Furazolidone as an effective antimicrobial agent - instructions. Indications for use. Furazolidone tablets: price, reviews


Analogs of the drug furazolidone are presented, in accordance with medical terminology, called “synonyms” - drugs that are interchangeable in their effect on the body, containing one or more identical active ingredients. When selecting synonyms, consider not only their cost, but also the country of production and the reputation of the manufacturer.

Description of the drug

Furazolidone- Antimicrobial agent, nitrofuran derivative. Active against gram-negative bacteria (including Shigella spp., Salmonella spp.), some gram-positive bacteria, as well as Trichomonas vaginalis, Giardia lamblia.

List of analogues

Note! The list contains synonyms of Furazolidone having similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from of Eastern Europe: KRKA, Gedeon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.


Reviews

Below are the results of surveys of site visitors about the drug furazolidone. They reflect the personal feelings of the respondents and cannot be used as official recommendation when treated with this drug. We strongly recommend that you contact a qualified medical specialist to select a personal course of treatment.

Visitor survey results

Two visitors reported effectiveness

Participants%
Effectively2 100.0%

Your answer about efficiency »

Visitor Report of Side Effects

Your answer about side effects »

One visitor reported an estimate of the cost

Participants%
Not expensive1 100.0%

Your answer about the cost estimate »

Two visitors reported frequency of intake per day

How often should you take Furazolidone?
Most respondents most often take this drug 4 times a day. The report shows how often other survey participants take this drug.
Your answer about dosage »

Three visitors reported an expiration date

How long does it take to take Furazolidone to feel an improvement in the patient’s condition?
Survey participants in most cases felt an improvement in their condition after 1 month. But this may not correspond to the period after which you will begin to improve. Check with your doctor for how long you need to take this medicine. The table below shows the results of the survey on the initiation of effective action.
Participants%
1 month1 33.3%
5 days1 33.3%
1 day1 33.3%

Your answer about the start date »

Visitor report on reception time

Information has not yet been provided
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Eighteen visitors reported the patient's age


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Visitor reviews


There are no reviews

Official instructions for use

There are contraindications! Read the instructions before use

Instructions
on medical use of the drug

Furazolidone

Registration number LSR-004228/09-280509
Tradename: Furazolidone

International nonproprietary name:

Furazolidone

Dosage form:

pills

Compound:


1 tablet contains:
Active substance - Furazolidone - 0.05 g
Excipients - potato starch - 0.02 g
  • calcium stearate (calcium stearate) - 0.001 g
  • sugar (sucrose) - 0.01 g
  • Tween-80 (polysorbate) -0.0002 g
  • lactose (milk sugar) - 0.0188 g
    Description:
    Tablets are yellow or greenish-yellow, flat-cylindrical with a bevel.

    Pharmacotherapeutic group:

    Antimicrobial and antiprotozoal agent.
    ATX code: G01AX06
    Pharmacodnnamnka
    Antimicrobial agent, derivative of nitrofurans. Active against gram-positive and gram-negative microbes, Trichomonas spp., Ciardia lamblia. The most sensitive to furazolidone are Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp.. Salmonella typhi, Salmonella paratyphi. Weak effect on pathogens of purulent and anaerobic infection. Microbial resistance develops slowly. Blocks monoamine oxidase.
    Nitrofurans disrupt processes cellular respiration microorganisms, suppress the tricarboxylic acid cycle (Krebs cycle), and also inhibit the biosynthesis of nucleic acids of microorganisms, resulting in the destruction of their membrane or cytoplasmic membrane. As a result of the action of nitrofurans, microorganisms release fewer toxins, and therefore improvement general condition patient is possible even before pronounced suppression of microflora growth. Unlike many other antimicrobial drugs, they not only do not inhibit, but even activate immune system body (increase complement titer and the ability of leukocytes to phagocytose microorganisms).

    Pharmacokinetics

    Well absorbed when administered orally. Against the background of inflammation meninges concentrations are created in the cerebrospinal fluid equal to those in the plasma. It is quickly and intensively metabolized mainly in the liver with the formation of a pharmacologically inactive metabolite (amino derivative). Excreted mainly by the kidneys (65%), small quantities found in feces, where therapeutic concentrations are achieved against intestinal pathogens
    Indications for use
    Dysentery, paratyphoid fever, giardiasis, food toxic infections.

    Contraindications

    Pregnancy, lactation. Increased individual sensitivity to the nitrofuran group. Terminal stage chronic renal failure, glucose-6-dehydrogenase deficiency, childhood up to 3 years (for this dosage form).
    Carefully
    Chronic renal failure, glucose-6-phosphate dehydrogenase deficiency, liver disease and nervous system.

    Directions for use and doses

    Inside, after eating. For dysentery, paratyphoid fever and food poisoning - 100-150 mg 4 times a day (but not more than 800 mg), for 5-10 days.
    For giardiasis: adults - 100 mg 4 times a day, children - 10 mg/kg/day, distributed daily dose for 3-4 doses. The highest single dose for adults is 200 mg; daily - 800 mg.

    Side effects

    Decreased appetite, up to anorexia; nausea, vomiting; allergic reactions ( skin rash, hyperemia and itching of the skin, angioedema). At long-term use- neuritis.
    Overdose (intoxication) of the drug
    Symptoms: acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis). Treatment: drug withdrawal, administration large quantity liquids, symptomatic therapy, antihistamines, B vitamins.

    Interaction with other drugs

    Furazolidone in combination with ethanol can lead to the development of disulfiram-like reactions, and therefore their simultaneous use is not recommended.
    Antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, phenylephrine, tyramine may cause sharp increase blood pressure.

    special instructions

    Increases inhibition of hematopoiesis against the background of chloramphenicol and ristomycin. Increases sensitivity to the action of ethanol. Medicines that alkalize urine reduce the effect, while those that acidify urine increase it.
    Aminoglycosides and tetracycline enhance antimicrobial properties.
    During treatment, precautions must be taken, as when using monoamine oxidase inhibitors, namely: exclusion from the diet of foods containing tyramine: cheese, cream, beans, pickled herring, strong coffee. To prevent neuritis with long-term use, it must be combined with B vitamins.

    Release form

    Pills. 50 mg.
    10 tablets in cell-free packaging. 50 tablets per orange glass jar.
    800 contour cellless packages or 240 cans with equal amount instructions for use are placed in a cardboard box (for hospitals).

    Storage conditions

    List B.
    In a dry place, protected from light. Keep out of the reach of children.

    Best before date

    3 years.
    Do not use after the expiration date.

    Vacation conditions

    Over the counter.

    Manufacturer

    OJSC "Irbit Chemical and Pharmaceutical Plant" 623800, Sverdlovsk region, Irbit, st. Kirova, 172

    The information on the page was verified by physician-therapist E.I. Vasilyeva.

  • Furazolidone for the prevention of infection in trauma

    I took furazolidone to prevent a fungal infection when I injured my leg in nature. I had to go to the emergency room, where they stitched up the wound and prescribed antibacterial agent. I took 1 tablet of Furazolidone for 4 days in a row, during which time the stitches healed normally and there was no suppuration. When examined by a doctor, there were also no signs of infection... I took furazolidone to prevent a fungal infection when I injured my leg in nature. I had to go to the emergency room, where they stitched up the wound and prescribed an antibacterial agent. I took 1 tablet of Furazolidone for 4 days in a row, during which time the stitches healed normally and there was no suppuration. When examined by a doctor, no signs of infection were found either.

    I tried taking it for cystitis, but it didn’t help, apparently the bacteria had become completely insensitive to it, in the end I had to take another monural, fortunately, it’s only taken once. And now it probably only makes sense to treat intestinal disorders with furazolidone.

    This is an excellent drug!!! Saved me from cystitis more than once. And my little daughter from diarrhea. True, I always take a dose 2 times less than the doctor prescribes. In general, I try to take medications as little as possible and only when absolutely necessary.

    Everything is very individual, after furazolidone I was barely saved due to Quincke’s edema. It’s scary to remember... I won’t recommend it to anyone... There may have been an overdose, although, judging by the instructions for using the drug, it was not significant.

    Furazolidone helped me with cystitis. But I didn’t take 2 tablets as stated, but 1 (I’m still afraid of antibiotics). It helped right away on the third pill. As for diarrhea, for me it’s longer cheap remedy- Levomycetin.

    We were prescribed Furazolidone in the hospital when we were hospitalized with cheese poisoning. The child was put on a drip and I believe that it was Furazolidone that helped us, since after starting its use the child began to recover. We took it for a week and after a week of treatment we were discharged from the hospital. In addition, the drug did not have any effect... We were prescribed Furazolidone in the hospital when we were hospitalized with cheese poisoning. The child was put on a drip and I believe that it was Furazolidone that helped us, since after starting its use the child began to recover. We took it for a week and after a week of treatment we were discharged from the hospital. In addition, the drug did not have any effect side effects. I think it's all individual. We were lucky.

    I don’t know, but Furazolidone helped me. More precisely, he helped cure a child of diarrhea. A couple of months ago, I don’t understand where, we picked up some kind of infection, and my daughter carried it for a week. We tried gentle drugs, such as enterofuril, enterosgel, smecta. Nothing helped at all. The pediatrician listened to me and told me to take Furazolidone with Linex. The diarrhea stopped after two days. Here... I don’t know, but Furazolidone helped me. More precisely, he helped cure a child of diarrhea. A couple of months ago, I don’t understand where, we picked up some kind of infection, and my daughter carried it for a week. We tried gentle drugs, such as enterofuril, enterosgel, smecta. Nothing helped at all. The pediatrician listened to me and told me to take Furazolidone with Linex.
    The diarrhea stopped after two days. Like this. Can Furazolidone old way treat infections, but it is effective. I don’t see anything wrong with being treated with Furazolidone. Moreover, it was prescribed to us by a doctor and a very smart doctor with many years of experience.

    I don’t know, but for me, Furazolidone is already an old way to treat stomach infections. Yes, I understand, it is not expensive, but now there are many others safe drugs to treat infection. Although, it depends on what kind of infection. My mother often suffers from diarrhea. She either ate something wrong or drank something. And than... I don’t know, but for me, Furazolidone is already an old way to treat stomach infections. Yes, I understand, it is not expensive, but now there are many other safe drugs to treat the infection. Although, it depends on what kind of infection.
    My mother often suffers from diarrhea. She either ate something wrong or drank something. And then he suffers. So she’ll buy herself this Furazolidone and let’s drink it. I say that this is an antibiotic, why plant your liver. In general, I scolded her and bought her Atoxil and Enterosgel. for removing toxins - this is it.
    I myself, personally, would not recommend Furazolidone to anyone.

    I took furazolidone for food poisoning. Maybe, of course food poisoning, to put it very loudly, I just had diarrhea. And suspicion fell on the ice cream. There was nothing except diarrhea, but other remedies did not help. I took all sorts of drugs for 3 days, but to no avail. I went to the doctor, explained the whole situation, and he prescribed Furazolidone. This is antibacterial... I took furazolidone for food poisoning. It could, of course, be food poisoning, that’s a strong word, it was just diarrhea. And suspicion fell on the ice cream. There was nothing except diarrhea, but other remedies did not help. I took all sorts of drugs for 3 days, but to no avail. I went to the doctor, explained the whole situation, and he prescribed Furazolidone. It is an antibacterial and bacteriostatic agent. The first day I took 2 times 4 tablets, it got better and the next day about 2 times 2 tablets. It immediately became easier. The drug is generally universal. I know that it helps very well with inflammation genitourinary organs, for example, with cystitis.

    pharmachologic effect

    Antimicrobial agent, nitrofuran derivative. Active against gram-negative bacteria (including Shigella spp., Salmonella spp.), some gram-positive bacteria, as well as Trichomonas vaginalis, Giardia lamblia.

    Pharmacokinetics

    At oral administration Furazolidone is poorly absorbed and inactivated in the intestine. Only about 5% of the drug is excreted from the body in the urine unchanged or in the form of metabolites, causing the urine to turn brown.

    Indications

    Dysentery, paratyphoid, food poisoning, giardiasis, trichomonas urethritis.

    Dosage regimen

    For dysentery, paratyphoid fever, food toxic infections in adults, use 50-150 mg 4 times a day for 5-10 days. In children, doses are reduced according to age.

    For giardiasis in adults - 100 mg 4 times a day; children - 10 mg/kg/day in 3-4 doses.

    For trichomonas urethritis - 100 mg 4 times a day for 3 days. Maximum doses for adults: single dose - 200 mg, daily dose - 800 mg.

    Side effect

    Maybe: nausea, vomiting, loss of appetite, allergic reactions in the form of skin rash.

    Contraindications for use

    Hypersensitivity to furazolidone.

    Use during pregnancy and breastfeeding

    Contraindicated during pregnancy and lactation.

    Use in children

    Use with caution in children under 1 month of age.

    Overdose

    Symptoms: acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis).

    Treatment: drug withdrawal, taking large amounts of fluid, symptomatic therapy, antihistamines, B vitamins.

    Drug interactions

    Agents that alkalize urine reduce the effect of furazolidone, while acidifying agents increase it.

    The simultaneous use of aminoglycosides and tetracyclines enhances the antimicrobial properties.

    Furazolidone increases the inhibition of hematopoiesis against the background of chloramphenicol and ristomycin.

    Conditions for dispensing from pharmacies

    On prescription.

    Storage conditions and periods

    In a dry place, protected from light, out of reach of children, at a temperature of +5 to + 30°C. Shelf life - 3 years.

    Use for liver dysfunction

    Use with caution in patients with liver disease.

    Use for renal impairment

    Use with caution in patients with severe renal impairment.

    special instructions

    Use with caution in patients with severe renal impairment, glucose-6-phosphate dehydrogenase deficiency, and in children under 1 month of age.

    Furazolidone is a MAO inhibitor and appropriate precautions should be taken when using it.

    Furazolidone has the ability to sensitize the body to the effects of ethanol and can be used to treat alcoholism.

    Very often patients are confused antibacterial drugs and antibiotics. However, this is completely various medications. Of course, they are both designed to fight harmful microorganisms. But the first remedy is safer for human health. Therefore, whenever possible, patients are prescribed antibacterial drugs.

    One of the brightest representatives of such drugs is Furazolidone. Instructions for use, price, reviews, analogues, contraindications and indications of the mentioned product will be described below.

    Description, packaging, composition and form

    Where and in what form can you buy a medicine such as Furazolidone? Consumer reviews quite often contain information about appearance this medicine. According to them, this product can be purchased in the form of yellow or white round and flat-cylindrical tablets with a chamfer. They are sold in almost all pharmacies.

    The instructions say that the active ingredient of the product in question is furazolidone. It also contains additional substances, including lactose.

    In what packaging can you buy Furazolidone tablets? Instructions for use (we will look at reviews of the medicine below) of the drug are contained in a cardboard box, where the medication itself is located in contour cells. It can also be purchased in paper packages.

    Operating principle

    What are Furazolidone tablets? Instructions, reviews experienced specialists indicate that it is very effective

    The effect of the drug in question directly depends on the dosage taken. When using a small amount of furazolidone, it has a bacteriostatic effect. If the dosage is increased, the bactericidal activity of the drug is noted.

    It should also be said that this medication can have an immunostimulating effect.

    Principle antimicrobial action This medicine lies in the ability of the nitro groups of furazolidone under the influence of bacterial enzymes to be reduced to the amino group. The elements formed as a result of this process have a toxic effect. They disrupt the integrity and structure of the cell membrane, and also block the biochemical processes occurring in bacteria.

    After using Furazolidone, inhibition of tricarboxylic acids and irreversible blockade of NADH is observed. As a result, the respiration of microbial cells and the functioning of the cytoplasmic membrane are disrupted. After this, the death of bacteria occurs.

    Properties of the drug

    Due to the ability to form combined compounds with nucleic acids, furazolidone disrupts protein synthesis in bacterial cells, as a result of which the process of their reproduction and growth is inhibited.

    The immunostimulating property of the drug in question is due to its ability to increase phagocytic activity and leukocyte complement titer. Furazolidone also reduces the production of toxins by bacteria, resulting in an improved overall clinical picture.

    Features of the drug

    Experts have found that Furazolidone, the reviews of which are more positive character, is able to inhibit monoamine oxidase. This ultimately leads to mild agitation in the patient.

    Also, the drug in question increases a person’s sensitivity to alcohol, which can cause nausea and vomiting if consumed simultaneously medicine and alcohol.

    This medication is highly effective in treating infectious diseases, which were caused by microbes sensitive to the effects of furazolidone.

    It should be especially noted that this drug works well against Candida fungi. But before using it to treat such a disease, sensitivity tests should be performed.

    It should also be said that pathogens of purulent and

    Indications for taking tablets

    Is the drug "Furazolidone" effective for cystitis? Consumer reviews report that the medication works very well for this disease. After all, it is intended for the treatment of infectious and inflammatory diseases genitourinary system, skin and gastrointestinal tract.

    According to the instructions, the drug in question is often prescribed:

    • with giardiasis;
    • typhoid and paratyphoid fever;
    • bacillary dysentery;
    • trichomonas infection;
    • therocolite;
    • diarrhea caused by infections, including food poisoning;
    • urethritis and cystitis;
    • wounds on skin and infected burns.

    Contraindications

    Now you know what a medicine such as Furazolidone can be used for. Instructions for use, price, reviews, analogues and contraindications of this medicine are of interest to all potential buyers.

    Doctors say that this drug should not be prescribed:

    • with chronic renal failure;
    • hypersensitivity to the drug;
    • glucose-6-phosphate dehydrogenase and lactase deficiency;
    • up to one month of age.

    Only a doctor should decide whether pregnant women should take the drug.

    The medication in question is prescribed with great caution to people with diseases of the liver and nervous system.

    The drug "Furazolidone": instructions for use

    Price and reviews of these tablets will be presented at the end of the article.

    Accept this drug should only be inside. It is advisable not to chew or crush the tablets, but to swallow them whole with one glass of water.

    According to the instructions for the treatment of paratyphoid fever, dysentery and foodborne diseases Furazolidone is prescribed four times a day, 100-150 mg. Take the drug for 8-10 days.

    For colpitis, it is recommended to use this medication for three days, 100 mg four times a day. Also, 5 g of powder is injected into the vagina once a day, which consists of a mixture of furazolidone and lactose (milk sugar) in a ratio of 1:400. Can be administered into the rectum rectal suppositories with Furazolidone.

    If the patient has been diagnosed, the tablets should be taken 100 mg four times a day for three days.

    How else can you use the drug "Furazolidone"? Consumer reviews often contain information that this drug is very effective in treating giardiasis.

    For adult patients it is usually prescribed four times a day at a dosage of 100 mg, and for children - 10 mg per 1 kg of body weight per day. The resulting amount of medication is distributed into three doses.

    It should also be noted that the use of Furazolidone in the treatment of burns and wound infections. In such conditions, the medication is used topically, in the form of irrigation with a solution or wet-dry dressings.

    Side effects

    The drug "Furazolidone" is a low-toxic drug. But despite this, it can still contribute to the development of adverse reactions. These include nausea, lack of appetite, vomiting and epigastric pain.

    According to the instructions, this medication rarely leads to allergic reactions. Sometimes, against the background of its prima, urticaria, skin rash, Quincke's edema and severe itching develop.

    To prevent the occurrence of adverse reactions, it is recommended to take each dose of the drug with a large volume of liquid, and, if necessary, take B vitamins and antihistamines.

    At long-term use tablets, especially in young children, the development of hemolytic anemia, methemoglobinemia, hyperthermia, shortness of breath, cough and neurotoxic reaction is possible.

    Similar means

    If the medication in question is contraindicated for you, then it can be replaced with drugs such as Lekor and Fastin. Also analogues of this product are “Furacilin”, “Makmiror”, “Furasol” and “Furamag”.

    Furazolidone tablets: price, reviews

    Price this tool not very high. You can buy 20 antibacterial tablets for 40-50 rubles.

    What do consumers say about the drug "Furazolidone"? Every patient who has ever used it can leave a review of this medicine. According to the majority, the medication in question is particularly effective in the treatment of diseases of the genitourinary system. After several days of taking the pills, symptoms of cystitis, urethritis and other pathological conditions disappear immediately. As for side effects, they occur extremely rarely.

    Furazolidone belongs to the nitrofuran group of antibiotics. The instructions for use indicate that this drug is used in the treatment of a number of diseases. This:

    • Dysentery and salmonellosis;
    • typhus and paratyphoid;
    • cholera;
    • giardiasis;
    • food poisoning;
    • trichomonas lesions of the genitourinary system;
    • cystitis;
    • treatment of infected wounds using the drug topically.

    Many of the above pathologies have diarrhea as their main symptom. But there is also infectious lesions internal organs and systems.

    Furazolidone has limited effectiveness against fungal flora. In addition, the product has a number of contraindications. Therefore, the question arises: what to replace Furazolidone with?

    Let's make a list of substitutes for a familiar drug.

    The phenomenon is familiar to both adults and children. There are many reasons for diarrhea - from banal overeating or errors in diet, to serious pathologies organs gastrointestinal tract. Consequently, there are many drugs that act on this unpleasant symptom and are effective against various pathogens.

    Furadonin’s “brother” in the fight against diarrhea is Loperamide. This means, so to speak, is situational ambulance with diarrhea. After administration, the effect appears within 40-50 minutes.

    For effective disposal For diarrhea, it is recommended to immediately take two Loperamide tablets with plenty of water. Then one tablet after each loose stool, but not more than 10 tablets per day. After taking the drug, constipation and inhibition of intestinal motility are possible.

    If diarrhea does not go away within two days while taking Loperamide, you need to contact a specialist and change the drug. It is usually not prescribed in courses and has a number of contraindications.

    We already know that Furazolidone belongs to the antibiotic class of drugs, but it has a slight immunostimulating effect. In other words, it does not inhibit the beneficial microflora of the stomach and intestines. An analogue of Furazolidone in terms of its effect on beneficial microflora is the probiotic Enterol. It not only fights diarrhea, but is also recommended for simultaneous administration with tetracycline and cephalosporin antibiotics to avoid problems with the gastrointestinal tract.

    Therapy of other pathologies

    The instructions for use of the “hero of our novel” indicate not only the pathologies that cause stool disorders, but also some others. In this regard, there are also quite worthy analogues of Furazolidone. Let us consider them in relation to the pathologies for which they are prescribed.

    Inflammatory processes of the genitourinary system

    Since the highest concentration of Furazolidone is observed in the intestinal lumen, it is precisely when intestinal infection its effectiveness is maximum. But it is used for the treatment of cystitis as a mono-drug only in uncomplicated forms of the pathology.

    In the case of cystitis, if you choose which is more effective - Furazolidone or Furadonin, then the second drug works better. But it is more toxic and has a significant list of contraindications and side effects, including digestive disorders and dyspepsia.

    In this regard, the question of which is better, Furazolidone or Furagin, remains relevant:

    The next question is Furazolidone or Macmiror? These two drugs can be used interchangeably in the fight against such ailments:

    • Giardiasis;
    • pathologies of the urinary system.

    Macmiror is still indicated in treatment gynecological pathologies fungal and infectious origin, as well as inflammatory diseases upper sections Gastrointestinal tract.

    In the treatment of infected wounds, Furazolidone or Furacilin can be used as a local antiseptic. The difference between these drugs is that Furacilin is used only topically and has a limited range of applications. It is contraindicated for children under five years of age, pregnant and lactating women. Long-term use may cause adverse reactions in the form of an allergy, and if used as a mouth rinse, angioedema is possible.

    None of the products are available with a prescription. But this does not mean that they can be used uncontrolled, and if any side effects occur while taking Furazolidone, you can independently replace the drug.

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