Papaverine: instructions for use, indications during pregnancy, dosage. Papaverine suppositories: purpose, composition, instructions for use and contraindications Papaverine rectal suppositories instructions for use

The negative symptoms caused by spasms are well known to everyone. Abdominal pain, headache and even hypertension are quite dangerous conditions. It is especially bad if blood vessels undergo spasms. Doctors have long wanted to get a drug that would effectively protect the patient’s body from spasms. Such a remedy actually exists - these are the well-known Papaverine candles.

Description

This is an antispasmodic drug that can help with a variety of diseases. The mass distribution of the product is due to its high efficiency and safety for the affected organism. It is the second property that causes the drug to be often prescribed to pregnant women to relieve spasms of internal organs.

Composition and release form

Papaverine suppositories can be bought in pharmacies without a prescription; it is produced by various pharmaceutical companies. In Russian pharmacies the drug is available from Belarusian and Russian manufacturers.

Three dosage forms can be found on sale, each of which differs in its purpose, namely: tablets, rectal suppositories and injection solution.

Rectal papaverine suppositories are white to yellowish-white or creamy-white, torpedo-shaped.

One suppository contains 20 mg of papaverine hydrochloride.

In addition to the active ingredient, candles contain stearins and solid fats that melt at human body temperature, and emulsifiers.

Features of pharmacokinetics

Papaverine suppositories have different absorption rates, depending on their shape. On average it is slightly more than 54%. The medicine is perfectly distributed in all tissues of the human body. The half-life ranges from half an hour to two hours. Its metabolism occurs in the liver and is excreted by the kidneys. It can be removed from the body using hemodialysis.

Effect of the medication

According to the instructions for the Papaverine suppositories, the main purpose of the prescribed suppositories is to relieve spasms of smooth muscles and dilate blood vessels. The drug has a calming effect and allows you to quickly reduce the sharply increased blood pressure. Additionally, suppositories stimulate blood flow to the affected organ and help restore the patient’s normal heart rhythm.

Doctors note the positive effect of the medication on the smooth muscles of the respiratory, urinary and intimate organs, as well as the gastrointestinal tract. Papaverine hydrochloride, which is the active component, additionally eliminates pain and cramps. Made in the form of suppositories, the drug is easy to use.

The rectal administration of Papaverine suppositories allows the active ingredient to be absorbed into the blood, due to which it is delivered to the diseased organ at high speed. This is what ensures the increased effectiveness of the medicine and almost instantaneous relief of the patient’s condition.

The effect of suppositories lasts from 3.5 to 4 hours. Then the active component is destroyed and leaves the body along with urine.

What Papaverine suppositories are used for is interesting to many.

Purpose

In the classification of medications, Papaverine usually falls into two categories - antispasmodics and vasodilators (vasodilators).

The drug can be prescribed for various spasms of internal organs, which relate to the circulatory, urinary systems and gastrointestinal tract. First of all, these are spasms of the smooth muscles of the internal organs. These organs are: uterus, intestines, gall bladder, bladder, respiratory organs.

In addition, the drug is able to eliminate spasms of blood vessels in the heart, brain, and peripheral vessels.

Areas of medicine in which the product is used:

• therapy;
• urology;
• surgery;
• gynecology;
• gastroenterology;
• traumatology.

Main indications for the use of suppositories:

• inflammatory process in the gallbladder (cholecystitis);
• uterine hypertonicity;
• inflammatory process of the large intestine (colitis);
• haemorrhoids;
• inflammation of the bile ducts (cholangitis);
• headache;
• constipation;
• hypertension;
• flatulence;
• intestinal and stomach colic;
• menstrual pain;
• bronchospasm;
• urethritis;
• angina pectoris;
• cystitis;
• endarteritis;
• urolithiasis disease;
• pylorospasm;
• renal colic;
• spasms of cerebral vessels;
• pyelitis;
• spasms of the ureter that retain urine;
• spasms of the bile excretion pathways.

The drug can be used as the only remedy to eliminate certain symptoms, and as part of a complex treatment.

In addition, the drug is often used as a method of premedication before various surgical operations and procedures on the organs of the gastrointestinal tract, in the urological and proctological field. The use of “Papaverine” allows you to relax the muscles of the internal organs and thereby facilitates surgical manipulations.

The drug for subarachnoid hemorrhage is used for the coronary arteries as a vasodilator. It can also be used for a similar purpose in the process of coronary artery bypass grafting.

"Papaverine", like other antispasmodics, is used as one of the means of complex treatment of erectile dysfunction.

If there is no improvement after a therapeutic course, you should consult a doctor for advice.

What else does the instructions for use for Papaverine suppositories tell us?

Contraindications

Although in most cases the use of suppositories is completely safe for the human body, there are a number of contraindications to the use of the product:

Papaverine suppositories are not prescribed to children under six months of age. Also, the drug is not recommended for use by older people, which is associated with age-related changes in the body. If pathologies of the thyroid gland, endocrinological disorders associated with insufficient production of hormones by the adrenal glands have been identified, in case of traumatic brain injuries, rectal suppositories are prescribed especially carefully so as not to harm the patient’s body.

Instructions for use of Papaverine suppositories for children and adults

Suppositories are intended for rectal administration. If necessary, the candle can be cut into pieces.

• for patients under five years of age - a quarter of a suppository (5 mg) twice a day;
• from five to ten - half a suppository (10 mg) twice a day;
• from ten to eighteen - 20 mg twice a day;
• adults - 2-3 times a day, 1-2 suppositories.

Application for children

The high safety of the drug is evidenced by the fact that it can be given to children from the age of six months. In some cases, a pediatrician may prescribe the drug at a younger age, but most doctors do not welcome this practice.

Most often, “Papaverine” is prescribed to children to eliminate cramping abdominal pain, intestinal colic and bronchospasms, spasms and colic of the liver, urethra, and pancreatitis. There is also the option of using “Papaverine” in pediatrics to combat peripheral vascular spasm during hyperthermia. The antispasmodic is given to the child twenty minutes before the antipyretic.

Side effects

As the instructions for use indicate, suppositories with papaverine hydrochloride are usually well tolerated by patients, and side effects are observed infrequently. As a rule, this happens when the dosage of the drug is slightly exceeded. Side symptoms disappear either when the drug is discontinued or when the dosage is reduced.

When using Papaverine, the following side effects may occur:

• decreased blood pressure;
• angioedema;
• ventricular extrasystole;
• hyperemia;
• constipation;
• hives;
• drowsiness;
• rash;
• tachycardia;
• nausea;
• eosinophilia;
• intestinal bloating;
• cardiac conduction disturbance (atrioventricular block);
• loss of appetite;
• arrhythmias (tachycardia, ventricular extrasystole);
• stomach pain;
• collapse;
• dry mouth;
• hyperthermia (mainly in elderly patients);
• diarrhea;
• sweating;
• dizziness;
• diplopia, blurred vision;
• jaundice.

If allergic symptoms appear, the medication should be stopped immediately. Since the side effects of Papaverine include decreased blood pressure and dizziness, during treatment you should refrain from performing work that requires concentration and attention, or driving.

Overdose of this drug

In accordance with the instructions for papaverine suppositories, overdose is rare in clinical practice. Most often, the drug is used in too large doses to treat children.

The main symptoms of an overdose are the side effects described above, but in a more severe form. The most commonly observed symptoms are:

• double vision;
• weakness;
• decreased blood pressure;
• drowsiness.

Treatment is symptomatic. The patient must be brought to a medical facility. He needs to rinse his stomach, take enterosorbents and drugs that increase blood pressure. In severe cases, hemodialysis (cleansing the kidneys of fluid and toxins) may be performed.

Injection:

• papaverine hydrochloride — 20 mg per 1 ml of medicinal liquid;
• D,L-methionine;
• disodium edetate;
• water for injections.

Pills:

• papaverine hydrochloride — 10 mg in 1 tablet;
• rafinated sugar;
• potato starch;
• stearic acid;
• talc.

Rectal suppositories:

• papaverine hydrochloride - 0.02 g in 1 candle weighing 1.25 g;
• emulsifier No. 1;
• cosmetic stearin;
• hard fat.

Release form

• Papaverine tablets 0.01 g or 0.04 g, depending on the target audience of patients (the first are used in pediatric practice after 6 months), which are packaged in contoured blisters of 10 pieces. The oral form has a slightly bitter taste, is white in color and has no odor at all.
• Solution for injection 2% in ampoules of 2 ml. A cardboard package usually contains 10 pieces and instructions for use of the pharmaceutical drug.
• Rectal suppositories or suppositories for insertion into the rectum, 0.02 g each; secured in blisters of PVC or aluminum foil, 10 pieces each. A plate with the medicine and an annotation are placed in a cardboard box.

pharmachologic effect

Papaverine hydrochloride (Wikipedia indicates that the INN of the drug corresponds to the name of the main active component) - this is opium alkaloid , affecting smooth muscle elements and causing them to relax, therefore the pharmacological group of the drug is determined as myotropic antispasmodics .

The mechanism of the therapeutic action of the biological substance is to influence the secondary messengers (messengers) of the transmission of muscle excitation. Papaverine inhibits PDE (phosphodiesterase), due to which it accumulates in the cell cAMP (cycloadenosine monophosphate) and the ion content decreases calcium , in response to such biochemical changes, the smooth muscles of the internal organs (digestive tube, respiratory and genitourinary systems and vascular bed) relax, their tone decreases .

Pharmacopoeia is a set of mandatory rules and official regulations that guide the manufacture, testing, storage and prescription of medicines to patients. Since the main biologically active component of a pharmaceutical drug is potent, in relation to Papaverine hydrochloride the pharmacopoeia includes the following points for determining the authenticity of a chemical substance:

• physical characteristics– white crystalline powder, odorless, with a slightly bitter taste.
• Solubility– dissolves in water within 40 hours, is slightly soluble in 95% alcohol, soluble in chloroform and practically insoluble in ether.
• Acidity 2% solution of Papaverine hydrochloride – 3.0-4.5 (determined potentiometrically).
• Chemical authentication control– 0.05 g of the pharmaceutical preparation is placed in a porcelain bowl, moistened with a couple of drops of high concentration nitric acid, after which a yellow color should appear, which when heated in a water bath changes to orange.
• Presence of organic impurities– dissolution and color change test in 5 ml concentrated sulfuric acid.

Pharmacodynamics and pharmacokinetics

The active component is quickly and almost completely absorbed by any route of administration of the drug into the body. Once in the bloodstream, it binds to plasma proteins (90% of the total biologically active substance), due to which it easily passes through histohematic barriers. It undergoes biotransformation in the liver. The half-life ranges from 30 minutes to 2 hours, depending on the auxiliary components of the pharmaceutical drug. It is excreted primarily by the kidneys in the form of metabolic products.

Indications for use of Papaverine

• smooth muscle spasm abdominal organs (especially often with , spastic or pylorospasm );
• hypertensive crisis (in combined conservative therapy);
• endarteritis ;
• spasm of the peripheral vascular bed;
• decrease in the lumen of blood vessels in the brain due to contraction of the muscular layer of the arteries;
• bronchospasm ;
• reduction of arterial renal inflow of vascular origin;
• urinary retention due to spasm of the urinary tract.

Indications for use also include the stage premedication before surgical interventions in the abdominal cavity, proctological and urological manipulations. What it is used for – relaxation of smooth muscle elements (for more details, see paragraph “Pharmacological action”).

Contraindications

• intolerance to the constituent components of the drug;
• intracardiac conduction disorders, especially atrioventricular block ;
• hypersensitivity to a pharmaceutical drug;
• heavy liver failure ;
• old age (as there is a significant risk of developing hyperthermic syndrome);
• children up to 6 months of age.

Additional restrictions for use (it is recommended to use only under the constant supervision of qualified medical professionals and regular diagnostic examinations):

• recent traumatic brain injury in the anamnesis;
• chronic;
• states of shock;
• supraventricular ;
• benign ;
• insufficiency of adrenal gland functionality.

Side effects

• From the outside cardiovascular system and blood: atrioventricular block , ventricular tachycardia , decrease .
• From the outside gastrointestinal tract: nausea , constipation (),bloating , impaired passage through the digestive tube, increased activity of hepatic transaminases.
• Other: , , eosinophilia .

Instructions for use of Papaverine (Method and dosage)

Papaverine tablets, instructions for use

In tablets, the pharmaceutical drug can be prescribed to both adults and children, even the frequency of administration does not change and is 3-4 times a day. The dosage of the oral form of the drug depends on the age category of the patient; the following treatment regimen is used:

• from 6 months to 2 years – 0.005 g per dose;
• 3-4 years – 0.005-0.01 g;
• 5-6 years – 0.01 g;
• 7-9 years – 0.01-0.015 g;
• 10-14 years – 0.015-0.02 g;
• adults – 0.04-0.08 g per dose.

Papaverine suppositories, instructions for use

is an extremely unpleasant proctological disease that is associated with , inflammatory processes and pathological expansion of hemorrhoidal veins surrounding the lumen of the rectal outlet. This nosological unit is characterized typical clinical picture , which includes impaired bowel movements, itching, bleeding from the anus. Suppositories with Papaverine will help ease the course of the disease.

The active components of the pharmaceutical drug allow you to relax smooth muscle elements of the intestine , which facilitates the process of bowel movements, because the lumen of the rectum increases slightly. For the same reason, bleeding is stopped, since hard feces do not injure inflamed hemorrhoids, therefore suppositories with Papaverine for hemorrhoids are a kind of “magic wand”.

In pharmacy kiosks you can find suppositories with different dosages of biologically active substances. The course of conservative treatment should begin with 0.02 g, gradually increasing it to 0.04 g if a smaller amount of the pharmaceutical drug does not have its therapeutic effect. It is not recommended to use more than 3 suppositories per day, this is fraught with the development of adverse side effects and even an overdose, since all incoming medications are extremely well absorbed in the rectal area.

How to use Papaverine Hydrochloride injection solution?

The active component of the pharmaceutical drug has high bioavailability, therefore injections can be done both subcutaneously and intramuscularly, as well as intravenously, the therapeutic capabilities of the drug will not be affected, and the final result will be just as strong. However, it should be determined that the instructions for use recommend subcutaneous injections of Papaverine hydrochloride not into the distal part of the forearm, but into the shoulder or the outer surface of the thigh, since the frequency of administration can cause the appearance of a hematoma. Intramuscular injections of Papaverine can be carried out according to the standard scheme, that is, using the upper lateral quadrant of the buttock.

Before making intravenous injections, the amount of pharmaceutical drug prescribed by the doctor should be diluted with 10-20 ml of isotonic solution sodium chloride . It should also be remembered that Papaverine hydrochloride should be administered very slowly, so as not to cause discomfort in the patient during the injection process.

As a rule, the contents of 1 ampoule (2 ml) of a 2% solution of Papaverine Hydrochloride are injected subcutaneously.

Dosage of solution in ampoules for intravenous and intramuscular administration:

• adults: one-time – 0.1 g, daily – 0.3;
• children from 6 months to 1 year: one-time – 0.005 g, daily – 0.01 g;
• at the age of 2 years: one-time – 0.01 g, daily – 0.02 g;
• 3-4 years: one-time – 0.015 g, daily – 0.03 g;
• 5-6 years: one-time – 0.02 g, daily – 0.04 g;
• 7-9 years: one-time – 0.03 g, daily 0.06 g;
• 10-14 years: one-time – 0.06-0.06 g, daily – 0.1-0.2 g.

Dibazol with Papaverine - how to use?

- This antihypertensive medicine from the group of peripheral vasodilators , that is, the active components of the pharmaceutical drug have a vasodilating effect and significantly contribute to lowering blood pressure. Papaverine has similar therapeutic properties in relation to the vascular system, therefore the combination of these drugs is actively used by emergency medical workers to eliminate hypertensive crisis .

Dibazol with Papaverine is administered intramuscularly or intravenously, because in this way the necessary pharmacological effects of the active ingredients develop much faster than with oral or any other method of use. The relaxing effect of biologically active components can be combined with physiotherapeutic methods, for example, a horizontal position with the leg end down, warm foot baths, massage of the lower extremities, and so on.

The dosage of Dibazol with Papaverine to eliminate a hypertensive crisis is 3-5 ml of a 1% solution of Dibazol and 2 ml (contents of 1 ampoule) of a 2% solution of the second pharmaceutical drug. Such a large number of active ingredients can not only reduce blood pressure, but also relieve nausea, pain in the heart and some other manifestations of cardiovascular pathology.

Overdose

Possible symptoms when active ingredients of the drug:

• diplopia (double vision) ;
• weakness;
• lowering blood pressure ;
• increased fatigue .

Specific pharmaceutical no, that's why it applies detoxification therapy And symptomatic treatment . Gastric lavage or the use of sorbents ( milk , , for example) in the first hours after taking oral forms of Papaverine hydrochloride. Also, in case of drug overdose, it is important to constantly monitor and, if necessary, artificially maintain blood pressure.

Interaction

is an antispasmodic, vasodilating, sedative, that is, its pharmacological properties are close to Papaverine. Medicines differ only in the mechanisms of therapeutic action, because Platyfillin with Papaverine are used in combined conservative treatment of spastic syndromes, hypertensive crises and other pathological conditions.

They interact well with Papaverine, as well as Platiphylline, exerting a synergistic therapeutic effect on the smooth muscle elements of the human body. This combination of pharmaceuticals is especially common in obstetric and gynecological hospitals when there is uterine tone, the threat of spontaneous miscarriage, or excessively active early labor.

In medical publications on neurological topics there is news that the effectiveness of Levodopa significantly decreases in combined conservative therapy, from which Papaverine in tablets or in the form of an injection solution against the background of medicinal sanitation use is contraindicated.

Simultaneous use of Papaverine with anticholinergic drugs may manifest itself in enhancing the therapeutic effects of the latter, therefore, if their combined use is necessary, dosage reduction or temporary withdrawal of pharmaceutical drugs should be discussed with a qualified specialist.

Terms of sale

The pharmaceutical drug has been known since time immemorial and has always been famous for the power of its therapeutic effect, which is why previously a prescription in Latin was required at pharmacy kiosks when purchasing it. Nowadays, the procedure for purchasing Papaverine has become much easier, but it is the patient’s responsibility to present a correctly completed and certified prescription by the attending physician.

Storage conditions

In a dry place, protected from direct sunlight, at a temperature not exceeding 25 degrees Celsius in a tightly packed container. The pharmaceutical drug belongs to list B, so its storage should be carefully monitored.

Best before date

special instructions

Papaverine hydrochloride significantly improves peripheral blood circulation, which improves trophic processes in individual organs when used locally. This therapeutic ability determines the use of the pharmaceutical drug in bodybuilding . Practical observations of athletes show that it is most effective to use the drug to increase the specific mass of the deltoid and biceps muscles.

The goal of athletes is to have a local effect on a certain part of the muscle, from which injections are given intramuscularly. The optimal dosage is 1-2 injections per week, given 15-20 minutes before intense training. Further, at the very beginning of physical exercise, all efforts should be aimed at the “enriched” muscle, that is, exercise using the “pumping” (blood pumping) system, since the therapeutic effect of Papaverine when used topically is short-lived.

The ingenuity and resourcefulness of the female half of humanity is in no way behind the stronger sex, because Papaverine hydrochloride is used even in cosmetic procedures and home skin care. Thanks to increased blood circulation in the peripheral parts of the body under the influence of the pharmaceutical drug, the removal of accumulated fluid is improved, swelling is relieved and metabolic processes are stimulated to some extent. Such therapeutic effects allow the drug to be used to combat cellulite , eliminating the unpleasant “orange peel” in the buttocks and back of the thigh, and even getting rid of a couple of extra pounds.

To obtain this result, leading cosmetologists recommend using caffeine and papaverine wrap which can be carried out even at home. To prepare the miraculous mixture, you will need 2 ampoules of Caffeine benzoate, 2 ml each, 2 ampoules of Papaverine hydrochloride, 2 ml each, and a small amount of uncandied honey. Before applying a cosmetic product, you should prepare the skin by using light peeling, scrub or a small local massage.

The mixture should be applied evenly over the entire area of ​​the surface to be treated in a small layer. The cosmetic product will not be absorbed immediately, so it is necessary to tightly cover the skin with plastic wrap (cling film is ideal for this purpose) and insulate yourself by wrapping yourself in a cotton blanket or using winter clothes. It is recommended to carry out the wrap for at least an hour, after which rinse off the remaining mixture with warm water and apply a moisturizing or nourishing cream. The duration of the course is twelve procedures, and the frequency of their implementation is every other day.

The active components of a pharmaceutical drug extend their beneficial effects not only to people, but also to animals, which is why Papaverine has found wide use in veterinary practice . The drug is especially often used for cats, since pets are admitted to hospitals due to spasms of intestinal smooth muscles. The etiological factor is the hygiene procedures of cats, because in the process of “washing”, as a rule, a certain amount of hair is ingested. Papaverine facilitates the passage of the contents of the digestive tube.

Analogs

Papaverine analogues are a variety of pharmaceutical forms of the drug in which it is found on pharmacy shelves. As a rule, one of the forms is not suitable for the patient and then another should be selected. You can also replace these products, but you should first consult with a qualified specialist in this field, because the basic principle of medicine “do no harm” can easily be violated due to ignorance.

A pharmaceutical drug with an international non-proprietary name has a similar antispasmodic effect , which is known to a wide audience under the name . It can also be used for pregnant women, for patients in proctology or urology hospitals, for children in pediatric practice, and for the treatment of headaches at home.

For children

Papaverine hydrochloride is actively used in pediatric practice, starting from the age of 6 months.

Papaverine during pregnancy and lactation

What are Papaverine suppositories used for during pregnancy?

The uterus, the organ of the female reproductive system in which the intrauterine phase of fetal development directly occurs, contains both striated muscles and smooth muscles. In the process of bearing a child, increased tone of this organ often develops, as a result of which spastic pain is possible, early contractions , premature rupture of amniotic fluid and birth not on the planned date. Papaverine hydrochloride has a relaxing effect, which allows you to relieve the above-mentioned manifestations of uterine hypertonicity.

Of course, before using the drug, you should decide on a pharmaceutical form that will have the maximum beneficial effects and will not harm the developing body of the child and mother. For pregnant women, the advisability of using one or another form of Papaverine is determined duration of gestation , for example, in the early stages it is recommended to use oral tablets, and in the later stages intramuscular and subcutaneous administration of injection solutions works much better.

Suppositories with Papaverine during pregnancy

First of all, you should decide on a completely logical question for patients - where to insert Papaverine suppositories during pregnancy, because, as a rule, this pharmaceutical form of the drug is used rectally , however, therapeutic effects are required not in the final sections of the gastrointestinal tract, but in the muscular elements of the genitourinary system. This misconception is typical of women who are completely unfamiliar with the principle of operation of local pharmaceutical suppositories.

After the administration of Papaverine, the active components of the suppositories are actively absorbed and distributed first local blood flow through nearby organs, due to which the smooth muscle elements of the uterus are fully supplied with biologically active substances. Another positive aspect of using this pharmaceutical form is the high bioavailability of rectal suppositories, that is, a large percentage of the drug enters the microcirculatory system and is not excreted. out.

Injections during pregnancy

Of course, the most effective way to use Papaverine hydrochloride is its intramuscular or even intravenous administration, because in this way bioavailability the drug tends to reach its maximum, and the concentration of the active substance remains at its highest point for the longest period of time.
It should be emphasized that the injection form of the pharmaceutical drug is especially relevant in late pregnancy, when uterine hypertonicity or spastic, cramping pain can lead to premature onset of labor and discharge of amniotic fluid. If there are appropriate indications from the attending physician, it is worth considering inpatient treatment, because in this case the pregnant woman will be under the constant supervision of medical personnel, which cannot but inspire confidence.

The dosage of the solution for injection, as well as the frequency of use of the pharmaceutical drug, is selected individually; as a rule, it ranges from 1 to 10 ml of 2% drug 2-4 times a day. If adverse consequences of conservative treatment occur, you should immediately contact a qualified specialist.

Papaverine Hydrochloride tablets, instructions for pregnancy

Since injecting a pharmaceutical drug requires special medical knowledge and skills, and rectal suppositories can cause certain inconvenience and discomfort during their use, these pharmaceutical forms of Papaverine are often replaced with tablets that are prescribed orally. Of course, the effectiveness of such conservative therapy is somewhat lower than that of other ways of introducing the active ingredient into the body, but in terms of everyday use, the tablets have no equal.

Papaverine hydrochloride in oral form is used exclusively for indications, and the criterion for its use is the subjective well-being of the pregnant woman, therefore there is no strict dosage of the pharmaceutical drug. Specialists in obstetrics and gynecology do not recommend taking more than 4 tablets per day, which should be used 2 hours before meals in order to increase the pharmacokinetic abilities of the active ingredient.

Today, papaverine is available in different forms, as well as in a variety of combinations of various drugs. Suppositories, tablets, injections, tablets for children. Each form of release has its own advantages and allows to influence the human body to a certain extent.

The description of papaverine gives us the opportunity to understand that this drug has a hypotensive effect. In addition, it allows you to reduce tone and relax the smooth muscles of almost all internal organs and blood vessels. Please note that in significant doses the drug has the ability to increase the excitability of the heart muscle. Used in the treatment of the central nervous system, although the effect is negligible

Indications

The drug is used in the treatment of certain and central nervous system, in complex therapy. Papaverine instructions have a clear description of indications and contraindications; it is for this reason that the patient can actually immediately understand the possibilities of using this drug. It should be noted that there are no specific contraindications; however, before prescribing the drug, you should definitely consult a doctor.

Application and dosage

The drug is prescribed for certain smooth muscle spasms. As a rule, with diseases of the abdominal cavity, such as:

• spastic colitis,
• cholecystitis,
• pylorospasm.

Papverine is also used for peripheral vascular diseases:

• constriction of heart vessels,
• angina pectoris
• spasms of cerebral vessels.

In complex therapy, papaverine has found very significant use; for bronchitis and other respiratory diseases, papaverine is often prescribed as a unique assistant for remediation.

In order for papaverine to have the maximum effect, the dosage must be precise enough for the effect to actually be significant.

• Adults can take no more than 60 mg orally 3-4 times a day. The daily dose is no more than 0.6 grams.
• Children are prescribed the drug only with the permission of a doctor, from six months to 2 years, no more than 5 mg per day. This drug should be administered very slowly, then the effect of its use will be more significant.

pharmachologic effect

By using this drug, spasm of all smooth muscles can be reduced. As a rule, the action of papaverine reduces sensitivity to colic. Allows you to naturally dilate blood vessels. Thus, a person begins to feel more comfortable and healthy. For endarteritis, this drug can reduce the risk of vasoconstriction. In addition, papaverine has a positive effect on the functioning of blood vessels in the brain and heart.

Instructions for use

Papaverine, the instructions for use of which are quite simple, has become a very popular remedy in the treatment and prevention of many diseases. However, the drug should be prescribed only under the watchful supervision of doctors. It is then that you can be fully confident in the correct and positive effect.

For uterine hypertonicity, papaverine is used. The action of this drug allows the uterus to return to its normal state and prevents the risk of certain defects during the birth process. The drug papaverine is prescribed quite often during pregnancy. This drug has no side effects on the fetus, and accordingly allows you to get the maximum effect from the therapeutic and preventive process.

Papaverine hydrochloride is used very often during pregnancy. As a rule, with the help of this drug the uterus is brought to normal tone. In addition, the use of the medicine allows you to positively prepare the blood vessels for certain stresses during childbirth.

Papaverine is prescribed to children quite often. Since this drug has a minimal number of disadvantages, it is able to provide the maximum number of opportunities for correct and rational treatment.

The popularity of the drug is quite significant. Many domestic companies are engaged in its production, which is why papaverine has very affordable prices. It can be purchased at any pharmacy without a special doctor's prescription.

Papaverine hydrochloride instructions

Papaverine hydrochloride has all the actions of the drug papaverine described above. An additional amount of binding elements allows this drug to be absorbed more intensively, which means that the effect of such use will be quite rapid.

This drug is used almost everywhere for a variety of diseases. As a rule, papaverine is used to relieve spasms in abdominal diseases. The drug also has a very significant number of effects on the blood vessels of the whole body. It is for this reason that it is often prescribed as an additional drug in complex therapy. Papaverine hydrochloride instructions allow you to quickly understand all the nuances of using this drug.

Today, papaverine tablets have become very popular in various fields of medicine. This drug has unique effects on the body, and the combination with a simple release form allows the dosage form to be used for outpatient treatment.

Candles

Suppositories with papaverine are a unique myotropic antispasmodic. The convenient shape of the candles allows you to quickly influence the body in case of urgent need. If you have difficulties using other forms of papaverine, it is best to opt for candles. However, the use must be determined by a doctor, who also establishes clear dosages.

Instructions

Using candles is not difficult. It is for this reason that papaverine suppositories, the instructions for which are quite simple, are popular for self-medication. This drug has a certain analgesic effect on certain organs. Rectal use allows the drug to begin to act very quickly and localize the source of pain.

As a rule, suppositories are prescribed for certain renal colic, as well as spasms of cerebral vessels, colitis and angina pectoris, and even cholecystitis. Papaverine suppositories have a very wide range of applications. And depending on the form and severity of the disease, this particular form of release of the drug can be used.

Candles during pregnancy

The instructions for use state that the use of suppositories with papaverine during pregnancy is not recommended. However, many years of experience in using this drug have shown that there are simply no negative factors affecting the drug’s effect on the fetus. It is for this reason that doctors often, even with colic in the abdomen of a pregnant woman, prescribe this particular type of treatment.

Papaverine suppositories, the price of which is actually considered very affordable, allow you to quickly achieve the desired result. The popularity of the drug is quite significant, and it can be purchased without any problems in almost any pharmacy. A prescription is not needed to purchase the drug.

Papaverine hydrochloride suppositories have a certain amount of additional medicinal bases, which allows this drug to obtain a more intense effect on the necessary areas of pain.

Pricks and injections

Papaverine injections are used much more often than all other pharmacological forms. A convenient method of administration and a quick effect on the body allow doctors to quickly achieve the desired effect. Today, this drug is often combined with similar drugs, which allows you to dilate blood vessels and quickly get rid of pain.

Papaverine injections are practically painless. However, it is through the slow and necessary intake that very unpleasant sensations can arise.

The combination of dibazole with papaverine for high blood pressure

The combination of dibazole with papaverine is prescribed quite often. As a rule, this composition allows you not only to get rid of a certain excruciating pain, but also to begin treatment of the vascular system or other organs. Most often, papaverine with dibazole injections are used to relieve a hypertensive crisis. In this case, dibazole with papaverine quickly and reliably reduces blood pressure.

Papaverine is an effective antispasmodic that is widely used in medical practice for various diseases. Papaverine suppositories are used for pathologies accompanied by spasm of the smooth muscles of hollow organs, for example, cholecystitis, renal colic, spastic colitis, bronchospasm, endarteritis, migraines and many other diseases. When administered rectally, the drug is quickly absorbed and its active components enter the bloodstream. The therapeutic effect occurs quite quickly.

Compound

Papaverine is available in several dosage forms. These are tablets, injection solution and rectal suppositories. Many experts claim that Papaverine suppositories are the safest form of release. One suppository contains 20 mg of the active ingredient – ​​papaverine hydrochloride.

Properties of the drug

Papaverine hydrochloride suppositories, after administration into the rectum, affect the smooth muscles of the bronchi, lungs, large and small intestines, stomach, and uterus. However, the effect of the drug does not apply to the muscles of the skeleton and heart. After the product enters the body, these muscles work as usual.

Properties of the drug:

• elimination of smooth muscle tone in various pathologies;
• lowering blood pressure, dilating blood vessels;
• increased blood flow in all internal organs;
• normalization of heart rate;
• providing a sedative effect.

During childbirth, women are prescribed Papaverine suppositories to relieve cervical hypertonicity. Many people are interested in how to administer the drug vaginally or rectally? Papaverine suppositories are inserted into the patient's anus.

Indications

What is the medicine used for? Papaverine suppositories are used for many diseases that are accompanied by pain. The drug is widely used in gynecology, urology, and surgery.

Main indications:

• all types and stages of hemorrhoids;
• headaches caused by vasospasm;
• pain syndrome in various diseases of the digestive system;
• renal colic;
• pathologies of the urinary tract – pyelonephritis, cystitis, urolithiasis, urethritis;
• bronchitis, pneumonia;
• pain in women during menstruation.

Papaverine helps relieve spasms in various diseases

Papaverine suppositories have a positive effect on the gastrointestinal tract during constipation and help normalize stool. The drug effectively fights migraines. For bronchitis, the medicine relieves spasm from the bronchi and helps prevent swelling of the mucous membrane.

Mechanism of action

The therapeutic effect of Papaverine suppositories is ensured by suppressing the phosphodiesterase enzyme. Thanks to this, it is possible to relieve muscle spasms and relax muscle fibers. The medicine has an effect on the human genitourinary, digestive, and hepatobiliary systems, and also relieves vasospasm. The active component papaverine hydrochloride increases the lumen of blood vessels, thereby normalizing systemic blood pressure. After administration of the drug, its active component quickly penetrates the bloodstream. Papaverine hydrochloride is evenly distributed throughout the body, affecting the central nervous system.

Important! During use during pregnancy, the drug can penetrate the placenta to the fetus and enter milk during breastfeeding.

Contraindications

The instructions for use include a number of contraindications that must be taken into account when using the medicine. These include:

• the presence of an allergy to the components of the drug;
• increased intraocular pressure in glaucoma and other diseases;
• liver failure, accompanied by severe course;
• blockade of the heart muscle;
• old age of the patient;
• children's age up to 12 years.

Papaverine is prescribed by a doctor who must study the patient’s medical history and exclude all possible contraindications.

How to light candles

Where to insert Papaverine and how often can it be done? Suppositories should be used only as prescribed by a doctor. Typically, adults are administered 20 - 40 mg of the drug 2-3 times throughout the day. Sometimes a specialist may adjust the dosage depending on the diagnosis. Considering the question of how long the drug takes to act, it should be noted that on average the effect occurs after 30 – 40 minutes. Sometimes you have to wait longer for results. This depends on the characteristics of the disease and the individual qualities of the body.

The suppository should be administered according to the instructions.

With uterine hypertonicity

Increased uterine tone threatens premature birth. Papaverine suppositories help relieve spasms and relax smooth muscles. According to the doctor’s recommendation, a woman is given 2–3 suppositories throughout the day to tone the uterus. It is advisable for every pregnant woman to have this medicine in her home medicine cabinet, since when a spasm occurs, this drug will become an ambulance. The drug should be used carefully during treatment with other vaginal and rectal suppositories.

Sometimes the medicine is used among women in labor during false labor. During this period, the woman experiences pain in the uterus and lower back, but this condition is only a harbinger of an imminent birth. To make a woman feel better, suppositories can be prescribed.

Treatment of prostatitis

For prostatitis, Papaverine helps eliminate pain and unpleasant pulling sensations. During the period of exacerbation, 1-2 suppositories are inserted into the anus. three times a day. Before starting treatment, it is important to make sure that you are not allergic to any of the components of the product.

Papaverine for hemorrhoids

How to place Papaverine suppositories for hemorrhoids? As with other diseases, suppositories are used rectally. The dosage for a particular patient is selected by the doctor, taking into account the characteristics of the course of the disease, the type and stage of the disease. Typically, the dose of medication for varicose veins in the anal area is 1 - 2 suppositories three times a day. The duration of therapy depends on the achieved therapeutic effect.

Use of Papaverine among children

Papaverine for children is used under the strict supervision of the attending physician. The instructions for use say that the medicine is prescribed to children over the age of 12, but in some cases a specialist may prescribe the medicine to a child under this age.

The drug should be used with caution among children

Possible side effects

Negative phenomena associated with the use of suppositories are extremely rare. This is evidenced by numerous positive reviews from patients and doctors who have tested the drug in practice. Sometimes during treatment with the product, minor itching and irritation occurs in the anal area. If the dose is greatly exceeded, the patient may experience the following complications:

• violation of the heart rhythm;
• dizziness;
• apathy and drowsiness;
• difficulty urinating and defecating;
• nausea, less often vomiting.

Treatment of the complications described above consists of blood purification and symptomatic treatment of the patient.

Important! If alarming signs develop during therapy with Papaverine, you should stop taking the drug and immediately visit a doctor.

Combination with other medications

With the simultaneous use of Papaverine with antihypertensive drugs, the effect of the latter is enhanced. The antispasmodic effect of papaverine hydrochloride increases when taking barbiturates. The hypotensive effect of the drug increases when administered simultaneously with drugs such as tricyclic antidepressants, Quinidine, Procainamide, Reserpine.

special instructions

When starting treatment with the drug, you should carefully study the instructions for use. It includes several special instructions that must be followed. These include:

• the medicine should be used with extreme caution in cases of severe renal failure;
• During treatment with suppositories, it is important to stop drinking alcohol;
• During pregnancy and lactation, suppositories are used under the strict supervision of a doctor. To date, there is not enough information about the safety of using the drug during this period;
• the active component of the drug can have a relaxing effect on the central nervous system, therefore, among people whose work activity requires increased concentration, the drug is used carefully.

In addition, if the patient is taking any other medications, be sure to inform the doctor.

Before starting treatment, it is important to read the instructions for the drug

Analogues of the drug

How to replace Papaverine suppositories? Among the analogues of the drug, the following drugs can be distinguished:

• No-Shpa is a medicine that is used for diseases associated with spasm of the smooth muscles of internal organs and blood vessels, as well as for the treatment of periodic pain;
• Spazmolysin suppositories - inserted into the anus for pain syndrome arising from diseases of the gastrointestinal tract and other organs, cholecystitis, pancreatitis, cystitis and other pathologies;
• Spascuprel - used to relax the smooth muscles of internal organs in diseases of the stomach, intestines, pancreas, kidneys and other organs;
• Theophedrine ІС – used for bronchial asthma, obstructive bronchitis to eliminate bronchospasm and ease the patient’s breathing;
• GastroComfort is an antispasmodic and carminative drug that is prescribed to patients with diseases of the digestive system;
• Niaspam - used for irritable bowel syndrome, renal and hepatic colic, and other pathologies of the digestive system.

You should take any of the analogues only after examination by a doctor.

Self-medication often causes serious negative consequences.

Terms of sale and storage

Papaverine suppositories are available from pharmacies with a doctor's prescription. It is recommended to store the medicine in a place where sunlight does not penetrate. Shelf life is 3 years, provided that the recommendations for storing the drug are followed. After this period, the product cannot be used.

Papaverine is a drug that is widely used in modern medicine. Due to the fact that there are several forms of release, it can be prescribed by a specialist to people with varying degrees of susceptibility. Indications for the use of Papaverine are different, so in hospitals, for example, injections are used, while at home you can use tablets or suppositories.

Release form and composition

Papaverine belongs to the group of opioid alkaloids produced by synthesizing various components. Its main active ingredient is papaverine hydrochloride. The medication is available in three dosage forms:

• Pills. Available in blisters of 10 pieces. Each tablet contains 40 mg of the active ingredient; in the preparation for children its share is less and is only 10 mg.
• Injection. Available as 2 ml ampoules, each containing the same amount of active substance as the tablets. Packed in cardboard packages of 5 and 10 pieces (together with a special ampoule knife).
• Rectal suppositories. The suppositories contain 20 mg of papaverine hydrochloride and are intended for administration into the rectum. They are packaged in special packs of 5 pieces each.

Papaverine is a drug that can be found in any pharmacy

Pharmacological action of the drug

Papaverine hydrochloride inhibits the activity of an enzyme called phosphodiesterase, which in turn provokes the accumulation of cyclic adenosine monophosphate at the cellular level. After this, the level of calcium decreases and ultimately this leads to the fact that the smooth muscles relax, and the number of their contractions returns to normal.

The medication can relieve a person from spasms of the smooth muscles of the intestines, stomach and other organs of the digestive system, bronchi, uterus, kidneys, urinary and gall bladder. When exposed to the components of the drug, there is an exceptionally relaxing effect, elasticity and natural movements of all muscle groups are preserved in full.

What does papaverine help with?

As mentioned earlier, Papaverine is an antispasmodic that also has a hypotensive and anticonvulsant effect. What is Papaverine used for:

• providing a sedative effect when prescribed by a specialist in large doses;
• vasodilation;
• decreased tone of smooth muscles of the genitourinary and respiratory systems, as well as the heart;
• improved blood flow.

After entering the body, the drug begins to be absorbed almost immediately; the maximum effect of Papaverine is achieved within half an hour. Excreted from the body through the kidneys.

Recommendation: if there is an urgent need to remove all components of the medication from the body, you can resort to dialysis. During this procedure, the blood is completely cleansed of toxins, as well as unnecessary and harmful substances.

When is Papaverine prescribed?

The main indications for the use of Papaverine are muscle spasms, which occur in the following cases:

• endarteritis is a disease in which the lumen in the arteries is completely blocked, which leads to impaired blood flow. Along with this, damage to internal organs begins and gangrene develops. For the most part, this disease affects the vessels located in the lower extremities;
• inflammation of the bronchi, in which bronchospasm is by no means a rare phenomenon;
• diseases of the abdominal organs - colitis, cholecystitis, renal colic;
• angina pectoris, in which certain areas of the heart stop receiving blood in the required amount. The disease is characterized by blockage or narrowing of blood vessels, as a result of which severe chest pain develops against this background;
• problems associated with blood vessels located in the brain;
• during exacerbation of attacks of cholelithiasis.

Papaverine can also be used during surgery. It is administered by an anesthesiologist to reduce muscle tone in the airways. Thanks to this, it will be much easier for the patient’s body to tolerate anesthesia.

Papaverine affects smooth muscles, regulating their tone

Is it possible to take Papaverine during pregnancy?

The vast majority of pregnant women are faced with the phenomenon of uterine hypertonicity. This condition is considered quite dangerous because it can cause premature birth. Even during attacks, blood flow to the fetus decreases, which entails negative consequences - the child simply does not receive all the necessary nutrients and substances. To reduce muscle tone, women are prescribed Papaverine, which can also lower blood pressure if it suddenly rises. Along with this, blood flow to the uterus improves, which has a positive effect on the development of the child.

Another positive property of Papaverine is that it has a sedative effect. It relieves nervous tension, which is typical for many pregnant women, and it is this that, as is known, can provoke the development of uterine tone.

Important: you should take the antispasmodic Papaverine carefully during pregnancy; if you have the slightest suspicion of worsening your condition, you should stop taking it and consult a doctor.

A number of side effects are possible:

• An allergic reaction is rare, but possible. Most often, women are bothered by itchy skin and hives;
• dizziness;
• drowsiness;
• constipation;
• When administered intravenously, cardiac arrhythmias may occur.

A completely logical question that arises for many women is where, in fact, to insert suppositories (if this particular dosage form was prescribed), if they are intended for rectal administration, but it is necessary to provide a therapeutic effect in the genitourinary system? The answer is simple - where indicated, since the active components are quickly absorbed into the bloodstream and are first distributed locally to nearby organs, and then further throughout the body. This ensures that the smooth muscles of the uterus are saturated with the substances of the drug in full and in a short time.

Papaverine is often prescribed during pregnancy because it can alleviate a woman’s condition.

Contraindications - to whom and when Papaverine is prohibited

In order to avoid the appearance and development of allergic reactions, you should not take Papaverine if you have an individual intolerance to the active substance or other components of the drug. Medication treatment should be interrupted immediately if signs of allergy are detected. The instructions for the medicine state that the contraindications for Papaverine are as follows, and it is prohibited to take it:

• small children (up to 6 months);
• To old people;
• those who have arterial hypotension (low blood pressure);
• patients with glaucoma;
• people with renal failure (the kidneys simply will not be able to fully remove the components of the drug from the body);
• hospital patients in a coma.

Papaverine should be taken with extreme caution by those diagnosed with:

• traumatic brain injury;
• hypothyroidism;
• prostatic hyperplasia;
• state of shock;
• supraventricular tachycardia;
• adrenal dysfunction.

Side effects

The cardiovascular system

It is possible to develop atrioventricular block, a condition in which the electrical impulse between the ventricles and atria slows down or stops altogether. This leads to heart rhythm disturbances. Along with this, a decrease in blood pressure and ventricular tachycardia is possible.

Gastrointestinal tract

Here are the possible:

• bloating;
• nausea and vomiting;
• dysfunction of food passage through the intestines.

All other side effects of Papaverine include allergic reactions, excessive drowsiness and eosinophilia - an increase in the blood level of special cells responsible for fighting toxins and various microorganisms.

It should be remembered that side effects themselves develop extremely rarely. They can appear only in cases where a person began taking Papaverine independently and without consulting a specialist, or when he significantly exceeded the dosage recommended by the doctor.

The information in the article is for informational purposes only; self-medication is not recommended. Only a doctor should prescribe Papaverine and select the dosage.