Duphaston is a hormonal drug for women's health. Side effects from the use of duphaston and patient reviews

In the absence of pregnancy or problems with miscarriage, women are often prescribed hormone replacement therapy.

Duphaston, a drug that replenishes, is responsible for the onset of pregnancy and the creation of optimal conditions for the further development of the fertilized egg.

The “pregnancy hormone”, progesterone, is responsible for preparing the endometrium of the uterus to receive a fertilized egg. Almost the entire first trimester, enzyme production occurs due to the enzyme, which ensures the vital activity of the zygote.

Starting from the second trimester, the production of progesterone becomes one of the main tasks of the placenta. It turns out that the enzyme is necessary for the body throughout the entire period of bearing a child.

The hormone also plays an important role during conception, since the onset of ovulation depends on it. Thanks to progesterone, the muscles of the uterus relax, and it does not interfere with embryo implantation.

Therefore, it is so important to eliminate enzyme deficiency before conception and monitor its concentration during pregnancy if the woman has previously been diagnosed with miscarriage.

To compensate for the deficiency of the hormone, drugs were created that completely replicate the composition of the enzyme. Among them is Duphaston, a synthetic analogue of progesterone.

The drug is available in the form of coated tablets. Each form contains 10 mg of dydrogesterone, the active substance. In the list of auxiliary ingredients you can read about the presence of lactose monohydrate, colloidal silicon dioxide, magnesium stearate, corn starch. The shell consists of hypromellose, titanium dioxide, polyethylene glycol.

The drug goes on sale in cardboard packs containing a blister with 20 tablets.

Currently, there are several progesterone analogues. Why is Duphaston preferred in some cases?

When comparing the characteristics of this drug and, for example, the disadvantages and advantages of both drugs become clear:

Plant raw materials are used to produce Utrozhestan. The drug is a natural analogue of the enzyme, in contrast to the completely synthetic Duphaston. The structure and composition of Utrozhestan are identical to the hormone produced by the woman’s body.
The naturalness of Utrozhestan sometimes becomes a disadvantage, since the drug has a negative effect on the functionality of the liver and is contraindicated in diseases of the organ.
Unlike Utrozhestan, the synthetic analogue is considered practically harmless and can be safely taken during pregnancy.
Utrozhestan is available in the form of capsules, which can be taken intravaginally or orally. Duphaston is produced only in tablet form, which can make it difficult to take the drug in case of severe toxicosis.
Taking Duphaston does not cause side effects, such as drowsiness, irritability, or a constant feeling of weakness. But Utrozhestan has virtually no effect on weight.
While Utrozhestan can be used in exceptional cases while breastfeeding, Duphaston is prohibited, since the drug easily penetrates the mammary glands and is present in milk.

The doctor decides which progesterone analogue will be effective based on the woman’s medical history and depending on the course of pregnancy.

Planning pregnancy with Duphaston

Duphaston tablets are often prescribed. The drug is quickly absorbed into the blood from the digestive tract.

The maximum concentration of the enzyme in plasma is observed 2 hours after administration.

A special regimen has been developed according to which it is recommended to drink Duphaston, just at the stage of pregnancy planning, in order to ensure sufficient levels of progesterone.

During this time, take 1 tablet of Duphaston daily. If necessary, the dosage of Duphaston can be increased.

In order for the pregnancy to proceed normally, it is necessary to continue treatment for six months and only after that plan to conceive. This also applies to preparation for in vitro fertilization.

Before the course of treatment, a woman must undergo an examination to determine the level of progesterone in the middle of the 2nd phase of the cycle.

In order for the blood sample test to be accurate, you need to know when she ovulates. To do this, it is recommended to monitor your basal temperature.

If you have irregular periods, it is advisable to take blood samples twice to determine progesterone. The analysis will allow you to clarify the dosage of the drug and make the necessary changes to the dosage regimen.

Pregnancy with Duphaston occurs after 3-6 months of treatment.

The drug is taken every cycle, starting immediately from the 1st day following ovulation.

If pregnancy does not occur, after the next ovulation it is necessary to continue the course of treatment until conception occurs.

Stop taking it only after the arrival of menstruation, making sure there is no pregnancy. If a delay occurs, the drug should be continued, as abrupt withdrawal provokes.

If pregnancy has not occurred within a year after the first course, treatment tactics should be changed, a thorough diagnosis should be carried out, and a different progesterone analogue should be used. Cancellation of Duphaston in this case does not pose any danger.

During conception and normal progesterone production, the dosage reduction of Duphaston should occur smoothly. How exactly the drug should be discontinued is decided by the doctor based on the tests of the pregnant woman.

Most often, taking the hormonal drug continues until 18-20 weeks, when the placenta has developed sufficiently and can independently supply the body with the enzyme.

Prescription of Duphaston for threatened miscarriage

In the early stages of pregnancy, progesterone deficiency may begin. In this case, it is recommended to take Duphaston to maintain pregnancy and maintain the level of the required enzyme.

How to take Duphaston during pregnancy?

The drug is prescribed according to individual indications. Typically, the dose is 10 mg per day. But in special cases, the dosage can be increased to 30 or even 40 mg.

To prevent the death of the fetus, it is necessary to inform the doctor about nagging painful sensations at their first appearance.

with endometriosis - growth of the endometrium of the uterus beyond its limits;
for infertility associated with progesterone deficiency;
with frequent miscarriages due to progesterone deficiency;
if there is a threat of miscarriage;
with irregular periods;
in the presence of premenstrual syndrome;
with uterine dysfunctional bleeding;
with primary and secondary aminorrhea.

As hormone replacement therapy, Duphaston is prescribed for hormonal imbalance caused by decreased ovarian functionality, as well as in the absence of the corpus luteum.

The drug can be used prophylactically if a woman has a history of.

Duphaston is also used in the treatment of ovarian cysts. Progesterone is produced in small quantities by the adrenal glands, so if their functionality decreases, Duphaston can be used to adjust hormonal levels.

Personal experience
I took Duphaston twice - it was prescribed to me during my first and last pregnancy. The first time I was prescribed it was at almost 13 weeks. There were no special instructions, but due to past unsuccessful experiences, the doctors simply played it safe.

I read somewhere that the drug can cause miscarriage in the late stages. This is wrong. I took the course until the 20th week inclusive. A friend was also prescribed Duphaston until the 27th week, because... the fetus was positioned incorrectly and blocked the bottom of the pharynx. In each case, the appointment is individual. I took 2 tablets for the first month, then 1 tablet. The drug is expensive, so they allowed me to reduce the dose, and there was no need to take it so often.

In the second case, I voluntarily refused Duphaston. By this time there are already three children. I didn’t want to stuff the fetus with various hormones, especially since there were enough vitamins. They prescribed it to me as an additional complex. I just didn’t want to take hormonal pills. From 6 to 13 weeks, as the drug was prescribed, I took regular folic acid instead.

As far as I remember, Duphaston can be prescribed to those who are at risk of miscarriage. It’s a pity that I didn’t take it when I really needed it. Therefore, girls, be careful and attentive to your health and what is prescribed to you.

Tatiana, 29.

Contraindications for use

Duphaston is safe for the developing fetus, but the drug has side effects that lead to discomfort for the woman:

on the ingredients included in the drug;
increased destruction of red blood cells;
migraine;
a slight decrease in liver functionality, manifested by jaundice of the skin and mild pain in the area of the right hypochondrium;
breakthrough bleeding that disappears with increasing dosage of the drug;
high sensitivity of the mammary glands;
hives;
peripheral edema.

Is Duphaston harmful?

Contraindications to taking Duphaston are lactation and hypersensitivity. The drug is prescribed with caution if there is skin itching or allergies during previous pregnancies, since sometimes Duphaston can provoke Quincke's edema.

Treatment with Duphaston allows a woman to conceive a long-awaited child and eliminate the threat of spontaneous abortion at an early stage. However, if there are significant side effects, you should consult a gynecologist who will prescribe a different progesterone analogue.

The trade name of the drug is Duphaston. Belongs to the pharmacological group “hormonal and antihormonal drugs, analogues”. The main active ingredient is dydrosterone. This is an artificial analogue of the natural female hormone progesterone.

Didrosterone does not have an estrogenic effect, does not enhance the effect of testosterone, and does not have corticoid properties. The peculiarity of this dosage form is that it does not change the processes of thermogenesis. Therefore, the composition of the drug allows you to monitor ovulation by basal temperature.

How does the hormonal drug work?

The product is presented only in tablet form. What do the instructions for use of the drug say?

"Duphaston" does not affect metabolism;
dydrosterone has a selective effect on progestin receptors in the uterine cavity;
regulates normal secretory processes in the body;
does not disrupt the course of ovulatory processes;
does not suppress menstrual function;
do not cause premature puberty in the unborn baby;
does not affect blood clotting parameters even with long-term use;
improves the condition of the endometrium, preventing the development of hyperplasia and oncopathology of the inner layer of the uterus;
does not have a masculinizing (androgenic) effect on the woman and the fetus.

After the drug enters the stomach, it is completely absorbed within 2 hours. Metabolites are excreted through the genitourinary system after 72 hours. After this, dydosterone is not detected in the urine. The main active ingredient does not accumulate either in the kidneys or in the liver.

Important! The drug "Duphaston" is not an oral contraceptive and is not intended to stimulate ovulation.

What does the medicine contain?

The main active ingredient is dydrosterone in the amount of 10 mg per tablet. The product contains lactose monohydrate, hypromellose, corn starch, colloidal silicon dioxide and magnesium stearate. These are excipients.

The color is white, the shape of the tablets is biconvex. The tablets have a dividing strip and are taken orally. The package contains 20 tablets.

Pharmakinetics - what happens in the body?

Disposal of dydosterone occurs in the liver. Residues are eliminated through the urinary system. After 24 hours, about 85% of the active substance will be released, and after 48 hours, no traces of the drug can be detected in the blood.

Indications for prescribing hormonal drugs

Duphaston tablets are prescribed for the following pathologies:

Lack of progesterone, which is confirmed by appropriate tests:
- endometriosis;
- infertility caused by luteal insufficiency;
- habitual or threatened miscarriage due to lack of progesterone;
- painful PMS;
- irregularities in the monthly cycle, prolonged absence of menstruation;
- uterine bleeding of various origins.
Hormone replacement therapy.

The drug is prescribed to neutralize the negative effects of estrogens on the inner layer of the uterus - the endometrium.

Instructions for taking the drug

Duphaston tablets are taken orally. The dosage of the drug must correspond to the diagnosis. Treatment is carried out only as prescribed by a doctor and under medical supervision.

Endometriosis - dosage 10 mg (1 tablet) 2 to 3 times a day. Start either from the 5th to the 25th day of the monthly cycle, or continuous use.
Infertility, which is caused by luteal insufficiency, is prescribed 1 tablet per day from the 14th to the 25th day of the cycle. The drug is taken for at least six months or 6 cycles. If conception has already occurred, then Duphaston should be taken further, as if there is a threat of abortion.
Threatened abortion - take 40 mg (4 tablets) once. Then 1 tablet every 8 hours until the situation returns to normal. If symptoms begin to increase again, the dose of the drug should be increased again. Next, Duphaston should be taken until 12–20 weeks of pregnancy.
Habitual abortion - take 1 tablet 2 times a day. Treatment should be continued until the 20th week of pregnancy, then the dosage is gradually reduced.
PMS - prescribed 1 tablet 2 times a day. Treatment is carried out from the 11th to the 25th day of the cycle. The drug is prescribed for a period of 3 to 6 months.
Painful menstruation - 1 tablet 2 times a day. Use is indicated from the 5th to the 25th day of the cycle.
Irregular monthly cycle - the drug is prescribed 1 tablet. 2 times a day. Duphaston should be used from the 11th to the 25th day of the cycle.
Long-term absence of menstruation (amenorrhea) - complex treatment - estrogen-containing drugs, 1 tablet per day, starting from the 1st day of the cycle. From the 11th day of the cycle, treatment is supplemented with Duphaston. These drugs should be taken until the 25th day of the cycle. Application is intended for at least 3 menstrual cycles.
Dysfunctional uterine bleeding - the dose is 1 tablet. 2 times a day. The duration of treatment is from 5 to 7 days. To prevent bleeding, the drug is prescribed - 1 table. 2 times a day. Therapy is carried out from the 11th to the 25th day of the cycle.
Hormone replacement therapy is prescribed in combination with estrogens, 1 tablet once a day for 2 weeks within a 28-day cycle. Usually the reception takes place in the last 14 days of the cycle. If the response to progesterone therapy is not detected by ultrasound and is not confirmed by tests, then the dose should be revised upward.
Use during pregnancy - as prescribed by your doctor. If the drug is prescribed during lactation, then feeding the baby should be stopped.

Contraindications

The instructions for Duphaston state that the drug cannot be used for:

hypersensitivity to dydrogesterone and other drugs that contain progesterone. Allergy to auxiliary components;
irritation and itching of the skin during previous pregnancies;
prescribed with caution for diseases associated with metabolic disorders, epilepsy, kidney disease, migraines;
"Duphaston" is not prescribed to women with galactose intolerance or malabsorption syndrome;
During replacement therapy, ultrasound monitoring of the pelvic organs and mammographic examinations are required.

A separate line is an overdose of Duphaston. Cases of overdose when taking the drug correctly have not been observed. If the tablets are taken accidentally, the treatment is symptomatic.

Side effects of the drug

The instructions state that all side effects of Duphaston are classified as very rare:

Anemia – lack of iron in the blood;

Allergic reactions to the main or auxiliary substances;

Headaches, migraines;

Extremely rare - liver damage, which may be accompanied by symptoms of jaundice, pain in the epigastric region;

Extremely rare – breakthrough uterine bleeding. These conditions can be neutralized by increasing the dosage of the drug. Pain and swelling in the chest;

Itching, skin rash, swelling of the lower extremities. In severe cases, Quincke's edema.

How does the drug behave with other drugs?

Be sure to tell your gynecologist if you are taking the following medications:

Rifampicin;

Phenobarbital.

The use of these drugs reduces the effectiveness of dydrogesterone.

Attention! Replacement therapy

In patients who require replacement therapy, it is necessary to exclude all conditions and contraindications associated with taking estrogen-containing drugs.

Before starting treatment, a complete medical history is required. Particular attention should be paid if the medical history indicates progesterone-dependent tumors - for example, meningiomas.

Patients on replacement therapy should undergo regular examinations and have mammograms. The doctor should warn the patient what chest symptoms to pay attention to.

Rules for the sale and storage of Duphaston

The drug is stored indoors at normal temperatures. No refrigerator or other equipment required. Shelf life if stored correctly is 5 years. Duphaston is not a prescription drug. The medicine cannot be used after the expiration date has expired.

Duphaston is an artificial analogue of the female sex hormone progesterone. It is prescribed to women who have reduced production of natural progesterone, which leads to such phenomena as their complete absence, recurrent miscarriage, severe premenstrual pain and others.

Duphaston carries few side effects and, since it does not affect ovulation, pregnancy can occur while taking this drug. However, we cannot say that Duphaston is completely safe and does not pose any side effects.

Among the most common side effects from taking Duphaston are bloating, headaches and dizziness, and nausea. The drug also has hormonal effects - as a result of hormonal changes in disorders in the body, breast sensitivity may increase, acne may appear, libido may change (both upward and backward), minor bleeding may appear between periods, and weight may increase.

In some, albeit rare cases, Duphaston leads to anemia and liver dysfunction. In addition, you need to be careful if you are prone to allergies. Some women are allergic to dydrogestron, one of the components of the drug. Appears as a rash.

A contraindication to taking duphaston is the patient’s history of cardiovascular diseases, liver and gallbladder diseases, ovarian and breast cancer.

Among the side effects from taking Duphaston:

genitals – breakthrough uterine bleeding, increased sensitivity of the mammary glands;
central nervous system – migraines;
gastrointestinal tract - general weakness and malaise, impaired liver function, jaundice, abdominal pain;
skin – rash and itching;
hematopoietic system – homolytic anemia (rare);
allergic reactions in the form of urticaria and angioedema;
extremely rare, but still occurs - peripheral edema.

Contraindications to the use of Duphaston

Firstly, this is an individual intolerance to the constituent components of the drug, the appearance of a rash and skin itching during a previous pregnancy, and the period of breastfeeding. Secondly, Duphaston is not prescribed for certain types of enzyme deficiency, as well as for malabsorption syndrome.

Before prescribing Duphaston, you must undergo an examination. Based on its results, the doctor must determine the dosage and duration of the course of taking the drug.

Reviews about the drug

If we talk about the opinions of women who took this drug for one reason or another, they differ somewhat. Some patients speak only positively about Duphaston, saying that it was thanks to him that they managed to get rid of pregnancy, maintain a pregnancy and carry a child to term.

Others complain of multiple side effects, constant dizziness and nausea, unexplained discharge between periods and changes in the monthly cycle.

Of course, it is impossible to predict who will be affected by the side effects of the drug and who will not be affected by them, but it is extremely important to take it strictly according to the regimen drawn up by the doctor and not deviate from it. You also cannot act according to your own intentions - together with your girlfriend.

Despite the recognition of the safety of the drug, if taken incorrectly, Duphaston faces serious consequences in the form of disruption of the menstrual cycle, which is very difficult and time-consuming to restore. And it is especially dangerous to experiment with taking Duphaston during pregnancy - this can lead not only to side effects, but also to irreversible consequences.

The drug Duphaston is prescribed if a woman is diagnosed with luteal phase deficiency, in order to reduce the negative symptoms of the onset of menstruation, as well as for the treatment of other hormonal disorders. Side effects of Duphaston can have a serious effect on a woman’s body, so before taking the drug you should definitely consult a doctor.

Taking pills when planning pregnancy is prescribed if a woman has previously had miscarriages. After the desired conception occurs, the doctor prescribes therapy on a systematic basis in the 1st and 2nd trimesters of pregnancy. At the same time, regular examinations are carried out, on the basis of which the doses taken are adjusted.

Sometimes the result of termination of pregnancy and miscarriage is the development of infection in the uterine area. In such cases, the doctor prescribes general strengthening medications, as well as vitamin complexes, the main effect of which is aimed at increasing the protective functions of the body.

Another indication for the use of the drug is endometriosis. Thanks to drug therapy, it is possible to stop the process of proliferation of the membranes lining the uterus. This phenomenon often occurs at the very beginning of the menstrual cycle, infertility due to hormonal disorders, and also during PMS.

So, the drug is prescribed in the following most common situations:

threat of pregnancy failure. It is detected after an ultrasound and laboratory tests of blood and urine. Depending on the improvement or, conversely, deterioration in the well-being and condition of the pregnant woman, the doctor changes the dosage of the drug;
insufficient secretion of progesterone, which causes the impossibility of pregnancy. With the help of Duphaston, a woman’s hormonal levels are corrected and normalized;
PMS. The drug also reduces back pain;
absence of menstrual bleeding over the last 2-3 menstrual cycles;
uterine bleeding.

The active components of the drug help stop abnormal bleeding, so the drug is prescribed by specialists for various pathologies and diseases of the genital organs.

How does taking the drug affect the body?

Duphaston has really helped many women cope with. During the course of treatment with tablets, the patient may experience the following changes in well-being:

headaches, attacks of dizziness;
feelings of nausea and bloating;
allergic skin rashes and acne;
increased sensitivity and soreness of the mammary glands;
development of swelling as a result of fluid retention in the body;
weight gain;
kidney failure;
anemia.

The side effect of Duphaston on body weight is one of the most “unloved” for women. To minimize these effects, you should work with your doctor to determine the optimal dosage.

If a woman's body does not produce enough of the hormone progesterone, she will suffer from severe pain during menstruation and may have had miscarriages in the past. Taking pills helps solve hormonal problems and prevent miscarriages.

Like any drug, the drug has its contraindications, as well as side effects, some of which have a fairly serious effect on the female body. Depending on the system and organs, the following reactions are noted:

From the side of the central nervous system. Periodic headaches and migraines appear.
Reproductive system. Uterine bleeding. To eliminate this symptom, the attending physician may prescribe an increase in the previously prescribed dosage. In addition to bleeding, there is increased sensitivity of the mammary glands. Giving preference to underwear and clothing made from natural materials can reduce a woman’s discomfort during this period.
Gastrointestinal tract. The liver suffers the most during treatment. Due to disruption of her work, the patient develops malaise and her skin becomes jaundiced. Unpleasant and even painful sensations can also appear in the stomach.
Epidermis. The appearance of skin rashes that are atypical for a woman, similar to an allergic reaction. The presence of itching and discomfort in the area of the spots that have appeared, as well as slight swelling.

There are known cases of individual intolerance to the drug. For example, if during the first pregnancy the expectant mother experienced itching or any other unpleasant side symptoms from taking the pills, then during the second pregnancy the doctor selects analogues and drugs with similar effects.

To calculate the optimal dosage of medication, the patient is prescribed a full examination. This measure allows you to determine the total duration of taking Duphaston, as well as on which days of the menstrual cycle it is most preferable to take the drug.

Contraindications to the use of Duphaston

An allergic reaction to a drug is a fairly common contraindication for taking any medication. If the patient notices the initial manifestations of a rash, malaise or other side effects, the medication should be stopped immediately.

Before starting a course of treatment with the drug, it is recommended to conduct tests to identify adverse and allergic reactions. In some cases, doctors prescribe combination therapy using estrogen. Here you should also be extremely careful, since the hormone has its own list of contraindications.

Other contraindications are:

cardiovascular pathologies;
liver diseases;
cancer pathologies;
disorders of the body's immune system.

During breastfeeding, taking the drug is prohibited, since the components included in the tablets are absorbed into the blood and pose a real threat to the newborn. In other cases, Duphaston is well tolerated, and side effects are extremely rare.

Women who have vehicles at their disposal should remember that the pills do not affect concentration and attention. Therefore, there is no need to transfer to public transport.

If a woman’s production of this hormone is impaired, that is, the body does not produce enough of it, then doctors prescribe Duphaston.

Due to insufficiency of progesterone, the monthly cycle is disrupted, and it can happen that menstruation completely disappears, it is impossible to carry a child to term, premenstrual syndrome is strongly expressed in the form of pain in the lower abdomen.

Duphaston has quite a few side effects, and since this drug does not have any effect on ovulation, pregnancy may occur while taking Duphaston.

But, of course, it is impossible to talk about the complete safety of this drug, and it still has side effects.

Causes

The most common side effects when taking Duphaston:

headache;
dizziness;
nausea;
bloating.

There are also hormonal consequences, as a result of which acne appears, breast sensitivity increases, the level of sexual desire changes (becomes stronger or weaker), bleeding may appear that is not associated with the monthly cycle, and body weight increases.

It happens that taking Duphaston leads to impaired liver function and anemia.

And besides, an allergy to Duphaston is also possible; the allergen is mainly one of the components - dydrogestron. The most common symptom of this allergy is a skin rash.

There are contraindications for taking Duphaston, such as:

cardiovascular diseases;
ovarian and breast cancer;
gallbladder disease;
liver diseases;
some types of enzyme deficiency;
malabsorption syndrome;
individual intolerance to the drug.

The most common side effects from Duphaston manifest themselves as follows:

reproductive system - breast sensitivity increases, breakthrough uterine bleeding occurs;
CNS - headaches, migraines;
Gastrointestinal tract - abdominal pain, impaired liver function, malaise and general weakness;
skin - itching, redness, rash;
in the field of hematopoiesis - homolytic anemia occurs occasionally;
peripheral edema - very rare;
allergic reaction.

Symptoms of an allergy to duphaston

An allergic reaction is one of the negative side effects of taking Duphaston. Most often, an allergy to Duphaston manifests itself in the form of skin rashes such as urticaria, which are characterized by severe itching. Then there are other manifestations of allergies to this drug:

skin rash;
hives;
nausea, vomiting;
bloating;
stomach ache;
frequent sneezing;
allergic rhinitis (nasal congestion, difficulty breathing, excessive nasal discharge);
increased lacrimation;
itching in the eyes;
headache;
dizziness.

Such symptoms often appear immediately or a short time after taking the drug. Other allergy symptoms may take longer to appear:

very severe migraines;
the appearance of edema - peripheral (on the hands, legs, lips, etc.) or angioedema;
choking (difficulty inhaling and breathing through the nose and mouth);
deterioration of sense of smell;
the sense of taste of food disappears;
Quincke's edema;
increase in body temperature.

If such symptoms appear, it is advisable to seek medical help as soon as possible, especially if the allergic reaction is severe.

Treatment of allergies to duphaston

Duphaston is prescribed only by a doctor, and if there is any doubt whether this drug is suitable for you or not, and whether it will cause an allergic reaction, you must first undergo a medical examination. In addition, this must be done in order to exclude the presence of other contraindications, except for individual intolerance.

If allergies manifest themselves in the form of swelling, then after stopping the drug they disappear in about a month.
You also need to exclude or minimize contact with other allergens: house dust, animal hair, feather pillow fillings, plant pollen, etc.
Fenistil helps with swelling due to allergies. This drug has no contraindications for pregnancy. Fenistil can be taken in the form of oral drops, gel or tablets. This drug in drops should be taken three times a day, 20-40 drops at a time. This dose is intended for an adult.
Fenistil gel should be applied to the affected areas of the skin in a thin layer 2-4 times during the day. During pregnancy, it should be used with caution, especially in the first trimester. The drug in tablets can be taken 2-3 times a day, 1-2.5 mg at a time, but the daily dose cannot be exceeded (it is 5 mg).
In cases where it is impossible to refuse Duphaston, it can be taken together with suitable antihistamines, for example, Kestin. Kestin tablets are taken one piece once a day, that is, the daily dose for an adult is 20 mg.
If the body reacts sharply to taking Duphaston even with antihistamines, then you should completely abandon it and replace it with safer analogues, for example, the drug "Utrozhestan", which is similar in its pharmacological action to Duphaston.