How to use furatsilin solution in the treatment of various diseases. How to prepare a solution. Furacilin release form

How are things going with salaries in RPL clubs? “Sokker.ru” compares investments in different leagues with the Russian championship.

The 18 World Cup has made football in Russia a little more fashionable than it was before, and new arenas are luring spectators. But so far, even one of the most popular clubs in the country does not have exactly 2,700 wealthy fans; it has 700 fewer fans to come to Krasnodar.

Objective reality. The league itself cannot be called poor, given the data from the official UEFA report and information about the personal contracts of individual stars, but the fans cannot feed it. Consequently, there is no system that allows the top 5 income from the sale of television rights to grow.

But there is another source of funding, inaccessible to many clubs on the planet - the state budget. Local officials are investing in football, various corporations (de facto or de jure state-owned) are also not stingy. If you look at the indicators, a lot becomes clear.

Only once since 2009 have European clubs seen revenues grow at a slower rate than wage costs. But even in this case, it was about 1.6%, a huge amount for the continent, but small in comparison with other years;

From 2008 to 2012, there was a tendency in football to increase spending on salaries in clubs - the peak share was 65.2% of the budget, but then there was a decline. Clubs now spend on average about 61.3% of all income on salaries, the lowest figure in the last ten years;

Footballers and staff of RPL clubs receive approximately 582 million euros per year. Not much compared to the top 5 - everyone now has more than a billion, but 582 million is a lot of money for dozens of European leagues. In terms of spending on salaries, Russia is in sixth place in Europe;

Turkey is next door - 557 million euros, but many elderly stars were invited, so such a large increase in expenses is easy to explain. Like Kazakhstan, but there is a jump to 85 million euros for the entire league. There are clubs in the RPL that spend more on salaries per year;

It is important to note the huge difference with the top 5 so that there are no illusions. Even if we recruit footballers who will be paid twice as much as they are now, the RPL will only be able to surpass France, where they spend approximately 1.1 billion euros per year;

The nuclear submarine has pulled away from everyone else - they are spending about 3 billion euros. Spain, at the expense of two clubs, remains second - 1.7 billion euros, followed by Germany and Italy - 1.4-1.5 billion each. On the other hand, in Serie A a couple of clubs have large salaries, and many have less than the leaders of the RPL;

If we talk about the percentage ratio of salary expenses and club income, then Russia is in the middle. There are abnormal figures - clubs from Ukraine and Greece spend 97-98% of their income on salaries for football players, and how they manage to survive is a mystery;

In Russia the average is 72%, and for the sixth most financial league in Europe this is a bit too much. Even the French, where there is PSG, spend 68% of income on salaries, and in the Premier League or Spain - 56-58% each. It is difficult to grow clubs if only 28% is spent on academies, development, infrastructure, recruits and other club needs;

Wage costs are rising throughout football Europe, so Russia has not stood aside. And in rubles, expenses have only increased, since salaries in leading clubs are written in euros or dollars - we know thanks to the threats of the Spartak stars to go to court if their salary is tied to the ruble;

The brother gets 36.4 million euros - approximately 2.6 billion rubles. This is the average for each of the 16 clubs. Although it is clear that there is no equality - clubs compete with a tenfold gap in budgets;

We can talk about equality in the distribution of funding only in two leagues - Norwegian and Swedish, although such a policy in football has not led to success. But in Scotland, Ukraine, Austria or Russia, the story is the same - there are very rich, there are moderately rich and poor;

When we talk about Russia, then for a small club to spend 76% of the budget on salaries is the norm. Moreover, in total it turns out to allocate only 14 million euros per brother. These are clubs from 7th to 16th places, often decent. The middle peasants in the RPL are officially a little poorer than in Turkey - there we are talking about 18 million euros for each;

On the other hand, clubs from 4th to 6th lines in terms of finances are Krasnodar, CSKA and Rubin (assuming that obligations are met and money comes in), on average, they can promise employees 57 million euros each. And it is clear that for some the number is higher, for others it is lower;

But with the giants from the top 3 richest - these are Zenit, Spartak and Lokomotiv, everything is extremely simple. They spend an average of 90 million euros a year on salaries. When they play with the Turks, they meet those who spend 78 million euros per team, with the Portuguese - 72, with the Dutch - 50;

The salary ratio between the leaders and outsiders of the RPL is large - 640%. Translated into human language, this means that if the poorest are people with incomes of 14,000 rubles a month, then the richest are like guys with a salary of 90 thousand rubles. The difference is not the biggest, but among successful leagues the situation is similar only in Portugal, where the gap is 1,750%, or almost 18 times;

Based on the results of the last financial year, for which UEFA conducted an audit and published a report, not a single Russian club is now in the top 20 most generous in terms of salaries. But earlier, Zenit was on the list, spending as much as 113 million euros on players and staff - almost the budget of Spartak. But every year in St. Petersburg they are trying to reduce this amount;

Compared to the leading clubs in Europe, salaries of 90-120 million euros do not seem huge - with such an indicator you will not get into the top 20. Tottenham spend 148 million euros a year, PSG - 272, and Real Madrid have crossed the 400 million euro mark. On the other hand, if Ajax spends around 50 million euros on salaries, and Spartak gets 90 million euros, then the question is, where are the Russian de Ligt and De Jong? The issue of matching investments and returns is relevant;

In Benfica or Porto, spending is noticeably lower than in Zenit or Lokomotiv. But Portuguese clubs beat Russian champions of different years. The Portuguese are not always in the finals, but where is at least the Russian João Felix? There is more than enough money for his upbringing, judging by the salaries;

By the way, many Russian football players with salaries average for the top 5 are richer than their Western colleagues. Compare the tax rates for the rich in many countries of the UEFA zone - in the region of 43-50%, and for the RPL - less than 30%;

Knowing the official data from the UEFA report, as well as having at hand approximate estimates of club budgets, you can estimate how much is spent on salaries in leading clubs. If we imagine that the entire fund is divided into 30 conditional players, then we can calculate the comparative average amount.

At Zenit it turns out 311 million rubles per year per person (4.32 million euros), at Spartak - 214 million rubles (2.97 million euros), and Lokomotiv - 183 million rubles, at Krasnodar - around 170 million rubles, in CSKA - around 150 million rubles per person. At the same time, the amounts are lower, because UEFA auditors took into account all expenses on club personnel.

But if we subtract a whole third and emphasize that the amount includes bonuses, we find that the average Zenit footballer earns approximately 2.8 million euros per year. Some have a more modest salary - two million and a few kopecks, others have more than three - like Dzyuba or Ivanovich. But in general, the official UEFA report coincides with Russian insiders.

The leading Russian clubs pay more than the middle peasants in Serie A. But the outsiders in the RPL are poor - by the standards of the top 5, for sure. However, here, after all, incomes in countries need to be compared. For a German, 30,000 rubles is not the most money; for a Russian, it’s a completely different matter. If clubs from 7th to 16th places have 20-30 million rubles per player per year, then this is enough money for the level of these players.

At the same time, the UEFA report clearly shows that Russia must dominate its top five - taking out everyone from Turkey, Holland, Portugal and Belgium, but so far it is not working out very well. Sometimes they lose to the Czechs in the Champions League, and they look for adventures with the Cypriots. But if a person has a salary of 1.5 million rubles a month, 5 million or as much as 20 million, then he has no reason not to try.

This money is more than enough to play high-quality professional football. Moreover, since in the RPL over 70% of all money ends up in the pockets of football players, this is a reason to think about reorganizing the entire system so that Dyukov is less likely to have to be distracted by the debts of Anzhi, for example. It is obvious that low taxes for the rich allow them to live well, and general expenditures from the budgets allow them to create good clubs.

Since there are no exorbitant earnings on match days - such as in Germany or England, if television rights in Russia are now sold cheaper than in the Romanian championship - Bucharest will be surprised when they find out, then we need to think about how to get off the needle of the state budget? How to earn money? Or, if there is no other way, at least spend it wisely. So that you understand, salaries in Krasnodar, CSKA or Rubin, not to mention the three richest, on average are no lower than in Ajax.

If this is not a reason to think about whether the limit helps - and because of it, salaries have largely increased, then what other reason do you need? No manager can explain the point of spending almost 600 million euros on salaries at 16 clubs. Especially if we are talking about a league where all teams receive twenty times less per year from television rights. A vicious circle - almost no one will survive without budget money, but as long as they feed from the treasury, there is zero motivation to learn how to earn money or win at home and in Europe.

Regardless of whether Zenit is first or fifth, the players’ salaries do not change. And ruble income has increased significantly in recent years. The eighth Lokomotiv or the first - it doesn’t matter. Whether Spartak is at the top or at its bottom, salaries do not change and remain huge by the standards of all European leagues, except for the five richest, with which no one is trying to compete. But do RPL clubs only lose to the giants?

Before answering the question “how to prepare a solution of furatsilin” from tablets, a few words must be said about the medicine itself. Furacilin is a drug that maintains an antimicrobial effect for a long time. However, you should remember that it should be stored in a place protected from light (ideally in a container made of dark glass). Otherwise, the solution prepared for use will turn brownish and lose its effectiveness.

Areas of application of the drug

Knowledge of how to prepare a solution of furatsilin will be useful for treating such minor damage to the skin as scratches, abrasions, cuts, and cracks. The most common use of furatsilin solution is as a mouth rinse (for sore throat, gingivitis, stomatitis) and eye wash (for conjunctivitis, blepharitis). In addition, the drug is effective for bedsores, 2nd and 3rd degree burns, osteomyelitis, and empyema of the paranasal sinuses.

How to prepare a solution of furatsilin

1. Buy the drug in tablets (0.02 g each) at the pharmacy. Ideally, of course, you should have furatsilin in your home/travel first aid kit.

2. Boil a glass of water. Wait about 8 minutes until the liquid is hot (but not boiling water).

3. Place one tablet of furatsilin on a clean sheet of paper and grind into powder using a masher, meat hammer or any other household utensil.

4. Pour the powder into a glass of hot water and, vigorously stirring with a teaspoon, wait until the medicine is completely dissolved. That's basically it. There is nothing complicated in such a matter as preparing a solution of furatsilin.

5. Wait for the medicinal solution to cool to approximately 40 degrees. Before rinsing your nose or eyes, be sure you won't burn yourself. It would also be a good idea to strain the medicine through a double layer of gauze to avoid getting undissolved particles of the tablet into the irritated oral cavity. Properly dissolved medicine will soften the mucous membrane, which will reduce pain.

6. If you have prepared an aqueous solution for future use, remember that it should be stored in the refrigerator for no more than ten days.

How to make a solution at home

This drug in the form of an alcohol solution has a detrimental effect on staphylococci, streptococci, Escherichia coli and dysentery coli, salmonella, Vibrio cholerae, clostridia and other microorganisms. In particular, furatsilin in this form is indicated for carrying out preventive and therapeutic measures for purulent-inflammatory processes and purulent wounds. The finished product, which contains 70% medical alcohol, is, in principle, sold in pharmacies. But today we’ll talk about how to make the necessary product yourself.

1. Buy 70 percent at the pharmacy (if the percentage is higher, dilute with water), as well as a package of furatsilin tablets (0.02 g each).

2. Grind the tablets to a powder as described above. In this case, for an amount of alcohol equal to 100 g, you will need three tablets. The solution must sit for several hours, after which it is considered ready for use.

Before preparing a solution of furatsilin, carefully read the instructions for the medicine, in particular, pay attention to the section called “Contraindications”. Thus, the product should not be used if there is bleeding, allergic dermatoses, hypersensitivity to the drug, pregnancy, etc. Otherwise, you may experience side effects such as dermatitis and allergic reactions.

Instructions for use

Furacilin instructions for use

Dosage form

Round, flat-cylindrical tablets from yellow to brownish-yellow in color with characteristic marbling, chamfered, with a score on one side.

Compound

Composition per tablet

Active substance:

Nitrofural (furacilin) ​​– 20 mg

Excipient:

Sodium chloride – 800 mg

Pharmacodynamics

Antimicrobial agent, nitrofuran derivative. Bacterial flavoproteins, restoring the 5-nitro group, form highly reactive amino derivatives that can cause conformational changes in proteins (including ribosomal ones) and other macromolecules, leading to the death of bacteria. Active against gram-positive and gram-negative bacteria (including Staphylococcus spp., Streptococcus spp., Escherichia coli, Clostridium perfringens). Resistance develops slowly and does not reach a high degree.

Pharmacokinetics

When applied externally and locally, absorption is negligible. Penetrates through histohematic barriers and is evenly distributed in liquids and tissues. The main route of metabolism is the reduction of the nitro group. Excreted by the kidneys and partially with bile.

Side effects

Allergic reactions, dermatitis, and skin itching are possible. If any of the side effects indicated in the instructions worsen, or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.

Selling Features

Available without a prescription

Special conditions

Influence on the ability to drive vehicles and mechanisms

The drug does not affect the ability to drive or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Indications

Externally: purulent wounds, bedsores, II-III degree burns, minor skin damage (including abrasions, scratches, cracks, cuts).

Locally: blepharitis, conjunctivitis, osteomyelitis, empyema of the paranasal sinuses and pleura; urinary tract infections - lavage of cavities, acute tonsillitis, stomatitis, gingivitis.

If necessary, please consult your doctor before using the medicine.

Contraindications

Hypersensitivity to nitrofural, nitrofuran derivatives and/or other components of the drug, bleeding, allergic dermatoses, severe renal dysfunction.

Use during pregnancy and breastfeeding

Before using the drug, if you are pregnant, or think you might be pregnant, or are planning a pregnancy, you should consult your doctor during breastfeeding.

Use during pregnancy and breastfeeding is possible if the expected benefit to the mother outweighs the potential risk to the fetus or child.

Drug interactions

Not studied

Prices for Furacilin in other cities

Mode of application

Dosage

Externally: in the form of an aqueous 0.02% solution - irrigate wounds, apply wet bandages.

Locally: blepharitis, conjunctivitis - instillation of an aqueous 0.02% solution into the conjunctival sac. Osteomyelitis after surgery - rinsing the cavity followed by applying a wet bandage. Empyema of the paranasal sinuses (including sinusitis) - washing the cavity, empyema of the pleura - after removing the pus, wash the pleural cavity and inject 20-100 ml of an aqueous 0.02% solution. To wash the urethra and bladder, use an aqueous 0.02% solution with an exposure of 20 minutes.

For tonsillitis, stomatitis, gingivitis - rinse the mouth and throat with 100 ml of an aqueous 0.02% solution 2-3 times a day. The duration of treatment is as indicated, depending on the nature and location of the affected area. If symptoms persist, it is recommended to consult a doctor.

Use the drug only according to the method of use and in the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.

LSR-001149/10-280814

INSTRUCTIONS for the use of the medicinal product for medical use FURACILIN

Name of the drug:
Trade name of the drug: Furacilin
International nonproprietary name: nitrofural
Chemical name: 5-nitrofurfural semicarbazone
Dosage form: solution for local and external use

Compound:
Active substance: nitrofural (furacilin) ​​- 0.2 g
Excipients: sodium chloride - 9.0 g, water for injection - up to 1 l

Description: clear yellow or greenish-yellow liquid

Pharmacotherapeutic group: antimicrobial agent - nitrofuran

ATX code: D08AF01

pharmachologic effect

Antimicrobial agent, nitrofuran derivative. Bacterial flavoproteins, reducing the 5-nitro group, form highly reactive amino derivatives that can cause conformational changes in proteins (including ribosomal ones) and other macromolecules, leading to the death of bacteria.
Active against gram-positive and gram-negative bacteria (Staphylococcus spp., Streptococcus spp., Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Escherichia coli, Clostridium perfringens, Salmonella spp., etc.).
Resistance develops slowly and does not reach a high degree. Increases the activity of the reticuloendothelial system, enhances phagocytosis.
Pharmacokinetics
Absorption is fast and complete. The time required to achieve maximum concentration is 6 hours. It easily penetrates histohematic barriers and is evenly distributed in liquids and tissues. The main route of metabolism is the reduction of the nitro group. It is excreted by the kidneys and partially through the intestines.

Indications for use

Externally: purulent wounds, bedsores, II-III degree burns, minor skin damage (including abrasions, scratches, cracks, cuts).
Local: blepharitis, conjunctivitis; osteomyelitis, empyema of the paranasal sinuses and pleura - washing the cavities; acute tonsillitis, stomatitis, gingivitis.

Contraindications

Hypersensitivity to nitrofural, nitrofuran derivatives and/or other components of the drug; bleeding, allergic dermatoses.

Use during pregnancy and breastfeeding

There is no data on the possible negative impact of the drug on the health of a pregnant woman or child. However, during pregnancy and breastfeeding it is used only after consultation with a doctor, if the intended benefit to the mother outweighs the potential risk to the fetus and child.

Directions for use and doses

Irrigate purulent wounds, bedsores, II-III degree burns, minor skin injuries (including abrasions, scratches, cracks, cuts) and apply wet bandages.
Intracavitary: for sinusitis, wash the maxillary cavity; for osteomyelitis after surgery - rinsing the cavity followed by applying a wet bandage; pleural empyema - after removing the pus, the pleural cavity is washed and 20-100 ml of an aqueous solution is administered.
Blepharitis, conjunctivitis - installation of an aqueous solution into the conjunctival sac.
Acute tonsillitis, stomatitis, gingivitis - rinse the mouth and throat.
The duration of treatment according to indications depends on the nature and location of the affected area.

Side effect

Allergic reactions, dermatitis. If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

In case of overdose, side effects may increase. Treatment: symptomatic.

Interaction with other drugs

Incompatible with epinephrine (adrenaline), tetracaine, procaine (novocaine), resorcinol (resorcinol) and other reducing agents, since it decomposes to form pink or brownish-colored products. Incompatible with potassium permanganate, hydrogen peroxide and other oxidizing agents due to oxidation of the drug.

Impact on the ability to drive vehicles and machinery

The use of the drug does not affect the ability to drive vehicles or machinery.

Release form
Solution for local and external use 0.02%.
200, 400 ml in glass bottles for blood, transfusion and infusion drugs or glass bottles for pharmaceutical and infusion drugs, sealed with rubber stoppers and crimped with aluminum caps. The bottle, along with instructions for use, is placed in a cardboard pack.
For hospitals: 28 bottles of 200 ml or 15 bottles of 400 ml, together with an equal number of instructions for use, are placed in corrugated cardboard boxes with gaskets, with partitions or grids (“nests”) without prior packing.

Solution 0.02% yellow, transparent.

Excipients: sodium chloride, water d / i.

200 ml - blood bottles (1) - cardboard packs.
200 ml - blood bottles (20) - cardboard boxes.
200 ml - blood bottles (40) - cardboard boxes.

Solution 0.02% yellow, transparent.

Excipients: sodium chloride, water d / i.

400 ml - blood bottles (1) - cardboard packs.
400 ml - blood bottles (12) - cardboard boxes.
400 ml - blood bottles (24) - cardboard boxes.

Description of the drug FURACILIN created in 2012 on the basis of instructions posted on the official website of the Ministry of Health of the Republic of Belarus.

Date of update: 08/09/2013

pharmachologic effect

Furacilin is an antimicrobial agent from the group of nitrofuran derivatives. When entering a microbial cell, nitrofurans, due to the presence of a nitro group (N 2 O) attached to the furan core, as well as an unsaturated nitrogen-containing bond (C=N) in the side chain, can act as competitive acceptors of hydrogen ions in the metabolic chain of electron transfer from flavins enzymes for cytochrome. They inhibit energy production in the cell and thereby suppress the growth and reproduction of microbes. It has also been shown that nitrofurans suppress the formation of citric acid from oxaloacetic acid, i.e. inhibit the normal course of reactions in the Krebs cycle.

Pharmacokinetics

When applied locally and externally, absorption is negligible. Once ingested, absorption is rapid and complete. Penetrates through histohematic barriers and is evenly distributed in liquids and tissues. The time required to reach Cmax is 6 hours. The main metabolic pathway is the reduction of the nitro group. It is excreted by the kidneys and partially through the intestines.

Dosage regimen

Locally, outdoors. Irrigate wounds and apply wet bandages. Intracavitary:

• with sinusitis- wash the maxillary cavity;
• with osteomyelitis- rinsing the cavity followed by applying a wet bandage;
• pleural empyema- after removing the pus, the pleural cavity is washed and 20-100 ml of an aqueous solution is administered. Wash with an aqueous solution of furatsilin purulent wounds, bedsores and ulcers, II and III degree burns of the skin and mucous membranes. The drug is used to irrigate the granulating surface in preparation for skin grafts.

Blepharitis, conjunctivitis- installation of an aqueous solution into the conjunctival sac, 2-3 drops 3-4 times a day.

For sore throat, stomatitis and gingivitis- rinse the mouth and throat 100 ml 2-3 times a day.

For chronic purulent otitis 8-10 drops of furatsilin solution are applied to a cotton swab or turunda and injected into the external auditory canal 2 times a day. Before use, the solution should be warmed to room temperature.

For anaerobic infection In addition to conventional surgery, the wound is treated with a solution of furatsilin.

Furacilin solution is used in the treatment boils of the external auditory canal and epiema of the paranasal sinuses. Damaged areas are washed 2-4-6 times a day (depending on the severity of the damage).

Due to the fact that there is insufficient safety data, the drug should not be used by children and adolescents under the age of 18 years.

Side effects

Some patients may develop allergic dermatoses when using furatsilin solution. If such phenomena occur in patients, a break in treatment should be taken or the drug should be discontinued.