How to decipher the disease. Oncological diagnosis and treatment of cancer

Every patient wants to know what happened to him, and therefore, first of all, he wants to hear from the doctor the name of his illness, the diagnosis. However, to understand the tricky medical terms it can be difficult. In this case, certain information about what a particular disease is can be obtained directly from its name.

SO, there are many diseases whose names are derived from some anatomical term, usually Latin or Greek origin, and a word-forming element indicating a particular dysfunction of an organ or system. For example, the presence in the name of the Greek prefix “a” (before the vowels - “an”) means negation, the absence of some quality. These are diseases such as anemia("hema" - blood) - literally translated means "bloodlessness" (practically - "anemia"); asthenia("stenos" - strength) - literally "powerlessness", " general weakness"; atrophy("trophe" - nutrition) - lack of nutrition; arrhythmia- literally “no rhythm”, that is, any violation heart rate; anuria("urina" - urine) - "no urine", cessation of urination, etc.

If the name of the disease contains the Greek prefix “dis”, this means a disorder, difficulty in the function of one or another organ. The names of diseases such as dystrophy- eating disorders; dyskinesia(“kinesis” - movement) - violation contractile function digestive organs; dystonia("tonos" - tension) - violation nervous regulation vascular tone; dysbacteriosis("bacterion" - rod) - a violation of the biological balance between pathogenic and beneficial bacteria in the intestines; dysentery(“enteron” - intestine) - literally means “intestinal disorder”, etc.

When the name ends in "-itis", the disease usually has inflammatory nature. For example, arthritis("arthron" - joint) - inflammatory disease of the joint; gastritis(“gaster” - stomach) - inflammatory disease of the gastric mucosa; dermatitis("dermis" - skin) - inflammation of the skin; mastitis(“mastos” - breast) - inflammation of the mammary gland; nephritis(“nephros” - kidney) - inflammatory disease of the kidneys; phlebitis(“phlebos” - vein) - inflammation of the veins, etc.

Many oncological diseases can be identified by the presence in the name of the word-forming element “-oma”, meaning “tumor”. For example, angioma("angion" - vessel) - vascular tumor; myoma(“mios” - muscle) - tumor of muscle tissue; nephroma- malignant kidney tumor, etc.

The ending "-patiya" ("pathos" - illness, suffering) means common name diseases of any organ or system. For example, arthropathy- general name for joint diseases; nephropathy- kidney diseases; psychopathy("psyche" - soul, consciousness) - pathologies of character; cardiopathy("cardia" - heart) - heart disease, etc.

Often the name of the disease indicates its underlying cause. clinical symptom. For example, the presence of the word-forming element "-alg-" ("algos" - pain): neuralgia(“neoron” - nerve) - pain along the nerve; gastralgia- stomach ache; myalgia- muscle pain, etc. The names of diseases such as hemophilia(“hema” - blood and “philia” - tendency) - predisposition to bleeding; schizophrenia(“schizo” - splitting, splitting and “fren” - soul, mind, reason) - split personality; haemorrhoids("hema" - blood and "roa" - outflow) - discharge of blood, bleeding; hypertension(“hyper” - over, higher and “tonos” - tension) - increased tension blood vessels; angina(“ango” - soul) - suffocation; scarlet fever(“scarlatum” - bright red tissue) - redness of the mucous membrane of the oropharynx; stroke(“stroke” - blow) - characterizes the sudden onset of the disease, etc.

The name of the disease may indicate the underlying cause pathological process. For example, atherosclerosis("atere" - gruel and "skleros" - dense, hard) - a combination of thickening (sclerosis) of the inner lining of the artery and the accumulation of fatty substances in it, which over time acquire the appearance of gruel. Cardiac ischemia(“ischemia” - to delay, stop blood) - damage to the heart muscle caused by a disorder of coronary circulation; caries(“rotting”) - destruction of tooth tissue.

From some names you can also find out the direct cause of the disease. For example, title "hay fever"(“pollen” - pollen) indicates the connection of this disease with plant pollen; brucellosis- disease caused by various types of Brucella; leptospirosis- disease caused by Leptospira, etc.

There are also more complex names. For example, myocardial dystrophy(“myos” - muscle, “cardia” - heart, “dystrophe” - nutritional disorder) - non-inflammatory damage to the heart muscle in the form of a violation of its nutrition. In the name of the disease "Tick-borne Lyme borreliosis" the carrier (tick), pathogen (Borrelia) and the place where this disease was first described (Lyme in the USA) are indicated. And from the title "tick-borne encephalitis" you can learn that the main pathological process of this disease is inflammation of the brain (“encephalon” means brain, and the ending “-itis” means inflammation) and that the causative agent of the disease is carried by ticks.

However, there are a number of diseases whose names do not reflect their true essence. The fact is that these names appeared at a time when the true causes of many diseases were not yet known. But despite this, some of these names are still used to refer to a number of diseases. For example, glaucoma("glaukos" - bluish) literally means "bluish clouding of the lens", although, as is known, the basis of this disease is an increase in intraocular pressure.

The name of such a disease as "gonorrhea", characteristic symptom which are purulent discharge. But when the Roman physician Galen in the 2nd century AD. e. proposed this name, they believed that the essence of the disease lies in the leakage of seminal fluid: translated from Greek, “gonorrhea” means “ejaculation” (“gonos” - seed and “roe” - discharge). And although it was later found that pus is released in this case, the original name remained.

The occurrence of a disease such as "hysteria", Ancient Greek doctors associated it with disorders of the uterus. Hence the name "hysteria", derived from the Greek. "hystera" - uterus. But even after it was proven that the symptoms characteristic of this disease depend on a disorder of the nervous system, the term “hysteria” continues to be used to designate a neuropsychic disease related to neuroses.

For more than two millennia, it was believed that prolonged inhalation of heavy swamp fumes causes a disease, which in connection with this received the name "malaria"(from the Italian “malya aria” - bad air). And although it later became clear the real reason its origin, the old name has been preserved to this day.

18.03.2016 10:34:45

In this section we will answer questions such as: What is the stage of cancer? What are the stages of cancer? What's happened initial stage cancer? What is stage 4 cancer? What is the prognosis for each stage of cancer? What do the letters TNM mean when describing the stage of cancer?
When a person is told that he has been diagnosed with cancer, the first thing he wants to know is: stage And forecast. Many cancer patients are afraid to find out the stage of their disease. Patients are afraid of stage 4 cancer, thinking that this is a death sentence and the prognosis is only unfavorable. But in modern oncology early stage does not guarantee a good prognosis, just as a late stage of the disease is not always synonymous with an unfavorable prognosis. There are many side factors that affect the prognosis and course of the disease. These include (mutations, Ki67 index, cell differentiation), its localization, the type of metastases detected.

Staging tumors into groups depending on their prevalence is necessary to take into account data on tumors of a particular location, treatment planning, taking into account prognostic factors, assessing treatment results and monitoring malignant neoplasms. In other words, determining the stage of cancer is necessary in order to plan the most effective treatment tactics, as well as for the work of statisticians.

TNM classification

Exists a special staging system for each cancer disease, which is accepted by all national health committees, is TNM classification of malignant neoplasms, which was developed by Pierre Denoit in 1952. With the development of oncology, it has gone through several revisions, and at the moment the seventh edition, published in 2009, is current. It contains the latest rules for the classification and staging of cancer.
The TNM classification for describing the prevalence of neoplasms is based on 3 components:
  • First - T(lat. Tumor- tumor). This indicator determines the extent of the tumor, its size, and growth into surrounding tissues. Each location has its own gradation from the smallest tumor size ( T0), to the largest ( T4).
  • Second component - N(lat. Nodus- node), it indicates the presence or absence of metastases in the lymph nodes. Just as in the case of the T component, each tumor location has its own rules for determining this component. The gradation comes from N0(absence of affected lymph nodes), up to N3(widespread lesion lymph nodes).
  • Third - M(Greek Metastasis- movement) – indicates the presence or absence of distant metastases to various organs. The number next to the component indicates the degree of prevalence of the malignant neoplasm. So, M0 confirms the absence of distant metastases, and M1- their presence. After the designation M, the name of the organ in which distant metastasis was detected is usually written in parentheses. For example M1 (oss) means that there are distant metastases in the bones, and M1 (bra)- that metastases were found in the brain. For other organs, use the designations given in the table below.

Also, in special situations, an additional letter is placed before the TNM designation. These are additional criteria indicated by the symbols “c“, “р”, “m”, “y”, “r” And "a".

- Symbol "c" means that the stage is established according to non-invasive examination methods.

- Symbol "p" says that the stage of the tumor was established after surgery.

- "m" symbol used to refer to cases where several primary tumors are located in the same area.

- Symbol "y" used in cases where the tumor is assessed during or immediately after antitumor treatment. The prefix "y" takes into account the extent of the tumor before complex treatment. Values ycTNM or ypTNM characterize the extent of the tumor at the time of diagnosis using non-invasive methods or after surgery.

- "r" symbol used in the assessment of recurrent tumors after a relapse-free period.

- Character "a", used as a prefix, indicates that the tumor is classified after autopsy (autopsy after death).

Histological classification of cancer stages

In addition to the TNM classification, there is classification according to histological features of the tumor. They call her degree of malignancy (Grade, G). This sign indicates how active and aggressive the tumor is. The degree of tumor malignancy is indicated as follows:
  • GX- the degree of tumor differentiation cannot be determined (little data);
  • G1- highly differentiated tumor (non-aggressive);
  • G2- moderately differentiated tumor (moderately aggressive);
  • G3- low-grade tumor (highly aggressive);
  • G4- undifferentiated tumor (highly aggressive);
The principle is very simple - the higher the number, the more aggressive and active the tumor behaves. IN Lately grades G3 and G4 are usually combined into G3-4, and this is called “poorly differentiated - undifferentiated tumor.”
Only after the tumor has been classified according to the TNM system can grouping by stages be performed. Determining the extent of spread of the tumor process according to the TNM system or stages is very important for the selection and assessment of the necessary treatment methods, while histological classification allows us to obtain the most exact specifications tumors and predict the prognosis of the disease and possible response to treatment.

Determination of cancer stage: 0 - 4

Determining the stage of cancer directly depends on the TNM classification of the cancer. Based on TNM staging, most tumors are staged as described in the table below, but each cancer location has different staging requirements. We will look at the simplest and most common examples.

Traditionally Stages of cancer are usually designated from 0 to 4. Each stage, in turn, can have the letter designations A and B, which divides it into two more substages, depending on the prevalence of the process. Below we will look at the most common stages of cancer.

We would like to draw your attention to the fact that in our country many people like to say “grade of cancer” instead of “stage of cancer.” Various websites contain questions about: “grade 4 cancer”, “survival rate for stage 4 cancer”, “grade 3 cancer”. Remember - there are no degrees of cancer, there are only stages of cancer, which we will discuss below.

Stages of cancer using the example of an intestinal tumor

Stage 0 cancer

As such, stage 0 does not exist; it is called "cancer is in place" "carcinoma in situ"- which means non-invasive tumor. Stage 0 can be for cancer of any location.

At stage 0 cancer, the boundaries of the tumor do not extend beyond the epithelium that gave rise to the tumor. With early detection and timely initiation of treatment, the prognosis for stage 0 cancer is almost always favorable, that is Stage 0 cancer is completely curable in the vast majority of cases.

Stage 1 cancer

The first stage of cancer is characterized by a fairly large tumor node, but the absence of damage to the lymph nodes and the absence of metastases. Recently, there has been a trend towards an increase in the number of tumors detected at stage 1, which indicates the awareness of people and the good quality of diagnosis. The prognosis for the first stage of cancer is favorable, the patient can count on a cure, the main thing is to start adequate treatment as quickly as possible.

Stage 2 cancer

Unlike the first, at the second stage of cancer the tumor is already active. The second stage of cancer is characterized by an even larger tumor size and its growth into surrounding tissues, as well as the beginning of metastasis to the nearest lymph nodes.

Stage 2 cancer is considered the most common stage of cancer at which cancer is diagnosed. The prognosis for stage 2 cancer depends on many factors, including the location and histological features of the tumor. In general, stage 2 cancer can be successfully treated.

Stage 3 cancer

At the third stage of cancer occurs active development oncological process. The tumor reaches even larger sizes, growing into nearby tissues and organs. At the third stage of cancer, metastases to all groups of regional lymph nodes are already reliably determined.
The third stage of cancer does not involve distant metastases to various organs, which is positive thing and determines a favorable prognosis.
The prognosis for stage 3 cancer is influenced by factors such as: location, degree of tumor differentiation and general condition of the patient. All these factors can either aggravate the course of the disease, or, conversely, help prolong the life of a cancer patient. To the question whether stage 3 cancer is curable, the answer will be negative, since at such stages cancer already becomes a chronic disease, but can be successfully treated.

Stage 4 cancer

Stage four cancer is considered the most serious stage of cancer. The tumor can reach impressive sizes, invade surrounding tissues and organs, and metastasize to the lymph nodes. In stage 4 cancer, distant metastases are required, in other words, metastatic organ damage.

There are rare cases when stage 4 cancer can be diagnosed in the absence of distant metastases. Large, poorly differentiated, fast-growing tumors are also often classified as stage 4 cancer. There is no cure for stage 4 cancer, as well as for stage 3 cancer. At the fourth stage of cancer, the disease takes on a chronic course, and it is only possible to put the disease into remission.

  • . Concern about unmanageable side effects (such as constipation, nausea, or confusion. Concern about addiction to pain medications. Non-adherence to prescribed pain medication regimen. Financial barriers. Health system issues: Low priority for cancer pain management. Most suitable treatment may be too expensive for patients and their families. Tight regulation of controlled substances. Problems with access to or availability of treatment. Opiates not available over the counter to patients. Unavailable medications. Flexibility is key to managing cancer pain. Since patients differ in diagnosis, stage of disease, response to pain and personal preferences, it is necessary to be guided by these characteristics. Read more in the following articles: ">Cancer pain 6
  • to cure or at least stabilize the development of cancer. Like other therapies, choice in use radiation therapy treatment for a specific cancer depends on a number of factors. These include, but are not limited to, the type of cancer, physical state patient, cancer stage, and tumor location. Radiation therapy (or radiotherapy is an important technology for shrinking tumors. High energy waves are directed at the cancerous tumor. The waves cause damage to cells, disrupting cellular processes, preventing cell division, and ultimately lead to the death of malignant cells. The death of even part of the malignant cells leads to One significant disadvantage of radiation therapy is that the radiation is not specific (that is, it is not directed exclusively at cancer cells for cancer cells and can also harm healthy cells. The response of normal and cancer tissue to therapy The response of tumor and normal tissue to radiation depends on their growth pattern before the start of therapy and during treatment. Radiation kills cells through interaction with DNA and other target molecules. Death does not occur instantly, but occurs when cells try to divide, but as a result of exposure to radiation, a failure occurs in the division process, which is called abortive mitosis. For this reason, radiation damage occurs more quickly in tissues containing cells that divide quickly, and cancer cells are the ones that divide quickly. Normal tissues compensate for the cells lost during radiation therapy by speeding up the division of remaining cells. In contrast, tumor cells begin to divide more slowly after radiation therapy, and the tumor may shrink in size. The extent of tumor shrinkage depends on the balance between cell production and cell death. Carcinoma is an example of a type of cancer that often has a high rate of division. These types of cancer tend to respond well to radiation therapy. Depending on the dose of radiation used and the individual tumor, the tumor may begin to grow again after stopping therapy, but often more slowly than before. To prevent tumor regrowth, radiation is often given in combination with surgical intervention and/or chemotherapy. Goals of Radiation Therapy Curative: For curative purposes, radiation exposure is usually increased. Reaction to radiation ranges from mild to severe. Symptom relief: This procedure is aimed at relieving cancer symptoms and prolonging survival, creating a more comfortable living environment. This type of treatment is not necessarily performed with the intention of curing the patient. Often this type of treatment is prescribed to prevent or eliminate pain caused by cancer that has metastasized to the bones. Radiation instead of surgery: Radiation instead of surgery is an effective tool against a limited number of cancer diseases. Treatment is most effective if the cancer is found early, while it is still small and non-metastatic. Radiation therapy may be used instead of surgery if the location of the cancer makes surgery difficult or impossible to perform without serious risk to the patient. Surgery is preferred method treatments for lesions that are located in an area where radiation therapy may do more harm than surgery. The time required for the two procedures is also very different. Surgery can be performed quickly after diagnosis; Radiation therapy may take weeks to be fully effective. There are pros and cons to both procedures. Radiation therapy may be used to save organs and/or avoid surgery and its risks. Radiation destroys rapidly dividing cells in the tumor, while surgical procedures may miss some of the cancerous cells. However, large tumor masses often contain oxygen-poor cells in the center that do not divide as quickly as cells near the surface of the tumor. Because these cells do not divide rapidly, they are not as sensitive to radiation therapy. For this reason, large tumors cannot be destroyed using radiation alone. Radiation and surgery are often combined during treatment. Useful articles for a better understanding of radiation therapy: ">Radiation Therapy 5
  • Skin reactions with targeted therapy Skin problems Shortness of breath Neutropenia Nervous system disorders Nausea and vomiting Mucositis Menopausal symptoms Infections Hypercalcemia Male sex hormone Headaches Hand-foot syndrome Hair loss (alopecia Lymphedema Ascites Pleurisy Edema Depression Cognitive problems Bleeding Loss of appetite Restlessness and anxiety Anemia Confusion. Delirium Difficulty swallowing Dysphagia Dry mouth Xerostomia Neuropathy For specific side effects, read the following articles: "> Side effects36
  • cause cell death in various directions. Some of the drugs are natural compounds that have been identified in various plants, while others chemical substances are created in laboratory conditions. Some various types chemotherapy drugs are briefly described below. Antimetabolites: Drugs that can affect the formation of key biomolecules inside the cell, including nucleotides, the building blocks of DNA. These chemotherapeutic agents ultimately interfere with the process of replication (production of daughter DNA molecule and hence cell division. Examples of antimetabolites include the following drugs: Fludarabine, 5-Fluorouracil, 6-Thioguanine, Ftorafur, Cytarabine. Genotoxic drugs: Drugs that can damage DNA. By causing this damage, these agents interfere with DNA replication and cell division. As an example of drugs: Busulfan, Carmustine, Epirubicin, Idarubicin. Spindle inhibitors (or mitosis inhibitors): These chemotherapy agents aim to prevent proper cell division by interacting with cytoskeletal components that allow one cell to divide into two parts. An example is the drug paclitaxel, which is obtained from the bark of the Pacific Yew and semi-synthetically from the English Yew ( Yew berry, Taxus baccata... Both drugs are prescribed as a series intravenous injections. Other chemotherapeutic agents: These agents inhibit cell division through mechanisms not covered in the three categories above. Normal cells are more resistant to drugs because they often stop dividing under conditions that are not favorable. However, not all normal dividing cells avoid the effects of chemotherapy drugs, which is evidence of the toxicity of these drugs. Cell types that typically divide rapidly, such as those in the bone marrow and in the lining of the intestines, tend to be affected the most. Normal cell death is one of the common side effects of chemotherapy. More details about the nuances of chemotherapy in the following articles: ">Chemotherapy 6
    • and non-small cell lung cancer. These types are diagnosed based on how the cells look under a microscope. Based on the established type, treatment options are selected. To understand the prognosis of the disease and survival rate, I present statistics from open US sources for 2014 on both types of lung cancer together: New cases of the disease (prognosis: 224210 Number of projected deaths: 159260 Let us consider in detail both types, specifics and treatment options.">Lung cancer 4
    • in the United States in 2014: New cases: 232,670 Deaths: 40,000 Breast cancer is the most common non-cutaneous cancer among women in the United States (public sources, an estimated 62,570 cases of preinvasive disease (in situ, 232,670 new cases of invasive disease, and 40,000 deaths. Thus, less than one in six women diagnosed with breast cancer will die from the disease. By comparison, an estimated 72,330 American women will die from lung cancer in 2014. Breast cancer glands in men (yes, yes, there is such a thing, it accounts for 1% of all cases of breast cancer and mortality from this disease. Widespread screening has increased the incidence of breast cancer and changed the characteristics of detected cancer. Why has it increased? Yes, because the use of modern methods has made it possible to detect incidence of low-risk cancers, premalignant lesions and ductal cancer in situ (DCIS). Population-based studies in the US and UK show an increase in DCIS and the incidence of invasive breast cancer since 1970, this is associated with the widespread use of postmenopausal hormone therapy and mammography. In the last decade, postmenopausal women have refrained from using hormones and the incidence of breast cancer has decreased, but not to the level that can be achieved with the widespread use of mammography. Risk and protective factors Increasing age is the most important risk factor for breast cancer. Other risk factors for breast cancer include the following: Family medical history o Underlying genetic susceptibility Sex mutations in the BRCA1 and BRCA2 genes, and other breast cancer susceptibility genes Alcohol consumption Breast tissue density (mammographic) Estrogen (endogenous: o Menstrual history (onset of menstruation / late menopause o No history of childbirth o Elderly age at the birth of the first child History of hormonal therapy: o Combination of estrogen and progestin (HRT Oral contraception Obesity No physical exercise Personal History of Breast Cancer Personal History proliferative forms benign diseases breast Radiation exposure to the breast Of all women with breast cancer, 5% to 10% may have germline mutations in the BRCA1 and BRCA2 genes. Research has shown that specific BRCA1 and BRCA2 mutations are more common among women of Jewish descent. Men who carry the BRCA2 mutation also have increased risk development of breast cancer. Mutations in both the BRCA1 and BRCA2 genes also create an increased risk of developing ovarian cancer or other primary cancers. Once BRCA1 or BRCA2 mutations have been identified, it is advisable for other family members to undergo genetic counseling and testing. Protective factors and measures to reduce the risk of breast cancer include the following: Using estrogen (especially after a hysterectomy Creating an exercise habit Early pregnancy Breast-feeding Selective estrogen receptor modulators (SERMs) Aromatase inhibitors or inactivators Reducing the risks of mastectomy Reducing the risk of oophorectomy or oophorectomy Screening Clinical trials have established that screening asymptomatic women with mammography, with or without clinical examination breast, reduces mortality from breast cancer. Diagnosis If breast cancer is suspected, the patient usually must go through the following steps: Confirmation of the diagnosis. Assessment of the stage of the disease. Choice of therapy. The following tests and procedures are used to diagnose breast cancer: Mammography. Ultrasound. Breast magnetic resonance imaging (MRI, if clinically indicated. Biopsy. Contralateral breast cancer Pathologically, breast cancer can be multicentric and bilateral. Bilateral disease is slightly more common in patients with invading focal carcinoma. Within 10 years of diagnosis, risk primary cancer breast in the contralateral breast ranges from 3% to 10%, although endocrine therapy may reduce this risk. Development of second breast cancer is associated with an increased risk of distant recurrence. If the BRCA1/BRCA2 gene mutation was diagnosed before the age of 40, the risk of cancer of the second breast in the next 25 years reaches almost 50%. Patients diagnosed with breast cancer should undergo bilateral mammography at the time of diagnosis to rule out synchronous disease. The role of MRI in screening for contralateral breast cancer and monitoring women treated with breast conservation therapy continues to evolve. Because the increased level detection of possible disease on mammography has been demonstrated, selective use of MRI for additional screening is occurring more frequently, despite the lack of randomized controlled data. Because only 25% of MRI-positive findings represent malignancy, pathological confirmation is recommended before treatment. Whether this increased rate of disease detection will lead to improved treatment outcomes is unknown. Prognostic Factors Breast cancer is usually treated with various combinations of surgery, radiation therapy, chemotherapy and hormonal therapy. Conclusions and selection of therapy may be influenced by the following clinical and pathological features (based on conventional histology and immunohistochemistry: Menopausal status of the patient. Stage of disease. Grade of primary tumor. Tumor status depending on the status of estrogen receptors (ER and progesterone receptors (PR). Histological types Breast cancer is classified into different histological types, some of which have prognostic significance. For example, favorable histological types include colloid, medullary and tubular cancer. Uses of molecular profiling in breast cancer include the following: ER and PR status testing. Receptor testing HER2/Neu status. Based on these results, breast cancer is classified as: Hormone receptor positive. HER2 positive. Triple negative (ER, PR, and HER2/Neu negative. Although some rare inherited mutations, such as BRCA1 and BRCA2, predispose to the development of breast cancer in carriers of the mutation, however, prognostic data on carriers of the BRCA1 / BRCA2 mutation are contradictory; these women are simply at greater risk of developing second breast cancer. But it is not a fact that this can happen. Hormone replacement therapy After careful consideration, patients with severe symptoms may be treated with hormone replacement therapy. Follow-up Frequency of follow-up and advisability of screening after completion primary treatment Stage I, stage II, or stage III breast cancer remains controversial. Data from randomized trials show that periodic follow-up with bone scans, liver ultrasound, chest x-rays and blood tests for liver function does not improve survival or quality of life at all compared with routine health checks. Even when these tests allow early detection of relapse of the disease, this does not affect the survival of patients. Based on these data, limited screening and annual mammography may be an acceptable continuation for asymptomatic patients who have been treated for stage I to III breast cancer. More detailed information in the articles: "> Mammary cancer5
    • , ureters, and proximal urethra are lined by a specialized mucosa called transitional epithelium (also called urothelium. Most cancers that form in the bladder, renal pelvis, ureters, and proximal urethra are transitional cell carcinomas (also called urothelial carcinomas, derived from transitional epithelium Transitional cell carcinoma Bladder may be low-grade or full-grade: Low-grade bladder cancer often recurs in the bladder after treatment, but rarely invades the muscle walls of the bladder or spreads to other parts of the body. Patients rarely die from low-grade bladder cancer. Full-blown bladder cancer usually recurs in the bladder and also has a strong tendency to invade the muscular walls of the bladder and spread to other parts of the body. High-grade bladder cancer is considered more aggressive than low-grade bladder cancer and is much more likely to cause death. Almost all deaths from bladder cancer are due to high-grade cancer. Bladder cancer is also divided into muscle-invasive and non-muscle-invasive disease, based on invasion of the muscle lining (also referred to as the detrusor muscle, which is located deep in the muscle wall of the bladder. Muscle-invasive disease is much more likely to spread to other parts of the body and is typically treated by either removing the bladder or treating the bladder with radiation and chemotherapy.As noted above, high-grade cancers are much more likely to be muscle-invasive cancers than low-grade cancers.Thus, Muscle-invasive cancer is generally considered to be more aggressive than non-muscle-invasive cancer.Non-muscle-invasive disease can often be treated by removing the tumor using a transurethral approach and sometimes chemotherapy or other procedures in which a drug is injected into the urinary cavity bladder with a catheter to help fight cancer. Cancer can occur in the bladder in the setting of chronic inflammation, such as a bladder infection caused by the parasite haematobium Schistosoma, or as a result of squamous metaplasia; Frequency squamous cell carcinoma bladder function is higher in conditions of chronic inflammation than otherwise. In addition to transitional carcinoma and squamous cell carcinoma, adenocarcinoma can form in the bladder, small cell carcinoma and sarcoma. In the United States, transitional cell carcinomas account for the vast majority (more than 90% of bladder cancers. However, a significant number of transitional cell carcinomas have areas of squamous cell or other differentiation. Carcinogenesis and Risk Factors There is compelling evidence of the influence of carcinogens on the occurrence and development of bladder cancer. The most common risk factor for developing bladder cancer is cigarette smoking. It is estimated that up to half of all bladder cancer cases are caused by smoking and that smoking increases the risk of developing bladder cancer at two to four times the baseline risk. Smokers with less functional polymorphisms N-acetyltransferase-2 (known as the slow acetylator) has more high risk development of bladder cancer compared with other smokers, apparently due to a decreased ability to detoxify carcinogens. Some occupational hazards have also been linked to bladder cancer, and higher rates of bladder cancer have been reported due to textile dyes and rubber in the tire industry; among artists; leather processing industry workers; from shoemakers; and aluminum, iron and steel workers. Specific chemicals associated with bladder carcinogenesis include beta-naphthylamine, 4-aminobiphenyl, and benzidine. Although these chemicals are now generally banned in Western countries, many other chemicals that are still used today are also suspected of causing bladder cancer. Exposure to the chemotherapy agent cyclophosphamide has also been associated with an increased risk of bladder cancer. Chronic urinary tract infections and infections caused by the parasite S. haematobium are also associated with an increased risk of developing bladder cancer, and often squamous cell carcinoma. Chronic inflammation, is believed to play a key role in the process of carcinogenesis in these conditions. Clinical features Bladder cancer usually presents with simple or microscopic hematuria. Less commonly, patients may complain of frequent urination, nocturia, and dysuria, symptoms that are more common in patients with carcinoma. Patients with urothelial cancer of the upper urinary tract may experience pain due to obstruction by the tumor. It is important to note that urothelial carcinoma is often multifocal, necessitating examination of the entire urothelium if a tumor is detected. In patients with bladder cancer, imaging of the upper urinary tract is essential for diagnosis and follow-up. This can be achieved using urethroscopy, retrograde pyelogram in cystoscopy, intravenous pyelogram, or computed tomography (CT urogram). In addition, patients with transitional cell carcinoma of the upper urinary tract have a high risk of developing bladder cancer; these patients require periodic cystoscopy and monitoring the opposite upper urinary tract.Diagnosis When bladder cancer is suspected, the most useful diagnostic test is cystoscopy. Radiological examination such as CT scan or Ultrasounds are not sensitive enough to be useful for detecting bladder cancer. Cystoscopy can be performed in urological clinic. If cancer is detected during cystoscopy, the patient is typically scheduled for a bimanual examination under anesthesia and a repeat cystoscopy in the operating room so that transurethral tumor resection and/or biopsy can be performed. Survival Patients who die from bladder cancer almost always have metastases from the bladder to other organs. Low-grade bladder cancer rarely grows into the muscle wall of the bladder and rarely metastasizes, so low-grade (stage I) bladder cancer patients very rarely die from the cancer. However, they may experience multiple recurrences that should be treated resection. Almost all deaths from bladder cancer occur among patients with disease with high level malignancy, which has a much greater potential to invade deep into the muscular walls of the bladder and spread to other organs. Approximately 70% to 80% of patients with newly diagnosed bladder cancer have superficial bladder tumors (ie, stage Ta, TIS, or T1. The prognosis of these patients depends largely on the grade of the tumor. Patients with high-grade tumors are at significant risk die from cancer, even if it is not muscle-invasive cancer. Those patients with high-grade tumors who are diagnosed with superficial, non-muscle-invasive bladder cancer in most cases have a high chance of cure, and even in the presence of muscle-invasive disease sometimes The patient can be cured.Studies have shown that in some patients with distant metastases, oncologists achieved long-term complete responses after treatment with a combination chemotherapy regimen, although in most of these patients the metastases are limited to their lymph nodes. Secondary cancer Bladder Cancer tends to recur, even if it is non-invasive at the time of diagnosis. Therefore, standard practice is to perform urinary tract surveillance after a diagnosis of bladder cancer. However, no studies have yet been conducted to evaluate whether surveillance affects progression rates, survival, or quality of life; although there is clinical trials to determine the optimal observation schedule. Urothelial carcinoma is believed to reflect a so-called field defect in which the cancer arises due to genetic mutations, which are widely present in the patient's bladder or throughout the urothelium. Thus, people who have had a resected bladder tumor often subsequently have ongoing tumors in the bladder, often in other locations than the primary tumor. Similarly, but less frequently, they may develop tumors in the upper urinary tract(i.e., in renal pelvis or ureters. An alternative explanation for these patterns of relapse is that cancer cells that are destroyed during tumor excision may reimplant elsewhere in the urothelium. Support for this second theory is that tumors are likely to recur lower than in the opposite direction from the initial cancer. Upper tract cancer is more likely to recur in the bladder than bladder cancer to recur in the upper tract. The rest is in the following articles: "> Bladder cancer4
    • , as well as an increased risk of metastatic disease. The degree of differentiation (determining the stage of tumor development has an important influence on natural history this disease and the choice of treatment. Increased incidence of endometrial cancer has been found to be associated with long-term, unopposed estrogen exposure (increased levels. In contrast, combination therapy(estrogen + progesterone prevents an increase in the risk of developing endometrial cancer associated with a lack of resistance to the effects of estrogen specifically. Receiving a diagnosis is not the best time. However, you should know that endometrial cancer is a curable disease. Monitor the symptoms and everything will be fine! In some patients, A previous history of complex hyperplasia with atypia may play a role as an "activator" of endometrial cancer. An increase in the incidence of endometrial cancer has also been found in association with tamoxifen treatment for breast cancer. According to researchers, this is due to the estrogenic effect of tamoxifen on the endometrium. Due to this increase, Patients who are prescribed therapy with tamoxifen must undergo regular examinations of the pelvic area and must be attentive to any pathological uterine bleeding. Histopathology The distribution pattern of malignant endometrial cancer cells depends in part on the degree of cellular differentiation. Well differentiated tumors, as a rule, limit their spread to the surface of the uterine mucosa; myometrial expansion occurs less frequently. In patients with poorly differentiated tumors, invasion of the myometrium is much more common. Invasion of the myometrium is often a precursor to lymph node involvement and distant metastases, and often depends on the grade of differentiation. Metastasis occurs in the usual way. Spread to the pelvic and para-aortic nodes is common. When distant metastases occur, it most often occurs in: Lungs. Inguinal and supraclavicular nodes. Liver. Bones. Brain. Vagina. Prognostic factors Another factor that is associated with ectopic and nodal spread of the tumor is the participation of the capillary-lymphatic space in histological examination. The three prognostic groupings of clinical stage I were made possible by careful operative staging. Patients with stage 1 tumors that involve only the endometrium and have no evidence of intraperitoneal disease (i.e., extension to the adnexa) low risk(">Endometrial cancer 4
  • Petrov's disease
    The term was used earlier, by old oncologists, very broadly. Usually it meant stomach cancer (although in principle it could mean any malignant tumor). It has not been widely used for a long time. In general, the surname “Petrov” was often used in oncology in various slang terms, meaning the surname of the oncologist - academician N.N. Petrova.

    cancer, c-r, Blastoma, Bl., NEO, neoplasma (neoplasm), Disease...., Tumor (tumor)
    All of the above terms refer to a malignant tumor, usually cancer. They are all used to avoid writing the word “cancer” in plain text. To refer to sarcoma, another abbreviation is more often used - SA (Sa).

    Trial laparotomy, Laparotomia explorativa, Petrov's operation, Explorative resection (of something)
    All terms denote a situation when the “opening” of the abdomen reveals inoperability, advanced tumor, stage 4 cancer, in which it is pointless to perform any intervention. After this, the stomach is sutured without performing any surgery. Among doctors, slang expressions such as “test”, “to hammer” are often used.

    Palliative surgery, palliative resection (of something)
    Palliative surgery (not radical) is an operation in which the neglect and inoperability of the tumor is also established, but some kind of intervention is performed - either in order to eliminate some complication (bleeding, stenosis, etc.), or in the hope of achieving temporary remission , especially if subsequent chemotherapy or radiation treatment(also palliative, that is, not radical).

    Symptomatic treatment at the place of residence
    A phrase that encodes that the patient has an inoperable, advanced tumor, usually stage 4, and that such a patient, therefore, is not subject to special types radical treatment from a specialist - oncologist. Involves prescribing medicines, only alleviating the condition of an incurable patient, and, first of all, narcotic analgesics as needed. Among doctors, the slang expressions “symptoms” and “symptomatic patient” are often used. Can be considered synonymous with clinical group 4 of dispensary registration.

    Generalization (dissemination)
    A term denoting an advanced tumor in which there are many regional and/or distant metastases. As a rule, we are talking about stage 4 of the tumor process and clinical group 4 of dispensary registration.

    Progression
    The term denotes the continuation of tumor aggression, the continued growth of cancer. Common progression of untreated cancer. However, progression can also occur after treatment special treatment according to a radical program. In such a situation, it is the antonym of the word “remission”. Moreover, the timing of progression can be very variable - continued growth of cancer cells after treatment can occur after 1 - 2 months, and after 10 - 20 - 30 years. (The longest period of occurrence of progression from the end of treatment that I found in the literature was 27 years).

    Secondary hepatitis (pulmonitis, lymphadenitis, etc.), secondary hepatitis (pulmonitis, lymphadenitis, etc.)
    All terms indicate the presence of distant metastases (liver, lungs, lymph nodes, etc.). Indicates an advanced tumor, stage 4 cancer.

    Virchow's lymphadenitis
    Virchow's metastasis (cancer metastasis to the supraclavicular lymph node on the left - after the name of the author who first described it) Indicates the advanced stage of the tumor, stage 4 cancer.

    mts
    Metastasis (short for Latin - metastasis). It can indicate both regional and distant metastases.

    prima, secunda, tercia, qarta (prima, second, third, quart)
    Latin words are numerals. They indicate the stage of development of cancer, the tumor process - first, second, third and fourth. Among physicians, incurable patients are often referred to by the slang term “quart.”

    T.... N.... M....
    An abbreviation of Latin words used in the international classification of malignant tumors by stage. T- Tumor - primary tumor, values ​​can be from 1 to 4 depending on size; N - Nodulus - nodes (lymphatic), values ​​can be from 1 to 2-3 depending on the level of damage to regional lymph nodes; M - Metastasis - metastases, meaning distant metastases, values ​​can be 0 or 1 (+), that is, distant metastases are present or not. For all categories (TNM) the value may be x (x) - the available data is insufficient for an estimate.

    Difference between stage and clinical group
    Often patients, even in long-term remission, panic when they hear the term “3 clinical group", considering this to be stage 3 of the development of the tumor process. This is incorrect. "Clinical groups" are groups dispensary observation, and their numerical designation has no correlation with the stage of tumor development.
    1 clinical group - patients with underlying precancerous diseases, subject to dispensary observation;
    Clinical group 2 - patients with cancer of any stage, subject to special types of treatment (surgical, radiation, chemo-hormonal);
    3 clinical group - radically cured cancer patients;
    Clinical group 4 - incurable patients, patients with advanced malignant tumors who are not subject to special types of treatment.
    As you can see, clinical group 3 indicates a very good option.

    Adequate pain relief
    This phrase usually “hides” the recommendation to prescribe narcotic analgesics for relief pain syndrome. However, the problem of pain management for incurable patients is much more complex and broader than simply prescribing drugs.

    Palliative radiation (chemotherapy)
    Palliative chemotherapy, palliative radiation - non-radical use of these techniques. That is, a situation when specific treatment is performed on a patient who is known to be incurable with a deliberately non-radical purpose, either to relieve any complications and improve the quality of the remaining life, or in the hope of at least temporary stabilization of the tumor process. The concept of palliation corresponds to that of surgical treatment.

    What does sick leave mean? With the help of a sick leave certificate, an illness, injury or other physiological problem of an employee is registered. The form is sometimes called differently - a sheet of temporary incapacity for work. It is allowed to be prescribed only by doctors who have passed a special check by the FSS. An employee can count on payments if the form was correctly filled out and submitted to the enterprise administration within the established time frame.

    For a long time now, a single standardized form has been used to fill out sick leave. In 2011, a reform was carried out in this area, the forms began to look slightly different, and new rules for filling out were introduced. Disease codes have become strictly mandatory.

    Is the diagnosis written in sick leave? The diagnosis and cause of disability are now indicated using two special digital designations. The first is the national designation of the reason (01,02,03), the second is international form disease records according to the ICD-10 system.

    Primarily, the reform was carried out to avoid cases of fraud associated with sick leave payments. That's why there's honey in everything. Institutions forms are received directly through FSS branches. The sheets are marked with serial numbers, so it becomes much easier to track illegal fraud. In addition, new sheets of paper are protected with watermarks, micro-text and some other methods.

    It is best to fill out the sheet using printed media, as well as a black pen. Entries must be placed exactly within the boundaries of the cells and frames. Such accuracy is necessary so that the form can be processed by a computer - electronic reading is quite sensitive and demanding. The physician must not cross out, sign, or otherwise change the completed form.

    Sample of a completed sick leave certificate:

    If you need to change information, you should take new leaf. The employer has the right to make mistakes and make corrections to the records, but this is highly undesirable. Corrections are written on the back of the sheet, incorrect data is crossed out.

    Then you should sign and date it, recording the fact of the corrections. We also recommend that you read the article, from which you will learn about inaccuracies that FSS employees will not pay attention to.

    The form must be filled out by two people: the doctor and the employer. The doctor is responsible for completing sections 1 and 3. The employer, in turn, is for the second. It should be taken into account that the FSS carries out quality control and conducts random checks. In the future, the Fund plans to switch completely to electronic system sick leave, which will further simplify the control task.

    When registering/using sick leave, you should rely on the Tax, Labor and Administrative Code. In addition, important documents are Federal Laws N212, N125, N255. In any unclear cases, you should contact the FSS department for advice.

    On the back side of the sheet you can always find instructions for filling out, as well as a decoding of all codes.

    Registration procedure

    There are three people involved in registration: the doctor, the employer and the employee. An employee becomes ill and goes to a medical facility. The doctor must diagnose the patient's disease and health condition. Based on this, the doctor determines the duration of sick leave and enters it into the form. To do this, use the corresponding unified codes (detailed explanation below). Then he indicates the following information about the patient:

    • Date of Birth;
    • Name of the enterprise - according to the patient, no special documents are required. If the employer is individual entrepreneur, then enter the full name of the individual. employer person.

    The doctor must also indicate the name, address and registration number his medical institution. After this, the sheet should be signed and stamped. If the attending physician is engaged in private practice, then he similarly indicates his full name and register. number.

    The employee takes the form completed by the doctor to the administration at the place of work. The employer fills out information regarding payment calculations and information about his company:

    • Name of organization - 29 cells are allocated, one empty cell must be left between words;
    • Type of work (main or part-time);
    • Registration number in the Social Insurance Fund (enterprise);
    • Subordination code;
    • Employee number (identification);
    • Fear. number;
    • Payment terms;
    • Fear. employee experience;
    • Avg. earnings;
    • Full name of the head. accountant and company manager;
    • Amount of payments - indicate three amounts: from the employer, from the Fund and the final amount (due to the employee).

    In addition, the data necessary for the tax authorities is recorded. Every year, tax reports (2-NDFL) must be prepared for all employees. On sick leave, the tax code is always 2300. The benefit is not taxed, although formally it is classified as income. A 2-NDFL certificate is sometimes required for an employee to get a loan; it may be necessary in a new workplace. The employee always has the opportunity to check the correctness of payments.

    Explanation of the fields on the sick leave:

    The employee is also a participant in the registration process, but he practically does not fill out anything. All he needs to do is consult a doctor in a timely manner and obtain a certificate of incapacity for work. Then it is necessary (within compliance with the deadlines) to provide the completed form at the place of work.

    Codes

    Special digital codes are used to record information describing the nature (diagnosis, disease, cause) and duration of disability. Codes can be two-digit or three-digit (starting from zero). Using such a flexible system, all reasons for incapacity/sick leave are coded. There are 15 main causes of disability(diseases), let's figure out what the codes on the sick leave mean, what disease and diagnosis is hidden behind it, and let's start deciphering them:

    • “01” - disease, the most common case, especially during influenza epidemics;
    • "02" — domestic injury, that is, damage to the body received outside of work/workplace;
    • “03” - quarantine, indicates the need for quarantine, typical for infectious diseases, for example, tuberculosis;
    • “04” is a work-related injury, but correct name there will be an “occupational accident”;
    • “05” - the onset of disability due to pregnancy and childbirth;
    • "06" - prosthetics, which (according to medical reasons) can only be carried out in a hospital;
    • "07" - prof. disease, as well as exacerbation of prof. diseases, especially typical for industries with hazardous conditions;
    • “08” - medical procedures in hospitals and sanatoriums;
    • “09” - disability due to the need to care for a sick family member (for example, a disabled person);
    • “10” - poisoning, as well as other conditions;
    • “11” is a disease from the list of social services. significant diseases, the list was approved by Government Decree N715. These include, in particular, tuberculosis, hepatitis, HIV, diabetes, oncology;
    • “12” - the reason is the illness of a child under 7 years old, the need for additional care;
    • “13” - caring for a disabled child;
    • “14” - cancer in a child or a post-vaccination complication;
    • “15” – HIV infection in a child.

    Points “14” and “15” are noted on the form only with the consent of the insured person (employee).

    After the code “15”, three-digit designations begin (the first is “017”), they are indicated next to the above two-digit ones. They are incremental in nature, giving more detail if needed, and they start with the number “0.” There are five such designations in total:

    • “017” - indicate if the treatment took place in a special facility. sanatoriums;
    • “018” - undergoing sanatorium-resort treatment due to an industrial injury;
    • “019” – treatment in a clinic at a university/institute;
    • "020" - additional holiday for labor and finance;
    • “021” - noted if the disease/injury was caused by alcohol and drug use.

    Thus, correlating the reason with the established list, the doctor enters the reason on the form. For example, if a woman is on sick leave according to BiR and received additional leave for this reason, the form will indicate the codes “05” and “017”.

    Then, in the lines “Other” and , the code again becomes two-digit. Let's figure out what some of the codes in the "Other" section mean:

    • “31” - noted if the employee continues to be sick;
    • “32” - the employee was assigned a disability;
    • "34" - death(in this case: the reason for the end of sick leave);
    • “36” - the patient arrived (at the appointment) healthy and able to work.

    In addition to codes for causes of disability, there are so-called ICD codes ( international classification diseases). The latest version is ICD-10, the tenth edition of this classification. The doctor on sick leave also notes the disease according to the ICD system. There are 22 classes of diseases in total. They are designated from "A00" to "Z100". The ICD is already completely medical information.

    If the doctor made a mistake when filling out the codes, then he must take a new, blank form. He is not allowed to cross out, sign or make changes.

    Conclusion

    A sick leave certificate is required when registering an employee’s temporary disability. In 2011, in order to optimize document flow and reduce FSS costs, a reform was carried out. Causes and diseases are recorded using digital symbols called codes.

    Information is indicated using two designations - the first is the national designation of the cause of disability (for example, injury, disease), the second is the international designation of the disease according to the ICD-10 system, it provides more detailed medical information.