Kestin: main characteristics, composition and customer reviews. Kestin - methods of use and dosage, how effective the treatment is, reviews Interaction with other drugs and alcohol

To effectively combat allergies and their manifestations, many medications have been developed, the therapeutic effect of which is to block histamine H1 receptors. The second-generation antiallergic drug "Kestin" (international nonproprietary name - ebastine) belongs to the middle price category.

Since the active ingredient ebastine is contained only in Kestin, there are no analogues of this drug similar in structure to it. In different countries, ebastine is produced under various names, including Aleva, Ebastine, Ebatrol, Evastin, Kestine and others. The drug has good reviews.

"Kestin": instructions for use

Pharmacological action and pharmacokinetics

"Kestin" carries out a competitive blockade H1 receptors of the neurotransmitter histamine, resulting in reduced vascular permeability and the risk of spasm of bronchial smooth muscles. The drug has a long-lasting effect, which manifests itself an hour after administration and lasts two days.

Absorption occurs immediately after ingestion. In the liver, the active substance is converted into the metabolite carebastine. The absorption and formation of carebastine can be accelerated by eating fatty foods.

During treatment with Kestin, a gradual accumulation of carebastine occurs in the body, so at the end of the course therapeutic effect is maintained for another six days. With continuous use of the drug for three days, the equilibrium concentration of the metabolite is established in the range of 130–160 ng/ml. The drug has no sedative effect.

The drug is excreted from the body by the kidneys. Half of the pharmacological effect is lost after 15–19 hours; in case of liver and kidney failure, this figure can reach 27 and 23–26 hours, respectively.

Release form

"Kestin" is presented in the following forms:

White tablets or almost white in a film shell. The concentration of the active substance in the tablet is 10 or 20 mg. Ingredients: ebastine, cellulose, starch, magnesium stearate, lactose monohydrate, croscarmellose sodium, titanium dioxide. The tablets are engraved “E10” or “E20” on one side.
Lyophilized tablets(instant) for resorption. Ingredients: ebastine (10 mg), gelatin, mannitol, aspartame sweetener, mint flavor.
Clear syrup with anise flavor. Supplied in a dark glass bottle with an aluminum cap and a measuring syringe included. Syrup composition: ebastine, glycerin, sorbitol solution, glycerol oxystearate, lactic acid, sodium methyl parahydroxybenzoate, water, other substances in a concentration of less than 1 mg, acidity regulator.

Indications for use

"Kestin" is prescribed for the following conditions:

allergic rhinitis of various origins,
allergic conjunctivitis,
urticaria of various origins,
Quincke's edema,
other diseases caused by high concentrations of histamine.

Contraindications

You should avoid taking Kestin if you are highly sensitive to its components, as well as during pregnancy. Tests of the drug on animals have confirmed the harmlessness of ebastine to the fetus, but there is currently no data on this kind of effect on the human body. It is also unknown whether ebastine and its metabolite carebastine are excreted in breast milk, so the drug should not be used by nursing mothers.

The medicine is contraindicated in people with lactase deficiency, lactose intolerance and glucose-galactose malabsorption.

Some forms of "Kestin" ( oral tablets) is not prescribed for protein metabolism disorders. Lyophilized tablets are contraindicated for children and adolescents under 15 years of age, coated tablets are contraindicated for children under 12 years of age. The use of the drug is not recommended for children under six years of age.

Patients with hypokalemia, hepatic or renal failure and an increased QT interval should take Kestin with caution.

Side effects

At therapeutic doses, the drug causes few side effects. Sometimes its use leads to drowsiness, headache and dry mouth. Isolated cases of sinusitis and rhinitis have been reported, as well as nausea, abdominal pain and sleep disturbance.

The drug does not have a negative effect on the central nervous system, so patients are allowed to engage in activities that require high concentration: for example, driving a car.

An overdose, in which the patient feels fatigue and dry mouth, can only be caused by simultaneous intake of at least a thirty-fold dose of Kestin. Since there is no drug that could weaken or neutralize the effect of ebastine, in case of overdose it is necessary to cleanse the stomach and treat individual symptoms.

Mode of application

Kestin is taken orally once a day. Meal times don't matter. The medicine does not need to be taken with water. The dosage differs for children and adults:

The maximum daily dose of the drug for the treatment of patients with liver dysfunction is 10 mg.

Lyophilized tablets are designed to be dissolved in the mouth. They do not have a shell and are generally quite fragile, so they should be removed from the blister carefully, without pressing.

Interaction with other drugs

fluconazole, ketoconazole and other antifungal agents,
erythromycin, roxithromycin and other macrolides (increase the risk of prolongation of the QT interval).

No interactions have been identified with the following drugs:

indirect anticoagulants,
theophylline,
cimetidine,
tranquilizer diazepam,
alcohol and alcohol-containing drugs.

Where can I buy Kestin?

Antihistamines are usually sold in pharmacies without a prescription; “Kestin” is no exception. Prices for the drug depend on the form of release: tablets containing 10 mg ebastine, produced in quantities of 5 pieces. in a package, they cost a little more than 250 rubles - this is enough for one course of treatment. However, for frequent use and in severe cases of the disease, it is more profitable to choose packages of 10 tablets containing 10 and 20 mg of the active substance.

How to replace the drug "Kestin"?

On a trip abroad

If a drug with the familiar name Kestine is not available in a foreign pharmacy, you should look for other medications that have the international nonproprietary name ebastine. The instructions for use of these medications are the same as for Kestin, since they are essentially synonymous drugs. List of some ebastine-based medications:

Egypt: Bastab, Evastine.
Spain: Alastina, Ebastina Combix.
Italy: Clever.
India: Ebast, Erostin.
Netherlands: Lacinet, Netan, Notaxo, Stibal.
Philippines: Co-Aleva, Histagone.
Finland: Kestine Lyo.
China: Si Jin, Su Di.
Japan: Ebastine Choseido.

In case of intolerance to components

Any H1 receptor blocker of the histamine neurotransmitter is suitable to replace Kestin. When selecting an analogue, you need to pay attention to the generation. It is recommended to use second-generation analogues (loratadine, cetirizine) or their active metabolites of the third and fourth generations. They relieve allergies more effectively and have fewer side effects. These drugs include desloratadine and levocetirizine.

If taking Kestin is impossible for any reason, be it being in another country, individual intolerance to the auxiliary components or active substance, childhood or old age, pregnancy, you can find a worthy replacement. In this case, it is best to entrust the selection of a similar drug to a specialist.

Kestin is capable of influencing H1 type histamine receptors via competitive inhibition.

Ebastine does not displace histamine from connections with receptors, but binds to free receptors.

This helps stop the development of an allergic reaction.

The drug is effective as a prophylactic against allergic reactions.

As a result of a decrease in the influence of histamine on receptors, a decrease in the intensity of bronchospasm, a decrease in pathological capillary permeability and tissue swelling are observed.

Kestin has an antiallergic, antihistamine effect and may have a sedative effect on the patient.

Indications and dosage:

Kestin is indicated for:

Seasonal allergic rhinitis

Renitis associated with household allergens, pollen, drugs

Food allergies

Allergies to epidermal particles

Hives caused by any type of allergen

Conditions caused by increased histamine production

For adults and children over 15 years of age, the drug is prescribed 10-20 mg (1/2-1 tablet) 1 time/day.

Children aged 12 to 15 years - 10 mg (1/2 tablet) 1 time / day.

In patients with impaired liver function, the daily dose should not exceed 10 mg.

The drug is taken regardless of meals.

In pediatrics and in cases of difficulty swallowing tablets, it is preferable to use Kestin syrup.

If you have an individual reaction to the drug with the appearance of drowsiness, you should stop driving and postpone engaging in hazardous activities.

Overdose:

Exceeding the dosage of ebastine may be accompanied by increased unwanted side effects.

There is no specific antidote.

Adsorbents are prescribed, gastric lavage is prescribed, and the patient is admitted to a medical facility to monitor the condition and carry out symptomatic therapy.

Side effects:

Taking Kestin may be accompanied by:

Drowsiness

Dry mouth

Headache

Nausea

Dyspepsia

Asthenic syndrome

Insomnia

Epigastric pain

Sinusitis

Contraindications:

Kestin is not prescribed for:

Lactation

Hypersensitivity to ebastine, tablet components

Pregnancy

Indications for children under 6 years of age

In case of renal failure, prolongation of the QT interval, disorders of hepatic metabolism, hypokalemia, Kestin should be prescribed with caution.

There are no reliable data on the safety of clinical use of Kestin and its analogues during pregnancy.

Preparations containing ebastine are not prescribed to pregnant women.

Interaction with other drugs and alcohol:

The drug Kestin is incompatible with antifungal agents containing ketoconazole, as well as with erythromycin antibiotics.

No significant pharmacological interactions have been recorded with other drugs.

Composition and properties:

1 tablet of Kestin contains:

Ebastine micronized 0.01 g

Auxiliary components: MCC, starch, lactose, sodium CMC, magnesium stearate, HPMC, PEG-6000, titanium dioxide

5 ml of Kestin syrup contains:

Ebastine 0.005 g

Auxiliary components: α-hydroxypropionic acid, glycerin, glycerol oxystearate, sodium propylparaben, sodium methylparaben, sorbitol, neohesperidin dihydrochalcone, dimethylpolysiloxane, anethole, sodium hydroxide, prepared water

Release form:

Kestin is produced in tablet form and syrup form. The packaging is as follows:

5 tablets/1 blister/packaging

10 tablets/1 blister/packaging

Syrup 60 ml/glass bottle with dispenser syringe included/packaging

Syrup 120 ml / glass bottle with dispenser syringe included / packaging

Storage conditions:

The storage temperature for Kestin syrup is 15-25 degrees Celsius, for tablets – up to 30 degrees Celsius.

The drug Kestin should be kept during storage in a dry place, protected from sunlight.

Children's access to both tablets and syrup should be limited.

The shelf life of syrup is 2 years, Kestin tablets are 3 years.

general information

Sales form:

Today we will talk about Kestin, as one of the effective remedies for allergies. Or not effective? Let's figure it out.

Allergic diseases are currently observed in one form or another in a larger number of people on the planet.

Developing allergies significantly change a person’s well-being for the worse and negatively affect their ability to work and the acquisition of new knowledge.

Some complications of allergies are also dangerous for people, and therefore treatment of symptoms of intolerance to a certain irritant that arise constantly or periodically is always necessary.

The pharmacological industry is constantly developing and producing new antihistamine drugs, the latest group of which includes the drug Kestin.

The positive properties of the antihistamine Kestin have been assessed by a fairly large number of people with allergic reactions, and this allows us to assert that the medicine has the desired therapeutic activity.

Kestin - composition of the drug and mechanism of action

Kestine is available in two forms - tablets and syrup.

The tablet form of the drug is intended for patients over 12 years of age.

The syrup can be used to eliminate manifestations starting from the age of six.

Tablets are available in two types, that is, they can be film-coated or lyophilized.

Lyophilized tablets quickly develop their healing properties and begin to work when exposed to moisture.

The main active ingredient of the drug is ebastine, which is a histamine H1 receptor blocker; there is a drug with the same name, which is a complete analogue of Kestin.

Any allergic reaction in the body occurs with the formation of inflammatory mediators, which primarily include histamine.

Under the influence of this substance, all the signs of an allergic reaction develop, that is, tissue swelling occurs, the production of mucous secretion by cells increases, irritation appears, etc.

In order to achieve the disappearance of these symptoms, it is necessary to interrupt the production of inflammatory mediators, and antihistamines, according to their mechanism of action, are designed precisely for this.

Ebastine, which is part of Kestin, has pronounced antihistamine activity, its full effect occurs within one hour after administration.

The general course of treatment is determined by the cessation of signs of an allergic reaction.

In the treatment of some patients, a four-week course of therapy with this drug was prescribed and no significant side effects were noted.

How does Kestin differ from other antihistamines?

Currently, quite a lot of different products are produced aimed at eliminating allergies or preventing them.

It is quite difficult to select the most effective one and this can only be done correctly under the guidance of a doctor after completing all the studies.

The medicine Kestin must also be prescribed for use by an allergist and, first of all, it is prescribed for the treatment of:

Year-round or seasonal rhinitis that occurs under the influence of different groups of allergens;
Allergic conjunctivitis;
For Quincke's edema and urticaria. Allergic disease caused by physical factors, that is, direct, cold, overheating, can also be treated;
Any diseases that develop under the influence of histamine produced in the body.

Taking Kestin provides a rapid therapeutic effect; a noticeable reduction in symptoms is observed within one hour after taking the required therapeutic dose.

The medicine Kestin has a number of additional advantages:

The drug can be taken once a day, its therapeutic effect lasts for 48 hours;
For long-term treatment with Kestin, an intermittent treatment regimen is used. The medicine must be taken daily in the required dosage for 5 days, then take a break for two days. This use became possible due to the fact that with long-term use, ebastine accumulates in the body and then its therapeutic, antihistamine effect is expressed within 72 hours;
There is no need to take the medicine with water; the tablet dissolves easily and quickly in the mouth under the influence of salivary enzymes. Due to this, Kestin is convenient to use while traveling;
The drug does not affect the reaction rate and therefore treatment with it is possible when driving vehicles and other complex mechanisms.

When prescribing a medicine, the doctor must take into account the patient's use of other medications and select a treatment regimen accordingly.

How to use Kestin

Kestin can be used for medicinal purposes regardless of food intake; the medicine does not need to be washed down with water.

When opening the package, you must be careful, as the tablets are quite fragile and easily break under pressure.

Treatment begins with a dose of 10 mg; if the desired effect is not observed, then the dosage is increased to 20 mg per day.

Children from 12 to 15 years of age are treated only with a dose of 10 mg per day. The same dosage should be observed in patients with severe liver dysfunction.

In other cases, the drug is taken according to the usual regimen. It should also be taken into account that the use of Kestin is contraindicated in some cases.

The medicine is not prescribed:

Pregnant women and women breastfeeding. Clinical trials of this group of patients have not been conducted, and therefore doctors cannot say with certainty how ebastine will affect the development of the fetus;
The drug in tablets is not used until the child reaches the age of twelve.

In rare cases, patients experience headache, slight dizziness, dyspepsia, abdominal pain, drowsiness, or, conversely, insomnia.

If these changes are very disturbing and do not go away within a few days, the doctor may reduce the daily dose.

An overdose of the drug is reflected in changes in the functioning of the central nervous system; severe symptoms of poisoning occur when using Kestin in a dose of 300 mg, which is almost 15 times higher than a single dose.

There is no antidote for the drug, so in case of overdose, symptomatic therapy is used.

If you accidentally take several antihistamine tablets at once, you must rinse your stomach as quickly as possible.

Kestin and other groups of drugs

The antihistamine drug Kestin, produced in the form of film tablets, is incompatible:

With antifungal medications such as Fluconazole, Ketoconazole;
Antibiotics from the Macrolide group;
With a drug used in the treatment of asthma – Theophylline;
Indirect anticoagulants;
With the antiulcer drug Cimetidine;
With the drug Diazepam;
With medications manufactured using ethanol.

IT IS IMPORTANT TO KNOW : .

Lyophilized tablets are not prescribed simultaneously with Ketoconazole and Erythromycin, but can be used with those medications for which the use of film-coated tablets is contraindicated.

Lyophilized Kestin can also be consumed with moderate doses of alcohol.

When prescribing medication, the allergist must know what else his patient is being treated with. This will avoid unwanted reactions and increase the likelihood of the prescribed therapy being effective.

The drug is freely available in pharmacies; it can be stored under normal conditions, when the room temperature does not exceed 25 degrees.

Basic and frequently used analogues of Kestin

In cases where Kestin is contraindicated for any indication or when undesirable reactions occur during use, the doctor selects analogues, that is, drugs that have a similar mechanism of action.

The main analogues of Kestin include:

H1-histamine receptor blockers based on other active ingredients. These are drugs such as Fenistil, Diazolin, Diprazin, Semprex, Astelong, Supradin;
Mast cell membrane stabilizers - Intal, Lecrolin, Nedocromil Sodium. This group of drugs prevents the release of histamine and other mediators of allergic inflammation from mast cells.

Only a doctor should select analogues, just like Kestin himself.

Self-prescription almost never eliminates all manifestations of allergies and, moreover, can be complicated by other pathologies.

In this article you can read the instructions for use of the drug Kestin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Kestin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Kestin analogues in the presence of existing structural analogues. Use for the treatment of urticaria, rhinitis and other manifestations of allergies in adults, children, as well as during pregnancy and breastfeeding. Composition and interaction of the drug with alcohol.

Kestin- antiallergic drug. After taking the drug orally, a pronounced antiallergic effect begins within 1 hour and lasts for 48 hours. After a 5-day course of treatment with Kestin, antihistamine activity persists for 72 hours due to the action of active metabolites. The drug does not have a pronounced anticholinergic and sedative effect. There was no effect of the drug Kestin on the QT interval of the ECG at a dose of 100 mg, which exceeds the recommended daily dose by 5-10 times.

Compound

Ebastine + excipients.

Pharmacokinetics

After oral administration, it is quickly absorbed and almost completely metabolized in the liver, turning into the active metabolite carabastine. Fatty foods accelerate absorption (concentration in the blood increases to 50%). Eating does not affect the clinical effects of Kestin. Does not penetrate the blood-brain barrier. Excreted by the kidneys - 60-70%, in the form of conjugates.

Indications

allergic rhinitis, seasonal and/or year-round (caused by household, pollen, epidermal, food, drug allergens);
urticaria (can be caused by household, pollen, epidermal, food, insect, drug allergens, exposure to the sun, cold, etc.);
allergic diseases and conditions caused by increased release of histamine.

Release forms

Film-coated tablets 10 mg and 20 mg.

Lyophilized tablets 20 mg.

Syrup (sometimes mistakenly called drops).

Instructions for use and dosage regimen

Pills

Inside, regardless of food intake.

Adults and children over 12 years of age are prescribed 10-20 mg (1-2 tablets) of the drug once a day.

If liver function is impaired, the daily dose should not exceed 10 mg.

Lyophilized tablets

The drug is intended for absorption in the oral cavity, regardless of food intake.

Adults, children and adolescents over 15 years of age are prescribed 20 mg (1 lyophilized tablet) 1 time per day. The course of treatment is determined by the disappearance of symptoms of the disease.

In elderly patients, no dose adjustment is required.

In patients with impaired renal function, no dose adjustment is required.

For minor and moderate liver failure, the drug can be used in the usual dose. In case of severe liver dysfunction, the daily dose of ebastine should not exceed 10 mg.

Special precautions when handling the drug:

To avoid damaging the tablets, do not remove the tablet from the blister by pressing. Open the package by carefully lifting the free edge of the protective film.
Remove the protective film.
Carefully squeeze out the drug without touching it.

Carefully remove the tablet and place it on your tongue, where it will quickly dissolve. There is no need to drink water or other liquid. Eating does not affect the effect of the drug.

Syrup

Children from 6 to 12 years: 5 mg (5 ml) 1 time per day.
Children from 12 to 15 years: 10 mg (10 ml) 1 time per day.
Adults and children over 15 years of age are prescribed 10-20 mg (10-20 ml) 1 time per day.

Kestin is taken regardless of meals.

Side effect

headache;
drowsiness;
dryness of the oral mucosa;
dyspepsia;
nausea;
insomnia;
abdominal pain;
asthenic syndrome;
sinusitis;
rhinitis.

Contraindications

hypersensitivity to the components of the drug;
pregnancy, lactation period;
children up to 12 years of age (tablets), up to 15 years of age (lyophilized tablets);
lactase deficiency
lactose intolerance
glucose-galactose malabsorption.

Use during pregnancy and breastfeeding

Kestin is contraindicated during pregnancy and lactation.

Use in children

Tablets are contraindicated in children under 12 years of age. Lyophilized tablets are contraindicated in children under 15 years of age. The syrup is used with caution in children under 6 years of age.

special instructions

Use with caution in patients with an increased QT interval, hypokalemia, and renal and/or liver failure.

Impact on the ability to drive vehicles and operate machinery

In the event of side effects from the central nervous system, there may be a minimal decrease in the ability of patients to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Drug interactions

The drug Kestin does not interact with theophylline, indirect anticoagulants, cimetidine, diazepam, ethanol (alcohol) and ethanol-containing drugs.

Analogues of the drug Kestin

The drug Kestin has no structural analogues for the active substance. The drug contains the unique active ingredient Ebastine.

Analogs for therapeutic effect (medicines for the treatment of urticaria):

Allerfex;
Arthromax;
Asmoval;
Astemizole;
Berlicourt;
Hydrocortisone;
Histaglobin;
Gistalong;
Histaphen;
Decortin;
Dexamethasone;
Diazolin;
Diacin;
Dimebon;
Zaditen;
Zyrtec;
Zodak;
Calcium chloride;
Kenacort;
Clargothyl;
Claridol;
Claritin;
Clarifer;
Clemastine;
Xizal;
Lomilan;
Loratadine;
Lordestin;
Lorinden;
Lotharen;
Nobrassite;
NovoPassit;
Oxycort;
Parlazin;
Pipolfen;
Prednisolone;
Primalan;
Rivtagil;
Suprastin;
Suprastinex;
Tavegil;
Telfast;
Tranexam;
Fenistil;
Fenkarol;
Fortecortin;
Celeston;
Cetirizine;
Cetrin;
Erolyn.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Histamine is an essential substance that is predominantly found in mast cells of connective tissue and basophils in the blood. Released from these cells under the influence of various factors, it binds to the H1 and H2 receptors:

H1 receptors, when interacting with histamine, cause bronchospasm, contraction of smooth muscles, dilate capillaries and increase their permeability.
H 2 receptors stimulate an increase in acidity in the stomach and affect heart rate.

The active ingredient of the drug Kestin is ebastine. Contents in dosage forms:

1 film-coated tablet may contain 10 mg or 20 mg of ebastine;
1 lyophilized tablet contains 20 mg of ebastine;
1 ml of syrup contains 1 mg of ebastine.

Auxiliary components of film-coated tablets:

magnesium stearate;
lactose monohydrate;
hydroxypropyl methylcellulose;
corn starch;
microcrystalline cellulose;
structured sodium carboxymethylcellulose;
polyethylene glycol 6000.

Auxiliary elements of lyophilized tablets:

mannitol;
gelatin;
mint flavor;
aspartame.

Additional substances in syrup:

distilled water;
glycerol oxystearate;
70% sorbitol solution;
glycerol;
85% lactic acid;
dihydrochalcone neohesperidin;
sodium propyl parahydroxybenzoate;
sodium hydroxide;
dimethylpolysiloxane;
anethole

Kestin - composition of the drug and mechanism of action

Kestine is available in two forms - tablets and syrup.

The tablet form of the drug is intended for patients over 12 years of age.

The syrup can be used to eliminate allergy symptoms in children starting from the age of six.

Tablets are available in two types, that is, they can be film-coated or lyophilized.

Lyophilized tablets quickly develop their healing properties and begin to work when exposed to moisture.

The main active ingredient of the drug is ebastine, which is a histamine H1 receptor blocker; there is a drug with the same name Ebastine, which is a complete analogue of Kestin.

Any allergic reaction in the body occurs with the formation of inflammatory mediators, which primarily include histamine.

Additional information about the drug: review of analogues, use in children, pregnant women, etc.

To treat allergic manifestations in children, antihistamines of all three generations are used.

1st generation antihistamines are distinguished by the fact that they quickly exhibit their healing properties and are eliminated from the body. They are in demand for the treatment of acute manifestations of allergic reactions. They are prescribed in short courses. The most effective of this group are Tavegil, Suprastin, Diazolin, Fenkarol.

A significant percentage of side effects leads to a reduction in the use of these medications for childhood allergies.

2nd generation antihistamines do not cause a sedative effect, act for a longer time and are usually used once a day. Few side effects. Among the drugs in this group, Ketitofen, Fenistil, Cetrin, Erius are used to treat manifestations of childhood allergies.

The 3rd generation of antihistamines for children includes Gismanal, Terfen and others. They are used for chronic allergic processes, since they can remain in the body for a long time. There are no side effects.

1st generation: headache, constipation, tachycardia, drowsiness, dry mouth, blurred vision, urinary retention and lack of appetite; 2nd generation: negative effect on the heart and liver; 3rd generation: none, recommended for use from 3 years.

Antihistamines are produced for children in the form of ointments (allergic skin reactions), drops, syrups and tablets for oral administration.

Analogue drugs	Fenistil; Diazolin; Diphenhydramine; Suprastin; Tavegil; Zodak; Cetrin; Loratadine.
Analogues in homeopathy	Tablets, Luffel spray; Drops Edas-131 "Rinitol"; Drops Edas-130 "Allergopent".
Analogues in folk medicine	A decoction of string, bay leaf, burdock, dandelion, chamomile. Infusions of peony and celandine.
Use during pregnancy and lactation	Contraindicated.
Use of the drug in childhood	From 6 to 12 years old, 5 mg syrup per day is recommended; 12 – 15 years – 10 mg tablets – 1/2 tablet once a day.
Use of the drug in old age	As prescribed by a doctor.
Is it possible to drink alcohol?	Combined use is possible only with lyophilized tablets.
Can I drive after the appointment?	Can.
Expected improvement	1 hour after administration.
If the drug doesn't help	After 5 days of taking it, if there is no improvement, you should consult a doctor.

"Kestin" is a new generation antihistamine. Its distinctive features are the absence of a sedative effect on the body and an addictive effect. Kestin not only has a quick effect on allergens, but also an attractive price.

Dosage form

But 2nd generation antihistamines have a cardiotoxic effect of varying degrees, so when taking them, cardiac activity is monitored. They are contraindicated in elderly patients and patients suffering from disorders of the cardiovascular system.

These substances are prodrugs, which means that when they enter the body, they are converted from their original form into pharmacologically active metabolites.

All 3rd generation antihistamines do not have cardiotoxic or sedative effects, so they can be used by people whose activities involve high concentration.

These drugs block H1 receptors and also have an additional effect on allergic manifestations. They are highly selective, do not cross the blood-brain barrier, therefore they are not characterized by negative consequences from the central nervous system, and there are no side effects on the heart.

The presence of additional effects promotes the use of 3rd generation antihistamines for long-term treatment of most allergic manifestations.

Gismanal is prescribed as a therapeutic and prophylactic agent for hay fever, allergic skin reactions, including urticaria, and allergic rhinitis. The effect of the drug develops over 24 hours and reaches its maximum after 9-12 days. Its duration depends on previous therapy.

Advantages: the drug has virtually no sedative effect and does not enhance the effect of taking sleeping pills or alcohol. It also does not affect driving ability or mental performance.

Cons: Gismanal can cause increased appetite, dry mucous membranes, tachycardia, drowsiness, arrhythmia, prolongation of the QT interval, palpitations, collapse.

Mebhydrolin (diazolin)

Most experts classify diazolin as a first generation of antihistamines, while others, due to its minimally pronounced sedative effect, classify this drug as a second generation.

Be that as it may, diazolin is widely used not only in adults, but also in pediatric practice, being considered one of the most inexpensive and accessible medicines.

Desloratadine (Eden, Erius)

It is most often classified as a third generation antihistamine because it is an active metabolite of loratadine.

Cetirizine (Zodak, Cetrin, Parlazine)

Most researchers classify this medicine as a second generation of antihistamines, although some confidently classify it as a third because it is an active metabolite of hydroxyzine.

Zodak is well tolerated and rarely causes side effects. Available in the form of drops, tablets and syrup for oral administration. When taken once, the drug has a therapeutic effect throughout the day, so it can be taken only once a day.

Cetirizine relieves allergy symptoms, does not cause sedation, and prevents the development of smooth muscle spasm and swelling of surrounding tissues. Effective for hay fever, allergic conjunctivitis, urticaria, eczema, and relieves itching well.

Features of application. If the drug is prescribed in large doses, then you should refrain from driving vehicles, as well as work that requires quick reactions. When used together with alcohol, cetirizine can enhance its negative effects.

The duration of treatment with this drug can be from 1 to 6 weeks.

Fexofenadine (Telfast)

Most researchers also consider it to be a third generation of antihistamines, because it is an active metabolite of terfenadine. It can be used by those whose activities involve driving, as well as those suffering from heart disease.

1st generation antihistamines

Based on their chemical structure, these drugs are divided into the following groups:

Kestin should not be used together with Erythromycin and active Ketoconazole because there is a certain likelihood of prolongation of the QT interval.

Ebastine does not interact with the following drugs:

Diazepam;
medications that contain ethanol;
indirect anticoagulants;
Cimetidine;
Theophylline.

Currently, many different drugs are produced aimed at eliminating allergies or preventing them.

It is quite difficult to select the most effective one and this can only be done correctly under the guidance of a doctor after completing all the studies.

The antihistamine drug Kestin, produced in the form of film tablets, is incompatible:

With antifungal medications such as Fluconazole, Ketoconazole;
Antibiotics from the Macrolide group;
With a drug used in the treatment of asthma – Theophylline;
Indirect anticoagulants;
With the antiulcer drug Cimetidine;
With the drug Diazepam;
With medications manufactured using ethanol.

Lyophilized tablets are not prescribed simultaneously with Ketoconazole and Erythromycin, but can be used with those medications for which the use of film-coated tablets is contraindicated.

Lyophilized Kestin can also be consumed with moderate doses of alcohol.

The drug is freely available in pharmacies; it can be stored under normal conditions, when the room temperature does not exceed 25 degrees.

IMPORTANT TO KNOW: How allergies to antibiotics manifest.

Kestin is available in the following dosage forms:

Round, film-coated tablets are white with a marking on one side indicating the dosage of the active ingredient. Packaged in blisters of 5 or 10 units. Each cardboard box may contain 1 or 2 blisters.
Lyophilized tablets are round in shape, almost white in color. A cardboard box contains 1 blister containing 10 tablets.
Transparent, slightly yellowish syrup with a distinct anise odor. Packaged in dark glass bottles of 60 or 120 ml. The kit includes a measuring syringe.

Due to the high likelihood of developing a prolongation of the QT interval, the use of Kestin should not be combined with the use of erythromycin and/or ketoconazole.

The medication does not interact with cimetidine, theophylline, diazepam, indirect anticoagulants, ethyl alcohol and products containing ethanol.

Applications and dosages

Kestin should be consumed once a day at the appropriate time without any connection to food. The exact use depends on the type of tablet:

tablets in a package of 10 mg can be taken from the age of twelve, 1-2 pieces per day;
tablets weighing 20 mg are taken from the age of 15, half or a whole tablet, and from the age of 12 to 15 you can drink only half a tablet a day.

Kestin can be used for medicinal purposes regardless of food intake; the medicine does not need to be washed down with water.

When opening the package, you must be careful, as the tablets are quite fragile and easily break under pressure.

Treatment begins with a dose of 10 mg; if the desired effect is not observed, then the dosage is increased to 20 mg per day.

Children from 12 to 15 years of age are treated only with a dose of 10 mg per day. The same dosage should be observed in patients with severe liver dysfunction.

In other cases, the drug is taken according to the usual regimen. It should also be taken into account that the use of Kestin is contraindicated in some cases.

The medicine is not prescribed:

Pregnant women and women breastfeeding. Clinical trials of this group of patients have not been conducted, and therefore doctors cannot say with certainty how ebastine will affect the development of the fetus;
The drug in tablets is not used until the child reaches the age of twelve.

In rare cases, patients experience headache, slight dizziness, dyspepsia, abdominal pain, drowsiness, or, conversely, insomnia.

If these changes are very disturbing and do not go away within a few days, the doctor may reduce the daily dose.

There is no antidote for the drug, so in case of overdose, symptomatic therapy is used.

If you accidentally take several antihistamine tablets at once, you must rinse your stomach as quickly as possible.

The active ingredient of the drug is ebastine.

The pronounced antiallergic effect of Kestin begins 1 hour after administration and continues for 48 hours. After a 5-day course of treatment with the drug, antihistamine activity persists for 72 hours due to the action of active metabolites.

Therefore, with long-term use, you can use a convenient treatment regimen - 5 days on, 2 days off. Kestin is compatible with alcohol.

The high effectiveness and safety of Kestin has been confirmed by numerous foreign and Russian post-registration clinical studies.

The antiallergic drug Kestin Rapid Dissolution is indicated for allergic rhinitis of various etiologies (seasonal and/or year-round); urticaria of various etiologies, including chronic idiopathic.

The drug Kestin Rapid Dissolution is intended for resorption in the oral cavity, regardless of food intake.

Adults, children and adolescents over 15 years of age are prescribed 20 mg (1 lyophilized tablet) 1 time per day. The course of treatment is determined by the disappearance of symptoms of the disease.

In elderly patients, no dose adjustment is required.

In patients with impaired renal function, no dose adjustment is required.

For minor and moderate liver failure, the drug can be used in the usual dose. For severe liver dysfunction, the daily dose of ebastine should not exceed 10 mg.

To avoid damaging the tablets, do not remove the tablet from the blister by pressing. Open the package by carefully lifting the free edge of the protective film.

Remove the protective film.

Carefully squeeze out the drug without touching it.

Carefully remove the tablet and place it on the tongue, where it will quickly dissolve. There is no need to drink water or other liquid. Eating does not affect the effect of the drug.

From the nervous system: from 1% to 3.7% - headache, drowsiness; less than 1% - insomnia,

From the digestive system: from 1% to 3.7% - dryness of the oral mucosa; less than 1% - dyspepsia, nausea, abdominal pain.

From the respiratory system: less than 1% - sinusitis, rhinitis.

Other: less than 1% - asthenic syndrome; allergic reactions are possible.

Contraindications to the use of the drug Kestin Rapid Dissolution are: phenylketonuria; pregnancy; lactation period (breastfeeding); children under 15 years of age; hypersensitivity to the components of the drug.

Use with caution in patients with prolonged QT interval, hypokalemia, and renal and/or liver failure.

The use of Kestin Rapid Dissolution is contraindicated during pregnancy and lactation (breastfeeding).

Kestin lyophilized tablets 20 mg does not interact with theophylline, indirect anticoagulants, cimetidine, diazepam, ethanol and ethanol-containing drugs.

Kestin is prescribed to patients suffering from allergic pathologies of various etiologies. Before use, you should consult your doctor to determine any prohibitions on use.

for adults

The main conditions for which it is necessary to take Kestin are:

urticaria;
allergic rhinitis of a seasonal or year-round nature;
rhinitis caused by pollen, household allergens or medications;
allergic manifestations caused by particles of the epidermis;
pathologies associated with increased release of histamine.

for children

Children under 6 years of age are prohibited from taking any form of Kestin. For children over 6 years of age, the drug is prescribed for the same indications as for the adult group of patients.

for pregnant women and during lactation

During lactation and pregnancy, the use of Kestin is contraindicated due to the lack of information about the safety of use. For use during lactation, the patient must stop breastfeeding.

The method of use and dosage of the drug Kestin directly depend on its release form. Before starting use, you should consult an experienced physician.

Take 1–2 tablets (dosage 10 mg) and 0.5–1 tablet (dosage 20 mg) 1 time per day. Reception is not tied to the time of day and does not depend on meals.

Take 1 tablet 1 time per day. The product must be kept in the mouth until completely dissolved. You should not take the tablets with water.

Take 10–20 ml once a day.

10 mg – children over 12 years old, 1–2 tablets 1 time per day;
20 mg – for children from 12 to 15 years old, half a tablet and for children over 15 years old, from 0.5 to 1 tablet 1 time per day.

Children over 15 years old: 1 unit of product 1 time per day.

children from 6 to 12 years old, 5 ml per day;
from 12 to 15 years, 10 ml per day;
over 15 years old: 10 to 20 ml per day.

Pregnant patients and nursing women are prohibited from taking Kestin in any of the available forms of release.

If there is a special need for use during the lactation period, the woman should refuse to feed the baby with breast milk.

Indications for use

Kestin is prescribed to patients suffering from allergies of various forms. Before use, you should definitely consult a doctor to determine possible contraindications.

urticaria symptoms;
rhinitis caused by various factors;
allergies to pollen, household chemicals, medications;
allergies provoked by fragments of the epidermis;
diseases caused by increased concentrations of histamine in the blood.

The medicine has several absolute contraindications for use or prohibitions due to the specific form of release of the medicine.

Consider the list of absolute contraindications:

lactation period;
poor tolerance or increased sensitivity of the body to the effects of the active components of the substance.

You should not take Kestin in tablet form:

children under 12 years old;
when there is not enough lactose in the body;
with poor digestibility of lactose;
slight absorption of glucose-galactose.

You cannot drink lyophilized tablets:

children and adolescents under 15 years of age;
with phenylketonuria.

hypokalemia;
kidney and liver problems;
increased QT interval.

Contraindications for the drug include:

pregnancy and breastfeeding;
problems with the metabolic process;
The medication should be given with special care to children under six years of age.

The drug Kestin has a number of both absolute contraindications for use and prohibitions related directly to the dosage form of the drug.

Absolute contraindications:

lactation period;
intolerance or hypersensitivity of the patient to the action of the active component or auxiliary elements.

Film-coated tablets:

children under 12 years of age;
lactase deficiency;
lactose intolerance;
malabsorption of glucose-galactose.

Carefully:

hypokalemia;
renal and/or liver failure;
increased QT interval;
children up to 6 years of age (for Kestin in the form of syrup).

Pharmacological group	Antiallergic agent.
Main active ingredient	Ebastine
Release form	Syrup; Tablets: film-coated and lyophilized..
Main indications for use	Allergic rhinitis; Hives.
Mode of application	Inside, regardless of food intake. Lyophilized tablets must be dissolved until completely dissolved.
Dosage for treatment	Tablets: 10–20 mg 1 time per day; Syrup: 10–20 ml once a day.
Main contraindications	Hypersensitivity to the components of the drug, phenylketonuria.
Precautionary measures	Use caution if you have the following diseases: Kidney or liver failure; Hypokalemia; Increased QT interval.
Incompatible medications and foods	Antifungal drugs; Erythromycin, clarithromycin; Theophylline; Cimetidine; Diazepam.
Main side effects	Headaches, dry mouth.
Storage conditions and periods	Temperature no more than 30 0 C, dark place, 3 years