Lazolvan syrup for children: instructions for use and the best analogues of the medicine. Average price in Russia. ACC or Lazolvan - which is better

Registration number: P N014992/03-160713
Tradename: Lazolvan®
International generic name: ambroxol
Dosage form: syrup

Compound
5 ml of syrup contains:
active substance- ambroxol hydrochloride 15 mg;
Excipients- hyaetellose (hydroxyethylcellulose) 10 mg, sorbitol solution 70% 2.5 g, glycerol 85% (glycerol 85%) 750 mg, benzoic acid 10 mg, propylene glycol 150 mg, raspberry flavor D9599 17.5 mg, tartaric acid 5 mg , purified water 2.2925 g.

Description
Syrup is a transparent or almost transparent, colorless or almost colorless, slightly viscous liquid with a fruity, aromatic odor.

Pharmacotherapeutic group
Expectorant, mucolytic agent

ATX code: R05CB06

pharmachologic effect

Studies have shown that ambroxol, the active ingredient of Lazolvan®, increases secretion in the respiratory tract. It enhances the production of pulmonary surfactant and stimulates ciliary activity. These effects lead to increased mucus flow and transport (mucociliary clearance). Increasing mucociliary clearance improves sputum discharge and relieves cough. In patients with chronic obstructive pulmonary disease, long-term therapy with Lazolvan® (for at least 2 months) led to a significant reduction in the number of exacerbations. There was a significant decrease in the duration of exacerbations and the number of days of antibiotic therapy.

Pharmacokinetics

For all dosage forms ambroxol immediate release characterized by rapid and almost complete absorption with a linear dose dependence in the therapeutic concentration range. Maximum plasma levels after oral administration are achieved within 1 - 2.5 hours. The distribution volume is 552 l. In the therapeutic concentration range, binding to plasma proteins is approximately 90%. The transition of ambroxol from blood to tissues during oral administration happens quickly. The highest concentrations of the active component of the drug are observed in the lungs.
Approximately 30% of the administered oral dose undergoes first pass through the liver. Studies on human liver microsomes have shown that CYP3A4 is the predominant isoform responsible for the metabolism of ambroxol to dibromoantranilic acid. The remainder of ambroxol is metabolized in the liver, mainly by glucuronidation and by partial breakdown to dibromoantranilic acid (approximately 10% of the administered dose), and also not large quantity additional metabolites. The terminal half-life of ambroxol is 10 hours. The total clearance is within 660 ml/min, at renal clearance accounts for approximately 83% of total clearance.
No clinically significant effect of age and gender on the pharmacokinetics of ambroxol was found, so there is no basis for selecting the dosage based on these characteristics.

Indications for use

Spicy and chronic diseases respiratory tract with the release of viscous sputum: acute and Chronical bronchitis, pneumonia, chronic obstructive pulmonary disease, bronchial asthma with difficulty in sputum discharge, bronchiectasis.

Contraindications

Hypersensitivity to ambroxol or other components of the drug, pregnancy (first trimester), lactation period.
Lazolvan® syrup (15 mg/5 ml) contains 10.5 g of sorbitol based on the maximum recommended daily dose (30 ml). Patients with rare hereditary intolerance people with fructose should not take this drug.

Carefully use Lazolvan® during pregnancy (II - III trimester), with renal and/or liver failure.

Use during pregnancy and breastfeeding

Ambroxol penetrates the placental barrier. Preclinical studies have not revealed direct or indirect adverse effects on pregnancy, embryonic/fetal,
postnatal development and childbirth.
Extensive clinical experience There was no evidence of ambroxol use after 28 weeks of pregnancy negative influence drug for the fetus.
However, normal precautions must be taken when using the medicine during pregnancy. It is especially not recommended to take Lazolvan® in the first trimester of pregnancy.
Ambroxol can be excreted in human milk. Although unwanted effects were not observed in breast-fed children; it is not recommended to use Lazolvan® syrup during lactation.
Prior clinical studies of ambroxol have not shown any negative effects on fertility.

Directions for use and doses

Inside.
The drug is prescribed to adults and children over 12 years of age: 10 ml 3 times a day;
children from 6 to 12 years old: 5 ml 2-3 times a day;
children from 2 to 6 years old: 2.5 ml 3 times a day;
children under 2 years old: 2.5 ml 2 times a day.
Lazolvan® in syrup can be taken regardless of meals.
If symptoms of the disease persist within 4-5 days from the start of treatment, it is recommended to consult a doctor.

Side effect

Violations by gastrointestinal tract
Often (1.0 - 10.0%) - nausea, decreased sensitivity in the oral cavity or pharynx;
Uncommon (0.1 - 1.0%) - dyspepsia, vomiting, diarrhea, abdominal pain, dry mouth;
Rarely (0.01 - 0.1%) - dry throat.
Disorders immune system, damage to the skin and subcutaneous tissues
Rarely (0.01 - 0.1%) - rash, urticaria; anaphylactic reactions (including anaphylactic shock)*, angioedema*, itching*, hypersensitivity*.
Disorders from the outside nervous system
Often (1.0 - 10.0%) - dysgeusia (impaired sense of taste).

* - these adverse reactions were observed with widespread use drug; with 95% probability data frequency adverse reactions- infrequently (0.1%-1.0%), but possibly lower; the exact frequency is difficult to estimate since they were not noted during clinical studies involving 1528 patients.

Overdose

Specific symptoms of overdose in humans have not been described.
There are reports of accidental overdose and/or medical error, as a result of which symptoms of known side effects of Lazolvan® were observed: nausea, dyspepsia, diarrhea, vomiting, abdominal pain. In this case, there may be a need for symptomatic therapy.
Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug, symptomatic therapy.

Interaction with other drugs

No clinically significant, undesirable interactions with other drugs have been reported. Increases the penetration of amoxicillin, cefuroxime, and erythromycin into the bronchial secretions.

special instructions

It should not be combined with antitussives that make it difficult to remove sputum. The sorbitol contained in the syrup may have a mild laxative effect.
In patients with severe skin lesions - Stevens-Johnson syndrome or toxic epidermal necrolysis - fever, body pain, rhinitis, cough and sore throat may appear in the early phase. During symptomatic treatment, it is possible to erroneously prescribe mucolytic agents such as ambroxol hydrochloride. There are isolated reports of the detection of Stevens-Johnson syndrome and toxic epidermal necrolysis, which coincided with the administration of the drug; however, there is no causal relationship with the drug.
If the above syndromes develop, it is recommended to stop treatment and immediately seek medical help.
If renal function is impaired, Lazolvan® should be used only on the recommendation of a doctor.

The effect of the drug on the ability to drive vehicles and machinery

There were no cases of the drug affecting the ability to drive vehicles and mechanisms. Studies on the effect of the drug on the ability to drive vehicles and engage in other potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions were not carried out.

Release form
Syrup 15 mg/5ml.
100 ml in amber or brown glass bottles with a screw cap made of polyethylene or aluminum with tamper evident. The bottle is placed in a cardboard box along with instructions for use and a measuring cup.

In this article you can find instructions for use medicinal product Lazolvan. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Lazolvan in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogs of Lazolvan if available structural analogues. Use for the treatment of bronchitis, pneumonia and cough in adults, children, as well as during pregnancy and lactation.

Lazolvan- mucolytic drug.

Studies have shown that ambroxol ( active substance drug Lazolvan) increases secretion in the respiratory tract. Enhances the production of pulmonary surfactant and stimulates ciliary activity. These effects lead to increased mucus flow and transport (mucociliary clearance). Increasing mucociliary clearance improves sputum discharge and relieves cough.

Pharmacokinetics

Lazolvan is characterized by rapid and almost complete absorption with a linear dose dependence in the therapeutic concentration range. The transition of ambroxol from the blood to tissues when administered orally occurs quickly. The highest concentrations of the active component of the drug are observed in the lungs. Approximately 30% dose taken undergoes a “first pass” effect through the liver. The remainder of ambroxol is metabolized in the liver, mainly by conjugation.

Indications

Acute and chronic diseases of the respiratory tract, accompanied by the release of viscous sputum:

• acute and chronic bronchitis;
• pneumonia;
• chronic obstructive pulmonary disease;
• bronchial asthma with difficulty in sputum discharge;
• bronchiectasis.

Release forms

Tablets 30 mg.

Syrup (children's form of the drug).

Solution for oral administration and inhalation.

Lozenges 15 mg.

Instructions for use and dosage

The drug in tablet form is prescribed to adults 30 mg 3 times a day.

If necessary, to enhance the therapeutic effect, you can prescribe 60 mg 2 times a day. The tablets are taken after meals with liquid.

The drug in the form of a syrup of 15 mg/5 ml is prescribed to adults and children over 12 years of age, 10 ml (2 teaspoons) 3 times a day; children aged 6 to 12 years - 5 ml (1 teaspoon) 2-3 times a day; children aged 2 to 6 years are prescribed 2.5 ml (1/2 teaspoon) 3 times a day; children under 2 years old - 2.5 ml (1/2 teaspoon) 2 times a day.

The drug in the form of a syrup 30 mg/5 ml is prescribed to adults and children over 12 years of age 5 ml (1 teaspoon) 3 times a day; children aged 6 to 12 years - 2.5 ml (1/2 teaspoon) 2-3 times a day.

Taking the drug for more than 4-5 days is possible only under the supervision of a doctor.

Lazolvan in the form of syrup should be taken during meals with liquid.

Lazolvan in the form of an inhalation solution can be used with any modern inhalation device, except for evaporating inhalers. The drug is mixed with saline solution in a 1:1 ratio to achieve optimal air humidification in the respirator.

During inhalation, in order to avoid cough reflex caused by take a deep breath, the patient should breathe calmly. It is recommended to warm the inhaled solution to body temperature. Patients with bronchial asthma are recommended to take inhalations after taking bronchodilators.

Side effect

• heartburn;
• dyspepsia;
• nausea, vomiting;
• diarrhea;
• skin rash;
• hives;
• angioedema;
• anaphylactic reactions (including anaphylactic shock).

Contraindications

• 1st trimester of pregnancy;
• hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

Lazolvan penetrates the placental barrier.

IN experimental studies in animals, no direct or indirect adverse effects on pregnancy, embryonic, prenatal and postnatal development and childbirth were detected.

Clinical studies during 28 weeks of pregnancy found no evidence of a negative effect of the drug on the fetus.

However, the usual precautions should be taken when using the drug during pregnancy. It is especially not recommended to take Lazolvan in the 1st trimester of pregnancy.

Ambroxol can be excreted in human milk. Therefore, it is not recommended to prescribe Lazolvan to nursing mothers. However, an adverse effect in newborns is unlikely.

special instructions

Should not be used in combination with antitussives that impede the removal of sputum.

Lazolvan syrup (15 mg/5 ml) contains 10.5 g of sorbitol based on the maximum recommended daily dose (30 ml). Patients with rare hereditary fructose intolerance should not take this drug. It may also have a mild laxative effect.

Lazolvan syrup (30 mg/5 ml) contains 5 g of sorbitol based on the maximum recommended daily dose (20 ml). Patients with rare hereditary fructose intolerance should not take this drug.

Lazolvan tablets (30 mg) contain 684 mg of lactose based on the maximum recommended daily dose (120 mg). Patients with rare hereditary galactose intolerance, Lapp lactase deficiency or impaired glucose/galactose absorption should not take this drug.

Very rare cases of severe skin lesions, for example, Stevens-Johnson syndrome and Lyell's syndrome; however, the relationship with the drug has not been proven. If the above syndromes develop, it is recommended to stop treatment and immediately seek medical help.

Drug interactions

Simultaneous use with antitussive drugs leads to difficulty in sputum discharge while reducing cough.

Ambroxol increases the penetration of amoxicillin, cefuroxime, erythromycin, and doxycycline into the bronchial secretions.

Lazolvan is compatible with drugs that inhibit labor.

Analogues of the drug Lazolvan

Structural analogues of the active substance:

• Ambrobene;
• AmbroHEXAL;
• Ambroxol;
• Ambroxol Vramed;
• Ambroxol retard;
• Ambroxol-Verte;
• Ambroxol-Vial;
• Ambroxol-Richter;
• Ambroxol-Teva;
• Ambroxol-Hemofarm;
• Ambrolan;
• Ambrosan;
• Ambrosol;
• Bronchoxol;
• Bronchorus;
• Deflegmin;
• Bronchovern drops;
• Lazolangin;
• Medox;
• Mucobron;
• Neo-Bronchol;
• Remebrox;
• Suprima-coff;
• Fervex for cough;
• Flavamed;
• Halixol.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

One of the most common reasons A visit to the pediatrician is the presence of a cough in a child. It accompanies most respiratory diseases of a viral and bacterial nature. In each specific case, the doctor and parents are faced with the question of choice safe medicine, which can reduce the severity of cough and alleviate the child’s condition. Moreover, the drug must not only effectively cope with unpleasant symptom, it should be convenient to give to babies. As the instructions for use of Lazolvan describe, syrup for children is just such a remedy.

Normally, the natural mechanism for cleansing the respiratory tract is ensured by the coordinated movement of the cilia of the respiratory epithelium (because of this property it is also called ciliated). The waves of these movements are directed from bottom to top, which allows you to get rid of mucus, bacteria and foreign particles that get inside along with the inhaled air.

But with inflammation in the trachea and bronchi, a number of changes occur, leading to increased secretion of sputum, spasm of the bronchioles and disruption of the mechanism of natural cleansing of the tracheobronchial tree. To clear the airways of pathological contaminants, a cough occurs - protective reflex, aimed at removing accumulated sputum.

Therapeutic effects

The action of the active substance of the drug "Lazolvan" - ambroxol - is aimed at restoring the drainage function of the tracheobronchial tree and improving sputum discharge. It has the following effects:

• mucolytic (sputum thinning);
• expectorant.
• anti-inflammatory.

They are ensured by the influence of the drug on the properties of sputum - a decrease in its viscosity due to the breakdown of the long chains of molecules of which it consists. In addition, ambroxol is able to stimulate the production of bronchial secretions and change it chemical composition. All this helps to thin the mucus and promote its better movement through the respiratory tract.

Very important feature Ambroxol is the ability to stimulate the work of epithelial cilia. This speeds up the removal of mucus and clears the airways. These properties of ambroxol are especially useful in the presence of spasm of bronchioles (bronchial obstruction).

Another important effect of ambroxol is the ability to enhance the penetration of a number of antibiotics (macrolides, penicillins, cephalosporins) into structures respiratory system. Experiments have proven that this drug increases concentration antibacterial agents in the alveoli and bronchial secretions.

Pharmaceutical forms

Big advantage this tool in front of others similar drugs is the variety of its release forms intended specifically for children:

• pills;
• solution for inhalation;
• lozenges;
• syrup.

In pediatrics, Lazolvan syrup is most often used. It is available in 100 and 200 ml bottles and may contain varying amounts of the active ingredient. 5 ml can contain 15 or 30 mg of ambroxol hydrochloride. This point must be taken into account when calculating daily dosage Lazolvan products for children.

Some parents are interested in the question of whether Lazolvan can be given to children under one year of age. Yes, you can. "Lazolvan" syrup with a dosage of 15 mg is used to treat children even one month old. The drug containing ambroxol hydrochloride 30 mg is recommended only for patients over six years of age.

Indications

Indications for the use of Lazolvan are diseases respiratory system, especially with an accompanying dry cough. “Lazolvan” cough syrup is recommended for children in the following cases:

• pneumonia;
• tracheitis, laryngitis;
• acute and chronic bronchitis;
• asthmatic conditions;
• pulmonary edema not associated with heart pathology;
• bronchiectasis (saccular dilatations of the bronchi);
• cystic fibrosis (bronchiectasis and pathologically thick secretion).

Given pharmacological agent They are also used to prevent pulmonary edema.

Instructions for the use of Lazolvan syrup for the treatment of children

The product has a sweetish taste and berry aroma, so most young children drink it with pleasure. Along with the bottle, a special dispensing spoon for dosing the medicine is included in the package. As a rule, the regimen for taking the drug is determined by the attending physician. Recommended doses are presented in the tables.

Table - Dosages of the drug containing 15 mg of active substance in 5 ml of syrup

Table - Dosages of a medicine containing 30 mg of active substance in 5 ml of syrup

The medicine can be given to children after or before meals; the intake and amount of food does not affect the rate of its absorption active ingredients. On average, the course of treatment with Lazolvan for children is seven to ten days. How much and how to give Lazolvan to a child can be further clarified by a pediatrician.

The exact dosage and duration of taking the drug with ambroxol is determined by the attending physician. It is not recommended to treat a child’s cough on your own; it is better to entrust this issue to a pediatrician.

How to enhance the effect of a medicine

To increase the effectiveness of ambroxol, additional conditions must be met:

• drinking plenty of water;
• sufficient air humidity;
• performing breathing exercises.

These measures reduce the viscosity of sputum and increase its discharge.

It is best to give a child a mixture with ambroxol in daytime days, until 18.00-19.00 pm. The child’s daily activity promotes better drainage of the tracheobronchial tree and prevents its “clogging.”

Inhalations with ambroxol

Enough effective technique to combat cough is the use of the inhalation form of Lazolvan. In this case, a special device is used - a nebulizer. The bottle with the solution has a special drop dispenser for accurate calculation of the amount of medicine. Before diluting Lazolvan for inhalation for a child, you should accurately determine the required amount of the drug. The dosages of the medicine for preparing the inhalation solution are given in the table.

Table - Doses of solution for inhalation

Using a nebulizer

1. Measure out required amount drops of the drug into a small container.
2. Add the same volume of saline solution (sold at the pharmacy) and mix.
3. Warm the resulting mixture to body temperature.
4. Pour the solution into the inhaler container.
5. Turn on the nebulizer and carry out the procedure.

During the procedure, the child should breathe calmly; there is no need to perform forced breathing. breathing movements. The duration of inhalation with Lazolvan for children is no more than five to ten minutes.

Taking the solution orally

Lazolvan solution can also be used internally. Considering that this medicine does not contain sweeteners or flavorings, it is indicated for children prone to allergic reactions. Since the solution does not have much pleasant taste, it is recommended to add it to water, milk or tea in the doses indicated in the table.

Table - Required dosages of the solution when taken orally

When is it contraindicated?

There are not many contraindications to the use of Lazolvan. It is not prescribed to children in the following situations:

• if you are allergic to its ingredients;
• if there is a problem with the kidneys or liver.

Since Lazolvan contains sorbitol, the medicine is not recommended for patients with congenital intolerance fructose. In addition, sorbitol can have a slight laxative effect, so patients taking it as part of other products should take this point into account.

"Lazolvan" syrup is not prescribed together with drugs that block the cough reflex. This may worsen sputum production during wet cough and cause additional blockage of the bronchi.

Portability

According to doctors and parents, children tolerate Lazolvan syrup very well. It rarely causes the following side effects:

• disruption of the gastrointestinal tract (nausea, dry mouth, abdominal pain, loose stools);
• allergic manifestations in the form skin rashes, angioedema;
• change in taste sensations.

If a child accidentally drinks much more of the drug than he should, he may develop symptoms of an overdose. They are expressed by the same gastrointestinal symptoms as when side effects occur: nausea, vomiting, abdominal discomfort. In this case, gastric lavage and taking adsorbents are indicated.

Where can I buy

"Lazolvan" belongs to the over-the-counter group of drugs. Therefore, it can be purchased at a pharmacy even without a prescription. The cost of one 100 ml bottle of syrup ranges from 210 to 290 rubles (as of July 2017), depending on the dosage and trade markup.

In addition, in the pharmacy chain you can find analogues of the original drug:

• "Halixol";
• "Ambrohexal";
• "Vicks-active AmbroMed".

These products also contain ambroxol. There is also a spray "Lazolvan rino" for children. However, it has nothing to do with ambroxol and is vasoconstrictor, designed to eliminate swelling of the nasal mucosa and fight the runny nose.

Thus, to treat cough even in the youngest children, you can safely use “Lazolvan” - children’s syrup has a minimum of contraindications and rarely causes side effects. It can be combined with other drugs, and the effectiveness of the drug has been proven by more than 30 years of practice in its use in pediatrics.

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Self-medication can be harmful to your health.
You should consult your doctor and read the instructions before use.

Lazolvan syrup: instructions for use

Compound

Syrup 15 mg/5 ml: 5 ml of syrup contains the active substance - ambroxol hydrochloride 15 mg; excipients - benzoic acid (E210), hydroxyethylcellulose, acesulfame potassium (E950), liquid sorbitol, non-crystallizing (E420), glycerin 85% (E422), “Wild berries” flavoring РНL132195, “Vanilla” flavoring 201629, purified water.

Syrup 30 mg/5 ml: 5 ml of syrup contains the active substance - ambroxol hydrochloride 30 mg; excipients - benzoic acid (E210), hydroxyethylcellulose, acesulfame potassium (E950), liquid sorbitol, non-crystallizing, (E420), glycerin 85% (E422), “Strawberry and cream” flavoring РНL132200, “Vanilla” flavoring 201629, purified water .

Description

Transparent or almost transparent, colorless or almost colorless, slightly viscous syrup.

Medicines used for coughs and colds. Mucolytic agents.

ATX code: P05SV06.

pharmachologic effect

Has secretomotor, secretolytic and expectorant effects; stimulates the serous cells of the glands of the bronchial mucosa, increases the content of mucous secretion and the release of surfactant in the alveoli and bronchi; normalizes the disturbed ratio of serous and mucous components of sputum. By activating hydrolyzing enzymes and enhancing the release of lysosomes from Clara cells, it reduces the viscosity of sputum. Increases motor activity cilia of the ciliated epithelium, increases mucociliary transport of sputum.

In an in vitro study, a local anesthetic effect was observed, which is explained by the property of ambroxol to block sodium channels. This process is reversible and depends on concentration. Clinically, when inhaled, ambroxol leads to quick withdrawal pain and associated discomfort in the upper respiratory tract.

An in vitro study also found that the release of cytokines from tissue mononuclear and polymorphonuclear blood cells was significantly reduced.

Pharmacokinetics

Suction

Absorption - high, time to reach maximum concentration - 1-2.5 hours after oral administration.

Distribution

The distribution of ambroxol hydrochloride from the blood into the tissues occurs quickly and pronouncedly, with the most high concentration active substance is found in the lungs. The volume of distribution after oral administration is 552 l. Communication with blood plasma proteins - 90%, penetrates the blood-brain barrier, placental barrier, and is excreted in breast milk.

Metabolism and excretion

Metabolism - in the liver due to conjugation, forms dibromanthranilic acid (approximately 10% of the dose), glucuronic conjugates and several minor metabolites. Studies of human liver microsomes have shown that CYP3P4 is the predominant isoform responsible for the metabolism of ambroxol.

About 30% of the prescribed oral dose is eliminated as a result of first-pass metabolism.

The half-life is 10 hours. Total clearance is in the range of 660 ml/min, renal clearance accounts for approximately 8% of the total clearance.

Pharmacokinetics in special groups patients

Due to the fact that the drug is metabolized in the liver and excreted by the kidneys, in case of severe violation renal function, there may be an accumulation of ambroxol metabolites formed in the liver.

In patients with impaired liver function, the excretion of ambroxol hydrochloride is reduced, which leads to an increase in its level in the blood plasma by 1.3-2 times.

Studies have shown that the pharmacokinetics of ambroxol does not depend on age and gender and thus does not require dosage changes.

Food intake does not affect the bioavailability of ambroxol hydrochloride.

Indications for use

Acute and chronic diseases of the respiratory tract with the release of viscous sputum: acute and chronic bronchitis, pneumonia, chronic obstructive pulmonary disease, bronchial asthma with difficulty in sputum discharge, bronchiectasis.

Contraindications

Hypersensitivity to ambroxol or other components of the drug.

Pregnancy (1st trimester).

Rare hereditary intolerance to any component of the drug (see section “Precautions”).

Children under 2 years old.

Use Lazolvan with caution during pregnancy (II-III trimester) and lactation, with renal and/or liver failure.

Pregnancy and lactation

Preclinical trials and extensive clinical experience have not revealed undesirable consequences drug treatment during pregnancy. However, you should respect general rules appointments medicines during pregnancy. Lazolvan is not recommended during the first trimester of pregnancy.

Lazolvan penetrates into breast milk. Although it is not expected adverse effects drug for a child, Lazolvan is not recommended for use during breastfeeding.

Directions for use and doses

Syrup 15mg/5ml

Children 2-5 years old : 2.5 ml (7.5 mg ambroxol hydrochloride) 3 times a day (every 8 hours). The maximum dose is 22.5 mg ambroxol hydrochloride per day. After 2-3 days, if the patient feels better, LAZOLVAN can be taken 2 times a day, i.e. every 12 hours.

Children under 2 years old

Syrup 30 mg/5 ml

Adults : 10 ml (60 mg ambroxol hydrochloride) 2 times a day (every 12 hours). The maximum dose is 120 mg ambroxol hydrochloride per day.

If the patient feels better, the dose of Lazolvan can be halved.

Children over 12 years old : 5-7.5 ml (30-45 mg ambroxol hydrochloride) 2 times a day (every 12 hours). The maximum dose is 60-90 mg ambroxol hydrochloride per day.

Children 6-12 years old : 2.5 ml (15 mg ambroxol hydrochloride) 2-3 times a day. The maximum dose is 45 mg ambroxol hydrochloride per day. After 2-3 days, if the patient feels better, LAZOLVAN can be taken 2 times a day, i.e. every 12 hours.

Children 2-5 years old : 1.25 ml (7.5 mg ambroxol hydrochloride) 3 times a day (every 8 hours). The maximum dose is 22.5 mg ambroxol hydrochloride per day. After 2-3 days, if the patient feels better, LAZOLVAN can be taken 2 times a day, i.e. every 12 hours.

Children under 2 years old : This medicine is contraindicated for children under 2 years of age.

Patients with impaired renal or liver function

Patients with impaired renal function or severely impaired liver function should take the drug only as prescribed by a doctor and under the supervision of a doctor. In this case, you should either reduce the dose or increase the time between doses of the drug.

Missed dose

If you forget to take Lazolvan or take an insufficient amount, continue taking the medicine according to the dosage regimen.

Lazolvan can be taken regardless of meals.

If symptoms do not improve or worsen after 5 days of treatment, you should consult a doctor.

Side effect

From the immune system : anaphylactic reactions (including anaphylactic shock) and other hypersensitivity reactions.

From the nervous system : dysgeusia (impaired sense of taste).

From the respiratory system, organs chest and mediastinum : loss of sensitivity in the oral cavity and pharynx,

From the gastrointestinal tract : nausea, oral hypoesthesia, vomiting, diarrhea, dyspepsia, abdominal pain, dry mouth, dry throat, heartburn, constipation, hypersalivation.

From the skin and subcutaneous tissues : rash, urticaria, angioedema, itching.

From the kidneys and urinary tract : dysuria.

If the listed adverse reactions occur or a reaction not mentioned in the instructions for use, you should consult a doctor.

Overdose

Symptoms of overdose in humans have not been described. In case of accidental overdoses and/or cases medical errors the observed symptoms were reported to be consistent with known side effects Lazolvan when taken in recommended doses. Possible: nausea, vomiting, diarrhea, dyspepsia. Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug; intake of fat-containing foods, symptomatic therapy.

Interaction with other drugs

Compatible with drugs that inhibit labor. Concomitant use with antitussive drugs leads to difficulty in sputum discharge while reducing cough. Increases the penetration and concentration in bronchial secretions of amoxicillin, cefuroxime and erythromycin.

Precautionary measures

Several cases of severe skin damage, including Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported associated with mucolytic agents such as ambroxol hydrochloride. These cases can usually be explained by the severity concomitant disease or simultaneous administration other drugs. In addition, on early stage Stevens-Johnson syndrome and toxic epidermal necrolysis, patients may show signs of the onset of a nonspecific illness resembling influenza: fever, pain throughout the body, rhinitis, cough and sore throat. The appearance of these signs may lead to unnecessary symptomatic treatment anti-cold medications.

Therefore, if damage to the skin or mucous membranes occurs, consult a doctor immediately and treatment with ambroxol hydrochloride should be discontinued as a precaution.

In case of impaired renal function or severe impairment of liver function, Lazolvan should be taken only after consultation with a doctor. Due to the fact that the drug is metabolized in the liver and excreted by the kidneys, in cases of severe renal impairment, accumulation of ambroxol metabolites produced in the liver may occur.

When prescribing to children aged 2 to 6 years, the risk/benefit ratio should be taken into account.

Patients with impaired bronchial motility and copious bronchial secretions (as, for example, with rare syndrome primary ciliary dyskinesia), Lazolvan should be used with caution due to the risk of difficulty with the discharge of large amounts of sputum and blockage of the bronchi.

Lazolvan syrup 30 mg/5 ml: 5 ml of syrup contains 1.2 g of sorbitol, which is 4.9 g of sorbitol in the maximum recommended daily dose(20 ml). Patients with rare hereditary fructose intolerance should not take this drug.

For diseases of the respiratory system that occur with the release of viscous mucus, mucolytic agents are used to stimulate the discharge of sputum.

Lazolvan syrup is a mucolytic: the instructions for use recommend drinking it when respiratory diseases, at which it is observed.

In contact with

Composition of Lazolvan syrup

is a drug that has several forms - lozenges, tablets, inhalation solution and syrup. They are based on the active substance ambroxol, an expectorant.

Ambroxol hydrochloride has secretolytic and secretomotor properties: it first increases the amount of secretion from the respiratory tract, and then stimulates its release (expectoration).

The auxiliary components of Lazolvan syrup include benzoic acid, glycerol, water, hyaetellose, flavorings and liquid sorbitol. The drug does not contain sugar, so it can be taken by diabetics.

On sale Lazolvan cough syrup can be found in wild berry and strawberry flavors. The medicine is released in a glass bottle containing 15 or 30 mg of ambroxol per 5 ml of sweet solution.

Indications for use

You can take drugs according to the instructions for use for diseases respiratory organs accompanied by a wet cough with complicated sputum production:

• asthma;
• chronic pulmonary obstruction;
• cold.

Instructions for use for cough

Lazolvan cough syrup instructions for use recommend taking it orally for 4–5 days. During this period of time, the symptoms of the disease are expected to ease.

How to use?

How to take Lazolvan syrup for adults? According to the instructions for use, you need to drink it:

• 10 ml three times a day is adult dosage, acceptable for patients over 12 years of age;
• children over 6 years old should take 5 ml 2-3 times a day;
• patients over 2 years old can take the medicine 2.5 ml three times a day;
• Children under 2 years old are allowed to take 2.5 ml twice a day.

Before or after meals?

When is it better to take Lazolvan cough syrup - before or after meals? The instructions for use clearly indicate: regardless of food. You can take the medicine before meals, as well as some time after meals in the morning, lunch or evening.

special instructions

Special instructions in the instructions for use - how to take Lazolvan syrup - refer to possible side effects while taking drugs, as well as contraindications. You should not take the medicine if:

• pregnancy and breastfeeding;
• hypersensitivity to the components of the drug;
• renal failure;
• liver dysfunction.

Despite the fact that the manufacturer in the instructions for use allows taking the drug from the second trimester, it is recommended to refrain from taking it throughout pregnancy.

The ability of ambroxol to penetrate the placental barrier has been proven. Although there is no precise data on pathogenic effects substances on the fetus, there is still a risk of negative effects.

In the instructions for use, we also do not recommend drinking Ambroxol while breastfeeding, since the substance also passes into mother's breast milk.

Can it be used for dry cough?

The instructions for use do not allow Lazolvan syrup for dry coughs, since drugs of a different principle of action are used for this type of cough. The instructions for use do not contain instructions on how to take Lazolvan syrup for dry cough in adults and children.

Since the principle of action of Lazolvan is to reduce the viscosity of sputum and remove it out during a cold, it makes no sense to drink this medicine if you have a dry cough.

Reviews

Reviews about Lazolvan cough syrup are mostly positive. Patients positively evaluate the possibility of taking it by both adults and children. While other cough medicines have restrictions on permissible age For administration, the drug can be taken by children under 2 years of age. Reviews describe Lazolvan syrup as an easy-to-take medicine that has a sweet berry flavor.

Unlike drugs plant based, ambroxol shows pronounced therapeutic effect, while herbal-based drugs for the treatment of ARVI have, for the most part, a mild deodorizing and emollient effect.

Analogs

If you need to use drugs based on another active ingredient, you can look for an analogue of Lazolvan syrup among medicines plant origin. Medicines that have the same pharmacological action, can be called analogues.

Lazolvan has them as follows:

• Marshmallow syrup;
• (primrose root extract and thyme herb);
• Dr. Theiss with plantain;
• Licorice root syrup and others.

These medicines have significant difference from Lazolvan: they are based on medicinal plants, whereas the drug contains synthetic substance ambroxol. Other drugs with this substance are called synonyms, and this group includes:

• Ambroxol (Republic of Belarus);
• (Germany);
• (Hungary);
• Ambroxol Vramed (Bulgaria).

Other forms of the drug

Other forms of the medicine are also intended to accelerate the removal of mucus from the bronchi.

Solution for internal reception and inhalation of 7.5 mg/ml ambroxol in 100 ml bottles with a measuring cup (manufacturer: Instituto De Angeli).

Lazolvan for children is synonymous with the usual Lazolvan a, but with a reduced dosage - 15 mg/5 ml (manufactured by Boehringer Ingelheim Espana, Spain or Delpharm Reims, France).

Which is better - syrup or tablets?

All drugs for internal use act the same, regardless of the form in which the active substance is located. Therefore, the question of which is better - Lazolvan syrup or tablets - is subjective. The first one is better suited for children who like sweet taste berries The tablets provide the same therapeutic effect, but they contain 162.5 mg of lactose, which is not suitable for people with lactase deficiency. In another form of the drug there is no sugar, and sorbitol gives the sweet taste and viscosity, which can be taken by people with diabetes.

But there is also a strong argument in favor of tablets: treatment with their help is cheaper, because a bottle of medicine lasts a maximum of 3-4 days, and a pack of tablets is used up within 7-8 days.

Useful video

For more information on treating cough in adults, watch the following video:

Conclusion

1. Lazolvan syrup for adults and children - effective remedy against wet cough, which facilitates the release of sputum and shortens the period of taking antibiotics and other drugs for respiratory diseases.
2. The medicine can be taken by children from 2 years old at 2.5 mg twice a day or use the form children's drug Lazolvan.
3. The medicine is not used for dry cough, because in this case drugs of a different principle of action must be used.
4. There is no need to take Lazolvan during pregnancy and lactation, as well as hypersensitivity to ambroxol.