Furosemide diuretic tablets. Powerful loop diuretic Furosemide: what is a medication with an active diuretic effect prescribed for and how to use it

The successful functioning of the human body requires careful monitoring of the trouble-free operation of all its systems. Including excretion systems: urination at the proper level and excretion of feces. If people notice constipation quickly and try to eliminate the discomfort, stagnation of urine may not be detected immediately. In case of problems with urination, diuretics are prescribed. Furosemide is considered one of the effective types of such drugs.

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What is furosemide

This medicine is produced in industrial production. It is presented:

in ampoules for injections;
in tablet form.

For independent use, the doctor prescribes furosemide tablets. Each of them contains 40 mg of active substance. The package contains 50 tablets in contour cells. Dosages for use are prescribed by a specialist.

Urine excretion is carried out due to increased release of sodium ions. The levels of magnesium and calcium ions increase. A distinctive feature of this physiological reaction to the drug is increased excretion of water, which is of the secondary type. There is an increased secretion of potassium ions in the distal part of the renal canal.

Important! The drug promotes the release of intrarenal mediators. The redistribution of intrarenal blood flow formed due to this becomes another factor in urine excretion at an additional level. The drug causes strong, rapid and short-term diuresis.

Furosemide release form

How does the drug work?

The pharmacological group to which furosemide belongs is: strong diuretics. The active ingredient of this product is furosemide.

A distinctive feature of a drug such as furosemide is its duration of action. Active excretion of urine occurs within 1-2 hours after taking the drug and continues for approximately 2-3 hours. After this, the drug is naturally eliminated from the body and ceases its effect on the frequency and volume of urination. When used in a hospital, it is injected into a vein. In this case, the action begins within 5-10 minutes.

During pregnancy and lactation it can be used only on the basis of acute indications. Only one-time use is possible.

Furosemide is a strong diuretic

Indications for use of furosemide

Explains in detail the method of using such a product as furosemide tablets, instructions for use with a detailed description. There are many reasons for urinary retention, or ischuria. These may be inflammatory diseases of the genitourinary system, neurological diseases, or taking certain medications. In men, inflammation of the prostate often leads to such consequences. In women, such a manifestation may lead one to assume inflammation or prolapse of the genital organs. Why urine does not pass well can only be determined by an experienced specialist. Consultation with him is necessary in any situation, and often an experienced doctor prescribes a drug such as furosemide to eliminate the problem.

Clear indications for prescribing include:

situations of diagnosing liver cirrhosis;
establishment of nephrotic syndrome;
cases of chronic insufficiency classified as II and III degrees;
pulmonary or cerebral edema;
eclampsia;
situation of detecting cardiac asthma;
hypercalcemia;
carrying out forced diuresis;
arterial hypertension in the severe stage.

For patients with these diagnoses, Only a specialist can prescribe treatment with the drug. People often decide for themselves whether to take medication. The basis is the assumption that you have edema and the decision to get rid of extra pounds due to the loss of fluid in the body. In each such case, self-prescription can be dangerous. Furosemide is a drug, and use without health reasons can cause harm to the body.

Attention! Trying to get rid of a couple of extra pounds with the help of a diuretic does not actually lead to normalization of body weight. The “poured” excess weight quickly returns with every cup of liquid you drink. The drug contributes to excess load on the excretory systems.

Arterial hypertension is an indication for use

Side effects

Numerous side effects of the drug should dissuade you from attempting self-prescription. The medicine is a type of loop diuretic. Its main task is to disrupt the reabsorption of sodium chloride ions, which in normal situations occurs independently in the thick segment of the ascending part of the loop of Henle. Furosemide increases the excretion of calcium and magnesium ions.

Due to this, the diuretic can lead to the following side effects:

blood pressure may drop;
cases of collapse have been identified, variants of the manifestation of arrhythmia and tachycardia have been noted;
disturbances in the functioning of the central nervous system up to such manifestations as confusion;
the appearance of cramps that constrain the calf muscles with a stone;
noticeable and severe weakness;
decrease in blood volume;
acute urinary retention;
lethargy and drowsiness;
increased risk of thromboembolism;
aplastic anemia;
decreased potency in men;
impairment of normal hearing and decreased or deteriorating vision;
anaphylactic shock;
exacerbation of pancreatitis;
allergic type reactions, the appearance of hives, a visible rash that can itch for a long time;
thrombophlebitis and many other diagnoses

Disruption of the excretory system contributes to exacerbation of virtually any chronic disease, their transition to a severe form. The use of diuretics is possible only with mandatory health monitoring by a specialist. Self-prescription has a negative impact on all organs and systems.

Headache with a strong decrease in blood pressure

What is the dosage of the drug?

The use of furosemide can only be prescribed by a doctor who determines the dose. In medical practice, various dosage options are used, directly depending on the type of diagnosis:

At the initial appointment, when the patient suffers from such an unpleasant type of disease as edema syndrome, if chronic heart failure is detected, specialists prescribe 20-40 mg of the active drug per day. It is recommended in this corridor to select the amount of the product individually for the patient.
If prescribed for edema syndrome that occurs as a result of acute renal failure, as a rule, 40-60 mg per day is prescribed. Treatment may be accompanied by sudden weight loss. Often it loses 2 kg in 24 hours. The dose is taken in one or two doses during the day.
When the patient is on hemodialysis, up to 1500 mg per day may be prescribed.
In case of liver diseases, edema syndrome can be detected. It is recommended to start using 20-80 mg. This option is recommended for use in cases of insufficient effective use of aldosterone antagonists.
For arterial hypertension, a dose of 20-60 mg is used. The dose in this situation falls into the maintenance category. Therapy must be carried out in combination with other hypertensive drugs.

Important! Dosage of medication in most cases determined individually. It is calculated depending on many indicators: age, health status, weight of the person taking the course. The most common option for prescribing medication to a child is 1-2 mg of the drug per 1 kg of body weight, with the exception of taking more than 6 mg per day.

Is it possible to overdose?

In case of excessive use of the drug furosemide, overdose can lead to death. Water and electrolyte balance is constantly monitored. At a dosage of more than 1500 mg per day, renal failure occurs. In case of one-time excess intake, gastric lavage is recommended. If there is a constant excess of intake in small quantities, disturbances in the functioning of internal organs appear. They are signaled by weakness, dry skin and mucous membranes, constant fatigue and drowsiness.

It is important to follow the dosage prescribed by your doctor

Contraindications for therapy

There is a list of conditions for which this drug is not prescribed:

cannot be used in the situation of identifying the fact of stenosis of the urethra;
prohibited for hypokalemia:
not used for renal failure;
use in cases of hepatic precoma and coma is excluded.

Use is not recommended for gout, coma, digitalis intoxication, impaired water-electrolyte metabolism, and many other diagnoses. In total, doctors call at least 30 diseases, preventing the use of the drug.

As you can see, there is an extensive list of contraindications for the drug furosemide. Such a significant list requires a mandatory assessment of the positive impact on the patient’s health against the backdrop of existing prohibitions. Mandatory consultation with the attending physician is required during the entire period of use of furosemide in therapy. This approach is important due to the need to correctly determine the reception. The analysis is performed to evaluate the combination with other medications that need to be taken. For example:

Furosemide reduces the effectiveness of some drugs important for maintaining vital functions, for example, insulin, hypoglycemic drugs.
The diuretic effect is reduced when taken simultaneously with Phenytoin.
Absorption decreases, the level of diuretic effect decreases when taken simultaneously with anti-inflammatory drugs, used in treatment in combination with colisteramine and colistepol.
Interaction with astemizole increases the risk of arrhythmia.
Interaction with cephalosporin antibiotics leads to the risk of increased nephrotoxicity.

Furosemide for high blood pressure

Furosemide. Instructions.

Conclusion

A professional assessment of the risk of interaction with almost any medicine is required. Furosemide is a useful and effective remedy, but it can only be prescribed by a doctor. The appointment is carried out under the constant supervision of a specialist.

In this medical article you can familiarize yourself with the drug Furosemide. The instructions for use will explain in what cases injections or tablets can be taken, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Furosemide, from which you can find out whether the medicine helped in the treatment of edema, arterial hypertension and kidney diseases in adults and children, for which it is also prescribed. The instructions list furosemide analogues, prices of the drug in pharmacies, as well as its use during pregnancy.

Furosemide is a diuretic to relieve edema. Instructions for use prescribe taking 40 mg tablets, injections in injection ampoules in solution to accelerate the removal of water, as well as magnesium and calcium ions from the body.

Release form and composition

The drug Furosemide is available in the form:

Tablets 40 mg.
Granule for the preparation of suspension for oral administration (for use in pediatrics), in 150 ml jars and sachets.
Solution for intravenous and intramuscular administration, in ampoules of 2 ml.

The active substance is Furosemide.

pharmachologic effect

The active component of this medicine has a diuretic effect, enhancing the excretion of water with magnesium and calcium ions from the body. The use of Furosemide for heart failure leads to a rapid decrease in the preload on the heart caused by the dilation of large veins.

The effect of the drug after intravenous administration occurs very quickly - in five to ten minutes, and after oral use - in an hour. The duration of the diuretic effect of Furosemide varies from two to three hours. With reduced kidney function, the therapeutic effect of the drug lasts up to eight hours.

What does Furosemide help with?

Indications for use of the drug include edema syndrome of various origins, including conditions with:

Liver cirrhosis (portal hypertension syndrome).
Chronic heart failure stage II-III.
Nephrotic syndrome.

In addition, Furosemide according to the instructions is used for:

Some forms of hypertensive crisis.
Eclampsia.
Cardiac asthma.
Pulmonary edema.
Hypercalcemia.
Brain edema.
Carrying out forced diuresis.
Severe arterial hypertension.

Instructions for use

Furosemide tablets are taken orally, without chewing, swallowing immediately, with a small amount of water. The dose of the drug is determined by the doctor individually for each patient, depending on body weight, the severity of edema, and the presence of concomitant diseases.

The drug is prescribed in the minimum effective dosage, starting from 20 mg per day for an adult. If the therapeutic effect is insufficient, the dose of the drug is increased gradually, the maximum daily dose for an adult is 1.5 g.

A time interval of at least 6 hours should be maintained between doses of the drug. If necessary, treatment with Furosemide can be combined with antihypertensive drugs.

Dosage regimen for adults

Edema syndrome in chronic heart failure

The initial dose is 20-80 mg per day. The required dose is selected depending on the diuretic response. It is recommended to divide the daily dose into 2-3 doses.

Edema syndrome in chronic renal failure

In patients with chronic renal failure, careful selection of the dose is required, by gradually increasing it so that fluid loss occurs gradually (at the beginning of treatment, fluid loss of up to approximately 2 kg of body weight per day is possible).

The recommended starting dose is 40-80 mg per day. The required dose is selected depending on the diuretic response. The entire daily dose should be taken once or divided into two doses. In patients on hemodialysis, the usual maintenance dose is 250-1500 mg per day.

Edema in nephrotic syndrome

The initial dose is 40-80 mg per day. The required dose is selected depending on the diuretic response. The daily dose can be taken at one time or divided into several doses.

Edema syndrome in liver diseases

Furosemide is prescribed in addition to treatment with aldosterone antagonists if they are insufficiently effective. To prevent the development of complications, such as impaired orthostatic regulation of blood circulation or disturbances in electrolyte or acid-base status, careful selection of the dose is required so that fluid loss occurs gradually (at the beginning of treatment, fluid loss of up to approximately 0.5 kg of body weight per day is possible). The initial dose is 20-80 mg per day.

Arterial hypertension

Furosemide can be used in monotherapy or in combination with other antihypertensive drugs. The usual maintenance dose is 20-40 mg per day. When adding furosemide to already prescribed medications, their dose should be reduced by 2 times. In case of arterial hypertension in combination with chronic renal failure, higher doses of the drug may be required.

Injection

For intravenous or intramuscular injection of the drug, the recommended dose for adult patients is 20-40 mg per day. In rare cases, it is possible to increase the dosage by 2 times, which are administered twice a day. The recommended dosage for children is 1 mg per kilogram of body weight.

Contraindications

The drug is not prescribed for:

Relative contraindications to the use of Furosemide:

obliterating cerebral atherosclerosis;
hypoproteinemia (taking the drug increases the risk of developing ototoxicity);
hypoproteinemia against the background of nephrotic syndrome (possibly increasing the undesirable side effects of Furosemide (especially ototoxicity) and reducing its effectiveness);
benign prostatic hyperplasia (BPH);
hepatorenal syndrome;
hypotension in patients at risk of ischemia (coronary, cerebral or other), which is associated with circulatory failure;
diabetes.

Side effects

Furosemide may cause the following side effects:

Sense organs: hearing and vision impairment.
Hematopoietic system: aplastic anemia, agranulocytosis, leukopenia and thrombocytopenia.
Water-electrolyte metabolism: hypomagnesemia, hyponatremia, hypovolemia, metabolic alkalosis, hypocalcemia, hypochloremia, hypokalemia.
Metabolism: hyperglycemia, muscle weakness, cramps, hypotension, hyperuricemia and dizziness.
Genitourinary system: hematuria, interstitial nephritis, acute urinary retention, decreased potency.
Nervous system: drowsiness, myasthenia gravis, apathy, weakness, lethargy, confusion, calf muscle cramps, headache, paresthesia, adynamia.
Gastrointestinal tract: dry mouth, nausea, exacerbation of pancreatitis, thirst, vomiting, decreased appetite, diarrhea or constipation and cholestatic jaundice.
Allergic reactions: erythema multiforme exudative, photosensitivity, pruritus, exfoliative dermatitis, urticaria, vasculitis, purpura, fever, chills, necrotizing angitis and anaphylactic shock.
Cardiovascular system: decreased blood pressure, arrhythmia, tachycardia, orthostatic hypotension, collapse.

Children, pregnancy and breastfeeding

The medicine crosses the placental barrier, so it should not be prescribed during pregnancy. If it is necessary to prescribe Furosemide during pregnancy, the ratio of the benefits of using the drug for the mother to the risk for the fetus should be assessed. Excreted in breast milk. If treatment with the drug is necessary, breastfeeding should be stopped.

The drug is contraindicated in children under 3 years of age. A children's single dose of Furosemide is calculated based on body weight and is 1-2 mg per 1 kg, but not more than 6 mg/kg.

special instructions

Before starting treatment, you should ensure that the urinary system is functioning normally and that there is no obstruction in the outflow of urine. Patients undergoing treatment with Furosemide require periodic monitoring of blood pressure, uric acid, plasma electrolytes, creatinine, renal and liver function, and glucose levels.

While taking the drug, you should avoid driving a vehicle and operating complex mechanisms that require increased concentration and reaction speed. A solution for intravenous or intramuscular administration cannot be mixed in the same syringe with other drugs.

Drug interactions

Some drugs in combination with Furosemide cause undesirable reactions, which must be taken into account when carrying out therapy.

The drug cannot be combined with medications such as: aminoglycosides, cephalosporins, insulin and hypoglycemic drugs, phenytoin, beta-agonists, indomethacin, non-steroidal anti-inflammatory drugs, ACE inhibitors, astemizole, colestipol, cholestyramine, digitoxin, digoxin, lithium carbonate, cisapride and cisplatin .

Analogues of the drug Furosemide

Analogues are determined by structure:

Fursemid.
Lasix.
Furon.
Furosemide Lannacher (Mifar, Sopharma, -Vial, -Darnitsa, -ratiopharm, -Ferein).
Furosemide solution for injection 1%.

Vacation conditions and price

The average price of Furosemide (40 mg tablets No. 50) in Moscow is 25 rubles.

According to indications, the medicine is dispensed from pharmacies according to medical prescription, according to a prescription. Shelf life is up to three years.

The drug Furosemide is an effective fast-acting diuretic used for excess fluid accumulation in the organs of the urinary system, as a diuretic for edema, etc. Let's take a closer look at the drug Furosemide - what it is prescribed for, how the tablets or solution work and how effective they are.

Characteristics of the product

The drug is available both in the form of tablets and in the form of a solution for injection. The speed at which the first positive results of treatment with Furosemide appear depends on the use of a particular dosage form of the drug. So, when administered intravenously, it can quickly cause the desired effect and has a diuretic effect after 15 minutes, when using the tablet form - after half an hour. The effect lasts for quite a long time, up to four hours.

For Furosemide, the indications for use are quite extensive. This medicine is prescribed for diseases such as hypertension, renal and heart failure, nephrotic syndrome, as well as for serious liver disorders (for example, cirrhosis).

Furosemide is also often chosen for cystitis. Unlike many drugs of similar action, it does not reduce glomerular filtration. This allows it to be used in cases of renal failure. The hypotensive effect of the drug expands the scope of its application.

However, this drug may not always be prescribed. Contraindications for Furosemide may include:

The drug must be prescribed by a doctor who first explains how to take Furosemide correctly and how to respond to possible side effects. If symptoms such as nausea, vomiting, attacks of thirst, dizziness, or diarrhea occur, you should immediately inform your doctor. Usually in this case the dosage of the drug is reduced, or Furosemide is replaced with another drug. In addition to those listed, side effects such as various allergic reactions, general weakness, etc. may occur.

As a rule, Furosemide for edema is prescribed in a dosage of 40 mg per day, for which the method of administration is determined - 1 tablet per day in the morning. The dosage can be doubled and divided into two doses with an interval of 6 hours (for the first half of the day). After the swelling decreases, the dosage of the drug is gradually reduced, the interval between applications increases. For children, the dosage is calculated depending on body weight, namely 1-2 mg of medication per kilogram of weight.

Use of Furosemide for cystitis

In order to understand why Furosemide is prescribed for cystitis, you need to know what this disease is. Cystitis is an inflammatory process that occurs in the bladder, which is of a bacterial nature and primarily affects the mucous membrane of the organ. The causative agents of cystitis are Escherichia coli and Pseudomonas aeruginosa bacteria, staphylococcus and Candida fungi. Once in the bladder, these microorganisms begin to actively multiply, resulting in disruption of the functioning of this organ.

Cystitis, as an indication for the use of Furosemide, is considered because the inflammatory process occurring in the bladder requires the prevention of stagnation of urine, as a condition for its development. Unfortunately, most often cystitis becomes chronic due to the patient’s incorrect approach to treatment. Often, the patient independently chooses medications and methods of therapy, uses traditional medicine, and determines when to stop treatment. In this case, little attention is usually paid to establishing the process of excreting urine in a sufficient volume, and this has a direct impact on suppressing the source of inflammation in the organs of the urinary system in general and the bladder in particular.

Typically, during the treatment of cystitis, doctors recommend that patients drink as much fluid as possible, while prescribing various diuretics. Furosemide for cystitis is prescribed precisely in this capacity. This approach ensures the regular outflow of large volumes of urine, which leads to a decrease in inflammation and signs of intoxication.

However, Furosemide for cystitis cannot be the only drug or form the basis of therapy. It must be remembered that bacterial inflammation requires the use of antibiotics or at least drugs based on medicinal herbs with antiseptic action, if we are talking about the initial stage of the disease. In the absence of proper treatment, the disease will progress, and in addition to the discomfort when urinating, with which it all began, symptoms such as:

If the symptomatic picture is supplemented with the above signs, the patient will be indicated for hospitalization and long-term treatment. Otherwise, the patient’s condition will worsen even more, and the disease will lead to serious complications.

Furosemide for edema

If Furosemide is prescribed for cystitis to stimulate the excretion of urine and increase the volume of circulating fluid, then for edema it is used to remove excess fluid from the body. In this case, the patient is usually advised, on the contrary, to reduce the amount of water consumed.

It is very important to maintain a balance in the process of water-salt metabolism. The fluid consumed and output must be equivalent in volume. Otherwise, excess fluid will accumulate in the body. If it begins to be deposited in tissues and cavities, a person may not notice it at first. Only external swelling that forms on the face, limbs, etc. become noticeable immediately.

Edema occurs due to a number of diseases and dysfunctions. For example, due to allergies, liver diseases, due to the use of certain medications. In any case, excess fluid must be removed from the body. In the absence of contraindications, Furosemide can be used for edema.

In this case, it is usually prescribed in a standard dosage - 1 tablet per day (in the morning) every day, as swelling decreases, once every two or three days, until complete cessation of use.

It is noted that a person who has taken the drug once already notices some reduction in swelling, and after a few days they, in most cases, go away completely.

Of course, in this case it is necessary to take other measures, primarily aimed at eliminating the causes that caused the appearance of swelling. If the disease that provoked the formation of edema is not cured, then this symptom will return again after stopping Furosemide. Meanwhile, this drug should not be abused. It must be used according to the schedule established by the attending physician and only after a prescription has been made.

You should be aware that uncontrolled use of diuretics, including Furosemide, can lead to very serious consequences. In addition, with the fluid removed from the body, especially in large volumes, many useful elements are washed out, such as magnesium, calcium, potassium, sodium, etc. If the drug is prescribed by a doctor, he gives recommendations for correcting nutrition or prescribes vitamin and mineral complexes.

If for some reason the use of diuretics is impossible, for example, the maximum permissible duration of the course of taking Furosemide has been exceeded, you can use other methods of relieving edema. For example, a light stroking massage, foot baths, and rest help a lot in this case. You can consult with a specialist who can offer additional options for eliminating this symptom.

Any changes in the patient’s condition and therapy for swelling should be monitored by the attending physician, since self-medication can lead to an imbalance in the water balance in the body, which in itself is very dangerous.

Name:

Furosemide (Furosemiduin)

Pharmacological
action:

Fast acting diuretic(saluretic) - a diuretic that enhances the excretion of sodium and chlorine. The diuretic (diuretic) effect is associated with inhibition of reabsorption (reabsorption) of Na and C1 ions in both the proximal (located in the central part of the kidney) and distal (located on the periphery of the kidney) sections of the convoluted tubules and in the ascending parts of the loop of Henle. Potassium reabsorption is inhibited to a lesser extent. The drug is equally effective in conditions of acidosis (acidification) and alkalosis (dehydration) of the blood. Furosemide does not reduce glomerular filtration, and therefore it can be used in renal failure. Due to the dilation of peripheral blood vessels and the diuretic effect, the drug has a hypotensive (lowering blood pressure) effect.
When administered intravenously the diuretic effect is observed after 15-20 minutes and lasts for 3 hours, when taken orally - after 30-50 minutes, lasts up to 4 hours.

Indications for
application:

Congestion in the pulmonary and systemic circulation associated with heart failure; liver cirrhosis with portal hypertension (increased pressure in the liver portal vein system), chronic and acute renal failure, pulmonary and cerebral edema, barbiturate poisoning, eclampsia (late toxicosis of pregnancy).
Furosemide is indicated for patients with severe forms of hypertension (persistent increase in blood pressure), in which other diuretics are not effective, as well as for relieving (relieving) severe hypertensive crises (rapid and sharp rise in blood pressure).

– edematous syndrome of various origins, incl. for chronic heart failure stages IIB-III, liver cirrhosis (portal hypertension syndrome), nephrotic syndrome;
- pulmonary edema;
– post-traumatic cerebral edema;
– some forms of hypertensive crisis;
– eclampsia;
– premenstrual tension syndrome;
– program of forced diuresis for barbiturate poisoning.

Mode of application:

Prescribed orally, intramuscularly or intravenously.
Inside Usually take 40 mg 1 time per day (in the morning). If necessary, the daily dose can be increased to 80-160 mg; in this case, the drug is taken 1-2 times a day. day with an interval of 6 hours.
For severe renal failure the dose can be increased to 240-320 mg/day. After swelling decreases, the dose is gradually reduced to the minimum effective, and the intervals between doses are increased to 1-2 days. For hypertension, furosemide Prescribe 20-40 mg 1 time per day; when combined with heart failure, the dose can be increased to 80 mg.
If it is impossible or impractical to prescribe furosemide orally, the drug is administered intramuscularly or intravenously(slow stream) 20-60 mg 1-2 times a day, if necessary, the dose can be increased to 120 mg. The drug is administered for 7-10 days or more. Then they switch to taking the drug orally.
For children a single dose of the drug is 1-2 mg/kg; the maximum daily dose is 6 mg/kg.

Side effects:

From the side of water-electrolyte balance and acid-base balance: with long-term use or prescription in high doses - hypovolemia, dehydration, hypokalemia, hyponatremia, hypochloremia, alkalosis; in some cases - hypocalcemia.
From the cardiovascular system: arterial hypotension, heart rhythm disturbances.
From the side of the central nervous system: dizziness, muscle weakness, cramps; in some cases, when using the drug in high doses in patients with severe impairment of renal excretory function - hearing impairment, vision impairment, paresthesia.
From the digestive system: dry mouth; rarely - nausea, vomiting, diarrhea.
Metabolism: transient hyperuricemia (with exacerbation of gout), increased levels of urea and creatinine; in some cases - hyperglycemia.
Dermatological reactions: dermatitis.
Others: in some cases - anaphylactic shock, changes in the peripheral blood picture.

Contraindications:

– renal failure with anuria;
– hepatic coma and precoma;
– disorders of water-salt metabolism: hypokalemia, hyponatremia, hypovolemia (including with hypotension) or dehydration;
– I and II trimesters of pregnancy;
– hypersensitivity to sulfonamides.

special instructions
Prescribe the drug with caution when severe cardiovascular failure, with prolonged therapy with cardiac glycosides, as well as in elderly patients with severe atherosclerosis. Before starting treatment, serious disturbances in water and electrolyte balance should be compensated.
Control of laboratory parameters
During treatment, electrolyte levels should be regularly monitored. carbonates, urea (especially when using doses above 80 mg).
Impact on the ability to drive vehicles and control of mechanisms
The question of the possibility of engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions should be decided after assessing the patient’s individual reaction, due to a possible decrease in the ability to concentrate.

Interaction
other medicinal
by other means:

with cardiac glycosides the risk of developing glycoside intoxication increases, and when used in combination with GCS, the risk of developing hypokalemia.
With simultaneous use, Furosemide potentiates the effect muscle relaxants.
With simultaneous use of Furosemide with aminoglycosides or cephalosporins and cisplatin, it is possible to increase their concentration in the blood plasma, which can lead to the development of nephro- and ototoxic effects.
When used simultaneously NSAIDs may reduce the diuretic effect of Furosemide.
With the simultaneous use of Furosemide and antihypertensive drugs the hypotensive effect is potentiated.
When used simultaneously with Furosemide, the effect hypoglycemic drugs and pressor amines may be weakened.

Furosemide is a fast-acting diuretic used to combat swelling of the respiratory system and brain, as well as disorders of the systemic circulation. It is distinguished by its rapid diuretic effect on the body.

As an active ingredient, the drug contains furosemide in a dosage of 40 mg. The original drug is Lasix, developed by Sanofi. Furosemide is one of the most powerful diuretics, and it is effective in both oral and parenteral forms.

The therapeutic effect is observed within 5-10 minutes if the drug is used in the form of a solution for intravenous injection. When using a tablet formulation, the therapeutic effect is achieved within the first hour.

Clinical and pharmacological group

Diuretic.

Terms of sale from pharmacies

Can buy according to a doctor's prescription.

Price

How much does Furosemide cost in pharmacies? The average price is 25 rubles.

Composition and release form

Tablets: flat-cylindrical, round, chamfered, white with a brownish or yellowish tint, 10 pieces in a blister pack made of polyvinyl chloride film and polymer-coated paper or aluminum foil. 1, 2, 3 or 5 blisters in a cardboard box, 50 tablets in a dark glass jar of the BTS type or a polymer jar of the BP type, with a plastic pull-on lid. 1 can in a cardboard box.

Composition of the tablet:

active substance: furosemide – 40 mg;
auxiliary components: lactose monohydrate, potato starch, calcium stearate monohydrate.

Pharmacological effect

The active component Furosemide has a diuretic effect, promoting increased excretion of water while simultaneously increasing the excretion of calcium and magnesium ions.

When Furosemide is used against the background of heart failure, a rapid decrease in preload on the heart occurs, caused by the dilation of large veins. After intravenous administration, the effect of Furosemide occurs quickly - within 5-10 minutes, after oral administration - on average within an hour.

The duration of the diuretic effect from taking Furosemide is two to three hours, and with reduced renal function, the effect of the drug can last up to eight hours.

Indications for use

What does it help with? Furosemide confidently copes with edema of various origins, so its range of use is very wide. It is prescribed for the following problems:

edema, the causes of which are kidney pathologies (including nephrotic syndrome), stage II-III CHF or cirrhosis of the liver;
manifested as pulmonary edema of acute heart failure;
hypertensive crisis (as monotherapy or in combination with other drugs);
severe forms of arterial hypertension;
cerebral edema;
hypercalcemia;
eclampsia.

The drug is also used for forced diuresis in case of poisoning with chemicals that are excreted from the body unchanged by the kidneys.

With elevated blood pressure developing against the background of chronic renal failure, furosemide is prescribed if the patient is contraindicated in thiazide diuretics, and also if Clcr does not exceed 30 ml per minute).

Can Furosemide be used for weight loss?

There is a lot of advice on the Internet regarding the use of diuretics for weight loss. One of the most accessible drugs in this group is Furosemide.

What does the medicine help with? According to the instructions, Furosemide is used for ascites, edema syndrome, and hypertension. Thus, the manufacturer does not report anything regarding the possibility of using diet pills. However, many women note that with the help of this remedy they were able to quickly lose several kilograms (in some cases, up to 3 kg per night). However, such weight loss cannot be regarded as weight loss: the action of the drug is aimed at removing excess fluid, and not at all at breaking down fat.

Why is Furosemide dangerous?

The use of diuretics for weight loss can cause serious health problems, since by removing water, these drugs also upset the balance of electrolytes in the body. One of the most common side effects is hypokalemia. Potassium deficiency, in turn, leads to muscle cramps, weakness, blurred vision, sweating, loss of appetite, nausea, and dizziness.

A very dangerous side effect is arrhythmia. SOLVD studies have shown that treatment with loop diuretics is associated with increased mortality among patients. At the same time, both the rates of general and cardiovascular mortality and the number of sudden deaths are increasing. Another danger that can result from the uncontrolled use of diuretics for weight loss is impaired kidney function. Moreover, it may take more than one month to restore the function of the kidneys and lymphatic system.

Contraindications

Absolute contraindications:

hyperuricemia;
increased central venous pressure (over 10 mm Hg);
idiopathic hypertrophic subaortic stenosis;
hepatic coma and precoma;
decompensated mitral or aortic stenosis;
disturbances in the outflow of urine of any etiology (including unilateral damage to the urinary tract);
severe liver failure;
acute glomerulonephritis;
acute renal failure with anuria (glomerular filtration rate less than 3–5 ml/min);
disturbance of water-electrolyte metabolism, as well as acid-base balance (alkalosis, hypokalemia, hypovolemia, hyponatremia, hypomagnesemia, hypocalcemia, hypochloremia);
digitalis intoxication;
increased sensitivity to any of the components of the drug.

Additionally for tablets:

acute myocardial infarction;
pancreatitis;
dehydration;
galactose intolerance;
precomatose states;
hyperglycemic coma;
hypertrophic obstructive cardiomyopathy;
arterial hypotension;
glucose-galactose malabsorption or lactase deficiency;
age up to 3 years.

Patients with allergies to sulfonylureas or sulfonamide antimicrobials are at risk of developing cross-allergy to Furosemide.

Relative contraindications:

history of ventricular arrhythmia;
hypoproteinemia (risk of developing ototoxicity);
diarrhea;
hearing loss;
systemic lupus erythematosus;
arterial hypotension - in the presence of conditions in which an excessive decrease in blood pressure can be especially dangerous (stenotic lesions of the coronary or cerebral arteries);
acute myocardial infarction (due to an increased risk of developing cardiogenic shock);
manifested or latent diabetes mellitus (decreased glucose tolerance);
hepatorenal syndrome;
disturbances in the outflow of urine (hydronephrosis, narrowing of the urethra, benign prostatic hyperplasia);
gout;
prematurity in children (due to the risk of the formation of calcium-containing kidney stones and the deposition of calcium salts in the kidney parenchyma, constant monitoring of kidney function and regular ultrasound examination of the kidneys are necessary).

Additionally for tablets: stenotic lesions of the coronary or cerebral arteries.

Prescription during pregnancy and lactation

Excreted in breast milk. If treatment with the drug is necessary, breastfeeding should be stopped.

Dosage and method of administration

As indicated in the instructions for use, Furosemide tablets should be taken on an empty stomach, without chewing and with a sufficient amount of liquid.

When prescribing Furosemide, it is recommended to use the smallest doses sufficient to achieve the desired effect. The maximum daily dose for adults is 1500 mg. The initial single dose in children is determined at the rate of 1-2 mg/kg body weight/day with a possible increase in the dose to a maximum of 6 mg/kg/day, provided the drug is taken no more often than every 6 hours. The duration of treatment is determined by the doctor individually, depending from the testimony.

Dosage regimen for adults:

. Furosemide can be used in monotherapy or in combination with other antihypertensive drugs. The usual maintenance dose is 20-40 mg/day. When adding furosemide to already prescribed medications, their dose should be reduced by 2 times. In case of arterial hypertension in combination with chronic renal failure, higher doses of the drug may be required.
Edema in nephrotic syndrome. The initial dose is 40-80 mg/day. The required dose is selected depending on the diuretic response. The daily dose can be taken at one time or divided into several doses.
Edema syndrome in chronic heart failure. The initial dose is 20-80 mg/day. The required dose is selected depending on the diuretic response. It is recommended to divide the daily dose into 2-3 doses.
Edema syndrome in chronic renal failure. In patients with chronic renal failure, careful selection of the dose is required, by gradually increasing it so that fluid loss occurs gradually (at the beginning of treatment, fluid loss of up to approximately 2 kg of body weight / day is possible). The recommended initial dose is 40-80 mg/day. The required dose is selected depending on the diuretic response. The entire daily dose should be taken once or divided into two doses. In patients on hemodialysis, the maintenance dose is usually 250-1500 mg/day.
Edema syndrome in liver diseases. Furosemide is prescribed in addition to treatment with aldosterone antagonists if they are insufficiently effective. To prevent the development of complications, such as impaired orthostatic regulation of blood circulation or disturbances in electrolyte or acid-base status, careful dose selection is required so that fluid loss occurs gradually (at the beginning of treatment, fluid loss of up to approximately 0.5 kg of body weight/day is possible). The initial dose is 20-80 mg/day.

Adverse reactions

Furosemide may cause the following side effects:.

Hematopoietic system: aplastic anemia, agranulocytosis, leukopenia and thrombocytopenia.
Water-electrolyte metabolism: hypomagnesemia, hyponatremia, hypovolemia, metabolic alkalosis, hypocalcemia, hypochloremia, hypokalemia.
Metabolism: hyperglycemia, muscle weakness, cramps, hypotension, hyperuricemia and dizziness.
Cardiovascular system: decreased blood pressure, arrhythmia, tachycardia, orthostatic hypotension, collapse.
Nervous system: drowsiness, myasthenia gravis, apathy, weakness, lethargy, confusion, calf muscle cramps, headache, paresthesia, adynamia.
Sense organs: hearing and vision impairment.
Gastrointestinal tract: dry mouth, nausea, exacerbation of pancreatitis, thirst, vomiting, decreased appetite, diarrhea or constipation and cholestatic jaundice.
Genitourinary system: hematuria, interstitial nephritis, acute urinary retention, decreased potency
Allergic reactions: erythema multiforme exudative, photosensitivity, pruritus, exfoliative dermatitis, urticaria, vasculitis, purpura, fever, chills, necrotizing angitis and anaphylactic shock.

Overdose

If the recommended dose is exceeded or prolonged uncontrolled use of Furosemide, patients develop signs of overdose, which are clinically manifested by increased side effects described above, paralysis, respiratory depression, cardiovascular depression, development of coma, acute renal failure and shock.

Treatment of overdose consists of correcting the water-electrolyte balance through diffuse infusions of isotonic sodium chloride solution, gastric lavage, replenishment of circulating blood volume, and symptomatic treatment.

special instructions

Before you start using the drug, read the special instructions:

The use of furosemide slows down the excretion of uric acid, which can provoke an exacerbation of gout.
Patients with hypersensitivity to sulfonamides and sulfonylureas may have cross-sensitivity to furosemide.
If azotemia and oliguria appear or worsen in patients with severe progressive kidney disease, it is recommended to suspend treatment.
In patients with diabetes mellitus or with reduced glucose tolerance, periodic monitoring of the level of glucose concentration in the blood and urine is required.
In unconscious patients with benign prostatic hyperplasia, narrowing of the ureters or hydronephrosis, monitoring of urinary output is necessary due to the possibility of acute urinary retention.
This medicine contains lactose monohydrate, therefore patients with rare hereditary problems of galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
The drug contains wheat starch in an amount that is safe for use in patients with celiac disease (gluten enteropathy).
Patients with a wheat allergy (other than celiac disease) should not use this drug.

Before starting therapy with Furosemide Sopharma, the presence of severe disturbances in the outflow of urine should be excluded; patients with partial disturbances in the outflow of urine require careful monitoring. During the course of treatment, it is necessary to periodically monitor blood pressure, the content of blood plasma electrolytes (including sodium, calcium, potassium, magnesium ions), acid-base status, residual nitrogen, creatinine, uric acid, liver function and, if necessary, carry out appropriate treatment adjustment.

In patients receiving high doses of furosemide, in order to avoid the development of hyponatremia and metabolic alkalosis, it is not advisable to limit the consumption of table salt. To prevent hypokalemia, it is recommended to simultaneously administer potassium supplements and potassium-sparing diuretics, as well as adhere to a diet rich in potassium. The selection of a dosage regimen for patients with ascites against the background of liver cirrhosis should be carried out in a hospital setting (disturbances in water and electrolyte balance can lead to the development of hepatic coma). This category of patients requires regular monitoring of plasma electrolyte levels.

Compatibility with other drugs

When using the drug, it is necessary to take into account interactions with other medications:

Furosemide may increase the risk of nephropathy after administration of radiocontrast agents.
The combination of the drug with cardiac glycosides increases the risk of developing digitalis intoxication.
The effect of Furosemide is reduced when used simultaneously with phenobarbital and phenytoin.
The drug is able to increase the concentration of cephalosporin antibiotics and chloramphenicol. At the same time, it increases the risk of developing their nephro- and ototoxic effects. The elimination of aminoglycoside antibiotics slows down when they are combined with Furosemide, which also increases the likelihood of intoxication.
Elderly patients often have to take Furosemide and drugs from the group of non-steroidal anti-inflammatory drugs. You should be careful with this combination, as it leads to a decrease in the effectiveness of Furosemide. If salicylates are chosen as NSAIDs, Furosemide may enhance their toxic effect.
A weakening of the effect of Furosemide is observed when taken simultaneously with sucralfate. Increased activity - when combined with other diuretics or antihypertensive drugs, especially ACE inhibitors.