How to restart the immune system. Multiple sclerosis was cured by “rebooting” the immune system. Other benefits of intermittent fasting

Short-term fasting restarts the immune system and restores the body. Constant fasting is harmful to the body, but we're talking about about short-term fasting. It is recommended not only various kinds practices aimed at spiritual development, but also modern science confirms its benefits.

At the same time, short-term fasting helps cleanse the body, rapid loss weight and natural renewal cells and strengthening immune system. Estet-portal.com will explain how short-term fasting is beneficial for the immune system, how not to overdo it with a hunger strike and get the maximum health benefits from it.

Short-term fasting for immunity - backed by science

Researchers from the University of Southern California published their findings on healthy aging in the journal Cell Stem Cell.

The fact is that when you are fasting, the body tries to save energy, and one of the ways to do this is to “recycle” many immune cells in which it this moment does not need. Damaged cells of the immune system are especially targeted. So says study co-author Valter Longo, a professor at the University of Southern California Davis School of Gerontology and director of the University of Southern California Longevity Institute.

The process described above, which explains the benefits of fasting for the immune system, is characteristic of both humans and animals.

In studies conducted on both mice and human volunteers, experts deprived the subjects of food, which led to a decrease in the number of white blood cells in the body. They are responsible for fighting diseases and filling the blood in the event of pathogenic agents entering the blood.

However, the matter did not end with a drop in leukocyte levels: the fasting cycle led to a natural “restart” of leukocyte production.

After 2–4 days of fasting, the hematopoietic system destroyed older and damaged immune cells and formed new ones. Scientists believe that short-term fasting is beneficial not only for the immune system, but also for other systems and organs of the body.

The effects of short-term fasting on other body systems

Short-term fasting causes the body to store sugars, fats and ketones and destroy significant amounts of white blood cells. Ketones are produced when the body converts fat into energy and are major players in the weight loss arena.

Short-term fasting allows the body to use fat as its main source of energy. It helps speed up metabolism and improve intestinal peristalsis, giving digestive system take a break. Such a break in food intake contributes to more efficient combustion calories, as if reminding the body of the correct digestive process.

Short-term fasting is like a reset button for the whole body. It creates a healthy environment in which the body releases regulated hormones to learn to recognize real hunger. If a person eats every 3-4 hours, his body has no idea what real hunger is. By freeing the body from the digestive process for 12–24 hours, you give it the opportunity to focus on the regeneration of other systems.

Also, short-term fasting helps remove toxins from the body and regulate the functioning of the “filtering” organs - the liver and kidneys.

Important! The fasting period should not exceed four days, and throughout the entire fasting period it is necessary to increase the amount of water consumed.

With each “session” of short-term fasting, the depletion of the white blood cell population leads to the formation of new immune system cells. When the enzyme protein kinase A (PKA) levels decreased along with the number of white blood cells, the researchers realized that there was a “switch” in the body that made possible formation new cells and leads to decreased levels of IGF-1, which is associated with aging, tumor growth and cancer risk.

To transfer stem cells to regeneration mode, it is necessary to turn off the action of PKA, as a result of which stem cells begin to proliferate and, accordingly, lead to a renewal of the system.

Also, the healing effect of short-term fasting is to get rid of damaged or old elements that are no longer able to work effectively. This explains beneficial influence short-term fasting on the immune system after chemotherapy - it (the immune system) is simply renewed.

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Most common problem, which occurs after transplantation of donor organs, is the rejection of the transplanted implant by the recipient’s immune system. To avoid this, patients have to take a lot of toxic drugs, the side effects of which can lead to the most unexpected results.

To help people, researchers have developed new technique“reboot” the immune system, which is much safer than any alternatives. During clinical trials, it was tested on 20 volunteers with kidney transplants.

IN normal situation they would have to take up to 20 drugs daily and be at risk of developing cancer and renal failure and also suffer from side effects in the form of diarrhea and bloating.

Led clinical trials Dr. Alan Kirk from Emory University in Atlanta. He restarted the patient's immune system so that it accepted the transplanted kidney as if it were its own.

According to a study report published in the American Journal of Transplantation, seven patients subsequently required one injection per day, and the remaining thirteen required one injection and one tablet daily.

The technique developed by Dr. Kirk and his colleagues is based on three key components. The first is a drug called alemtuzumab, which is given intravenously during surgery. It “washes out” white blood cells, lymphocytes, which are the first to attack the newly transplanted organ. Subsequently, they recover within 12-18 months, but after that they no longer perceive the transplanted organ as foreign.

"This is the immune system's reset button," Kirk explains.

The second drug is called belatacept. Its job is to force new lymphocytes to accept the implant and not reject it. At first, injections must be given quite often, but then injections are given only once a month for six months.

The last drug, sirolimus, is a mild immunosuppressant and is taken in tablet form. Its presence is rather a precautionary measure: it rids the body of the remaining “aggressive” lymphocytes, which for some reason survived after the administration of alemtuzumab.

One year after surgery, no patient showed signs of rejection. Moreover, none of them required additional medications. Doctors asked ten subjects if they wanted to stop taking sirolimus, and almost all did so, except three people who decided to play it safe. These seven receive monthly belatacept injections, which is their only maintenance therapy.

Three and a half years after the operation, all 20 patients feel great. Since then, Kirk has tried this technique on 18 more volunteers who were no longer given sirolimus. Second tests also gave positive result. The final stage will begin in May 2014 clinical tests, which will involve many more patients.

Kirk said he eventually plans to get the technology to the point where even taking belatacept is optional. He tried stopping the drug in two patients, but had to be reinstated at the first hint of implant failure.

In the future, tests will be carried out on other organs besides the kidneys.

Constant fasting is harmful to the body, but when it comes to short-term fasting, not only various types of practices aimed at spiritual development, but also modern science confirm its benefits. At the same time, short-term fasting not only promotes cleansing of the body and rapid weight loss, but also natural cell renewal and strengthening of the immune system. the site will explain how short-term fasting is beneficial for the immune system, how not to overdo it with a fast and get the maximum health benefits from it.

Short-term fasting for immunity - backed by science

Researchers from the University of Southern California published their findings on healthy aging in the journal Cell Stem Cell.

The fact is that when you are fasting, the body tries to save energy, and one of the ways to do this is to “recycle” many immune cells that it does not currently need. Damaged cells of the immune system are especially targeted. So says study co-author Valter Longo, a professor at the University of Southern California Davis School of Gerontology and director of the University of Southern California Longevity Institute.

The process described above, which explains the benefits of fasting for the immune system, is characteristic of both humans and animals.

In studies conducted on both mice and humans, experts deprived the subjects of food, which led to a decrease in the number of white blood cells in the body. They are responsible for fighting diseases and filling the blood in the event of pathogenic agents entering the blood. However, the matter did not end with a drop in leukocyte levels: the fasting cycle led to a natural “restart” of leukocyte production.

After 2-4 days of fasting, the hematopoietic system destroyed older and damaged immune cells and formed new ones. Scientists believe that short-term fasting is beneficial not only for the immune system, but also for other systems and organs of the body.

The effects of short-term fasting on other body systems

Short-term fasting causes the body to store sugars, fats and ketones and destroy a significant number of white blood cells. Ketones are produced when the body converts fat into energy and are major players in the weight loss arena.

Short-term fasting allows the body to use fat as its main source of energy. It helps speed up metabolism and improve intestinal motility, giving the digestive system a break. Such a break in food intake promotes more efficient calorie burning, as if reminding the body of the proper digestive process.

Short-term fasting is like a reset button for the whole body. It creates a healthy environment in which the body releases regulated hormones to learn to recognize real hunger. If a person eats every 3-4 hours, his body has no idea what real hunger is. By freeing the body from the digestive process for 12-24 hours, you give it the opportunity to focus on the regeneration of other systems.

Also, short-term fasting helps remove toxins from the body and regulate the functioning of the “filtering” organs - the liver and kidneys.

Important! The fasting period should not exceed four days, and throughout the entire fasting period it is necessary to increase the amount of water consumed.

With each “session” of short-term fasting, the depletion of the white blood cell population leads to the formation of new immune system cells. When levels of the enzyme protein kinase A (PKA) decreased along with the number of white blood cells, the researchers realized that a "switch" was occurring in the body that allowed the formation of new cells and led to a decrease in the level of IGF-1, which is associated with aging, tumor growth and the risk of developing cancer.

To transfer stem cells into regeneration mode, it is necessary to turn off the action of PKA, as a result of which stem cells begin to proliferate and, accordingly, lead to a renewal of the system.

Also, the healing effect of short-term fasting is to get rid of damaged or old elements that are no longer able to work effectively. This explains the beneficial effect of short-term fasting on the immune system after chemotherapy - it (the immune system) is simply renewed.

I recently wrote about how similar viruses are in biology and in computer science, and how this could be used. Moreover, a few days later I came across a note that said that cunning computer scientists were the first to decide to adapt virological techniques for their own purposes.
And today I came across a note where another common word appeared - this time immunologists hijacked the term “reboot” from computer scientists.
The note talks about treating diabetes using the “reboot” method.
“American and Brazilian researchers managed to relieve patients with type 1 diabetes from insulin dependence using a kind of “reboot” of the immune system.
The joint study by researchers from Northwestern University in Chicago, Illinois, USA, and the Regional Blood Center in Ribeirão Preto, São Paulo, Brazil, included 23 people with type 1 diabetes on insulin replacement therapy.
First, stem cells were collected and preserved from patients. bone marrow. Then, with the help of chemotherapy, they destroyed all the patients’ immune cells in order to cleanse the body of the population that attacks islet cells pancreas, which produces insulin (this process is the basis of type 1 diabetes). After this, the immune system was restored with preserved stem cells."

This note is probably clear to some readers. More precisely, the approach itself is the treatment of diseases in the pathogenesis of which cells of the immune system, the so-called, participate. reboot. In the described case, a reboot is carried out with chemotherapy.
A more traditional, well-tested and widely used method is BM transplantation, in which the cells of the immune system are also killed - only usually by irradiation. By the way, I don’t know what determines which method is better - I’ll be grateful if anyone can tell me.
A reboot is also essentially a bone marrow transplant, only they are transplanting not donor cells, but their own hematopoietic cells, which are obviously compatible. The idea is to eliminate the consequences of the fact that the immune system once went “down a bad path” - it began to consider strangers and attack its own own cells in the pancreas. If it happened “by accident”, i.e. under the influence of an external stimulus, then the immune system should not make this mistake a second time.
On the other hand, a predisposition to diabetes mellitus has a pronounced hereditary component. So, even if the entire population of auto-aggressive cells can be eliminated during a reboot and the external stimulus does not recur, there should still be a high chance of getting sick again after a reboot.
But the reboot method is designed not only to cure, but also to reduce insulin dependence. And this task is easier for him to cope with. The results so far are:
“A positive effect of treatment was achieved in 20 participants in the experiment. 12 patients have not yet needed insulin injections, while one of them underwent a “reboot” of the immune system five years ago, four - three years, three - two years, and the rest - a year ago. After some time, the rest had to resume taking insulin, but in significantly lower doses than before treatment. Two of them were able to get rid of insulin dependence after prescribing the glucose-lowering drug sitagliptin. For three patients, the treatment did not help. In nine participants in the experiment, it was complicated by a decrease in concentration sperm in the ejaculate."
Two also had pneumonia. None of the participants in the experiment died.
The method was met with great doubts at first (2007), and the current sample of patients is clearly too small. New, more extensive clinical trials are now being planned.
In general, it turns out that the reboot method is used, or rather, is being studied, for the treatment of another autoimmune disease - multiple sclerosis. The same Richard Barth from the same Northwestern University in Chicago. We should somehow try to get to his lecture before they take him to some Harvard and give him Nobel Prize- otherwise it will be difficult to get there :)
The beauty of the method is that it is not specific to either diabetes or multiple sclerosis. It is in principle suitable for the treatment of any autoimmune disease. And the list of them is long, and it is regularly discovered that some time ago known disease is autoimmune. I personally keep my fingers crossed for this method.