Food additive E383: calcium glycerophosphate for human and animal health. Food supplement E383: calcium glycerophosphate for human and animal health Calcium glycerophosphate instructions for use tablets

Glycerophosphate) is the name of the drug.

The active ingredient is calcium glycerophosphate.

The composition of the drug is a mixture of calcium (RS)-2,3-dihydroxypropyl phosphate and 2-hydroxy-1-(hydroxymethyl)-ethyl phosphate of varying composition, calcium polyhydrate.

Basic physical and chemical properties:

White flat-cylindrical tablets.

Composition of the drug:

Release form of the drug:

Pills.

Pharmacotherapeutic group:

Mineral additives.

The pharmacodynamics of the drug "Calcium glycerophosphate" are described in the instructions for its use as follows:

A remedy that is designed to replenish calcium deficiency in the body and stimulate anabolic processes in it. Its ions are directly involved in the transmission of impulses along nerve fibers, contractions of both smooth and striated muscles, myocardial function, and blood clotting. They are also necessary in the formation of bone tissue, maintaining electrolyte balance and for the normal functioning of various organs and systems. The drug normalizes calcium and phosphorus metabolism, and also exhibits a general strengthening effect.

The pharmacokinetics of the drug "Calcium glycerophosphate" are described in the instructions for its use as follows:

In the gastrointestinal tract, calcium is absorbed in ionized form and then distributed to tissues. Exactly half of its total amount contained in it is the ionic form. Five percent of it is bound in the form of ionic complexes, forty-five percent is bound to blood proteins. About twenty percent of the calcium excreted from the body leaves it in the urine, and eighty percent in the feces.

The instructions for using the drug “Calcium Glycerophosphate” are as follows:

Hypocalcemia, decreased body resistance, fatigue, malnutrition, exhaustion of the central nervous system, rickets (as a general tonic).

The drug "Calcium glycerophosphate" is prescribed to children in cases of hypocalcemia, dystrophy and rickets.

Directions for use and doses

The instructions recommend taking the drug “Calcium Glycerophosphate” as follows:

It is prescribed orally after meals. Adults take one or two tablets (two to four tenths of a gram) two to three times a day. For children, including newborns - one tablet (two tenths of a gram) one to three times a day. For children under one year of age, the tablets must be crushed and dissolved in a small amount of water, fruit juice or milk. The usual duration of treatment is from two to four weeks, repeated if necessary.

The side effects that the drug “Calcium Glycerophosphate” can have are as follows: instructions for its use:

Mild nausea, diarrhea, abdominal pain, constipation, hypercalcemia and hypercalciuria.

Contraindications to this drug:

Hypersensitivity to the drug, severe atherosclerosis, thrombosis, increased severe degree of renal failure.

Overdose of the drug:

Symptoms of overdose are hypercalcemia, severe nausea, constipation, diarrhea, abdominal pain. Treatment consists of stopping the drug and using the antidote - calcitonin, which should be administered intravenously in the amount of five to ten IU per kilogram of body weight per day.

Reviews about the drug "Calcium Glycerophosphate" are positive, including their beneficial effects as an auxiliary substance in the rapid build-up of muscle mass.

Glycerophosphate– a mineral supplement that affects tissue metabolism in the body.

Pharmacological action of the drug.

The active component of the mineral supplement is calcium glycerophosphate. It contains calcium ions accompanying:

Processes of active division and growth of cells, especially bones;
- absorption of nutrients and formation of immunity;
- blood coagulation and myocardial activity;
- transmission of nerve impulses and compression of smooth and other muscle fibers.

The action of calcium glycerophosphate is based on accelerating the processes of protein synthesis and restoring the acid-base balance in tissues, cells, and organs. Glycerophosphate helps replenish calcium deficiency and tones.

Release form.

Glycerophosphate is produced in tablet form or as a white crystalline powder. Easily soluble in water, odorless.

Indications for use.

Glycerophosphate is prescribed by a specialist in two cases:

To eliminate pathologies caused by calcium deficiency (rickets, hypocalcemia, dystrophy);
- with low body resistance (increased fatigue, nervous exhaustion, malnutrition).

Instructions for use.

Calcium glycerophosphate should be taken 2-3 times a day with water. The course of therapeutic treatment lasts 14-30 days. A single dosage for an adult is 200–500 milligrams; for children, the dose of the drug is reduced four times to 50–200 milligrams. Complex therapeutic treatment involves the simultaneous use of glycerophosphate with medications containing iron. If necessary, re-appointment and treatment with glycerophosphate is possible.

Side effects.

During therapeutic treatment with glycerophosphate, the following are quite rarely observed:

Manifestations of allergic reactions;

Intestinal disorders (constipation, diarrhea);

Pain in the stomach, nausea, and malaise.

Contraindications.

According to the instructions for use, calcium glycerophosphate is not recommended for use:

Children (under 2 years old);

Patients with hypercalcemia, manifested, for example, with metastases and sarcoidosis;

With high sensitivity and intolerance to the components of the composition;

Patients with problems with blood clotting (thrombophlebitis, thrombosis, atherosclerosis, etc.);

Together with glycosides for the heart;

In case of severe renal failure.

Overdose.

An overdose of glycerophosphate can manifest itself as pain in the stomach, nausea, diarrhea, and constipation. This painful condition indicates the formation of hypercalcemia.

If there is a high content of glycerophosphate in the blood, calcitonin is immediately administered to eliminate the manifestations of an overdose.

Special instructions.

Glycerophosphate is allowed to be drunk by pregnant women, including women during breastfeeding. It is important to know that the main component is concentrated in milk, therefore it is prohibited for a child and a nursing mother to take calcium at the same time.

Diet affects the digestibility of glycerophosphate. It is advisable to exclude rhubarb, spinach and grain bran since these products help reduce the absorption of glycerophosphate by the intestine.

Calcium glycerophosphate is a drug whose action is aimed at replenishing calcium deficiency in the human body. Available in the form of granules for the preparation of suspensions for internal use and tablets.

Pharmacological action of Calcium glycerophosphate

The main active ingredient of the drug is calcium glycerophosphate. Excipients are calcium stearate, potato starch and talc.

According to the instructions for Calcium glycerophosphate, this drug is a regulator of calcium and phosphorus metabolism and has a general strengthening and tonic effect on the body. The drug also helps to normalize metabolic processes occurring in the body.

In the gastrointestinal tract, calcium is absorbed in the form of ions, after which it is evenly distributed in the tissues. Calcium glycerophosphate is excreted mainly through the intestines during natural bowel movements.

Calcium ions take an active part in the transmission of nerve impulses, contraction of striated and smooth muscles, and help stimulate the functions of the myocardium and the blood coagulation process.

A positive effect of Glycerophosphate on children has been noted, since the drug enhances protein production, improves the functions of the nervous system, accelerates the processes of strengthening bone tissue, and also activates the metabolic process in the body.

Indications for use of Calcium glycerophosphate

The instructions for Calcium glycerophosphate indicate that the drug is recommended for the treatment of diseases such as rickets, malnutrition, hypocalcemia, exhaustion of the nervous system and a decrease in the overall resistance of the body caused by overwork.

Methods of use of Calcium glycerophosphate and dosage

Calcium glycerophosphate is intended for oral use after meals.

Adults are prescribed two tablets of the drug three times a day. Calcium glycerophosphate for children, regardless of age, is prescribed in a dosage equal to one tablet from one to three times a day. When treating children under one year of age, the tablets should be crushed and dissolved in a small amount of water. The duration of treatment should not exceed 4 weeks.

Side effects of Calcium glycerophosphate

In reviews of Calcium glycerophosphate, there are reports that the drug can cause side effects on the body in the form of diarrhea or constipation, nausea, vomiting, abdominal pain, as well as allergic reactions such as itching, burning, redness, hives, peeling of the skin .

Contraindications for use

Calcium glycerophosphate is contraindicated for treatment in people who have hypersensitivity to the components of the drug, hypercalciuria, hypercalcemia, thrombosis, atherosclerosis, renal failure, increased blood clotting.

Calcium glycerophosphate is not prescribed to children under 2 years of age.

Overdose

Numerous reviews of Calcium glycerophosphate have noted that with a significant increase in the amount of the drug taken, an increase in the side effects of the drug is observed.

Additional Information

Calcium glycerophosphate should be stored in a dark, cool, dry place out of the reach of children. The shelf life of the drug is 5 years.

All people undergoing therapy with calcium supplements, including calcium glycerophosphate, should exclude table vinegar and sorrel from their diet.

This medication can only be taken during pregnancy with the permission of a doctor, especially if the woman has already been prescribed multivitamins.

It should be borne in mind that with the simultaneous use of drugs with cardiac glycosides, Glycerophosphate enhances the toxic effects of the latter, reduces the absorption of bisphosphonates and increases the absorption of tetracyclines.

The medicine contains the active ingredient calcium glycerophosphate , also excipients: potato starch, talc, calcium stearate.

Release form

Available in the form of white tablets, flat-cylindrical in shape, with a chamfer. The package may contain 10, 20 or 50 tablets.

Also available in granule form. The Pharmacopoeia describes in detail the form and properties of the active substance (if necessary, information can be found in Latin).

pharmachologic effect

Calcium glycerophosphate - a product that contains phosphorus, which affects metabolic processes in tissues. The medicine can be a source of calcium and phosphorus.

Under its influence, protein production is activated and the functioning of the nervous system is improved.

Stimulates the process of strengthening bone tissue, activates metabolism in the human body. Calcium ions are involved in the processes of muscle contraction, blood clotting, and also in the functioning of the myocardium.

Pharmacokinetics and pharmacodynamics

Absorbed into the gastrointestinal tract in ionized form. Subsequently, about 20% of the drug is excreted from the body by the kidneys, the rest is excreted through the intestines.

Indications for use

The product is indicated for use as a tonic and strengthening medicine that stimulates the activity of the human body. It is advisable to take it for the following conditions and diseases:

poor, unbalanced diet;
exhaustion of the nervous system;
chronic fatigue;
neurasthenia , ;
malnutrition ;
dystrophy .

Contraindications

Does not apply in the following cases:

in case of high sensitivity to the drug;
with hypercalcemia, severe hypercalciuria;
at , thrombosis ;
in case of expressed ;
with severe renal failure.

Side effects

In most cases, patients tolerate this drug easily if they follow all the doctor’s recommendations when taking it. Very rarely, the following negative effects may occur:

allergic reactions;
, feeling of slight nausea;
hypercalcemia (with prolonged use).

Instructions for Calcium Glycerophosphate (Method and dosage)

The instructions for use of this medicine indicate that it should be taken orally, 1 tablet three times a day. Take the medicine before meals.

The medicine in granules is prescribed in 0.5-1 teaspoon doses, depending on the doctor’s recommendations. You need to take the product 2-3 times a day.

Children should take 1 tablet, 1-3 times a day, depending on age and specialist prescription. Pregnant women take 1 tablet twice a day. In order for the active substance to be better absorbed by the body, it is recommended to take the medicine simultaneously with vitamins D And C .

Overdose

If an overdose of Calcium glycerophosphate occurs, this may result in problems in the functions of the digestive system.

Stomach pain, nausea, constipation, and diarrhea may develop. In this case, you should immediately stop taking the drug and administer intravenously calcitonin , which is an antidote. This drug is administered at a rate of 5-10 IU/kg per day.

Interaction

When taken simultaneously with cardiac glycosides, it may enhance the toxic effect of the latter.

The drug can also increase the absorption of tetracyclines and reduce the absorption of bisphosphonates from the digestive system.

In turn, glucocorticosteroids reduce calcium absorption.

When used simultaneously with calcium glycerophosphate and drugs containing high doses of calcium, as well as thiazide diuretics, the likelihood of developing hypercalcemia increases.

Terms of sale

You can buy it in pharmacies without a prescription.

Storage conditions

Calcium glycerophosphate should be stored out of the reach of children and away from moisture.

Best before date

The shelf life of tablets and granules is 5 years.

special instructions

If the patient is taking medications that contain calcium, during this period the diet should not include dishes with table vinegar, sorrel, spinach, or rhubarb, as these products reduce the absorption of this substance.

Due to the fact that the drug is available in tablets, it is prescribed to children only from the age of two. If there are indications, the drug can be prescribed to younger children. In this case, the required dose must be crushed and dissolved in one teaspoon of water.

People who take the drug for a long time, as well as those who are simultaneously treated with cardiac glycosides and diuretics, need to monitor blood levels and calcium concentration. If these indicators increase, you need to reduce the dose of the medicine or stop taking it completely.

Absorption from the gastrointestinal tract increases with simultaneous administration vitamin D3 . This should be taken into account to prevent overdose.

Some athletes practice taking Glycerophosphate Ka in bodybuilding . Taking this medicine in bodybuilding is due to the fact that under its influence protein absorption is activated and metabolism is stimulated. pregnant is taking any multivitamin supplements.

You also need to consider that calcium passes into breast milk. Provided the newborn receives vitamin D3 or some other drugs, a woman needs to stop treatment with Calcium glycerophosphate during.

medicine

Calcium glycerophosphate

Tradename

Calcium glycerophosphate

International nonproprietary name

Dosage form

Pills

Compound

One tablet contains

active substance - calcium glycerophosphate 0.2 g;

Excipients - potato starch, calcium stearate, talc

Description

Flat-cylindrical tablets, white, beveled

Pharmacotherapeutic group

Mineral supplements. Calcium preparations

ATX code A12AA

Pharmacological properties

Pharmacokinetics

Calcium is absorbed in ionized form in the gastrointestinal tract and distributed in tissues. 50% of total calcium in blood serum is represented by ionized calcium, 5% is in the composition of anionic complexes, 45% is associated with proteins in blood plasma. About 20% of calcium is excreted in the urine, 80% through the intestines.

Pharmacodynamics

A remedy that replenishes calcium deficiency. Calcium ions take part in the transmission of nerve impulses, the contraction of smooth and striated muscles, the functioning of the myocardium, and blood clotting; necessary for the formation of bone tissue, maintaining electrolyte balance and the functioning of other systems and organs. Normalizes the exchange of calcium and phosphorus in the body, has a general strengthening effect.

Indications for use

Hypocalcemia

Reduced general resistance, fatigue and nervous exhaustion

Hypotrophy

Directions for use and doses

Prescribed orally after meals for adults: 1-2 tablets (0.2-0.4 g) 2-3 times a day, for children over 6 years old - 1 tablet (0.2 g) 1-3 times a day.

The course of treatment is 2-4 weeks, can be repeated if necessary.

Side effects

Mild nausea, diarrhea, constipation, abdominal pain

Hypercalcemia, hypercalciuria

Allergic reactions

Contraindications

Hypersensitivity to the components of the drug

Hypercalcemia

Severe hypercalciuria

Thrombosis, thrombophlebitis

Severe atherosclerosis

Increased blood clotting

Severe renal failure

Children under 6 years old

Drug interactions

When used together, calcium preparations can potentiate the therapeutic and toxic effects of cardiac glycosides, increase the absorption of tetracyclines and reduce the absorption of bisphosphonates from the gastrointestinal tract. Glucocorticosteroids reduce calcium absorption. Concomitant use with thiazide diuretics or calcium-containing drugs increases the risk of developing hypercalcemia. Loop diuretics, on the contrary, increase calcium excretion by the kidneys.

It is recommended to combine with iron supplements. When used in patients receiving cardiac glycosides and/or diuretics, as well as during long-term treatment, the concentration of calcium and creatinine in the blood should be monitored. If their concentration increases, the dose of the drug should be reduced or temporarily stopped taking it. Due to the fact that vitamin D3 increases the absorption of calcium from the gastrointestinal tract, in order to avoid calcium overdose, it is necessary to take into account the intake of vitamin D3 and calcium from other sources.

Absorption of calcium from the gastrointestinal tract may be reduced by concomitant intake of certain foods, such as spinach, rhubarb, bran and grains.

special instructions

Pregnancy, lactation period

Calcium is excreted in breast milk, which should be taken into account when prescribing the drug to women during lactation. If the child is taking vitamin D3, the woman should stop taking calcium glycerophosphate.

The use of the drug during pregnancy and lactation is possible if the benefit/risk ratio in the mother exceeds the potential risk for the fetus or infant.

Features: the effect of the drug on the ability to drive vehicles or potentially dangerous mechanisms

Does not affect

Overdose

Symptoms- increased side effects

Treatment - stop taking the drug. Calcitonin is used as an antidote, which is administered intravenously at the rate of 5.0 - 10.0 IU per 1 kg of body weight per day.

Release form and packaging

10 tablets per blister-free packaging. The outline packages, together with the appropriate number of instructions for medical use or leaflets, are placed in a corrugated cardboard box.

Storage conditions

Store at temperatures from 15 0 C to 25 0 C.

Keep out of the reach of children!

Shelf life

Do not use after the expiration date

Conditions for dispensing from pharmacies

Over the counter

Manufacturer

Lugansk, st. Kirova, 17