Why is Piracetam prescribed and what to expect from the medicine in different cases? Piracetam tablets - official instructions for use

Attention! The information is provided for informational purposes only. This instruction should not be used as a guide to self-medication. The need for prescription, methods and doses of the drug are determined exclusively by the attending physician.

general characteristics

Compound: 1 tablet contains piracetam 0.2 g;

Additional substances: potato starch, polyvinylpyrrolidone, basic magnesium carbonate, calcium stearate, refined sugar, aerosil, titanium dioxide, tartrazine, beeswax,
sunflower oil.

Pharmacotherapeutic group

Nootropic drug.

Cautions

Before starting treatment, consult your doctor!
Piracetam should be taken with caution while driving vehicles or operating machinery.

Pharmacodynamics

Pharmacodynamics: Piracetam enhances synthesis dopamine (Dopamine- mediator nervous system from the group of catecholamines, a neurohormone. Biochemical precursor of norepinephrine and adrenaline. Produced nerve endings, as well as chromaffin cells) in brain tissue, increases the content norepinephrine (Norepinephrine- a compound from the group of catecholamines, a neurohormone. Formed in the adrenal medulla and in the nervous system, where it serves as a mediator (transmitter) of conduction nerve impulse through the synapse. Increases blood pressure, stimulates carbohydrate metabolism and etc.), increases the amount of acetylcholine at the synaptic level and the density of cholinergic receptors. The drug has a positive effect on metabolic processes and blood circulation in the brain, stimulates redox processes, improves utilization glucose (Glucose - grape sugar, a carbohydrate from the group of monosaccharides. One of the key metabolic products that provides living cells with energy), regional blood flow in ischemic areas of the brain increases the energy potential of the body with the participation of ATP and adenylate cyclase. Optimization of energy processes improves durability CNS (CNS- the main part of the nervous system, represented by the spinal cord and brain. Functionally, the peripheral and central nervous systems represent a single whole. The most complex and specialized part of the central nervous system is the cerebral hemispheres) to hypoxia and various toxic (Toxic- poisonous, harmful to the body) factors. Piracetam improves the integrative activity of the brain, promotes memory consolidation, and improves learning processes.

Method of use and dosage

Piracetam is taken orally before meals, starting with 1.2 g (2 tablets 3 times a day) and increasing the dose to 2.4 g (sometimes up to 3.2 g or more) per day. In the future, the dose should be reduced to 1.2 -1.6 g (2 tablets 3-4 times a day).
The course of treatment with the drug ranges from 2 - 3 weeks to 2 - 6 months and, if necessary, is repeated after 6-8 weeks.
Overdose may cause irritation, insomnia, tremor (Tremor(trembling) - rhythmic repetitive movements that occur in any part of the body). In elderly patients, exacerbation of heart failure is possible.
In this case, you should consult a doctor.

For children: Children take: from 1 to 5 years - 1 tablet 3 times a day (up to 0.8 g per day); from 5 to 16 years - 2 tablets (0.4 g) 3 times a day. Maximum daily dose- 1.8 g.

Side effects

Piracetam is generally well received. In some patients it is possible increased irritability, anxiety, sleep disturbance, dyspeptic symptoms; exacerbations may occur in elderly patients coronary (Coronary- a surrounding organ in the form of a crown (crown), related to the coronary arteries of the heart, for example, coronary circulation) insufficiency (the dose should be reduced or the drug should be stopped). Possible allergic reactions, manifestation of individual intolerance.
If any unusual reactions occur, be sure to consult your doctor regarding further use of the drug!

Indications for use

Neurology: vascular parkinsonism (Parkinsonism– a neurological syndrome caused by a malfunction of the metabolism of adrenaline, norepinephrine, dopamine and their ratio in the subcortical nerve nodes (ganglia). Characterized by rhythmic muscle tremor (fingers, sometimes lips and other parts of the body tremble), rigidity, decreased volume and speed of movements, hypokinesia), other pathological processes with phenomena chronic (Chronic- a long, continuous, protracted process, occurring either constantly or with periodic improvements in the condition) cerebrovascular insufficiency, memory impairment, attention, speech, dizziness. Diseases nervous system (Nervous system- a set of formations: receptors, nerves, ganglia, brain. Performs the perception of stimuli acting on the body, conducts and processes the resulting excitation, and forms responses adaptive reactions. Regulates and coordinates all functions of the body in its interaction with external environment) with a decrease in intellectual-mnestic functions and disturbances in emotional volitional sphere.
Psychiatric, neurotic and asthenoadynamic depressive states with predominant signs of adynamia, asthenic, senesto-hypochondriacal disorders, ideational inhibition, flaccid apathetic defective states, schizophrenia (Schizophrenia(from the Greek schizo - divide, split and phren - mind, thought) - mental illness\; main manifestations: personality changes (decreased activity, emotional devastation, autism, etc.), various so-called pathological productive symptoms(delusions, hallucinations, affective disorders, catatonia, etc.). The course is predominantly chronic (in the form of attacks or continuous). Occurs more often in at a young age) , psychoorganic syndromes of various etiologies, senile and atrophic processes, complex therapy (Therapy- 1. The field of medicine that studies internal illnesses, one of the oldest and main medical specialties. 2. Part of a word or phrase used to indicate the type of treatment (oxygen therapy\; hemotherapy - treatment with blood products)) mental illness.
Complex therapy for senile dementia (Dementia- acquired dementia, which is a breakdown of mental functions resulting from brain damage), including Alzheimer's disease (Alzheimer's disease- a degenerative disease of the brain, manifested primarily by intellectual impairment. The neurons of the cortex and hippocampus die off, the disease progresses steadily).
Pediatrics (Pediatrics- a field of medicine that studies the characteristics child's body, causes and mechanisms of development of childhood diseases and developing methods of their treatment): cerebrosthenic, encephalopathic disorders, memory disorders, intellectual disability.
At chronic alcoholism e Piracetam is prescribed to reduce symptoms asthenia (Asthenia (asthenic syndrome) - the patient’s condition, which manifests itself increased fatigue, frequent changes mood, irritable weakness, hyperesthesia, tearfulness, autonomic disorders and sleep disorders), intellectual-mnestic and other disorders mental activity.
Complex therapy

Release form: Solid dosage forms. Pills.



General characteristics. Compound:

Active ingredient: 400 mg piracetam.

Excipients: potato starch, polyvinylpyrrolidone, calcium stearate, basic magnesium carbonate, film-forming coating Opadry II (polyvinyl alcohol; talc; polyethylene glycol 3350; lethicin (soy); iron oxide E 172).

Piracetam has positive influence on metabolic processes and blood circulation in the brain.


Pharmacological properties:

Pharmacodynamics. Stimulates redox processes, enhances glucose utilization, improves regional blood flow in ischemic areas of the brain. Increases the body's energy potential by accelerating ATP turnover, increasing the activity of adenylate cyclase and inhibiting nucleotide phosphatase. Improvement in energy processes under the influence of piracetam leads to increased resistance of brain tissue to toxic influences. Piracetam improves the integrative activity of the brain, promotes memory consolidation, improves learning processes, restores and stabilizes impaired brain functions. When used at a dose of 9.6 g, it reduces the level of fibrinogen and von Willebrand factors by 30-40% and prolongs the time.

Pharmacokinetics. Suction. After oral administration, piracetam is quickly and almost completely absorbed from gastrointestinal tract. Bioavailability is approximately 100%. After a single dose of the drug in a dose of 2 g, the maximum concentration (Cmax), amounting to 40-60 mcg/ml, is achieved after 30 minutes in the blood plasma and after 5 hours in the cerebrospinal fluid.

Distribution. The apparent volume of distribution (Vd) is approximately 0.6 l/kg. Penetrates through the blood-brain and placental barriers, as well as through membranes used in hemodialysis. In animal studies, it was found that piracetam selectively accumulates in the tissues of the cerebral cortex, mainly in the frontal, parietal and occipital lobes, in the cerebellum and basal ganglia.

Metabolism. Does not bind to blood plasma proteins and is not metabolized in the body.

Excretion. The half-life (T1/2) is 4-5 hours from blood plasma and 8.5 hours from cerebrospinal fluid. After 30 hours, 80-100% of piracetam is excreted unchanged by the kidneys by renal filtration. Renal clearance piracetam in healthy volunteers is 86 ml/min. T1/2 lengthens at . The pharmacokinetics of piracetam does not change in patients with liver failure.

Indications for use:

Piracetam is prescribed to adults and children for various diseases nervous system, especially those associated with vascular disorders and pathology metabolic processes brain, including in elderly and senile people.

IN neurological practice prescribed for cerebral atherosclerosis, vascular parkinsonism and other diseases with symptoms chronic failure cerebral circulation, manifested in impaired memory, attention, speech, dizziness, etc., as well as in comatose and subcomatose states after brain injuries and intoxications during rehabilitation therapy after such conditions. It is also used for diseases of the nervous system, accompanied by a decrease in intellectual-mnestic functions and disturbances in the emotional-volitional sphere.

In psychiatric practice, piracetam is used in patients with neurotic and asthenoadynamic depressive states of various origins with a predominance in clinical picture signs of adynamia, asthenic and senesto-hypochondriacal disorders, phenomena, as well as in flaccid apathetic defective states in patients with schizophrenia, with psychoorganic syndromes of various etiologies, senile and atrophic processes, in complex therapy various.

The drug can also be used as aid in the treatment of patients with depressive conditions, resistant to antidepressants, as well as poor tolerance to neuroleptics and other psychotropic drugs in order to eliminate or prevent the somatovegetative, neurological and mental complications caused by them.

Piracetam is widely used in gerontological practice (due to the improvement of integrative, cognitive functions of the brain). Piracetam can be used in complex therapy senile dementia(including Alzheimer's disease).

Piracetam has a positive effect in patients coronary disease hearts in the elderly and old age. Due to its antihypoxic effect, it is recommended to use piracetam in complex treatment patients with myocardial infarction.

Piracetam is also used in pediatric practice for various cerebroasthenic, encephalopathic disorders, memory disorders, intellectual disability, etc.

It is advisable to use piracetam to reduce the phenomena of hypoxia and cerebral ischemia in acute viral neuroinfections.

Piracetam is also used to relieve withdrawal, pre- and delirious states in alcoholism and drug addiction, as well as in cases of acute, morphine, barbiturates, etc. The use of piracetam in a complex of means for the relief of acute phenomena alcohol withdrawal reduces the severity of cerebral vascular disorders, reduces headaches, feelings of apathy, drowsiness.

In chronic alcoholism, piracetam is prescribed to reduce the phenomena of asthenia, intellectual-mnestic and other mental disorders.


Important! Get acquainted with the treatment, ,

Directions for use and dosage:

During treatment chronic conditions Piracetam is taken orally (before meals), with plenty of water (100-200 ml), starting with 1.2 g (400 mg 3 times a day), and adjusting the dose to 2.4 g, sometimes to 3.2 g and more per day. Therapeutic effect in these cases, it is noted, as a rule, after 2-3 weeks. after starting treatment. Subsequently, the dose is reduced to 1.2-1.6 g (400 mg 3-4 times a day).

The course of treatment with piracetam lasts from 2-3 weeks. up to 2-6 months If necessary, it is repeated after 6-8 weeks.

Children under 5 years old are prescribed 800 mg per day, from 5 to 16 years old - 1200-1600 mg per day.

Features of application:

Pregnancy and lactation. The use of the drug during pregnancy is contraindicated. If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.

Influence on the ability to drive vehicles and operate machinery. There are no contraindications.

Side effects:

From the nervous system and sensory organs: dizziness, headache, in elderly patients - anxiety, irritability, condition internal tension, excitement, aggressive behavior, sleep disorder, increased physical activity.

From the side of cardio-vascular system and blood: arterial hypo- or hypertension, exacerbation of coronary insufficiency.

Overdose:

Symptoms: increased side effects.

Treatment: symptomatic therapy.

Vacation conditions:

On prescription

Package:

Tablets 400 mg, 10 tablets in a blister pack.

2, 3 strip packaging along with instructions for use in a box of cardboard.

"Piracetam" - nootropic drug, which improves blood circulation in the brain and affects metabolism in the cortex of this organ. The medicine protects the most main body in case of violations caused by mental disorders. Piracetam, the indications for use of which are listed below, is used for memory impairment, decreased concentration, Alzheimer's disease, traumatic brain injuries, and is used for chronic alcoholism and learning disabilities in children.

Piracetam - indications for use of the drug

The substance is a white crystalline powder used in medicine in the most different cases, easily dissolves in water and alcohol. This drug is simply necessary in any home medicine cabinet to ensure health safety. Medicinal properties Piracetam helps improve brain activity, sensitivity, and enhance memory and attention. This drug can be useful and is prescribed when psychiatric, neurological and drug addiction disorders or problems occur.

Indications for use in neurology

Piracetam can help with vascular diseases brain, memory impairment, speech impairment, dizziness. In addition, the drug is prescribed for headaches (migraines). The drug normalizes blood circulation in the brain, helps with senile dementia (a disease similar to Alzheimer's disease). The drug prevents many diseases of the nervous system, including disorders accompanied by a decrease in intellectual functions.

Psychiatry

Universal in some way, Piracetam is used for prescriptions by psychiatrists. The medicine is prescribed when treating depressive states of certain mental illnesses (drips, injections). The drug is part of a treatment regimen for the serious disease epilepsy, and helps with many other complications associated with mental disorders in adults and young patients.

Narcology

Modern medicine helps in the treatment of addiction diseases. Here's some of them:

  • chronic alcoholism with impaired mental activity of a person,
  • alcohol poisoning,
  • morphine poisoning,
  • poisoning with phenamines and butyrates.

With such serious violations The dose of the drug should be determined by the attending physician. Any attempts to make an appointment on your own, on the recommendation of work colleagues or housemates, end in failure. IN difficult cases You should not rely on an incompetent opinion; it is better to trust a professional.

Pediatrics

Piracetam is used in the treatment of diseases not only in adults, but also in young children. It can be used if necessary:

  • accelerating the process of formation and elimination of the consequences of brain damage,
  • with oligophrenia, delay mental development,
  • for children cerebral palsy.

In these cases, such medicine (in injections, tablets) can be very useful for a sick child, since it is very effective. Due to its composition, “Piracetam” is not recommended for children under one year of age for their safety, however, there are exceptions when the risk from taking it is less than the threat to the baby’s life. At this point, you must rely entirely on children's doctor.

Instructions for use and dosage for adults and children

Be sure to read the instructions for the drug and check the dosage based on the age and condition of the patient. Such actions will eliminate the chance of harm to the patient’s health.

  • Older patients should take 800 mg orally at the beginning of treatment three times a day before meals. At further treatment as the condition improves, the dosage is reduced to 400 mg. The course of treatment can last from 2-3 weeks to 2-6 months. If necessary, the drug is re-prescribed.
  • For alcoholism, the patient is given only 12 grams per day, provided complete failure from alcohol.
  • When treating childhood dyslexia, children over 8 years of age are prescribed 3.2 grams, dividing this amount into two equal doses in the morning and evening.

Tablets or capsules

The patient himself decides what to buy – tablets or capsules; everything depends on the physical characteristics of the patient’s body. A contraindication to one or another type of Piracetam is intolerance. The right decision would be to visit your doctor for consultation and prescriptions. Unlike capsules, tablets dissolve very slowly, but are more effective type drug.

Injections

"Piracetam" in ampoules is administered by injection intravenously, intradropwise and intramuscularly. Quantity, rate of administration, dosage - all this is the prerogative of the attending physician, who has studied the patient’s history and condition in detail. So, for a disease such as sickle cell vaso-occlusive crisis, the patient is administered intravenously 300 mg/kg per day, dividing the dose into 4 equal portions.

Contraindications for use

When taking Piracetam, you should strictly adhere to the dosage. If the patient uses large quantity drug, this may have a negative (if not worse) effect on his health. An overdose of the drug leads to irritability, deterioration of the heart muscle and insomnia. Before taking pills, you should study which medications interact and which cannot be prescribed in parallel in order to avoid unpleasant situations.

When using the drug and other drugs simultaneously, care must be taken when administering vehicle and other activities requiring increased concentration and attention. You should also not take Piracetam if you have a hemorrhagic stroke, kidney failure, or individual intolerance to the drug.
It is forbidden to take the drug for pregnant women and women during lactation.

The medicine may cause such side effects:

  • nausea;
  • vomiting;
  • weakness;
  • drowsiness;
  • headache;
  • anxiety;
  • restlessness;
  • imbalance;
  • apathy.

In some cases, after taking the drug, allergic reactions, sleep disturbances, and inattention may occur. In elderly patients, the drug sometimes causes coronary insufficiency. Patients taking Piracetam should be informed about side effects and interactions with other drugs.

Approximate cost of the drug in tablets and ampoules

Piracetam can be purchased at any pharmacy with a doctor's prescription. The cost of this tablet form of the drug is approximately 250 rubles. Eat various analogues of these tablets (determined by active substance), therefore you need to consult a doctor to clarify the name of the medicine that was prescribed to you. Price of "Piracetam" for intramuscular and intravenous injections starts from 32 rubles per piece, while the drug imported production costs more than domestic ones.

Why is Piracetam prescribed to patients? You will learn the answer to this question from this article. We will also provide you with information on how this medication should be taken, in what form it is available, whether it has side effects and contraindications, and whether it can be used during lactation and pregnancy.

Forms of release of the drug, packaging and composition

Before telling you why Piracetam is prescribed by doctors, we should tell you in what form it can be purchased in pharmacies.

Today there are several forms of this drug. Let's look at them in more detail.

  • Capsules. This form of the drug contains 0.4 g of piracetam and is sold in cardboard packs of 60 pieces.
  • 20% solution. This form Sold in ampoules of 5 ml, which, in turn, are placed in cardboard packages of 10 pieces.
  • coated yellow color and contains 0.2 g active substance. You can buy tablets in cardboard packs of 120 or 60 pieces.
  • Granules for babies. The drug has a light pink color (a brownish sediment is acceptable) and is available in glass jars of 56 g.

It should also be noted that each form of the drug has its own excipients.

Pharmacodynamics of the drug

Why can Piracetam be prescribed to a person? This is able to have a positive effect on the blood circulation of the brain and its metabolic processes.

The medication improves metabolic processes and increases glucose utilization. It also inhibits the aggregation of activated platelets.

Taking Piracetam has a protective effect against brain damage caused by electric shock, intoxication or hypoxia. In addition, this drug improves the integrative functioning of the brain without producing a psychostimulating or sedative effect.

Properties of the drug

What properties does the drug “Piracetam” have? What is this remedy prescribed for? The medication in question is capable of activating associative processes in the central nervous system, as well as improving mood and memory in both sick and healthy people.

Why can Piracetam be prescribed to children? This tool can increase intellectual activity, increase mental performance, facilitate improvement of conductivity (synaptic) in the cerebral cortex and connections between its hemispheres (left and right). The drug also restores and stabilizes impaired speech, memory and consciousness.

The principle of action of the drug

How does Piracetam work? What is it used for by young people and the elderly?

The drug in question normalizes the ratio of ATP and ADP, and also activates phospholipase A, accelerates the exchange of neurotransmitters and helps stimulate plastic and bioenergetic processes in nerve tissues.

Why can Piracetam (injections, powder, capsules and tablets) be prescribed to patients? This drug is able to block platelet aggregation, improve microcirculation and optimize the process of passage of red blood cells through microscopic vessels.

It should also be noted that this drug increases regional blood circulation in ischemic areas of the brain, enhances alpha and beta activity, but at the same time reduces delta activity.

The medication reduces vestibular nystagmus. During hypoxia, injury and intoxication, it has a neuroprotective effect.

Due to antihypoxic properties this drug very effective in complex therapy of myocardial infarction.

Pharmacokinetics of the drug

How long does it take for the medication “Piracetam” to be absorbed (we will explain later why this drug is prescribed)? After oral administration, the drug is quickly and completely absorbed. Its bioavailability is one hundred percent.

Oral administration of the drug in an amount of 2 g gives maximum plasma concentration after thirty minutes. The product does not bind to proteins and penetrates all organs and tissues, including through the placental barrier.

The drug is practically not metabolized, but selectively accumulates in the parietal, occipital and frontal regions of the brain, as well as in the cerebellum and basal ganglia.

The half-life of this drug is five hours. About 95% of the drug is excreted unchanged in the urine (after about thirty hours). In people with renal failure this period of time increases.

What is Piracetam used for? Indications for use

The nootropic in question has wide range actions. According to the instructions, indications for its use are the following conditions:

  • ischemic stroke, as well as all its consequences;
  • cerebrovascular insufficiency of a chronic nature (for example, atherosclerosis, hypertension or vascular parkinsonism), accompanied by headaches, dizziness, impaired memory, speech and attention;

  • dementia (including Alzheimer's disease);
  • aphasia;
  • viral neuroinfection (acute);
  • diseases of the nervous system, accompanied by a decrease in intellectual and mnestic functions, the degree of wakefulness, as well as a violation of the emotional and volitional sphere, behavior;
  • intoxication (including recovery period, subcomatose and;
  • dizziness;
  • psychoorganic disorders;
  • lethargic and apathetic state;
  • cortical myoclonus;
  • traumatic brain injuries;
  • epilepsy (as an adjuvant);
  • vestibular nystagmus;
  • atrophic and senile processes.

For what other deviations is Piracetam prescribed? Why do they drink this medicine and give injections? In addition to the above, this medication also has the following indications:

  • neurological, somatovegetative, mental complications that arose after treatment psychotropic drugs and neuroleptics;
  • acute intoxication with amphetamine, ethanol, barbiturates or morphine;
  • depressive conditions resistant to treatment with antidepressants;
  • neurotic depression with asthenic and senesto-hypochondriacal disorders, as well as adynamia and symptoms of ideomotor retardation;
  • withdrawal, pre- and delirious states in alcoholism and drug addiction;
  • psychoorganic syndrome in alcoholism (chronic);
  • sickle cell anemia (in complex treatment).

Why do doctors often recommend Piracetam tablets, as well as capsules and powder, to their young patients? This drug is prescribed for cerebral palsy, mental retardation, the consequences of low learning (with psychoorganic syndrome), mental retardation, speech disorders, memory impairment and intellectual disability.

Lactation and pregnancy period

Is it possible to take Piracetam during pregnancy? What is it for? Some experts prescribe the drug in question to pregnant women according to indications. However, it should be recalled that this medication easily penetrates the placental barrier, as well as into breast milk. In this regard, it is contraindicated during lactation and pregnancy. Otherwise, this may have a detrimental effect on the child's health.

Contraindications

In what cases should Piracetam not be used (injections, oral forms)? This drug is not prescribed for hypersensitivity (including to pyrrolidone derivatives), as well as Huntington's disease, severe renal failure, pregnancy, agitated depression, and breastfeeding. Also, this medication should not be given to children under one year of age.

Methods of application

Now you know why Piracetam tablets can be prescribed to patients. Now I should tell you how to take this remedy.

At the beginning of therapy, a piracetam solution is administered intravenously at a dose of 10 g. Then the amount of medication is reduced and switched to oral administration. The drug is taken orally before meals in a dosage of 800 mg (in 3 divided doses). After the condition improves, the amount of the drug is reduced to 400 mg. The duration of such treatment is 6-8 weeks.

It should be especially noted that daily dosage The medication "Piracetam" can be different and depend on the type and severity of the disease. As for the duration of treatment, it is determined only by the doctor according to the data of a medical examination.

For children, this drug is prescribed no more than 30-50 mg per day. In this case, therapy should be long-term. The oral solution is given to the child 2 times a day (morning and evening). It is allowed to be added to fruit juice or other drinks.

Adverse reactions

Can it cause undesirable consequences use of the drug "Piracetam"? Injections, as well as oral forms of the drug, can indeed cause adverse reactions. The most common ones include the following:

  • Metabolism: increased body weight.
  • Sense organs and nervous system: drowsiness, hyperkinesia, depression, increased irritability, asthenia, agitation, aggression, sleep disorder, increased sexuality, dizziness, tremor and headache.
  • Digestive tract: vomiting, abdominal pain, diarrhea and nausea.
  • Skin: hypersensitivity.
  • Blood circulation: hypertension, coronary insufficiency(in the acute stage).

Overdose

An overdose of Piracetam increases all side effects. Treatment includes gastric lavage and absorption of absorbent agents.

Name:

Name: Piracetamum

Indications for use:
The drug is prescribed for cerebral atherosclerosis, vascular parkinsonism, and other pathological processes with symptoms of chronic cerebrovascular insufficiency with impaired memory, attention, speech, dizziness, with changes in cerebral circulation, comatose and subcomatose states as a result of brain injuries and intoxications. Used for diseases of the nervous system with a decrease in intellectual-mnestic functions and disorders of the emotional-volitional sphere. In psychiatric practice they are used for neurotic and asthenoadynamic depressive states with the advantage of signs of adynamia, asthenic, senesto-hypochondriacal disorders, ideational inhibition, with flaccid apathetic defective states, with schizophrenia, with psychoorganic syndromes of various etiologies, senile and atrophic processes, in complex therapy of mental illnesses. Prescribed in the complex treatment of senile dementia, including Alzheimer's disease. In pediatrics, Piracetam is used for cerebrosthenic and encephalopathic disorders.
Piracetam is used for emergency care with withdrawal symptoms, extreme delirious and delirious states with alcoholism, drug addiction, in case of acute poisoning alcohol, morphine, barbiturates. In chronic alcoholism, Piracetam is prescribed to reduce the phenomena of asthenia, intellectual-mnestic and other mental disorders. The drug is advisable to use for viral neuroinfections to reduce cerebral ischemia and hypoxia. The antihypoxic effect of the product should be taken into account in the complex therapy of myocardial infarction.

Pharmachologic effect:
Piracetam enhances the synthesis of dopamine in the brain and increases the content of norepinephrine. The drug also increases the amount of acetylcholine at the synaptic level and the density of cholinergic receptors. GABAergic elements cannot be excluded from the action of the product, despite the fact that it does not convert into GABA. The drug has a positive effect on the processes of metabolism and blood circulation in the brain, stimulates redox processes, increases glucose utilization, improves regional blood flow in ischemic areas of the brain, increases the energy potential of the body with the participation of ATP and adenylate cyclase. Optimization of energy processes helps to increase the resistance of the central nervous system to hypoxia and various toxic factors. Piracetam improves integrative brain activity, promotes memory consolidation, and improves learning processes.
Pharmacokinetics. When introduced into the body it penetrates into different organs and tissues, including brain tissue. Practically not metabolized. Excreted by the kidneys. The half-life is within 4 hours; is excreted from the cerebrospinal fluid much more slowly, which indicates a high tropism of the product for brain tissue.

Piracetam method of use and dosage:
Inside, intravenously. Parenterally - intravenously, at an initial dose of 10 g; at severe conditions- IV drip, over 20-30 minutes - up to 12 g/day; as a result of improvement, the dose is gradually reduced and switched to oral administration. Orally, at the beginning of treatment - 800 mg in 3 doses, before meals, as the condition improves, the single dose is gradually reduced to 400 mg; Duration of treatment - 6-8 weeks. Daily dose - 30-160 mg/kg, frequency of administration - 2 times a day, if necessary - 3-4 times a day. The duration of treatment ranges from 2-3 weeks to 2-6 months. If necessary, it can be repeated after 6-8 weeks. For long-term therapy of psychoorganic syndrome in the elderly - 1.2-2.4 g/day; loading dose during the first weeks of therapy is up to 4.8 g/day. When treating cerebrovascular disorders in the acute phase, it should be prescribed as early as possible, at a dose of 12 g/day for 2 weeks, and then 4.8-6 g/day. For cortical myoclonus, treatment begins with a dose of 7.2 g/day, after 3-4 days the dose is increased by 4.8 g/day until maximum dose 24 g/day 2-3 times a day, orally or parenterally. Every 6 months the dose should be reduced by 1.2 g every 2 days. When treating dizziness, the dose is 2.4-4.8 g/day in 2-3 doses. For sickle cell anemia, the daily dose is 160 mg/kg, divided into 4 equal portions. During a crisis - up to 300 mg/kg. For alcoholism - 12 g/day during the period of manifestation of ethanol “withdrawal” syndrome; maintenance dose - 2.4 g. During treatment comatose states, in the post-traumatic period, the initial dose is 9-12 g/day, maintenance dose is 2.4 g, course of treatment is 3 weeks. Children are prescribed a dose of 30-50 mg/day. Treatment should be long-term. Oral solution: daily dose - 3.3 g (8 ml of 20% solution or 5 ml of 33% solution) 2 times a day (before breakfast and dinner). Can be added to fruit juice or other drinks. For chronic renal failure with CC 50-79 ml/min, 2/3 of the usual dose is prescribed in 2-3 doses, with CC 30-49 ml/min - 1/3 of the dose in 2 doses, less than 30 ml/min - 1/6 of the usual dose , one-time.

Piracetam contraindications:
The use of piracetam is contraindicated in acute renal failure in children with diabetes and a history of indications of allergic reactions associated with the use of fruit juices, essences, etc. The drug is not recommended for use in children under 1 year of age.

Piracetam side effects:
Mental agitation, motor disinhibition, irritability, imbalance, decreased ability to concentrate, anxiety, sleep disturbances, gastralgia, nausea, vomiting, constipation or diarrhea, decreased appetite, dizziness, headache, extrapyramidal disorders, convulsions, tremor, increased sexual activity, worsening of angina pectoris. Side effects most often observed at doses above 5 g per day.

Use with other medications:
Increases the effectiveness of hormones thyroid gland, antipsychotic drugs (neuroleptics), indirect anticoagulants(against the background of large doses of piracetam), psychostimulants. When prescribed with antipsychotics, it reduces the risk of extrapyramidal disorders.

Release form:
Capsules containing 0.4 g of piracetam in a pack of 60 pieces; tablets of 0.2 g, film-coated (yellow), in a pack of 60 or 120 pcs.; 20% solution in ampoules of 5 ml (1 g of product in 1 ampoule) in a pack of 10 pcs.; Piracetam granules for babies are light pink in color (brownish sediment is allowed), available in a pack of 56 g (2 g of piracetam, 50 g of sugar and fillers) in glass jars.

Overdose:
In case of an overdose, irritability, insomnia, and tremor occur; in elderly patients - exacerbation of heart failure. In this case, it is necessary to reduce the dose of the product.

Storage conditions:
List B. In a dry place, protected from light.

Synonyms:
Nootropil, pyramems, apams, brains, cerebrohan, ceremonies, cyclocettes, zintilan, dinacel, dynagen, encephalux, e yourself, gabazet, gericites, mrapiran, noocephalum, pirates, pyrroxili, squeezers, euvifor, forteralural, non -statrophin, normbreine, but normabrein, but normabrein Rotrop, Norzetam, Stimubral.

Piracetam composition:
Capsules contain 0.4 g of piracetam;
tablets of 0.2 g piracetam;
20% solution in ampoules of 5 ml - 1 g of product in 1 ampoule;
piracetam granules for babies light - 2 g piracetam, 50 g sugar and fillers.

Additionally:
Kidney function indicators should be constantly monitored (especially in patients with chronic renal failure) - residual nitrogen and creatinine, and in patients with liver diseases - functional state liver.
Abrupt discontinuation of the product should be avoided. In patients receiving antiepileptic drugs medicines During PIRACETAM therapy, the main therapy must be continued, since the threshold convulsive readiness may decrease.
In case of sleep disturbances, it is recommended to cancel the evening dose and add this dose to the daytime dose.
Penetrates through the filter membranes of hemodialysis machines.

Manufacturers: Asfarma (Russia), Organika (Russia), Nizhny Novgorod State Enterprise for the production of biological products (Russia), ICN - Marbiofarm (Russia), Dalkhimfarm (Russia), Bryntsalov (Russia), Minskintercaps (Belarus), Akrikhin (Russia), RUE "Belmedproducts" (Belarus).

Attention!
Before using the medication, you should consult your doctor.
The instructions are provided for informational purposes only.