Piralgin. Pentalgin-N - official* instructions for use Pentalgin and what prescription form it is prescribed on

- 0.008 g, caffeine - 0.05 g.

Excipients: talc, potato starch, magnesium stearate.

Composition of Piralgin in Latin:

Metamizolesodium - 0.3 g, phenobarbital - 0.01 g, naproxen - 0.1 g, codeine - 0.008 g, caffeine -0.05 g. Adjuvans: talc, amylumsolani, magnesium stearate.

Release form

Pills.

pharmachologic effect

Analgesic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Piralgin is a combination drug that has the properties non-narcotic analgesics And NSAIDs . Analgesic And anti-inflammatory effect manifests itself through content naproxen And metamizole sodium .

The analgesic effect is enhanced codeine , which blocks opiate receptors and changes the perception of pain. Besides, codeine, suppressing the excitability of the cough center, has an antitussive effect. It has a less depressant effect on the respiratory center than morphine and is less likely to cause nausea and vomiting. Antitussive effect relieves the condition of colds.

Caffeine dilates blood vessels in the brain, skeletal muscles and heart. Eliminates drowsiness, increases physical performance and blood pressure during hypotension . Caffeine eliminates headache . By increasing the permeability of blood barriers, it increases the bioavailability of other components of the drug, which enhances their therapeutic effect. Phenobarbital It has sedative effect , increases the efficiency of action metamizole And naproxen . The duration of action of the drug is 5-6 hours.

Pharmacokinetics

All components of the drug are well absorbed. Metamizole sodium hydrolyzes in the intestinal wall. Its active metabolite is 50-60% protein bound. Metabolites are excreted by the kidneys.

Caffeine has a half-life of 6 to 10 hours. Excreted by the kidneys. Codeine binds to proteins in small quantities. Metabolized in the liver. Excreted by the kidneys.

Bioavailability naproxen 95%. The half-life is 12-14 hours. It is mainly excreted in urine and in small quantities in bile.

Bioavailability phenobarbital 80%. Binds to proteins by 50%, penetrates the placenta. Metabolized in the liver. Excreted by the kidneys.

Indications for use

Piralgin is prescribed for pain syndrome :

• muscle pain and arthralgia ;
• menstrual pain ;
• headache , neuralgia ;
• toothache;
• inflammatory diseases with pain syndrome;
• febrile conditions .

Contraindications

• hypersensitivity to the components of the drug;
• pronounced hepatic or ;
• anemia , leukopenia ;
• exacerbation ;
• spicy ;
• increased intracranial pressure;
• pregnancy , lactation;
• elderly age;
• age up to 12 years.

For acute abdominal pain Do not take the drug for unknown etiology, as this complicates the diagnosis.

Side effects

• , rash , itching ;
• , drowsiness , lethargy ;
• asthenic conditions;
• nausea , ;
• , leukopenia , granulocytopenia .

With uncontrolled use in dosages exceeding the maximum permissible, there is a possibility of addiction, which is expressed in a weakening of the analgesic effect. Drug dependence may develop codeine .

Instructions for use of Piralgin (Method and dosage)

Take 1 tablet orally 2-3 times a day. You should not take more than 4 tablets. Children over 12 years of age take half the adult dose.

The instructions for use of Piralgin contain warnings: with long-term treatment (more than a week), you need to monitor your blood test. Without a doctor's recommendation, you can take up to 3 days; if you have pain, no more than 5 days.

Overdose

Overdose is manifested by symptoms: pain in the stomach, nausea , vomit , depression of the respiratory center , tachycardia , arrhythmias . Gastric lavage is performed, sorbents and symptomatic therapy.

*registered by the Ministry of Health of the Russian Federation (according to grls.rosminzdrav.ru)

Registration number:

Active substance:

caffeine, codeine, metamizole sodium, naproxen, phenobarbital

Dosage form:

Compound:

Composition per tablet:

Active substances: metamizole sodium (analgin) - 300 mg, naproxen - 100 mg, caffeine - 50 mg, codeine or codeine phosphate in terms of codeine - 8 mg, phenobarbital - 10 mg.

Excipients: potato starch - 242 mg, low molecular weight povidone (low molecular weight medical polyvinylpyrrolidone) - 9 mg, sodium citrate - 4 mg, magnesium stearate - 7 mg.

Description:

tablets are white or white with a yellowish or creamy tint, flat-cylindrical. The abbreviated name of the drug “PENT-N” is applied to one side of the tablet using embossing.

Pharmacotherapeutic group:

ATX:

Pharmacodynamics:

The combined drug has analgesic, anti-inflammatory and antipyretic effects.

Naproxen and
metamizole sodium - have analgesic and anti-inflammatory effects.

Codeine stimulates opiate receptors in various parts of the central nervous system, which leads to activation of the antinoceceptive system and a change in the emotional perception of pain.
Phenobarbital and
codeine increases the analgesic effectiveness of metamizole sodium and naproxen.

Caffeine causes dilation of blood vessels in skeletal muscles, brain, heart, kidneys; increases mental and physical performance, helps eliminate fatigue and drowsiness; increases the permeability of histohematic barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect.

Pharmacokinetics:

The components of the drug are well absorbed in the gastrointestinal tract.

Metamizole sodium: in the intestinal wall it is hydrolyzed to form the active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites. The level of binding of the active metabolite to proteins is 50-60%. Excretion of metabolites occurs through the kidneys. In addition, metabolites are excreted in breast milk.

Naproxen: bioavailability is 95%. Binds to blood proteins. The half-life is 12-15 hours. It is excreted in the urine mainly in the form of a metabolite (dimethylnaproxen), in small quantities - in bile.

Caffeine: well absorbed in the intestine, half-life is 5 hours (sometimes up to 10 hours). It is excreted mainly by the kidneys in the form of metabolites, about 10% - unchanged.

Codeine: slightly binds to plasma proteins. Undergoes biotransformation in the liver (10% by demethylation goes into
morphine). Excreted by the kidneys (5-15% unchanged).

Phenobarbital: bioavailability is 80%. In plasma it binds to proteins by 50%, penetrates well through the placenta. Biotransformed in the liver. The main metabolite has no pharmacological activity. It is excreted by the kidneys, including 20-25% unchanged.

Indications for use

Taken for mild and moderately severe pain of various origins (including pain in joints, muscles, radiculitis, menstrual pain, neuralgia, as well as headaches, migraines, toothaches). Can be used for feverish conditions, colds and other diseases accompanied by pain and inflammation.

Contraindications

Hypersensitivity, severe liver and/or kidney failure, peptic ulcer of the stomach and duodenum in the acute stage, bronchial asthma, bronchospasm. Conditions accompanied by respiratory depression. Glucose-6-phosphate dehydrogenase deficiency; anemia, leukopenia; conditions accompanied by respiratory depression; traumatic brain injury, acute myocardial infarction; arrhythmias, severe arterial hypertension, alcohol intoxication, glaucoma, children (up to 12 years).

Carefully:

Pregnancy and lactation:

The drug is contraindicated for use during pregnancy.

If it is necessary to use the drug during lactation, it is necessary to decide on stopping breastfeeding.

Directions for use and doses

The drug is usually taken 1 tablet 1-3 times a day. The maximum daily dose is 4 tablets. The drug should not be taken for more than 5 days as an analgesic and for more than 3 days as an antipyretic without a doctor’s prescription.

Side effect

Overdose:

Symptoms: nausea, vomiting, stomach pain, tachycardia, cardiac arrhythmias, weakness, drowsiness, delirium, respiratory depression.

Treatment: induction of vomiting, transtube gastric lavage, administration of adsorbents (activated carbon), symptomatic therapy aimed at maintaining vital functions.

Interaction

Special instructions:

When used for more than 5 days, monitoring of the peripheral blood picture and the functional state of the liver is necessary.

Due to the presence of codeine and phenobarbital in the drug, it is possible to obtain positive results when using test systems, including during doping control.

It makes it difficult to establish a diagnosis in acute abdominal pain syndrome.

Patients suffering from atopic bronchial asthma and hay fever have an increased risk of developing hypersensitivity reactions.

Effect on ability to drive:

Release form:

pills.

Package:

10 tablets in a blister pack.

1 or 2 blister packs with instructions for use in a cardboard pack.

Storage conditions:

Store at a temperature not exceeding 25 °C. Keep out of the reach of children.

Best before date:

3 years. Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies:

Registration Certificate Holder:

Manufacturer

Representation:

The combined drug has analgesic, antipyretic and anti-inflammatory effects.

Metamizole sodium is an analgesic-antipyretic, a pyrazolone derivative. Has a pronounced analgesic effect.

Naproxen is an NSAID that has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of COX activity, which regulates the synthesis of prostaglandins.

Caffeine causes dilation of blood vessels in skeletal muscles, brain, heart, and kidneys. Increases mental and physical performance, helps eliminate fatigue and drowsiness. Increases the permeability of histohematic barriers and increases the bioavailability of non-opioid analgesics, thereby enhancing the therapeutic effect.

Codeine stimulates opioid receptors in various parts of the central nervous system, which leads to activation of the antinociceptive system and a change in the emotional perception of pain.

Phenobarbital and codeine increase the analgesic effect of metamizole sodium and naproxen.

Pharmacokinetics

The components of the drug are well absorbed from the gastrointestinal tract.

Metamizole sodium

In the intestinal wall it is hydrolyzed to form the active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites. The binding of the active metabolite to proteins is 50-60%. Metabolites are excreted by the kidneys and excreted in breast milk.

Naproxen

Bioavailability is 95%. Binds to blood proteins. T1/2 - 12-15 hours. Excreted in the urine mainly in the form of a metabolite (dimethylnaproxen), in small quantities - in bile.

Well absorbed in the intestines. T 1/2 - 5 hours (sometimes up to 10 hours). It is excreted mainly by the kidneys in the form of metabolites, about 10% - unchanged.

Slightly binds to plasma proteins. It undergoes biotransformation in the liver (10% goes into morphine by demethylation). Excreted by the kidneys (5-15% unchanged).

Phenobarbital

Bioavailability is 80%. Binding to blood plasma proteins - 50%. Penetrates well through the placental barrier. Biotransformed in the liver. The main metabolite has no pharmacological activity. Excreted by the kidneys, incl. 20-25% - unchanged.

Release form

Tablets are white or white with a yellowish or creamy tint, flat-cylindrical, with the abbreviated name of the drug "PENT-N" embossed on one side.

Excipients: potato starch, low molecular weight polyvinylpyrrolidone (povidone), sodium citrate, magnesium stearate.

10 pieces. - contour cellular packaging (1) - cardboard packs.

Dosage

The drug is prescribed 1 tablet. 1-3 times/day. The maximum daily dose is 4 tablets.

The drug should not be taken for more than 5 days as an analgesic and for more than 3 days as an antipyretic without a doctor’s prescription.

Overdose

Symptoms: nausea, vomiting, gastralgia, drowsiness, tachycardia, cardiac arrhythmias, delirium, weakness, respiratory depression.

Treatment: induction of vomiting, gastric lavage through a tube, administration of adsorbents (activated carbon), symptomatic therapy aimed at maintaining vital functions.

Interaction

Concomitant use of the drug with other non-opioid analgesics may lead to increased toxic effects.

Tricyclic antidepressants, oral contraceptives, and allopurinol increase the toxicity of metamizole sodium, which is part of the drug.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effect of metamizole sodium.

The simultaneous use of metamizole sodium with cyclosporine reduces the level of the latter in the blood.

Sedatives and tranquilizers enhance the analgesic effect of the drug.

Side effects

From the digestive system: epigastric pain, nausea, vomiting, constipation; with long-term use in high doses - liver dysfunction.

From the hematopoietic system: rarely - inhibition of hematopoiesis (leukopenia, granulocytopenia, agranulocytosis).

From the side of the central nervous system: dizziness, drowsiness.

From the cardiovascular system: palpitations.

From the urinary system: with long-term use in high doses - impaired renal function.

Allergic reactions: skin rash, itching, urticaria.

Indications

• mild and moderate pain syndrome of various origins (including pain in joints, muscles, radiculitis, algodismenorrhea, neuralgia, headache, migraine, toothache);
• fevers, colds and other diseases accompanied by pain and inflammation.

Contraindications

• severe liver failure;
• severe renal failure;
• peptic ulcer of the stomach and duodenum in the acute phase;
• bronchial asthma;
• bronchospasm;
• anemia, leukopenia;
• conditions accompanied by respiratory depression;
• traumatic brain injury;
• severe arterial hypertension;
• acute myocardial infarction;
• arrhythmias;
• alcohol intoxication;
• glaucoma;
• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• children under 12 years of age;
• hypersensitivity to the components of the drug.

The drug should be used with caution in mild to moderate arterial hypertension, gastric and/or duodenal ulcers in remission, as well as in elderly patients.

Features of application

Use during pregnancy and breastfeeding

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.

Use for liver dysfunction

Use for renal impairment

Use in children

Use in elderly patients

special instructions

With long-term (more than 5 days) use of the drug, it is necessary to monitor the peripheral blood picture and liver function indicators.

Taking the drug Pentalgin ® -N may complicate the diagnosis of acute abdominal pain syndrome.

Patients with atopic bronchial asthma and hay fever have an increased risk of developing hypersensitivity reactions while taking the drug Pentalgin ® -N.

The use of the drug may change the results of doping control in athletes.

Impact on the ability to drive vehicles and operate machinery

When taking the drug Pentalgin ® -N, you should refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Pentalgin N is a combination drug that has analgesic, antipyretic and anti-inflammatory effects.

Active ingredients – Codeine + Caffeine + Metamizole sodium + Naproxen + Phenobarbital.

The therapeutic effect of the drug is based on the action of the components:

• Naproxen and metamizole sodium have analgesic and anti-inflammatory effects.
• Codeine stimulates opioid receptors in various parts of the central nervous system, which leads to activation of the antinociceptive system and a change in the emotional perception of pain. The antitussive effect alleviates the condition of patients with colds.
• Phenobarbital increases the analgesic effect of metamizole sodium and naproxen.
• Caffeine causes dilation of blood vessels in skeletal muscles, brain, heart, and kidneys. Increases mental and physical performance, helps eliminate fatigue and drowsiness. Increases the permeability of histohematic barriers and increases the bioavailability of non-opioid analgesics, thereby enhancing the therapeutic effect.

All components of the drug undergo excellent absorption in the gastrointestinal tract. As a result of metabolism, several active metabolites are formed.

The protein binding rate is about 60%. Substances are mainly excreted from the body in metabolites and a small part, approximately 10%, in unchanged form.

Indications for use

What does Pentalgin N help with? According to the instructions, the drug is prescribed in the following cases:

• pain syndrome of various origins of weak and moderate severity (including headache, neuralgia, migraine, pain in muscles, joints, radiculitis, toothache, algodismenorrhea);
• colds and other diseases accompanied by fever, inflammation and pain.

Instructions for use Pentalgin N, dosage

The tablets are taken orally with clean water. Best 1 hour after eating.

The standard dosage of Pentalgin N according to the instructions is 1 tablet once \ up to 3 times a day, every 6 hours.

The maximum daily dosage is 4 tablets per day.

You should not take the drug for more than 5 days as an analgesic and for more than 3 days as an antipyretic.

Precautionary measures

Caution should be used in case of impaired liver and kidney function, gastric and duodenal ulcers (in remission), and elderly patients.

With long-term use, it is necessary to monitor the composition of peripheral blood.

During therapy, alcohol should be avoided and prescribed with caution to vehicle drivers and people whose profession involves increased concentration.

Side effects

The instructions warn about the possibility of developing the following side effects when prescribing Pentalgin N:

• From the central nervous system: dizziness, drowsiness;
• From the digestive system: nausea, vomiting, pain in the epigastric region, constipation; with prolonged use of high doses – liver dysfunction;
• From the cardiovascular system: palpitations;
• From the hematopoietic system: rarely - hematopoietic disorders (granulocytopenia, leukopenia, agranulocytosis);
• From the urinary system: with prolonged use in high doses - impaired renal function;
• Allergic reactions: itching, skin rash, urticaria.

Excessive consumption of caffeine-containing products (coffee, tea) during treatment may cause overdose symptoms.

Patients suffering from atopic bronchial asthma and hay fever have an increased risk of developing allergic reactions.

Contraindications

It is contraindicated to prescribe Pentalgin N in the following cases:

• severe liver failure;
• severe renal failure;
• peptic ulcer of the stomach and duodenum in the acute phase;
• bronchial asthma;
• bronchospasm;
• anemia, leukopenia;
• conditions accompanied by respiratory depression;
• traumatic brain injury;
• severe arterial hypertension;
• acute myocardial infarction;
• arrhythmias;
• alcohol intoxication;
• glaucoma;
• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy and breastfeeding;
• children under 12 years of age;
• hypersensitivity to the components of the drug.

The drug should be used with caution in mild to moderate arterial hypertension, gastric and/or duodenal ulcers in remission, as well as in elderly patients.

Overdose

Symptoms of overdose are nausea, vomiting, gastralgia, drowsiness, tachycardia, cardiac arrhythmias, delirium, weakness, respiratory depression.

According to indications, symptomatic therapy is carried out aimed at maintaining vital functions.

Analogs Pentalgin N, price in pharmacies

If necessary, you can replace Pentalgin N with an analogue in terms of therapeutic effects - these are the following drugs:

1. Piralgin,
2. Baralgin M,
3. Maxigan,
4. Spasmalin,
5. Tetralgin,
6. Banalgin.

When choosing analogues, it is important to understand that the instructions for use of Pentalgin N, the price and reviews do not apply to drugs with similar effects. It is important to consult a doctor and not change the drug yourself.

Price in Russian pharmacies: Pentalgin N tablets 24 pcs - from 200 to 275 rubles, 10 pcs. – from 159 rubles, according to 592 pharmacies.

Store in a dry place, protected from light, at a temperature not exceeding 25 °C. Keep away from children. Shelf life – 3 years. Dispensing conditions from pharmacies are by prescription.

Analgesic-antipyretic combined composition

Active ingredients

Caffeine
- metamizole sodium (metamizole sodium)
- (phenobarbital)
- naproxen
- codeine (in phosphate form) (codeine)

Release form, composition and packaging

Pills white or white with a yellowish or creamy tint, flat-cylindrical, with the abbreviated name of the drug "PENT-N" embossed on one side.

Excipients: potato starch, low molecular weight polyvinylpyrrolidone (), sodium citrate, magnesium stearate.

10 pieces. - contour cellular packaging (1) - cardboard packs.

pharmachologic effect

The combined drug has analgesic, antipyretic and anti-inflammatory effects.

Metamizole sodium- analgesic-antipyretic, pyrazolone derivative. Has a pronounced analgesic effect.

Naproxen- NSAIDs have anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of COX activity, which regulates the synthesis of prostaglandins.

Caffeine causes dilation of blood vessels in skeletal muscles, brain, heart, and kidneys. Increases mental and physical performance, helps eliminate fatigue and drowsiness. Increases the permeability of histohematic barriers and increases the bioavailability of non-opioid drugs, thereby enhancing the therapeutic effect.

Codeine stimulates opioid receptors in various parts of the central nervous system, which leads to activation of the antinociceptive system and a change in the emotional perception of pain.

Phenobarbital and codeine increase the analgesic effect of metamizole sodium and naproxen.

Pharmacokinetics

The components of the drug are well absorbed from the gastrointestinal tract.

Metamizole sodium

In the intestinal wall it is hydrolyzed to form the active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites. The binding of the active metabolite to proteins is 50-60%. Metabolites are excreted by the kidneys and excreted in breast milk.

Naproxen

Bioavailability is 95%. Binds to blood proteins. T1/2 - 12-15 hours. Excreted in the urine mainly in the form of a metabolite (dimethylnaproxen), in small quantities - in bile.

Caffeine

Well absorbed in the intestines. T 1/2 - 5 hours (sometimes up to 10 hours). It is excreted mainly by the kidneys in the form of metabolites, about 10% - unchanged.

Codeine

Slightly protein bound. It undergoes biotransformation in the liver (10% goes into morphine by demethylation). Excreted by the kidneys (5-15% unchanged).

Phenobarbital

Bioavailability is 80%. Binding to blood plasma proteins - 50%. Penetrates well through the placental barrier. Biotransformed in the liver. The main metabolite has no pharmacological activity. Excreted by the kidneys, incl. 20-25% - unchanged.

Indications

— mild and moderate pain syndrome of various origins (including pain in joints, muscles, radiculitis, algodismenorrhea, neuralgia, headache, migraine, toothache);

— febrile conditions, colds and other diseases accompanied by pain and inflammation.

Contraindications

- severe liver failure;

- severe renal failure;

- peptic ulcer of the stomach and duodenum in the acute phase;

- bronchial asthma;

- bronchospasm;

- anemia, leukopenia;

- conditions accompanied by respiratory depression;

- traumatic brain injury;

- severe arterial hypertension;

- acute myocardial infarction;

- arrhythmias;

- alcohol intoxication;

- glaucoma;

- deficiency of glucose-6-phosphate dehydrogenase;

- pregnancy;

- children under 12 years of age;

- hypersensitivity to the components of the drug.

WITH caution The drug should be used for mild to moderate arterial hypertension, gastric and/or duodenal ulcers in remission, as well as in elderly patients.

Dosage

The drug is prescribed 1 tablet. 1-3 times/day. The maximum daily dose is 4 tablets.

The drug should not be taken for more than 5 days as an analgesic and for more than 3 days as an antipyretic without a doctor’s prescription.

Side effects

From the digestive system: epigastric pain, nausea, vomiting, constipation; with long-term use in high doses - liver dysfunction.

From the hematopoietic system: rarely - inhibition of hematopoiesis (leukopenia, granulocytopenia, agranulocytosis).

From the side of the central nervous system: dizziness, drowsiness.

From the cardiovascular system: heartbeat.

From the urinary system: with long-term use in high doses - impaired renal function.

Allergic reactions: skin rash, itching, urticaria.

Overdose

Symptoms: nausea, vomiting, gastralgia, drowsiness, tachycardia, cardiac arrhythmias, delirium, weakness, respiratory depression.

Treatment: induction of vomiting, gastric lavage through a tube, administration of adsorbents (activated carbon), symptomatic therapy aimed at maintaining vital functions.

Drug interactions

Concomitant use of the drug with other non-opioid analgesics may lead to increased toxic effects.

Tricyclic antidepressants and oral contraceptives increase the toxicity of metamizole sodium, which is part of the drug.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effect of metamizole sodium.

The simultaneous use of metamizole sodium with reduces the level of the latter in the blood.

Sedatives and tranquilizers enhance the analgesic effect of the drug.

special instructions

With long-term (more than 5 days) use of the drug, it is necessary to monitor the peripheral blood picture and liver function indicators.

Taking the drug Pentalgin-N may complicate the diagnosis of acute abdominal pain syndrome.

Patients with atopic bronchial asthma and hay fever have an increased risk of developing hypersensitivity reactions while taking the drug Pentalgin-N.