Cocarboxylase - instructions for use, analogs, reviews and release forms (injections in ampoules for intravenous and intramuscular injections of hydrochloride) of a drug for the treatment of acidosis and coma in adults, children and pregnancy. Compound. Cocarboxylase - official

The use of Cocarboxylase reduces the concentration of pyruvic and lactic acid, improves glucose processing, has a positive effect on the trophism of nerve tissue, and normalizes the functionality of the cardiovascular system. If the body is deficient in this substance, the level of pyruvic acid in the blood increases, which can lead to the development of acidosis.

Release form and composition

Pharmacological action – coenzyme, metabolic. Pharmacological group – enzymes/metabolics, vitamin-like agents, vitamins.

Indications for use and price

The average price of cocarboxylase in ampoules and bottles is 110-115 rubles. You can buy cocarboxylase in pharmacies.

Application of cocarboxylase and indications:

• Diabetic, metabolic, respiratory acidosis(malfunctions of the acid-base state, they manifest themselves as a low blood pH level and a bicarbonate concentration below normal.
• Hypoglycemia, hyperglycemia (high and low sugar levels).
• Pathological processes occurring in the body, accompanied by disorders of carbohydrate metabolism. Diseases in this group can be hereditary or acquired. The most common are galactosemia, generalized glycogenosis, and diabetes mellitus.
• Hepatic, respiratory, renal, heart failure. Relevant for acute and chronic forms of diseases.
• Post-infarction cardiosclerosis– as a component of complex treatment of cardiovascular diseases, in more detail).
• Hepatic coma.
• Diabetic coma. (Very often occurs as a result of violations)
• Chronic alcoholism and acute alcohol poisoning.
• Poisoning with barbiturate drugs, digitalis.
• Paratyphoid fever, scarlet fever, diphtheria, typhus - as a component of complex therapy.
• Multiple sclerosis, peripheral neuropathy.
• Perinatal hypoxic encephalopathy, pneumonia, sepsis, respiratory failure in newborns.
• Conditions accompanied by acidosis and hypoxia.

Instructions for use and dosage

Instructions for the use of cocarboxylase injections and powders for preparing the solution:

• The drug Cocarboxylase is administered subcutaneously, intramuscularly or intravenously. The dose of the drug is prescribed individually, based on medical history, the patient’s condition and the severity of the disease.
• For adults, the drug is administered once - 50/100 mg. If necessary, as in the case of a diabetic coma, once every two to three hours. In the future, the prescribed therapy is maintained - 50 mg daily.
• For stable circulatory failure - strictly 50 mg two to three times daily, before taking digitalis medications. The course of procedures is 15-30 days.
• For diabetes mellitus - 100-1000 mg daily for 5-10 days, without stopping standard antidiabetic therapy.
• For acute renal or liver failure, burns, intoxication, 50-150 mg three times a day.
• For multiple sclerosis and peripheral neuritis, 50/100 mg daily for 30-45 days.

Contraindications

• High sensitivity to the drug.
• Hypovitaminosis Vitamin B1.
• Vitamin deficiency Vitamin B1.

During pregnancy and children

For children, the drug is administered intramuscularly or subcutaneously, except for newborn babies. They administer the drug sublingually.

These doses can be administered in two doses.

Medicine “Cocarboxylase” during pregnancy

The drug can be prescribed as prescribed by a doctor in several cases:

• Severe toxicosis. In such conditions, widespread metabolic disorders are observed. The drug helps improve carbohydrate metabolism, significantly stabilizing the woman’s condition. It is usually prescribed as part of a comprehensive treatment for toxicosis.
• Fetoplacental insufficiency. Doctors most often prescribe a ten-day course of injections, when the drug is administered intravenously. As a result, placental nutrition of the fetus is stabilized and uterine circulation improves.

Contraindications during pregnancy

• Increased sensitivity to the drug.
• Tendency to develop allergic reactions.

How to prevent cocarboxylase deficiency during pregnancy

The drug is an active form of vitamin B1, therefore, in order to avoid deficiency, it is recommended to consume foods high in this substance: liver, porridge - buckwheat and oatmeal, pork, veal, cauliflower.

Cocarboxylase is a metabolic enzyme of natural origin. However, safety during pregnancy has been proven only theoretically, not one hundred percent. No long-term studies have been carried out on this matter.

Overdose and side effects

• Symptomatic treatment is carried out aimed at stabilizing cardiovascular activity and respiratory rhythm.
• Discontinuation of the drug.

As a rule, an overdose does not occur.

• Skin itching, urticaria and others
• In the case of intramuscular injection, there is swelling and itching at the injection site.

Analogues

• “Ferein cocarboxylase.”
• “Improv cocarboxylase.”
• “Hydrochloride cocarboxylase.”
• “Ellara cocarboxylase.”

All drugs have exactly the same active ingredient and release form.

Cocarboxylase and ATP

1. Therapy of tuberculosis in children of early and adolescent age. Doctors often classify drugs that stimulate energy metabolism as pathogenetic therapy. Scientific research has established that under the influence of tuberculosis intoxication or in oncology in the case of long-term chemotherapy, unfavorable changes develop in energy metabolic processes, in particular in the heart muscle. With the development of pulmonary tuberculosis, hypoxia occurs, which leads to increased anaerobic glycolysis. As a result, under-oxidized products accumulate, so it is advisable to use cocarboxylase and ATP in the complex treatment of patients.
2. The drug has a positive effect on internal metabolic processes, has a beneficial effect on myocardial trophism. When anti-tuberculosis drugs are combined with cocarboxylase and ATP, the symptoms of intoxication disappear much faster. The course is usually formed by 10-15 injections, depending on the severity of the disease.
3. For multiple sclerosis Alternating injections of cocarboxylase and ATP becomes part of complex therapy.

A cardiovascular drug, the main active ingredient of which is called cocarboxylase. In the human body, “Cocarboxylase” is formed from Thiamine and takes part in carbohydrate and fat metabolism. Promotes the synthesis of acetyl-coenzyme A.

Reviews:

Maria Mikhailovna 33 years old

I had very severe and debilitating toxicosis, my weight dropped by 6 kg, the doctor considered it necessary to prescribe cocarboxylase. The drug was administered intravenously and the suffering was alleviated after ten injections. Then a healthy baby was born.

Victor Fedorovich 47 years old

I was prescribed the drug after suffering a cardiovascular disease. No significant changes were noticed, but the doctor said that positive dynamics were emerging.

A.11.D.A Vitamin B1

Thank you

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

Dosage form

Properties and action

Cocarboxylase is endogenously synthesized from vitamin B1 and is a coenzyme. Coenzymes (coenzymes) are components of enzymes - proteins that serve as catalysts for all biochemical reactions. The functions of coenzymes are usually performed by vitamins. Cocarboxylase is a coenzyme of enzymes that regulate saccharide metabolism. In combination with protein and magnesium ions, it is an integral part of the carboxylase enzyme, which serves as a regulator of saccharide metabolism, prevents the accumulation of lactic and pyruvic acids in the body, and stimulates the absorption of glucose. All this contributes to more efficient energy production, which means improved metabolism throughout the body.

Thiamine, entering the body, is first broken down into cocarboxylase, and only in this form does it take part in metabolic processes. Thus, cocarboxylase is the active form of coenzyme obtained from thiamine during its endogenous breakdown. However, the biochemical properties of thiamine pyrophosphate are not identical to the properties of thiamine, therefore cocarboxylase is not used in the treatment of diseases caused by vitamin B1 deficiency. It is used in complex therapy for various pathological conditions that require stabilization of carbohydrate metabolism.

Thiamine pyrophosphate promotes the absorption of glucose, normalizes metabolism in nervous tissue, and restores the functions of the heart muscle. A lack of cocarboxylase leads to an imbalance in the acid-base balance of the blood (acidosis), which leads to severe pathologies of all organs and systems, and can lead to coma and death.

The effectiveness of cocarboxylase has been proven by many clinical studies.

Indications and contraindications

• with acidosis that has developed due to metabolic disorders in various pathologies, for example, during a diabetic crisis (fainting due to a high concentration of blood glucose);
• for respiratory and heart failure, incl. in newborns;
• for chronic cardiovascular failure;
• with ischemic heart disease, incl. pre-infarction conditions, myocardial infarction, post-infarction conditions;
• in cases of impaired liver and kidney function;
• with alcohol abuse;
• for toxicosis caused by certain medications (glycosides, barbiturates);
• for infectious diseases (diphtheria, typhus, etc.);
• for pathologies of the nervous system (pain and inflammatory reactions of peripheral nerves, multiple sclerosis, etc.);
• for brain pathologies in newborns caused by hypoxia;
• for any conditions characterized by impaired saccharide metabolism.

Thiamine pyrophosphate is contraindicated for use in case of individual intolerance.
It is recommended to obtain medical advice before using the drug.

Side effects and symptoms of overdose

Composition and release form of the drug

Lyophilisate for preparing a solution for intravenous and intramuscular administration in the form of a powder or dry porous hygroscopic mass of white color with a characteristic odor.

Excipients: sodium carbonate - 8 mg.

50 mg - ampoules (5) - contour blister packs (1) - cardboard packs.
50 mg - ampoules (5) - contour blister packs (2) - cardboard packs.
50 mg - ampoules (5) complete with solvent 2 ml amp. 5 pieces. - contour cellular packaging (1) - cardboard packs.

pharmachologic effect

A coenzyme produced in the body from. Has a metabolic effect, activates tissue metabolism. In the body it is phosphorylated to form mono-, di- and triphosphoric esters; cocarboxylase is part of enzymes that catalyze the carboxylation and decarboxylation of keto acids, pyruvic acid, and promotes the formation of acetyl coenzyme A, which determines its participation in carbohydrate metabolism. Participation in the pentose cycle indirectly promotes the synthesis of nucleic acids, proteins and lipids.

Improves absorption, trophism of nervous tissue, helps normalize the functions of the cardiovascular system.

Cocarboxylase deficiency causes an increase in the level of pyruvic and lactic acids in the blood, which leads to acidosis and acidotic coma.

Indications

As part of combination therapy: metabolic acidosis, acidosis in hyperglycemic coma, acidosis in respiratory and pulmonary heart failure; chronic failure, ischemic heart disease, unstable angina, myocardial infarction, post-infarction cardiosclerosis; liver and/or renal failure, acute and chronic alcoholism, poisoning, intoxication with cardiac glycosides and barbiturates, infectious diseases (diphtheria, scarlet fever, paratyphoid fever), neuralgia, multiple sclerosis, peripheral neuritis.

In children during the neonatal period: perinatal hypoxic encephalopathy, respiratory failure, pneumonia, sepsis, hypoxia, acidosis.

Contraindications

Hypersensitivity to cocarboxylase.

Dosage

Adults are administered intramuscularly or intravenously. The dose is 50-200 mg/day. For diabetes mellitus (acidosis, coma), the daily dose can be 0.1-1 g. The frequency and duration of use depends on the indications.

Cocarboxylase is a drug that has a metabolic effect and activates tissue metabolism.

Pharmacological action of Cocarboxylase

Cocarboxylase is a coenzyme of enzymes that are involved in carbohydrate metabolism. Exogenous Cocarboxylase is formed during the metabolism of thiamine.

The drug takes an active part in the processes of decarboxylation of alpha-keto acids. In addition, the drug affects the pentose phosphate pathway of glucose breakdown. Cocarboxylase improves the absorption of glucose, while reducing the level of lactic acid in the body, improves the trophism of tissues of the peripheral as well as the central nervous system. In addition, the drug affects the functioning of the cardiovascular system.

According to the instructions, Cocarboxylase is used for the treatment of hypo- and vitamin B1 deficiency. The drug is excreted from the body by the kidneys.

Directions for use and dosage

The medicinal product is intended for the preparation of a solution for parenteral use. According to the instructions, Cocarboxylase must be diluted in 2 milliliters of water for injection. The drug should be dissolved immediately before injection.

The injection solution can be administered in several ways: intramuscularly, subcutaneously and intravenously. The duration of treatment and dose are prescribed individually for each patient.

• According to the instructions, adults are prescribed 50-100 milligrams intramuscularly once a day.
• If an adult has a serious condition, experts prescribe 50-100 milligrams every 2 hours. Injections are administered intramuscularly. After this, you need to switch to a maintenance dose - 50-100 milligrams.
• It is advisable to use Cocarboxylase in children under 3 months of age in the form of subcutaneous administration of the drug. Dose – 25 milligrams once a day.
• For children aged from 4 months to 7 years, experts prescribe subcutaneous or intramuscular injection of a solution of 25-50 milligrams once a day.
• For children over 8 years of age, it is recommended to administer 50-100 milligrams of the drug intramuscularly once a day.

If necessary, specialists can divide the daily dose of Cocarboxylase into two administrations.

Indications for use

The drug is prescribed to patients who suffer from liver and kidney failure, and hepatic coma. In addition, Cocarboxylase is prescribed as a treatment for precomatose conditions.

Cocarboxylase should be used by patients who have acidosis due to diabetes mellitus, as well as people suffering from respiratory acidosis due to pulmonary heart failure.

The drug is indicated for multiple sclerosis, heart disease, atrial fibrillation, and paroxysmal tachycardia. Cocarboxylase is also prescribed for neuritis, as well as for pathologies associated with impaired carbohydrate metabolism.

Use during pregnancy

Cocarboxylase may be prescribed during pregnancy if the expected benefit to the woman significantly outweighs the potential risks to the child. If it is necessary to use the drug during lactation, you should consult a specialist and decide whether to interrupt breastfeeding of the baby.

Cocarboxylase during pregnancy, if pathologies in the development of the fetus are observed, is strictly prohibited.

Contraindications

The drug should not be prescribed if you are hypersensitive to cocarboxylase hydrochloride. According to reviews, Cocarboxylase can cause allergic reactions on the skin, including itching and redness. The formation of urticaria is possible.

The drug should not be prescribed to patients with atrial fibrillation. According to reviews, Cocarboxylase can cause redness on the skin, itching and swelling of the tissue at the site where the injection was made.

Overdose

In case of an overdose of the drug, the severity of side effects may increase, and disorders of the respiratory or cardiovascular systems may also occur.

According to reviews, Cocarboxylase does not have a specific antidote. In case of overdose, the drug should be discontinued and symptomatic therapy should be carried out, as well as measures to maintain the functions of the respiratory and cardiovascular systems.

Interaction with other drugs

According to reviews, Cocarboxylase, when used in combination, enhances the therapeutic effects of cardiac glycosides.

According to the instructions, mixing the drug in the same syringe with other medications is strictly prohibited. It is permissible to use only the solvent that is in the box along with the drug.

Conditions and shelf life

The shelf life of the drug is 3 years. After the solution has been prepared, it must be used immediately. According to reviews, Cocarboxylase should be stored away from children, in a dry and dark place.

The drug must be stored at a temperature not exceeding 25 degrees Celsius.

Compound

One bottle of powder contains: cocarboxylase hydrochloride - 50 milligrams and excipients.

One ampoule with solvent contains: water for injection – 2 milligrams.