What is Advance? What is Advance? Knowledge for real life

The sedentary, sedentary lifestyle of modern people leads to the fact that an increasing number of people are faced with dysfunction of the musculoskeletal system, diseases of the spine and joints. The American anti-inflammatory drug Teraflex Advance can help cope with these problems - the instructions for use of this drug indicate that the analgesic effect of Ibuprofen in its composition helps reduce pain.

What is Teraflex Advance

A drug prescribed for inflammatory diseases of the musculoskeletal system, Teraflex Advance is a drug produced in the form of gelatin capsules. The active ingredients in its composition relieve the inflammatory process and participate in the restoration of damaged cartilage tissue. The doctor may recommend that the patient take Teraflex with Ibuprofen for osteoarthritis and osteochondrosis of moderate severity with moderate pain.

In addition to these diseases, this remedy can be prescribed to a patient for inflammation of the joints accompanied by pain. Indications for use according to the instructions:

• degenerative-destructive diseases of the skeletal system;
• post-traumatic conditions;
• intra-articular inflammatory processes.

The difference between Teraflex and Teraflex Advance

Drugs called Teraflex have the same indications for use, as indicated in their instructions. They have the same release form - capsule, with a similar number of capsules in the package. The differences between Teraflex and Teraflex Advance are the main active ingredients and possible negative consequences of use. Advance has added Ibuprofen, a substance from the NSAID group (non-steroidal anti-inflammatory drugs), which reduces fever and is a strong analgesic. The volume of chondroitin sulfate also differs - there is more of it in regular Teraflex than in Advance.

Since the concentration of basic substances in regular Theraflex is higher, it is recommended for use for long-term systematic treatment of chronic conditions. Advance is prescribed to relieve acute attacks. Teraflex Advance has a number of side effects that Teraflex does not have, since the concentration of active ingredients is lower and Ibuprofen is present. When using Advance, allergic reactions are possible; it is contraindicated in patients with low blood clotting rates, respiratory diseases, and stomach ulcers.

Composition

The active ingredients of Teraflex are glucosamine sulfate, chondroitin sulfate sodium and ibuprofen. In addition, according to the instructions, the composition contains:

• starch (gelatinized, corn and sodium carboxymetalized);
• stearic acid;
• silica;
• magnesium stearate;
• crospovidone;
• povidone.

Thanks to the side components, the effect of the main components is enhanced by increasing their absorption. The drug is quickly absorbed and easily excreted from the body. Chondroitin and glucosamine are chondroprotectors of artificial origin - their components can stimulate the restoration of cartilage tissue.

Release form

There are no other forms of release of Teraflex except encapsulated. One gelatin blue-white opaque capsule in a natural shell contains 600 mg of white powder with a slightly yellowish tint. The pharmacy will offer you three options for packaging the medicine - 30, 60, 120 capsules in one bottle. Focus on the expected duration of the course. Each unit of packaging is accompanied by instructions for use of the medicinal product.

How to use

According to the instructions for use, a daily dose of 6 capsules is recommended for adult patients, which should be divided into three doses. Theraflex should be taken after eating food with water. The manufacturer warns that without agreement with the attending physician, the duration of the course cannot exceed twenty-one days. Elderly people over sixty years of age should not take this medicine unless prescribed and monitored by their physician due to the strong side effects of ibuprofen.

Instructions for use

The instructions for use indicate two main diseases for which therapy using this drug is indicated: articular osteoarthritis and spinal osteochondrosis of all stages. However, thanks to the chondroprotectors included in the composition and their ability to heal cartilage tissue, it is practiced to prescribe the drug during the treatment of fractures and sprains.

The bioavailability of the main substances is: up to 30% for glucosamine and up to 15% for chondroitin. The highest concentration after absorption through the gastric mucosa occurs in intra-articular synovial fluids, cartilage tissue and liver. Its maximum level is reached within four hours after administration. The total half-life from the body can be up to three days. Ibuprofen binds to plasma proteins and, after being metabolized by the liver, is excreted from the body within twenty-four hours.

During pregnancy

The use of Teraflex during pregnancy and breastfeeding is strictly contraindicated. Ibuprofen is 95% bound to the plasma of the expectant mother. Once in the fetal body, it can cause irreversible damage to the formation of internal organs and lead to damage to the child’s nervous or cardiovascular systems. If you have indications for the use of this drug, your doctor should suggest an alternative, gentle method of therapy.

Overdose

During long courses of administration exceeding 21 days, the risk of poisoning with subsequent intoxication of the body cannot be excluded. In case of overdose, the following symptoms may occur:

• stomach ache;
• renal failure;
• tachycardia;
• dizziness;
• nausea and vomiting;
• headache.

If you suspect an overdose, stop taking the drug, read the instructions for use again and consult your doctor. After gastric lavage, you will be prescribed therapy to restore the acid-base state and correct blood pressure. Cases of overdose may occur when the recommended daily dose is regularly exceeded or during a long course of treatment. Take the medicine in strict accordance with the instructions of the instructions and your doctor.

Side effects

When using the drug, side effects may occur. This is due to the fact that the active substances in its composition are potent drugs, which increases the risk of malfunctions of the gastrointestinal tract, respiratory, cardiovascular and nervous systems. When taking Theraflex, nausea, dizziness, attention deficit disorder, and abdominal pain are possible. If one or more of the signs described above appear, interrupt therapy and get tested to reduce the likelihood of serious complications.

Contraindications

Theraflex Advance is a potent drug, so there is an impressive list of diseases and conditions for which its use is strictly contraindicated. The instructions for use contain the following contraindications:

• peptic ulcer of the stomach or duodenum;
• colitis;
• Crohn's disease;
• bleeding disorders;
• asthma;
• gastrointestinal bleeding;
• intracerebral hemorrhages;
• liver and kidney diseases;
• pregnancy and lactation period;
• age under 18 and after 65 years;
• period after coronary bypass surgery;
• individual intolerance to the components of the drug and aspirin.

• heart failure;
• renal or liver failure;
• diabetes mellitus

A connection has been identified between the body’s allergic reaction to seafood and to the components of the drug. If eating mollusks, crustaceans, shrimp, cephalopods and other sea creatures causes you discomfort, a reaction from the digestive or limbic systems of the body, there is a high probability of an allergy to this medication.

Interaction with other drugs

Teraflex Advance can be prescribed in conjunction with other medications. The patient should be aware of the possible consequences of simultaneous therapy, since in this case, interactions with other drugs cannot be avoided. The main active ingredients of Theraflex can enhance or reduce the effect of vasodilators, hypoglycemic drugs, insulin, thrombolytic, anticoagulant agents. More detailed information about the interaction is contained in the instructions for use.

Analogs

Russian analogues of Teraflex Advance are inexpensive, contain the same active ingredients in different dosages, and also have a number of additional advantages, for example, they are available in the form of an injection solution. The analgesic effect of an intramuscular injection is not as slow as when taking a capsulated drug; the activity of the main substance is higher.

To choose an analogue, focus on the composition and dosage of the active substance. Anti-inflammatory drugs for joints produced in Russia and Belarus are known and widely used:

• Chondroglucide;
• Chondrolone;
• Chondroitin-AKOS;
• Elbona;
• Mucostat;

Price Teraflex Advance

This medicine is available without a doctor's prescription, so you can order it and buy it in an online store or at any pharmacy. In Moscow pharmacies, its price starts from 600-650 rubles for thirty capsules and reaches 2500-2900 for a package of 120 pieces. On Internet resources and in pharmacy catalogs, the average price depends on packaging. You can buy Teraflex Advance from 30 capsules at a cost of 600-750 rubles per bottle, 60 - 1300-1750 rubles; 120 – 1900-2300 rubles. There are Russian and foreign analogues of the drug that have a lower cost. Depending on the manufacturer and packaging, you can purchase a drug with a similar spectrum of action at a price almost half the price of Teraflex Advance.

Video

Attention! The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and make recommendations for treatment based on the individual characteristics of a particular patient.

100 mg; additional substances: corn starch, cellulose, sodium carboxymethyl starch, stearic acid, crospovidone , silicon dioxide, magnesium stearate, povidone.

Gelatin capsules contain: gelatin, titanium dioxide, blue dye.

Release form

Gelatin capsules, with a blue cap and a white body, with white powder inside. Capsules of 30, 60 or 100 pcs. in polyethylene bottles.

pharmachologic effect

Stimulates cartilage restoration, reduces inflammation.

• Chondroitin sulfate - a substance involved in the formation of healthy cartilage tissue. At the same time, the viscosity of the synovial fluid is maintained, and enzymes that destroy cartilage are inhibited. In osteoarthritis, it reduces the manifestations of the disease and helps reduce the dose of non-steroidal anti-inflammatory drugs.
• Glucosamine sulfate improves the synthesis of substances that are the main components of cartilage, joint membranes and synovial fluid.
• Ibuprofen provides an anti-inflammatory effect, reduces pain, has an antipyretic effect due to the blockade cyclooxygenase – 1 And cyclooxygenase – 2 .

Glucosamine And chondroitin increase the analgesic effect ibuprofen .

Pharmacodynamics and pharmacokinetics

Bioavailability glucosamine - about 25%, with the highest concentration of the substance found in joint cartilage, liver and kidneys, the highest concentration is found in liver, kidneys and joint cartilage. Almost 30% of the incoming substance remains in the muscles and bones for quite a long time. The half-life is about 3 days, excreted in the urine.

Bioavailability chondroitin sulfate after absorption in the gastrointestinal tract is approximately 13%.
The maximum concentration occurs after 4 hours in the blood, and in the intra-articular fluid - within 5 hours. A large amount is found in synovial fluid. It is excreted from the body in urine.

After ingestion ibuprofen its maximum concentration occurs within 1 hour. Capable of binding to plasma proteins by 99% and penetrating into the intra-articular fluid. Metabolized in the liver, excreted by the kidneys. The half-life is about 3 hours.

Indications for use

• with moderate pain syndrome;
• large joints.

Contraindications

• ulcerative lesions of the gastrointestinal tract (, Crohn's disease , nonspecific ulcerative colitis);
• gastrointestinal bleeding;
• intracranial hemorrhages;
• bleeding disorders;
• aspirin asthma ;
• hemorrhagic diathesis ;
• children under 12 years of age;
• individual intolerance to the constituent components of the drug;
• and breastfeeding;
• increased sensitivity to and NSAIDs.

Prescribed with caution for arterial hypertension, heart failure, severe damage to kidney and liver function, gastrointestinal diseases, hyperbilirubinemia, nephrotic syndrome, blood diseases, and in elderly patients.

In case of intolerance to seafood products, the likelihood of developing an allergy to the drug increases.

Side effects

Nausea may occur diarrhea , abdominal pain, flatulence, constipation and allergic reactions. If the drug is discontinued, the side effects disappear.

Most adverse reactions occur when ibuprofen , which is part of the drug.

• Digestive system: dry mouth, stomatitis, abdominal pain, heartburn, nausea and vomiting, flatulence, constipation and diarrhea, and hepatitis.
• Respiratory system: bronchospasm and shortness of breath.
• CNS: dizziness, headache, irritability, insomnia, drowsiness, depression, hallucinations and confusion.
• Sense organs: hearing changes (noise or ringing in the ears, hearing loss), dry eyes, double vision, swelling of the eyelids and conjunctiva.
• Heart and blood vessels: rapid heartbeat, increased blood pressure, heart failure.
• urinary system: nephrotic syndrome , cystitis , nephritis , acute renal failure.
• Hematopoietic system: thrombocytopenia , anemia , leukopenia , thrombocytopenic purpura, increased duration of bleeding.
• Allergic reactions: erythematous rash , itchy skin, urticaria, , , bronchospasm, exudative erythema multiforme, Lyell's syndrome, allergic rhinitis, eosinophilia.

Instructions for use Teraflex Advance (Method and dosage)

Take 2 capsules three times a day after meals, with a small amount of water.

Overdose

Symptoms are mainly related to ibuprofen : abdominal pain, nausea, headache, vomiting, arterial hypotension, drowsiness, lethargy, tinnitus, renal failure, metabolic , increased or slow heartbeat.

For treatment, gastric lavage is used, Activated carbon , alkaline drinking, symptomatic therapy.

Interaction

Ethanol , tricyclic antidepressants , rifampicin , barbiturates When taken together, they increase the risk of liver damage.

Teraflex Advance can reduce the effect antihypertensive drugs (ACE inhibitors and calcium channel blockers), furosemide , and uricosuric agents.

The drug enhances the effects antiplatelet agents , anticoagulants And fibrinolytics , thereby increasing the risk of bleeding.

Potentiates the side effects of drugs that have ulcerogenic effect – NSAIDs, ethanol, estrogens, corticosteroids.

Drugs antacid action reduce absorption ibuprofen .

Teraflex Advance increases the effect insulin and other hypoglycemic drugs, increases the blood concentration of cardiac glycosides, methotrexate and lithium-containing drugs.

The analgesic effect of the drug may increase caffeine .

Ibuprofen reduces the anti-inflammatory and antiplatelet effect of aspirin.

, cefamandole ,

Best before date

special instructions

If long-term use of the drug is necessary, monitoring of blood counts and kidney and liver functions is mandatory.

If symptoms appear gastropathy examination is necessary to exclude the formation of ulcers and bleeding.

If it is necessary to use other analgesics and NSAIDs, you need to remember the contents of the drug ibuprofen .

Analogues of Teraflex Advance

There are no complete analogues in Russia. Only the use of chondroprotectors is possible (, Chondroglucide , Chondroflex ) in combination with NSAIDs to achieve an effect similar to Theraflex Advance.

What is the difference between Teraflex and Teraflex Advance?

Teraflex Advance additionally with ibuprofen .

"GTA: San Andreas" is one of the parts of the legendary series of games, which many fans consider the best even after the release of "GTA-5". In many ways, the reason for this is its revolutionary nature, since it was here that the players received incredible opportunities that they did not have in any project of a similar plan before. However, it is also worth noting that the game managed to maintain its popularity over such a long period of time not because of this. The reason lies in the simple abbreviation “SAMP”. It stands for “San Andreas Multiplayer”, that is, it is a multiplayer mode that allows you to team up with other gamers and play out what is happening in the city of San Andreas online. It is thanks to this mode that the popularity of the project has been maintained for such a long time.

The main and most popular mode of the multiplayer aspect of the game is RP, that is, role-playing game. Here gamers play their roles within a specific server, while following a large number of prescribed rules, which are monitored by administrators. In this article we will talk about admin teams, and not just on any server, but specifically on Advance RP, the teams of which are divided into exactly five levels to make it more convenient to delegate authority.

What it is?

So, you now have an idea of ​​what RP is in the GTA: SAMP game, but what is Advance RP? It turns out that this is one of the many projects that provide players with functional servers, competent rules and adequate control. This means that on Advance RP servers the admin teams are the clearest and most adequate. These are what will be discussed later in the article. You will learn what powers the administration receives and what responsible persons at one level or another can do. The Advance RP commands, as mentioned above, are divided into five levels, and then you can consider each of them separately.

First level

At the first level of administration, Advance RP commands are quite basic and simple. They don't give much freedom of action, but they do provide some means of control. For example, you can use the /sp command to bring up a monitoring panel for players on the server. In addition, you can view information about each player and their equipment using the /weap command, and the /stats combination will allow you to view the statistics of a particular participant located in the north. Naturally, the Advance RP commands are not limited to the first level, so you will also have to familiarize yourself with the capabilities that higher-level administrators receive.

Second level

Naturally, the commands of Advance RP admins of the second level differ from those that can be used by admins of the first level. Of course, higher level administrators can use all the same commands that lower level administrators use, but they now have a number of combinations that are more advanced. For example, the /get command allows you to find out absolutely all the information about a specific player’s account, and with /kick you can kick any player from the server if his behavior does not comply with the rules. Just remember that a kick is not a ban, so the player can return at any time. You can also, for example, silence any player by prohibiting him from writing in the chat and thereby cutting off his path to roleplaying. This is done using the /mute command, but you should also be aware of the existence of the /unmute command, which returns the player the right to write in the chat. As you can see, the commands in SAMP in Advance RP are very diverse, so you will have something to work with.

Third level

As for the third level, here the teams of SAMP administrators in Advance RP become much more diverse. If at the first level you had the opportunity to use only six administrator commands, then at the second the number of commands increased to 12. And at the third level you already have 25 commands available to you. And the most important of them, naturally, is /ban, which allows you to ban players, that is, not just throw them out of the server, but at the same time prohibit them from returning. In addition, you have a whole host of possibilities, such as teleporting to a home or business (/house or /biz), taking control of a business (/inter), viewing the IP address of any player (/ip) and so on. Particular attention should be paid to the /jail and /unjail commands, which allow you to jail any player, as well as release him from prison.

Fourth level

As you may have already noticed, the number of commands available to the administrator increases significantly as his level increases. And at the fourth level you will be able to use 40 commands, so almost all the functionality will be available to you. What does this level give you? First, you will be able to use the /rban command, which allows you to ban players by IP address. Also, only fourth-level admins can both ban and unblock players. As far as you remember, third-level admins can only send players to a ban, but cannot return them from there.

Also, the admin of this level has a large number of powerful game commands that allow you to create a car out of nowhere, set specific weather outside, set the player’s health to a certain level, and much more. It would seem, what else could be better? What other commands can a level 5 admin use? It's time to find out.

Fifth level

The fifth level of administration in the game is distinguished by the fact that the commands for restarting the server /gmx, deleting a player account /delacc, and issuing leadership /makeleader are available for use on it. Naturally, only level 5 admins can use the /arang command to promote or demote other admins.

It is no wonder why most people studying and practicing English confuse the adjectives and - the difference is just one letter. Today we are going to draw a parallel between these words to explain the difference. To begin with, we note that “ " is a form derived from the verb (advance, go forward) and performs the function of an adjective in a sentence. The word “advance” itself can be a noun, a verb, or an adjective. Today we'll look at the word "advance" as an adjective.

Both words are used with different meanings. Let's start with an adjective meaning " advanced, preliminary " Pay attention to the following phrases and meanings in examples of the use of this adjective:

• I prefer booking via Internet – I prefer advance purchase via the Internet.
• We practice ticket sales a month before the performance. – we practice pre-sales of tickets a month before the performance.
• Advance publicity is a common thing in marketing - advanced advertising is often used in marketing.
• In case of your refusal you should submit an notice - in case of your refusal, you must provide prior notice.
• We give you the warning and will take relevant measures in case you fail to fulfill your obligations. – we warn you in advance and will take appropriate action if you fail to fulfill your obligations.
• You can use the right of call of our specialist who will check the equipment - you can use the right to pre-call our specialist who will check the equipment.

Google shortcode

Well, now we can move on to the adjective, which is mainly used in the following meanings: “ advanced, promising, modernized, progressive, improved, modern, in-depth, advanced, well prepared»:

• The advanced research in medicine will save thousands of lives - advanced research in medicine will save thousands of people.
• The rival company has stolen all our advanced developments - a competing company stole all our promising developments.
• Your advanced concepts will save our project - your advanced ideas will save our project.
• I advise you to buy the new advanced model of the gas stove - I advise you to buy a new advanced model of the gas stove.
• Every student of the Oxford University gets the advanced education - every student at Oxford University receives an advanced education.
• I have applied for the advanced course in English - I applied for an advanced English course.
• If you have any advanced opinions/ ideas please share them with us - if you have advanced ideas, share with us.
• The government supports development of the advanced industries - the government supports modern industries.
• The USA will build there the advanced naval base - The USA will build an advanced naval base there.
• The advanced cosmetology of the 21st century will help people to stay young as much as possible - advanced cosmetology of the 21st century will help people stay young as long as possible.
• We use only technology of building - we use only advanced construction technologies.
• Tom was the most advanced learner in his class - Tom was the most advanced student in the class.

However, advanced can be not only “advanced”, for example the phrase “ advanced in years"means be elderly/old, « advanced night» — late night, A " advanced disease» — advanced disease.

• People who are advanced in years often think of their past and analyze the whole life - older people often think about their past and analyze their whole life.
• Unfortunately doctors could do nothing to help Helen because the advanced stage of a cancer - unfortunately, doctors could do nothing to help Helen because the cancer was advanced.
• I can’t come to your place now when the night is far advanced, but early tomorrow I’ll call on you - I can’t come to you now, late at night, but early in the morning I’ll come.

Therefore, under no circumstances should one say “ advanced ticket sales", because sales cannot be advanced, only preliminary – , and also you can’t say “ advance system", because systems cannot be preliminary, only improved - .

Among diseases of the musculoskeletal system, the lion's share consists of processes accompanied by pathological changes in cartilage tissue. As a rule, these are long-term and steadily progressing diseases in which articular cartilage and intervertebral discs become thinner, lose their firmness and elasticity, and become more fragile.

These diseases include coxarthrosis (damage to the hip joint), gonarthrosis (damage to the knee joint), osteochondrosis (damage to the spine and intervertebral discs) and many others. The destruction of cartilage leads to unpleasant symptoms, such as pain in the joints and back, difficulty moving, and a deterioration in the quality of life. Often the disease ends in disability.

How to treat these diseases?

Treatment of diseases of the musculoskeletal system is a rather complex task. It lasts more than one month, and sometimes can last throughout life. The patient needs not only to take medications, but also regularly undergo courses of physiotherapy, massage, do therapeutic exercises, monitor his diet and control other aspects of his life.

The following drugs are widely used in the treatment of joint diseases:

• Nonsteroidal anti-inflammatory drugs (NSAIDs), which have analgesic, anti-inflammatory and antipyretic effects.
• Corticosteroids.
• Cytostatics.
• Immunomodulators.
• Vitamins, dietary supplements and many others.

Among the variety of medicines, chondroprotectors stand out - drugs that are designed to stop the destruction of cartilage tissue. It is believed that long-term use of these drugs promotes cartilage restoration and faster healing.

Chondroprotectors – what are they?

Chondroprotectors are a group of dietary supplements and medications that are designed to protect cartilage from damaging factors of the external and internal environment. They contain various components of natural and artificial origin, which, according to laboratory and clinical studies, stop the destruction of cartilage tissue, stimulate its restoration and improve the quality of life of patients:

• Hyaluronic acid.
• Glycosaminoglycan-peptide complex.
• Glucosamine and glucosamine sulfate.
• Chondroitin sulfate.
• Other drugs.

Most medications come in tablet form for daily use. Despite the ease of use, the benefits of the tablets are low, since only a small amount of the drug is absorbed in the gastrointestinal tract, and an even smaller percentage penetrates the synovium of the joint, which is known to be poorly permeable to most substances.

It is more effective to administer drugs intramuscularly. In this case, the drug is not exposed to the aggressive action of gastric juice, there is no loss of it, which occurs when consumed in tablet form, and the drug does not pass through the portal system and is not transformed in the liver.

The most effective way to administer chondroprotectors is to inject them directly into the joint cavity. For this purpose, artificial synovial fluid and hyaluronic acid are used. With intra-articular administration of drugs, there are no common undesirable effects that are observed with tablets and intramuscular injections. However, intra-articular administration of chondroprotectors may be accompanied by pain and other unpleasant sensations.

Teraflex Advance

Teraflex Advance is a combination drug that contains glucosamine, chondroitin sulfate and ibuprofen. It has a complex mechanism of action:

• Glucosamine stimulates the formation of components of the joint membranes, synovial fluid and cartilage tissue, such as proteoglycans, hyaluronic and chondroitinsulfuric acids and others.
• Chondroitin sulfate, being an integral component of cartilage tissue, is directly involved in its restoration, protects against damage and improves joint mobility.
• Ibuprofen is a pain reliever from the group of nonsteroidal anti-inflammatory drugs (NSAIDs).

The presence of such components in the composition of the drug Teraflex Advance, each of which has its own evidence base, indicates that it is a full-fledged drug and not a dietary supplement.

Teraflex Advance is widely used as a means of maintenance therapy for arthrosis of large joints (coxarthrosis, gonarthrosis), as well as osteochondrosis and dorsopathy. The drug is available in capsules with a fixed dosage.

Unlike dietary supplements, Theraflex Advance has a number of contraindications:

• Individual intolerance.
• Peptic ulcer of the stomach and duodenum.
• Crohn's disease, ulcerative colitis.
• Bronchial asthma, especially in combination with nasal polyposis.
• Blood clotting disorders.
• External and internal bleeding.
• Pregnancy, breastfeeding period.
• Age up to 18 years.

Teraflex Advance should be taken in long courses, but self-administration without medical supervision can last no more than 3 weeks, since ibuprofen in this drug can lead to the development of dangerous side effects.

Teraflex analogs

Not all patients can afford to purchase Teraflex Advance at the prices of regular pharmacies, so finding a close analogue of the drug becomes task number one.

The patient can purchase medications from other pharmaceutical companies that contain the same substances as Theraflex. A full-fledged analogue is the American drug ARTRA, but it is at least 2-3 times more expensive than Teraflex. Another option is the Indian CONDROnova, which is also available in ointment form.

Instead of the complex Teraflex Advance, you can use the drugs included in its composition separately:

• Glucosamine is produced under the trade names DONA, Chondroxide Maximum, Elbona and others.
• Chondroitin sulfate is produced under the names Chondrogard, Structum, Chondrolone, Artradol, Mucosat and others.
• Ibuprofen is a well-known Nurofen.

It should be noted that the total cost of these three drugs is often much higher than when purchasing one package of Teraflex Advance.

The cheapest analogue of Teraflex Advance is nothing more than jellied meat. This dish, as you know, is prepared from meat on the bones, and they contain a large number of different substances, including glucosamine and chondroitin. Some doctors strongly recommend that their patients not spend money on medications, but rather boil several kilograms of jellied meat and consume it every day.

Where's the evidence?

Despite the general positive attitude of patients and the medical community towards Theraflex and similar drugs, there is good reason to believe that such admiration is formed more by advertising than by the actual effect of the drug. To this day, there is no convincing evidence of the effectiveness of Theraflex in the treatment of coxarthrosis, gonarthrosis and osteochondrosis. The belief in the therapeutic effect of the drug is based rather on the fact that glucosamine and chondroitin are components of cartilage, therefore, they will help restore damaged cartilage tissue.

However, such assumptions are incompatible with the principles of evidence-based medicine, which operates with facts and statistics, rather than theory and speculation. Because of this, more and more doctors refuse to prescribe Teraflex to their patients, because it is not only quite expensive, but also completely useless for some diseases. For example, clinical trials have shown that Theraflex is completely ineffective in treating Perthes disease, in which the head of the femur actually “dies.”