Polyoxidonium is a comprehensive defense of the body against infection. Polyoxidonium - description, instructions for use of polyoxidonium, video, indications, contraindications Polyoxidonium studies of side effects

Active substance

ATX:

Pharmacological group

Nosological classification (ICD-10)

Compound

Description of the dosage form

Pills: round, flat-cylindrical, white or white with a yellowish tint, with a chamfer, with a notch on one side and with the inscription “PO” on the other.

porous mass of white color with a yellowish tint.

Suppositories: torpedo-shaped, light yellow in color with a faint specific odor of cocoa butter. Suppositories must be homogeneous. An air rod or funnel-shaped depression is allowed on the cut.

pharmachologic effect

pharmachologic effect- antioxidant, detoxifying, immunomodulatory.

Pharmacodynamics

Azoximer bromide has a complex immunomodulatory, detoxifying, antioxidant, and moderate anti-inflammatory effect.

The basis of the mechanism of immunomodulatory action of azoximer bromide is a direct effect on phagocytic cells and natural killer cells, as well as stimulation of antibody formation, the synthesis of interferon-alpha and interferon-gamma.

The detoxification and antioxidant properties of azoximer bromide are largely determined by the structure and high-molecular nature of the drug.

Azoximer bromide increases the body's resistance to local and generalized infections of bacterial, fungal and viral etiology. Restores immunity in secondary immunodeficiency conditions caused by various infections, injuries, complications after surgery, burns, autoimmune diseases, malignant neoplasms, the use of chemotherapeutic agents, cytostatics, steroid hormones.

A characteristic feature of azoximer bromide when applied locally (intranasally, sublingually) is the ability to activate factors of the body's early defense against infection: the drug stimulates the bactericidal properties of neutrophils, macrophages, enhances their ability to absorb bacteria, increases the bactericidal properties of saliva and secretions of the mucous membranes of the upper respiratory tract.

Azoximer bromide blocks soluble toxic substances and microparticles, has the ability to remove toxins and heavy metal salts from the body, and inhibits lipid peroxidation, both by intercepting free radicals and by eliminating catalytically active Fe 2+ ions.

Azoximer bromide reduces the inflammatory response by normalizing the synthesis of pro- and anti-inflammatory cytokines.

Azoximer bromide is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects. Azoximer bromide is odorless and tasteless, and does not have a local irritant effect when applied to the mucous membranes of the nose and oropharynx.

Pharmacokinetics

Pills: after oral administration, it is quickly absorbed from the gastrointestinal tract, bioavailability is approximately 70%. Cmax in blood plasma is reached 3 hours after oral administration. Pharmacokinetics is linear (plasma concentration is proportional to the dose taken). Azoximer bromide is a hydrophilic compound. The apparent V d is approximately 0.5 l/kg, which indicates that the drug is distributed mainly in the intercellular fluid. Half-absorption period 35 minutes, T 1/2 - 18 hours.

Lyophilisate for the preparation of solution for injection and topical use: Azoximer bromide is characterized by rapid absorption and a high rate of distribution in the body.

Cmax of the drug in the blood with intramuscular administration is achieved after 40 minutes.

T1/2 for different ages from 36 to 65 hours. The bioavailability of the drug is high - more than 90% when administered parenterally.

For tablets and lyophilisate for the preparation of solution for injection and topical use: Azoximer bromide is quickly distributed throughout all organs and tissues of the body, penetrates the BBB and the blood-ophthalmic barrier. There is no cumulative effect. In the body, azoximer bromide undergoes biodegradation to low molecular weight oligomers and is excreted mainly by the kidneys, with feces - no more than 3%.

Suppositories: when administered rectally, it has high bioavailability (at least 70%), reaching Cmax in the blood 1 hour after administration. The half-life of distribution is about 0.5 hours, the half-life of elimination is 36.2 hours.

In the body it is hydrolyzed to oligomers, which are excreted primarily by the kidneys. There is no cumulative effect.

Indications of the drug Polyoxidonium®

Pills

For adults and children over 3 years of age - treatment and prevention of acute and chronic respiratory diseases in the stage of exacerbation and remission.

Treatment as part of complex therapy:

acute and chronic recurrent infectious and inflammatory diseases of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear;

allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections.

As monotherapy:

prevention of recurrent herpetic infection of the nasal and labial area;

prevention of exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear;

correction of secondary immunodeficiencies resulting from aging or exposure to adverse factors.

In adults and children from 6 months - treatment and prevention of infectious and inflammatory diseases (viral, bacterial and fungal etiology) in the acute and remission stages.

Treatment of adults (in complex therapy):

chronic recurrent infectious and inflammatory diseases of various localizations (viral, bacterial and fungal etiology) in the acute stage;

acute viral and bacterial infections of the ENT organs, upper and lower respiratory tract, gynecological and urological diseases;

acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by bacterial, viral and fungal infections;

in oncology during and after chemotherapy and radiation therapy - a decrease in the immunosuppressive, nephro- and hepatotoxic effects of drugs;

generalized forms of surgical infections - to activate regenerative processes (fractures, burns, trophic ulcers);

rheumatoid arthritis, complicated by bacterial, viral and fungal infections, due to long-term use of immunosuppressants;

pulmonary tuberculosis.

Treatment of children over 6 months (in complex therapy):

acute and exacerbation of chronic inflammatory diseases of any localization (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, acute respiratory viral infection), caused by pathogens of bacterial, viral, fungal infections;

acute allergic and toxic-allergic conditions complicated by bacterial, viral and fungal infections;

bronchial asthma complicated by chronic respiratory tract infections;

atopic dermatitis complicated by purulent infection;

intestinal dysbiosis (in combination with specific therapy).

Prevention (monotherapy) in children over 6 months and adults:

influenza and acute respiratory diseases;

postoperative infectious complications.

Suppositories

In adults and children over 6 years of age - treatment and prevention of infectious and inflammatory diseases (viral, bacterial and fungal etiology), in the acute and remission stages.

For treatment (in complex therapy):

acute and exacerbation of chronic recurrent infectious and inflammatory diseases of various localization, bacterial, viral and fungal etiology;

inflammatory diseases of the urogenital tract (urethritis, cystitis, pyelonephritis, prostatitis, salpingoophoritis, endomyometritis, colpitis, cervicitis, cervicosis, bacterial vaginosis);

various forms of pulmonary tuberculosis;

allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by recurrent bacterial, fungal and viral infections;

rheumatoid arthritis, complicated by recurrent bacterial, fungal and viral infections, due to long-term use of immunosuppressants;

to activate regenerative processes (fractures, burns, trophic ulcers);

in oncology during and after chemotherapy and radiation therapy - a decrease in the immunosuppressive, nephro- and hepatotoxic effects of drugs.

For prevention (monotherapy):

recurrent herpetic infection of the urogenital tract;

exacerbation of chronic foci of infections;

influenza and other acute respiratory infections in the pre-epidemic and epidemic periods in immunocompromised individuals;

secondary immunodeficiencies resulting from aging or exposure to adverse factors.

Contraindications

increased individual sensitivity;

acute renal failure;

pregnancy (no clinical experience of use);

lactation period.

For tablets additionally

children under 3 years of age;

lactose intolerance, lactase deficiency, glucose-galactose malabsorption.

For lyophilisate for the preparation of solution for injection and topical use (optional)

Children's age up to 6 months.

For suppositories additionally

Children's age up to 6 years.

Carefully

Common to all dosage forms— chronic renal failure (used no more than 2 times a week).

Use during pregnancy and breastfeeding

The use of the drug Polyoxidonium ® is contraindicated for pregnant women and women during breastfeeding (there is no clinical experience of use). An experimental study of the drug Polyoxidonium ® in animals revealed no effect on the generative function (fertility) of males and females, embryotoxic and teratogenic effects, or effects on fetal development, either when the drug was administered throughout pregnancy or during lactation.

Side effects

Pills: no side effects were reported.

Lyophilisate for the preparation of solution for injection and topical use: When using the drug Polyoxidonium ®, the following general and local reactions occurred:

Uncommon (≥1/1000 to<1/100) — болезненность, покраснение и уплотнение кожи в месте введения.

Very rarely (≥1/10,000) - increased body temperature to 37.3 °C, mild anxiety, chills during the first hour after injection, allergic reactions.

Suppositories: very rarely - local reactions in the form of redness, swelling, itching of the perianal area, vaginal itching (due to individual sensitivity to the components of the drug).

Interaction

Tablets, lyophilisate for the preparation of solution for injection and topical use, suppositories: drug interaction has not been established. It is possible to use Polyoxidonium ® with many drugs, incl. compatible with antibiotics, antiviral, antifungal and antihistamines, bronchodilators, corticosteroids, cytostatics and β-adrenergic agonists.

Azoximer bromide does not inhibit isoenzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 cytochrome P450, therefore the drug is compatible with antibiotics, antiviral, antifungal and antihistamines, corticosteroids and cytostatics.

If the patient is taking the above or other medications (including over-the-counter medications), you should consult your doctor before starting to take Polyoxidonium ®.

Directions for use and doses

The drug should be used only according to the indications, the method of administration and in the doses indicated in the instructions. If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.

Pills

Orally And sublingually, 20-30 minutes before meals, daily 2 times a day.

Children over 10 years old and adults - 1 tablet each, children from 3 to 10 years old - 1/2 tablet each. (6 mg).

If necessary, repeated courses of therapy are possible after 3-4 months.

When the drug is re-prescribed, its effectiveness does not decrease.

Sublingually

For treatment in adults:

Inflammatory processes of the oropharynx - 1 table. 2 times a day for 10 days;

Exacerbations of chronic diseases of the upper respiratory tract, paranasal sinuses, chronic otitis media - 1 table. 2 times a day for 10 days;

Allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - 1 table. 2 times a day for 10 days.

For treatment in children from 3 to 10 years:

Influenza and acute respiratory infections - 1/2 table each. 2 times a day for 7 days;

Inflammatory processes of the oropharynx - 1/2 table. 2 times a day for 7 days;

Allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - 1/2 table. 2 times a day for 7 days.

For treatment in children over 10 years of age:

Influenza and acute respiratory infections - 1 table each. 2 times a day for 7 days;

Inflammatory processes of the oropharynx - 1 table. 2 times a day for 7 days;

Exacerbations of chronic diseases of the upper respiratory tract, paranasal sinuses, chronic otitis media - 1 table. 2 times a day for 7 days;

Allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - 1 table. 2 times a day for 7 days.

For prevention in adults:

Influenza and acute respiratory infections in the pre-epidemic period - 1 table each. per day for 10 days;

Recurrent herpetic infection of the nasal and labial area - 1 table each. 2 times a day for 10 days;

Exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear - 1 table. once a day for 10 days;

Secondary immunodeficiencies arising due to aging or exposure to adverse factors - 1 table. 1 time per day for 10 days.

For prevention in children aged 3 to 10 years:

Influenza and acute respiratory infections in the pre-epidemic period - 1/2 table. per day for 7 days;

Recurrent herpetic infection of the nasal and labial area - 1/2 table. 2 times a day for 7 days;

Exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear - 1/2 table. once a day for 10 days.

For prevention in children over 10 years of age:

Influenza and acute respiratory infections in the pre-epidemic period - 1 table each. per day for 7 days;

Recurrent herpetic infection of the nasal and labial area - 1 table each. 2 times a day for 7 days;

Exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear, 1 table. once a day for 10 days.

Orally

For treatment in adults and children over 10 years of age:

Diseases of the upper and lower respiratory tract - 1 table each. 2 times 10 days.

Lyophilisate for the preparation of solution for injection and topical use

Adults

Routes of administration of the drug Polyoxidonium ®: parenteral, intranasal, sublingual.

Methods of application, dosage regimen, need and frequency of subsequent courses of therapy are selected by the doctor depending on the severity of the disease and the age of the patient.

Preparation of solutions for parenteral administration (i.m. and i.v.):

For intramuscular administration, the drug Polyoxidonium ® - 3 mg is dissolved in 1 ml (6 mg dose - in 2 ml) water for injection or 0.9% sodium chloride solution. After adding the solvent, the drug is left for 2-3 minutes to swell, then mixed with rotational movements without shaking;

For intravenous drip administration, the drug Polyoxidonium ® is dissolved in 2 ml of sterile 0.9% sodium chloride solution. After adding the solvent, the drug is left for 2-3 minutes to swell, then mixed with rotational movements. The dose calculated for the patient is sterilely transferred into a bottle/bag with 0.9% sodium chloride solution.

The prepared solution for parenteral administration cannot be stored.

Preparation of a solution for intranasal and sublingual use:

For children, a dose of 3 mg is dissolved in 1 ml (20 drops), a dose of 6 mg is dissolved in 2 ml (40 drops) (one drop (0.05 ml) of the prepared solution contains 0.15 mg of the drug);

For adults, a dose of 6 mg is dissolved in 1 ml (20 drops) of distilled water, 0.9% sodium chloride solution or boiled water at room temperature.

The prepared solution for intranasal and sublingual use can be stored at room temperature in the manufacturer's packaging for up to 48 hours.

IM or IV (drip)

The drug is prescribed to adults in doses of 6-12 mg 1 time per day, daily, every other day or 1-2 times a week, depending on the diagnosis and severity of the disease.

Parenterally

- for acute viral and bacterial infections of the ENT organs, upper and lower respiratory tract, gynecological and urological diseases: 6 mg daily for 3 days, then every other day with a total course of 10 injections;

- for chronic recurrent infectious and inflammatory diseases of various localization, bacterial, viral and fungal etiology, in the acute stage: 6 mg every other day for 5 injections, then 2 times a week for a course of at least 10 injections;

- for acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by bacterial, viral and fungal infections: 6-12 mg, course of 5 injections;

- for rheumatoid arthritis, complicated by bacterial, viral and fungal infections, against the background of long-term use of immunosuppressants: 6 mg every other day for 5 injections, then 2 times a week for a course of 10 injections;

- for generalized forms of surgical infections: 6 mg daily for 3 days, then every other day, in a course of 10 injections;

- to activate regenerative processes (fractures, burns, trophic ulcers): 6 mg for 3 days, then every other day, a course of 10 injections;

- for the prevention of postoperative infectious complications: 6 mg every other day 5 injections;

- for pulmonary tuberculosis: 6 mg 2 times a week for a course of 20 injections.

In cancer patients:

Before and during chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents - 6 mg every other day for a course of 10 injections; further, the frequency of administration is determined by the doctor depending on the tolerability and duration of chemotherapy and radiation therapy;

To prevent the immunosuppressive effect of the tumor, to correct immunodeficiency after chemotherapy and radiation therapy, after surgical removal of the tumor, long-term use of the drug Polyoxidonium ® (from 2-3 months to 1 year) 6 mg 1-2 times a week is indicated. When prescribing a long course, there is no effect of accumulation, toxicity or addiction.

Intranasally

Prescribe 6 mg/day (3 drops in each nasal passage 3 times a day, for 10 days):

For the treatment of acute and exacerbations of chronic infections of the ENT organs;

To enhance the regenerative processes of the mucous membranes;

To prevent complications and relapses of chronic diseases;

For the prevention of influenza and ARVI.

Routes of administration and doses in children

Parenteral, intranasal, sublingual. Methods of application are selected by the doctor depending on the diagnosis, severity of the disease, age and body weight of the patient.

Parenteral (IM or IV)

Prescribed to children from 6 months at a dose of 0.1-0.15 mg/kg daily, every other day or 2 times a week with a course of 5-10 injections.

Intranasal and sublingual

Daily at a daily dose of 0.15 mg/kg for up to 10 days. The drug is administered 1-3 drops into each nasal passage or under the tongue with an interval of at least 1-2 hours, in 2-3 doses per day.

To prepare a solution for intranasal and sublingual use, a dose of 3 mg is dissolved in 1 ml (20 drops), a dose of 6 mg is dissolved in 2 ml (40 drops) of distilled water, 0.9% sodium chloride solution or boiled water at room temperature. One drop (0.05 ml) of the prepared solution contains 0.15 mg of the drug.

Calculation of the daily dose for intranasal and sublingual use is presented in Table 1.

For a child weighing more than 20 kg, the daily dose is calculated based on 1 drop per 1 kg, but not more than 40 drops (6 mg of active substance). The prepared solution for intranasal and sublingual use can be stored at room temperature in the manufacturer's packaging for up to 48 hours.

Parenterally

For acute and exacerbations of chronic inflammatory diseases of any localization (including ENT organs (sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, ARVI), caused by pathogens of bacterial, viral, fungal infections: 0.1 mg/kg 3 days in a row, then every other day with a course of 10 injections.

For acute allergic and toxic-allergic conditions (including bronchial asthma, atopic dermatitis), complicated by bacterial, viral and fungal infections: IV drip at a dose of 0.1 mg/kg, 3 days daily, then every other day , a course of 10 injections in combination with basic therapy.

Intranasally

Every day, 1-2 drops in each nasal passage 3 times a day for up to 10 days (see calculation of the daily dose of the drug for intranasal and sublingual administration in Table 1):

For acute and chronic rhinitis, rhinosinusitis, adenoiditis (treatment and prevention of exacerbations);

For preoperative preparation of patients during surgical interventions for ENT pathology, as well as in the postoperative period in order to prevent infectious complications or relapses of the disease;

Treatment and prevention of influenza and other acute respiratory viral infections (within 1 month before the expected epidemic), at any time after the onset of the disease and during the period of convalescence).

Sublingually

For children of early, preschool and primary school age: daily at a daily dose of 0.15 mg/kg in 2 divided doses for 10 days:

For adenoiditis, hypertrophy of the tonsils: (as a component of conservative treatment);

For preoperative preparation and postoperative rehabilitation;

For seasonal prevention of exacerbations of chronic foci of infections of the oropharynx, upper respiratory tract, inner and middle ear;

For the treatment of intestinal dysbiosis (in combination with basic therapy) for 10 days.

Suppositories

Once a day, every day, every other day or 2 times a week.

If necessary, repeated courses of therapy are possible after 3-4 months. When the drug is re-prescribed, its effectiveness does not decrease.

For treatment in adults:

Rectally 1 sup. 1 time per day after bowel cleansing;

Vaginally for gynecological diseases, 1 supp. Once a day (at night) it is inserted into the vagina in a lying position.

Directions for use and doses for adults

For chronic infectious and inflammatory diseases in the acute stage - suppositories 12 mg once a day every day for 3 days, then every other day. Course of treatment - 10 supp.;

For acute infectious processes and to activate regenerative processes (fractures, burns, trophic ulcers) - suppositories 12 mg 1 time per day, daily. Course of treatment - 10 supp.;

For gynecological diseases - suppositories 12 mg 1 time per day every day for 3 days, then every other day. Course of treatment 10 supp.;

For exacerbation of urological diseases (urethritis, pyelonephritis, cystitis, prostatitis) - suppositories 12 mg 1 time per day daily. Course of treatment - 10 supp.;

For pulmonary tuberculosis - suppositories 12 mg once a day every day for 3 days, then every other day. Course of treatment 20 sup. Further, it is possible to use maintenance therapy - suppositories 6 mg 2 times a week, for a course of up to 2-3 months;

In complex therapy of oncological diseases during chemotherapy and radiation therapy - suppositories 12 mg daily 2-3 days before the start of the course of chemotherapy or radiation therapy. Next - 12 mg 2 times a week, for a course of up to 20 sup.;

For allergic diseases complicated by infectious syndrome, suppositories 12 mg 1 time per day daily. Course of treatment - 10 supp.;

For rheumatoid arthritis - suppositories 12 mg every other day. Course of treatment - 10 supp.

Exacerbations of chronic foci of infections - 10 supp.;

Influenza and ARVI - suppositories 12 mg once a day. Course - 10 supp.;

For secondary immunodeficiencies resulting from aging - suppositories 12 mg 2 times a week. Course - 10 sup., 2-3 times a year.

For the treatment of children and adolescents from 6 to 18 years of age:

For children and adolescents from 6 to 18 years old, suppositories are administered only rectally, 1 suppository. 6 mg 1 time per day after bowel cleansing:

For chronic infectious and inflammatory diseases in the acute stage - suppositories 6 mg 1 time per day daily for 3 days, then every other day. Course of treatment - 10 supp.;

For acute infectious processes and to activate regenerative processes (fractures, burns, trophic ulcers) - suppositories 6 mg 1 time per day, daily. Course of treatment - 10 supp.;

For exacerbation of urological diseases (urethritis, pyelonephritis, cystitis, prostatitis) - suppositories 6 mg 1 time per day daily. Course of treatment - 10 supp.;

For pulmonary tuberculosis - suppositories 6 mg once a day every day for 3 days, then every other day. The course of treatment is 20 supp. Further, it is possible to use maintenance therapy - suppositories 6 mg 2 times a week, for a course of up to 2-3 months;

In complex therapy of oncological diseases during chemotherapy and radiation therapy - suppositories 6 mg daily 2-3 days before the start of the course of chemotherapy or radiation therapy. Next - 6 mg 2 times a week, for a course of up to 20 sup.;

For allergic diseases complicated by an infectious syndrome - suppositories 6 mg 1 time per day daily. Course of treatment - 10 supp.;

For rheumatoid arthritis - 6 mg suppositories every other day. Course of treatment - 10 supp.

For prevention (monotherapy):

Exacerbations of chronic foci of infections, recurrent herpetic infections of the urogenital tract - suppositories 6 mg every other day. Course - 10 supp.;

Influenza and ARVI - suppositories 6 mg once a day. Course - 10 supp.

For patients receiving long-term immunosuppressive therapy, cancer patients, those exposed to radiation, and those with an acquired defect of the immune system (HIV), long-term maintenance therapy with Polyoxidonium ® is indicated for 2-3 months to 1 year (adults - 12 mg, children over 6 years - 6 mg 1-2 times a week).

Overdose

Cases of overdose of the drug Polyoxidonium ® are unknown.

special instructions

If an allergic reaction develops, you should stop using the drug Polyoxidonium ® and consult a doctor.

If it is necessary to stop taking the drug Polyoxidonium ®, cancellation can be done immediately, without gradually reducing the dose.

If you miss the next dose of the drug, its subsequent use should be carried out as usual, as indicated in these instructions or recommended by your doctor. The patient should not administer a double dose to compensate for missed doses.

Do not use the drug if there are visual signs of its unsuitability (packaging defect, change in color of the tablet).

Impact on the ability to drive vehicles and other mechanisms. The use of the drug Polyoxidonium ® does not affect the ability to perform potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions (including driving vehicles, working with moving mechanisms).

Release form

Immunomodulator

Active substance

Azoximer bromide

Release form, composition and packaging

◊ Vaginal and rectal suppositories torpedo-shaped, light yellow in color, with a faint specific odor of cocoa butter; suppositories must be homogeneous; an air rod or a funnel-shaped depression is allowed on the cut.

- in case of complicated acute respiratory infections or acute respiratory viral infections;

— to activate regenerative processes (including fractures, burns, trophic ulcers);

— for the rehabilitation of frequently and long-term (4-5 times a year) ill persons;

— during and after chemotherapy and radiation therapy of tumors;

- to reduce the nephro- and hepatotoxic effects of drugs.

As monotherapy:

- for the prevention of recurrent herpetic infections;

— for seasonal prevention of exacerbations of chronic foci of infections;

— for the prevention of influenza and acute respiratory infections in the pre-epidemic period;

— for the correction of secondary immunodeficiencies that arise due to aging or exposure to adverse factors.

Contraindications

- increased individual sensitivity;

- acute renal failure;

- pregnancy;

- period of breastfeeding;

- children under 6 years of age.

Carefully: chronic renal failure (prescribed no more than 2 times a week).

Dosage

The drug is intended for rectal and intravaginal administration, 1 suppository 1 time/day. The method and dosage regimen is determined by the doctor depending on the diagnosis, severity and severity of the process. The drug can be used daily, every other day or 2 times a week.

Suppositories 12 mg are used in adults rectally and intravaginally.

Suppositories 6 mg are used in children over 6 years old rectal only; at adults- rectally and intravaginally.

Rectally, suppositories are inserted into the rectum after cleansing the intestines. Intravaginally, suppositories are inserted into the vagina in a lying position, 1 time/day at night.

Standard application scheme

1 suppository 6 mg or 12 mg 1 time/day daily for 3 days, then every other day a course of 10-20 suppositories.

If necessary, the course of treatment is repeated after 3-4 months. The need and frequency of subsequent courses of therapy are determined by the doctor; if the drug is re-prescribed, the effectiveness does not decrease.

Patients with chronic immune deficiency(including those receiving immunosuppressive therapy for a long time, those with cancer, HIV, those exposed to radiation), long-term maintenance therapy with the drug is indicated for 2-3 months to 1 year ( adults 12 mg each, children over 6 years old- 6 mg 1-2 times a week).

At chronic infectious and inflammatory diseases in the acute stage- according to the standard regimen, in the remission stage - 1 suppository of 12 mg every 1-2 days, a total course of 10-15 suppositories.

At acute infectious processes And to activate regenerative processes (fractures, burns, trophic ulcers)- 1 suppository daily. The course of treatment is 10-15 suppositories.

At pulmonary tuberculosis the drug is prescribed according to the standard regimen. The course of treatment is at least 15 suppositories, then it is possible to use maintenance therapy of 20 suppositories per week for up to 2-3 months.

On the background chemotherapy and radiation therapy of tumors begin to administer 1 suppository daily 2-3 days before the start of the course of therapy. Further, the frequency of administration of suppositories is determined by the doctor depending on the nature and duration of chemotherapy and radiation therapy.

For rehabilitation of frequent (more than 4-5 times a year) and long-term ill persons and at rheumatoid arthritis- 1 suppository every other day. The course of treatment is 10-15 suppositories.

At rheumatoid arthritis- suppositories 12 mg (in adults) and 6 mg (y children), in one day. The course of treatment is 10 suppositories.

As monotherapy

For seasonal prevention of exacerbations of chronic infectious diseases and for the prevention of recurrent herpetic infections the drug is used every other day adults 6-12 mg, in children- 6 mg each. Course - 10 suppositories.

For correction of secondary immunodeficiencies, prevention of influenza and acute respiratory infections the drug is prescribed according to the standard regimen.

At gynecological diseases the drug is prescribed rectally and intravaginally according to the standard regimen.

Side effects

Very rarely: local reactions in the form of redness, swelling, itching of the perianal area, vaginal itching due to individual sensitivity to the components of the drug.

Overdose

Currently, no cases of overdose of the drug Polyoxidonium have been reported.

Drug interactions

Azoximer bromide does not inhibit the cytochrome P450 isoenzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, therefore the drug is compatible with many drugs, incl. with antibiotics, antifungal and antihistamines, corticosteroids and cytostatics.

special instructions

If it is necessary to discontinue drug therapy, discontinuation can be carried out immediately.

If you miss a single dose of the drug, you should take it as soon as possible, but if it is time to take the next dose, the dose should not be increased.

The drug should not be used if there are visual signs of its unsuitability (defective packaging, discoloration of suppositories).

If an allergic reaction develops, the patient should stop using the drug and consult a doctor.

Use in pediatrics

For children and adolescents aged 6 to 18 years, suppositories are administered only rectally.

Impact on the ability to drive vehicles and machinery

The use of the drug Polyoxidonium does not affect the ability to drive vehicles, maintain machinery and other types of work that require increased concentration and speed of psychomotor reactions.

Pregnancy and lactation

Contraindicated for use during pregnancy and breastfeeding. There is no clinical experience of use.

IN experimental studies The drug Polyoxidonium in animals has not revealed embryotoxic or teratogenic effects or effects on fetal development.

Use in childhood

The use of the drug in children under 6 years of age is contraindicated (there is no clinical experience with its use).

Storage conditions and periods

The drug should be stored in a dry place, out of reach of children, at a temperature of 2° to 15°C. Shelf life - 2 years.

Polyoxidonium Polyoxidonium

Active substance

›› Azoximer bromide*

Latin name

Pharmacological group: Immunomodulators

Nosological classification (ICD-10)

Composition and release form

in a blister pack 10 pcs.; in a cardboard pack 1 or 2 packages.

in ampoules or vials of colorless or dark neutral glass, 4.5 mg; in a cardboard pack there are 5 ampoules or bottles; or in a blister pack of 5 ampoules or bottles; in a cardboard pack 1 package; or in a cardboard pack of 5 ampoules or bottles complete with a solvent in ampoules (5 ampoules of water for injection or 5 ampoules of 0.9% isotonic sodium chloride solution).

in ampoules or vials of colorless or dark neutral glass, 9 mg; in a cardboard pack there are 5 ampoules or bottles; or in a blister pack of 5 ampoules or bottles; in a cardboard pack 1 package; or in a cardboard pack of 5 ampoules or bottles complete with a solvent in ampoules (5 ampoules of water for injection or 5 ampoules of 0.9% isotonic sodium chloride solution).



in a blister pack 5 pcs.; in a cardboard pack 2 packs.

Description of the dosage form

Pills: from white with a yellowish tint to yellow with an orange tint, flat-cylindrical, with a chamfer, with a notch on one side and the inscription “PO” on the other. Subtle inclusions of more intense color are allowed.
Lyophilisate for the preparation of solution for injection and topical use: porous mass from white with a yellowish tint to yellow. The drug is hygroscopic and photosensitive.
Suppositories: torpedo-shaped, light yellow in color with a faint specific odor of cocoa butter.

pharmachologic effect

pharmachologic effect- immunomodulatory, detoxifying, antioxidant.

Pharmacokinetics

Polyoxidonium has high bioavailability (89%); time to reach Cmax in the blood after intramuscular administration - 40 minutes; quickly distributed throughout all organs and tissues. The half-life of distribution in the body with intravenous administration is 25 minutes, T1/2 (slow phase) is 25.4 hours, with intramuscular administration is 36.2 hours. In the body, the drug is hydrolyzed to oligomers, which are excreted primarily by the kidneys.
For suppositories: bioavailability - high (up to 70%); Cmax in the blood is reached 1 hour after administration; T 1/2 (fast phase - about 30 minutes, slow phase - 36.2 hours).

Pharmacodynamics

Increases the body's resistance to bacterial, fungal and viral infections. The basis of the mechanism of immunomodulatory action of Polyoxidonium is a direct effect on phagocytic cells and natural killer cells, as well as stimulation of antibody formation.
Restores immune responses in secondary immunodeficiency conditions caused by infections, injuries, burns, malignant neoplasms, complications after surgery, the use of chemotherapeutic agents, incl. cytostatics, steroid hormones.
When administered sublingually, Polyoxidonium activates lymphoid cells located in the bronchi, nasal cavity, and Eustachian tubes, thereby increasing the resistance of these organs to infectious agents.
When administered orally, Polyoxidonium activates lymphoid cells located in the intestine, namely B-cells that produce secretory IgA.
The consequence of this is an increase in the resistance of the gastrointestinal tract and respiratory tract to infectious agents. In addition, when administered orally, Polyoxidonium activates tissue macrophages, which facilitates faster elimination of the pathogen from the body in the presence of a focus of infection.
Along with the immunomodulatory effect, Polyoxidonium has pronounced detoxifying and antioxidant activity, which is determined by the structure and high-molecular nature of the drug. Increases the resistance of cell membranes to the cytotoxic effects of drugs and chemicals, reduces their toxicity.
The use of Polyoxidonium in complex therapy can increase the efficiency and shorten the duration of treatment, significantly reduce the use of antibiotics, bronchodilators, corticosteroids, and extend the period of remission.
The drug is well tolerated, does not have mitogenic activity, or antigenic properties; does not have allergenic, mutagenic, embryotoxic, teratogenic or carcinogenic effects.

Indications

Pills.
In adults and adolescents over 12 years of age in complex therapy:
acute and chronic inflammatory recurrent bacterial, viral and fungal infections of the oral cavity, paranasal sinuses, upper respiratory tract, inner and middle ear.
In a group of immunocompromised adolescents and adults in the form of monotherapy (sublingual):
prevention of influenza and other acute respiratory infections in the pre-epidemic period.
Correction of immune deficiency in adults and children.
In adults in complex therapy(6 mg):
chronic recurrent inflammatory diseases of any etiology that are not amenable to standard therapy, both in the acute stage and in the remission stage;
rheumatoid arthritis treated for a long time with immunosuppressants; or complicated by the occurrence of acute respiratory infections or acute respiratory viral infections;
acute and chronic viral and bacterial infections (including urogenital infectious and inflammatory diseases);
tuberculosis;
acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by chronic recurrent bacterial and viral infections;
during and after chemotherapy and radiation therapy of tumors; to reduce the nephro- and hepatotoxic effects of drugs;
to activate regenerative processes (fractures, burns, trophic ulcers).
As monotherapy
for the prevention of postoperative infectious complications;
correction of secondary immunodeficiencies resulting from aging or exposure to adverse factors;
prevention of influenza and acute respiratory infections.
In children from 6 months of age complex therapy(3 mg):
acute and chronic inflammatory diseases caused by pathogens of bacterial, viral, fungal infections (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, ARVI);
acute allergic and toxic-allergic conditions;
bronchial asthma complicated by chronic respiratory tract infections;
atopic dermatitis complicated by purulent infection;
intestinal dysbiosis (in combination with specific therapy);
for the rehabilitation of frequently and long-term ill children;

Suppositories:
In adults and children over 6 years of age complex therapy(for correction of immune deficiency):
for chronic recurrent inflammatory diseases of any etiology that are not amenable to standard therapy, both in the acute stage and in the remission stage;
acute and chronic viral and bacterial infections (including urethritis, cystitis, chronic pyelonephritis in the latent stage and in the acute stage, prostatitis, chronic salpingoophoritis, endometritis, colpitis; diseases caused by the papilloma virus; cervical ectopia; dysplasia and leukoplakia) ;
various forms of tuberculosis;
allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by recurrent bacterial and viral infections;
rheumatoid arthritis, long-term treatment with immunosuppressants; or complicated by the occurrence of acute respiratory infections or acute respiratory viral infections;
to activate regenerative processes (fractures, burns, trophic ulcers);
for the rehabilitation of frequently and long-term ill people (more than 4–5 times a year)
during and after chemotherapy and radiation therapy of tumors;
to reduce the nephro- and hepatotoxic effects of drugs.
As monotherapy :
for seasonal prevention of exacerbations of chronic foci of infections, incl. in elderly people;
for the prevention of recurrent herpetic infections;
for the correction of secondary immunodeficiencies resulting from aging or exposure to adverse factors;
for the prevention of influenza and acute respiratory infections.

Contraindications

Increased individual sensitivity, pregnancy (no clinical experience of use).
Carefully- acute renal failure.
Additionally for the lyophilisate for the preparation of solution for injection and topical use: carefully- children under 6 months of age (clinical experience of use is limited).

Use during pregnancy and breastfeeding

Contraindicated during pregnancy.

Side effects

Possible pain at the injection site with intramuscular injection (lyophilisate for preparing solution for injection).

Interaction

Compatible with antibiotics, antiviral, antifungal and antihistamines, bronchodilators, corticosteroids, cytostatics and beta-agonists.

Directions for use and doses

Pills. Sublingually And inside, 20-30 minutes before meals. Adults in doses of 12 or 24 mg, adolescents in doses of 12 mg daily 1, 2 or 3 times a day, depending on the diagnosis and severity of the disease.
Sublingually at a dose of 12 mg:
In inflammatory processes of the oral cavity(bacterial, viral and fungal nature) - 2 times a day at intervals of 12 hours, for 10-14 days. For severe forms of herpetic and fungal infections of the oral cavity - 3 times a day at intervals of 8 hours for 15 days.
For chronic diseases of the paranasal sinuses and chronic otitis media- 2 times a day at intervals of 12 hours, for 5-10 days.
For chronic tonsillitis- 3 times a day at intervals of 8 hours for 10-15 days.
For chronic diseases of the upper respiratory tract- adults at a dose of 24 mg 2 times a day, adolescents at a dose of 12 mg 2 times a day, at intervals of 12 hours, for 10-14 days.
For the prevention of influenza and acute respiratory infections— for immunocompromised individuals who suffer from acute respiratory infections more than 4 times a year, Polyoxidonium is recommended in the pre-epidemic period for adults at a dose of 24 mg, for adolescents at a dose of 12 mg sublingually 2 times a day for 10-15 days.
Inside. For chronic diseases of the upper respiratory tract - adults at a dose of 24 mg 2 times a day, for adolescents at a dose of 12 mg 2 times a day, with an interval of 12 hours, for 10-14 days.
Lyophilisate for the preparation of solution for injection and topical use. V/m, IV, intranasally, sublingually. Methods of application are selected by the doctor depending on the diagnosis, severity of the disease, and age of the patient.
V/m or IV(drip). The drug is prescribed to adults in doses of 6-12 mg 1 time per day, daily, or every other day, or 1-2 times a week, depending on the diagnosis and severity of the disease.
For intramuscular administration, the contents of the ampoule or bottle are dissolved in 1.5-2 ml of 0.9% sodium chloride solution or water for injection. For intravenous (drip) administration, the drug is dissolved in 3 ml of 0.9% sodium chloride solution, Hemodez, Reopoliglucin or 5% dextrose solution, then sterilely transferred into a bottle with the indicated solutions with a volume of 200-400 ml.
The prepared solution for parenteral administration cannot be stored.
Recommended treatment regimens for adults
Parenterally:
6 mg daily for 3 days, then every other day with a total course of 5-10 injections.
6 mg every other day for 5 injections, then 2 times a week for a course of at least 10 injections.
For tuberculosis: 6 mg 2 times a week for a course of 10-20 injections.
For rheumatoid arthritis: 6 mg every other day - 5 injections, then 2 times a week for a course of at least 10 injections.
In patients with acute and chronic urogenital diseases: 6 mg every other day for a course of 10 injections in combination with chemotherapy.
For chronic recurrent herpes: 6 mg every other day for a course of 10 injections in combination with antiviral drugs, interferons and inducers of interferon synthesis.
For the treatment of complicated forms of allergic diseases: 6 mg, course of 5 injections - the first 2 injections daily, then every other day. For acute allergic and toxic-allergic conditions, administer 6-12 mg intravenously in combination with antiallergic drugs.
In cancer patients:
- before and during chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents, 6-12 mg every other day for a course of at least 10 injections;
- for the prevention of the immunosuppressive effect of the tumor, for the correction of immunodeficiency after chemotherapy and radiation therapy, after surgical removal of the tumor, long-term use of Polyoxidonium (from 2-3 months to 1 year) 6 mg 1-2 times a week is indicated.
In patients with acute renal failure, it is prescribed no more than 2 times a week.
Intranasally prescribed for the treatment of acute and chronic infections of the ENT organs, to enhance the regenerative processes of the mucous membranes, to prevent complications and relapses of diseases, to prevent influenza and acute respiratory infections: 1-3 drops in each nasal passage after 2-3 hours (at least 3- 4 times a day) for 5-10 days. A dose of 6 mg is dissolved in 1 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature (20 drops) and use the solution for 24 hours.
For children. Methods of application are selected by the doctor depending on the diagnosis, severity of the disease, age and body weight of the patient.
Parenterally (i/m or IV drip) at a dose of 0.1-0.15 mg/kg daily, every other day or 2 times a week for a course of 5-10 injections.
For intramuscular administration, the drug is dissolved in 1 ml of water for injection or 0.9% sodium chloride solution.
For intravenous drip administration, the drug is dissolved in 1.5-2 ml of a sterile 0.9% solution of sodium chloride, Polyglucin, Hemodez or 5% dextrose solution, sterilely transferred to a bottle with the indicated solutions with a volume of 150-250 ml.
Recommended treatment regimens for children
For acute inflammatory diseases: 0.1 mg/kg every other day for a course of 5-7 injections.
For chronic inflammatory diseases: 0.15 mg/kg 2 times a week for a course of up to 10 injections.
For acute allergic and toxic-allergic conditions: IV drip at a dose of 0.15 mg/kg in combination with antiallergic drugs.
For the treatment of complicated forms of allergic diseases in combination with basic therapy: IM 0.1 mg/kg in a course of 5 injections with an interval of 1-2 days.
Intranasally: daily at a daily dose of 0.15 mg/kg for 5-10 days.
The drug is administered intranasally, 1-3 drops into one nasal passage every 2-3 hours (at least 3-4 times a day).
To prepare a solution for intranasal and sublingual use, a dose of 3 mg is dissolved in 1 ml (20 drops), a dose of 6 mg is dissolved in 2 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature. 1 drop of the prepared solution (50 μl) contains 0.15 mg of Polyoxidonium, which is prescribed per 1 kg of child’s body weight.
Calculation of daily dose for children
Sublingual: for all indications - daily at a daily dose of 0.15 mg/kg for 10 days, for the treatment of intestinal dysbiosis for 10-20 days.
Suppositories. Rectally(after bowel cleansing), intravaginally. The method of administration and dosage regimen are determined by the doctor depending on the diagnosis, severity and severity of the process.
Polyoxidonium can be used daily, every other day or 2 times a week.
Polyoxidonium suppositories 12 mg are used rectally and intravaginally in adults.
Rectally: 1 supp once a day (after cleansing the intestines).
Intravaginally: The suppository is inserted into the vagina in the “lying” position once a day, at night.
Polyoxidonium suppositories 6 mg are used: in adults - rectally and intravaginally as a maintenance dose; in children over 6 years of age - rectally at the rate of 0.20-0.25 mg/kg.
Standard scheme use of Polyoxidonium - 1 supp. 6 or 12 mg for 3 days, and then once every 2 days with a course of 10-15 supp. If necessary, the course of treatment is repeated after 3-4 months.
Patients with chronic immune deficiency (including cancer) are prescribed long-term (from 2-3 months to 1 year) maintenance therapy with Polyoxidonium: adults - 6-12 mg, children over 6 years - 6 mg 2 times a week.
Recommended regimens and doses
Included complex therapy. Rectally.
For chronic recurrent inflammatory diseases in the acute stage- according to the standard scheme, in the remission stage - 1 supp. 12 mg every 1-2 days, with a total course of 10-15 supp.
In acute infectious processes— 1 sup. daily, with a general course of 10 injections.
For tuberculosis- according to the standard scheme. The course of treatment is at least 15 supp., then it is possible to use maintenance therapy of 2 supp. per week for a course of 2-3 months.
For allergic diseases complicated by recurrent bacterial and viral infections,- according to the standard scheme.
During and after chemotherapy and radiation therapy of tumors- 1 sup. daily 2-3 days before the start of therapy. Further, the frequency of administration of suppositories is determined by the doctor depending on the nature and duration of basic therapy.
To reduce the nephro- and hepatotoxic effects of drugs. The duration and regimen of suppositories is determined by the doctor depending on the basic therapy.
For the correction of secondary immunodeficiencies resulting from aging- 12 mg 2 times a week. Course - 10 supp.
For rehabilitation of frequent (more than 4-5 times a year) and long-term ill persons— 1 sup. in one day. Course of treatment - 10 supp.
For rheumatoid arthritis treated with immunosuppressants for a long time,— 1 sup. every other day with a total course of 15 injections; in cases of rheumatoid arthritis complicated by acute respiratory infections or acute respiratory viral infections- according to the standard scheme.
To activate regenerative processes (fractures, burns, trophic ulcers)- daily 1 sup. The course of treatment is 10-15 supp.
As monotherapy:
For seasonal prevention of exacerbations of chronic foci of infections, for the prevention of recurrent herpetic infections- every other day for adults - 6-12 mg, for children - 6 mg. Course - 10 supp.
For the correction of secondary immunodeficiencies, prevention of influenza and acute respiratory infections- according to the standard scheme.
For gynecological diseases (rectal or intravaginal)— 1 sup. (12 mg) for 3 days, and then 1 time every 2-3 days. The course of treatment is 10-15 sup.

In this medical article you can familiarize yourself with the drug Polyoxidonium. The instructions for use will explain in what cases you can take suppositories, injections or tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Polyoxidonium, from which one can find out whether the medicine has helped in the treatment of immunodeficiencies and related infectious diseases in adults and children, for which it is also prescribed. The instructions list analogues of Polyoxidonium, prices of the drug in pharmacies, as well as its use during pregnancy.

An immunostimulating agent that increases the body's resistance to local and generalized infections is Polyoxidonium. Instructions for use prescribe the use of 12 mg tablets, 6 mg and 12 mg suppositories, injections in 3 mg and 6 mg injection ampoules to increase the body's resistance to infectious pathologies.

Release form and composition

The following dosage forms of Polyoxidonium are produced:

• Tablets 12 mg.
• Suppositories for vaginal or rectal use 6 mg and 12 mg.
• Lyophilisate for the preparation of a solution for injection and local use (injections in ampoules) 3 mg and 6 mg.

Active ingredient – ​​azoximer bromide (polyoxidonium):

• bottle of lyophilisate – 3 mg or 6 mg;
• tablet – 12 mg;
• suppository – 6 mg or 12 mg.

pharmachologic effect

The drug Polyoxidonium helps restore the immune status in secondary immunodeficiency conditions, which are caused by various types of infections, injuries, burns, malignant tumors, complications after surgical interventions, treatment with chemotherapy drugs, including cytostatic agents and steroid hormones.

Along with the immunocorrective effect of azoximer, bromide also has a pronounced detoxifying effect, which is due to the structure and high-molecular nature of this substance.

The result of its effect on the body is an increase in the resistance of cell membranes to the cytotoxic (causing damage to cells up to their death) action of drugs and chemicals, as well as a decrease in the toxicity of the latter.

Prescribing Polyoxidonium in combination with other drugs significantly increases the effectiveness of therapy, shortens its duration, allows you to reduce doses or completely avoid the use of antibiotics, bronchodilators and glucocorticosteroids, and helps to increase the period of remission (that is, the period of weakening or complete disappearance of the symptoms of the disease).

The medication is well tolerated by patients, does not exhibit mitogenic or polyclonal activity, does not have antigenic properties, does not provoke the development of allergies, mutations and other defects in fetal development, does not have a teratogenic effect on the developing fetus, and does not have carcinogenic or embryotoxic properties.

Why is Polyoxidonium prescribed?

Indications for use of the drug include correction of immunity in adults and children from 6 months of age.

What does it help children with? In complex therapy, pediatricians prescribe the drug:

• intestinal dysbiosis (in combination with specific therapy);
• atopic dermatitis complicated by purulent infection;
• prevention of influenza and acute respiratory infections;
• acute and chronic inflammatory diseases caused by pathogens of bacterial, viral, fungal infections (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, ARVI);
• for the rehabilitation of those who are often and long-term ill;
• acute allergic and toxic-allergic conditions;
• bronchial asthma complicated by chronic respiratory tract infections.

In adults in complex therapy:

• acute and chronic viral and bacterial infections (including urogenital infectious and inflammatory diseases);
• with rheumatoid arthritis complicated by acute respiratory infections;
• to activate regenerative processes (fractures, burns, trophic ulcers);
• for the prevention of influenza and acute respiratory infections;
• for the prevention of postoperative infectious complications;
• chronic recurrent infectious and inflammatory diseases that are not amenable to standard therapy in the acute stage and in remission;
• tuberculosis;
• in oncology during and after chemotherapy and radiation therapy to reduce the immunosuppressive, nephro- and hepatotoxic effects of drugs;
• acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by chronic recurrent bacterial and viral infections;
• rheumatoid arthritis.

Contraindications

The use of Polyoxidonium is contraindicated in patients with hypersensitivity to the components of the drug. Azoximer bromide should be used with caution when treating patients with acute renal failure. Lyophilisate and suppositories should not be prescribed during pregnancy and breastfeeding.

• Lyophilisate: up to 6 months - with caution.
• Tablets: up to 12 years.
• Candles: for children under 6 years old.

Instructions for use

Pills

Polyoxidonium instructions for use prescribe taking it orally or sublingually. It is recommended to take half an hour before meals twice a day. Children over 10 years of age and adult patients are prescribed one tablet. Children 3-10 years old are prescribed ½ tablet. If necessary and according to the doctor’s instructions, the course of treatment can be repeated after 3-4 months.

Sublingual tablets

Dosage for the treatment of adult patients and children over 10 years of age:

• Exacerbation of chronic diseases of the upper respiratory system and otitis is prescribed 1 tablet twice a day for 10 days, for patients 10-18 years old - the duration of therapy is 7 days.
• For the treatment of allergic diseases complicated by fungal, viral or bacterial infections, the recommended dose is 1 tablet. twice a day for 10 days, and for children 10-18 years old - for a week.
• Flu and ARVI - 1 tablet twice a day for a week.
• Inflammatory lesions of the oropharynx - 1 tablet. twice a day for 10 days, for children 10-18 years old for 7 days.
• For the treatment of the above diseases in children, ½ tablet is used. twice a day for a week.

Disease prevention:

• Secondary immunodeficiencies: adults – 1 tablet per day for 10 days.
• ARVI and influenza: adults – 1 tablet. per day for 10 days; children 3-10 years old – ½ tab. per day for a week.
• Herpes of the nasal and labial area: adults – 1 tablet. twice a day for 10 days; children 3-10 years old – ½ table. twice a day for 7 days.
• Exacerbation of chronic infectious diseases of the ear, oropharynx and upper respiratory organs: adults: 1 table. per day for 10 days; children 3-10 years old – ½ tablet, course of treatment – ​​10 days.

Oral administration of tablets

The drug is taken to treat children over 10 years of age and adult patients. The recommended dosage is 1 tablet twice a day for 10 days.

Suppositories Polyoxidonium

Suppositories 12 mg and 6 mg are administered rectally, after the bowel cleansing procedure, once a day (before bedtime). A single dose is one suppository. The scheme of their administration is as follows: daily, one at a time in the first 3 days, then - also one at a time - after 2 days. A full course requires 10 suppositories.

Intravaginal use is indicated for the treatment of gynecological diseases: dysplasia, erosion, cervical lekoplakia, colpitis, adnexitis, endometritis, as well as diseases provoked by human papillomavirus (HPV).

Treatment involves daily administration of one suppository for three days with a dosage of the active substance of 12 mg, after which the suppositories continue to be administered every other day. The course is carried out using 10 suppositories. In cases where it is appropriate, the course of treatment can be repeated after 3-4 months.

For patients diagnosed with chronic immune deficiency (including patients in whom such a condition was the result of cancer), Polyoxidonium is prescribed as a maintenance agent in a dose of 6 or 12 mg (according to the doctor’s indications) 1-2 times a week. The treatment is long-term.

Lyophilisate

Injections in ampoules are intended for parenteral (intramuscular (IM) or intravenous (IV)), intranasal and sublingual administration in children. Rules for preparing the solution:

IM administration: for adults – dissolve the contents of 1 bottle (6 mg) in 1.5-2 ml of water for injection or 0.9% sodium chloride solution; for children – dissolve 3 mg of the drug in 1 ml of 0.9% sodium chloride solution or water for injection;

IV drip administration: for adults - the contents of 1 bottle (6 mg) are dissolved in 2 ml of a 5% dextrose solution, 0.9% sodium chloride solution, hemodez-N or rheopolyglucin, then mixed with the selected solution in a volume of 200-400 ml; for children - dissolve 3 mg in 1.5-2 ml of 0.9% sodium chloride solution, hemodez-N, rheopolyglucin or 5% dextrose solution, then transfer the resulting solution into a bottle with 150-250 ml of the selected solution;

Intranasal administration: for adults – the contents of 1 bottle (6 mg), for children – ½ bottle (3 mg), should be dissolved in 1 ml of 0.9% sodium chloride solution, distilled or boiled water at room temperature.

One drop of the resulting solution for intranasal administration in children contains 0.15 mg of azoximer bromide. This solution is also used for sublingual use; it can be stored for no more than 7 days in the refrigerator; before use, the pipette is warmed to room temperature.

A solution for parenteral administration should be prepared before direct use. The route of administration and dose is determined by the doctor based on clinical indications, taking into account the patient’s age. Recommended dosage for parenteral administration:

• Tuberculosis: 6-12 mg 2 times a week, course of treatment – ​​10-20 injections;
• Correction of immunodeficiency after surgical removal of a tumor, radiation and chemotherapy, prevention of immunosuppressive effects: 6-12 mg 1-2 times a week for a long period. In case of acute renal failure, the drug should be administered no more than 2 times a week.
• Acute inflammatory pathologies: adults – 6 mg per day for 3 days, then – once every 2 days, a total of 5-10 injections; children – at the rate of 0.1 mg per 1 kg of child’s weight per day, the procedure is carried out every other day, a total of 5-7 injections;
• Rheumatoid arthritis: 6 mg every other day - 5 injections, then 2 times a week, for a total of at least 10 injections;
• Acute and chronic urogenital pathologies: 6 mg every other day, a total of 10 injections in combination with chemotherapy; Chronic recurrent herpes: 6 mg every other day, course of therapy - 10 injections with simultaneous administration of antiviral agents, interferons and inducers of interferon synthesis;
• Chemotherapy for oncological pathologies: 6-12 mg every other day, course - at least 10 injections, then the frequency of administration is prescribed individually, taking into account the tolerability and duration of radiation and chemotherapy;
• Complicated forms of allergic diseases: adults – 6 mg 1 time per day for 2 days, then every other day, a total of 5 injections; children - 0.1 mg intramuscularly per 1 kg of body weight per day after 1-2 days, a total of 5 injections in combination with basic therapy;
• Inflammatory diseases of chronic origin: adults – 6 mg 1 time per day every other day (5 injections), then – 2 times a week, course of treatment – ​​at least 10 injections; children - 0.15 mg per 1 kg of weight every 3 days, course of treatment - up to 10 injections;
• Acute allergic and toxic-allergic conditions (iv in combination with antiallergic drugs): adults - 6-12 mg, children - 0.15 mg per 1 kg of weight;

Recommended dosage for intranasal administration:

• Adults: 3 drops in each nasal passage 3 times a day for 5-10 days;
• Children: 1-3 drops in one nasal passage 2-4 times a day.

Sublingual administration of the solution to children (for all indications): 0.15 mg per 1 kg of body weight per day for 10 days, and for intestinal dysbiosis - 10-20 days.

Side effects

The use of lyophilisate may cause pain at the injection site.

Children, pregnancy and breastfeeding

The drug is contraindicated for use during pregnancy and breastfeeding. Experimental studies on animals have not revealed a negative effect of Polyoxidonium on the fertility of females and males.

Also, no teratogenic or embryotoxic effects of the drug or its effect on fetal development were detected throughout pregnancy and during lactation.

special instructions

For suppositories and tablets.

The patient should be aware that the duration of the course of therapy and the indicated doses should not be exceeded without prior consultation with the attending physician.

For lyophilisate for the preparation of injection solution.

If there is pain at the injection site during intramuscular administration, Polyoxidonium is dissolved in 1 ml of 0.25% procaine solution (provided the patient does not have hypersensitivity to procaine). For intravenous (drip) administration, the lyophilisate is not recommended to be dissolved in protein-containing infusion solutions.

All dosage forms are compatible with antiviral, antibiotics, antihistamines and antifungals, corticosteroids, bronchodilators, and cytostatics. The drug does not affect the ability to control complex mechanisms and drive a car.

Drug interactions

Polyoxidonium can be used in combination with antibiotics, antiviral and antihistamines, antimycotics, cytostatic, glucocorticosteroid and bronchodilator drugs, β-adrenergic stimulants.

If it is necessary to administer the solution by drop method into a vein, it should not be diluted with infusion solutions that contain proteins.

Analogues of the drug Polyoxidonium

Analogues of the drug by mechanism of action:

1. Broncho-Vaxom.
2. Affinoleukin.
3. Arpeflu.
4. Neuroferon.
5. Actinolysate.
6. Florexil.
7. Glutaxim.
8. Wilosen.
9. Anaferon.
10. Ribomunyl.
11. Engystol.
12. Immunofan.
13. Immunal.
14. Ismigen.
15. Cycloferon.
16. Taktivin.
17. Gerbion.
18. Cytovir-3.
19. Gepon.
20. Bioaron.
21. Polymuramyl.
22. Bestin.
23. Isophone.
24. Arpetolide.

Vacation conditions and price

The average price of Polyoxidonium (12 mg tablets No. 10) in Moscow is 570 – 765 rubles. Vaginal and rectal suppositories 6 mg (10 pieces per package) can be purchased for 795–910 rubles, injections — 665–755 rubles. In Kyiv you can buy medicine for 16 hryvnia, in Kazakhstan - for 245 tenge.

In Minsk, pharmacies offer the drug for 2 bel. ruble Sold according to prescription. Tablets and suppositories are classified as over-the-counter drugs; a prescription is required to purchase the lyophilisate.

Polyoxidonium- a drug that has pronounced immunomodulatory properties and is capable of increasing the body's resistance to generalized and local infections. Has detoxifying ability.

Polyoxidonium: composition and release form

1 ampoule or bottle of Polyoxidonium contains 3 or 6 g of polyoxidonium, 1 suppository of the drug contains 3 mg, 6 mg, 12 mg of polyoxidonium.

Polyoxidonium is produced in the form of a specific lyophilized porous mass, which is packaged in ampoules or vials and is used to prepare an injection solution. Polyoxidonium suppositories (suppositories) are available in 10 pieces per package.

In addition, there is another form of release of the drug - in tablets.

Polyoxidonium: properties and functions

The immunomodulator Polyoxidonium, reviews of which are mostly positive, has proven itself not only in monotherapy, but also in complex treatment. This reduces treatment time and affects its effectiveness. This drug has the following main properties:

To achieve a positive result in the treatment of certain diseases, Polyoxidonium suppositories are used. As part of complex therapy, Polyoxidonium should be taken:

If there are any inflammatory processes in the body;
- with rheumatoid arthritis or rheumatism complicated by ARVI or acute respiratory infections;
- in the presence of bacterial and viral infections in the genitourinary system (cystitis, prostatitis, chronic pyelonephritis, colpitis, cervical ectopia);
- for tuberculosis of various locations;
- in acute forms of allergic diseases;
- in the treatment of oncology, to minimize the side effects of chemotherapy and radiation therapy;
- to activate regenerative processes in the body;
- for HIV infection;
- to prevent the occurrence of various infections in older people.

Polyoxidonium: contraindications

This drug is contraindicated for use in people with hypersensitivity to the components included in its composition. The use of Polyoxidonium is not recommended for women during pregnancy and lactation, with renal failure and age under 6 months are sufficient factors to prohibit the use of this drug.

Polyoxidonium: instructions for use of tablets

For the tablet form of the drug, oral or sublingual (under the tongue) administration is prescribed 20-30 minutes before meals, twice a day: children aged 3-10 years - half a tablet (6 mg), children over 10 years old, adults - 1 tablet (12 mg). Repeated courses of admission can be carried out after 90-120 days.

Sublingual regimens

For adults for medicinal purposes:

• For influenza, ARVI - 1 tablet twice a day for a 7-day course.
• In case of allergies, concomitant infectious relapses, inflammation of the oral cavity, chronic otitis media, exacerbation of sinusitis, the course is extended to ten days.

• Secondary immunodeficiencies, influenza, acute respiratory viral infections - 1 tablet per day for a 10-day course.
• Recurrent herpes - 1 tablet twice a day for 10 days.
• For exacerbations of respiratory system infections - 1 tablet daily (course - 10 days).

For children 3-10 years old for medicinal purposes:

• For influenza, ARVI, allergies complicated by infectious relapses - 0.5 tablets 2 times a day for a 7-day course.

For children 3-10 years old as part of prevention:

• ARVI, influenza - half a tablet per day for a 7-day course.
• Recurrent herpes - half a tablet twice a day (course - one week).
• For exacerbations of diseases affecting the respiratory system - half a tablet per day (course - 10 days).

For children over 10 years of age for medicinal purposes:

• For allergies complicated by infectious relapses, acute respiratory viral infections, influenza, inflammation of the nasopharynx - one tablet twice a day for a 7-day course.
• For exacerbations of pathologies of the respiratory system - one tablet twice a day (course - one week).

For children over 10 years of age as part of prevention:

• Exacerbations of infections and respiratory diseases - 1 tablet daily (course - 10 days).
• ARVI, influenza - one tablet per day for a 7-day course.
• Herpes (recurrences) - one tablet 2 times a day for one week.

Oral dosage regimens for the treatment of respiratory diseases: one tablet 2 times a day for a 10-day course (contraindication to therapy according to this regimen is age under 10 years).

Instructions for use of suppositories

General recommendations: vaginal or rectal administration once a day (daily, every other day, once every 3 or 4 days). Rectal administration is carried out after cleansing the intestines, vaginal - in a lying position, after hygiene procedures before going to bed.

For adults during treatment:

• Gynecological diseases - 1 supp. 12 mg daily, after the third supp. - every other day (general course - 10 supp.).
• Rheumatoid arthritis - 1 sup. 12 mg 1 time every two days (course - 10 supp.).
• Allergies, infectious, urological exacerbations, trophic ulcers, burns, fractures - 1 sup. 12 mg 1 time per day every day (course - 10 supp.).
• Infectious exacerbations - 1 sup. 12 mg daily, after the third supp. - every other day (general course - 10 supp.).
• Pulmonary tuberculosis - 1 sup. 12 mg daily, after the third supp. - every other day (general course - 20 supp.). Maintenance treatment - 1 supp. 6 mg twice a week for a 9-13 week course.
• Oncology, radiation, chemical therapy - 1 supp. 12 mg daily 2-3 days before the start of the treatment course, then 1 supp. 12 mg 2 times a week (general course - 20 supp.).

For adults as part of prevention:

• Secondary age-related immunodeficiency disorders - 1 supp. 12 mg twice a week (general course - 10 supp.). The frequency of courses is two to three times a year.
• Viral respiratory diseases, influenza - 1 sup. 12 mg 1 time per day (general course - 10 supp.).
• Recurrent herpes affecting the urogenital organs - 1 supp. 12 mg every other day (general course - 10 supp.).

Rectal use for children 6-18 years of age for treatment:

• ARVI, influenza, fractures, burns, trophic ulcers, exacerbations of urological ailments, allergies - 1 supp. 6 mg daily for a 10-day course.
• Exacerbations of chronic infections - 1 sup. 6 mg daily, after the third supp. - every other day (course - 10 supp.).
• Rheumatoid arthritis - 1 sup. 6 mg every other day (course - 10 supp.).
• Pulmonary tuberculosis - 1 sup. 6 mg 1 time per day every day, after the 3rd supp. - every other day (course - 20 supp.). Course of maintenance therapy - 1 supp. 6 mg twice a week (course duration - up to 2-3 months).
• Oncological pathologies and courses of anticancer therapy - 1 sup. 6 mg daily 2-3 days before the start of the treatment course, then 1 supp. 6 mg 2 times a week (total - up to 20 supp.)

Rectally - for children 6-18 years old as part of anti-infective, anti-herpetic preventive measures - 1 supp. 6 mg every other day (general course - 10 supp.).

In case of long-term immunosuppressive treatment, the presence of oncology, HIV, maintenance treatment is organized (course - from 7-13 weeks to a year): adults - 12 mg, children from 6 years - 6 mg, frequency of use - 1-2 times a week.

Polyoxidonium: price and sale

Polyoxidonium is a very common drug because it is very well known. You can buy Polyoxidonium in an online pharmacy, and it is also on the list of drugs that can be purchased at any pharmacy. Advice regarding the purchase of the drug consists of the following warning - you should not take risks and purchase this drug, as well as other medications, from your hands or through friends. To eliminate the risk of purchasing a counterfeit, it is better to buy Polyoxidonium in official medical institutions where a certificate is available indicating the quality of the product. Polyoxidonium, the price of which is the same almost everywhere, is a completely affordable drug.

The drug Polyoxidonium, reviews of which are mostly positive, still has some contraindications. Therefore, you should take the drug only after the approval of your doctor.

Polyoxidonium and Transfer Factor

Polyoxidonium, the price of which is about 1000
rubles for 10 suppositories, respectively, the full course will require approximately 3,000 rubles, since the course of treatment involves taking about 30 suppositories. In order to achieve results, this therapeutic course may have to be repeated several times. Transfer factor, which performs the same functions, costs about 2000 per pack of 90 capsules, has no contraindications and has no adverse reactions. In addition, its effect on the body is far superior to that of other drugs known to medicine today. Transfer factor eliminates damage in the DNA chain itself and supplies the immune system with the necessary information, while eliminating the very cause of the disease. It is very effective to use Transfer Factor together with other drugs, including Polyoxidonium, since this is the person’s choice, because Transfer Factor has the ability to neutralize all the side effects of other medications and improve all immune processes in the body.