, dark place, indoors with a maximum temperature increase of up to 25 ° C. If unpacked, Mexidol is stored for up to 3 years from the date of production indicated on the package.

Taking Mexidol and its dosage

Mexidol tablets should be taken one or two tablets 3 times a day, taking into account individual tolerance of the drug, but not exceeding maximum dose 600 mg, most often the course of treatment with Mexidol involves taking the medication for 14 to 42 days. With a gradual exit from it, which involves a daily reduction in the daily dose of the drug.

Use of Mexidol for VSD

At vegetative-vascular dystonia The drug in tablets is taken at a dose of 125–250 mg, up to 3 times a day, or according to a regimen drawn up by the attending physician, which takes into account the individual characteristics of the patient and allows to minimize side effects from the use of the drug.

If after taking the medicine the patient feels lethargic or persistent drowsiness, it is necessary to contact the attending physician to review the dosage of the medicine. To avoid negative consequences for the body, stopping taking the pills on your own is not recommended.

After taking Mexilod, during the treatment of VSD, the patient experienced significant improvement psychological state, aggressiveness disappears, the feeling of depression and oppression goes away, recovery from a depressive state is accelerated.

Relieving alcohol withdrawal

To relieve alcohol withdrawal syndrome, it is better to take Mexidol tablets for 7 days, as a continuation of treatment, after the course intramuscular injections. The doctor independently, based on the individual characteristics of the patient’s body, selects the dosage of the drug for the patient and prescribes a regimen for taking the pills. The medicine entering the patient’s body quickly relieves withdrawal symptoms, restores the psycho-emotional background, improves memory and promotes rapid cleansing of the body when ingesting ethanol.

Cerebral circulatory disorders

In case of circulatory disorders in the brain, an intravenous course of the drug is prescribed, which is administered for 10-14 days 2-4 times a day, in a volume not exceeding 500 mg, by drip method. After which, for 2 weeks the medicine is administered by intramuscular injection, 2-3 times a day, 200-250 mg of the drug.

Upon completion of the main stage of therapeutic treatment, the patient may be prescribed oral administration of the drug at for preventive purposes. To find out how to drink Mexidol, you need to consult your doctor.

Medicines with a similar spectrum of action

Mexidol is an original medicinal product with a patented active ingredient; its analogues on the pharmaceutical market are:

And other not so widespread medications. Despite the fact that the medicine is not cheap, in order to avoid unwanted side effects, it is not recommended to independently replace it with analogue drugs that have similar therapeutic characteristics.

Side effect of Mexidol, with uncontrolled use

Uncontrolled oral intake of Mexidol can provoke the following undesirable sensations: heartburn, nausea, headache, belching, general physical weakness, upset stomach. In extremely rare cases, Mexidol can provoke a decrease in blood pressure, impaired motor coordination and emotional hyperreactivity.

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Mexidol ® tablets

PRESCRIPTION MEDICINES ARE PRESCRIBED TO THE PATIENT ONLY BY A DOCTOR. THIS INSTRUCTION IS FOR MEDICAL PROFESSIONALS ONLY.

INSTRUCTIONS for medical use of the drug Mexidol ®

Registration number: LSR/07 dated 08/09/2007

Trade name of the drug: Mexidol

Chemical rational name: 2-ethyl-6-methyl-3-hydroxypyridine succinate.

Dosage form: film-coated tablets

Active substance: ethylmethylhydroxypyridine succinate mg, excipients: lactose monohydrate, sodium carboxymethylcellulose (carmellose sodium), magnesium stearate, shell: opadry II white (macrogol (polyethylene glycol), polyvinyl alcohol, talc, titanium dioxide).

Description: Tablets are round, biconvex, film-coated, from white to white with a creamy tint.

Pharmacotherapeutic group: antioxidant agent.

Pharmacological properties:

Mexidol is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics (neuroleptics)). The mechanism of action of Mexidol is due to its antioxidant, antihypoxic and membrane protective effects. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, neurotransmitter transport and improve synaptic transmission. Mexidol increases the content of dopamine in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes. The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. Has a hypolipidemic effect, reduces the content total cholesterol and low density lipoproteins. The anti-stress effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, reduction of dystrophic and morphological changes in various structures of the brain. Mexidol has a pronounced antitoxic effect in withdrawal syndrome. It eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairment caused by long-term use of ethanol and its withdrawal. Under the influence of Mexidol, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Rapidly absorbed when taken orally. The maximum concentration at mg doses is 3.5 - 4.0 mcg/ml. Quickly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9 - 5.2 hours. Metabolized in the liver by glucuron conjugation. 5 metabolites have been identified: 3-hydroxypyridine phosphate - formed in the liver and, with the participation of alkaline phosphatase, breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, formed in large quantities and is found in urine immediately after administration; 3rd - excreted in large quantities in the urine; 4th and 5th - glucuron conjugates. Tx/2 when taken orally - 2.0 - 2.6 hours. It is quickly excreted in the urine, mainly in the form of metabolites and in small quantities - unchanged. The most intensive elimination occurs during the first 4 hours after taking the drug. Rates of urinary excretion of unchanged drug and metabolites have individual variability.

Indications for use:

Consequences of acute cerebrovascular accidents, including after transient ischemic attacks, in the subcompensation phase as preventive courses;

Mild traumatic brain injury, consequences of traumatic brain injury;

Encephalopathies of various origins (dyscirculatory, ismetabolic, post-traumatic, mixed);

Autonomic dystonia syndrome;

Mild cognitive disorders of atherosclerotic origin;

Anxiety disorders in neurotic and neurosis-like conditions;

Relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-withdrawal disorders;

Conditions after acute intoxication with antipsychotic drugs;

Asthenic conditions, as well as for the prevention of the development of somatic diseases under the influence of extreme factors and stress;

Impact of extreme (stress) factors.

Contraindications:

Acute liver and/or renal failure, increased individual sensitivity to the drug. Due to insufficient knowledge of the effect of the drug - childhood, pregnancy, breastfeeding.

Directions for use and dosage:

Orally, mg 3 times a day; maximum daily dose of zamg (6 tablets). Duration of treatment: week; for relief of alcohol withdrawal days. Treatment is stopped gradually, reducing the dose over the course of days. Initial dose 50 mg (1 - 2 tablets) once a day with a gradual increase until therapeutic effect. Maximum daily dose of mg (6 tablets).

Side effect:

Individual adverse reactions may occur: dyspeptic or dyspeptic in nature, allergic reactions.

Interaction with other drugs:

Mexidol is combined with all drugs used to treat somatic diseases. Enhances the effect of benzodiazepine drugs, antidepressants, anxiolytics, anticonvulsants and antiparkinsonian drugs. Reduces the toxic effects of ethyl alcohol.

Special instructions:

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration attention and speed of psychomotor reactions.

Overdose:

In case of overdose, drowsiness may develop.

Release form: Film-coated tablets, 125 mg. 10 tablets in a blister pack made of PVC film and aluminum foil or 90 tablets in a food-grade plastic jar. 1,2,3,5 blister packs of 10 tablets each or 1 plastic jar of 90 tablets each along with instructions for use per pack. For hospital use Film-coated tablets 125 mg. 450 and 900 tablets in a plastic jar made of food grade plastic along with instructions for use in corrugated cardboard boxes.

Storage conditions: List B. Store in a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life: 3 years. Do not use after the expiration date indicated on the pack.

Dispensing conditions: By prescription

A: ZiO-Zdorovye CJSC, Moscow region, Podolsk, st. Zheleznodorozhnaya 2

B: CJSC "ALSI-Pharma", CJSC "ALSI Pharma", Moscow, Trifonovsky deadlock, 3,

Organization receiving claims: LLC NPK Pharmasoft, Moscow, st. Avtozavodskaya, 22

Pharmgroup:

Therapeutic effect:

Reviews and comments

My baby is 8 months old

Anna Fri, 02/08/:49

My child is 8 months old, diagnosed with PPCNSL. The neurologist prescribed Mexidol 1/4 tablet 2 times a day, but the instructions say that Mexidol is contraindicated for children, since no studies have been conducted. Can a child have Mexidol or not?

The doctor may prescribe for the child

A doctor may prescribe a drug to a child if the expected benefit is greater than the risk. Follow the neurologist's prescription. The experience of using Mexidol in children in previous studies showed positive results in the treatment of childhood neurological diseases.

Take Mexidol tablets

Guest Fri, 02/08/:50

Should Mexidol tablets be taken before or after meals, is this not written in the instructions?

Taking Mexidol tablets is not

Taking Mexidol tablets does not depend on food intake.

Hello, I have VSD, and

Inna Fri, 02/08/:01

Hello, I have VSD and acute panic attacks, can I take Mexidol?

Mexidol has been successfully used

Mexidol is successfully used to treat manifestations of vegetative-vascular dystonia, including elements of panic attacks.

For a month I took

Tatyana Fri, 02/08/:16

For a month I took Mexidol tablets, 1 tablet. 3 times a day, after the course I found out that I was pregnant. I am very worried about whether taking this drug will affect the baby and the course of pregnancy.

Don't worry, it won't hurt.

Don't worry, it won't hurt. Mexidol is an antioxidant and contains succinate, which is functionally significant for many processes occurring in the body, in particular, being a substrate for increasing energy metabolism in cells.

My child is 2 years and 9 months old.

Svetlana Fri, 12/12/:18

My child is 2 years and 9 months old. The neurologist prescribed Mexidol, Valfen and Magne B6 for us to take for a month, mix all three drugs 1/3+ 1/3 +3 ml twice a day. This is due to the fact that the child cried in kindergarten, did not eat anything and could not get used to the kindergarten.

Please tell me this will not harm the child.

Such drugs are not

Such drugs are not prescribed simply because a child cries in kindergarten. An accurate diagnosis is needed.

And the child also rose

Svetlana Sat, 13/12/:00

And the child also started vomiting from anxiety, while crying, while eating. For 2 weeks.

After the doctor prescribed these drugs (Mexidol, Valfen and Magne B6), he ordered a fundus test - the result was normal, plus he didn’t prescribe anything else.

Please tell me what to do?

At this time we are not visiting the kindergarten, and everything is fine at home with the child.

If the child is healthy, there is no need

If the child is healthy, there is no need to stuff him with medications.

tell me which one it should be

Vladimir Thu, 02/04/:49

Tell me what the taste of Mexidol should be, I drank one package of tablets, they had no taste, I took another one, it tasted sour

The taste depends on the shell, in

The taste depends on the shell; normally it should not be there.

Likewise! My parents

Natalya Wed, 08/02/:47

Likewise! My parents took Mexidol for many years, but the last time the pills tasted salty! I asked the manufacturer a question and they wrote back that taste doesn’t matter. But still there are vague doubts, what if it’s a fake? How to find out. There are already 4 boxes lying around.

Hello! I was prescribed

Lara Sat, 11/07/:26

Hello! I was prescribed Mexidol, when I went to the pharmacy I read that it contains lactose, and I am allergic to it. To make an appointment with a doctor is a long wait. Tell me what can replace Mexidol.

Medomexi solution for

Medomexi solution for intravenous and intramuscular administration is a lactose-free analogue. Also look at the active ingredient: ethylmethylhydroxypyridine succinate, the list of analogues is at the end of the instructions, and in general, you can ask the pharmacist at the pharmacy about such a replacement

I took Mexidol in

Tatyana Fri, 25/09/:23

I took Mexidol for 1 month from April to May, is it possible to use it after 5.5 months if there are indications for this?

The drug must be prescribed by a doctor

The drug must be prescribed by a doctor during a face-to-face appointment, and he also prescribes the duration of treatment.

Good afternoon. I have

Olga Sat, 26/09/:02

Good afternoon. I'm 19 weeks pregnant and have severe headaches. The neurologist prescribed me Mexidol 1 tablet 3 times, take it for a month. The instructions say it is contraindicated to take during pregnancy. What effects can Mexidol have on a child?

The effect of the drug on the fetus is not

The effect of the drug on the fetus has not been studied, so pregnancy is listed as a contraindication. It's better to be safe than sorry.

My son has low platelets

Irina Sun, 22/11/:04

My son has low platelets, can we take Mexidol?

This is not

This is not a contraindication. Contraindication: children's age.

Application of Maximov for

Valentina. Fri, 05/02/:16

Is there a place to use Maksimov for left-sided facial motor tics?

Can Mexidol in injections

Olga Sat, 06/02/:53

Can Mexidol injections cause a miscarriage if the pregnancy was short?

The effect of the drug on

The effect of the drug during pregnancy has not been studied.

Good afternoon, tell me

Svetlana Tue, 09/02/:05

Good afternoon, please tell me whether it is possible to take Mexidol and gliatilin at the same time. A neurologist prescribed these medications to us; we are one year old. If not, please tell me what is better, thank you.

Can

These drugs do not interact with each other. For children only as prescribed by a doctor, after weighing the risks and expected benefits.

take before or after meals

Guest Tue, 15/03/:53

take before or after meals

Already answered the same question above

Guest Tue, 15/03/:11

The doctor has already answered the same question above.

If you miss a pill

Mark Thu, 04/07/:37

If you miss a Mexidol tablet, should you skip it or take a double one?

Take the next one as soon as

Take the next one as soon as you remember. No need to double.

Hello. The child is 11 months old.

Kukenova Dina Tue, 07/06/:03

Hello. The child is 11 months old. Diagnosis perinatal lesion Central nervous system of hypoxic-ischemic origin, mild severity, late recovery period. The neuropathologist prescribed Mexidol 1/4 tablet 2 times a day. 2 months. Is it dangerous to drink it for so long?

Use of the drug in

The use of the drug in childhood has not been sufficiently studied. The doctor prescribes the dosage and timing, weighing the risks and benefits.

Child 6 years old, a year ago

Irina Thu, 30/06/:00

The child is 6 years old, stuttering began a year ago. A pediatric psychoneurologist prescribed magnesium B6 - 1 tablet per day, Mexidol - 0.5 tablets, glycine - 1 t. twice a day. It helped a year ago. Now there is practically no effect. Maybe I need to increase the dose?

Is it possible to take Mexidol?

Natalya Tue, 06/09/:14

Is it possible to take Mexidol at the same time as glycine?

The interaction of these

No interaction of these drugs has been noted.

I took a pill at 9am

Galina Thu, 15/09/:02

At 9 am I took a Betaserc tablet. I was prescribed Mexidol tablets. Is it possible to take Mexidol on the same day at 17:00? Please tell me.

there were no pills in the pharmacy -

flura Wed, 02/11/:54

There were no tablets at the pharmacy, so I bought them in ampoules - can I just drink them?

Sveta Fri, 18/11/:11

I took a course of one tablet per day, does it have an effect or must it be taken as written in the instructions. How often can I take Mexidol? Is it addictive?

There shouldn't be any habituation.

There shouldn't be any habituation. Take as prescribed by your doctor.

I want to say a huge thank you

Margarita Fri, 31/03/:09

I would like to say a huge thank you to the neurologist who prescribed me Mexidol. I’ll be honest, I really don’t trust all the pills, I read a lot of reviews, some people praise me, some people don’t seem to feel anything, you don’t know whether to drink or not to drink, but my emotional health has already reached a critical point, chronic neurosis has already finished me off, Panic attacks also tormented me, I thought that I was almost in pre-stroke conditions, I lost my speech for half a minute, what strange reasoning, which I can’t remember later, in general, it’s not life, but hell. I bought the pills and started drinking. on the first day I drank 1 tablet in the morning and 1 tablet. in the evening, on the first day, I didn’t even understand this quick results, my head has become clear, the desire to live has returned, I can’t even express all my emotions, we’ll see what happens next, I’ve only been drinking for 2 days, thanks again to the doctor, who, one might say, got me back on my feet, but I still don’t understand what happened in one day such progress, although the reviews write that Mexidol has a cumulative effect. That's how it happens.

Mexidol and Mexicor are one thing

Nadezhda Wed, 05/24/:00

Are Mexidol and Mexicor the same thing?

The active ingredient is the same

The active ingredient is the same.

Tell me, should I take it?

Ruslan Tue, 30/05/:18

Tell me, you need to take it exactly 3 times a day, i.e. every 8 hours, or maybe in the morning, afternoon, and evening? Thank you.

Any drug is desirable

It is advisable to take any drug at the most equal intervals of time, for example at 7, 15 and 23

Thanks good prepor

Ivan Mon, 14/08/:44

Thank you, good drug.

My son (15 years old) was prescribed

Nadezhda Thu, 12/10/:06

My son (15 years old) was prescribed Mexidol, 1 tablet twice a day. My son has VSD and astheno neurotic syndrome. According to the instructions, you need to do it three times. How to use?

When receiving, always

When taking it, they always follow the doctor’s prescription, since the dosage is selected taking into account not only the diagnosis, but the characteristics of the patient - age, weight, test results, etc.

Mexidol analogue, which

Olga Thu, 12/10/:45

Please name an analogue of Mexidol that is cheaper!