Novocaine injections (in ampoules): instructions for use. Novocain - description

In this article you can read the instructions for use of the drug Novocaine. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Novocaine in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Novocain, if available structural analogues. Use for anesthesia, blockades and dilution of drugs in adults, children, as well as during pregnancy and lactation.

Novocaine- local anesthetic with moderate anesthetic activity and wide range therapeutic action. Being a weak base, it blocks Na+ channels, preventing the generation of impulses in the endings of sensory nerves and the conduction of impulses along nerve fibers. Changes action potential in membranes nerve cells without a pronounced effect on the resting potential.

Suppresses the conduction of not only pain, but also impulses of other modalities. When absorbed and directly vascularly introduced into the bloodstream, it reduces the excitability of peripheral cholinergic systems, reduces the formation and release of acetylcholine from preganglionic endings (has some ganglion-blocking effect), eliminates spasm of smooth muscles, reduces the excitability of the myocardium and motor zones of the cerebral cortex.

Eliminates descending inhibitory influences reticular formation brain stem. Inhibits polysynaptic reflexes. In large doses, it can cause convulsions. It has a short anesthetic activity (the duration of infiltration anesthesia is 0.5-1 hour).

Pharmacokinetics

Subject to complete systemic absorption. The extent of absorption depends on the site and route of administration (especially vascularization and blood flow rate of administration) and the final dose (amount and concentration). It is quickly hydrolyzed by plasma and liver esterases to form two main pharmacologically active metabolites: diethylaminoethanol (has a moderate vasodilating effect) and para-aminobenzoic acid (is a competitive antagonist of sulfonamide drugs and can weaken them antimicrobial effect). It is excreted primarily by the kidneys in the form of metabolites; no more than 2% are excreted unchanged.

Indications

  • infiltration (including intraosseous) anesthesia;
  • for diluting medications and reducing the pain effect of administered medications;
  • vagosympathetic cervical, perinephric, circular and paravertebral blockades.

Release forms

Solution for injection (injections in ampoules) 0.25%, 0.5% and 2%.

Rectal suppositories 100 mg.

Instructions for use and dosage

Only for procaine solution (active ingredient of the drug Novocaine) 5 mg/ml (0.5%).

For infiltration anesthesia, 350-600 mg (70-120 ml) is administered. Higher doses for infiltration anesthesia for adults: the first single dose at the beginning of the operation - no more than 0.75 g (150 ml), then during each hour of the operation - no more than 2 g (400 ml) of solution.

With perinephric blockade (according to Vishnevsky), 50-80 ml are injected into the perinephric tissue.

For circular and paravertebral blockade, 5-10 ml is administered intradermally. For vagosympathetic blockade, 30-40 ml is administered.

To reduce absorption and prolong the action when local anesthesia, additionally inject a 0.1% solution of epinephrine hydrochloride - 1 drop per 2-5-10 ml of procaine solution.

Maximum dose for use in children over 12 years of age - 15 mg/kg.

Side effect

  • headache;
  • dizziness;
  • drowsiness;
  • weakness;
  • increase or decrease blood pressure;
  • peripheral vasodilation;
  • collapse;
  • bradycardia;
  • arrhythmias;
  • pain in chest;
  • itchy skin;
  • skin rash;
  • other anaphylactic reactions (including anaphylactic shock);
  • urticaria (on the skin and mucous membranes).

Contraindications

  • hypersensitivity (including to para-aminobenzoic acid and other local anesthetic esters);
  • for anesthesia using the creeping infiltrate method - pronounced fibrous changes in the tissues.

Use during pregnancy and breastfeeding

If it is necessary to prescribe the drug during pregnancy, the expected benefit to the mother should be compared with the potential risk to the fetus. With caution during childbirth.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

special instructions

Patients require monitoring of functions of cardio-vascular system, respiratory system and central nervous systems s.

Monoamine oxidase inhibitors should be discontinued 10 days before local anesthetic administration.

It should be borne in mind that when performing local anesthesia using the same total dose, the toxicity of procaine is higher, the more concentrated the solution is used.

Effect on ability to drive vehicles and mechanisms

During the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions.

Drug interactions

Strengthens the inhibitory effect on the central nervous system medicines For general anesthesia, sleeping pills, sedatives, narcotic analgesics and tranquilizers.

Anticoagulants (ardeparin sodium, dalteparin sodium, danaparoid sodium, enoxaparin sodium, heparin sodium, warfarin) increase the risk of bleeding. When treating the injection site with disinfectant solutions containing heavy metals, the risk of developing a local reaction in the form of pain and swelling increases.

Use with monoamine oxidase inhibitors (furazolidone, procarbazine, selegiline) increases the risk of developing a pronounced decrease in blood pressure. Strengthens and prolongs the effect of muscle relaxants. Vasoconstrictors (epinephrine, methoxamine, phenylephrine) prolong the local anesthetic effect.

Novocaine reduces the antimyasthenic effect of drugs, especially when used in high doses, which requires additional correction of the treatment of myasthenia gravis.

Cholinesterase inhibitors (antimyasthenic drugs, cyclophosphamide, demecaria bromide, ecothiopathy iodide, thiotepa) reduce the metabolism of local anesthetic drugs.

The metabolite of procaine (para-aminobenzoic acid) is an antagonist of sulfonamides.

Analogues of the drug Novocain

Structural analogues according to active substance:

  • Novocaine Bufus;
  • Novocain-Vial;
  • Novocaine base;
  • Novocaine solution for injection;
  • Procaine hydrochloride.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Dosage form:  injection Compound:

1 ml of solution contains:

active substance: procaine hydrochloride 5 mg;

Excipients : hydrochloric acid 0.1 M solution to pH 3.8-5, water for injection up to 1 ml.

Description:

Transparent colorless or slightly colored liquid.

Pharmacotherapeutic group:Local anesthetic ATX:  

N.01.B.A Aminobenzoic acid esters

N.01.B.A.02 Procaine

Pharmacodynamics:

A local anesthetic with moderate anesthetic activity and a wide range of therapeutic effects. Being a weak base, it blocks sodium channels, prevents the generation of impulses at the endings of sensory nerves and the conduction of impulses along nerve fibers. Changes the action potential in the membranes of nerve cells without a pronounced effect on the resting potential. Suppresses the conduction of not only pain, but also impulses of other modalities.

When absorbed, it reduces the excitability of peripheral cholinergic systems, reduces the formation and release of acetylcholine from preganglionic endings (has some ganglion-blocking effect), eliminates spasm of smooth muscles, reduces the excitability of the myocardium and motor areas of the cerebral cortex.

Eliminates descending inhibitory influences of the reticular formation of the brain stem. Inhibits polysynaptic reflexes. In large doses, it can cause convulsions. It has a short anesthetic activity (the duration of infiltration anesthesia is 0.5-1 hour).

Pharmacokinetics:

Are subject to complete systemic absorption. The extent of absorption depends on the site and route of administration (especially vascularity and blood flow velocity in the area of ​​administration) and the final dose (amount and concentration). It is rapidly hydrolyzed by plasma and liver esterases to form 2 main pharmacologically active metabolites: diethylaminoethanol (has a moderate vasodilator effect) and para-aminobenzoic acid (is a competitive antagonist of sulfonamide chemotherapeutic drugs and can weaken their antimicrobial effect). The half-life is 30-50 seconds, in the neonatal period - 54-114 s. It is excreted primarily by the kidneys in the form of metabolites; no more than 2% is excreted unchanged.

Indications:

Infiltration anesthesia;

Perinephric, circular and paravertebral blockades.

Contraindications:

Hypersensitivity (including to para-aminobenzoic acid and other local anesthetics);

Children under 12 years of age;

Pronounced fibrous changes in tissues (for anesthesia using the creeping infiltration method).

Carefully:

Emergency operations, accompanied acute blood loss;

Conditions accompanied by a decrease in hepatic blood flow (for example, with chronic heart failure, liver diseases), progression cardiovascular failure(usually due to the development of heart block and shock);

Inflammatory diseases or infection of the injection site;

Pseudocholinesterase deficiency;

Kidney failure;

Children's age (from 12 to 18 years);

In elderly patients (over 65 years old);

Weakened patients.

Pregnancy and lactation:

During pregnancy, the drug may be prescribed if it is well tolerated and if the potential benefit to the mother exceeds possible risk for the fetus.

During breastfeeding, the use of the drug is possible after a preliminary careful assessment of the expected benefits of therapy for the mother and the potential risk for the baby.

Directions for use and dosage:

Intramuscularly, intradermally, subcutaneously.

For infiltration anesthesia use a solution of Novocaine 5 mg/ml. Higher doses for adults: the first single dose at the beginning of the operation is no more than 150 ml of solution, then no more than 2.0 g of a 5 mg/ml solution is administered for each hour of the operation (that is, 400 ml of solution).

To reduce absorption and prolong the effect of local anesthesia, an additional 0.1% solution of epinephrine is administered - 1 drop per 2-5-10 ml of Novocaine solution. The maximum dose for injection without a vasoconstrictor is 500 mg. Higher single doses for intramuscular injection: 0.1 g (20 ml of 5 mg/ml solution).

For circular or paravertebral blockades Novocaine solution 5 mg/ml is administered intradermally.

With perinephric blockade (according to A.V. Vishnevsky) 50-80 ml of Novocaine solution 5 mg/ml is injected into the perinephric tissue.

With vagosympathetic cervical blockade 30-40 ml of Novocaine solution 5 mg/ml is injected into the perivascular tissue.

Doses for children depending on age and body weight have not been developed. The maximum dose for use in children over 12 years of age with all methods of anesthesia is 15 mg/kg.

Side effects:

From the central and peripheral nervous system: headache, dizziness, drowsiness, weakness, motor restlessness, loss of consciousness, convulsions, trismus, tremor, visual and hearing impairment, nystagmus, cauda equina syndrome (leg paralysis, paresthesia), paralysis respiratory muscles, motor and sensory block.

From the cardiovascular system: increased or decreased blood pressure, peripheral vasodilation, collapse, bradycardia, arrhythmias, chest pain.

From the urinary system:involuntary urination.

From the outside digestive system: nausea, vomiting, involuntary defecation.

From the blood side: methemoglobinemia.

Allergic reactions: itching of the skin, skin rash, other anaphylactic reactions (anaphylactic shock in the body), urticaria (on the skin and mucous membranes).

Others: return of pain, persistent anesthesia, hypothermia, impotence; during anesthesia in dentistry: insensitivity and paresthesia of the lips and tongue, prolongation of anesthesia. Overdose:

Symptoms: pallor skin and mucous membranes, dizziness, nausea, vomiting, “cold” sweat, increased breathing, tachycardia, decreased blood pressure, up to collapse, apnea, methemoglobinemia. The effect on the central nervous system (CNS) is manifested by a feeling of fear, hallucinations, convulsions, and motor agitation.

Treatment: maintaining adequate pulmonary ventilation, detoxification and symptomatic therapy.

Interaction:

Strengthens the inhibitory effect on the central nervous system of general anesthesia, sleeping pills and sedatives, narcotic analgesics and tranquilizers.

Anticoagulants (ardeparin sodium, danaparoid sodium, heparin) increase the risk of bleeding.

When treating the injection site of a local anesthetic with disinfectant solutions containing heavy metals, the risk of developing a local reaction in the form of pain and swelling increases.

Use with monoamine oxidase inhibitors (,) increases the risk of low blood pressure.

Strengthen and lengthen the effect of muscle relaxants.

At simultaneous use procaine together with narcotic analgesics has an additive effect, which is used during spinal and epidural anesthesia, while respiratory depression increases.

Vasoconstrictors (methoxamine) prolong the local anesthetic effect.

Procaine reduces the antimyasthenic effect of drugs, especially when used in high doses, which requires additional correction of the treatment of myasthenia gravis.

Cholinesterase inhibitors (antimyasthenic drugs, demecaria bromide, ecothiopathy iodide) reduce the metabolism of procaine.

The procaine metabolite (para-aminobenzoic acid) is a sulfonamide antagonist.

Special instructions:

Indication of the characteristics of the action of the drug when first taken or when discontinued

Patients require monitoring of the functions of the cardiovascular, respiratory and central nervous systems.

Monoamine oxidase inhibitors should be discontinued 10 days before local anesthetic administration.

Before use mandatory tests for individual sensitivity to the drug.

It must be taken into account that when performing local anesthesia using the same total dose, the toxicity of novocaine is higher, the more concentrated the solution is used.

It is not absorbed from mucous membranes and does not provide superficial anesthesia for cutaneous application.

Impact on the ability to drive vehicles. Wed and fur.:

During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Release form/dosage:Solution for injection, 5 mg/ml. Package:

5 ml per ampoule.

10 ampoules each with instructions for use and an ampoule knife or ampoule scarifier in a cardboard box.

Storage conditions:

Store in a place protected from light at a temperature not exceeding 30 °C.

Keep out of the reach of children.

Best before date:

Do not use after the expiration date stated on the packaging.

Conditions for dispensing from pharmacies: On prescription Registration number: P N000347/01 Registration date: 02.12.2011 / 22.09.2016 Expiration date: Indefinite Owner of the Registration Certificate: ORGANIKA, JSC
Russia Manufacturer:   Information update date:   24.06.2018 Illustrated instructions

Tradename: Novocaine

International nonproprietary name:

Procaine

Dosage form:

injection.

Compound:

1 ml of solution contains 5 mg or 20 mg of procaine hydrochloride as an active substance and excipients - 0.1 m hydrochloric acid solution, water for injection.
Description: clear, colorless or slightly colored liquid.

Pharmacotherapeutic group:

local anesthetic.
ATX code:[N01BA02]

Pharmacodynamics
A local anesthetic with moderate anesthetic activity and a wide range of therapeutic effects. Being a weak base, it blocks Na+ channels, preventing the generation of impulses in the endings of sensory nerves and the conduction of impulses along nerve fibers. Changes the action potential in the membranes of nerve cells without a pronounced effect on the resting potential. Suppresses the conduction of not only pain, but also impulses of other modalities. When absorbed and directly intravascularly administered, it reduces the excitability of peripheral cholinergic receptors, reduces the formation and release of acetylcholine from preganglionic endings (has some ganglion-blocking effect), eliminates spasm of smooth muscles, reduces the excitability of the myocardium and motor areas of the cerebral cortex. When administered intravenously, it has an analgesic, hypotensive and antiarrhythmic effect (increases the effective refractory period, reduces excitability, automaticity and conductivity); in large doses it can disrupt neuromuscular conduction. Eliminates descending inhibitory influences of the reticular formation of the brain stem. Inhibits polysynaptic reflexes. In large doses, it can cause convulsions. It has a short anesthetic activity (the duration of infiltration anesthesia is 0.5-1 hour).

Pharmacokinetics
Subject to complete systemic absorption. The degree of absorption depends on the site (degree of vascularization and blood flow velocity in the area of ​​administration), route of administration and total dosage. It is rapidly hydrolyzed by plasma and liver esterases with the formation of 2 main pharmacologically active metabolites: diethylaminoethanol (has a moderate vasodilator effect) and para-aminobenzoic acid (is a competitive antagonist of sulfonamide chemotherapy drugs and can weaken their antimicrobial effect). The half-life is 30-50 seconds, in neonotal period -54-114 s. It is excreted mainly by the kidneys in the form of metabolites, no more than 2% is excreted unchanged.

Indications for use

  • infiltration, conduction and epidural anesthesia;
  • vagosympathetic cervical, perinephric, circular and paravertebral blockades.

Contraindications
Hypersensitivity (including to para-aminobenzoic acid and other local anesthetics), childhood up to 12 years old.
For anesthesia using the creeping infiltrate method: pronounced fibrous changes in the tissues. For epidural anesthesia: atrioventricular block, marked decrease in blood pressure, shock, site infection lumbar puncture, septicemia.

Carefully
Emergency operations accompanied by acute blood loss; conditions accompanied by a decrease in hepatic blood flow (for example, with chronic heart failure, liver diseases); pseudocholinesterase deficiency; renal failure; children's age from 12 to 18 years and in elderly patients (over 65 years); weakened patients; pregnancy and childbirth.

Directions for use and doses
For infiltration anesthesia: use 0.25-0.5% solutions; for anesthesia according to the Vishnevsky method (tight creeping infiltration) - 0.125-0.25% solutions. To reduce absorption and prolong the effect of local anesthesia, an additional 0.1% solution of epinephrine hydrochloride is administered - 1 drop per 2-5-10 ml of procaine solution. Higher doses for infiltration anesthesia for adults: the first single dose at the beginning of the operation - no more than 500 ml for a 0.25% solution or 150 ml for a 0 5% solution. In the future, during each hour of surgery - no more than 1000 ml for a 0.25% solution or 400 ml for a 0.5% solution.
The maximum dose for use in children over 12 years of age is 15 mg/kg.
For conduction anesthesia: 1-2% solutions (up to 25 ml); for epidural - 2% solution (20-25 ml). For perinephric blockade (according to A.V. Vishnevsky), 50-80 ml of a 0.5% solution or 100-150 ml of a 0.25% solution are injected into the perirenal tissue, and for vagosympathetic blockade - 30-100 ml of a 0.25% solution.
For circular or paravertebral blockades, a 0.25% - 0.5% solution is injected intradermally.

Side effect
Headache, dizziness, drowsiness, weakness, cauda equina syndrome, convulsions, increased or decreased blood pressure, collapse, peripheral vasodilation, bradycardia, arrhythmia, chest pain, involuntary urination or defecation, impotence, methemoglobinemia, allergic reactions(up to anaphylactic shock).
From the digestive system: nausea, vomiting.
Other: return of pain, persistent anesthesia, hypothermia, during anesthesia in dentistry: numbness and paresthesia of the lips and tongue, prolongation of anesthesia.

Overdose
Symptoms: pallor of the skin and mucous membranes. Dizziness, nausea, vomiting, “cold” sweat, increased severity side effects. Treatment: maintaining adequate pulmonary ventilation, detoxification and sympathetic therapy.

Interaction
Strengthens the inhibitory effect on the central nervous system of general anesthesia, sleeping pills and sedatives, narcotic analgesics and tranquilizers.
When using local anesthetic drugs for spinal and epidural anesthesia with guanadrel, guanethidine, mecamylamine, trimetaphan, the risk of sharp decline blood pressure and bradycardia.
Anticoagulants (ardeparin, dalteparin, danaparoid, enoxaparin, heparin, warfarin) increase the risk of bleeding. When treating the injection site of a local anesthetic with disinfectant solutions containing heavy metals, the risk of developing a local reaction in the form of pain and swelling increases.
Use with MAO inhibitors (furazolidone, procarbazine, selegelin) increases the risk of developing hypotension.
Strengthen and lengthen the effect of muscle relaxants.
When prescribing procaine together with narcotic analgesics, you note an additive effect, which is used when performing spinal and epidural anesthesia, while respiratory depression increases.
Vasoconstrictors (epinephrine, methoxamine, phenylephrine) prolong the local anesthetic effect.
Procaine reduces the antimyasthenic effect of drugs, especially when used in high doses, which requires additional correction of the treatment of myasthenia gravis.
Cholinesterase inhibitors (antimyasthenic JIC, cyclophosphamide, demecarine, ecothiophate, thiotepa) reduce the metabolism of procaine.
The procaine metabolite (para-aminobenzoic acid) is a sulfonamide antagonist.

special instructions
Patients require monitoring of the functions of the cardiovascular, respiratory and central nervous systems. It is necessary to discontinue MAO inhibitors 10 days before the administration of a local anesthetic. During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions. Before use, testing for individual sensitivity to the drug is mandatory. It must be taken into account that when performing local anesthesia using the same total dose, the toxicity of novocaine is higher, the more concentrated the solution is used. Not absorbed from mucous membranes; does not provide superficial anesthesia for cutaneous use.

Release form:

injection solution 5 mg/ml, 20 mg/ml. 2.5ml-20mg/ml, 5.10ml - 5mg/ml in neutral glass ampoules. 10 ampoules along with instructions for use in a pack or cardboard box. 5 ampoules per blister pack. 2 ampoules per blister pack per cardboard pack. Each box contains an ampoule knife or a scarifier or a ceramic ampoule scarifier. When packaging ampoules with a break point or ring, an ampoule knife or scarifier is not inserted.

Storage conditions
List B. In a place protected from light.

Best before date
3 years. Do not use after the expiration date stated on the packaging.

Conditions for dispensing from pharmacies
Dispensed with a doctor's prescription.

Manufacturer/Organization receiving complaints:
FSUE "Armavir Biological Factory"
352212. Russia, Krasnodar region, Novokubansky district, Progress settlement, st. Mechnikova, 11

NOVOCAINE Novocaine

Active substance

›› Procaine*

Latin name

›› N01BA02 Procaine

Pharmacological group: Local anesthetics

Nosological classification (ICD-10)

›› I84 Hemorrhoids
›› K25 Stomach ulcer
›› K26 Ulcer duodenum
›› R11 Nausea and vomiting
›› Z100* CLASS XXII Surgical practice

Composition and release form

1 ml of solution for injection contains procaine hydrochloride 5 mg; in ampoules of 5 ml, in a cardboard box 10 pcs.

pharmachologic effect

pharmachologic effect- local anesthetic. Blocks the occurrence of an impulse and its conduction through nerve fiber- especially afferent.

Indications

Infiltration, conduction, epidural and spinal anesthesia; vagosympathetic and perinephric blockade; pain syndrome at peptic ulcer stomach and duodenum, hemorrhoids, nausea.

Contraindications

Hypersensitivity.

Side effects

Dizziness, weakness, hypotension, allergic reactions.

Directions for use and doses

IM - 5-10 ml of 1-2% solution 3 times a week for a month, after which a 10-day break is taken; For infiltration anesthesia, 0.25-0.5% solutions are used, for conduction anesthesia - 2% solution.
Inside - 1/2 teaspoon (for pain).

Best before date

Storage conditions

List B.: In a place protected from light, at a temperature not exceeding 30 °C.

* * *

NOVOCAINE (Novocainum). b-Diethylaminoethyl ester of para-aminobenzoic acid hydrochloride. Synonyms: Aethocain, Allocaine, Ambocain, Aminocaine, Anesthocaine, Atoxicain, Cerocain, Chemocain, Citocain, Ethocain, Genocaine, Herocaine, ISOCain, Jenacin, Maresaine Minocain, Naucain, Neocaine, Pancain, Paracaine, Planocaine, Polocainum, Procaine, Procaini Hydrochloridum , Procaine hydrochloride, Protocaine, Sevicaine, Syncaine, Syntocain, Topocaine, etc. Colorless crystals or odorless white crystalline powder. Very easily soluble in water (1:1), easily soluble in alcohol (1:8). Aqueous solutions sterilize at + 100 C for 30 minutes. Solutions of novocaine are easily hydrolyzed into alkaline environment. To stabilize, add O.1N. hydrochloric acid solution to pH 3.8 - 4.5. Novocaine was synthesized in 1905. Long time it was the main local anesthetic used in surgical practice. Compared to modern local anesthetics (lidocaine, bupivacaine, etc.), it has less strong anesthetic activity. However, due to the relatively low toxicity, large therapeutic breadth and additional valuable pharmacological properties, allowing it to be used in various areas medicine, he still has wide application. Unlike cocaine, novocaine does not cause addiction. In addition to the local anesthetic effect, novocaine, when absorbed and directly introduced into the bloodstream, has overall impact on the body: reduces the formation of acetylcholine and reduces the excitability of peripheral cholinoreactive systems, has a blocking effect on the autonomic ganglia, reduces spasms of smooth muscles, reduces the excitability of the heart muscle and motor areas of the cerebral cortex. In the body, novocaine is hydrolyzed relatively quickly, forming para-aminobenzoic acid and diethylaminoethanol. Novocaine breakdown products - pharmacologically active substances. para-Aminobenzoic acid (vitamin H 1) is integral part molecules folic acid; it is also included in a bound state in other compounds found in plant and animal tissues. For bacteria, para-aminobenzoic acid is a “growth factor”. By chemical structure it is similar to part of the sulfonamide molecule; entering into a competitive relationship with the latter, para-aminobenzoic acid weakens them antibacterial effect(cm. Sulfonamide drugs). Novocaine, as a derivative of para-aminobenzoic acid, also has an antisulfonamide effect. Diethylaminoethanol has moderate vasodilatory properties. Novocaine is widely used for local anesthesia - mainly for infiltration; It is of little use for superficial anesthesia, since it slowly penetrates through intact mucous membranes. Novocaine is also widely prescribed for therapeutic blockades. For infiltration anesthesin, 0.25 - 0.5% solutions are used; for anesthesia according to the A.V. method Vishnevsky (tight creeping infiltration) 0.125 - 0.25% solutions; for conduction anesthesia - 1 - 2% solutions; for epidural - 2% solution (20-25 ml). Sometimes novocaine is also prescribed for intraosseous anesthesia. For anesthesia of mucous membranes, novocaine is sometimes used in otorhinolaryngology. To obtain a superficial anesthetic effect, 10 - 20% solutions are required. With local anesthesia, the concentration of novocaine solutions and their quantity depend on the nature surgical intervention; method of administration, condition and age of the patient, etc. It should be borne in mind that with the same total dose of the drug, the more concentrated the solution used, the higher the toxicity. To reduce absorption and prolong the effect of novocaine solutions during local anesthesia, a solution of adrenaline hydrochloride (0.1%) is usually added to them - 1 drop per 2 - 5 - 10 ml of novocaine solution, since novocaine, unlike cocaine, does not cause vasoconstriction. Novocaine is also recommended for the treatment various diseases. Novocaine blockade aims to weaken reflex reactions that arise during development pathological processes. For perinephric blockade (according to A.V. Vishnevsky), 50 - 80 ml of a 0.5% solution or 1OO - 150 ml of a 0.25% solution of novocaine is injected into the perirenal tissue, and for vagosympathetic blockade - 30 - 100 ml of 0.25% solution. Novocaine solutions are also used intravenously and orally (for hypertension, late toxicosis of pregnant women with hypertensive syndrome, spasms blood vessels, phantom pain, gastric and duodenal ulcers, nonspecific ulcerative colitis, itching, neurodermatitis, eczema, keratitis, iridocyclitis, glaucoma, etc.). From 1 to 10 - 15 ml of a 0.25 - 0.5% solution is injected into a vein. Inject slowly, preferably isotonic solution sodium chloride. The number of injections (sometimes up to 10 - 20) depends on the severity of the disease and the effectiveness of treatment. To relieve spasms peripheral vessels and improving microcirculation during frostbite (in the pre-reactive period), a mixture consisting of 10 ml of 0.25% novocaine solution, 2 ml of 2% papaverine solution, 2 ml of 1% solution was proposed nicotinic acid and 10,000 units of heparin. Injected intra-arterially. Intravenous administration small amount novocaine potentiates the effect of drugs used for anesthesia, has an analgesic and anti-shock effect, and therefore it is sometimes used to prepare for anesthesia, during anesthesia (to enhance the effect of the main anesthetic) and in postoperative period(to relieve pain and spasms). Take 0.25 - 0.5% solution up to 30 - 50 ml orally 2 - 3 times a day. Intradermal injections of 0.25 - 0.5% solution are recommended for circular and paravertebral blockade for eczema, neurodermatitis, sciatica, etc. Suppositories (rectal) with novocaine are used as a local anesthetic and antispasmodic with spasms of intestinal smooth muscles. Novocaine (5 - 10% solution) is also used using the electrophoresis method. Due to the ability of the drug to reduce the excitability of the heart muscle, it is sometimes prescribed for atrial fibrillation- inject a 0.25% solution into a vein, 2 - 5 ml up to 4 - 5 times. More effective and specifically acting antiarrhythmic drugs are local anesthetics lidocaine and trimecaine and a novocaine derivative - novocainamide (see). Novocaine is used to dissolve penicillin in order to extend its duration of action (see Penicillin group drugs). Novocaine is also prescribed in the form intramuscular injections for some diseases that are more common in old age (endarteritis, atherosclerosis, hypertonic disease, spasms coronary vessels and cerebral vessels, diseases of the joints, rheumatic and infectious origin and etc.). Treatment is carried out in a hospital setting. A 2% solution of novocaine, 5 ml, is injected into the muscles 3 times a week; There are 12 injections per course, after which a 10-day break is taken. During the year, the course of treatment is repeated up to 4 times. The effect is observed mainly in early stages diseases associated with functional disorders CNS. Novocaine is usually well tolerated, but it can cause side effects and should be used with caution with all routes of administration. Some patients experience increased sensitivity to the drug (dizziness, general weakness, decreased blood pressure, collapse, shock). Allergic reactions may develop skin reactions(dermatitis, peeling, etc.). To identify hypersensitivity Novocaine is initially prescribed in reduced doses. First, 2 ml of a 2% solution is injected intramuscularly, after 3 days in the absence side effects- 3 ml of this solution and only then proceed to the administration of the full dose - 5 ml per injection. Higher doses of novocaine (for adults): single dose when taken orally 0.25 g, when administered into muscles (2% solution) - 0.1 g (5 ml), when administered into a vein (0 .25% solution) - 0.05 g (20 ml); daily intake 0.75 g; when administered into the muscles (2% solution) and into the vein (0.25% solution) - 0.1 g. For infiltration anesthesia, the following highest doses are established (for adults): the first single dose at the beginning operations - no more than 1.25 g of 0.25% solution (i.e. 500 ml) and 0.75 g of 0.5% solution (i.e. 150 ml). Subsequently, during each hour of surgery - no more than 2.5 g of 0.25% solution (i.e. 1000 ml) and 2 g of 0.5% solution (i.e. 400 ml). Release forms: powder; 0.25% and 0.5% solutions in ampoules of 1; 2; 5; 10 and 20 ml and 1% and 2% solutions, 1; 2; 5 and 10 ml; 0.25% and 0.5% sterile solutions of novocaine in bottles of 200 and 400 ml; 5% and 10% ointment; suppositories containing 0.1 g of novocaine. Novocain is included in the composition complex drug"Menovazin" (see). Storage: List B. In well-closed orange glass jars; ampoules and suppositories - in a place protected from light. Rp:. Sol. Novocaini 0.25% 200 ml D.S. For infiltration anesthesia Rp.: Sol. Novocaini 1% 10 ml D.t.d. N. 5 in ampull. S. For conduction anesthesia Rp.: Novocaini 1.25 Natrii chloridi 3.0 Kalii chloridi 0.038 Calcii chloridi 0.062 Aq. pro injection. 500 ml M. Steril.! D.S. For anesthesia according to the method of A.V. Vishnevsky Rp.: Novocaini 0.5 Aq. destill. 200 ml M.D.S. Inside, 1 tablespoon Rp.: Sol. Novocaini 2% 5 ml D.t.d. N. 6 in ampull. S. 5 ml into muscles 1 time every 2 days

Dictionary of medicines. 2005 .

Synonyms:

Ozhegov's explanatory dictionary Wikipedia

novocaine- NOVOCAINE, a, m Medicine is a synthetic substitute for cocaine; used for local anesthesia and treatment. Before the operation, the patient was administered novocaine... Explanatory dictionary of Russian nouns

Medicine from the group of painkillers; para-aminobenzoic acid diethylaminoethyl ester hydrochloride. N.'s solutions are used for local anesthesia (See Anesthesia), novocaine blockade (See Novocaine blockade), and... ... Great Soviet Encyclopedia

M. A drug used as an anesthetic. Ephraim's explanatory dictionary. T. F. Efremova. 2000... Modern Dictionary Russian language Efremova

Novocaine is used in medical practice several decades. The use of novocaine marked the beginning of a new era of pain relief. The drug is in demand and widely used in medicine.

What is novocaine?

The discovery of novocaine is not accidental, but a natural result of an intensive search. In 1905, the German scientist Alfred Einhorn, as a result of many years of research, synthesized procoline compounds. Procoline hydrochloride has been produced since 1906. The trade name of the drug is novocaine, otherwise “new cocaine”. The drug was undoubtedly inferior to the well-known cocaine in terms of the degree of analgesic effect, but the use of novocaine made it possible to refrain from using a substance that leads to drug addiction.

Forms of release of the drug novocaine

  1. Ointment;
  2. Suppositories for rectal administration;
  3. Solution.

Ointment necessary for eczema, dermatosis, combined with itching and scratching. Apply twice a day. The skin is lubricated thinly and does not rub in.

Candles reduces well painful sensations for cracks and anus. After cleansing the intestines. Administer twice during the day.

Novocaine solutionfamous drug local anesthesia. Produces an analgesic effect, reduces stimulation of the brain, head and heart muscle. Intravenous administration reduces spasms of smooth muscles. Medicinal solution used in the form of injections and orally, for the treatment of toxicosis of pregnant women. How antishock agent the use of novocaine is recommended for frostbite and skin. Blockades with this drug reduce the reflex reactions that appear when pathological changes. Subcutaneous administration is prescribed for patients with eczema and sciatica. Indispensable for dissolving antibiotics to enhance and last the effect of injections. It acts 30 minutes after the drug enters the blood. The use of novocaine is appropriate for many types of anesthesia.

Novocaine blockade is carried out with a properly prepared solution. Bring a certain amount of distilled water to a boil and cool. Add novocaine powder. Instead of water, you can use saline solution. The solution should be of low concentration up to 0.5%. Use freshly prepared at a temperature of 37-38 degrees. Old and cold solutions should not be used, since healing effect will not be achieved.

Small doses of the drug without risk to the development of the fetus are administered to pregnant women with toxicosis. Dental treatment is generally not complete without the use of novocaine. Local anesthesia An injection into the gum will not harm the child’s health. Increased blood pressure during pregnancy is unacceptable. Novocaine can cope with problems. The medicine will smoothly lower blood pressure parameters and provide moderate load on the heart, relaxes the muscles. Pay careful attention to the dosage. Women are allowed to use it in small doses. Hemorrhoids, which often occur during pregnancy, cause a lot of suffering. Novocaine ointment and suppositories can relieve pain. Safe use allowed at any stage of pregnancy. In case of possible injections with novocaine in complex treatment. It is important to follow the dosage. Large doses can cause vomiting and arrhythmia.

Can Novocaine be used for children?

The drug is contraindicated for children under 12 years of age. From 12-18 years of age, the use of novocaine should be done with great caution. As a dilution of antibiotics for injection.

Novocaine for heel spurs

In getting rid of this disease, a method using an anesthetic has proven effective. Its essence lies in pinching the heel in the area heel spurs novocaine solution. A 0.5% concentration of the drug is used. Novocaine blockade is done in acute period twice a day.

Storage of novocaine - expiration date

I would like to emphasize that the drug should be stored at low temperatures without access to light. At proper storage The shelf life will be three years. Use in consultation with your doctor.