Medicinal reference book geotar. Oseltamivir - antiviral medicine, instructions for use

Oseltamivir is an antiviral medicinal product, effective against influenza viruses of types A and B.

Pharmacodynamics

The antiviral result is demonstrated by the active biotransformation product of Oseltamivir - oseltamivir carboxylate, which is considered selective inhibitor influenza virus neuraminidase.

Neuraminidase is a glycoprotein, under the influence of which the process of spread of the virus in the respiratory system occurs due to the obstruction of activity protective function epithelial mucus from tissue damage by the influenza virus. Neuraminidase promotes the release of virions from the virus cell and their damage to respiratory tissues.

Oseltamivir carboxylate blocks the activity of neuraminidase, thereby inhibiting the growth of the influenza virus outside a living organism, and also significantly reducing its replication activity and pathogenic properties after entering the human body.

The use of Oseltamivir helps reduce the release of influenza A and B viruses from the body.

Pharmacokinetics

The absorption properties of oseltamivir phosphate have a high degree of activity in the gastrointestinal tract after oral administration. Oseltamivir carboxylate is formed from oseltamivir phosphate that enters the body with the help of hepatic and intestinal esterases. Sufficient for offensive therapeutic effect the amount of the active metabolic product is observed in the plasma 30 minutes after administration, and its maximum values ​​are determined after 2–3 hours. In this case, there is a significant predominance of the active metabolite (20 times) compared to the level of the original substance. About 3/4 of the drug taken orally enters the general bloodstream in the form of an active biotransformation product.

The level of the prodrug and its active product in plasma does not change when used together with food.

The volume of distribution of oseltamivir carboxylate is approximately 23 liters. Specified substance mainly distributed in tissues affected by the virus (lungs, bronchopulmonary secretions, mucous endothelium of the nasal passages, hearing organs, trachea), in quantities sufficient to effective therapy. The ability of the active metabolite to bind to plasma proteins has low level(about 3%), while the level of prodrug binding is average level– about 40% (the degree of binding of the active metabolite to plasma proteins, and even more so the parent substance, is too low to form clinically significant types of interaction with other drugs).

Excretion of the drug occurs through the excretory function of the kidneys (with urine) mainly in the form of oseltamivir carboxylate - more than 90% (which does not undergo further transformation).

T1/2 of oseltamivir phosphate is 1–3 hours, its pharmacologically active product is 6–10 hours. Renal clearance is 18.8 l/h. Less than 20% of the drug is excreted through the intestines.

Pharmacokinetic characteristics of the drug in special cases

1. Patients with nephropathologies

The excretion potential of the active metabolite is inversely proportional to QC.

When CC is less than 30 ml/min, dosage adjustment is necessary;

with CC less than 10 ml/min) - drug elimination has not been studied.

2. Patients with hepatopathologies

Significant changes no elimination of the prodrug and its active metabolite was observed in this group.

3. Patients of the gerontological group

In patients of this group, there is an intensification of the excretion capacity of the drug by 25–35%, in comparison with young patients (at an equivalent dose).

No changes in T1/2 were noticed. No adjustment of the dosage regimen is required in this group of patients.

4. Pediatric group

The elimination of the drug in children over 13 years of age corresponds to those of adult patients.

Indications for use

Oseltamivir is prescribed by a doctor to patients over 13 years of age for the prevention and treatment of influenza virus types A and B.

Mode of application

Oseltamivir is prescribed as an antiviral agent to patients aged 13 years and older. It is advisable to take the drug with food - this significantly reduces its adverse effects on the patient’s body and improves tolerability.

Flu therapy

The medication should be started no later than 2 days after the onset of the first symptoms of the disease in order to increase therapeutic effectiveness this tool.

In the role prophylactic

To prevent influenza infection during an epidemic or after contact with an infected patient (you should start taking the drug urgently), it is recommended to take the drug 75 mg once a day for 10 days. At the discretion of the doctor, the duration of taking Oseltamivir as a means of preventing influenza can be extended to 6 weeks.

VSD medications for adults is 150 mg/day. Further excess of the dosage does not have a positive effect on the therapeutic result of the drug, but can only lead to an overdose.

Patients with nephron disorders

If the patient's CC varies between 10–30 ml/min, then the therapeutic dose recommended above should be reduced (to 75 mg once a day for 5 days). In patients with CC values ​​below 10 ml/min, the specifics of use have not been studied.

The prophylactic dosage of the drug for patients with CC 10–30 ml/min should be reduced to 75 mg once every two days (that is, the medication should be taken every other day). In patients with creatinine clearance levels below 10 ml/min, features prophylactic use have not been studied.

Side effects

Contraindications

It is strictly not recommended to prescribe the medicine to patients under 13 years of age, as well as in the presence of individual intolerance to the active substance or other components of the composition.

Pregnancy

To date, the teratogenicity and phototoxicity of the drug when used to prevent and treat influenza in pregnant women has not been studied in detail. Research in this area continues. Therefore, taking into account the unfavorable outcome of the initial disease on the development of the fetus, the drug is allowed to be used in the treatment of pregnant women only with the permission of the attending physician and taking into account the degree of risk adverse effects for the fetus and benefits for the mother.

Lactation and taking this drug are mutually exclusive.

Drug interactions

As already stated above, clinically unlikely significant species interactions of Oseltamivir with other drugs - this is due to the low degree of binding of the substance to plasma proteins, and, accordingly, the low ability to displace other drugs from binding with proteins.

An intensification of the excretion properties of the active biotransformation product of oseltamivir was noted (by 50%) against the background simultaneous use probenecid due to inhibition of tubular secretion in the kidneys. The condition does not require a change in dosage regimen.

Overdose

To date, there have been no reports of excessive dosing of the drug. It has been established that in case of acute overdose, nausea and vomiting can be observed, and if they occur, it is recommended to symptomatic treatment.

Release form

The drug is available in the form of hard gelatin capsules (No. 2), the capsule body is brown, the cap is cream-colored. There is an inscription in black “OR” on the cap of the capsule shell, and “75” on the body. The encapsulation mixture is a white (or almost white) powder.

Capsules are packaged in 10 pcs. in a blister pack (blister), - 1 blister in a cardboard box with an annotation.

Storage conditions

The drug should be stored for no more than 2 years from the date of manufacture in a dry, dark, cool (at a temperature not exceeding 25°C) place.

Additionally

On prescription.

The drug is approved for use in patients over 13 years of age.

The effectiveness of the drug against infection with other viral agents (except influenza viruses types A and B) has not been established experimentally.

There was also no evidence of therapeutic efficacy when starting the medication 40 hours or more after infection.

There is no information on the effectiveness of the drug in patients with chronic cardiopathologies and lesions respiratory system, as well as in patients with other severe diseases and patient conditions requiring inpatient treatment.

When conducting reuse Oseltamivir as a therapeutic and prophylactic agent has not been established for its effectiveness and safety.

Before taking the medicine, you should exclude bacterial etiology disease (given the similarity of symptoms at the onset of the disease) and confirm infection with the influenza virus specified types, since the drug is ineffective against bacterial pathologies.

The inhibition of central nervous system functions (which may affect psychomotor speed and alertness) under the influence of the drug has not been experimentally established. But before driving or engaging in other types of potentially hazardous activities during the treatment period, you should take into account possible dizziness from taking the medication, as well as the danger of life activity, which is caused by the symptoms of the original disease (in particular, severe hyperthermia).

Latin name: Tamiflu
ATX code: J05AH02
Active substance: Oseltamivir
Manufacturer: Hoffmann-La Roche, Switzerland
Conditions for dispensing from a pharmacy: On prescription

Indications for use

Tamiflu can be used for the following purposes:

• Treatment light form influenza in children and adults
• Prevention of influenza in people who are at risk (work in large teams, have weakened immune systems)
• Treatment of severe influenza groups A and B
• Treatment of fever caused by viruses or bacteria.

A sore throat does not always indicate the flu, it is better to know possible reasons such deviations in order to eliminate them in time. Read about this in the article:

Medicinal properties

Tamiflu is antiviral medicine, which effectively suppresses the replication and pathogenicity of influenza viruses of groups B and A.

After taking Tamiflu, it makes the flu easier. Already on the fifth day of therapy, the patient’s manifestations of the disease decrease (decreases heat, cough and fever go away). The general condition of the patient also improves.
Oseltamivir is rapidly absorbed into the blood. It reaches its maximum concentration within half an hour after administration.

The drug is excreted by the kidneys and urine.

Tamiflu capsules

Price: from 956 rub.

1 capsule contains:

• Oseltamivir.

Additional components:

• Furamat
• Gelatin
• Starch
• Artificial colors
• Talc.

This drug is available in the following dosage forms:

• Hard gelatin capsules gray with the distinctive inscription "ROCHE 75 mg". Without taste and smell.

The capsules contain white granular powder. Without smell. 1 blister pack of 10 pcs.

Directions for use and doses

The tablets can be taken regardless of meals.
The permissible dose for adults and children weighing more than forty kg is 1 tablet. twice a day.
The duration of treatment is five days.
For patients with severe kidney disease, reduce the dose to 1 tablet every two days. The duration of therapy in this case is determined by the observing doctor.

Tamiflu powder

Cost: 1302 rub.

1 mg ready suspension contains:

• Oseltamivir (active ingredient).

Additional substances:

• Saccharin
• Benzonate
• Permasil.

Available as a white granular powder for the preparation of a suspension in dark sunscreen bottles. Has a sweetish taste fruity taste and smell. After mixing with water, the powder forms a white, opaque liquid.

Dosage: 30 g in 1 bottle.

Directions for use and doses

To prepare the suspension, you can use the following procedure:

• Take the bottle and shake it several times
• Open and add 50 ml of clean water to it
• Close the bottle and shake it for half a minute until the dry granules are completely dissolved
• Carefully remove the protective cap of the bottle
• Using the measuring syringe included in the kit, dial required amount suspensions.

The prepared solution can be taken both before and after meals. It is not at all necessary to use any special devices, since you can take the solution directly from a dosing syringe.

The duration of treatment is determined by the attending physician for each patient individually.

Acceptable daily dose for adults is 150 mg.

For children weighing more than forty kg and adults (for the prevention of influenza), 70 mg of the drug is usually prescribed for ten days.

• A child older than one year and weighing less than 15 kg drinks 30 mg of the drug
• A child from two to five years old and weighing from 15 to 25 kg drinks 40 mg of the drug
• A child over 6 years old and weighing from 25 to 40 kg drinks 60 mg of the drug.

During pregnancy and breastfeeding

Tamiflu should be prescribed with extreme caution during pregnancy. It can only be taken in the third trimester of pregnancy when the viral strain of influenza is rapidly progressing and can cause serious harm to the health of the mother and fetus. In this case, the attending physician must understand possible risks from taking medication.

Why it should not be taken during lactation: due to the fact that the active substance of the drug can be excreted along with breast milk, it is contraindicated to drink during lactation so as not to endanger the baby’s health.

Contraindications

Tamiflu is not prescribed for the following indications:

• Individual intolerance to the substance oseltamivir
• Pregnancy (especially the first and second trimester)
• Lactation period
• Patient age up to one year
• The patient's weight is up to fifteen kg.

Precautionary measures

Should be taken with caution this drug with such health problems:

• Chronic heart disease
• Severe vascular diseases.

Due to the fact that oseltamivir can affect the nervous system, it is better for patients to refrain from driving or driving during treatment. complex mechanisms that require increased concentration attention.

For the purpose of prevention (during therapy), the behavior of children and adolescents should be carefully monitored for the presence of abnormalities. nervous system. This is explained by the fact that some adolescents experienced seizures and neuropsychiatric pathologies after taking these capsules.

Interaction with other drugs

Concomitant use of oseltamivir with amoxicillin and paracetamol does not have any effect negative influence on the concentration of the latter in the blood.

Laboratory tests did not reveal any negative reactions substances oseltamivir with the following medications:

• Azithromycin
• Beta blockers
• Xanthine
• Penicillin
• Captopril
• Cephalosporin
• Ranitidine
• Cemetidine
• Thiazide diuretics
• Ibuprofen, Nurofen and other non-narcotic analgesics
• Bronchodilators.

Side effects

This medicine may cause the patient to experience such side effects:

• Nausea
• Diarrhea
• Vomit
• Stomach ulcer
• Colitis
• Abdominal pain
• Bleeding in the gastrointestinal tract
• Dysbacteriosis
• Deterioration of liver function
• Hepatitis
• Jaundice
• Pancreatitis

Nervous system

• Sleep disturbance
• Neurosis
• Headache
• Agitation
• Convulsions
• Nervous excitement
• Depression
• Hallucinations

Additional effects

• Tracheitis
• Dermatitis
• Internal or nose bleed
• Arrhythmia
• Eczema
• Cough
• Rhinorrhea
• Conjunctivitis
• Asthma
• Excessive sweating
• Pneumonia
• Hypersensitivity
• Erytherma
• Anaphylactic shock

Overdose

There were no recorded cases of overdose with Tamiflu. Since the substance oseltavimir does not have any special antidote, in case of an overdose the patient (for the purpose of prevention) can rinse the stomach so as not to endanger his health. Further treatment carried out based on the observed symptoms.

Conditions and shelf life

The medicine in both forms of release should be stored in a dry place at a temperature of up to 20 degrees Celsius.

Keep out of the reach of children.

Shelf life of capsules: 4 years from the date of manufacture indicated on the package.

Shelf life of undissolved powder: 2 years from the date of manufacture.

The finished suspension (shelf life) is stored for up to ten days. It is better to store it at temperatures up to twenty degrees Celsius.

Analogues

Zanamivir

Glaxo Wellcome Production, France.
Price: from 2410 rub.

Main action: antiviral, antimicrobial. Ingredients: zanamivir (active substance). Release form: powder for inhalation.

Pros:

• Can be used for both treatment and prevention of viruses
• It has a powerful inhibitory effect, due to which it quickly frees infected cells from the virus.

Minuses:

• Contraindicated in children under five years of age
• May cause facial swelling
• Not compatible with inhaled drugs.

Medica Holding, Russia.
Price: from 148 rub.

Main action: antipyretic, antiviral, immunomodulatory. Composition: antibodies to human interferon gamma (active substance). Release form: capsules in blisters, tablets of 10 pcs. in 1 blister.

Pros:

• Facilitates the overall course of the disease
• Reduces the risk of contracting the flu by 96%
• Promotes the production of antibodies to the virus.

Minuses:

• May impair kidney function, therefore contraindicated in acute or chronic renal failure in the patient
• Prohibited for use by children under one year of age
• May cause nosebleeds, hallucinations and headaches.

Valenta Pharmaceuticals, Russia.
Price: Ingavirin costs 456 rubles.

Main action: anti-inflammatory, immunomodulatory, antiviral. Ingredients: imidazolylethanamide. Release form: Ingavirin is available in the form of blue and red tablets, 7 pcs. in 1 blister.

Pros:

• Ingavirin can cure severe ARVI in just a week
• Effectively helps relieve symptoms of the disease (weakness, fever)
• Can be purchased without a prescription.

Minuses:

• Ingavirin is contraindicated in children and adolescents under eighteen years of age (prohibited for use in pediatrics)
• Do not use together with antibiotics, as this may cause unwanted reactions.

Dalkhimfarm, Pharmstandard-Tomskkhimpharm, Russia.
Price: Amiksin costs from 740 rubles.

Main action: Amiksin has a strong immunomodulatory and antiviral effect.

Composition: tilorone (active substance).

Release form: Amiksin is available in the form of convex tablets of pink or orange color(depending on dosage) 5 or 10 pcs. packaging.

Pros:

• Amiksin stimulates the production of interferons in the body, due to which a person’s resistance to certain strains of viruses increases
• Reduces immunosuppression (when the immune system is weakened all the time)
• Has high bioavailability (almost 85%).

Minuses:

• May cause dyspepsia
• May cause chills.

Pharmstandard-Tomskkhimpharm, Russia.
Price: 378 rub.

Main action: Arbidol has a strong antiviral effect Composition: umifenovir (active substance). Release form: yellow capsules with white powder, 10 pcs. packaged.

Pros:

• Arbidol helps to quickly suppress the activity of viruses
• Arbidol increases the body's overall resistance to viral infections (increases immunity)
• Can be purchased without a prescription.

Minuses:

• Cannot be used on infants
• Strictly contraindicated during pregnancy.

A drug Oseltamivir- direct acting antiviral agent.
It is a prodrug whose active metabolite (oseltamivir carboxylate) selectively inhibits neuraminidase of influenza virus types A and B. Neuraminidase is a glycoprotein that catalyzes the cleavage of the bond between terminal sialic acid and sugar, thereby facilitating the spread of the virus in the respiratory tract (the release of virions from the infected cell and penetration into epithelial cells respiratory tract, preventing inactivation of the virus by epithelial mucus). Oseltamivir carboxylate acts outside cells and competitively inhibits viral neuraminidase. Inhibits the growth of the influenza virus in vitro and suppresses the replication of the virus and its pathogenicity in vivo. Reduces the release of influenza A and B viruses from the body.
Does not affect the production of antibodies in response to administration inactivated vaccine against the flu.
The resistance rate of clinical isolates of the virus is 2%.

Indications for use

Mode of application

Side effects

Contraindications

Pregnancy

Interaction with other drugs

Overdose

Storage conditions

Release form

Compound

Additionally

Main settings

The onset of the first cold weather always alarms us with the appearance of respiratory viral infections. Panic on the radio, television, among friends is instantly stored in the mind, and a person begins to listen to his body in anticipation of a “terrible” virus.

In this article, we will look at cheap analogues of the drug Tamiflu and compare their effectiveness.

Are they really that dangerous? viral infections? Among doctors working in infectious diseases departments, there is an opinion that what more fear before the disease, the sooner you will receive it. Doctors and nurses have been working for years in dangerous hospitals (for example, tuberculosis hospitals, without wearing a protective mask), and do not suffer from these infections. The percentage of infected personnel in infectious diseases departments is very low.

If you remember Soviet times, then there was no loud trumpet about viruses, and there was no such panic among the population. People went to the skating rinks, rolled around in the snow, and actively visited New Year's performances and they weren’t so afraid of ARVI. Fear is the main culprit of many diseases, even common ARVI. Besides low immunity our citizens want to be the best.

Of course, one cannot completely dismiss “trifling” viruses, because... However, there is still a large group of people with immunodeficiencies who require auxiliary antiviral therapy with the flu, and sometimes with serious medications, such as the drug Tamiflu.

It is also necessary to note the inappropriateness of prescribing antiviral drugs in cases where the body copes completely independently with the help of only traditional methods, producing protective persistent antibodies.

In our article we’ll talk about the sensational, expensive antiviral drug Tamiflu, which was used during the epidemic swine flu they spoke as if it were almost a panacea. Let's get acquainted with analogues of Tamiflu, which are much cheaper and more accessible to the general public.

Tamiflu - instructions

To compile a list of Tamiflu analogues and select worthy products that will not only therapeutically satisfy the patient, but also cost less, let’s consider its main parameters.

Release form, price, composition, storage

The drug is available in the form of capsules (75 mg No. 10) and powder for suspension (12 mg/1 ml) - 30 grams active substance in a bottle. Today, the average price for capsules is 1,200 rubles.

The availability of the powder and its price should be checked at a specific pharmacy, because Lately Internet search engines do not provide information about this form of the drug. Usually the powder costs 150 rubles more.

The active ingredient in Tamiflu is oseltamivir.. The shelf life of the drug is 5 years.

Indications

The drug is used for the prevention and therapeutic therapy influenza (type A and B), as well as parainfluenza. Tamiflu is prescribed to children as early as 12 months. In practice, the remedy is used earlier, starting from six months.

Contraindications

It is not recommended to use Tamiflu for severe renal pathologies and insensitivity to the main one, as well as auxiliary staff. Relative contraindication is pregnancy and lactation, but at the discretion of the doctor, Tamiflu can be used during this period.

Adverse reactions

Sometimes the following side effects may occur:

• dizziness;
• nausea (sometimes vomiting);
• epigastric pain;
• upset stomach (diarrhea, or feeling the urge to stool);
• weakness;
• hallucinatory manifestations;
• sleep disturbance;
• allergic reactions;
• cough;
• laryngitis;
• conjunctivitis;
• other.

Dosage

When the first symptoms of influenza appear, the drug should be used no later than 48 hours.

For babies, a suspension is used, because the child cannot swallow capsules. If the powder is not available for sale, you can use the contents of the capsules to prepare the suspension. The calculation of the required dose is carried out by the pediatrician, taking into account the age and weight of the child.

Patients weighing at least 40 kg take capsules twice a day (morning and evening). After 12 years, it is also recommended to take Tamiflu twice for 5 days, i.e. A blister of 10 tablets is used.

For the purpose of prevention, dosages should be as follows:

• For patients weighing more than 40 kg, as well as for children over 12 years of age, Tamiflu is prescribed for 10 days, 1 capsule per day;
• For children, preventive doses are determined only by a pediatrician.

After reading the instructions, it is easy to notice that Tamiflu is used only for the flu, has a high price and big list potential adverse reactions. On a positive note is the possibility of treating influenza in young children.

Of course, not all patients are ready to pay 1200 rubles for 10 tablets of Tamiflu, yet “our patient” is always looking for a cheaper alternative so that the price does not hit his pocket. Do such analogues exist? Let's try to figure it out.

Doctor Komarovsky about the drug Tamiflu

List of cheap analogues

Almost everything antivirals Tamiflu is cheaper, so the list of analogues will be long. But we will not list information from pharmacological reference books, but let’s present a list of drugs that, according to statistics, are most often used for the flu, as an alternative to Tamiflu:

• ingavirin 60 mg (7 capsules) – 370 rubles;
• arbidol 100 mg (10 caps.) – 230 rubles;
• Relenza 20 mg (5 rotadiscs) – 1100 rubles;
• kagocel 12 mg (12 tablets) – 270 rubles;
• amiksin 60 mg (10 tablets) – 600 rubles;
• cycloferon 150 mg (10 tablets) – 190 rubles;
• Anaferon (20 tablets) – 230 rubles.

Tamiflu or Ingavirin – which is better?

Cheap Russian analogue Ingavirin is considered an excellent replacement Tamiflu, and not only in price, but also therapeutic effect. Therefore, high sales of this drug have been noticed recently.

Ingavirin has more wide indications than Tamiflu. It is prescribed for ARVI, adenoviruses and other respiratory infections. Tamiflu is used only for the flu.

Unlike Tamiflu, ingavirin suppresses not only viruses, but also relieves inflammation, eliminates toxins, activates the production of its own interferon, and eliminates catarrhal phenomena. The drugs in question have absolutely different composition, That's why structural analogues are not.

Lack of ingavirin - the drug is used only from 18 years of age(dosage 90 mg) and from 7 years (60 mg). Tamiflu is recommended for use starting from 12 months of a child’s life. The advantage of Ingavirin is that it does not have a toxic effect, like Tamiflu.

According to clinical trials There is evidence of a more pronounced antiviral effect of ingavirin compared to Tamiflu.

The price of ingavirin is 3.5 times cheaper.

Relenza or Tamiflu – what to choose

Unlike Tamiflu, amixin is used only from the age of seven, and its price is half the price. The area of ​​use is not limited to influenza. Amiksin is a frequently prescribed drug for respiratory infections, which has not only antiviral activity, but also a pronounced immunomodulating property.

Amiksin shows effectiveness against herpes, cytomegalovirus, viral hepatitis, and other pathologies viral origin. Amiksin is non-toxic compared to Tamiflu, and side effects are so rare that they are practically reduced to zero. Most often this is an individual intolerance to the composition of the drug.

Amiksin or Tamiflu - which is better? It is impossible to answer unequivocally. It is necessary to consider specific clinical case, taking into account symptoms, age, allergy history and immune status patient. Only a set of this information about the patient will help you choose one of these remedies.

Cycloferon or Tamiflu - which is better?

Despite its inexpensive cost, the drug shows high efficiency for many diseases: influenza, ARVI, viral hepatitis, HIV, neuroinfections, others. This effect is achieved through a combination of three properties of the drug: antiviral, anti-inflammatory and immunomodulating. Lucky combination active ingredients allows in fast deadlines eliminate symptoms of influenza and ARVI.

Unlike Tamiflu, the drug is only in tablet form and is used in children only from 4 years of age. Cycloferon has no side effects, except for possible allergic reactions. Therefore, long-term courses of taking this drug are safe, which allows treatment in patients with immunodeficiencies, such as HIV infection.

The price of Cycloferon is 5 times less, it is not surprising that patients quite often prefer it to Tamiflu.

Anaferon or Tamiflu – what to choose

This drug is classified as homeopathy, the composition of which includes affinity-purified antibodies to human interferon gamma. Anaferon has two tablet forms: adult and children's. The second form allows you to use the product with one month old child. For the youngest patients, the tablets are turned into powder and dissolved in water according to the prescribed dose.

There are more indications for the use of Anaferon than Tamiflu. These include: herpes virus, Infectious mononucleosis, acute respiratory viral infections, immunodeficiencies, bacterial lesions, other pathologies. Homeopathy acts gradually, forcing the body to “get out” on its own using its own reserves and self-healing. In the future, this helps reduce the number of relapses of respiratory infections.

Anaferon activates antiviral immunity, and works slower than Tamiflu for the flu. For aggressive acute respiratory viral infections and influenza, anaferon is more suitable as complex therapy of these diseases than individually, but with good immunity in a patient, even with influenza infection, it can also be used as monotherapy.

We can conclude that Tamiflu is an antiviral agent, and Anaferon is an activator of antiviral immunity.

The price of Anaferon is significantly lower than that of Tamiflu, approximately 5 times.

Issue on the effectiveness of Tamiflu

Conclusion

Selecting analogues is not always easy. Of course, if the replacement is made only taking into account the price, then there is no problem, we compared the cost and took the drug cheaper. But this approach, to put it mildly, is philistine, and has nothing in common with professionalism. It’s good if the drug is suitable and has the expected effect of treatment.

Unfortunately, often pharmacies, seeing the buyer’s desire to buy a cheap antiviral drug, offer remedies, taking into account only the price, but not the patient’s complaints. Although in principle they are not obliged to advise patients at all.

It’s a pity when patients in the first days of influenza and ARVI do not receive professional help, and then Tamiflu or its analogs purchased at a high price will no longer bring the expected result by at least 50%. The money is wasted, and there remains disappointment about the drug and the entire course of treatment.

Remember, antiviral drugs are selected exclusively by the doctor, because The doctor always adjusts the dosage according to the instructions, according to the ongoing flu or acute respiratory viral infection. Sometimes the course of treatment lasts only three days, and in some cases it is recommended to extend anti-influenza therapy longer than even indicated in the instructions. Be healthy!

Attention, TODAY only!

Efficacy of the drug

The most effective antiviral drug The one currently used is oseltamivir.

Being an inhibitor of the neuraminidase enzyme, it affects one of the links in the reproduction of the virus, which leads to its death. The drug is a representative of the third generation of this group. The previous drug, zanamivir, can only be used as a nasal spray and then with major side effects that limit its use. The developers tried to avoid these shortcomings with oseltamivir.

The drug oseltamivir ( tradename Tamiflu) is produced by a Swiss pharmaceutical company. It has undergone serious repeated tests in the USA, Holland, Great Britain, and Asian countries, conducted on both animals and humans. Sufficient part scientific works is devoted to studying the effect of the drug on birds infected with the H1N1 virus. The results of these experiments are very encouraging, which made it possible to classify Tamiflu as a drug with proven effectiveness against the influenza virus.

Studies show that the use of the drug reduces the average duration of the disease by 30-40%, and the severity by the same amount clinical manifestations his. The risk of developing influenza complications is reduced by 1.5 times, and the number of deaths among elderly patients is reduced by the same amount. All these data indicate great prospects.

The most effective is to take it in the first 48 hours from the onset of the disease.

However, there is positive evidence for its use in more late dates, and also with good effect.

Flaws

The significant disadvantages of oseltamivir as a drug for influenza include its narrow spectrum of action, which allows the drug to be used only against influenza A and B viruses, that is, only during an epidemic when the pathogen has already been laboratory confirmed. Considering its mechanism of action, the drug may be ineffective at the prevention stage, although manufacturers are very optimistic here too and offer the necessary treatment regimens for this.

A significant disadvantage of oseltamivir for influenza is its price. Despite the fact that since 2009, when it began to be actively used during the epidemic, the price of the drug has decreased by 3 times, it is still high and amounts to about 1000 rubles for 10 capsules.

Side effects

The drug is available in the form of capsules and powder for the preparation of a suspension, which allows its use in children after one year, thereby expanding the scope of application. Compared to its predecessor, zanamivir, side effects are less pronounced. However, it is possible

• development of allergic reactions;
• dyspeptic disorders (nausea, vomiting, diarrhea);
• nervous disorders (dizziness, headache, sleep disturbance, convulsions);
• cough, sore throat, difficulty breathing, even bronchospasm.

The instructions for oseltamivir for influenza indicate that the drug is contraindicated in patients with severe violations kidney function, in the presence of allergic reactions to the components of the drug.

During pregnancy and lactation it can be used with great caution.

The drug belongs to the same group of drugs Russian production arbidol, very actively advertised by the media and official sources. Constant availability of arbidol in the pharmacy network and affordable price make it competitive with Tamiflu.

However, the main criterion, the effectiveness of the drug, is an unproven fact, since there is no reliable information about the tests being carried out.

However, there are and are not uncommon positive reviews about the use of arbidol as medicine with the flu.

Choice medication for influenza should be carried out quickly and directly by the attending physician, who will prescribe the drug based on general condition the patient, as well as data on the epidemiological situation and the suspected pathogen.