Panangin concentrate for preparing a solution. Instructions for intravenous use. Possible negative reactions

The drug panangin is an important source of electrolytes (magnesium, potassium ions) for the activity of the main organ. In addition, it expresses effects on metabolic processes. The product is produced both in tablets, and you can find panangin in ampoules, the instructions for use of which prescribe what diseases the medication is indicated for and how it is used.

One of the forms of release is a solution for internal use, also these are ampoules for injection.

The medicine contains components that are important for the body. These are substances such as potassium and magnesium. With a lack of these substances in the body, a large number of problems arise in the activity of the heart.

The main purpose of the substance potassium is to maintain the membrane capacity of myocytes, neurons, and tissue structures of the myocardium. When the balance between the extracellular and intracellular presence of potassium is disturbed, a decrease in contractions of the heart muscle occurs, and then the manifestation of arrhythmia and tachycardia occurs.

The substance magnesium is one of the main substances in most of the effects of fermentation, active metabolism, and the integrity of nucleic acids. It affects the activity of the main organ, favoring a decrease in the tension of contractions, reduces the frequency of contractions of the function of the main organ and the need for myocardial oxygen. Thanks to the substance magnesium, a pronounced anti-ischemic effect on the myocardium occurs.

Together, these 2 components present in the solution reduce the toxicity of cardiac glycosides without affecting their inotropic activity.

In addition, the combination of components indicates that a lack of one of them leads to a deficiency of the other and leads to the manifestation of the following diseases.

Hypertension.
Atherosclerosis.
Arrhythmia.

The solution for intravenous administration has a colorless tint or a slightly greenish, transparent color.

Solution composition:

potassium asparginate - hemihydrate;
magnesium aspartate - tetrahydrate.

An additional substance is water.

Indications for use

The medicine in solution form is indicated:

as a comprehensive treatment for heart failure, acute heart attack, with changes in heart rhythm (ventricular arrhythmia, arrhythmias provoked by an overdose of glycosides) which are determined by electrolyte changes;
with hypokalemia, when the potassium level in the circulatory system is reduced;
with changes in rhythm that are associated with intoxication with digitalis drugs;
with paroxysms of atrial fibrillation;
to improve the tolerance of cardiac glycosides;
compensate for the lack of magnesium and potassium if their intake is reduced in food.

Panangin also treats coronary insufficiency, which indicates a discrepancy between cardiac oxygen demand and oxygen supply.

How to use the solution

Panangin is prescribed intravenously; a slow injection of the solution is required, 20 drops per minute. If necessary, the drug can be administered again after 6 hours.

To prepare medicine for intravenous drip, take 1 ampoule and dilute it with 5% glucose (50-100 ml).

The medicine can be used for combination treatment.

Using the solution during pregnancy and breastfeeding

There is no information about the negative effects of the drug in the form of a solution for intravenous infusion during pregnancy and breastfeeding.

Use for changes in kidney function

For acute and chronic forms of renal failure, oliguria, anuria.

Important information

It is necessary to prescribe Panangin with extreme caution to patients with an increased risk of hyperkalemia. In this case, you will need to constantly monitor the level of potassium ions in the blood.

Before using the medicine, the patient should consult a doctor.

If the drug is injected quickly into a vein, hyperemia of the skin may develop.

Panangin does not affect the ability to drive vehicles or engage in work that requires concentrated concentration and an instant psychomotor reflex.

Panangin is contraindicated

The medicine is not administered for the following diseases and conditions of the patient:

renal failure in acute and chronic form;
hyperkalemia;
hypermagnesemia;
Addison's disease;
cardiogenic shock;
dehydration;
severe myasthenia;
inferiority of the adrenal cortex;
minors;
lactation period;
during breastfeeding;
high sensitivity to the components present in the composition.

The solution is administered with extreme caution in the following cases:

with changes in liver function;
metabolic acidosis;
threat of swelling;
changes in kidney function, when it is not possible to regularly monitor the magnesium content in the blood;
hypophosphatemia;
urolithiasis, which is associated with changes in the metabolism of magnesium, calcium, ammonium phosphate.

Side effects of Panangin

When the solution is administered abruptly, signs of hyperkalemia may develop.

The patient gets tired quickly.
Myasthenia.
Paresthesia.
Confused consciousness.
The heart rhythm is disturbed (tachycardia, bradycardia).

If the patient complains of dizziness, the dose is reduced.

When signs of hypermagnesemia occur, the following may occur:

neuromuscular excitability will decrease;
reflexes to vomit will occur;
vomit;
lethargy;
blood pressure will decrease.

Phlebitis may also develop, and the amount of extrasystols will increase. With a rapid increase in the presence of magnesium ions in the circulatory system, the following occurs:

suppression of tendon reflexes;
paralysis of the respiratory system;
the person is in a coma.

For treatment, the drug is discontinued, symptomatic therapy is carried out, and calcium chloride is injected into the vein. When necessary, hemodialysis or peritoneal dialysis is performed.

Pairing Panangin with other drugs

If simultaneously used with potassium-sparing diuretics - triamterene, spironolactone, as well as beta-blockers, cyclosporine, heparin, inhibitors, ACE, NSAIDs, the threat of hyperkalemia increases, arrhythmia and asystole may appear.

When taking potassium together with GCS, hypokalemia goes away. Under the influence of potassium, you can notice a decrease in the unnecessary effects of cardiac glycosides. Panangin can also enhance the negative dromo and bathmotropic effect of antiarrhythmic medications.

Since the drug contains ions of the substance potassium, when using the product together:

with ACE inhibitors;
beta-andrenergic blockers;
cyclosporine;
heparin;
NSAIDs;
Hyperkalemia may develop, up to the occurrence of extrasystole.

Magnesium medications reduce the effects of:

neomycin;
polymyxin;
tetracycline;
streptomycin.

Calcium supplements can reduce the effects of magnesium medications. Thanks to anesthetics, the suppressive effect of magnesium on the nervous system becomes stronger.

Using Panangin with atracurium, dexamethonium, suxamethonium, an increase in the neuromuscular environment can be observed. If consumed with calcitriol, the level of magnesium in the circulatory system will increase.

Medicines that have an astringent and enveloping effect can reduce the absorption of the drug in the gastrointestinal tract. It is required to adhere to a 3-hour interval between the use of the medicine with the agents listed above.

The drug for internal use is compatible with a solution of cardiac glycosides, which improve their tolerability and reduce the unpleasant effects of cardiac glycosides.

In order to purchase panangin in the form of a solution, you will need a prescription from a doctor.

Additional substances: silicon dioxide, corn and potato starch, talc, povidone, magnesium stearate. The shell consists of talc, macrogol 6000, titanium dioxide, methacrylic acid copolymer.

Concentrate for solution (Panangin IV)

Contains magnesium aspartate (40 mg) and potassium aspartate (45.2 mg), as well as water for injection.

Release form

Available in tablet form and as a solution concentrate.

pharmachologic effect

What is the medicine for? This is a source of potassium and magnesium. The drug helps restore electrolyte balance, regulates metabolic reactions and processes, and has a pronounced antiarrhythmic effect. Potassium takes an active part in synaptic transmission, in the conduction of nerve impulses along fibers, in muscle contractions, and supports the normal functioning of the heart. When potassium metabolism is disturbed, the excitability of muscle tissue and nerves changes. Active ion transport maintains a high potassium gradient across the plasma membrane. Small dosages of potassium contribute to the expansion of the coronary arteries, and in large dosages the microelement narrows their lumen. Potassium has a moderate diuretic effect, negative bathmotropic and chronotropic effects. Magnesium is a cofactor in three hundred enzyme reactions. Magnesium is an essential element during processes and reactions that provide energy intake and expenditure. Magnesium is part of the pentose phosphate structure of DNA, takes part in the process of cell division and growth, the structure of heredity, and RNA synthesis; is a natural BMCA, prevents the release of free fatty acids and catecholamines during stress, and promotes the penetration of potassium ions into the cell. The drug has a stimulating effect on intercellular phosphate synthesis.

Mnn: potassium and magnesium aspartate.

Pharmacological group: potassium and magnesium preparation.

Pharmacodynamics and pharmacokinetics

The active substances play an important role in the formation of connections between macromolecules, as well as intracellular structures and the mechanism of muscle contraction and myocardial metabolism.

According to the annotation, the drug is well absorbed. Excreted through the kidneys.

Panangin tablets - what are they for?

Indications for use of Panangin are as follows. The drug is prescribed for hypomagnesemia, hypokalemia, when taking laxatives and diuretics, glucocorticosteroids, for diarrhea, persistent vomiting, taking saluretics, for myocardial infarction, heart failure, digitalis intoxication, ventricular extrasystole, atrial extrasystole, supraventricular tachycardia, paroxysmal tachycardia.

Example of a recipe in Latin: Rp.: Dragee “Panangin” N. 20

Contraindications for Panangin

The drug is not used for intolerance to fructose, sorbitol, impaired amino acid metabolism, chronic pathology of the renal system, hemolysis, exicosis, dehydration, arterial hypotension, myasthenia gravis, atrioventricular block, hypermagnesemia, hyperkalemia, metabolic acidosis, Addison's disease. Panangin is used with caution during pregnancy.

Side effects

Side effects are the following manifestations: ulceration of the mucous wall of the digestive tract, epigastric pain, diarrhea, bleeding from the organs of the digestive system, drop in blood pressure, bradycardia, paradoxical reaction in the form of an increase in the number of extrasystoles, dry mouth, nausea, flatulence, hyporeflexia, skin itching , dyspnea, thrombosis, phlebitis, paresthesia, dizziness, increased sweating, asthenia, myasthenia. With rapid intravenous infusion, hypermagnesemia and hyperkalemia are observed.

Instructions for use of Panangin (Method and dosage)

Panangin tablets, instructions for use

How to take the medicine? The drug is taken orally three times a day, 2 tablets. Maintenance and preventive therapy: 1 tablet three times a day, course for 3-4 weeks. In some situations, a repetition of the course of therapy is required.

Instructions for intravenous use

Panangin solution is injected intravenously, slowly. The drug is administered at a rate of drops per minute, 1-2 times a day, 300 ml. Dosing of the drug Panangin during pregnancy is carried out according to the standard regimen of medication use.

Children can take the medicine from birth.

How to take Panangin for prevention?

If you ask the question of the benefits and harms of Panangin, you should realize that this is a drug that has its own side effects, so you should not use it for prevention. Firstly, in this way you accustom the body to a high content of magnesium and potassium, and secondly, you can provoke an overabundance of these substances, which in turn can cause a lot of negative reactions.

Overdose

Manifested by muscle hypotonicity, hyperkalemia, slowing of atrioventricular conduction, cardiac arrest, arrhythmia, paresthesia of the limbs, changes in the electrocardiogram. An emergency intravenous infusion of a solution of dextrose and sodium chloride is required. If necessary, peritoneal dialysis and hemodialysis are justified.

Interaction

Panagin is able to enhance the negative bathmotropic and dromotropic effects of antiarrhythmic drugs. The medication eliminates hypokalemia, which develops against the background of long-term use of diuretics, glucocorticosteroids, and MCS. NSAIDs, ACE inhibitors, heparin, potassium-sparing diuretics, cyclosporine, beta-blockers increase the risk of hyperkalemia. When using general anesthetics, the inhibitory effect of panangin on the nervous system increases. Succinyl chloride, decamethonium, atracuronium, suxamethonium enhance neuromuscular blockade. The use of enveloping and astringent medications reduces the absorption of potassium and magnesium in the digestive tract. In combination with insulin, dextrose as part of a polarizing mixture, the heart rate is normalized in case of overdose of cardiac glycosides, ectopic arrhythmias, myocardial infarction. Panangin improves the tolerability of cardiac glycosides and is pharmaceutically compatible with their solutions.

Terms of sale

Does not require a prescription.

Storage conditions

Keep out of the reach of children at a temperature of degrees Celsius.

Panangin - instructions for use, reviews, analogs and release forms (tablets, solution in ampoules) of a drug for the treatment of potassium and magnesium deficiency, heart failure in adults, children and pregnancy

In this article you can read the instructions for use of the drug Panangin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Panangin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Panangin in the presence of existing structural analogues. Use for the treatment of potassium and magnesium deficiency, heart failure and myocardial infarction in adults, children, as well as during pregnancy and lactation.

Panangin is a drug that affects metabolic processes. Source of potassium and magnesium ions.

Potassium and magnesium are intracellular cations that play a major role in the functioning of many enzymes, the interaction of macromolecules and intracellular structures, and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, magnesium, calcium and sodium ions affects myocardial contractility. A low level of potassium and/or magnesium ions in the internal environment can have a proarrhythmogenic effect, predisposing to the development of arterial hypertension, atherosclerosis of the coronary arteries and the occurrence of metabolic changes in the myocardium.

One of the most important physiological functions of potassium is maintaining the membrane potential of neurons, myocytes and other excitable structures of myocardial tissue. An imbalance between the intra- and extracellular potassium content leads to a decrease in myocardial contractility, the occurrence of arrhythmia, tachycardia and increased toxicity of cardiac glycosides.

Magnesium is a cofactor in more than 300 enzymatic reactions in energy metabolism and the synthesis of proteins and nucleic acids. Magnesium reduces contractile tension and heart rate, leading to a decrease in myocardial oxygen demand. Magnesium has an anti-ischemic effect on myocardial tissue. Decreased contractility of smooth muscle myocytes in the walls of arterioles, incl. coronary, leads to vasodilation and increased coronary blood flow.

The combination of potassium and magnesium ions in one preparation is justified by the fact that potassium deficiency in the body is often accompanied by magnesium deficiency and requires simultaneous correction of the content of both ions in the body. With simultaneous correction of the levels of these electrolytes, an additive effect is observed, in addition, potassium and magnesium reduce the toxicity of cardiac glycosides without affecting their positive inotropic effect.

When taken orally, absorption of the drug is high. Excreted in urine.

Data on the pharmacokinetics of the drug in the form of a solution for intravenous administration are not provided.

as part of complex therapy for heart failure, myocardial infarction, cardiac arrhythmias (mainly ventricular arrhythmias);
to improve the tolerability of cardiac glycosides;
replenishment of potassium and magnesium deficiency when their content in the diet is reduced (for tablets).

Film-coated tablets.

Solution for intravenous administration (in ampoules for injection).

Instructions for use and dosage

For oral administration

Prescribe 1-2 tablets 3 times a day. The maximum daily dose is 3 tablets 3 times a day.

The drug should be used after meals, because the acidic environment of the stomach contents reduces its effectiveness.

The duration of therapy and the need for repeated courses are determined by the doctor individually.

For intravenous administration

The drug is prescribed intravenously (in a dropper), as a slow infusion. A single dose of ampoules, if necessary, repeated administration after 4-6 hours is possible.

To prepare a solution for intravenous infusion, the contents of 1-2 amps. dissolve in 5% glucose solution.

paresthesia (caused by hyperkalemia);
hyporeflexia;
convulsions (due to hypermagnesemia);
AV block;
paradoxical reaction (increased number of extrasystoles);
decrease in blood pressure;
redness of the facial skin (due to hypermagnesemia);
nausea, vomiting;
diarrhea (including those caused by hyperkalemia);
a feeling of discomfort or burning in the pancreas (in patients with anacid gastritis or cholecystitis);
respiratory depression (due to hypermagnesemia);
feeling of heat (due to hypermagnesemia);
with rapid intravenous administration, symptoms of hyperkalemia and/or hypermagnesemia may develop.

For oral and intravenous administration

oliguria, anuria;
Addison's disease;
2nd and 3rd degree AV block;
cardiogenic shock (BP<90 мм рт.ст.);
hyperkalemia;
hypermagnesemia;

For oral administration

myasthenia gravis;
1st degree AV block;
hemolysis;
violation of amino acid metabolism;
acute metabolic acidosis;
dehydration of the body.

Use during pregnancy and breastfeeding

There are no data on the negative effects of the drug in the form of a solution for intravenous administration during pregnancy and lactation (breastfeeding).

The drug should be used orally with caution during pregnancy (especially in the 1st trimester) and during lactation (breastfeeding).

The drug should be prescribed with caution to patients with an increased risk of developing hyperkalemia. In this case, it is necessary to regularly monitor the level of potassium ions in the blood plasma.

Before taking the drug, the patient should consult a doctor.

With rapid intravenous administration of the drug, skin hyperemia may develop.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive a car or engage in activities that require increased concentration and speed of psychomotor reactions.

When used simultaneously with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, ACE inhibitors, NSAIDs, the risk of developing hyperkalemia up to the appearance of arrhythmia and asystole increases. The use of potassium supplements together with corticosteroids eliminates the hypokalemia they cause. Under the influence of potassium, a decrease in the undesirable effects of cardiac glycosides is observed.

The drug enhances the negative dromo- and bathmotropic effects of antiarrhythmic drugs.

Due to the presence of potassium ions in the drug, when Panangin is used with ACE inhibitors, beta-blockers, cyclosporine, potassium-sparing diuretics, heparin, NSAIDs, the development of hyperkalemia is possible (monitoring the level of potassium in the blood plasma is necessary); with anticholinergic drugs - a more pronounced decrease in intestinal motility; with cardiac glycosides - a decrease in their effect.

Magnesium preparations reduce the effectiveness of neomycin, polymyxin B, tetracycline and streptomycin.

Anesthetics enhance the inhibitory effect of magnesium on the central nervous system. When used with atracurium, dexamethonium, suxamethonium, neuromuscular blockade may be enhanced; with calcitriol - increasing the level of magnesium in the blood plasma; with calcium supplements, a decrease in the effect of magnesium ions is observed.

When Panangin is used simultaneously with potassium-sparing diuretics and ACE inhibitors, the risk of developing hyperkalemia increases (the level of potassium in plasma should be monitored).

Analogues of the drug Panangin

Structural analogues of the active substance:

Panangin instructions for use dropper

Panangin has an international name: Potassium and magnesium aspartate. Not to be confused with Aspartate and Aspartame.

This is a solution for intravenous administration.

It regulates metabolic processes and promotes the restoration of electrolyte balance, and produces an antiarrhythmic effect. The positive potassium ion takes part in the conduction of impulses along nerve fibers, in synaptic transmission, in muscle contractions, and in maintaining the tone of cardiac activity. On the contrary, distortion of K+ metabolism leads to changes in the excitability of nerves and muscles. K+ has the ability to dilate arteries in small doses, and to narrow them in large doses. And Mg2+ is a concomitant factor in three hundred enzyme reactions. Takes an active part in the processes of energy intake and expenditure, in the balance of electrolytes, ion transport, membrane permeability and neuromuscular excitability.

Panagin is prescribed as a solution for a dropper in case of a dangerous decrease in potassium and magnesium ions in the blood, including those arising from vomiting and diarrhea. When treated with saluretics, corticosteroids and laxatives, a similar effect may also occur, accompanied by arrhythmias due to digitalis intoxication or myocardial infarction.

Contraindication to the use of panangin as a solution for drip

Contraindications, of course, include individual intolerance, including to sorbitol and fructose, amino acid metabolism disorders, acute and chronic renal failure, adrenal insufficiency, arterial hypotension, dehydration; hemolysis; Addison's disease; metabolic acidosis.

Panangin should be taken with caution during pregnancy, especially in the first trimester and lactation.

It is administered intravenously slowly or by drip. To carry out slow intravenous jet administration, an injection solution is made; for this purpose, up to twenty milliliters of the solution is diluted in ten milliliters of 0.9% NaCl solution, or in the same volume of 5% dextrose solution; apply twice a day.

Panangin solution - official instructions for use

Registration number: P N013093/01

Trade name: Panangin

International nonproprietary or generic name: Potassium aspartate + Magnesium aspartate &

Dosage form: concentrate for the preparation of solution for infusion.

Composition per ampoule:

Active ingredients: Potassium aspartate (in the form of potassium aspartate hemihydrate) 452 mg (corresponding to 103.3 mg of potassium ions), magnesium aspartate (in the form of magnesium aspartate tetrahydrate) 400 mg (corresponding to 33.7 mg of magnesium ions);

Excipients: water for injection – up to 10 ml.

Description: Colorless or slightly greenish, transparent solution.

Pharmacotherapeutic group: potassium and magnesium preparation.

Pharmacological properties

Panangin is a source of important electrolytes: potassium and magnesium ions. One of the most important functions of potassium ions is to maintain the membrane potential of neurons, myocytes and excitable structures of myocardial tissue. An imbalance between intracellular and extracellular potassium leads to a decrease in cardiac contractility, arrhythmia, tachycardia and increased toxicity of cardiac glycosides.

Magnesium is an important cofactor in more than 300 enzyme reactions, including energy metabolism and the synthesis of proteins and nucleic acids. In addition, magnesium plays an important role in the functioning of the heart: it improves contractility and heart rate, leading to a decrease in myocardial oxygen demand. A decrease in the contractility of smooth myocytes of arterioles leads to vasodilation, including of the coronary vessels, and to increased coronary blood flow. Magnesium has an anti-ischemic effect on myocardial tissue.

The combination of potassium and magnesium ions in one preparation is based on the fact that potassium deficiency in the body is often accompanied by magnesium deficiency and requires simultaneous correction of the levels of both ions. Further, with simultaneous correction of the levels of these electrolytes, an additive effect is observed (low levels of potassium and/or magnesium have a proarrhythmogenic effect), in addition, potassium and magnesium reduce the toxicity of cardiac glycosides without affecting the positive inotropic effect of the latter.

Indications

To eliminate potassium and magnesium deficiency as an adjuvant for various manifestations of coronary heart disease, including acute myocardial infarction; chronic heart failure; heart rhythm disturbances (including arrhythmias caused by an overdose of cardiac glycosides).

Contraindications

Hypersensitivity to the drug, acute and chronic renal failure; Addison's disease; atrioventricular block II, III degree; cardiogenic shock (blood pressure Use caution

First degree atrioventricular block, severe liver dysfunction; metabolic acidosis; risk of edema; impaired renal function if regular monitoring of the magnesium content in the blood serum is impossible (danger of accumulation, toxic magnesium content); cardiogenic shock (systolic blood pressure less than 90 mm Hg); hypophosphatemia; urolithiasis associated with impaired metabolism of calcium, magnesium and ammonium phosphate.

Pregnancy and lactation

There is no data on the harmful effects of the drug during pregnancy.

Directions for use and doses

For intravenous administration only.

The contents of 1-2 ampoules should be diluted with a 5% dextrose (glucose) solution and administered intravenously as a slow drip infusion (20 drops per minute). If necessary, the dose can be repeated after 4-6 hours.

The drug is suitable for combination therapy.

Side effect

With rapid intravenous administration, symptoms of hyperkalemia (fatigue, myasthenia gravis, paresthesia, confusion, cardiac arrhythmia (bradycardia, atrioventricular block, arrhythmias, cardiac arrest) and hypermagnesemia (decrease in neuromuscular excitability, retching, vomiting, lethargy, decreased blood pressure) may develop. It is also possible to develop phlebitis, atrioventricular block and a paradoxical reaction (increased number of extrasystoles).

Overdose

To date, cases of overdose have not been described. In case of overdose, the risk of symptoms of hyperkalemia and hypermagnesemia increases.

Symptoms of hyperkalemia: fatigue, myasthenia gravis, paresthesia, confusion, cardiac arrhythmia (bradycardia, atrioventricular block, arrhythmias, cardiac arrest).

Symptoms of hypermagnesemia: decreased neuromuscular excitability, retching, vomiting, lethargy, decreased blood pressure (BP). With a sharp increase in the content of magnesium ions in the blood - depression of deep tendon reflexes, respiratory paralysis, coma.

Treatment: If symptoms of overdose occur, treatment with Panangin should be stopped and symptomatic therapy (intravenous administration of calcium chloride at a dose of 100 mg/min, hemodialysis if necessary).

Interaction with other drugs

Strengthens the negative dromo- and bathmotropic effect of antiarrhythmic drugs.

Eliminates hypokalemia caused by glucocorticoids.

Anesthetics enhance the inhibitory effect of magnesium on the central nervous system.

May enhance neuromuscular blockade caused by depolarizing muscle relaxants (atracurium besylate, decamethonium bromide, suxamethonium (chloride, bromide, iodide)).

Calcitriol increases the concentration of magnesium in the blood plasma, calcium preparations reduce the effect of magnesium.

Beta-blockers and non-steroidal anti-inflammatory drugs increase the risk of developing hyperkalemia up to the development of arrhythmia and asystole.

Pharmaceutically compatible with solutions of cardiac glycosides (improves their tolerability, reduces the undesirable effects of cardiac glycosides).

special instructions

With rapid administration, skin hyperemia may develop.

Particular caution should be exercised in the presence of diseases accompanied by hyperkalemia. In these cases, it is recommended to monitor the content of potassium ions in the blood.

The effect of the drug on the ability to drive vehicles and machinery

Release form

Concentrate for solution for infusion, 45.2 mg/ml +40 mg/ml.

10 ml of the drug in a colorless glass ampoule (hydrolytic class 1), 5 ampoules in a plastic tray. 1 plastic pallet in a cardboard box with instructions for medical use.

Storage conditions

Store at temperatures from 15 to 30 °C.

Keep out of the reach of children!

Best before date

Should not be used after the expiration date.

Vacation conditions

Manufacturer:

JSC "Gedeon Richter"

1103 Budapest, st. Dymroyi 19-21, Hungary

Consumer complaints should be sent to:

Moscow Representative Office of JSC Gedeon Richter

Moscow, 4th Dobryninsky lane, building 8.

Panangin

Instructions for use:

Prices in online pharmacies:

Panangin is a drug that replenishes the deficiency of potassium and magnesium in the body.

pharmachologic effect

The main active ingredients of Panangin are magnesium aspartate and potassium aspartate.

Magnesium and potassium are intracellular cations that play a significant role in the interaction of intracellular structures and macromolecules, in the functioning of many enzymes and the mechanism of muscle contractility. A low level of these ions in the internal environment can cause metabolic changes in the myocardium, have a proarrhythmogenic effect (cause arrhythmia), and lead to the development of arterial hypertension.

Aspartate not only acts as a carrier of magnesium and potassium ions, but also promotes their penetration into the intracellular space.

The combination of magnesium and potassium ions in the Panangin preparation is due to the fact that potassium deficiency in the body is usually accompanied by magnesium deficiency, and therefore correction of the content of these ions requires simultaneous correction.

Release form

Panangin is produced in the form:

film-coated tablets, 50 pcs. in bottles packed in cardboard boxes;
solution for intravenous administration, 5 ampoules (10 ml) in contour plastic containers, packed in cardboard packs.

Indications for use of Panangin

The instructions indicate the following indications for Panangin:

condition after myocardial infarction;
heart rhythm disturbances (as part of complex therapy);
chronic heart disease;
treatment with cardiac glycosides (in complex therapy);
replacement therapy for potassium/magnesium deficiency.

Contraindications to the use of Panangin

According to the instructions, Panangin in tablet form is contraindicated for use in diseases and conditions such as:

violation of amino acid metabolism;
AV block of the first degree;
myasthenia gravis;
dehydration of the body;
acute metabolic acidosis;
hemolysis.

Panangin is not prescribed for oral administration and in the form of intravenous infusion for the following diseases and conditions:

acute and chronic renal failure;
hypermagnesemia;
hyperkalemia;
AV block II and III degrees;
cardiogenic shock (BP< 90 мм ртутного столба);
Addison's disease;
oliguria;
anuria;
hypersensitivity to the components of the drug.

Panangin is prescribed with caution for oral use during pregnancy and lactation, and intravenously for first-degree AV blockade.

Panangin instructions: methods of use and dosage

Tablets are prescribed in 1-2 pieces. three times a day. They should be taken only after meals (this is due to the fact that the acidic gastric environment reduces the effectiveness of the drug).

The maximum daily dose should not exceed 9 tablets, i.e. 3 tablets three times a day.

The duration of treatment and the need for repeated courses of therapy are determined by the attending physician individually, taking into account the indications for Panangin.

The solution is administered intravenously. A single dose is 1-2 ampoules. To prepare an infusion solution, the contents of the ampoules are dissolved in a 5% glucose solution (ml).

If necessary, repeated administration is possible after 4-6 hours.

Drug overdose

In case of an overdose of tablets, cardiac conduction may be impaired; in case of an overdose of the solution, hyperkalemia and hypermagnesemia may develop. In such cases, you should stop taking Panangin and carry out symptomatic therapy, and possibly even hemodialysis.

Side effects from using Panangin

Panangin, patient reviews confirm this, may cause some side effects.

With rapid intravenous administration, symptoms of hypermagnesemia and/or hyperkalemia may develop.

According to reviews of Panangin, taking pills can provoke:

from the cardiovascular system: decreased blood pressure, paradoxical reaction, AV block;
from the central nervous system and peripheral nervous system: paresthesia, convulsions, hyporeflexia;
from the gastrointestinal tract: vomiting, nausea, diarrhea, discomfort in the pancreas;
from the respiratory system: respiratory depression.

special instructions

The use of Panangin is possible only as prescribed by a doctor.

Panangin, reviews confirm this, does not affect the ability to drive a vehicle or engage in any activity that requires speed of psychomotor reactions and concentration.

Rules for storage and dispensing from pharmacies

Panangin tablets are sold in pharmacies without a prescription, the solution is strictly according to the prescription.

The drug should be stored in a place protected from the sun at a temperature of about C.

The shelf life of the tablets is 5 years, the solution – 3 years.

Panangin tab. p/o captivity. No. 50

Panangin tablets 50 pcs.

Panangin conc.d/inf. 10ml n5

Panangin solution 10 ml 5 pcs.

Panangin injection solution 10ml No. 5 ampoules

Panangin No. 50 tablets

Panangin N50 tablet

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Panangin - instructions and price

ATX code: A12CX
Release form: tablets, solution

Introduction to instructions for use

1. Pharmacological action

2. indications for use

Heart rhythm disturbances caused by various reasons (ion balance disorders, poisoning with glycoside drugs);

3. Method of application

Panangin in the form of dragees:

In severe cases: the first 3 weeks of treatment - three doses per day, 3 tablets each, then the dose is reduced to 2-3 doses per day, 1 tablet each;

The duration of treatment is determined by the attending physician.

For intravenous jet infusions: 1 ml ampoule of saline or glucose solution;

4. Side effects

5. Contraindications

Functional kidney failure in acute and chronic forms;

6. During pregnancy and lactation

7. Interaction with other drugs

With the simultaneous use of Panangin with drugs that block the ACE enzyme or adrenaline receptors, Cyclosporine, Heparin, calcium-sparing diuretics, non-steroidal anti-inflammatory drugs, the risk of increasing the content of calcium ions in the blood increases;

8. Overdose

Increased content of calcium and magnesium ions in the blood (with intravenous administration of the drug);

If overdose symptoms occur, immediately discontinue the drug and administer intravenous saline at a dosage of 100 mg per minute. In especially severe cases, mechanical blood purification (dialysis) is performed.

9. Release form

Solution, 452 mg+400 mg/10 ml - amp. 5 pieces.

10. Storage conditions

11. Composition

In 1 tablet of Panangin:

potassium aspartate hemihydrate - 166.3 mg;

1 ml solution:

potassium aspartate (in the form of hemihydrate) - 42.5 mg;

12. Conditions for dispensing from pharmacies

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Indications for use of panangin

The health of the body, the work, and the “interaction” of organs depend on many factors. The most important thing is the balance of trace elements and minerals. Magnesium and potassium take an active part in “debugging” the activity of blood vessels and the heart. By promoting myocardial metabolism and improving the metabolic processes of the heart, they protect a person from heart attacks, arrhythmias, tachycardia and other diseases. The body receives these substances from the outside - with food or as a result of taking special medications: asparkam or panangin. What is good about the latter, what are the indications for use of the medicine Panangin?

Composition and release form

It is a drug designed to compensate for the deficiency of magnesium and potassium in the body. Consists of two active substances:

potassium aspartate – about 160 mg;
magnesium aspartate – 140 mg.

Pharmaceutical companies produce:

Panangin for oral use is sold in cardboard packaging. 50 tablets, for protection from sunlight, are placed in one dense polypropylene (plastic) bottle. Glass ampoules containing a drug solution are sorted into 5 pieces. on a pallet. The packaging of liquid panangin includes 5 ampoules of 10 ml each..

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Panangin - what does the medicine help with?

What is the mechanism of action of panangin when the patient has indications for using the medicine? Microelements necessary for the normal functioning of the cardiovascular system perform the following functions:

Stimulate myocardial function, increasing cardiac conduction of impulses.
Strengthen the walls of blood vessels, reducing muscle tone and increasing blood flow.
Normalizes heart rate.
Participate in the metabolic processes of the heart, relieve swelling and spasms of internal organs.

For preventive purposes, cardiologists prescribe panangin to patients:

when there is a threat of ischemia;
after a heart attack;
people suffering from heart pain, swelling;
for heart failure, arrhythmias;
high blood pressure, hypertension.

Indications for the use of panangin are constant spasms and pain in the leg muscles. The lack of active substances leads to a “squeezed” state of the muscular system and constant contraction. Intense physical activity, mental work, stressful situations are prerequisites for potassium and magnesium deficiency. Taking medication in these cases increases performance and increases resistance to stress.

The inclusion of Mg and K in the composition of the drug is due to a simultaneous deficiency of these microelements in the body. Potassium and magnesium ions in combination create additive synergism, when each substance exhibits an effect separately, enhancing the effect of the “companion”. Indications for the use of the drug are to reduce the toxicity of cardiac glycosides without affecting the positive effect.

Instructions for use of the drug

The tablet (capsule) form is highly absorbent and is excreted from the body in the urine. In some cases, doctors determine indications for the simultaneous use of cardiac glycosides and panangin. Increased load on the kidneys becomes a contraindication for diseases of the latter. Pharmacokinetics following intravenous injection are unknown.

Pills

Panangin is taken after meals. Increased stomach acidity reduces the absorption of active substances, slowing down the effectiveness of the effect. The duration of treatment and the need for re-appointment are determined by the doctor. Indications for use are as follows:

General cases – 1 – 2 capsules 3 times throughout the day at equal intervals.
In case of impaired coronary circulation, immunity to digitalis preparations, intolerance - 3 capsules three times a day after meals. Gradually, under the supervision of a doctor, the dosage is reduced.

Injection

Acute cases are an indication for the use of the liquid form of panangin. 10 ml of solution for injection is diluted with 20 - 40 ml of isotonic sodium chloride or 5% glucose. The drug is administered by injection very slowly and gradually, so as not to cause signs of hyperkalemia, hypermagnesemia: nausea, gag reflexes, dizziness.

For patients with hypersensitivity to potassium and magnesium, doctors prescribe IVs. Two ampoules of the medicine are diluted with 0.3 - 0.5 liters of saline solution (0.9% aqueous NaCl solution) or a five percent dextrose solution. Then they are administered to the patient by drip. Time interval between injections: hours. It is possible to use the medicine as a component of complex therapy.

Contraindications to the use of the drug

The absence of indications for the prescription and use of Panangin are:

Heart failure (acute).
Chronic kidney disease, acute failure.
Intolerance to the components of the drug.
Alcoholism.
Confusion, increased fatigue, myasthenia gravis, parasthesia are signs of hyperkalemia.
Dehydration.
Stably low blood pressure, cases of cardiogenic shock.
Low muscle excitability, difficulty breathing, dizziness, nausea are symptoms of hypermagnesemia.

Caution: Panangin is prescribed only under the supervision of a doctor to patients with cardiac muscle conduction pathology. A burning sensation or discomfort in the epidural area is a reason to reduce the dosage of the medication. Panangin is not recommended for use by women in the first trimester of pregnancy when breastfeeding.

Drug interactions and overdose

Overdose has not been clinically documented. The theoretical consequences are the appearance and intensification of symptoms of oversaturation of the body with magnesium and potassium: nausea, constipation or diarrhea, muscle cramps, lethargy, dehydration. Such cases require:

Refusal to use.
Administration of saline solution (300 ml).
Particularly severe intoxications – hemodialysis.

When complex treatment with several drugs, it is necessary to take into account the peculiarities of their interaction:

Adrenergic blockers, diuretics spironolactone and triamterene, cyclosparin, heparin, inhibitors and non-steroidal anti-inflammatory drugs - cause an excess of K and Mg in the body with inherent symptoms.
Panangin reduces the effect of streptomycin, tetracycline, neomycin.
Calcium-containing medications sharply reduce the effect of using magic.
Anesthetics - together with Mg, suppress the nervous excitability of the central nervous system.
The positive effect of using panangin when indicated is the compatibility of the solution and cardiac glycosides, the side effects of which are neutralized.

Approximate cost of Panangin in tablets and ampoules

You can purchase panangin in regular and online pharmacies in Russia. The price of the drug varies by region of the country. So, if you want to buy the drug in Moscow, the cost will be from 120 to 155 rubles. for tablets and about 160 - 165 rubles for a solution for intravenous administration. The average price of panangin is about 130 - 140 rubles. in the form of capsules and 160 - 166 rubles per package of ampoules.

Analogues of the drug Panangin

What is the difference between Panangin and Asparkam, Aspangin - domestic analogues? Panangin is an original drug, more purified. Asparkam is an analogue (copy) of this medicine. Tablets of the drug, coated with a protective coating, protect the gastrointestinal tract from negative effects, so people suffering from colitis, ulcers and gastritis should give it preference.

The price indications of the drugs also differ: being a copy, asparkam and aspangin cost two to three times less than the original. Most people who have indications for the use of drugs that replenish K and Mg deficiency give preference to panangin due to its noticeable effect on the heart muscle, leg muscles, and a reduction in the manifestations of varicose veins.

Panangin is an ionic combination drug that contains potassium and magnesium. Panangin has an antiarrhythmic effect, improves the conduction of nerve impulses through the conduction system of the heart and normalizes its rhythm by restoring the balance of magnesium and potassium ions in the myocardium. Has a preventive effect and reduces the risk of developing atherosclerosis and myocardial infarction. Used as part of combination therapy in the treatment of chronic heart diseases, as well as in the treatment of cardiac glycosides, as well as to relieve attacks of ventricular arrhythmia.

1. Pharmacological action

Panangin actively transports potassium and magnesium ions inside the cell, which are then included in metabolic processes and have a healing effect on the heart muscle.

Absorption of Panangin occurs quite quickly, excretion occurs through the kidneys.

2. indications for use

Heart rhythm disturbances caused by various reasons (ion balance disorders, poisoning with glycoside drugs);
Rhythm disturbances in various parts of the heart;
Insufficiency of the arteries of the heart;
Violation of cardiac circulation.

3. Method of application

Panangin in the form of dragees:

Panangin is used after meals in the following dosage:

In severe cases: the first 3 weeks of treatment - three doses per day, 3 tablets each, then the dose is reduced to 2-3 doses per day, 1 tablet each;
In relatively mild cases: 2-3 doses per day, 1 tablet.

The duration of treatment is determined by the attending physician.

Panangin in the form of a solution for injection:

Used to quickly relieve attacks of arrhythmia for intravenous injection by jet or drip methods. Before use, the drug is diluted in the following dosage:

For intravenous jet infusions: 1 ampoule in 20-30 ml of saline or glucose solution;
For intravenous drip administration: 2 ampoules in 250-500 ml of saline or glucose solution.

Both methods of administration must occur fairly slowly. The number of injections is determined by the attending physician depending on the patient's condition.

4. Side effects

When Panangin is administered into a vein, nausea or dizziness may occur. In these cases, the dose of the drug should be reduced.

5. Contraindications

Functional kidney failure in acute and chronic forms;
Increased content of calcium ions in the blood;
Individual intolerance to Panangin or its components;
Increased content of potassium ions in the blood;
Hypersensitivity to Panangin or its components;
First trimester of pregnancy;
Disorders of the conduction system of the heart (blockade of one of the nerve nodes).

6. During pregnancy and lactation

Use of Panangin in the first trimester of pregnancy contraindicated. In the future, the drug is used only in special cases when the therapeutic effect of treatment far exceeds the expected harm. The use of Panangin during lactation should be accompanied by mandatory cessation of breastfeeding throughout the entire duration of treatment.

7. Interaction with other drugs

With the simultaneous use of Panangin with drugs that block the ACE enzyme or adrenaline receptors, Cyclosporine, Heparin, calcium-sparing diuretics, non-steroidal anti-inflammatory drugs, the risk of increasing the content of calcium ions in the blood increases;
Simultaneous use with drugs that block acetylcholine leads to a decrease in natural intestinal fluctuations;
Simultaneous use with painkillers increases the inhibitory effect of magnesium ions on the central nervous system;
Simultaneous use with cardiac glycosides leads to a decrease in the therapeutic effect of the latter;
Simultaneous use with Tetracycline and Streptomycin leads to a decrease in the therapeutic effect of the latter;
With the simultaneous use of Panangin with potassium-sparing diuretics and drugs that have a blocking effect on the ACE enzyme, the risk of increased levels of potassium ions in the blood increases.

8. Overdose

Increased content of calcium and magnesium ions in the blood (with intravenous administration of the drug);
Disorders of the conduction system of the heart (when taking Panangin in the form of tablets).

9. Release form

Tablets, 158 mg+140 mg - 50 pcs.
Solution, 452 mg+400 mg/10 ml - amp. 5 pieces.

10. Storage conditions

Panangin is stored in a dry place without access to light. The recommended temperature is no more than 25 degrees.

11. Composition

In 1 tablet of Panangin:

potassium aspartate hemihydrate - 166.3 mg;
which corresponds to the content of potassium aspartate - 158 mg;
magnesium aspartate tetrahydrate - 175 mg;
which corresponds to the content of magnesium aspartate - 140 mg;
Excipients: colloidal silicon dioxide, povidone, magnesium stearate, talc, corn starch, potato starch.

1 ml solution:

potassium aspartate (in the form of hemihydrate) - 42.5 mg;
which corresponds to the K+ content - 10.33 mg;
magnesium aspartate (in the form of tetrahydrate) - 40 mg;
which corresponds to the Mg2+ content - 3.37 mg;
Excipients: water.

12. Conditions for dispensing from pharmacies

The drug is available without a prescription.

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* Instructions for medical use of the drug Panangin are published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, YOU MUST CONSULT WITH A SPECIALIST

The drug Panangin belongs to the group of mineral agents that can have a protective effect on myocardial muscle fibers. When taken correctly, it helps prevent heart rhythm disturbances and the development of ischemic tissue damage due to oxygen starvation.

Helps eliminate the phenomena of heart failure and improper polarization of ions involved in energy metabolism. Use is indicated for confirmed deficiency of potassium and magnesium salts in the blood plasma.

Available in the form of tablets and solution for intravenous administration. The active ingredients are potassium aspartate and magnesium aspartate.

When introduced into the body either in tablet or infusion form, panangin is quickly absorbed into the blood and enriches it with potassium and magnesium ions. The importance of potassium for the health of the heart muscle cannot be overestimated. This microelement is responsible for the conduction of nerve impulses and the normalization of the membrane membranes of myocardiocytes and neurons. Thanks to this, a sufficient amount of potassium in the blood plasma is able to maintain the energy balance of the myocardium at a high level. In practice, this is expressed in the absence of rhythm disturbances and oxygen deficiency in oxidative processes. In patients with heart failure and in the period after acute myocardial infarction, potassium, which comes from food components, is not absorbed properly. A large number of extracellular forms of this substance arise. They gradually attract more and more potassium ions from the intracellular space, which stimulates the deterioration of the clinical picture. Intravenous administration of panangin in such cases helps eliminate this imbalance and restore metabolic processes in the myocardium.

The human body needs magnesium for the synthesis of various amino acids, on the basis of which proteins and cellular structures are built. This microelement is involved in various reactions in the production of enzymatic substances. When penetrating the myocytes of the heart muscle, magnesium reduces the number of contractions and has the ability to restore normal rhythm. There is also an effect aimed at reducing the phenomena of oxygen starvation and ischemia of muscle tissue. This also affects the smooth muscles of various blood vessels. Gradually, they dilate and restore normal blood flow.

Panangin solution and tablets - instructions for use

Panangin tablets are prescribed for oral administration. The duration of the course of treatment depends on the severity of the patient’s condition and can range from 15 days to 2-3 months. The drug should be taken after meals. This is necessary to reduce the risk of hydrochloric acid affecting the tablet shell.

The instructions for use recommend using Panangin solution for the preparation of mixtures for intravenous drip infusions. But you can also give intravenous injections. To do this, the panangin solution is diluted with saline in a ratio of 5 ml of panangin and 10 ml of 0.9% isotonic solution.

The preferred method is slow drip administration. In this case, the sick person should be in a supine position. Thus, more complete absorption of minerals is achieved.

What are Panangin's indications for use?

Treatment of any disease that requires the administration of panangin usually begins with intravenous administration of the drug. Injections are given every other day in an amount of 5 pieces. In the future, the patient is recommended to continue therapy with Panangin tablets.

Main indications for the use of panangin:

long-term maintenance and replacement therapy with cardiac glycosides;
arrhythmias of ventricular and atrial type;
weakness of the sinus node;
heart rate driver dissonance;
cardiovascular failure in acute and chronic form;
recovery period after myocardial infarction;
cardiac ischemia;
mineral deficiency.

Can Panangin be used during pregnancy and children?

It is recommended to use panangin during pregnancy if a woman has insufficient intake of microelements from her diet. Magnesium deficiency can manifest itself in the form of cramps in the calf muscles, discomfort in the heart and swelling of the ankle joints in the morning.

The drug Panangin is prescribed to children in similar cases. In the newborn period, indications for use may be insufficiency of the cardiac pacemaker function and increased convulsive readiness.

Pregnancy, breastfeeding and childhood are not contraindications for treatment with this pharmacological agent.

What are the contraindications and side effects?

Side effects can only occur if there is an excess amount of potassium and magnesium ions in the body of a sick person. In this case, complete withdrawal of the drug is sufficient to ensure that all unpleasant symptoms are eliminated.

The following diseases and conditions may be contraindications for the use of solution and tablets:

individual intolerance to individual components;
dysfunction of the urinary system;
blockade of the heart muscle and pacemakers;
states of shock;
increased content of potassium and magnesium ions in the blood and plasma;
dehydration and severe intoxication.

How to take Panangin? Approximate dosages
Adults - intravenous injections	20 ml per day for 5 - 10 days
Adults - tablets	1 - 2 tablets 3 times a day for 3 - 4 weeks
Children - intravenous injections	Only drip administration of 10 ml of panangin diluted in 100 ml of glucose in the form of a 5% solution is allowed
Children - tablets	Depending on age 1/2 - 1 tablet 2 - 3 times a day

What analogues of panangin exist?

The only analogue of panangin is asparkam. Both drugs have identical composition to each other. However, for intravenous administration it is recommended to give preference to panangin, since asparkam is somewhat more difficult to tolerate in patients with weak heart muscles.

In tablet form, no significant differences were found between taking panangin and asparkam.

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In this article you can read the instructions for use of the drug Panangin.

Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Panangin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Panangin in the presence of existing structural analogues. Use for the treatment of potassium and magnesium deficiency, heart failure and myocardial infarction in adults, children, as well as during pregnancy and lactation.

Solution for intravenous administration (in ampoules for injection).

For oral administration

For intravenous administration

To prepare a solution for intravenous infusion, the contents of 1-2 amps. dissolve in 5% glucose solution.

hyporeflexia;
AV block;
decrease in blood pressure;
nausea, vomiting;

oliguria, anuria;
Addison's disease;
2nd and 3rd degree AV block;
cardiogenic shock (BP<90 мм рт.ст.);
hyperkalemia;
hypermagnesemia;

For oral administration

myasthenia gravis;
1st degree AV block;
hemolysis;
violation of amino acid metabolism;
acute metabolic acidosis;
dehydration of the body.

There are no data on the negative effects of the drug in the form of a solution for intravenous administration during pregnancy and lactation (breastfeeding).

Panangin for children

The drug "Panangin", produced by the company "Gedeon Richter", is intended for the correction of disorders caused by a lack of magnesium and potassium. More often, this medication is prescribed in cardiological practice to adults for arrhythmia or heart failure. Is it possible to use the product in childhood, what dosage is acceptable: let’s figure it out together.

Composition and dosage form

Panangin is produced in the form of tablets and injections. Both versions of the drug contain magnesium as active ingredients (in the form of aspartate in a dose of 140 mg in 1 tablet and 400 mg in 1 ampoule) and potassium (similarly in the form of aspartate in an amount of 158 mg in each tablet and 452 mg in each ampoule). The tablets have a coating that prevents the premature destruction of magnesium and potassium salts in the stomach. It is made from copolymers, talc, macrogol and titanium dioxide. The inside of the tablet includes starch, povidone and some other substances.

Panangin in tablet form is round in shape and white in color. This drug is sold in bottles of 50 tablets. An auxiliary ingredient in the solution for injections is sterile water. This medicine is colorless (transparent), sometimes slightly greenish. It is usually packaged in clear glass ampoules of 10 ml. One box contains 5 ampoules.

Panangin (tablets, injections in ampoules for injection in solution) - instructions for use, analogs, reviews, side effects of the drug and indications for the treatment of potassium and magnesium deficiency, heart failure in adults and children

The page provides instructions for using Panangin. It is available in various dosage forms of the drug (tablets, injections in ampoules for injection in solution), and also has a number of analogues. This abstract has been verified by experts. Leave your feedback on the use of Panangin, which will help other site visitors. The drug is used for various diseases (potassium and magnesium deficiency, heart failure, arrhythmia). The product has a number of side effects and interactions with other substances. Doses of the drug differ for adults and children. There are restrictions on the use of the medicine during pregnancy and breastfeeding. Treatment with Panangin can only be prescribed by a qualified doctor. The duration of therapy may vary and depends on the specific disease.

Instructions for use and dosage

For oral administration

Prescribe 1-2 tablets 3 times a day. The maximum daily dose is 3 tablets 3 times a day.

The drug should be used after meals, because the acidic environment of the stomach contents reduces its effectiveness.

The duration of therapy and the need for repeated courses are determined by the doctor individually.

For intravenous administration

The drug is prescribed intravenously (in a dropper), as a slow infusion. A single dose of ampoules, if necessary, repeated administration after 4-6 hours is possible.

To prepare a solution for intravenous infusion, the contents of 1-2 ampoules are dissolved in 5% glucose solution.

Film-coated tablets.

Solution for intravenous administration (injections in injection ampoules).

Panangin is a drug that affects metabolic processes. Source of potassium and magnesium ions.

When taken orally, absorption of the drug is high. Excreted in urine.

Data on the pharmacokinetics of the drug in the form of a solution for intravenous administration are not provided.

as part of complex therapy for heart failure, myocardial infarction, cardiac arrhythmias (mainly ventricular arrhythmias);
to improve the tolerability of cardiac glycosides;
replenishment of potassium and magnesium deficiency when their content in the diet is reduced (for tablets).

For oral and intravenous administration

acute and chronic renal failure;
oliguria, anuria;
Addison's disease;
2nd and 3rd degree AV block;
cardiogenic shock (BP<90 мм рт.ст.);
hyperkalemia;
hypermagnesemia;
hypersensitivity to the components of the drug.

For oral administration

myasthenia gravis;
1st degree AV block;
hemolysis;
violation of amino acid metabolism;
acute metabolic acidosis;
dehydration of the body.

Before taking the drug, the patient should consult a doctor.

With rapid intravenous administration of the drug, skin hyperemia may develop.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive a car or engage in activities that require increased concentration and speed of psychomotor reactions.

paresthesia (caused by hyperkalemia);
hyporeflexia;
convulsions (due to hypermagnesemia);
AV block;
paradoxical reaction (increased number of extrasystoles);
decrease in blood pressure;
redness of the facial skin (due to hypermagnesemia);
nausea, vomiting;
diarrhea (including those caused by hyperkalemia);
a feeling of discomfort or burning in the pancreas (in patients with anacid gastritis or cholecystitis);
respiratory depression (due to hypermagnesemia);
feeling of heat (due to hypermagnesemia);
with rapid intravenous administration, symptoms of hyperkalemia and/or hypermagnesemia may develop.

When used simultaneously with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, ACE inhibitors, NSAIDs, the risk of developing hyperkalemia up to the appearance of arrhythmia and asystole increases. The use of potassium supplements together with glucocorticosteroids (GCS) eliminates the hypokalemia they cause. Under the influence of potassium, a decrease in the undesirable effects of cardiac glycosides is observed.

The drug enhances the negative dromo- and bathmotropic effects of antiarrhythmic drugs.

Due to the presence of potassium ions in the drug, when Panangin is used with ACE inhibitors, beta-blockers, cyclosporine, potassium-sparing diuretics, heparin, non-steroidal anti-inflammatory drugs (NSAIDs), the development of hyperkalemia is possible (monitoring the level of potassium in the blood plasma is necessary); with anticholinergic drugs - a more pronounced decrease in intestinal motility; with cardiac glycosides - a decrease in their effect.

Magnesium preparations reduce the effectiveness of neomycin, polymyxin B, tetracycline and streptomycin.

When Panangin is used simultaneously with potassium-sparing diuretics and ACE inhibitors, the risk of developing hyperkalemia increases (the level of potassium in plasma should be monitored).

Analogues of the drug Panangin

Structural analogues of the active substance:

Use during pregnancy and breastfeeding

There are no data on the negative effects of the drug in the form of a solution for intravenous administration during pregnancy and lactation (breastfeeding).

The drug should be used orally with caution during pregnancy (especially in the 1st trimester) and during lactation (breastfeeding).

Medicine Panangin - instructions and use

Available in the form of tablets and solution for intravenous administration. The active ingredients are potassium aspartate and magnesium aspartate.

Comparative composition of tablets and panangin injections

Panangin solution and tablets - instructions for use

The preferred method is slow drip administration. In this case, the sick person should be in a supine position. Thus, more complete absorption of minerals is achieved.

What are Panangin's indications for use?

Main indications for the use of panangin:

long-term maintenance and replacement therapy with cardiac glycosides;
arrhythmias of ventricular and atrial type;
weakness of the sinus node;
heart rate driver dissonance;
cardiovascular failure in acute and chronic form;
recovery period after myocardial infarction;
cardiac ischemia;
mineral deficiency.

Can Panangin be used during pregnancy and children?

The drug Panangin is prescribed to children in similar cases. In the newborn period, indications for use may be insufficiency of the cardiac pacemaker function and increased convulsive readiness.

Pregnancy, breastfeeding and childhood are not contraindications for treatment with this pharmacological agent.

What are the contraindications and side effects?

The following diseases and conditions may be contraindications for the use of solution and tablets:

individual intolerance to individual components;
dysfunction of the urinary system;
blockade of the heart muscle and pacemakers;
states of shock;
increased content of potassium and magnesium ions in the blood and plasma;
dehydration and severe intoxication.

Panangin - instructions for use

The instructions for use recommend using the drug Panangin not only in cases where a person has problems with the functioning of the heart muscle. This complex medicine helps to quickly and effectively restore the balance of potassium and magnesium in the chemical composition of the blood. Mandatory intake is prescribed by doctors during periods of active loss of these microelements. For example, when taking diuretics or during pregnancy, a Panangin tablet will help not only improve health, but also relieve possible negative consequences.

It is worth saying in more detail about the chemical composition of panangin. It contains magnesium aspartate and potassium aspartate. These substances are highly absorbable in the gastrointestinal tract. They are practically not destroyed by gastric juice and hydrochloric acid. 1 tablet of panangin contains about 160 mg of aspartate potassium available for absorption and approximately 140 mg of potassium.

The drug Panangin is available in two pharmacological forms: tablets with a protective film coating and an injection solution. It can only be administered intravenously. When administered intramuscularly, panangin injections cause severe tissue irritation.

1 ampoule of the prepared injection solution contains a little more than 450 mg of potassium and approximately 400 mg of magnesium. This amount constitutes the daily therapeutic dose necessary for adequate nutrition of the heart muscle.

When does the medicine Panangin find application?

Panangin is used in a variety of areas of modern medicine. It is worth noting that the microelements included in its composition have a powerful effect in relation to fermentation and acceleration of metabolic processes. In particular, scientists conducting research on this drug note that after its use, the need of muscle fibers for the consumed amount of oxygen is sharply reduced. Due to this factor, panangin has an anti-ischemic effect on the heart.

The second positive impact factor is the production of certain enzymes and essential amino acids under the influence of magnesium and potassium ions. The study reliably revealed that with the help of magnesium and potassium, more than 30 such substances are formed in the human body. And they all play an important role in metabolism and the formation of cellular structures.

It is important to understand that these two elements are connected by ionic chains. Therefore, it is impossible to adjust the level of potassium in human blood without additional administration of magnesium. The complex combination of these elements gives a lasting positive effect. Panangin also has the ability to bind excess potassium and magnesium. Everything should be in moderation. If a person has an increased level of potassium or magnesium in the blood, this leads to serious disturbances in the functioning of the kidneys, brain, and heart. Arrhythmias, shortness of breath, swelling of the face and legs, irritability, convulsions, and deterioration in general health may occur. In this case, panangin also comes to the rescue.

Do not forget about this drug during pregnancy. Regular use of panangin during pregnancy will help cope with many of the unpleasant consequences of this process. In particular, panangin during pregnancy helps eliminate swelling, toxicosis, and maintain normal functioning of the kidneys and heart muscle. It also has a positive effect on the formation of the brain and muscular system of the fetus.

The drug Panangin and indications for use

The medicine Panangin has different indications for use. Depending on the existing problem, it can be prescribed both to correct the electrolyte composition of the blood and to restore the muscle fibers of the heart muscle. In particular, the indications for the use of panangin are:

cardiac ischemia;
myocardial infarction;
cardiac arrhythmias of various origins;
in combination with cardiac glycosides;
when taking diuretics to replenish potassium and magnesium reserves;
during the recovery period after severe infectious diseases accompanied by large fluid losses;
after a blood transfusion;
in case of metabolic disorders;
with deficient nutrition, depleted of potassium and magnesium ions.

Indications for the use of Panangin in children are included in a special group. In early infancy, this drug is widely used to strengthen the heart muscle of the newborn. With some open heart defects, it helps to quickly close them. The use of panangin also has a beneficial effect on the relief of convulsive syndrome. If, when the body temperature rises or after crying, the baby experiences an increase in the threshold of convulsive activity, then we can say with confidence that he has a serious deficiency of potassium and magnesium ions. And this is a direct indication for the use of panangin.

Panangin solution - official instructions for use

Registration number: P N013093/01

Trade name: Panangin

International nonproprietary or generic name: Potassium aspartate + Magnesium aspartate &

Dosage form: concentrate for the preparation of solution for infusion.

Composition per ampoule:

Excipients: water for injection – up to 10 ml.

Description: Colorless or slightly greenish, transparent solution.

Pharmacotherapeutic group: potassium and magnesium preparation.

Pharmacological properties

Indications

Contraindications

Hypersensitivity to the drug, acute and chronic renal failure; Addison's disease; atrioventricular block II, III degree; cardiogenic shock (blood pressure Use caution

Pregnancy and lactation

There is no data on the harmful effects of the drug during pregnancy.

Directions for use and doses

For intravenous administration only.

The drug is suitable for combination therapy.

Side effect

Overdose

To date, cases of overdose have not been described. In case of overdose, the risk of symptoms of hyperkalemia and hypermagnesemia increases.

Symptoms of hyperkalemia: fatigue, myasthenia gravis, paresthesia, confusion, cardiac arrhythmia (bradycardia, atrioventricular block, arrhythmias, cardiac arrest).

Interaction with other drugs

Strengthens the negative dromo- and bathmotropic effect of antiarrhythmic drugs.

Eliminates hypokalemia caused by glucocorticoids.

Anesthetics enhance the inhibitory effect of magnesium on the central nervous system.

May enhance neuromuscular blockade caused by depolarizing muscle relaxants (atracurium besylate, decamethonium bromide, suxamethonium (chloride, bromide, iodide)).

Calcitriol increases the concentration of magnesium in the blood plasma, calcium preparations reduce the effect of magnesium.

Beta-blockers and non-steroidal anti-inflammatory drugs increase the risk of developing hyperkalemia up to the development of arrhythmia and asystole.

Pharmaceutically compatible with solutions of cardiac glycosides (improves their tolerability, reduces the undesirable effects of cardiac glycosides).

special instructions

With rapid administration, skin hyperemia may develop.

Particular caution should be exercised in the presence of diseases accompanied by hyperkalemia. In these cases, it is recommended to monitor the content of potassium ions in the blood.

The effect of the drug on the ability to drive vehicles and machinery

Release form

Concentrate for solution for infusion, 45.2 mg/ml +40 mg/ml.

10 ml of the drug in a colorless glass ampoule (hydrolytic class 1), 5 ampoules in a plastic tray. 1 plastic pallet in a cardboard box with instructions for medical use.

Storage conditions

Store at temperatures from 15 to 30 °C.

Keep out of the reach of children!

Best before date

Should not be used after the expiration date.

Vacation conditions

Manufacturer:

JSC "Gedeon Richter"

1103 Budapest, st. Dymroyi 19-21, Hungary

Consumer complaints should be sent to:

Moscow Representative Office of JSC Gedeon Richter

Moscow, 4th Dobryninsky lane, building 8.

PANANGIN

◊ Film-coated tablets white or almost white, round, biconvex, with a slightly shiny and uneven surface, almost odorless.

Excipients: colloidal silicon dioxide - 2 mg, povidone K30 - 3.3 mg, magnesium stearate - 4 mg, talc - 10 mg, corn starch - 86.1 mg, potato starch - 3.3 mg.

Shell composition: macrogol.4 mg, titanium dioxide (E171) - 5.3 mg, butyl methacrylate, dimethylaminoethyl methacrylate and methacrylate copolymer - 6 mg, talc - 7.3 mg.

50 pcs. - polypropylene bottles (1) - cardboard packs.

Solution for intravenous administration colorless or slightly greenish, transparent, without visible mechanical inclusions.

Excipients: water for injection - up to 10 ml.

10 ml - colorless glass ampoules (5) - plastic trays (1) - cardboard packs.

A drug that affects metabolic processes. Source of potassium and magnesium ions.

Potassium and magnesium are intracellular cations that play a major role in the functioning of many enzymes, in the formation of bonds between macromolecules and intracellular structures, and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, magnesium, calcium and sodium ions affects myocardial contractility. Endogenous aspartate acts as a conductor of ions: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cell. Potassium and magnesium aspartate improves myocardial metabolism. A lack of potassium and/or magnesium ions predisposes to the development of arterial hypertension, atherosclerosis of the coronary arteries and the occurrence of metabolic changes in the myocardium.

Magnesium is an important cofactor in more than 300 enzymatic reactions, including energy metabolism and the synthesis of proteins and nucleic acids. In addition, magnesium plays an important role in the functioning of the heart: it improves contractility and heart rate, leading to a decrease in myocardial oxygen demand. Decreased contractility of smooth muscle myocytes in the walls of arterioles, incl. coronary, leads to vasodilation and increased coronary blood flow. Magnesium has an anti-ischemic effect on myocardial tissue.

The combination of potassium and magnesium ions in one preparation is justified by the fact that potassium deficiency in the body is often accompanied by magnesium deficiency and requires simultaneous correction of the content of both ions in the body. With simultaneous correction of the levels of these electrolytes, an additive effect is observed (low levels of potassium and/or magnesium have a proarrhythmogenic effect), in addition, potassium and magnesium reduce the toxicity of cardiac glycosides without affecting their positive inotropic effect.

When taken orally, absorption of the drug is high.

Instructions for using panangin in ampoules: method of preparing a solution of the drug for injection

The drug Panangin is a source of magnesium and potassium ions - electrolytes that help maintain heart function. In addition, it has a pronounced effect on metabolic processes. The product is available in tablets and ampoules. In the register of medicines (RLS), the Latin name of the medicine is Pananginum.

Pharmacological features

Panangin ampoules contain vital substances for the body. With a lack of potassium and magnesium, a large number of ailments associated with cardiac activity can appear.

Potassium provides support for the membrane abilities of neurons, myocytes, and myocardial tissue particles. If the balance between intracellular calcium and its content outside the cells is disturbed, the number of contractions of the heart muscle increases, and tachycardia and attacks of arrhythmia subsequently appear.

Magnesium contained in the drug activates metabolic processes and ensures the integrity of various cells and structures of the body. This substance has a beneficial effect on the functioning of the heart muscle, relaxing the myocardium, relieving tension, reducing the heart rate and the main organ’s need for oxygen. Magnesium provides reliable protection of the myocardium from ischemia.

Taken together, potassium and magnesium contained in ampoules for Panangin injections reduce the toxicity of drugs - cardiac glycosides, without reducing their inotropic activity. If one of these elements is deficient, the following diseases may develop:

The solution for administering liquid panangin is colorless, in some cases its tint is slightly greenish. The composition of the drug is as follows:

Potassium aspartate;
Magnesium tetrahydrate;
Water as a supplement.

Panangin solution: instructions for use and indications

Panangin solution should be dripped in the following cases:

For complex treatment of cardiac function failure, acute stage of infarction, left ventricular arrhythmia or rhythm disturbances associated with overdose of glycoside substances;
For hypokalemia, if the potassium level in the blood is low;
In case of heart rhythm disturbances associated with poisoning with digitalis-based medications;
With atrial fibrillation;
To improve the tolerability of glycosides;
To replenish the lack of potassium and magnesium ions, if their amount in food is too low.

What does electrolyte deficiency lead to?

When the levels of magnesium and potassium in the body are low, this causes various ailments. Metabolic changes develop in the heart muscle, blood pressure rises, and plaques appear in the coronary arteries. Panangin makes it possible to replenish the missing amount of magnesium and potassium ions in the body. If the natural balance between these two elements is disrupted, the consequences may be as follows:

Myocardial contractility decreases;
The rhythm and frequency of the heartbeat changes;
The toxic effect of drugs for the treatment of CHF - cardiac glycosides - increases.

Heart rupture is considered the most important cause of complete loss of capacity of patients and their death. Taking into account statistics, in deceased patients the amount of magnesium in the body was half that of healthy people. This element is able to prevent the development of ischemic infarction and increase blood flow through the coronary arteries.

If there is a lack of potassium in the human body, arrhythmias that are dangerous to health may appear, the heart will not function fully, and the risk of stroke and heart attack will increase. So if you increase the amount of daily potassium consumed by 40 percent, you can reduce the likelihood of developing these pathologies.

Panangin in ampoules will help strengthen the heart, normalize metabolic functions, and improve myocardial activity. Instructions for use indicate that this drug effectively prevents premature diseases of the cardiovascular system, heart aging, and reduces the likelihood of developing atherosclerotic diseases, hypertension and heart rhythm disturbances. The cardiac impulse will be carried out unhindered, the walls of the blood vessels will strengthen, become wear-resistant and elastic.

The active elements of panangin stop the spread of atherosclerotic plaques and reduce excess blood viscosity, which prevents the formation of blood clots.

When is panangin needed?

Panangin is used for the following diseases and pathologies:

Heart attack;
Potassium and magnesium deficiency;
Functional heart failure;
Diarrhea;
Long-term vomiting or diarrhea accompanied by massive loss of electrolytes;
Paroxysmal tachycardia;
General poisoning;
Atrial fibrillation.

Attention! Panangin must be used when taking glucocorticosteroid medications, laxatives and diuretics.

This medicine is used for patent Botallic duct, patent foramen ovale and other minor cardiac anomalies in infants, strengthening the child's myocardium. It is also prescribed in pediatric and neurological practice to relieve seizures associated with a lack of potassium or magnesium ions.

Preparation and administration of the solution

The drug is prescribed for intravenous infusion. In this case, the medicine should be administered slowly. The duration of the solution during injection is 20 minutes. If necessary, repeated parenteral administration of panangin can be performed six hours after the first procedure, so that there are no side effects from an overdose. Much less commonly, this medicine is administered intramuscularly. The course of treatment consists of 10 procedures.

To prepare a medicine for a dropper, use one ampoule of the medicine, diluted with 5 percent glucose in a volume of up to 100 milliliters. You can also dilute the medicine in saline with the addition of riboxin.

Panangin can be used for complex therapy.

The use of the drug during lactation or pregnancy is permitted, only with great caution, since no studies have been conducted on the effects of panangin on the fetus.

If the patient has chronic kidney failure, anuria or oliguria, then the drug is not recommended.

Important information

It is necessary to pay special attention to the use of panangin in patients who have an increased risk of excess potassium in the body. In this case, you need to constantly monitor the content of potassium ions in the blood.

Regardless of the release form, a person should consult a cardiologist before using the medicine. If the drug is injected into a vein at a rapid pace, skin hyperemia may occur.

It should be noted that panangin does not affect the ability to drive a car, concentration or psychomotor function. The pharmaceutical analogue of panangin is the drug asparkam.

Panangin - instructions and price

ATX code: A12CX
Release form: tablets, solution

Introduction to instructions for use

1. Pharmacological action

2. indications for use

Heart rhythm disturbances caused by various reasons (ion balance disorders, poisoning with glycoside drugs);

3. Method of application

Panangin in the form of dragees:

In severe cases: the first 3 weeks of treatment - three doses per day, 3 tablets each, then the dose is reduced to 2-3 doses per day, 1 tablet each;

The duration of treatment is determined by the attending physician.

For intravenous jet infusions: 1 ml ampoule of saline or glucose solution;

4. Side effects

5. Contraindications

Functional kidney failure in acute and chronic forms;

6. During pregnancy and lactation

7. Interaction with other drugs

With the simultaneous use of Panangin with drugs that block the ACE enzyme or adrenaline receptors, Cyclosporine, Heparin, calcium-sparing diuretics, non-steroidal anti-inflammatory drugs, the risk of increasing the content of calcium ions in the blood increases;

8. Overdose

Increased content of calcium and magnesium ions in the blood (with intravenous administration of the drug);

9. Release form

Solution, 452 mg+400 mg/10 ml - amp. 5 pieces.

10. Storage conditions

11. Composition

In 1 tablet of Panangin:

potassium aspartate hemihydrate - 166.3 mg;

1 ml solution:

potassium aspartate (in the form of hemihydrate) - 42.5 mg;

12. Conditions for dispensing from pharmacies

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Description of the drug Panangin

Panangin is a drug used as part of a complex treatment of disorders of the cardiovascular system, as well as to replenish magnesium and potassium deficiency in the body.

Achieving the therapeutic effectiveness of the drug is ensured by the participation of active potassium and magnesium compounds in most processes that ensure the normal functioning of blood vessels and the heart:

maintaining the normal condition of the walls of blood vessels;
normalization of myocardial contractile function;
reducing blood viscosity and preventing thrombosis;
regulation of metabolic processes occurring in the heart muscle;
conduction of cardiac impulse;
slowing down the growth of atherosclerotic plaque, etc.

Instructions for use

Release form and composition

There are 2 dosage forms of Panangin:

magnesium aspartate tetrahydrate,

potassium aspartate hemihydrate

colloidal silicon dioxide;
potato and corn starch;
povidone;
talc;
magnesium stearate.

talc;
macrogol 6000;
titanium dioxide;
methacrylic acid copolymer.

Indications for use

Prescribing the drug is advisable as part of complex treatment:

heart failure;
acute myocardial infarction;
heart rhythm disturbances (mostly ventricular arrhythmias and arrhythmias provoked by an overdose of cardiac glycosides).

In addition, Panangin can be used during treatment with cardiac glycosides in order to improve their tolerability.

The use of Panangin tablets is also justified when there is a lack of magnesium and potassium in the body, caused by a decrease in their content in the diet.

Contraindications

Contraindications to the use of both dosage forms of Panangin are:

hyperkalemia;
Addison's disease;
renal failure (acute and chronic);
AV blockade I-III degree;
hypermagnesemia;
myasthenia gravis;
cardiogenic shock;
dehydration of the body;
excessive sensitivity to the components of the drug.

amino acid metabolism disorders;
acute metabolic acidosis;
hemolysis.

In addition to those listed above, the use of an injection solution has the following contraindications:

adrenal insufficiency;
age less than 18 years (due to the lack of data on the safety and effectiveness of the drug for persons belonging to this age category).

Panangin injection solution is prescribed with caution and after consulting a doctor for:

metabolic acidosis;
impaired renal function (if regular and systematic monitoring of magnesium contained in the blood serum is impossible);
urolithiasis, occurring against the background of metabolic disorders of magnesium, calcium, ammonium phosphate;
severe liver dysfunction;
risk of edema;
hypophosphatemia.

Directions for use and dosage

Panangin tablets. This dosage form of the drug must be taken orally after meals (in an acidic gastric environment, the effectiveness of Panangin may decrease).

As a rule, 1-2 tablets are prescribed 3 times a day, the maximum allowable daily amount of medication is 3 tablets 3 times a day.

The duration of treatment and repeated courses of therapy are determined by the doctor based on the characteristics of the body and the patient’s condition.

Injection. The injection solution is intended for intravenous administration; it is recommended to administer the drug by drip, in the form of a slow infusion, the optimal speed of which is 20 drops per minute. Repeated administration is possible after 4-6 hours.

The solution for injection is prepared as follows: 5% glucose (dextrose) solution, dissolve the contents of 1-2 ampoules of Panangin.

The drug can be used as part of combination therapy.

Interaction of Panangin and other drugs

The risk of developing hyperkalemia increases significantly with simultaneous therapy with Panangin and substances such as:

beta blockers;
potassium-sparing diuretics;
heparin;
non-steroidal anti-inflammatory drugs;
cyclosporine;
angiotensin-converting enzyme inhibitors.

Therapy with Panangin may reduce the effectiveness of:

An increase in the level of magnesium contained in the blood plasma can be caused by simultaneous use of the drug with calcitriol, and with simultaneous therapy with dexamethonium, atracurium, suxamethonium, stimulation of neuromuscular blockade is possible.

Absorption of Panangin may be reduced when the drug is used with drugs that have enveloping and astringent properties. In order to prevent this, it is necessary to maintain an interval of 3 hours between doses of drugs.

Video: “Foods that are most beneficial for the heart”

Side effects

The use of Panangin tablets in some patients may be accompanied by such undesirable manifestations as:

hypermagnesemia, hyperkalemia;
AV blockade, increased level of extrasystoles (paradoxical reaction);
diarrhea, nausea and vomiting, discomfort and a burning sensation in the stomach (usually observed among patients diagnosed with cholecystitis or anacid gastritis).

In some cases, rapid intravenous administration of Panangin solution can provoke symptoms of hypermagnesemia or hyperkalemia, and manifestations such as:

Use during pregnancy

Panangin can be used with caution and only after mandatory consultation with a doctor by pregnant and lactating women.