Osteogenon: instructions for use and what it is needed for, price, reviews, analogues. A drug for normalizing phosphorus-calcium metabolism - Osteogenon Osteogenon instructions for use reviews

In this article you can read the instructions for use of the drug Osteogenon. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Osteogenon in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Osteogenon in the presence of existing structural analogues. Use for the treatment of osteoporosis and accelerating the healing of bone fractures in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Osteogenon- a drug that affects bone mineralization (regulator of calcium-phosphorus metabolism).

Osteogenon contains components necessary for the synthesis of bone tissue and has a dual effect on bone metabolism: it stimulates osteoblasts and inhibits osteoclasts.

Calcium is contained in the drug in the form of hydroxyapatite (in a 2:1 ratio with phosphorus), which promotes more complete absorption from the gastrointestinal tract. Inhibits the production of parathyroid hormone and prevents hormonally caused bone resorption. The slow release of calcium from hydroxyapatite results in the absence of a hypercalcemia peak.

Phosphorus, which participates in the crystallization of hydroxyapatite, promotes the fixation of calcium in the bone and inhibits its excretion by the kidneys.

Ossein is an organic component of the drug that contains local regulators of bone tissue remodeling (beta-transforming growth factor, insulin-like growth factors 1 and 2, osteocalcin, collagen type 1), which activate the process of bone formation and inhibit bone resorption.

Transforming growth factor beta stimulates the activity of osteoblasts, increases their number, promotes collagen production, and also inhibits the formation of osteoclast precursors.

Insulin-like growth factors 1 and 2 stimulate the synthesis of collagen and osteocalcin.

Osteocalcin promotes the crystallization of bone tissue by binding calcium.

Type 1 collagen ensures the formation of bone matrix.

Compound

Ossein-hydroxyapatite compound + excipients.

Indications

prevention and treatment of primary osteoporosis of various etiologies (premenopausal, menopausal, senile);
prevention and treatment of secondary osteoporosis of various etiologies (caused by rheumatoid arthritis, liver and kidney diseases, hyperthyroidism, hyperparathyroidism, imperfect bone formation, use of corticosteroids, heparin, immobilization);
correction of osteopenia and disorders of phosphorus-calcium metabolism (including during pregnancy and breastfeeding);
accelerating the healing of bone fractures.

Release forms

Film-coated tablets 830 mg.

Instructions for use and dosage regimen

The duration of treatment is determined by the patient's condition.

Side effect

allergic reactions;
hypercalcemia;
hypercalciuria.

Contraindications

severe renal failure;
hemodialysis;
severe hypercalciuria;
childhood;
hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

Osteogenon can be used during pregnancy and breastfeeding according to indications after consulting a doctor.

Use in children

The drug Osteogenon is contraindicated in childhood.

special instructions

In patients predisposed to urolithiasis, adjustment of the drug dosage regimen may be required depending on laboratory parameters.

In patients with impaired renal function, long-term use of high doses of the drug should be avoided.

The drug contains only trace amounts of sodium chloride, so the use of Osteogenon in patients with arterial hypertension is acceptable.

Drug interactions

Osteogenon slows down the absorption of iron supplements, bisphosphonates and tetracycline antibiotics, therefore, when used simultaneously with these drugs, the time interval between their administration should be at least 4 hours.

When using Osteogenon simultaneously with vitamin D or thiazide diuretics, the doctor should assess the risk of developing hypercalcemia due to increased calcium resorption.

Analogues of the drug Osteogenon

The drug Osteogenon has no structural analogues for the active substance. The drug contains a unique active ingredient in its composition.

Analogs for therapeutic effect (drugs for the treatment of osteoporosis):

Additive calcium;
Aquadetrim;
Aklasta;
Andriol;
Arthromax;
Bivalos;
Bonviva;
Bora Bora;
Vectrum calcium;
Veprena;
Vitabs Calcium;
Vitamin D3 Bon;
Calcemin;
Calcemin Advance;
Calcium D3 Nycomed;
Calcium D3 Nycomed Forte;
CalciumOsteon;
Kidron Willow;
Xydiphone;
Lysite (L-Lysine);
Methandrostenolone;
Miacalcic;
OrthoOsteo;
Ossin;
Ostalon;
Ostalon Calcium D;
Osteocare solution;
Osteopan;
Osteotriol;
Osteochin;
Rezoscan;
Retabolil;
Sustanon 250;
Tilcotil;
Tobitil;
Tridin;
Upsavit Calcium;
Forosa;
Forsteo;
Fosavance;
Fosamax;
Ergocalciferol;
Ergocalciferol (Vitamin D2);
Etalfa.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Osteogenon regulates metabolism in bone tissue, replenishes calcium deficiency and promotes accelerated regeneration. Available in tablet form.

Composition and active ingredient of the drug

The main active component of the drug: an active ossein-hydroxyapatite compound, including the following substances:

Calcium;
Peptides;
Collagen;
Phosphorus;
Non-collagen proteins;
Calcium hydroxyapatite;
Other organic compounds and trace elements.

Indications and principle of action

Osteogenon acts comprehensively and promotes the regeneration of bone and cartilage tissue. With the help of phosphorus, substances necessary for bone tissue growth begin to form in the right place. At the same time, the production of calcium by the kidneys is reduced so that the body has enough material for full tissue repair.

Indications for use:

Cracks and fractures of bones. Prescribed during rehabilitation for accelerated fusion.
In case of osteopenia, an imbalance of calcium and phosphorus in the body during pregnancy.
Osteoporosis caused by inactivity or hyperthyroidism or arthritis.

Contraindications:

Children under 18 years of age;
Kidney failure;
Hypercalciuria;
Individual intolerance to the components of the drug;
Carrying out hemodialysis.

Is it possible to drink Osteogenon with alcohol?

Drinking alcohol in adequate quantities is possible together with Osteogenon and does not lead to the development of incompatibility or intolerance to the drug. The drug is not prescribed or prescribed with caution in case of impaired renal function and urolithiasis. If you have these diseases, you should avoid drinking alcohol and consult your doctor about possible side effects of the medication.

Important: Despite the fact that there are no direct contraindications for using Osteogenon with alcohol, you should remember the increased risk of developing hypercalcemia with long-term use of the drug along with alcohol abuse.

Each film-coated tablet contains:

Active ingredient: ossein-hydroxyapatite compound (OHC) - 830.00 mg (refers to dry substance).

The main component of the inorganic part of OGS is calcium phosphate in the form of microcrystalline hydroxyapatite, embedded in the protein matrix. Ossein consists mainly of collagenous and non-collagenous peptides/proteins.

Other components: microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, potato starch, hydroxypropyl methylcellulose, titanium dioxide (E171), polyethylene glycol, talc, yellow iron oxide (E172).

Description

film-coated tablets, light yellow, evenly colored, oblong, with biconvex surfaces. Length: ~18.2 mm, width: ~8.7 mm, thickness ~6.2 mm.

pharmachologic effect

Osteogenon has a dual effect on bone metabolism: a stimulating effect on osteoblasts and an inhibitory effect on osteoclasts. Osteogenon contains all the necessary components for the synthesis of bone tissue.

Calcium, which is part of the drug, is contained in it in the form of hydroxyapatite (in a 2:1 ratio with phosphorus), which promotes more complete absorption in the gastrointestinal tract: in addition, it inhibits the production of parahormone and prevents hormonally caused resorption of bone tissue. The slow release of calcium from hydroxyapatite results in the absence of a hypercalcemia peak. Phosphorus, which participates in the crystallization of hydroxyapatite, promotes the fixation of calcium in the bone and inhibits its excretion by the kidneys.

Indications for use

Calcium deficiency, especially during growth, pregnancy, lactation;

An additional method of treating osteoporosis, including primary and secondary (senile, postmenopausal, corticosteroid, immobilization during restoration of mobility).

Contraindications

Hypersensitivity to any component;

In patients with severe renal failure and patients on hemodialysis;

Hypercalcemia, hypercalciuria, calcium stone formation, tissue calcification;

Prolonged immobilization accompanied by hypercalcemia and/or hypercalciuria: when treating with calcium, attention should be paid to restoring mobility;

Children under 6 years of age due to the dosage form.

Directions for use and doses

For oral administration.

The tablets should be swallowed with a full glass of water.

Adults and children over 6 years of age:

1-2 tablets per day, corresponding to 178-356 mg elemental calcium/day and 82-164 mg elemental phosphorus/day.

For osteoporosis:

2-4 tablets 2 times a day, corresponding to 356-712 mg elemental calcium/day and 164-328 mg elemental phosphorus/day.

The duration of treatment is determined by the patient's condition.

Side effect

In rare cases, allergic reactions may occur. Hypercalcemia and hypercalciuria in case of long-term use.

Overdose

Feeling of thirst, polyuria, polydipsia, nausea, vomiting, vasomotor disturbances, constipation.

Interaction with other drugs

Osteogenon slows down the absorption of iron preparations and tetracyclines, therefore, when they are prescribed together, the interval between the time of taking Osteogenon and these drugs should be at least 4 hours.

Features of application

Impact on the ability to drive a car and operate machinery

Osteogenon does not affect the ability to drive a car or use machinery.

Precautionary measures

Coadministration of calcium and vitamin D should be closely monitored for serum and urinary calcium levels.

A medicine that regulates metabolism in bone tissue is Osteogenon. The instructions for use explain that 830 mg tablets improve bone formation. Traumatologists explain that the drug helps in the treatment of osteoporosis and accelerates the healing of bone fractures.

Release form and composition

The dosage form of Osteogenon is an oblong, biconvex, film-coated tablet of light yellow color. The drug contains ossein-hydroxyapatite compound (OHC) as an active substance in the amount of 830 mg, which corresponds to approximately 291 mg of ossein, a protein from the group of scleroproteins, which is the main organic component of bone tissue.

Ossein includes 75 mg of non-collagen peptides/proteins, 216 mg of collagens, about 444 mg of calcium hydroxyphosphate (hydroxyapatite), including 178 mg of calcium and 82 mg of phosphorus, as well as about 95 mg of the inactive organic fraction of OGS, consisting of citric acid, glycosaminoglycan , lipids and carbonates in various proportions, depending on the specific batch of animal raw materials. Osteogenon tablets are sold in blisters of 10 pcs., 4 blisters in a cardboard pack.

Indications for use

osteopenia and imbalance of calcium and phosphorus in the body, including during pregnancy, as well as during breastfeeding;
osteoporosis of any degree of complexity, including those caused by arthritis, hyperthyroidism, kidney and liver diseases, hyperparathyroidism, as well as immobilization, the use of heparin or corticosteroids;
bone fractures, as well as for their speedy healing.

Instructions for use

According to the instructions for Osteogenon, the tablets should be swallowed whole, without crushing or chewing, with a sufficient amount of drinking water. Eating does not affect the effectiveness of the drug, so it can be taken at any time convenient for the patient. The doctor determines the specific dosage in each case individually, taking into account the indications and severity of the disease.

For osteoporosis, as a rule, 2-4 tablets are prescribed twice a day. The course of treatment can last from 6 to 12 months. For bone fractures, to speed up the rehabilitation process, you should take 2 tablets two or three times a day.

For other indications, 1-2 tablets per day are prescribed. Dose adjustment may be required in patients predisposed to urolithiasis. The duration of use of Osteogenon is determined individually.

Read also: how to take it to prevent osteoporosis.

pharmachologic effect

Osteogenon regulates the exchange of phosphorus and calcium in the body, stimulates the activity of osteoblasts and inhibits the activity of osteoclasts. As a result of this combined effect, the balance between the processes of resorption and restoration of bone tissue is restored.

Calcium is included in the drug in the form of hydroxyapatite (in a ratio of 2 to 1 with phosphorus), therefore, when using Osteogenon, calcium ions are released gradually. The drug is well absorbed from the gastrointestinal tract without the development of hypercalcemia. Calcium reduces the production of parathyroid hormone, thereby preventing hormonal bone resorption.

Phosphorus fixes calcium in bone tissue and reduces its excretion by the kidneys, thereby complementing the strengthening effect of calcium on bone tissue. The active ingredient of the drug, ossein, is an organic component. It contains osteocalcin and type I collagen, which are local regulators of bone tissue remodeling.

Ossein stimulates the processes of bone tissue formation and collagen synthesis, increases the number and activity of preosteoblasts, and reduces the formation of osteoclast precursors.

Osteogenone promotes the binding of calcium and regulates the formation of bone matrix, thereby increasing the crystallization of bone tissue. After oral administration of the drug, its active components are absorbed in the duodenum and proximal small intestine.

Contraindications

According to the instructions, Osteogenon is contraindicated for:

hypercalcemia;
childhood;
hypersensitivity to the components of the drug;
severe hypercalciuria.
Side effects
hypercalciuria;
allergic reactions;
hypercalcemia.

Children, pregnancy and breastfeeding

Osteogenon can be used during pregnancy and breastfeeding according to indications after consulting a doctor. The drug is contraindicated in children.

special instructions

This drug should not be taken together with tetracyclines and iron preparations, as these substances can form chelate complexes. If simultaneous therapy with these drugs is necessary, they should be taken at least 4 hours apart.

This medicine contains sodium chloride only in trace amounts, so Osteogenon can be used in patients with arterial hypertension.

Drug interactions

The drug may slow down the absorption of antibiotics from the group of tetracyclines and bisphosphonates, as well as drugs containing iron. Therefore, Osteogenon is good to take together with drugs containing the above-mentioned biologically active components in their chemical composition, adhering to a 4-hour interval between the use of drugs.

Analogues of the drug Osteogenon

Analogs are prescribed for the treatment of osteoporosis:

Osteochin.
OrthoOsteo.
Bivalos.
Kidron Willow.
Vitabs Calcium.
Calcium D3 Nycomed Forte.
CalciumOsteon.
Bonviva.
Xydiphone.
Osteotriol.
Calcium D3 Nycomed.
Upsavit Calcium.
Methandrostenolone.
Tobitil.
Etalfa.
Tridin.
Calcemin.
Bora Bora.
Osteocare solution.
Vitamin D3 Bon.
Phosavance.
Arthromax.
Miacalcic.
Fosamax.
Sustanon 250.
Additive calcium.
Retabolil.
Lysite (L-Lysine).
Forsteo.
Ostalon Calcium D.
Tilcotil.
Ergocalciferol.
Vectrum calcium.
Ergocalciferol (Vitamin D2).
Calcemin Advance.
Aquadetrim.
Ostalon.
Ossin.
Andriol.
Veprena.
Rezoscan.
Osteopan.

Vacation conditions and price

The average cost of Osteogenon (830 mg tablets No. 40) in Moscow is 725 rubles. Dispensed by prescription.

The instructions for use recommend storing Osteogenon out of the reach of children at a temperature not exceeding 30° C. Shelf life - 4 years.

Post Views: 209

Result: positive feedback

13 +

Advantages: Very effective, stops destruction and restores bones, quickly relieves osteoporosis

Disadvantages: Extremely expensive, uneconomical

At first, the price of Osteogenon scared me away - it’s no joke, a package for 800 rubles only lasts for 10 days! But after trying other calcium supplements, I had to return to the idea of using this remedy - they turned out to be ineffective. Osteogenon turned out to be amazingly good - in two weeks my DPID (an indicator of bone destruction) dropped from 7.2 nmol to 6.8 nmol. This inspired me very much - finally, there was a real chance to be saved from osteoporosis. I won’t hide the fact that I had to spend a lot of money on Osteognenon, but the results of the treatment cannot fail to impress. In two months, my tests have almost returned to normal - this is for me, a person with a progressive form of the disease! Judging by urine tests, calcium has stopped being washed out of the body - a sure sign that the mineral is not only well absorbed by the body, but is also “embedded” in the bone, turning it from something like a porous sponge into a normal one. After 4 months, I underwent DEXA (an examination similar to an x-ray, but more effective), and was happy to learn that the process of destruction of my beloved bones had stopped! Now, from time to time, I take the drug in courses - depending on the tests, and so far everything is fine - there has been no “news” from osteoporosis.

Result: positive feedback

Allowed for pregnant women and effective

Advantages: Safe for pregnant women, has a fast and strong effect

Disadvantages: Very expensive, uncontrolled use can lead to kidney stones

Osteogenon justifies its price by the fact that it can be used by pregnant women. By the second trimester, I was exhausted due to periodontitis and bleeding gums, and the cause of these troubles was not reduced immunity, as I thought, but a very serious mineral deficiency. I took tests - my heart sank, the doctor basically said that my teeth would soon start to crumble. He prescribed Osteogenon, saying that if I didn’t want to lose my teeth, I would have to spend money. I spent the money and I don’t regret it. I drank for a month, completely forgot about the problems with my gums - there was not even a trace of swelling left, not to mention the bleeding and pain. The drug did not cause any harm at all - I felt great, even better than before. But there is one nuance - you can’t take anything uncontrolled, especially calcium supplements. Be sure to periodically take tests for total calcium to understand when to stop taking Osteogenon - otherwise excess calcium will cause kidney stones.

Result: positive feedback

Helped both me and my son

Benefits: Replenishes minerals, helps very quickly, heals fractures, strengthens bones, nails, hair

Disadvantages: The price is steep

I used Osteogenon myself and gave it to my son. In the first case, the problem was a nightmare that began during lactation - my hair was falling out, my nails were breaking, and, dare I say it, my bones were creaking. A typical picture for mothers is that all the minerals and vitamins from the body go into milk, and you suffer from their deficiency. The drug resolved this situation very quickly and easily - a month and a half and zero problems. My hair stopped falling out altogether, my nails became noticeably thicker, and most importantly, the creaking in my joints and some kind of stiffness disappeared, because of which I used to feel like a grandmother rather than a young woman. The second case is related to the fact that at the age of 12 my son suddenly began to grow tall. The poor bones did not agree with this pace - they became thin and fragile. Five fractures in six months - this is the result. And Osteogenon helped on both sides at once - it strengthened the bones as a whole, thanks to which fractures were forgotten, and allowed existing ones to heal quickly. I’m delighted with the product, although it’s expensive, the effect is great.

Result: positive feedback

Complex and powerful remedy

Advantages: Contains substances that promote complete absorption of calcium, effective, helps quickly, does not cause harm

Disadvantages: Expensive, rarely sold anywhere

Osteogenon contains not only calcium - it also contains collagen, phosphorus, and magnesium. Thanks to this, calcium itself is completely absorbed from the drug (and not 30-40 percent, as from products like Calcium d3 Nycomed), and the effect of the drug is simply phenomenal. I broke my leg in two places, and the fractures were very serious. The healing was terribly slow - they predicted that I would have to lie in bed for six months without moving. It’s good that there is the Internet - that’s where I learned about this drug. Doctors don't prescribe it - I think because of the high price. But Osteogenon is definitely worth paying for, and I would give even more money for such an effect. You should have seen the doctor’s face when he looked at the next picture - just recently I had only “fragments” instead of bone, but here I have a completely opposite picture, healing is in full swing. The drug eventually got me back on my feet in 3 months – not bad, huh? Moreover, after this time I was able to get up and did not feel much discomfort, except for stiffness, which I managed to eliminate with the help of physiotherapy and exercises.