Suspension "Paracetamol for children": instructions for use. Children's Paracetamol in the form of a suspension (syrup): instructions for use, dosage, price, reviews

Currently available in pharmacies big choice medications that help quickly reduce fever and relieve local pain in young children. A popular antipyretic drug is Paracetamol syrup for children. In order to use it correctly and not harm your child’s health, you should know about its main characteristics, features and rules of administration.

Release form medicine for children

The drug "Paracetamol" is available in various types, so young mothers are often faced with the need to choose, which is difficult due to the abundance of its varieties. Consider the fact that many children, especially those under two years of age, will not be able to swallow the drug in tablet form. The medicine must be selected correctly, corresponding to the age group and skills of the child.

Forms of release of the drug:

Form of the drug Active ingredient content Characteristics
Pills 500 / 200 mg Due to the high content of paracetamol in the composition, it is practically not prescribed for the treatment of children. In rare cases, the doctor may recommend taking it at 1/4, 1/8.
Candles 100 / 500 mg Most safe option For child's body, the active substance is absorbed faster than when using the drug in other forms.
Syrup 120 mg / 5 ml The liquid form of the medicine has a pleasant taste and is specially designed for treating children from the first month.
Suspension 24 mg/1 ml Admission is possible in infancy and in newborns, since the calculation of a single dose is made depending on body weight.

The best option is syrup. It looks like a viscous liquid Pink colour. Available in dark glass bottles of 100 and 200 milliliters. The product comes with a special double-sided measuring spoon for correct dosing and instructions for use.

The syrup does not taste strawberry discomfort, so the child will be happy to take it.

Composition and pharmachologic effect syrup

The active ingredient in children's syrup is paracetamol. For 5 ml of the drug its content is 120 mg. In addition to the main component, the following auxiliary ingredients are present:

  • ethanol;
  • glycerol;
  • flavoring;
  • purified water;
  • sorbitol;
  • propylene glycol;
  • propyl parahydroxybenzoate;
  • methyl parahydroxybenzoate.

The medicine has antipyretic and analgesic effects. When using it, you must understand that it is not able to relieve other symptoms of the disease and completely eliminate them, since it does not have an anti-inflammatory effect.

The main effect of the active substance is expressed in blocking the enzyme cyclooxygenase (COX 1, COX 2) and completely stopping the production of prostaglandins. The drug has a direct effect on the central nervous system (CNS), and has a positive effect on thermoregulatory and pain centers.

After entering the body, the medicine has a healing effect for 4 hours. During this time, it is completely absorbed in the intestine and excreted through genitourinary system. Paracetamol has no effect on water-salt balance and the gastrointestinal mucosa, so its use is absolutely safe, provided that the correct dosage is followed.

Indications for use

Paracetamol syrup is widely used in the treatment of neuralgia and myalgia; it is recommended to be taken during pregnancy and lactation. It quickly relieves many types of pain (headache, dental, muscle, etc.) and restores the body's temperature balance, regardless of the etiology and reasons for its increase. The drug helps well with the following pathological phenomena:

  • febrile state due to influenza, ARVI, other infections, etc.;
  • prevention of complications after vaccination;
  • pain syndrome of any severity.

Instructions for using liquid Paracetamol

The drug is taken before meals with a drink big amount water. It is not recommended to dilute it in various drinks, but if the child is small and refuses to take the medicine, it is allowed to add the required volume of syrup to the milk or formula.

Before use, you should thoroughly shake the container with the medicine, then pour a certain amount of liquid into a measuring spoon or draw it into a syringe.

The frequency of use should not exceed 4 times a day at intervals of 4-6 hours. The course of treatment is 3 days; its further use is not advisable. If all initial symptoms persist, you should consult your doctor to adjust your therapy.

The dosage is calculated taking into account the body weight and age of the patient. In no case should you exceed the one-time or daily dose of the medicine consumed. The norms for the use of Paracetamol with an active substance content of 120 mg / 5 ml are shown in the table:

special instructions for use

Typically, symptoms decrease within 15-20 minutes after taking the drug and disappear completely after 40-60 minutes. Increasing the duration of the therapeutic course should be agreed with the pediatrician. When using the drug as a pain reliever, the course of treatment is no more than 5 days and 3 days in the fight against fever.

To achieve quick results, the suspension must be washed down with plenty of water. If this is not done, its action will slow down and the effect will be weak.

Do not use the drug simultaneously with other drugs that contain paracetamol. There is a risk of overdose and side effects. It is also prohibited to independently increase the consumption rate of the suspension - the consequences can be very serious.

The medicine should be used with caution in patients with diabetes mellitus, since it contains sucrose and sorbitol. For children with benign hyperbilirubinemia, disorders of the liver and kidneys, the dosage and duration of treatment is determined by the doctor.

Paracetamol falsifies laboratory tests for content uric acid and glucose in the blood plasma, so it is better to take the prescribed tests after treatment.

Contraindications

Before use, make sure there are no contraindications. These include the following pathologies:

  • inflammatory diseases gastrointestinal tract;
  • intolerance or hypersensitivity to the constituent components (especially paracetamol);
  • renal and liver failure;
  • diseases of the blood system.

Interaction with other tools

Before using the children's suspension, consult your doctor and tell him about the medications your child is taking. The combination of some of them can have a detrimental effect on the body, resulting in the risk of serious diseases and increased side effects.

Group of drugs Possible effect
Ethanol, barbiturates, Rifampicin, Phenylbutazone, Flumecinol, tricyclic antidepressants In case of overdose, there is a risk of hepatotoxic effects on the liver.
Cimetidine Increases the possibility of hepatotoxicity.
Salicylates (alone and in combination with Chloramphenicol) There is a danger of formation cancerous tumors Bladder and kidneys.
Barbiturates Reduce the positive effect of paracetamol.
Ethanol There is a risk of acute pancreatitis.
Nonsteroidal anti-inflammatory drugs There is a high risk of developing renal papillary necrosis and “analgesic” nephropathy.
Diflunisal Plasma concentration of paracetamol increases by 50%.

Overdose symptoms

The drug must be used strictly according to the instructions. Exceeding the daily dosage can lead to severe pathologies (for example, renal failure), and in a severe stage - to death.

If your child drinks more than the recommended amount, contact your doctor, even if he or she is not feeling well. You should also do a gastric lavage and take adsorbents (activated carbon, Polysorb, etc.). Depending on the content of the active substance in the blood, further recommendations a specialist will give it. Instructions for rehabilitation measures will be different.

The main symptoms of overdose include the following:

  • diarrhea;
  • nausea with vomiting;
  • loss of appetite;
  • harsh or nagging pain in the stomach and intestines;
  • increased sweating;
  • decreased body temperature and blood pressure;
  • convulsions, severe vomiting(at acute intoxication organism).

Possible side effects

In this medical product Sorbitol is contained in small quantities (2 g / 120 mg), so in rare cases, intestinal upset and diarrhea occur. Not all children tolerate the medicine; there may be allergies or hypersensitivity to some components.

If after taking the syrup you notice some of the reactions listed below, then you should stop using it in the future. Side effects occur rarely; their appearance is mainly accompanied by intoxication of the body. Side effects:

  • anemia;
  • epigastric spasms;
  • dyspnea;
  • aseptic pyuria;
  • hypersensitivity;
  • toxic epidermal necrolysis;
  • spasms in the bronchi;
  • impaired renal and liver function;
  • hemolytic anemia;
  • hepatonecrosis;
  • allergic reactions on the skin (hives, rash, redness).

Direct analogues of children's Paracetamol are products with the same active ingredient: Panadol Baby, Calpol, Efferalgan. Ibuprofen-based syrups, approved for use from 3 months onwards, can be substitutes for the medicine: children's Nurofen, Ibuprofen-FT, Ibufen.

An increase in temperature in a child indicates the development of an inflammatory process in the body. Perhaps this is due to childhood infections or acute respiratory infections, teething, or a vaccination given the day before. In any case, high fever causes a lot of anxiety for the little patient and throws his parents into panic.

There are many antipyretic drugs on the market today. The most popular among them for many decades remains the time-tested children's Paracetamol in the form of syrup or suspension. If you follow all the recommendations described in the instructions They can bring down the temperature even in babies a few months old. In this review you can learn more about the features of the drug.

Composition and effect of the medicine

Paracetamol-based antipyretics are used throughout the world. The active substance stops the formation of the enzyme (cyclooxygenase), causing an increase temperatures and occurrence pain. The inhibition of this enzyme occurs in the central nervous system. As a result, the fever quickly subsides and the pain goes away. The gastric mucosa is not affected. Blocking of cyclooxygenase in the central nervous system is associated with such a feature of Paracetamol as the lack of anti-inflammatory effect. Therefore, the use of the medicine is pointless for pain caused by inflammatory processes - muscle and joint pain, as well as pain as a result of injury to ligaments and tendons.

Children's Paracetamol should not be taken in parallel with other medications containing paracetamol - otherwise there is a high risk of overdose.

The drug in the form of syrup and suspension can be bought today at any pharmacy. You don't even need a recipe for this. This also indicates the relative safety of the product.

Paracetamol begins to act after 30-40 minutes.

The price of a bottle of suspension with a capacity of 100 ml is 60-80 rubles, a bottle of 200 ml costs about 120-150 rubles. 50 ml of syrup costs about 50 rubles. 100 ml - 80 rubles.

Indications

Paracetamol syrup for children and Paracetamol suspension are forms of the drug created specifically for the youngest patients. The liquid viscous consistency is very convenient for babies to take. And if tablets containing paracetamol are allowed only for children over 12 years of age, then the suspension can be used to save babies who are only a month old from fever (under the supervision of pediatricians and in age-appropriate dosages).

Indications for admission are:

  • elevated body temperature in a child(up to 38.5°C or, as in Lately recommended by pediatric experts, up to 38.9°C);
  • mild or moderate pain: headaches and toothaches, neuralgia, pain during teething.

You can lower your temperature with medications if the thermometer shows 38.5° or higher.

High temperature can be dangerous in itself - for example, it can provoke seizures. In some cases, it is urgent to bring down the temperature - every mother should know about ways to overcome them. And antipyretics are designed to alleviate the condition of patients in such situations.

An important point is that Paracetamol for children does not cure, but only relieves the symptoms of the disease. Heat and pain indicate a leak in the body pathological process. These signs indicate that you need to call a doctor who will examine the baby and prescribe treatment.

Release forms

The medicine is found on pharmacy shelves in different forms:

  • tablets in dosages of 200, 325 and 500 mg;
  • capsules;
  • syrup (120 mg/5 ml and 125 mg/5 ml);
  • suspension (120 mg/5 ml);
  • suppositories (suppositories for adults and children, differing in size and dosage).

Tablets and capsules are usually prescribed to adolescents and adults. The dose is selected by the doctor in accordance with the patient’s health and weight. Children's forms - syrup, suspension and suppositories.

Suppositories are administered rectally and are absorbed in the intestines. The method of use is described in detail in the instructions for the product. The advantages of this drug:

  • absence of sugar, flavorings and dyes, which is especially important for children with allergies;
  • longer-lasting effect compared to other forms of the drug, although it will take longer to wait for the suppositories to take effect;
  • long shelf life - 2 years, and opened syrup can be stored for only a month.

Differences between syrup and suspension

Syrup and suspension are forms of children's Paracetamol that have much in common:

  • identical action;
  • similar consistency;
  • same dosage (5 ml of product contains 120 mg of active substance);
  • pleasant fruity aroma and sweetish taste with a typical bitterness (various flavors are available: raspberry, strawberry, orange);
  • similar containers (bottles or dark glass bottles with a tight-fitting cap, 100 or 200 ml).

The syrup should not be given to children under 2 years of age.

The main differences are observed in the compositions. The suspension does not contain sugar, whereas refined sugar is an ingredient in syrup - parents of diabetic children need to know about this. Besides there is alcohol in the syrup, therefore, it is not suitable for treating children under two years of age.

Dosage

Details about the dosage and features of taking Paracetamol in the form of syrup and suspension can be read in the attached instructions for use (instructions for syrup and suspension). It describes dosages depending on age. But a more significant point is the patient’s weight. If a child at 7 years old weighs only 15-16 kg, then the norm for him will be the dose recommended for the previous age group.

So, age standards Paracetamol syrup intake for children is as follows:

  • 2-6 years - 5-10 ml;
  • 6-12 years - 10-20 ml;
  • teenagers from 12 years old - 20-40 ml.

Suspension dosages:

  • 1-3 months - 2 ml;
  • 3 -12 months - 2.5-5 ml;
  • 1-6 years - 5-10 ml;
  • from 6 years - 10-20 ml.

The recommended amount of paracetamol is 10 mg per 1 kg of body weight. That is, an individual single dose for a child weighing 24 kg is 240 mg of the active substance. 5 ml of syrup or suspension contains 120 mg of paracetamol. Accordingly, the patient needs to take approximately 10 ml of liquid (this is 2 measuring spoons).

Reception features

Measure the liquid using the convenient spoon that comes with the bottle, a cap with markings, or a special syringe. It is recommended to take the product no earlier than an hour or two after meals. Required condition- Take with plenty of water.

The medicine cannot be diluted with water, but it must be washed down.

You should not take the medicine more often than once every 4 hours. Duration of treatment is a maximum of 3-5 days. According to reviews experienced mothers, Paracetamol in the form of syrup and suspension acts in 15-20 minutes, sometimes you have to wait a little longer.

Contraindications

Suspension (and syrup) Paracetamol has a number of contraindications. It is strictly prohibited to take the drug to patients who have serious illnesses kidneys, liver and blood. It is not prescribed to babies under 1 month of age (the age limit for syrup is from 2 years).

As with all other medications, a contraindication to taking the drug is the child’s personal intolerance to some of its components. If, after the baby took the medicine, he showed signs of an allergic reaction (from a banal rash to life-threatening Quincke's edema), it is obvious that the drug is not suitable for him.

Paracetamol should be prescribed with caution to children aged 1-3 months (most often in inpatient conditions), patients with Gilbert's syndrome, diabetics.

Side effects

Paracetamol rarely causes side effects such as:

  • allergies;
  • nausea and vomiting;
  • abdominal pain;
  • heart pain;
  • shortness of breath.

Overdose

Be careful when calculating the dose and store the medicine out of the reach of children to prevent your child from taking the medicine in excess of the required amount.

Follow the dosage and the baby will quickly recover.

Symptoms of overdose appear through:

  • pallor;
  • nausea, vomiting, abdominal pain;
  • increased sweating;
  • pain in the liver (starts after a day or two).

A significant overdose due to the development of acute liver failure can lead to coma and death.

To find out the degree of overdose and adequate treatment, you need to consult a doctor. Pre-medical actions- gastric lavage (effective no later than 4 hours after the incident) and taking activated charcoal.

Analogs

Paracetamol has analogues - Panadol, Efferalgan, Calpol and others. The funds have similar composition and efficiency. But the prices for these drugs vary: naturally, foreign ones are more expensive than domestic ones. The properties are similar to Paracetamol Nise and Nurofen. They contain completely different ingredients. The drugs have a large number of contraindications and side effects, but they provide a pronounced anti-inflammatory effect.

Paracetamol analogue: Panadol - a remedy for fever and pain.

Reviews

Of course, it is always interesting to hear reviews from mothers who have used the medicine in practice.

“My son was 3 months old when his temperature first rose - 39.5°C. This happened after the vaccination. Although the pediatrician warned about possible reaction, I panicked. I called my sister, she immediately came and brought a Paracetamol suspension with her. Using a measuring spoon, I easily measured out the required amount and gave the drug to the child. The fever began to subside within 10-15 minutes. We managed without an ambulance, although I was already close to calling one.”

Marina V.:

“My daughter in kindergarten often gets infected from other children, and the disease is always accompanied by a high temperature. Almost since birth, I have been saving my baby from fever with Paracetamol suspension. I like quick effect and the low cost of the medicine, and my daughter is quite satisfied with its taste.”

“I have three children of different ages. Paracetamol suspension is suitable for a 4-month-old baby, a 5-year-old daughter, and a 10-year-old son. I even drank it a couple of times. Everything is clearly written in the instructions, and I easily calculated the dose for my weight. What I like most is the quick effect and the absence of side effects.”

Summary

Children's Paracetamol - fast-acting remedy from fever and pain. In the form of a suspension in appropriate dosages, the drug can even be used to alleviate the condition of early infancy. Paracetamol has stood the test of time. It is safe and effective if you follow the instructions.

Natalia Roy

An effective anti-inflammatory and antipyretic medicine for acute respiratory viral infections, sore throat, and otitis in a child is “Paracetamol” - a children’s syrup or suspension. The drug is used for fever and pain of any origin in children over 6 months. The drug should be dosed accurately so that treatment does not lead to stomach pain and liver problems.

Release form, composition

Paracetamol is produced for children in the form of thick liquids with a pleasant smell and sweet taste. The color of the syrup is yellowish, the suspension is white-pink. Vials with a volume of 50 m 100 ml are packed in cardboard boxes with drawings and inscriptions confirming that the medicine is intended for children. It is easier for a child to drink a sweet and aromatic liquid than a hard tablet.

Pharmacological action and indications for use

High temperature in children is dangerous for the development of complications of the infectious-inflammatory process and the occurrence of seizures. Paracetamol reduces pain and reduces temperature due to its effect on the functions of the corresponding nerve centers.

Indications:

  • Pain of mild to moderate intensity in the throat, ears, headache, joint, muscle, dental (including teething).
  • Feverish state in diseases of infectious origin.
  • Increase in temperature after vaccination.
  • Pain due to burn or injury.
  • Fever of unknown etiology.
  • Neuralgia.

Medical experts recommend using paracetamol, ibuprofen or combination drugs containing these active ingredients to get rid of feverish syndrome. The medications are antipyretics, non-narcotic analgesics. Paracetamol belongs to the anilides, ibuprofen belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). The effect of paracetamol on the area of ​​inflammation is much weaker than that of ibuprofen and other NSAIDs. However, acetaminophen is less irritating to the gastrointestinal mucosa.

At what age can it be given to children?

"Paracetamol" for children is used to reduce temperature during acute respiratory viral infections and diseases respiratory tract and middle ear, “classic” childhood infections (chickenpox, scarlet fever, rubella, etc.).

Infants are given syrup at temperatures above 38°C. Children over 1 year old take the medicine at t=38.5°C.

How long does it take for an antipyretic to take effect?

The effect of the drug begins to appear, on average, 25 minutes after consuming a dose corresponding to the patient’s age and weight. Acetaminophen reaches maximum concentration in the blood within 30 to 60 minutes after ingestion. The antipyretic effect is maximum during the first 2 hours, then begins to decrease.

Children's syrup "Paracetamol": instructions for use

Shake the liquid contents of the bottle before use. Use a measuring syringe or spoon for more accurate dosing of syrup. Manufacturers place one of the devices inside a cardboard package.

Directions for use and dosage

The syrup/suspension is given to the child between meals, no earlier than 1 to 2 hours before or after meals. The medicine is diluted only if the baby cannot drink the thick liquid. Instructions for use contain detailed information about syrup dosages for children of different ages.

For one appointment:

  • infants 2 - 3 months old with a body weight of 4.5 - 6 kg - as prescribed by the doctor;
  • infants from 3 to 12 months weighing more than 6 kg: 2.5 – 5 ml (0.5 – 1 measuring spoon, m. l.);
  • from 1 year to 5 years: 5 – 10 ml (1 – 2 m. l.);
  • from 5 to 12 years: 10 – 20 ml (2 – 4 m. l.);
  • children weighing more than 60 kg: 20 – 40 ml (4 – 8 m. l.).

The dosage of the syrup requires compliance with the proportion of 10 - 15 mg of active substance per 1 kg of body weight.

Children can take Paracetamol syrup up to 4 times a day. During the day, the child is given no more than 60 mg per 1 kg of body weight.

Special instructions for taking syrup

If a child is sick, parents do not always have the opportunity to go with him to a doctor’s appointment or call a pediatrician at home.

  • Without consulting a doctor, you can give a paracetamol-based drug to an infant over 2 months old once.
  • A child over 3 months old is treated with an antipyretic and analgesic drug for 3 days without a pediatrician’s prescription.
  • Paracetamol syrup is used as an analgesic for various types of pain syndrome for no more than 5 days.
  • You should not give a child an antipyretic in quantities intended for the treatment of adults.
  • Overdose, which is possible when ingesting syrup, rectal suppositories and suspensions with the same active ingredient at the same time, should be avoided.

Drug interactions with other drugs
Antihistamines enhance the therapeutic effects of Paracetamol syrup for children. A child with fever can be given at night along with the antipyretic drug Zyrtec drops or Erius syrup. Antihistamines reduce intoxication of the body and prevent the occurrence of allergic reactions to medications.

The bioavailability of the active ingredient in Paracetamol syrup decreases after taking activated carbon. Phenobarbital and Rifampicin reduce antipyretic effect facilities. Antiepileptic drugs and ethanol increase the rate of formation of metabolites, including those that negatively affect the liver (hepatotoxic).

Contraindications, side effects and overdose

Paracetamol syrup for children is prescribed to the vast majority of young patients with high fever and complaints of pain. However, sweet medicine should not be given to patients with inborn errors of simple carbohydrate metabolism.

Contraindications for taking the drug are:

  • hypersensitivity to the main and/or auxiliary components;
  • severe liver dysfunction;
  • renal failure;
  • age 0 – 2 months;
  • gastritis.

Paracetamol-based drugs are prescribed with caution for severe anemia, leuko- and thrombocytopenia, moderate violations liver function, children aged 2 - 3 months and premature babies. Possible negative effects of the active substance of the syrup: allergic reactions in the form of itchy rashes on the skin, mucous membranes and angioedema(Quincke).

Acute poisoning with the drug in children on the first day is manifested by nausea, stomach pain, and severe sweating. Vomiting and diarrhea may occur. Symptoms of overdose worsen after 24–48 hours: pain in the right hypochondrium and cardiac arrhythmias appear. Most severe consequences- encephalopathy and coma.

You should stop taking the drug immediately and seek medical advice medical care. Cope with moderate symptoms An overdose will be helped by taking intestinal sorbents: Activated carbon, White carboactive, Polyphepan.

Analogs of antipyretic syrup

Drugs with the same active ingredient may have several forms and different trade names. Paracetamol in children's dosage is contained in rectal suppositories"Cefekon D", oral suspensions "Calpol" and "Panadol Baby". The family medicine cabinet must have these medications.

Paracetamol for children begins to act after 30 minutes. The effect of the drug at high temperature The child has enough for 2 – 4 hours. Rectal suppositories "Cefekon D" with the same active substance act faster, reducing the temperature within 15 - 20 minutes.

If a child has a fever or migraine, then syrups and tablets can cause vomiting. In such cases, as well as with gastritis, it is preferable rectal suppositories with paracetamol.

Pediatricians recommend that if a child’s temperature remains above 38.5°C for more than three days, change the antipyretic syrup. Replace Paracetamol children's drug with another active substance. Usually this is a Nurofen suspension for children, which contains ibuprofen (100 mg/5 ml), or rectal suppositories, sold under the same trade name. The effects of ibuprofen last from 6 to 8 hours.

"Paracetamol extra" for children is available in powder form for the preparation of a solution for oral use. In addition to the main substance, 1 sachet contains plant extracts (cat's claw, pyrethrum, potato shoots) that increase therapeutic effect. When combining different active ingredients there is an increase in the therapeutic effect of each and a weakening of possible negative manifestations individual substances in the composition.

The most common medicine for adults and children for fever and pain is Paracetamol. Each of us has probably taken it or heard about it, but not everyone knows how to use it correctly for children.

The drug is used for respiratory and infectious diseases to relieve pain (toothache, headache) and heat (temperature and fever), and is used for burns and injuries. The drug has a partial anti-inflammatory effect.

Manufacturers produce cold remedies various shapes and dosages. Paracetamol in syrup, suspension, suppositories and tablets has been specially developed for the treatment of children. Not all children can swallow tablets whole, so the best option Pediatricians consider using it in syrup or suspension.

Children's suspension - a viscous structure of pink color with strawberry aroma is available in dark bottles of 100 ml and 200 ml in cardboard packs with a measuring spoon or syringe.

The medicinal product contains active and Excipients. Active substance– paracetamol.

Excipients: methyl parahydroxybenzoate, liquid sorbitol, glycerol, xanthan gum, strawberry flavor, azorubine dye, water, sucrose, etc.

The active substance has a blocking effect on the enzyme cyclooxygenase, and therefore stops the synthesis of prostaglandins. The drug has a direct effect on the nervous system, actively affecting thermoregulatory and pain centers.

Thus, it relieves headaches, toothaches, fever, and has an antipyretic effect.

The drug is well absorbed, the maximum activity of the active substance occurs within 6 hours after treatment. The suspension, entering the patient’s body, has a healing effect within four hours and is absorbed in the intestines. With the help of liver enzymes, the metabolic process occurs, then the breakdown products are removed from the body through the urinary system.

Remember! Before use, be sure to carefully read the attached instructions for use of a drug such as Paracetamol for children, suspension.

Can a child be given paracetamol for fever? The drug is indicated to be given to children from one month from birth after a doctor’s prescription: for influenza, colds, infectious diseases (chickenpox, measles, mumps, rubella, scarlet fever), for sore throat, otitis media, neuralgia, burns and injuries, etc.

The suspension is ready for use; it must be shaken for 2-3 minutes before use. Pediatricians recommend giving it to children before meals 3 times a day, washed down with boiled water.

Remember! The interval between doses of the medicine should be at least four hours.

For ease of use and dosing, the cardboard box contains a plastic double-sided spoon. A large spoon is designed for a volume of 5 ml, equal to 120 mg of substance; small - for a volume of 2.5 ml, equal to 60 mg of substance.

The dosage of the product directly depends on the weight and age of the baby. Permissible dose for a single use of the drug is 15 mg/kg body weight. Highest daily dosage– 60 mg/kg based on the patient’s weight.

Taking into account the age and weight of the patient, pediatricians recommend taking the medicine following the dose:

  • age from 1 to 3 months – drink 2 ml liquid preparation= 50 mg;
  • age from 3 to one year - drink from 2.5 to 5 ml of liquid drug = 60 mg - 120 mg;
  • age from one to 6 years - drink from 5 to 10 ml of liquid drug = 120 mg - 240 mg;
  • age from 6 to 14 years - drink from 10 to 20 ml of liquid drug = 240 mg - 480 mg.

Remember! Maximum rate self-treatment no more than three days to achieve an antipyretic effect and no more than five days to relieve pain.

Consultation with a doctor will help you find out the indications for use of the product.

Before using baby syrup, the glass bottle must be shaken. Pediatricians recommend taking syrup before eating 4 times throughout the day.

Taking into account the age and weight of the child, pediatricians recommend taking the medicine as follows:

  • age from 0.5 to 3 years - give from ½ tsp. up to 1 tsp. = from 60 mg – 120 mg of substance;
  • age from 12 months to 3 years - give from 1 tsp. up to 1.5 tsp. = 120 mg – 180 mg of substance;
  • age from 3 to 6 years – 1.5 tsp. – give 2 tsp. = 120 mg – 240 mg of substance;
  • age from 12 years - give from 3 tsp. up to 5 tsp. = 360 mg – 600 mg of substance.

It is very difficult for babies to swallow the tablet; many mothers crush the drug and mix it with water. Doctors recommend taking the tablets to children starting from the age of two.

Dosage of 200 mg of drug No. 10 in tablets:

  • Ages from 2 to 6 years – ½ tablet 3-4 times within 24 hours;
  • Ages from 6 to 12 years – 1 tablet 4 times within 24 hours;
  • Ages over 12 years – 1-2 tablets within 24 hours.

Remember! The maximum course of self-treatment is no more than three days to achieve an antipyretic effect and no more than five days to relieve pain. Further use of the product is recommended only after consultation with a specialist.

Can I give children's Paracetamol with Analgin to a child?

Analgin - no narcotic, related to the type of analgesics. It goes well with Paracetamol.

Taking these drugs together is indicated at a very high, persistent temperature, when antipyretic drugs do not cope.

The combination of these funds can only be used once (as a last resort), and cannot be used systematically! When dosing medications, be sure to take into account the child’s body weight and age, and be sure to consult a doctor.

Application this tool cannot be used if present:

  • diseases of the digestive system - erosion, ulcers, bleeding, etc.;
  • allergy to the components included in the drug;
  • kidney diseases, progressive pathologies;
  • liver diseases, chronic form.

The drug is also prohibited for children under one month of birth, during the rehabilitation period, and in the third trimester of pregnancy.

Very rarely the following may occur:

  • ulcers on the body that will cause itching and burning;
  • swelling of the mucous membranes and face;
  • allergic reactions: urticaria, rash, swelling.

When treated with Paracetamol, side effects may occur:

  • in case of malfunctions of the nervous system - insomnia, mood swings, dizziness, aggression;
  • in case of cardiac dysfunction - increased blood pressure, attacks of tachycardia;
  • in case of gastrointestinal disorders - vomiting, stool upset, nausea, abdominal pain, dry mouth.
  • for problems with the urinary system - renal colic, jade.

If you notice any side effects, stop using the medicine immediately and consult your doctor.

After conducting the study, scientists identified positive and negative characteristics.

Positive:

  • decrease in the patient’s body temperature;
  • withdrawal pain symptoms: fever, intoxication, headache, toothache, etc.;
  • recovery without subsequent complications;

Negative

  • allergic reactions - rashes on the dermis of the body, accompanied by itching and burning;
  • nausea,
  • vomit;
  • diarrhea;
  • exacerbation of chronic diseases.

In the fight against colds, the use of Paracetamol for children in suspension is indicated. Active ingredients, included in its composition, will quickly relieve unpleasant symptoms diseases and in a short time you will feel an improvement in the baby’s condition, but you must follow the dosage.

Attention! The information is provided for informational purposes only. This instruction should not be used as a guide to self-medication. The need for prescription, methods and doses of the drug are determined exclusively by the attending physician.

general characteristics

international and chemical names: paracetamol; N-(4-hydroxyphenyl)acetamide;
basic physicochemical characteristics: transparent viscous liquid of pink color with a sweet taste and characteristic aroma of raspberries;
compound: 5 ml of syrup contains 120 mg of paracetamol;
Excipients: propylene glycol, glycerin, ethyl alcohol 96%, sorbitol, methyl parahydroxybenzoate, propyl parahydroxybenzoate, Raspberry food flavoring, Ponceau 4R, purified water.

Release form. Syrup.

Pharmacotherapeutic group

Analgesics and antipyretics (Antipyretics- medicines that reduce body temperature during fever). ATC code N02B E01.

Pharmacological properties

Pharmacodynamics. Possesses analgesic (Analgesic- pain reliever, analgesic), antipyretic and weak anti-inflammatory effects. The mechanism of action is associated with inhibition of prostaglandin synthesis and an effect on the thermoregulation center in the hypothalamus.

Pharmacokinetics. After oral administration, paracetamol is rapidly absorbed from the gastrointestinal tract, mainly in small intestine, mainly by passive transport. After a single dose of 500 mg, the maximum concentration in plasma (Plasma- the liquid part of the blood that contains shaped elements(erythrocytes, leukocytes, platelets). Changes in the composition of blood plasma are used to diagnose various diseases(rheumatism, diabetes etc.). Prepared from blood plasma medications) blood level is reached after 10-60 minutes and is about 6 μg/ml, then gradually decreases and after 6 hours it is 11-12 μg/ml. Well distributed in tissues and mainly in body fluids, with the exception of adipose tissue and cerebrospinal fluid. Linking with proteins (Squirrels- natural high molecular weight organic compounds. Proteins play an extremely important role: they are the basis of the life process, participate in the construction of cells and tissues, are biocatalysts (enzymes), hormones, respiratory pigments (hemoglobins), protective substances (immunoglobulins), etc.) is less than 10% and increases slightly with increasing dose. Sulfate and glucuronide metabolites do not bind to plasma proteins even at relatively high concentrations. Paracetamol is metabolized primarily in the liver by conjugation with glucuronides, conjugation with sulfate and oxidation with the participation of mixed liver oxidases and cytochrome P450. Hydroxylated metabolite with a negative effect -N-acetyl-p-benzoquinoneimine, which is formed in a very small quantities in the liver and kidneys under the influence of mixed oxidases and is usually detoxified by binding to glutathione, can accumulate during an overdose of paracetamol and cause tissue damage. In adults, most of paracetamol is bound to glucuronic acid and in smaller quantities to sulfuric acid. These conjugated metabolites do not have biological activity. In premature babies, newborns and in the first year of life, the sulfate metabolite predominates. Half-life (Half-life(T1/2, synonymous with half-elimination period) - the period of time during which the concentration of a drug in the blood plasma decreases by 50% from the initial level. Information about this pharmacokinetic indicator is necessary to prevent the creation of a toxic or, conversely, ineffective level (concentration) of the drug in the blood when determining the intervals between administrations) is 1-3 hours. In patients with liver cirrhosis, the half-life is slightly longer. Renal clearance (Clearance(purification, purification) - a pharmacokinetic parameter reflecting the rate of purification of the blood plasma from the drug and denoted by the symbol C1) paracetamol is 5%. The drug is excreted in the urine mainly in the form of glucuronide and sulfate conjugates. Less than 5% is excreted as unchanged paracetamol.

Indications for use

Pain syndrome (Pain syndrome- a painful subjective feeling that appears due to the impact on the body of super-strong or destructive stimuli. There are pain syndromes of the head, face, mouth, back, etc.) low and medium intensity of various origins (head and toothache, neuralgia, muscle pain; pain during teething; for injuries; burns; pharyngitis (Pharyngitis- inflammation of the pharyngeal mucosa), rheumatic pains). Fever (Fever– a special reaction of the body that accompanies many diseases and is manifested by an increase in body temperature. A febrile reaction most often occurs in infectious diseases when administered medicinal serums and vaccines, for traumatic injuries, tissue crushing, etc.) with infectious inflammatory diseases.

Directions for use and doses

The drug is prescribed orally. Single dose for children aged 6 months to 1 year – 60 – 120 mg of paracetamol (1/2 - 1 teaspoon of syrup), from 1 year to 3 years – 120 – 180 mg of paracetamol (1 -1.5 teaspoon spoons of syrup), from 3 to 6 years - 180 - 240 mg of paracetamol (1.5 - 2 teaspoons of syrup), from 6 to 12 years - 240 - 360 mg of paracetamol (2 - 3 teaspoons of syrup), over 12 years - 360 - 600 mg of paracetamol (3 - 5 teaspoons of syrup). The frequency of administration is 3-4 times a day with an interval between each dose of at least 4 hours. The maximum duration of treatment is 3 days.

Side effect

Nausea and epigastric pain may occur; allergic reactions ( skin rash, itching (Itching– a modified feeling of pain caused by irritation of nerve endings pain receptors) , hives (Hives- a disease characterized by the formation of limited or widespread itchy blisters on the skin and mucous membranes), Quincke's edema (Quincke's edema- (angioedema), acute limited paroxysmal swelling of tissues - the body’s reaction to an allergen. Externally, Quincke's edema manifests itself as sharply limited swelling of tissues (mainly lips, eyelids, cheeks), sometimes skin rashes at the site of swelling, usually without itching or pain)). Possible side effects, How hemolytic anemia (Hemolytic anemia– anemia caused by increased hemolysis (destruction of red blood cells), which occurs due to a defect in the structure of red blood cell membranes), thrombocytopenic purpura (Thrombocytopenic Purpura- a common disease of humans (as well as animals) from the group of hemorrhagic diathesis. Caused by a decrease in the number of platelets in the blood and a violation of its coagulation), methemoglobinemia (Methemoglobinemia– increased (over 1%) content of methemoglobin in erythrocytes peripheral blood. Congenital forms caused by abnormalities in the structure of the hemoglobin molecule or sharp decline some enzymes in red blood cells. Acquired forms occur upon contact with chemicals or drug poisoning), agranulocytosis (Agranulocytosis– a pathological syndrome in which the number of granulocytes in the peripheral blood sharply decreases or they are completely absent). At long-term use in doses exceeding therapeutic ones, hepatotoxic effects are possible.

Contraindications

Hypersensitivity to paracetamol and other components of the drug, severe dysfunction of the liver and kidneys, deficiency of glucose-6-phosphate dehydrogenase, blood diseases (severe anemia (Anemia- a group of diseases characterized by a decrease in red blood cells or hemoglobin in the blood), leukopenia (Leukopenia- the content of leukocytes in the peripheral blood is less than 4000 in 1 μl, due to the influence of various damaging factors on the body)), children up to 6 months of age. Congenital hyperbilirubinemia (Gilbert, Dubin-Johnson, Rotor syndrome).

Overdose

When taking syrup in doses higher than recommended, the following side effects are possible: hemolytic anemia, thrombocytopenic purpura; methemoglobinemia, agranulocytosis, hepatotoxic effect. In this case, gastric lavage is necessary, if possible, early administration antidote (Antidotes- medicines used to treat poisoning in order to neutralize the poison and eliminate the pathological disorders caused by it)– acetylcysteine.

Features of application

Use with caution to treat patients with impaired liver and kidney function, with benign hyperbilirubinemia. Long-term use anticonvulsants causes an increase in liver activity enzymes (Enzymes- specific proteins that can significantly accelerate chemical reactions, occurring in the body without being part of the final reaction products, i.e. are biological catalysts. Each type of enzyme catalyzes the transformation of certain substances (substrates), sometimes only a single substance in a single direction. Therefore, numerous biochemical reactions carries out a huge number of different enzymes in cells. Enzyme preparations widely used in medicine), which enhances the intensity of the “first pass” effect through the liver and prolongs the clearance of the drug. This may prevent paracetamol blood levels from reaching therapeutic levels. With long-term use of the drug, monitoring of the peripheral blood picture and the functional state of the liver is necessary.

Interaction with other drugs

In patients taking phenytoin, rifampicin, barbiturates and tricyclics antidepressants (Antidepressants- products that improve mood, relieve anxiety and tension, and increase mental activity. Used to treat depression), it is possible to increase the half-life of paracetamol and increase the risk of hepatotoxicity. Increases the effect of indirect anticoagulants (Anticoagulants- drugs that reduce blood clotting). Strengthens toxicity (Toxicity- the ability of some chemical compounds and substances of biological nature to provide harmful effect on the human body, animals and plants) chloramphenicol.

General Product Information

Conditions and shelf life. Store out of reach of children, protected from light at a temperature not exceeding 25°C.

Best before date. 3 years. After opening the bottle, the shelf life of the drug is 30 days at a temperature of 20-25°C.

Vacation conditions. Over the counter.

Package. 50 ml or 100 ml in a glass bottle, 1 bottle in a pack; 50 ml or 100 ml in a polymer bottle, 1 bottle in a pack; 100 ml in a glass or polymer jar, 1 jar in a pack.

Manufacturer.CJSC Scientific and Production Center "Borshchagovsky Chemical and Pharmaceutical Plant".

Location. 03680, Ukraine, Kiev, st. Mira, 17.

Website. www.bhfz.com.ua

Preparations with similar active ingredients

  • Paracetamol - "Darnitsa"
  • Paracetamol - "Arterium"

This material is presented in free form on the basis of the official instructions for medical use of the drug.

Pharmgroup:

Analgesic non-narcotic drug.

Pharmaceutical action:

Non-narcotic analgesic, blocks COX1 and COX2 mainly in the central nervous system, affecting the centers of pain and thermoregulation.
IN inflamed tissues cellular peroxidases neutralize the effect of paracetamol on COX, which explains the almost complete absence of anti-inflammatory effect.
The absence of a blocking effect on the synthesis of Pg in peripheral tissues determines the absence of negative influence on water-salt metabolism(retention of Na+ and water) and the mucous membrane of the gastrointestinal tract.

Pharmacokinetics:

Absorption - high, TCmax - 0.5-2 h; Cmax - 5-20 µg/ml. Communication with plasma proteins - 15%. Penetrates through the BBB. Less than 1% of the dose of paracetamol taken by a nursing mother passes into breast milk.
Metabolized in the liver in three main ways: conjugation with glucuronides, conjugation with sulfates, oxidation by microsomal liver enzymes. IN the latter case toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine ​​and mercapturic acid. The main cytochrome P450 isoenzymes for this metabolic pathway are the CYP2E1 isoenzyme (mainly), CYP1A2 and CYP3A4 (minor role). With glutathione deficiency, these metabolites can cause damage and necrosis of hepatocytes.
Additional metabolic pathways include hydroxylation to 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates.
In adults, glucuronidation predominates, in newborns (including premature babies) and small children - sulfation. Conjugated metabolites of paracetamol (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity.
T1/2 - 1-4 hours. Excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged. In elderly patients, drug clearance decreases and T1/2 increases.

Indications:

Feverish syndrome in the background infectious diseases;
pain syndrome (mild and moderate severity): arthralgia, myalgia, neuralgia, migraine, dental and headache, algodismenorrhea.

Contraindications:

Hypersensitivity, neonatal period (up to 1 month).
Carefully. Renal and liver failure, benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcohol impairment liver, alcoholism, diabetes mellitus (for syrup),
pregnancy, lactation period, elderly age, early infancy (up to 3 months).

Dosage:

Orally, with plenty of liquid, 1-2 hours after eating (taking immediately after eating leads to a delay in the onset of action).
For adults and adolescents over 12 years of age (body weight over 40 kg), a single dose is 500 mg; the maximum single dose is 1 g. The frequency of administration is up to 4 times a day. Maximum daily dose- 4 g; The maximum duration of treatment is 5-7 days.
Children: maximum daily dose for children up to 6 months (up to 7 kg) - 350 mg, from 6 months to 1 year (up to 10 kg) - 500 mg, 1-3 years (up to 15 kg) - 750 mg, 3-6 years (up to 22 kg) - 1 g, 6-9 years (up to 30 kg) - 1.5 g, 9-12 years (up to 40 kg) - 2 g.
In the form of a suspension: children 6-12 years old - 10-20 ml (5 ml - 120 mg), 1-6 years old - 5-10 ml, 3-12 months - 2.5-5 ml. The dose for children aged 1 to 3 months is determined individually. Frequency of appointment - 4 times a day; the interval between each dose is at least 4 hours.
The maximum duration of treatment without consulting a doctor is 3 days (when taken as an antipyretic drug) and 5 days (as an analgesic).
Rectally. Adults - 500 mg 1-4 times a day; maximum single dose - 1 g; maximum daily dose - 4 g.
Children 12-15 years old - 250-300 mg 3-4 times a day; 8-12 years - 250-300 mg 3 times a day; 6-8 years - 250-300 mg 2-3 times a day; 4-6 years - 150 mg 3-4 times a day; 2-4 years - 150 mg 2-3 times a day; 1-2 years - 80 mg 3-4 times a day; from 6 months to 1 year - 80 mg 2-3 times a day; from 3 months to 6 months - 80 mg 2 times a day.

Side effect:

Allergic reactions(including skin rash, itching, angioedema).
Rarely - hematopoietic disorders (anemia, thrombocytopenia, methemoglobinemia).

Overdose:

Symptoms: during the first 24 hours after administration - pallor skin, nausea, vomiting, anorexia, abdominal pain; impaired glucose metabolism, metabolic acidosis. Symptoms of liver dysfunction may appear 12-48 hours after an overdose.
In case of severe overdose - liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis.
A hepatotoxic effect in adults occurs when taking 10 g or more.
Treatment: administration of SH-group donors and precursors for the synthesis of glutathione - methionine within 8-9 hours after an overdose and acetylcysteine ​​- within 8 hours. The need for additional therapeutic measures (further administration of methionine, intravenous administration of acetylcysteine) is determined depending on the the concentration of paracetamol in the blood, as well as the time elapsed after its administration.

Interaction:

Reduces the effectiveness of uricosuric drugs.
Concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs (decreased synthesis of procoagulant factors in the liver).
Inducers of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications even with a small overdose.
Long-term use of barbiturates reduces the effectiveness of paracetamol.
Ethanol contributes to the development of acute pancreatitis.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity.
Long-term combined use of paracetamol and other NSAIDs increases the risk of developing “analgesic” nephropathy and renal papillary necrosis, the onset of terminal stage renal failure.
Simultaneous long-term administration of paracetamol in high doses and salicylates increases the risk of developing kidney or bladder cancer.
Diflunisal increases the plasma concentration of paracetamol by 50% - the risk of developing hepatotoxicity.
Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.
Special instructions: If the febrile syndrome continues during the use of paracetamol for more than 3 days and pain syndrome more than 5 days, consultation with a doctor is required.
The risk of developing liver damage increases in patients with alcoholic illness liver.
Distorts laboratory test results when quantification glucose and uric acid in plasma.
During long-term treatment monitoring of the peripheral blood picture and the functional state of the liver is necessary.
Simultaneous use not recommended with ethanol.
The syrup contains 0.06 XE of sucrose per 5 ml, which should be taken into account when treating patients with diabetes.

Is a medicine. A doctor's consultation is required.

Composition and release form

1 tablet contains paracetamol 200 or 500 mg; in contour-free packaging or in a blister 6 or 10 pcs.

100 ml syrup - 2.4 g; in bottles of 50 ml.

pharmachologic effect

pharmachologic effect- antipyretic, analgesic.

Inhibits cyclooxygenase, inhibits PG biosynthesis in the central nervous system. Reduces the excitability of the thermal center, increases heat transfer.

Pharmacokinetics

Quickly and almost completely absorbed into the gastrointestinal tract. Penetrates the placental barrier and is found in breast milk. Metabolized in the liver. It is excreted mainly in urine in the form of conjugates. The maximum effect develops within 2 hours.

Indications for the drug Paracetamol syrup 2.4%

Pain and fever syndromes.

Contraindications

Hypersensitivity, renal dysfunction.

Side effects

Allergic reactions.

Interaction

Atropine and other antispasmodics delay absorption, while metoclopramide accelerates it. Cholesterol and activated carbon reduce bioavailability. Barbiturates, antiepileptic drugs, rifampicin and ethyl alcohol increase the rate of biotransformation and the formation of metabolites, incl. hepatotoxic.

Directions for use and doses

Orally, adults - 200-500 mg 2-3 times a day; children 6-12 months - 25-50 mg 2-3 times a day, up to 5 years - 100-150 mg, up to 12 years - 150-250 mg 2-3 times a day.

Storage conditions for the drug Paracetamol syrup 2.4%

In a dry place, protected from light, at a temperature not lower than 18 °C (do not freeze).

Keep out of the reach of children.

Shelf life of the drug Paracetamol syrup 2.4%

tablets 500 mg - 3 years.

syrup 2.4% - 2 years.

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Category ICD-10Synonyms of diseases according to ICD-10
G43 MigraineMigraine pain
Hemicrania
Hemiplegic migraine
Migraine headache
Migraine
Migraine attack
Serial headache
K13.7 Others and unspecified lesions oral mucosaAspirin burn of the oral mucosa
Sore gums when wearing dentures
Oral inflammation
Inflammation of the oral mucosa
Inflammation of the oral mucosa after radiation therapy
Inflammation of the oral mucosa after chemotherapy
Inflammation of the oral mucosa
Inflammation of the mucous membranes of the oral cavity
Inflammatory diseases of the oral cavity
Inflammatory process of the pharynx
Disease of the oral mucosa
Radioepithelitis
Irritation from dentures
Irritation of the oral mucosa by dentures and braces
Oral wounds
Sores from wearing dentures
Injuries to the oral cavity and larynx
Injuries to the oral mucosa
Trophic diseases of the oral mucosa
Trophic diseases of the oral mucosa
Erosive and ulcerative periodontal lesions
Erosive and ulcerative lesions of the oral mucosa
Erosive and ulcerative periodontal lesions
Erosive and ulcerative lesions of the oral mucosa
Erosion of the oral mucosa
M79.1 MyalgiaPain syndrome in muscular and joint diseases
Pain syndrome in chronic inflammatory diseases of the musculoskeletal system
Pain in the muscles
Muscle soreness
Muscle soreness during heavy physical activity
Painful conditions of the musculoskeletal system
Pain in the musculoskeletal system
Muscle pain
Pain at rest
Muscle pain
Muscle pain
Musculoskeletal pain
Myalgia
Myofascial pain syndromes
Muscle pain
Muscle pain at rest
Muscle pain
Muscle pain of non-rheumatic origin
Muscle pain of rheumatic origin
Acute muscle pain
Rheumatic pain
Rheumatic pains
Myofascial syndrome
Fibromyalgia
M79.2 Neuralgia and neuritis, unspecified
Brachialgia
Occipital and intercostal neuralgia
Neuralgia
Neuralgic pain
Neuralgia
Neuralgia of the intercostal nerves
Neuralgia of the posterior tibial nerve
Neuritis
Traumatic neuritis
Neuritis
Neurological pain syndromes
Neurological contractures with spasms
Acute neuritis
Peripheral neuritis
Post-traumatic neuralgia
Severe neurogenic pain
Chronic neuritis
Essential neuralgia
R50 Fever of unknown originHyperthermia malignant
Malignant hyperthermia
R51 HeadacheHead pain
Pain due to sinusitis
Pain in the back of the head
Headache
Headache of vasomotor origin
Headache of vasomotor origin
Headache with vasomotor disturbances
Headache
Neurological headache
Serial headache
Cephalgia
R52.2 Other persistent painPain syndrome of non-rheumatic origin
Pain syndrome with vertebrogenic lesions
Pain syndrome with neuralgia
Pain syndrome from burns
Pain syndrome is mild or moderate
Neuropathic pain
Neuropathic pain
Perioperative pain
Moderate to severe pain
Moderate or mild pain syndrome
Moderate to severe pain syndrome
Ear pain due to otitis media
T30 Thermal and chemical burns of unspecified locationPain syndrome from burns
Pain from burns
Pain from burns
Slow healing post-burn wounds
Deep burns with wet eschar
Deep burns with profuse separation
Deep burn
Laser burn
Burn
Burn of the rectum and perineum
Burn with slight exudation
Burn disease
Burn injury
Superficial burn
Superficial burn of 1st and 2nd degree
Superficial skin burns
Post-burn trophic ulcer and wound
Post-burn complication
Fluid loss from burns
Burn sepsis
Thermal burns
Thermal skin lesions
Thermal burn
Trophic post-burn ulcers
Chemical burn
Surgical burn

Paracetamol for children: instructions for use and reviews

Latin name: Paracetamol children

ATX code: N02BE01

Active substance: Paracetamol

Manufacturer: Rozfarm LLC, Pharmstandard-Leksredstva, Biokhimik, Pharmproekt, Dalkhimfarm, Irbitsky chemical farm plant, Farmapol-Volga, Mega Pharm (Russia), Anqiu Lu An Pharmaceutical Co. (China), LLC Pharmaceutical Company "Zdorovye" (Ukraine)

Updating the description and photo: 19.10.2018

Paracetamol for children is a non-narcotic analgesic.

Release form and composition

Dosage form of release - suspension for oral administration: homogeneous, pink in color, with a characteristic fruity odor (100 and 200 ml in polymer bottles, or bottles made of orange glass, or glass, or polyethylene terephthalate for medicines, sealed with a polymer screw cap with first opening control or “push-turn” system, 1 bottle in a cardboard box without/with a measuring cup or measuring spoon).

Composition of 100 ml suspension:

  • active substance: paracetamol – 2.4 g;
  • additional components: sodium nipasept (sodium ethyl parahydroxybenzoate, sodium methyl parahydroxybenzoate and sodium propyl parahydroxybenzoate) – 0.15 g, maltitol – 80 g, malic acid – 0.05 g, non-crystallizing sorbitol 70% – 1.33 g, xanthan gum – 0.6 G, lemon acid anhydrous – 0.02 g, azorubine dye – 0.001 g, strawberry or orange flavoring – 0.1 g, water – up to 100 ml.

Pharmacological properties

Pharmacodynamics

Paracetamol is a medicinal substance that has antipyretic and analgesic effects. It has virtually no anti-inflammatory properties.

The mechanism of action is due to the ability to block cyclooxygenase in the central nervous system, affecting the centers of thermoregulation and pain.

The drug has virtually no anti-inflammatory properties. It does not affect water-electrolyte metabolism and the condition of the gastrointestinal mucosa (GIT), since it has a very small effect on the synthesis of prostaglandins in peripheral tissues.

Pharmacokinetics

Paracetamol is characterized by high absorption; it is quickly and almost completely absorbed from the gastrointestinal tract. Binds to plasma proteins by 10–25%. The maximum plasma concentration is reached after 30–120 minutes and is 5–20 mcg/ml.

The drug penetrates the blood-brain barrier. Less than 1% passes into mother's breast milk dose taken. The distribution of the substance in body fluids is relatively even.

Paracetamol is metabolized primarily in the liver in three main ways, such as oxidation by microsomal liver enzymes, conjugation with sulfates and conjugation with glucuronides. During oxidation, intermediate toxic metabolites are formed, which are subsequently conjugated first with glutathione, then with mercapturic acid and cysteine. For this method metabolism, the main isoenzymes of the cytochrome P 450 system are CYP2E1 (mainly), CYP1A2 and CYP3A4 (minor role). If there is a deficiency of glutathione in the body, these metabolites can cause damage and necrosis of hepatocytes. Additional metabolic pathways are methoxylation to 3-methoxyparacetamol and hydroxylation to 3-hydroxyparacetamol, which are subsequently conjugated to sulfates or glucuronides.

In children under 10 years of age, the main metabolite of the drug is paracetamol sulfate, in children over 12 years of age - conjugated glucuronide.

Conjugated metabolites of paracetamol (conjugates with glutathione, sulfates, glucuronides) are characterized by low pharmacological activity, including toxic.

When taking a therapeutic dose, the total clearance is 18 l/h, the half-life (T ½) is from 1 to 4 hours. When taking therapeutic doses, 90–100% of the taken dose of paracetamol is excreted in the urine within 24 hours. The main amount of the drug after conjugation is released in the liver in the form of glucuronide (60–80%) and sulfate (20–30%). About 5% of the dose is excreted unchanged.

In elderly patients, paracetamol clearance decreases and T ½ increases.

In patients with severe renal failure (creatinine clearance 10–30 ml/minute), the elimination of paracetamol is slowed down, the rate of elimination of sulfate and glucuronide is lower than in healthy individuals.

Indications for use

Paracetamol suspension for children is prescribed to children aged 3 months to 12 years in the following cases:

  • increased body temperature due to influenza, colds and childhood infectious diseases such as scarlet fever, chicken pox, measles, mumps, etc.;
  • toothache, including during teething or tooth extraction, Ear ache with otitis media, headache, sore throat.

Contraindications

  • fructose intolerance;
  • severe impairment of renal or hepatic function;
  • age less than 2 months;
  • simultaneous use of other drugs containing paracetamol;
  • hypersensitivity to any component of the drug.

Carefully:

  • liver dysfunction, including Gilbert's syndrome;
  • viral hepatitis;
  • genetic absence of the enzyme glucose-6-phosphate dehydrogenase;
  • renal dysfunction (creatinine clearance< 30 мл/мин);
  • anorexia/bulimia;
  • dehydration;
  • hypovolemia;
  • severe blood diseases (leukopenia, severe anemia, thrombocytopenia);
  • diabetes;
  • chronic alcoholism.

Instructions for use of Paracetamol for children: method and dosage

Paracetamol suspension for children should be taken orally, preferably 1-2 hours after meals, with plenty of liquid. Immediately before use, the bottle should be shaken well. For correct dosing, a measuring spoon or cup is usually included in the package.

The optimal dose is determined taking into account the age and body weight of the child.

For children over 3 months of age, a single dose of paracetamol is 10–15 mg/kg, dosing frequency is 3-4 times a day. The highest daily dose should not exceed 60 mg/kg.

The drug can be taken in 1 dose at intervals of 4–6 hours, but no more than 4 times during the day.

  • 2–3 months (4.5–6 kg): the drug can be used only as prescribed by a doctor*;
  • 3–6 months (6–8 kg): 4 ml (96 mg)/16 ml (384 mg);
  • 6–12 months (8–10 kg): 5 ml (120 mg)/20 ml (480 mg);
  • 1–2 years (10–13 kg): 7 ml (168 mg)/28 ml (672 mg);
  • 2–3 years (13–15 kg): 9 ml (216 mg)/36 ml (864 mg);
  • 3–6 years (15–21 kg): 10 ml (240 mg)/40 ml (960 mg);
  • 6–9 years (21–29 kg): 14 ml (336 mg)/56 ml (1344 mg);
  • 9–12 years (29–42 kg): 20 ml (480 mg)/80 ml (1920 mg).

Unless otherwise prescribed by your doctor, you can use the drug for no more than 3 days.

* A single dosage of Paracetamol for children 2-3 months old is 10-15 mg/kg with a dosage frequency of 1-2 times a day. If the temperature does not decrease after taking the second dose, you should consult a doctor. For other indications, the drug can be given to children 2–3 months old only as prescribed by a pediatrician.

Children with impaired renal function need to increase the interval between doses. When creatinine clearance (CC) is 10–50 ml/minute, it should be at least 6 hours;< 10 мл/минуту – 8 часов.

Side effects

Grouping of adverse events by frequency (according to post-registration data): very often - ≥ 1/10, often - from ≥ 1/100 to< 1/10, нечасто – от ≥ 1/1000 до < 1/100, редко – от ≥ 1/10 000 до < 1/1000, очень редко – < 1/10 000, неизвестно – установить частоту на основе имеющихся данных не представляется возможным.

Paracetamol may cause the following side effects:

  • from the gastrointestinal tract: rarely - nausea, abdominal pain, diarrhea, vomiting;
  • from the blood and lymphatic system: rarely - thrombocytopenia, anemia, leukopenia;
  • from the liver and biliary tract: very rarely - impaired liver function; with long-term use in large doses – nephrotoxic and hepatotoxic effects;
  • from the outside immune system: very rarely - Quincke's edema, anaphylaxis;
  • from the outside respiratory system: very rarely hypersensitivity To acetylsalicylic acid or intolerance to other non-steroidal anti-inflammatory drugs (NSAIDs) - bronchospasm;
  • from the skin and subcutaneous tissues: very rarely - skin reactions hypersensitivity, including skin rash, urticaria, skin itching, Lyell's syndrome (toxic epidermal necrolysis), acute generalized exanthematous pustulosis, Stevens-Johnson syndrome.

Overdose

In case of overdose, there is a risk of developing intoxication, especially in patients receiving concomitant inducers of microsomal liver enzymes, in persons with malnutrition, patients with liver diseases and children. As a result, cholestatic hepatitis, liver failure, cytolytic hepatitis, fulminant hepatitis, sometimes with death, may occur.

Symptoms of acute poisoning: pale skin, stomach pain, nausea, vomiting, anorexia, metabolic acidosis, impaired glucose metabolism (sweating, dizziness, loss of consciousness). After 1-3 days, signs of liver damage appear (pain in the liver area, decreased prothrombin levels, increased bilirubin concentrations and liver enzyme activity), which reach a maximum on days 3-4. In the case of an adult receiving paracetamol at a dose of 10,000 mg/kg and children receiving 125 mg/kg of paracetamol, cytolysis of hepatitis occurs with the development of encephalopathy, metabolic acidosis, complete and irreversible liver necrosis, liver failure - serious complications which can lead to coma and death.

In case of severe overdose, progressive encephalopathy, liver failure, coma, and death occur. Acute renal failure with tubular necrosis without severe liver damage may also develop. Her characteristic features are lumbar pain, proteinuria, hematuria, as well as pancreatitis and arrhythmia.

In case of long-term use of the drug in doses exceeding the recommended ones, hepatotoxic and nephrotoxic effects may develop: nonspecific bacteriuria, renal colic, interstitial nephritis and papillary necrosis.

In case of overdose, you should stop taking paracetamol, if possible, do a gastric lavage, take an enterosorbent (activated carbon or polyphepane) and immediately consult a doctor. Treatment is predominantly symptomatic. At maximum short term after an overdose, it is necessary to determine the content of paracetamol in the blood plasma. In case of poisoning, SH-group donors, acetylcysteine ​​and methionine (precursors for glutathione synthesis) must be administered within the first 10 hours. The need for additional therapeutic measures (including further administration of methionine and acetylcysteine) is determined by the doctor depending on the level of paracetamol in the blood and the time that has passed since its administration. Liver tests are performed at the beginning of treatment and every 24 hours thereafter. Liver enzymes return to normal within 1-2 weeks in most cases. Severe overdose may require a liver transplant.

If a child accidentally takes the drug on his own, he should immediately seek medical help, even if he feels well. 24 hours after taking paracetamol in case of serious violations liver treatment is carried out jointly with specialists specialized department hepatology or poison control center.

special instructions

To avoid overdose during treatment with this drug, you should not take other drugs containing paracetamol at the same time.

Children 2-3 months old can be given the drug only as prescribed by a pediatrician.

If a patient is diagnosed with glutathione deficiency, caution must be exercised as there is an increased risk of overdose. In addition, in patients with low level glutathione, in particular in very malnourished people with anorexia, patients with low index body weight and people suffering chronic alcoholism, there are known cases of liver failure. Also in some cases, for example, with sepsis, paracetamol increased the risk of developing metabolic acidosis.

The drug may distort laboratory test results for glucose and uric acid levels in the blood.

If it is necessary to use the drug for more than 5 days, it is recommended to monitor peripheral blood parameters and functional state liver.

If there is no effect within 3 days of taking the medicine, you should consult your doctor.

Impact on the ability to drive vehicles and complex mechanisms

Paracetamol has no effect on the speed of reactions and the ability to concentrate.

Use during pregnancy and lactation

There are no negative effects of paracetamol when used during pregnancy and lactation. The drug penetrates the placental barrier and is excreted from breast milk(no more than 0.23% of the dose taken by the mother). IN experimental studies Neither teratogenic, nor embryotoxic, nor mutagenic effects of the substance have been established. However, paracetamol is prescribed to pregnant and breastfeeding women only after assessing the expected benefits and potential risks.

There are no data on the effect on fertility.

Use in childhood

According to the instructions, Paracetamol for children is strictly contraindicated in children under 2 months. At the age of 2 to 3 months, it can be used once to reduce elevated temperature bodies after vaccination. From the age of 3 months, it is used according to the dosage regimen specified in the instructions.

For impaired renal function

Paracetamol should be used with caution in patients with impaired renal function.

In addition, it is necessary to increase the interval between doses: with CC 10–50 ml/minute - up to 6 hours, with CC< 10 мл/минуту – до 8 часов.

For liver dysfunction

Patients with impaired liver function Paracetamol should be used with caution.

Use in old age

In old age, drugs containing paracetamol should be used under close medical supervision.

Drug interactions

Caution should be used if necessary joint use drugs-inducers of microsomal liver enzymes, such as ethanol, barbiturates, phenylbutazone, anticoagulants, rifampicin, tricyclic antidepressants, zidovudine, isoniazid, anticonvulsants, amoxicillin + clavulanic acid.

Preparations of St. John's wort, butadione and flumecinol increase the production of hydroxylated active metabolites, as a result of which in case of overdose (taking 5000 mg or more), the risk of developing severe liver damage increases.

Paracetamol increases the elimination time of chloramphenicol by 5 times, which increases the likelihood of poisoning. Reduces the effectiveness of uricosuric drugs.

Paracetamol, taken in a daily dose of 4000 mg for 4 or more days, can enhance the effect when administered simultaneously indirect anticoagulants Therefore, the International Normalized Ratio should be monitored during and after taking this combination. If paracetamol is taken irregularly, it does not have a significant effect on the effect of anticoagulants.

With long-term simultaneous use of other NSAIDs, the risk of developing renal papillary necrosis, “analgesic” nephropathy and end-stage renal failure increases.

Alcohol consumed during treatment with paracetamol contributes to the development of acute pancreatitis.

Simultaneous long-term use paracetamol in high doses in combination with salicylates increases the risk of developing bladder or kidney cancer.

Possible medicinal effects other drugs for paracetamol:

  • probenecid reduces its clearance by almost 2 times due to inhibition of the process of its conjugation with glucuronic acid;
  • domperidone and metoclopramide increase the rate of its absorption;
  • cholestyramine reduces the rate of its absorption;
  • Long-term use of barbiturates reduces its effectiveness;
  • diflunisal increases its plasma concentration by 2 times, as a result of which the risk of developing hepatotoxicity increases;
  • phenytoin reduces its effect and increases the risk of hepatotoxicity;
  • myelotoxic drugs enhance the manifestations of its hematotoxicity.

Inhibitors of microsomal oxidation (including cimetidine), when used simultaneously, reduce the risk of hepatotoxicity.

Analogs

Analogues of Paracetamol for children are: Paracetamol (suspension), Calpol, Daleron, Children's Panadol.

Terms and conditions of storage

Shelf life – 3 years.

Storage conditions: protected from light, out of reach of children, temperature up to 25 °C.