Acc long - official instructions for use. ACC Long: instructions for use ACC Long instructions for use 600 mg

For sticky sputum, pediatricians often prescribe mucolytics. Among such drugs, ACC Long is very popular, but is such a medicine allowed in childhood?

Release form

The drug is available in the form of effervescent tablets. They are white in color and round in shape. By dissolving such a tablet in water, you will get a clear, colorless liquid that smells like blackberries. The tablets are packaged in tubes made of polypropylene. One tube contains 10 or 20 effervescent tablets.

Children like the chewy form of the tablets

Compound

The main component in ACC Long is acetylcysteine. Each tablet contains 600 mg of this substance. Additionally, the tablets contain lactose, sodium carbonate, citrate and bicarbonate, citric acid, sodium saccharinate and cyclamate, mannitol, ascorbic acid and blackberry flavor.

Operating principle

The medicine is a mucolytic agent and, after entering the body, affects mucopolysaccharides in sputum, reducing the viscosity of the mucus secreted by the bronchi. The drug is active even with purulent inflammation.

Can it be given to children?

The instructions for use contain information that ACC Long is not given to children under 14 years of age, since the dosage of acetylcysteine in it is too high. For younger children, other forms of release with a reduced content of the active substance are suitable:

Syrup.
Soluble granules.
Effervescent tablets.

At a dose of 100 mg, the drug is approved from the age of 2, and a dosage of 200 mg is prescribed from the age of 6.

A variety of release forms will help you choose the best option for your child.

Indications

Contraindications

ACC Long should not be prescribed for:

Intolerance to any component of the drug.
Exacerbation of peptic ulcer disease.
Hemoptysis.
Bleeding from the lungs.
Lactase deficiency.

The drug is given with caution for bronchial asthma, diabetes mellitus, kidney or liver dysfunction, as well as high blood pressure and pathologies of the adrenal glands.

Side effects

The child's body almost does not react to ACC long with side symptoms if the drug is given after 14 years of age and in the correct dose.

Rare negative reactions to this remedy are headaches, stomatitis, bronchospasm, itching, tinnitus, urticaria, and bleeding. Some patients may experience decreased blood pressure, diarrhea, nausea, rapid heartbeat, and heartburn.

Detailed video instructions for the drug ACC:

Instructions for use and dosage

A child over 14 years old is given 1 tablet of the drug per day. For the treatment of ARVI, the medicine is used for 5 to 7 days, and for more serious pathologies, the duration of therapy should be determined by the doctor on an individual basis.

Place the tablet in a glass of clean water, wait until it dissolves, and drink immediately. This should be done after one of the meals. The prepared solution should not be stored for longer than 2 hours. ACC Long should only be mixed with water in a glass container, since upon contact with metal or rubber, such a medicine will form sulfides (there will be an unpleasant odor).

Overdose

If you exceed the dose of ACC Long, it will lead to nausea, abdominal pain, diarrhea, heartburn or vomiting. In such a situation, symptomatic therapy is prescribed.

Interaction with other drugs

If antitussive medications are prescribed along with ACC long, this can lead to stagnation of mucus in the bronchial tree.
Nitroglycerin taken together with ACC long has a stronger vasodilator effect.
When taking acetylcysteine, the absorption of penicillin antibiotics, as well as tetracyclines and cephalosporins, decreases. If these medications are prescribed together, separate their doses so that there is at least a 2-hour break between them.
ACC Long and proteolytic enzymes should not be taken together.

Terms of sale

ACC Long is an over-the-counter drug, so it can be freely purchased at the pharmacy. The average price of a tube with 10 tablets is 300-350 rubles.

Storage conditions and shelf life

To store ACC Long, you need a dry place hidden from sunlight, where the temperature will not exceed +30°C. From the date of release, the tablets can be used for 3 years.

Instructions
on medical use of the drug

ACC ®

International nonproprietary name: acetylcysteine.

Chemical name: N-acetyl - L-cysteine.

Dosage form.
Granules for the preparation of a solution for oral administration.

Composition of the medicinal product.
1 sachet of granules weighing 3 g for the preparation of an oral solution contains:
active ingredients: 600 mg acetylcysteine;
excipients: ascorbic acid, saccharin, sucrose, lemon and honey flavors.

Description.
White homogeneous granules no larger than 1.5 mm in size without agglomerates and mechanical impurities, with the smell of lemon and honey

Pharmacological properties.
Pharmacotherapeutic group.
Mucolytic agent.
ATX code: R05CB01.

Pharmacodynamics.
The presence of sulfhydryl groups in the structure of acetylcysteine promotes the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum.
With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Indications for use.
Respiratory diseases accompanied by the formation of viscous, difficult to separate sputum: acute and chronic bronchitis, obstructive bronchitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis.
Acute and chronic sinusitis, otitis media.

Contraindications.
Hypersensitivity to acetylcysteine or other components of the drug. Peptic ulcer of the stomach and duodenum in the acute stage; hemoptysis, pulmonary hemorrhage; pregnancy, breastfeeding, children under 14 years of age.
With caution - varicose veins of the esophagus, bronchial asthma, diseases of the adrenal glands, liver and/or kidney failure.
Acetylcysteine should be used with caution in patients prone to pulmonary bleeding and hemoptysis.

Pregnancy and lactation period.
For safety reasons, due to insufficient data, the use of the drug during pregnancy and lactation is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or infant.

Method of administration and dose.
In the absence of other prescriptions, it is recommended to adhere to the following dosages:
Adults and adolescents over 14 years of age are recommended to take 1 sachet of ACC ® (600 mg acetylcysteine per day) once a day.

Cautions.
Due to the high content of the active substance (600 mg of acetylcysteine per sachet), the drug should not be taken by children under 14 years of age. In this case, it is recommended to use the drug ACC ® in other dosage forms with a lower acetylcysteine content.
The drug should be taken after meals.
The powder is dissolved with stirring in 1 glass of hot water and drunk, if possible, hot. If necessary, it is possible to leave the prepared solution for 3 hours.
Additional fluid intake enhances the mucolytic effect of the drug.
For short-term colds, the duration of use is 5-7 days.
For chronic bronchitis and cystic fibrosis, the drug should be taken for a longer period of time to achieve a preventive effect against infections.
Instructions for patients with diabetes: 1 sachet weighing 3 g corresponds to 0.17 bread. units

Side effects.
In rare cases, headaches, inflammation of the oral mucosa (stomatitis) and tinnitus appear. Extremely rare - diarrhea, vomiting, heartburn and nausea, drop in blood pressure, increase in heart rate (tachycardia). In isolated cases, allergic reactions such as bronchospasm (mainly in patients with bronchial hyperreactivity), skin rash, itching and urticaria are observed. In addition, there are isolated reports of bleeding due to hypersensitivity reactions.
If side effects develop, you should stop taking the drug and consult a doctor.

Overdose.
In case of an erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed. To date, no severe or life-threatening side effects have been observed.

Interaction with other means.
With the simultaneous use of acetylcysteine and antitussives, mucus stagnation may occur due to suppression of the cough reflex. Therefore, such combinations should be selected with caution.
Pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.
Reduces the absorption of penicillins, cephalosporins, tetracycline (they should be taken no earlier than 2 hours after ingestion of acetylcysteine).
The simultaneous use of acetylcysteine and nitroglycerin can lead to an increase in the vasodilatory effect of the latter.
Upon contact with metals and rubber, sulfides with a characteristic odor are formed.

Special instructions.
For patients with bronchial asthma and obstructive bronchitis, acetylcysteine should be prescribed with caution under systematic monitoring of bronchial patency.
When treating patients with diabetes, it is necessary to take into account the presence of sucrose in the composition of the drug: 1 sachet corresponds to 0.17 units of bread.
When working with the drug, you must use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

Release forms.
Cardboard packages of 6, 10 or 20 sachets containing 600 mg of acetylcysteine and instructions for use.

Storage conditions.
Keep out of the reach of children at a temperature not exceeding 25°C.

Best before date.
3 years.
Do not use after the expiration date indicated on the package!

Release from pharmacies.
Over the counter.

Manufacturer.
Hexal AG, manufactured by Salutas Pharma GmbH, 83607 Holzkirchen, Industrialstrasse 25, Germany.
Representative office in Moscow: 121170 Moscow, st. Kulneva, 3.

Quite often, doctors prescribe the drug “ACC” (“ACC”) for cough to their patients. Instructions for the use of this remedy, as well as its contraindications, indications and side effects will be presented in this article. In addition, we will tell you about the form in which the mentioned medicine is produced, what patients say about it, how much it costs, and so on.

Packaging of the drug, its release form, composition

Do you know in what form the medicine “ACC” (“ACC”) for cough is produced? The instructions for use inform us that this drug is produced in two different forms. Let's look at them in more detail:

Medicine "ACC" is a powder (granulated) intended for the preparation of a solution. This medicine should only be taken orally. One 3-gram packet of powder can contain 200, 100 or 600 mg of acetylcysteine. There are 10, 6 or 20 sachets in a cardboard pack.
The drug "ASS" - effervescent tablets. Aluminum or cardboard tubes can contain 20, 10, 100 or 50 pieces. One tablet contains 600, 200 or 100 mg of acetylcysteine. As for the auxiliary components, these include citric anhydride, sodium bicarbonate, ascorbic acid, mannitol, lactose anhydride, sodium citrate, blackberry flavor and saccharin.

Pharmacological action of the drug

What is “ACC” (“ACC”) cough medicine? The instructions for use state that this is a mucolytic drug. Due to the fact that the structure of the acetylcysteine molecule contains sulfhydryl groups, this causes the rupture of disulfide bonds of mucopolysaccharides (acidic) of sputum. As a result of this effect, the patient's mucus viscosity noticeably decreases.

The drug in question has a mucolytic effect and also facilitates the discharge of sputum due to a direct effect on its rheological properties. This remedy retains its activity even in the presence of purulent mucus.

The ACC medicine, the instructions for which are presented below, is very often used for preventive purposes. In this case, there is a decrease in the severity and frequency of exacerbations in patients with cystic fibrosis and chronic bronchitis.

Pharmacokinetics of the drug

What pharmacokinetic properties does the drug "ACC" have? The instructions do not contain such information. This is due to the fact that pharmacokinetic studies of this medication have not been conducted.

Drug "ACC": indications

The drug in question is prescribed for the following deviations:

acute and chronic sinusitis;
diseases of the respiratory system, which are accompanied by the formation of difficult to separate and viscous sputum (for example, with bronchiectasis, acute and chronic bronchitis, cystic fibrosis, obstructive bronchitis, pneumonia, bronchial asthma and bronchiolitis);
otitis media.

Contraindications

In the presence of what abnormalities should the medicine "ACC" (powder and effervescent tablets) not be prescribed? The following conditions are contraindications to the use of this drug:

It should also be noted that this medication is prescribed with extreme caution to patients with varicose veins of the esophagus, diseases of the adrenal glands, renal and/or liver failure.

Mode of application

How should you take ACC for cough? The instructions for use contain the following instructions in this regard. For adolescents and adults, it is prescribed 200 mg three times a day. Children from 6 to 14 years old should take the medicine 100 mg three times a day. For children from 2 to 5 years old, the medication is prescribed 1 tablet (100 mg) twice a day. For a disorder such as cystic fibrosis, a child over 6 years of age is given 2 tablets of the drug (100 mg each) three times a day. As for children from 2 to 6 years old, they should take the medication 100 mg four times a day.

For patients with cystic fibrosis weighing more than 30 kg, the dosage can be increased to 800 mg per day.

For colds of a short-term nature, the duration of therapy with the presented medication is 5-7 days. For cystic fibrosis and chronic bronchitis, the drug must be used for a longer time (to prevent infections).

How should I take ACC 200? The instructions state that this drug should be used only after meals (to avoid negative effects on the gastric mucosa). It should be especially noted that additional fluid intake enhances the mucolytic effect of the drug.

Before use, effervescent tablets must be dissolved in half a glass of plain water. The prepared solution should be used immediately. In exceptional cases, it can be left for 2 hours.

Overdose

In case of intentional or mistaken overdose of the drug, the patient experiences symptoms such as vomiting, stomach pain, diarrhea, heartburn and nausea. To date, no severe or life-threatening side effects have been observed.

Drug interactions

What happens if you take any medications and ACC at the same time? Reviews from experts say that combined treatment can cause a number of unwanted reactions. Let's look at them a little further.

With the simultaneous use of acetylcysteine and other antitussive drugs, a stagnation of mucus that is dangerous to health may occur (due to suppression of the cough reflex).

During the simultaneous use of nitroglycerin and acetylcysteine, there is a possibility of enhancing the vasodilating effect of the former.

There is a synergism of acetylcysteine with the simultaneous use of bronchodilators.

Acetylcysteine can reduce the absorption of penicillins, cephalosporins and tetracycline. In this regard, they must be taken orally 2 hours after taking the first one.

Acetylcysteine is not compatible with antibiotics such as Penicillin, Erythromycin, Cephalosporin, Tetracycline and Amphotericin, as well as proteolytic enzymes.

When acetylcysteine comes into contact with rubber and metal, sulfides are formed, which have a characteristic odor.

special instructions

For obstructive bronchitis and bronchial asthma, the drug in question should be prescribed with extreme caution. This requires systematic monitoring of bronchial patency.

If, after taking the medication, the patient develops side effects, then it is necessary to stop taking the medication and immediately consult a doctor.

When treating patients with diabetes, it should be taken into account that 1 effervescent tablet corresponds to 0.006 XE.

To date, there is no information about the negative impact of the drug (in recommended dosages) on the ability to drive a car or perform other activities that require special concentration.

Shelf life and storage methods

The drug in question must be stored only in a dry place inaccessible to small children. In this case, the air temperature should not be higher than 25 °C. The shelf life of the drug is three years. After this time, the use of the medication is prohibited.

After taking the effervescent tablet, the plastic or aluminum tube must be tightly closed.

Price and analogues of the drug

The price of the ACC tablet may vary depending on the pharmacy chain, as well as on the markup on the product. However, on average, such a medicine costs about 75-150 Russian rubles. The price of granular powder is similar to effervescent tablets.

What can replace the product in question? Pharmacy chains have a huge number of analogues of the drug, as well as drugs with a similar effect (expectorant, mucolytic). Among the most popular, I would like to highlight the following medications: “Acestine”, “Acetylcysteine”, “Vicks Active ExpectoMed”, “Mukobene”, “Mukomist”, “Mukonex”, “N-AC-Ratiopharm”, “Fluimucil”, “Exomyuk 200” , "Atsestad", "Lazolvan", "Ambrobene", "Ambroxol", "Mukosol", "Bronkatar", "Solvin", "Bromhexin", "Gedelix", "Mukaltin", "Prospan", "Stoptussin", " Askoril", "Linkas" and others.

Patient reviews of the medication

Now you know what analogues of the drug “ACC” are available and what its price is. Tablets and powder for preparing the solution cope quite effectively with the task. This is the opinion that most patients hold. The drug quickly treats acute and chronic sinusitis, as well as other respiratory diseases. Thanks to it, viscous and difficult to separate sputum easily moves away from the bronchi, significantly improving the condition of the sick person.

It should also be noted that the product in question is not only highly effective, but also relatively inexpensive. This fact is very pleasing to patients who cannot afford to purchase expensive medications.

Effervescent tablets "Acc Long" - instructions

Cough and runny nose are probably the most common ailments. You can catch them not only in the cold season, but also in the summer, by swimming in cold water or sitting in a draft. Therefore, drugs that alleviate the condition of these diseases are very popular. One of them is “Acc Long 600” effervescent tablets. They are convenient because they do not need to be swallowed, and they also act faster.

Tablets "Acc Long 600" - instructions

Dosage form – effervescent tablets for dissolution, 600 milligrams, in a tube.

International name: Acetylcysteine.

Additional substances - saccharin, vitamin C (ascorbic acid), lactose, sodium carbonate, mannitol, sodium citrate, citric acid, sodium bicarbonate, sodium cyclamate, flavoring.

Group – mucolytics.

Pharmacological properties

It is an expectorant, mucolytic agent with detoxification and pneumoprotective properties. It is used for diseases of the respiratory system accompanied by the formation of mucus. Reduces its viscosity, thins sputum. Provides an anti-inflammatory effect, reducing the risk of acute and chronic processes in the respiratory tract and lung tissue. The effect of the drug lasts for 2-4 hours.

"Acc Long" tablets - instructions: indications

Diseases accompanied by difficult sputum separation: pneumonia, bronchitis, bronchiectasis, and other ailments that require reducing the viscosity of mucus, improving its expectoration and discharge. The drug is also used for bronchial asthma, cystic fibrosis, rhinitis, otitis, and sinusitis. Used to reduce complications after respiratory surgery as a prophylaxis and for paracetamol poisoning as an antidote.

"Acc Long" tablets - instructions: dosage

Taken orally, the dose depends on the severity of the disease. You can take this drug as early as two weeks of life.

In the presence of acute diseases: a single dose for children under two years old - 50 milligrams, over six years old - 100 milligrams, over 14 years old - 200 milligrams two or three times a day.

Teens and adults take 400 to 600 milligrams in one or two doses. In this case, the recommended course of treatment is from five to seven days.

If long-term use is expected, for example, for the treatment of chronic diseases, then children from six to 14 years old drink up to 100 milligrams three times a day, and adults - from 400 to 600 milligrams per day.

For cystic fibrosis: a single dose for children from ten days to two years – 50 milligrams, from two to six years – 100 milligrams, from six years – 200 milligrams three times a day. If a child weighs more than 30 kilograms, he can increase the dose to 800 milligrams during the day.

The drug is taken after meals. The tablet must be dissolved in a full glass of water and drunk as quickly as possible. In exceptional cases, it can be left for a maximum of two hours. Additional consumption of water and any other liquid enhances the effect of the product.

"Acc Long" tablets - instructions: contraindications

Sensitivity to any components of the drug;

Exacerbation of gastric or duodenal ulcers; caution should be used in chronic forms;

Pulmonary hemorrhage, hemoptysis.

Use of the drug during pregnancy and lactation is possible only if the possible benefit to the mother is higher than the potential risk to the fetus or child.

The drug does not in any way affect the reaction rate when driving equipment or a car.

"Acc Long" tablets - instructions: overdose

In rare cases, vomiting, nausea, and diarrhea are possible.

Interaction with other drugs

When taking activated carbon at the same time, the effectiveness of the drug is reduced.

When taken simultaneously with nitroglycerin, the vasodilator effect may be enhanced.

The drug "ACC" (powder) - instructions for use

Colds, coughs, runny noses, and bronchitis cause a lot of inconvenience. In this state, it is difficult to fully work and do normal activities. Often, medications that suppress the manifestations of these diseases are used to reduce symptoms. But the main thing in the treatment of problems of the upper respiratory tract is stimulation of mucus discharge. By clearing our throat, we clear our lungs, and by blowing our nose, we clear our nose. The more often this happens, the fewer harmful substances accumulate in the body, and the risk of complications decreases. One of the drugs that helps in this case is ACC powder. It stimulates mucus production, which helps relieve symptoms and avoid complications.

The drug "ACC 100" (powder), the instructions confirm this, has the Latin name "ACC".

Dosage form - powder used to make a solution, taken orally. Each pack contains two pieces of 100 or 200 milligrams (respectively, the drugs “ACC 100” and “ACC 200”).

Pharmaceutical group – expectorant, mucolytic agent. Stimulants of respiratory tract functions and secretolytics.

Composition – 100/200 milligrams of acetylcysteine. Additional substances - saccharin, vitamin C (ascorbic acid), flavoring, sucrose. One sachet of the drug contains 0.24 bread units.

A drug "ACC" (powder). ANDinstructions for use: indications

The drug is used for various diseases affecting the respiratory tract, which results in the formation of viscous sputum. This:

pneumonia;
acute or chronic bronchitis;
tracheitis;
bronchial asthma;
cystic fibrosis;
bronchiectasis;
bronchiolitis;
acute or chronic sinusitis;
inflammation of the middle ear (otitis media);
laryngitis;
any cough with sputum that is difficult to clear.

A drug "ACC" (powder). ANDinstructions for use: dosage

Adolescents over 14 years of age and adults take 400-600 milligrams per day, children from six to 14 years inclusive - from 300 to 400 milligrams, from two to five years - 200-300 milligrams, from ten days to two years - 100 -150 milligrams. The daily dose should be divided into two or three doses.

For cystic fibrosis, doses are prescribed: children under two years old - 100-150 milligrams per day, two to five years old - 400 milligrams, children over six years old - 600 milligrams. The daily dose is divided into two or three doses. If the child’s weight exceeds 30 kilograms, it is possible to increase the dose to 800 milligrams per day.

The drug is taken immediately after meals. The powder from the bag dissolves in a glass of water or juice. In case of acute diseases that are not accompanied by complications, the drug can be continued for five to seven days. For chronic ailments, the course of treatment lasts up to six months.

A drug "ACC" (powder). ANDinstructions for use: contraindications

Medicine is not prescribed ,

sensitivity of the body to any components of the powder;
fructose intolerance;
peptic ulcer;
hemoptysis;
pulmonary hemorrhage;
renal failure;
hepatitis;
liver failure.

A drug "ACC" (powder). ANDinstructions for use: side effects

This product is well tolerated. The following symptoms may occur in rare cases:

in the digestive system - nausea, stomatitis, vomiting, heartburn, diarrhea;
CNS – tinnitus or headache;
in the cardiovascular system - increased heart rate, arterial hypotension;
allergic manifestations - rash, itchy skin, bronchospasm.

A drug "ACC" (powder). ANDinstructions for use: special instructions

During lactation or pregnancy, the drug is used only if necessary and as prescribed by a doctor.

For children under one year of age, the drug is prescribed only for health reasons. Treatment must be carried out under the supervision of a specialist.

For children under two years of age, the drug is prescribed only under the supervision of a doctor.

There was no effect of the drug on the speed of reactions when driving a vehicle or any other work with machinery.

pharmacodynamics. Acetylcysteine (ACC) is a mucolytic expectorant used to thin out mucus in diseases of the respiratory system accompanied by the formation of thick mucus. Acetylcysteine is a derivative of the amino acid cysteine. The mucolytic effect of the drug is of a chemical nature. Due to the presence of a free sulfhydryl group, acetylcysteine breaks the disulfide bonds of acidic mucopolysaccharides, which leads to depolymerization of sputum mucoproteins and a decrease in the viscosity of mucus and promotes expectoration and discharge of bronchial secretions. The drug remains active in the presence of purulent sputum.

Acetylcysteine also has antioxidant pneumoprotective properties due to the binding of chemical radicals by its sulfhydryl groups and, thus, their neutralization. In addition, the drug helps to increase the synthesis of glutathione, an important factor in intracellular protection not only from oxidized toxins of exogenous and endogenous origin, but also from a number of cytotoxic substances. This feature of acetylcysteine makes it possible to effectively use the latter in case of an overdose of paracetamol.

Pharmacokinetics. After oral administration, acetylcysteine is quickly and completely absorbed and metabolized in the liver to form cysteine, a pharmacologically active metabolite, as well as diacetylcysteine, cystine, and subsequently mixed disulfides. Bioavailability is very low - about 10%. Cmax in blood plasma is reached 1-3 hours after administration. Binding to blood plasma proteins is about 50%. Acetylcysteine is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine).

T ½ is determined mainly by rapid biotransformation in the liver and is about 1 hour. In case of decreased liver function, T ½ increases to 8 hours.

treatment of acute and chronic diseases of the bronchopulmonary system, which require reducing the viscosity of sputum, improving its discharge and expectoration.

adults and children over 14 years of age are prescribed 400-600 mg of acetylcysteine per day, divided into 1-3 doses.

Children aged 6-14 years: 400-600 mg/day, divided into 2-3 doses.

Children aged 2 to 6 years: 200-400 mg/day, divided into 2 doses.

It is recommended to take the drug after meals. Dissolve the contents of the sachet with stirring in ½ glass of hot water and drink, if possible, hotter. Additional fluid intake enhances the mucolytic effect of the drug.

The duration of treatment for chronic diseases is determined by the doctor depending on the nature and course of the disease. For acute uncomplicated diseases, acetylcysteine should be used for 5-7 days.

hypersensitivity to acetylcysteine or other components of the drug.

Peptic ulcer of the stomach and duodenum in the acute stage, hemoptysis, pulmonary hemorrhage.

from the cardiovascular system: tachycardia, arterial hypotension.

From the nervous system: headache.

From the skin: allergic reactions (itching, urticaria, exanthema, eczema, rash, angioedema).

On the part of the hearing organ: tinnitus.

From the respiratory system: shortness of breath, bronchospasm (mainly in patients with hyperreactivity of the bronchial system, which is associated with asthma), rhinorrhea.

From the digestive tract: heartburn, dyspepsia, stomatitis, abdominal pain, nausea, vomiting, diarrhea, bad breath.

General violations: fever.

Isolated severe skin reactions (Stevens-Johnson-Lyell syndrome) have been reported. When using acetylcysteine, bleeding was very rarely reported, which was most often associated with the development of hypersensitivity reactions. There have been cases of decreased platelet aggregation, but there is no clinical confirmation of this. Very rarely, angioedema, facial swelling, cases of anemia, hemorrhage, anaphylactic reactions or even shock have been reported.

It is recommended to use with caution in patients with a history of gastric and duodenal ulcers, especially in the case of concomitant use of other drugs that irritate the gastric mucosa.

There are isolated reports of severe skin reactions (Stevens-Johnson and Lyell syndrome) when taking acetylcysteine, so if changes occur in the skin or mucous membranes, you should immediately stop using the drug and consult your doctor regarding further use.

Acetylcysteine should be prescribed with caution to patients with asthma due to the possible development of bronchospasm. When pouring the contents of the sachet into a bowl during preparation of the solution, the powder may enter the air and irritate the nasal mucosa, which may result in reflex bronchospasm.

In patients with liver or kidney disease, acetylcysteine should be prescribed with caution to avoid the accumulation of nitrogen-containing substances in the body.

The use of acetylcysteine causes dilution of bronchial secretions. If the patient is unable to cough up sputum effectively, postural drainage and bronchoaspiration are necessary.

Acetylcysteine affects histamine metabolism, so long-term therapy should not be prescribed to patients with histamine intolerance, as this may lead to symptoms of intolerance (headache, vasomotor rhinitis, itching).

The drug contains sucrose, so it should not be prescribed to patients with rare hereditary forms of fructose intolerance, sucrose-isomaltase deficiency or glucose-galactose malabsorption syndrome.

Information for patients with diabetes. 1 sachet of powder (200 mg acetylcysteine) contains 2.5 g of sucrose (0.21 XE).

1 sachet of powder (600 mg acetylcysteine) contains 2 g of sucrose (0.17 XE).

Use during pregnancy or breastfeeding. During pregnancy and lactation, the use of acetylcysteine is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or child.

The ability to influence reaction speed when driving vehicles or working with other mechanisms. Does not affect.

Children. 200 mg powder: used in children over 2 years of age.

600 mg powder: used in children over 14 years of age.

simultaneous use of acetylcysteine with antitussives may increase sputum stagnation due to a decrease in the severity of the cough reflex.

When used simultaneously with antibiotics such as tetracycline (except for doxycycline), ampicillin, amphotericin B, cephalosporins, aminoglycosides, they may interact with the thiol group of acetylcysteine, which leads to a decrease in the activity of both drugs. Therefore, the interval between the use of these drugs should be at least 2 hours. This does not apply to cefixime and loracarbef.

Activated carbon reduces the effectiveness of acetylcysteine.

Acetylcysteine reduces the severity of the hepatotoxic effect of paracetamol.

There is a synergism between acetylcysteine and bronchodilators.

Acetylcysteine can be a cysteine donor and increase glutathione levels, which helps detoxify oxygen free radicals and certain toxic substances in the body.

The simultaneous use of nitroglycerin and acetylcysteine can lead to an increase in the vasodilatory effect of nitroglycerin.

Upon contact with metals or rubber, sulfides with a characteristic odor are formed, so glassware should be used to dissolve the drug.

there are no data on cases of overdose with oral administration of acetylcysteine.

Symptoms: nausea, vomiting, diarrhea. Children are at risk of developing hypersecretion.

Therapy symptomatic.

at a temperature not exceeding 25 °C. Keep out of the reach of children.