Lazolvan cough syrup for children instructions. "Lazolvan" is an effective drug for colds. In the event of an allergy, external changes in the skin may appear in the form of

Mucolytic and expectorant drug

Active substance

Release form, composition and packaging

◊ Syrup transparent or almost transparent, colorless or almost colorless, slightly viscous, with the smell of wild berries.

Excipients: benzoic acid - 8.5 mg, hyaetellose (hydroxyethylcellulose) - 10 mg, acesulfame potassium - 5 mg, liquid sorbitol (non-crystallizing) - 1.75 g, glycerol 85% - 750 mg, wild berry flavor PHL-132195 - 11 mg, flavor vanilla 201629 - 3 mg, purified water - 3.0475 g.

100 ml - amber or brown glass bottles with a child-safe plastic screw cap with thread and tamper evident (1) complete with a measuring cup - cardboard packs.
200 ml - amber or brown glass bottles with a child-safe plastic screw cap with thread and tamper evident (1) complete with a measuring cup - cardboard packs.

pharmachologic effect

Studies have shown that ambroxol increases secretion in the respiratory tract. Enhances the production of pulmonary surfactant and stimulates ciliary activity. These effects lead to increased mucus flow and transport (mucociliary clearance). Increasing mucociliary clearance improves sputum discharge and relieves cough.

In patients with COPD, long-term therapy with the drug (for at least 2 months) led to a significant reduction in the number of exacerbations. There was a significant decrease in the duration of exacerbations and the number of days of antibiotic therapy.

Pharmacokinetics

Suction and distribution

For all dosage forms ambroxol immediate release characterized by rapid and almost complete absorption with a linear dose dependence in the therapeutic concentration range. C max at orally is achieved after 1-2.5 hours. In the therapeutic concentration range, binding to plasma proteins is approximately 90%.

V d is 552 l. In the therapeutic concentration range, binding to plasma proteins is approximately 90%.

The transition of ambroxol from blood to tissues during oral administration happens quickly. The most high concentrations active component of the drug are observed in the lungs.

Metabolism and excretion

Approximately 30% dose taken undergoes a “first pass” effect through the liver. Studies in human liver microsomes have shown that CYP3A4 is the predominant isoform responsible for the metabolism of ambroxol to dibromoantranilic acid. The remainder of ambroxol is metabolized in the liver, mainly by glucuronidation and by partial breakdown to dibromoantranilic acid (approximately 10% of the administered dose), and small quantity additional metabolites.

The terminal half-life of ambroxol is 10 hours. The total clearance is within 660 ml/min, at renal clearance accounts for approximately 8% of the total clearance. Using the radioactive tracer injection method, it was estimated that after taking a single dose of the drug, about 83% of the dose taken is excreted in the urine over the next 5 days.

Pharmacokinetics special groups patients

No clinically significant effect of age and gender on the pharmacokinetics of ambroxol was found, so there is no basis for selecting the dose based on these characteristics.

Indications

Acute and chronic diseases respiratory tract accompanied by the release of viscous sputum:

- acute and chronic bronchitis;

- pneumonia;

Dosage

The drug is administered orally, regardless of food intake.

Adults and children over 12 years old prescribed 10 ml 3 times/day; children aged 6 to 12 years- 5 ml 2-3 times/day; children aged 2 to 6 years- 2.5 ml 3 times/day; children under 2 years old- 2.5 ml 2 times/day.

If symptoms of the disease persist within 4-5 days from the start of using the drug, you should consult a doctor.

Side effects

From the outside digestive system: often (1-10%) - nausea, decreased sensitivity in the oral cavity and pharynx; uncommon (0.1-1%) - dyspepsia, vomiting, diarrhea, abdominal pain, dry mouth; rarely (0.01-0.1%) - dry throat.

From the outside nervous system: often (1-10%) - dysgeusia (impaired sense of taste).

Allergic reactions: rarely (0.01-0.1%) - rash, urticaria, anaphylactic reactions (including anaphylactic shock)*, angioedema*, itching*, hypersensitivity*.

* these adverse reactions were observed with widespread use drug; with 95% probability data frequency adverse reactions- infrequently (0.1-1%), but possibly lower; the exact frequency is difficult to estimate, because they were not noted in clinical studies.

Overdose

Specific symptoms of overdose in humans have not been described.

There have been reports of accidental overdose and/or medical error resulting in symptoms famous side effects drug Lazolvan: nausea, dyspepsia, diarrhea, vomiting, abdominal pain.

Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug, symptomatic therapy.

Drug interactions

No clinically significant adverse interactions with other drugs have been reported.

Ambroxol increases the penetration of amoxicillin and erythromycin into the bronchial secretions.

special instructions

Lazolvan syrup should not be used in combination with antitussives that impede the removal of sputum.

There are isolated reports of severe skin lesions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, coinciding with the use of expectorants such as ambroxol hydrochloride. In most cases, they are explained by the severity of the underlying disease and/or concomitant therapy. Patients with Stevens-Johnson syndrome or toxic epidermal necrolysis may present in the early phase with fever, body pain, rhinitis, cough, etc. At symptomatic treatment possible erroneous assignment cold remedies. If new lesions of the skin and mucous membranes develop, the patient should stop treatment with ambroxol and immediately seek medical help.

Lazolvan syrup (15 mg/5 ml) contains 10.5 g of sorbitol based on the maximum recommended daily dose (30 ml). Patients with rare hereditary intolerance fructose you should not take this drug.

If renal function is impaired, Lazolvan should be used only as prescribed by a doctor.

Impact on ability to manage vehicles and mechanisms

There were no cases of the drug affecting the ability to drive vehicles and machinery. Studies on the effect of the drug on the ability to drive vehicles and engage in other potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions were not carried out.

Pregnancy and lactation

Ambroxol penetrates the placental barrier.

Preclinical studies have not revealed direct or indirect adverse effects on pregnancy, embryonic/fetal, postnatal development and labor.

Extensive clinical experience There was no evidence of ambroxol use after 28 weeks of pregnancy negative influence drug for the fetus. However, normal precautions must be taken when using the drug during pregnancy. It is especially not recommended to take Lazolvan in the first trimester of pregnancy. In II and III trimesters During pregnancy, the use of the drug is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 3 years.

- If only the child gets well soon.

Treatment children's cough, especially if it is intrusive, dry and unproductive, often causes difficulty for young mothers. How to help your baby?

Commonly used to treat dry cough drugs that dilute viscous sputum and help quickly remove it from the bronchi. One of the popular remedies for combating dry cough is Lazolvan syrup for children.

Both mothers and children count on help.

It easily copes with this type of cough and a short time"turns" it into wet wet. Our review will help you understand the intricacies of application medicinal product Lazolvan will be useful to all young parents.

Operating principle

Cough syrup Lazolvan belongs to the group of expectorants and successfully fights phlegm. Basics active substance, part of Lazolvan - Ambroxol is one of the most popular mucolytics, widely used all over the world. Once in the child’s body, the drug begins to act within an hour and continues for 6-12 hours.

Ambroxol is the main active ingredient.

The action occurs according to the following scheme:

• Once in the body, Lazolvan “starts” the process of sputum secretion, thereby quickly turns a dry cough into a wet one;
• dilutes sputum and helps its successful separation;
• makes it much easier hard breathing, making it softer and calmer.

Treatment of cough with Lazolvan: pros and cons

The syrup can be prescribed even to newborns. He is absolutely safe and highly effective in combating various diseases respiratory tract, accompanied by heavy sputum production. Doctors prescribe treatment with Lazolvan for diseases such as:

• acute, chronic and obstructive bronchitis;
• pneumonia;
• bronchial asthma.

In addition, Lazolvan syrup can be used for respiratory diseases that occur against the background of acute respiratory infections and other viral diseases accompanied by a prolonged dry cough.

As for contraindications, the syrup is not recommended for children prone to allergic dermatitis and those suffering from fructose intolerance. Also during treatment with Lazolvan Do not take cough suppressants at the same time for example codeine.

When, how much and how? - instructions for use and dosage

To enhance the effect of the drug, you need to take it before meals or right during meals. You should not ignore the abundant warm drink during treatment - this will significantly speed up the healing process.

The dosage of syrup is selected individually depends on the patient's age:

• children from birth to two years are usually prescribed half a teaspoon of syrup twice a day;
• children aged two to six - half a teaspoon three times a day;
• After six years, children take a teaspoon three times a day.

I am 4 years old and I drink half a teaspoon three times a day.
Well, or a little more... because it’s delicious!

More information about the methods of use and doses of Lazolvan can be found in the instructions for use of this drug. You can download the instructions Here.

Sometimes parents confuse Lazolvan, produced in syrup form, with the inhalation solution of the same name. This different medicines. The solution, although it can be taken orally, has an unpleasant bitter taste. The syrup has a pronounced fruit or berry taste that children like.

There are raspberries on the package.

What else can be used for a cough?

The range of prices in pharmacies for Lazolvan cough syrup is from 190 to 290 rubles.

It may happen that the drug is not available in the pharmacy, or perhaps it is available, but the cost is high, and it also happens that the baby is allergic to its components. In all these cases useful to know about existing analogues and how to choose them correctly.

So, what can replace Lazolvan? Its active substance is ambroxol, and, based on this, a list of drugs with similar effects can be compiled.

• The most inexpensive and most unknown analogue of Lazolvan is. It costs between 50-80 rubles. Ambroxol has the same effect and can also be used to relieve dry cough in children from birth.
• - also made on the basis of ambroxol. It has a pleasant raspberry scent and copes with even the most difficult conditions without any problems. severe cough. The cost of Ambrobene is approximately 130-150 rubles.
• Syrup Ambrohexal also has similar composition. The drug dilutes sputum well and helps its successful removal from the body. The syrup costs about 120-150 rubles.

Liquefies and removes.
Does it effectively.

All kinds colds V childhood happen quite often. One of the most unpleasant cold symptoms- This is a painful cough that does not go away for a long time.

It was to relieve cough that the pharmaceutical concern Boehringer Ingelheim developed the expectorant mucolytic drug Lazolvan.

You can purchase the drug in several dosage forms: solution for inhalation, ampoules for injection, tablets or syrup. For children, sweet syrup will be the most convenient form of release.

• Syrup It is a practically colorless and transparent viscous liquid with a fruit and berry odor. The medicine is poured into glass bottles of 100 or 200 ml and packaged in cardboard boxes.
• Inhalation solution also available in dark glass bottles of 2 ml. The solution itself is transparent and colorless, without a distinct odor.

Compound

The active ingredient of the drug is ambroxol hydrochloride. Each teaspoon of sweet liquid (5 ml) will contain 15 mg active substance. Additional Ingredients: Sorbitol solution, hydroxyethylcellulose, glycerin, benzoic and tartaric acids, propylene glycol, flavorings and purified water.

Lazolvan in the form of an inhalation solution for children contains the following dosage of the active substance: 15 mg in each bottle. Auxiliary ingredients in the solution are lemon acid, Sodium DHF Dihydrate, Water, Sodium Chloride.

Operating principle

The medicine is a mucolytic, that is, sputum-thinning agent. The active ingredient ambroxol, when ingested, increases the secretion of the glands of the respiratory tract and stimulates their activity.

Due to the action of the drug, sputum thins, is easier to separate from the walls of the bronchi, and is eliminated more quickly when coughing. A dry, debilitating cough gives way to a productive expectorant cough, and later the attacks become less frequent and disappear completely.

The action of the drug is based on such pharmacological effects ambroxol:

• pulmonary epithelial cells begin to more actively secrete enzymes that dilute sputum;
• the activity of epithelial cilia increases, so sputum is pushed out of the lungs faster;
• the synthesis of a special substance that does not allow the alveoli to fall off - pulmonary surfactant - increases;
• increases the amount of mucus during a dry cough, transforming it into a “wet” one.

After oral administration, ambroxol begins to act within half an hour, concentrating as much as possible in lung tissue. Processed by the liver and excreted in the urine.

Indications: when prescribed to children

Lazolvan – reliable means in relieving symptoms of respiratory diseases. The drug is prescribed for acute and chronic bronchopulmonary diseases, which are associated with impaired bronchial secretion and difficulty in sputum discharge.
The instructions recommend use in the following cases:

• pneumonia, bronchitis and other inflammatory infectious diseases respiratory organs;
• chronic obstructive pulmonary diseases: bronchopulmonary dysplasia, asthma;
• diseases of the respiratory organs, which are accompanied by impaired discharge and viscosity of sputum.

At what age is it allowed to take

The instructions allow the use of Lazolvan even for pregnant women after the 28th week. However, the drug is not recommended during breastfeeding, since ambroxol passes into breast milk.

Moreover, the medicine is approved in pediatric practice and is used to treat the smallest: newborns and even premature babies. Up to two years, the daily dose is 1 teaspoon. This amount is divided into two doses: half a teaspoon in each dose.

Contraindications and side effects

The instructions emphasize that in case of impaired renal function, use is permissible only after consultation with a doctor.
According to the instructions, reception is prohibited and in this case hereditary disease, such as fructose intolerance, since the product contains sorbitol.

But there is no sugar or alcohol in the composition, so patients diabetes mellitus the remedy is allowed.

Among the possible side effects, the instructions mention the following:

• from the outside immune system– anaphylactic shock, rashes, urticaria, dermatitis and other allergic reactions;
• taste disorder;
• from the gastrointestinal tract and respiratory system: nausea, vomiting, abdominal pain and diarrhea, dry mouth and throat.

If any side effects occur, treatment with Lazolvan should be stopped and medical help should be sought.

Lazolvan for children: instructions for use for children

• up to 2 years: 2.5 ml or half a teaspoon twice a day;
• from 2 to 6 years: the same half teaspoon is given three times a day;
• from 6 to 12 years old you need to take 1 spoon - 5 ml of syrup at a time;
• for the treatment of adults and adolescents, starting from 12 years old, it is recommended to drink 10 ml, that is, 2 spoons three times a day.

Important! If the symptoms of the disease, instead of decreasing or disappearing, on the contrary, intensify, it is necessary to suspend treatment and consult a doctor.

Lazolvan inhalation instructions for use for children recommend using 1-3 times a day, depending on the age of the child and the severity of the disease. Up to two years, the frequency of procedures is one or two per day, the amount of solution is 7 ml. From 2 to 5 – use 15 ml of solution. For adolescents and adults, add 20 ml of Lazolvan to the inhaler.

Overdose

The manufacturer states in the instructions for use that systemic cases of overdose are unknown. If an overdose does occur, then symptomatic treatment is used.

The instructions warn that if the daily dose is systematically exceeded, nausea, heartburn, gastralgia and vomiting may occur.

Interaction with other drugs

• Food intake does not affect the bioavailability of ambroxol hydrochloride.
• There is no data on clinically undesirable interactions with other drugs.
• It is known that after taking ambroxol, the concentration of antibiotics in bronchopulmonary secretions and sputum increases. This applies to substances such as amoxicillin, erythromycin and cefuroxime.
• It is strictly forbidden to take Lazolvan and cough suppressants at the same time, as this leads to the accumulation of mucus in the bronchi.

Analogs

In addition to Lazolvan, other cough syrups for children are also produced based on ambroxol. One of the most famous analogues of this type is - baby syrup Ambrobene, as well as products with a more budgetary cost: Abrol and Ambroxol.

Mucolytic children's cough remedies, but with a different active ingredient, include:

• —Bromhexine syrup for children—;

• Acysteine ​​granules for the preparation of oral solution;
• —children's ACC—in powder for oral use;

• Fluditec, approved for use from two years of age.

Lazolvan syrup for children: reviews

• Marina believes that due to widespread advertising, the price of Lazolvan is overpriced, and cheaper analogues based on ambroxol can be found. Marina tried to treat budget funds The eldest son has a cough, but his one and a half year old son still buys Lazolvan. For a woman, the main argument is that it was Lazolvan that the pediatrician recommended even from the first days of life. First youngest son She had to be treated since she was 4 months old - and the syrup worked great. Therefore, Marina definitely recommends Lazolvan for dry coughs. small child. And for adults, in her opinion, you can get by with cheaper analogues. However, in any case, treatment with a mucolytic agent can only be started after consulting a doctor.
• Katya notes pleasant taste medications and a convenient measuring cap. The use of the product not only improved sputum discharge, but also relieved sore throat. Of course, if the cough is severe, then treatment should be comprehensive. When Katya, a 4-year-old child, fell ill, the syrup was taken along with medicines for the nose, throat and tonic. We used Lazolvan three times a day, which allowed us to somewhat mitigate cough attacks. However, only the addition of antibiotics to therapy helped the baby to recover completely.
• Anya considers Lazolvan one of the best mucolytics. When her daughter caught a cold, the most painful symptom of the disease was debilitating nonproductive cough. After unsuccessful treatment, the pediatrician prescribed Lazolvan orally and for inhalation. Anya did inhalations 1-2 times a day, drinking syrup during meals. Relief came almost immediately: night sleep became calmer and more even. And with continued treatment, the cough was finally defeated.
• Christina warns against exceeding the dose: since the syrup seems to be a harmless sweetness and not a medicine, Christina measured the product “by eye.” For her son at the age of 1.5 years, the prescribed single dose was 2.5 ml, but the woman felt that a slightly larger dosage would contribute to recovery. However, this negligence led to too intense production of sputum: the baby began to wheeze, gurgling was heard when breathing. After consultation with the doctor, the dosage was adjusted - and the treatment was completed successfully.
• Sveta first experienced the effects of syrup when she and her three-month-old baby were admitted to the hospital. At first, the health disorder looked like difficulty in nasal breathing, and then a cough and bronchitis developed. Now the syrup is always at home medicine cabinet, because its shelf life is quite long, and it can be used to treat both children and adults. After using the product, sputum discharge begins on days 1-2 of use, and by the 5th day the cough disappears.

Video about inhalations

The use of Lazolvan in the form of a solution for children is described in the instructions for use. And below you can watch a video in which a medical worker from the physiotherapy department explains in detail general rules administering inhalations to a child.

Lazolvan – good remedy, if used as prescribed by a doctor and as part of complex therapy. After all, it is unlikely that you will be cured with just one dose of syrup. Share your experience of using Lazolvan. Would you recommend this drug to your friends? Write your opinion in the comments.

Among all the problems that children themselves have of different ages, cough is one of the most common. In this case, you can treat yourself with the most different drugs. Now we'll talk about such a medication as “Lazolvan”: instructions for use. Syrup for children - how to use it correctly and what you need to know about this medicine.

Basic information about Lazolvan syrup

First of all, I would like to point out that this medicine designed to have an expectorant effect. This is a mucolytic drug in which the main active ingredient is ambroxol hydrochloride.

Its use leads to improved secretion and removal of mucus, which reduces the cough effect.

The maximum concentration of the drug in the body is reached no earlier than half an hour after administration.

The syrup works actively for 7-12 hours, after which it is successfully excreted mainly through the kidneys (90%).

Indications for use of the drug "Lazolvan"

Let us next consider the drug “Lazolvan”: instructions for use. The doctor may prescribe syrup for children for chronic and acute diseases of the baby’s respiratory tract, when viscous sputum is produced. This can occur with the following diseases:

1. Pneumonia.
2. Obstructive pulmonary disease (chronic) – COPD.
3. Bronchitis, both chronic and acute.
4. Bronchial asthma, which is accompanied by difficulty in sputum discharge.

It is also important to note that this drug is used to get rid of distress syndrome in premature babies, including newborns.

The drug "Lazolvan" (syrup for children): instructions for use

The drug "Lazolvan" is available in a variety of pharmaceutical forms. So, this is not only a syrup, but also a solution for an inhaler, as well as lozenges for resorption. Doctors most often prescribe syrup for children. After all, babies can choke on pills, and for inhalations they need a nebulizer - a special inhaler with which the baby can receive medicine.

It is important to remember that any medicine should be prescribed exclusively by a doctor in accordance with the disease and symptoms observed in little patient.

"Lazolvan" (syrup): dosage for children

Be sure to also talk about how to give correctly this drug children. So, it is important to note that the doctor can prescribe it even to the youngest patients. "Lazolvan" has been used since birth. Dosage:

1. Children under 2 years of age are given 7.5 mg twice a day.
2. For children 2-5 years of age, the same dosage is given not twice, but three times a day.
3. Children aged 5-12 years are prescribed 2-3 one-time appointment 15 mg per day.

How to give Lazolvan syrup to older children? The dosage here will be the same as for adults. That is, in the first three days the dose will be 10 ml a couple of times a day, then 5-6 ml three times or 10 ml twice for 24 hours.

Contraindications to the use of the drug "Lazolvan"

Let us next consider the drug “Lazolvan”: instructions for use. Doctors generally prescribe syrup for children without fear, because no cases of overdose have yet been recorded in medicine. If this happens, a small patient may experience nausea, vomiting, and diarrhea. Abdominal pain may also occur.

There are two contraindications for use:

• Personal intolerance to the components of the drug.
• Fructose intolerance, including hereditary (the drug has a strawberry flavor).

Side effects from the use of the drug "Lazolvan"

What else needs to be said about the drug “Lazolvan” (syrup for children)? The instructions for use state that certain side effects from taking medication (which, by the way, happens very, very rarely). So, these are mainly allergies in the form of skin rashes (