Treatment regimens for chlamydia. Treatment of chronic chlamydia: drugs, dosage regimen Polyoxidonium for chlamydia treatment regimen

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Features of the treatment of chlamydia.

• The sooner it starts chlamydia treatment, the more effective it is.
• It is imperative that all sexual partners of the patient be examined and, if chlamydia is detected, treated (even in the absence of symptoms).
• With inadequate antibiotic therapy for chlamydia, the disease may progress to a chronic stage with the formation of antibiotic-resistant L-forms.
• There is no single treatment regimen for chlamydia. Antibiotic therapy is mandatory. And the use of immunomodulators, enzymes, hepatoprotectors and other drugs is considered individually.
• Good nutrition and a healthy lifestyle are essential for recovery. During the treatment period, it is not recommended to engage in sexual activity; drinking alcohol is strictly prohibited. It is necessary to temporarily avoid spicy food. You should also refrain from excessive physical activity.

In the treatment of chlamydia, 3 main groups of drugs are used.

1. Antibiotics: tetracyclines, macrolides, fluoroquinolones.
2. Immunomodulatory drugs.
3. Systemic enzyme therapy drugs.

1. Antibacterial drugs.
When prescribing antibiotics for chlamydia, the following circumstances must be taken into account:

Today, in the treatment of chlamydia, it is most rational to use 3 groups of antibiotics: tetracyclines, macrolides, fluoroquinolones.

a) Tetracyclines
Doxycycline (vibramycin, unidox solutab). The first dose is 0.2 g, then for two weeks 2 times a day, 0.1 g. The course should be 2.5 - 4 g of the drug. Disadvantages: side effects: nausea and vomiting, rarely - impaired bone formation, defects in tooth enamel. The use of tetracyclines is contraindicated during pregnancy and breastfeeding and in children under 14 years of age. Unidox Solutab and vibramycin are better tolerated than doxycycline.

b) Macrolides.
Macrolides are the safest antibiotics. They have a minimum of side effects and are well tolerated. All of them are active against treponema pallidum, mycoplasma, ureaplasma, and gonococcus, which allows them to be used for mixed infections. The effectiveness of macrolides, according to experts, reaches 91-97%.

• Erythromycin. Its effectiveness is 85% - 95%. Disadvantages: severe dyspeptic disorders and the need for 4 doses. Use 500 mg 4 times a day for 2 weeks.
• Vilprafen (josamycin). It is considered the most effective in most cases and the safest. For a fresh form of chlamydia - 500 mg 2 times a day for 2 weeks. For chronic - 500 mg 3 times a day for 4 weeks. The initial dose is 1 g once. Resistance to josamycin develops less frequently than to other antibiotics from the macrolide group.
• Rovamycin (spiromycin). Prescribed 3 million units 3 times a day for 2 weeks.
• Rulid (roxithromycin). Use 150 mg 2 times a day for 2 weeks.
• Macropen (midecamycin). Prescribed 400 mg 3 times a day for 2 weeks.
• Sumamed (azithromycin). Prescribed according to the following scheme: the first day 1 g once, then 0.5 g for 7 days. The course is designed to take 3 g of the drug. Recently, resistance of chlamydia to sumamed has been noted. Therefore, you can replace it with Chemomycin, the active ingredient of which is also azithromycin.
• Klacid (clarithromycin). Take 250 mg twice daily for 2-3 weeks.

During pregnancy, it is allowed to use erythromycin 500 mg 4 times a day for 2 weeks or rovamycin 3 million units 3 times a day for 2 weeks.

c) Fluoroquinolones.
They are less effective than macrolides and tetracyclines. However, they are active against gonococcus, mycoplasma, and gardnerella. Contraindicated during pregnancy, as well as in children under 14 years of age. They have a significant number of side effects.

• Ofloxacin (zanocin, tarivid) 200 mg after meals 2 times a day for 10 days.
• Abactal (pefloxacin). Fresh and uncomplicated chlamydia - 400 mg twice a day for 1 week. Chronic form – 10-12 days.
• Maxaquin (lomefloxacin). For a fresh, uncomplicated form - 400 mg once a day for a week. For chronic use - 400-600 mg/day, course 28 days.
• Tsiprobay, Tsiprolet, Tsifran (ciprofloxacin). For fresh, uncomplicated forms of chlamydia, 500 mg is taken at the first dose, subsequent doses are 250 mg twice a day for 7 days. For chronic and complicated forms - 500 mg twice a day for 12 days.

2. Immunomodulatory therapy.
With chlamydial infection, suppression and changes in the state of the immune system occur, which creates the basis for the chronicization of the process. Therefore, during treatment it is necessary to act not only on the pathogen itself, using antibiotics, but also to increase the body’s resistance, strengthening the immune system. However, immunomodulators are not always used - in each specific case individually.

The following immunomodulators are used:

• Immunomax. The recommended dose for adults is 100-200 U IM 1 time/day. Course of treatment – ​​6 injections on days 1, 2, 3, 8, 9, 10 of treatment.
• Polyoxidonium. It is used to treat atypical forms of chlamydia in cases of impaired immunological status. Polyoxidonium increases the formation of antibodies and the body's immune resistance. Used in a course of 10 injections of 6 mg every other day.
• Erbisol. 2 injections per day: 2 ml in the morning at 8 o’clock and in the evening at 22 o’clock, course 20 days. It also protects the liver, being a hepatoprotector.

3. Systemic enzyme therapy.
Preparations for systemic enzyme therapy normalize the permeability of cell membranes in areas of inflammation. Thus, higher concentrations of antibiotics penetrate into the cell at lower doses. They enhance the effect of antibiotics, increasing their concentration in the blood serum by 20-40%. They block mechanisms that trigger allergic (including to medicinal drugs) and autoimmune reactions, accelerate the elimination of toxins, and provide decongestant and analgesic effects.

Preparations:

• Wobenzym. Prescribed 3 tablets. 3 times a day 30 minutes before meals, with a glass of water, course 2-4 weeks.
• Phlogenzyme. Prescribed 2 tablets. 3 times a day 30 minutes before meals, with a glass of water, course 2-4 weeks.

4. Hepatoprotectors.
The prescription of this group of drugs is due to the long-term use of antibiotics, which are metabolized in the liver, creating an increased load on it. Moreover, tetracyclines and fluoroquinolones are hepatotoxic and can cause liver damage. Preparations:

• Essentiale - 2 caps. 2-3 times a day with meals, course 2-4 weeks
• Karsil - 70 mg 3 times a day after meals, course 2-4 weeks
• Legalon - 70 mg 3 times a day after meals, course 2-4 weeks

5. All other groups of drugs are used individually.
If dysbacteriosis has developed, use eubiotics Bifidumbacterin, Acylact, etc.
Vitamins and antioxidants may also be prescribed.

How to make sure that you are cured?
The disappearance of clinical manifestations of chlamydia after a course of treatment is not proof that the body has gotten rid of the pathogen. Sometimes the use of antibiotics leads only to local improvement. Therefore, a month after completion of antibiotic therapy, it is necessary to conduct control tests. If chlamydia is not found, then repeated tests are carried out after a month. If after a month the tests for the presence of chlamydia are negative, only then will it be possible to talk about the effectiveness of the treatment.

The following laboratory tests are used:

• ELISA for IgA - there is no IgA during recovery.
• PCR – upon recovery, PCR is negative.
• All other laboratory diagnostic methods are uninformative.

In the treatment of chlamydia, the main (basic) element is antimicrobial agents (antibiotics).

However, such therapy must necessarily be supplemented by the use of immune drugs, enzyme therapy, the use of vitamins and antioxidants, hepatoprotectors and probiotics.

The permeability of cell membranes for most antibiotics is quite low; their concentration inside the cell does not reach the level that is created in the blood, and makes it possible to effectively fight other infections. Therefore, chlamydia, which was treated with antimicrobial agents, often reappears after some time.

The problem is that most patients have chronic urogenital chlamydia, against which antibiotics are often ineffective.

Antibiotics for chlamydia

How to treat chlamydia with antibiotics?

When choosing an antibiotic, laboratory tests are required to determine the sensitivity of the pathogenic microorganism to a specific antibacterial drug.

The duration of antibiotic treatment and individual dosage are determined only by the doctor.

Antimicrobial drugs (antibiotics) and the scheme of their use for chlamydia:

Treatment of infection must necessarily include immune drugs, since stimulation of the immune system is the most important component in the treatment of any sexually transmitted diseases. If there is no powerful immune response to the invasion of microbes into the body, no antibiotic will provide a complete cure.

The following immune drugs are used to stimulate the immune response for chlamydia:

Enzyme therapy is one of the methods of effective treatment of invasion using specially formulated mixtures of highly active animal and plant enzymes, which have a positive effect on restorative (healing) processes, as well as on the body’s immune response. The use of enzymes allows us to achieve maximum concentrations of antibiotics at sites of infection. Enzyme preparations help stimulate the function of the kidneys and liver, reducing intoxication of the body.

The following drugs are used for enzyme therapy for chlamydia:

Vitamins and antioxidants

Vitamin complexes and antioxidants are also an important component of treatment, because their use enhances the body's immune response to chlamydia invasion.

The following vitamins and antioxidants are used for chlamydia:

Hepatoprotectors

For chlamydia, the following hepatoprotectors are used:

Probiotics

In order to prevent antibiotic-associated diarrhea and intestinal dysbiosis, it is recommended to take probiotic preparations (probiotics) after antibiotic therapy.

The following probiotics are used for chlamydia:

Complementary therapies and procedures

As part of complex therapy for chlamydia, the following is used:

Physiotherapy: ultrasound treatment, magnetic laser, magnetic therapy, iontophoresis or electrophoresis with drugs.

Local therapy: vaginal suppositories, tampons, rectal suppositories, microenemas with medicinal herbs.

Strict diet and diet: avoiding alcohol, spicy foods, confectionery, avoiding sexual contact and excessive physical activity.

Treatment regimen for acute and chronic chlamydia

Treatment regimens and drugs depend on the clinical symptoms of the disease, the severity of the process, the duration of the disease, the age of the patient and concomitant diseases.

Scheme for acute chlamydia

In acute cases of the disease in combination with another bacterial infection, the following regimen is recommended:

Basic therapy: antibiotics - doxycycline (vibramycin, unidox) 100 mg 2 times a day for 21 days, immune drugs - amixin, polyoxidonium, vitamin therapy. After a week, it is necessary to add systemic enzyme therapy.

Restorative procedures: physiotherapy - laser magnetic and ultrasound effects, microenemas, baths with chlorhexidine or perftoran solution. According to indications, hepatoprotectors and probiotics can be prescribed. Longidaza is used - 1 suppository per day for 10 days.

Scheme for chronic chlamydia

For the chronic course of the disease, the following treatment regimen for chlamydia is used:

Preparatory activities: inductotherapy of affected organs for 14-21 days, immune drugs - amixin for a month according to the scheme or polyoxidonium intramuscularly 6 mg 10 injections every other day. Systemic enzyme therapy for 14 days according to the scheme, local therapy in the form of microenemas, baths with chlorhexidine solution are also recommended.

Basic therapy: begins 10 days after the start of the preparatory stage - doxycycline or vilprafen, as well as antimycotics if indicated for their use, multivitamins.

Restoration activities: physiotherapy, hepatoprotectors. Hyaluronidase preparations are very effective. This is lidase 64 units. every other day No. 15, longidaza 1 suppository per day for 10 days, or 1 injection every other day. Bificol 2 times a day 5 doses for a month. Local therapy - baths, microenemas with perftoran solution, vaginal tampons with eubiotics, antioxidants.

Folk remedies for chlamydia

The most effective folk remedies that help with chlamydia are chamomile flowers, calendula, birch buds and leaves, licorice root, rhubarb root, garlic, and hogweed.

Garlic It is widely used to treat a variety of diseases, thanks to the phytoncides contained in its composition. Garlic is a natural antibiotic, so to combat chlamydia at home, it is recommended to prepare garlic tincture. To do this, mix 200 ml of water with 5-6 cloves of garlic, chopped into a fine paste. Infuse the mixture for 12 hours, strain, and then use for local douching or lubricating affected mucous membranes. Garlic tampons are very effective.

Anti-inflammatory herbs. You need to take 2-3 tablespoons of dry raw materials (chamomile, calendula, licorice root, yarrow, birch buds, oak bark) and pour a liter of boiling water. Leave the decoction for about 40 minutes, strain and take 100 ml of decoction each time an hour before meals. It is recommended to take herbal decoctions for 3-4 weeks in a row. Such remedies effectively strengthen the immune system and speed up recovery.

Universal herbal collection for compresses, douching and oral administration. To do this, you need to take equal parts of celandine, St. John's wort, yarrow, bird cherry fruits, wormwood seeds and walnut leaves. Grind all the ingredients, dry them and prepare decoctions from them in a water bath, using 30 g of the mixture per 500 ml of water.

St. John's wort has a powerful strengthening effect on the body. Every day you can drink restorative tea made from St. John's wort three times a day with the addition of other medicinal herbs.

Hog queen. The most effective tincture is made with vodka, alcohol, cognac: 100 g of raw material per 0.5 liter must be infused in a dark place for 7-10 days, stirring. Apply 0.5-1 tsp. (or 25–30 drops) 3-4 times a day. The course of treatment can range from two to three months to one to four years (with interruptions, of course).

Parapharmaceuticals for chlamydia

A new approach to the fight against chlamydia is the use of modern highly effective parapharmaceuticals.

A striking example of this class of drugs is Biphysim. The drug was developed and produced by the Novosibirsk Center for Pharmacology and Biotechnology.

The main purpose of the drug is natural immunomodulation, aimed at increasing the human body’s resistance to the effects of pathogens. It is an active means of restoring reduced and lost functions of the immune system.

Biphysim also enhances the production of its own interferons, normalizes the composition of intestinal microflora, and helps eliminate inflammatory processes and immunodeficiency conditions.

The drug is built on a modular principle. The capsules contain two biomodules: fragmented salmon DNA and bifidobacteria fermentolysate.

Directions for use and dosage: Orally 30-40 minutes before meals, 2 capsules 2 times a day. The course of treatment is 17-21 days.

Both tablet preparations for oral use and suppositories for local use are used. Treatment of the disease involves the use of suppositories that belong to different pharmacological groups. This is explained by the fact that pathogens very quickly develop resistance to drugs.

Suppositories are good at eliminating the unpleasant symptoms that accompany the infection. The rapid disappearance of burning and itching significantly alleviates the condition of patients.

According to the method of application, vaginal and rectal suppositories are distinguished. The first are introduced into the vagina and have an effect on the epithelial cells of the female genital organs. The second ones should be inserted into the rectum. There they are absorbed through the mucous membranes, after which the components of the drug enter the bloodstream.

Depending on their composition, suppositories are divided into two types:

1. Immunomodulators(Polyoxidonium, Viferon, Genferon). They have a stimulating effect on the body, helping to strengthen its protective functions.
2. Antiseptic(Hexicon, Betadine, Amident, Iodoxin, Povidone-Iodine). These are medications with a narrow spectrum of action that neutralize infectious pathogens directly. The active substances of suppositories penetrate chlamydia cells, disrupting their activity and preventing reproduction.

Important! All suppositories can be found and purchased in pharmacies without a prescription.

Treatment regimen for chlamydia

Suppositories must be used according to a certain scheme, following certain rules. Here are the most basic of them:

1. At the initial stage of therapy, suppositories with antiviral properties are prescribed, which effectively cope with pathogenic bacteria. These include Genferon and Hexicon.
2. Treatment of the disease with suppositories with an immunostimulating effect continues. They trigger a defense mechanism to fight infectious pathogens. Viferon is suitable for these purposes.
3. The therapeutic course lasts on average from one to three weeks.
4. After treatment, the patient undergoes tests. If necessary, therapy continues, but with a reduction in dosage.

Review of popular candles

There are a number of drugs that are most actively used in medical practice for the treatment of chlamydia.

The active ingredient of the drug is human recombinant alpha 2b interferon. Additional components: ascorbic acid and vitamin E. Tocopherol, as a powerful antioxidant, promotes cellular regeneration and provides protection against free radicals.

These suppositories have pronounced immunomodulatory and antiviral properties. In addition, Viferon stimulates the cytotoxic function of lymphocytes and increases the phagocytic activity of macrophages. The combination of all the properties of the drug helps to powerfully strengthen the immune system and suppress the uncontrolled growth of abnormal cells.

Viferon has virtually no negative side effects, despite its high therapeutic effectiveness.

Suppositories are administered rectally. The specific dosage and treatment regimen is selected by the doctor. The standard course is designed for daily use of one suppository for ten days.

This medicine is suitable for long-term therapy.

Cost - 250-380 rubles.

Betadine

These are suppositories that have a wide spectrum of activity. They have antiseptic and antimicrobial properties. The active component is povidone-iodine, and the auxiliary component is macrogol. Betadine is effective against many bacteria, fungi and viruses. One package contains 7 candles, torpedo-shaped and dark brown in color.

Restrictions on use:

• treatment with iodine-containing medications;
• irritated vaginal mucosa;
• itching and peeling on the labia;
• pathologies of the thyroid gland;
• allergy to iodine.

Note! During the therapeutic course, it is better to use sanitary pads, as the remains of the candles can leak out and stain your underwear.

This is an inexpensive and accessible product, the cost of which is about 300 rubles.

The effect of suppositories is based on the destruction of bacterial cells due to the destruction of their membranes. The introduced candle dissolves, turning into a thin protective film. The drug is not absorbed into the bloodstream, but acts exclusively locally.

The lack of toxic properties of suppositories allows them to be prescribed during pregnancy and during breastfeeding. Chlorhexidine does not have any negative effect on intrauterine development of the fetus.

The average price of a medicine is 250-300 rubles.

Genferon

This drug belongs to the group of interferons. It also contains benzocaine and taurine. The medicine has antibacterial, antiviral and immunomodulatory properties. It effectively eliminates inflammatory foci by inhibiting antigenic cells. The effectiveness and safety of this unique drug has been confirmed by clinical studies. Benzocaine reduces the sensitivity of nerve endings and reduces pain. Taurine normalizes metabolism in tissues, stimulates regeneration and acts as an antioxidant.

Suppositories are available in dosages of 250 thousand, 500 thousand, and 1 million IU.

Suppositories are used rectally and vaginally. The active components are absorbed through the mucous membranes and penetrate the lymph and tissues, producing a systemic effect. Part of the drug remains on the mucous membranes, exerting a local effect. The medication is used twice a day.

Side effects sometimes include allergies, headaches, poor appetite, increased sweating and joint pain.

The estimated cost of Genferon is 300-500 rubles.

These are candles with strong disinfectant, antifungal, antiseptic and bactericidal properties. They contain 200 mg of active ingredient. The drug affects pathogens by releasing iodamines. They lead to the death of the infectious pathogen.

These suppositories are water-soluble and therefore do not irritate the mucous membranes.

Povidone-Iodine suppositories are intended for intravaginal use only (once or twice a day).

The average price is 60-70 rubles.

Polyoxidonium

The medicine belongs to the interferons, at the same time acting as an antiseptic. Its active component is azoximer bromide. It stimulates the processes of the emergence of new cells, as a result of which phagocytes and leukocytes fight chlamydia more effectively. Excipients: povidone K17, mannitol, cocoa butter.

Polyoxidonium is well tolerated by patients without causing allergic reactions.

The drug is able to enhance the activity of antibacterial agents, ensuring the cure of chlamydia in the shortest possible time.

Release forms: rectal and vaginal suppositories of light yellow color.

The only disadvantage that can be noted is the high cost of the medicine. Estimated price - 900-1000 rubles.

Using suppositories during pregnancy

If detected, treatment is always carried out in the most gentle way. A number of candles are strictly prohibited for use. These include Polyoxidonium, Iodine-Povidone and Betadine. They can cause miscarriage or serious pathologies in the fetus.

Among the approved medications, mention should be made of Hexicon. These suppositories are absolutely safe and are allowed even in the first months of pregnancy.

The use of Genferon and Viferon is possible from a later date, from 12 and 14 weeks, respectively.

How long does the therapeutic course last?

The duration of treatment depends on the severity and nature of the chlamydial infection. At a minimum, therapy lasts one week, at a maximum - 21 days. After completing the course, the patient must undergo tests to ensure that the infection has disappeared.

Note! The chronic form of the disease is difficult to treat. It may last for a longer period (up to four months).

Compatibility with other drugs

Suppositories are usually well compatible with other pharmacological drugs. Simultaneous use of medications with antimicrobial activity and interferon suppositories enhances the effectiveness of treatment.

Interferons also work better when used in conjunction with products containing tocopherol or vitamin C.

Contraindications to the use of candles

Self-prescription of suppositories is unacceptable; they are selected only by the attending physician. This is due to the fact that most medications have contraindications for use. Here is a list of the most common ones:

• acute renal failure;
• liver pathologies;
• pregnancy period;
• allergic and autoimmune diseases in the acute stage;
• personal intolerance to components.

Frequent side effects:

• curdled discharge;
• changes in vaginal microflora;
• hyperemia (redness);
• burning and itching.

Local treatment does not always help cope with the infection. In such cases, the use of suppositories in the treatment of chlamydia is best combined with oral tablets. This will be much more effective and will lead to a faster recovery.

In this video, a venereologist talks about the treatment of chlamydia.

Suppositories for chlamydia in women are available in pharmacies without a doctor's prescription. But before using these medications, you need to consult a gynecologist.

If the disease is diagnosed in a representative of the fair sex, suppositories are inserted into the vagina. When treating men, suppositories intended for rectal use are used.

Symptoms of chlamydia in women

Symptoms of chlamydia in women

The incubation period for chlamydia is about 14 days. After this period, the fair sex may experience the first symptoms of the disease:

• Weakness;
• The appearance of itching in the genital area;
• Burning when urinating;
• Pain in the lower abdomen;
• The appearance of discharge accompanied by an unpleasant odor.

In the latent form of chlamydia, the characteristic symptoms of the disease may be absent for a long time, so a woman often finds out about the presence of chlamydia only at her next gynecological examination.

Side effects of suppositories

Some suppositories for the treatment of chlamydia may cause the following side effects:

• Itching in the vagina;
• Burning;
• The appearance of vaginal discharge.

The listed side effects usually disappear within a few days after stopping the medication.

Interaction with other drugs

Most vaginal suppositories for chlamydia interact well with other medications used in the treatment of the disease (antibiotics, immunomodulators).

When using drugs containing interferon, the effectiveness of antiviral drugs increases. The effect of such medications is enhanced when combined with medications that contain tocopherol or ascorbic acid.

Storage conditions for suppositories

Chlamydia suppositories should be stored in a cool place, at a temperature from +2°C to +8°C. Medicines cannot be frozen. The average shelf life of the drugs is approximately two years. Suppositories should be kept out of the reach of children.

Suppositories "Polyoxidonium" against chlamydia

Candles "Polyoxidonium"

In the treatment of the disease, Polyoxidonium suppositories are used. They increase the body's resistance to infectious diseases. Thanks to suppositories, antibodies are actively produced, which have a beneficial effect on the immune system. "Polyoxidonium" enhances the therapeutic effect of antibiotics, accelerating the healing process.

The drug "Hexicon" for the treatment of the disease

The drug "Hexicon"

Hexicon suppositories contain chlorhexidine. The drug helps neutralize the activity of both gram-negative and gram-positive organisms. The medicine is not capable of causing harm to the body during pregnancy and breastfeeding. The antiseptic does not have a negative effect on the vaginal microflora.

Suppositories "Betadine"

Suppositories "Betadine"

The medication has virtually no contraindications. But the drug should not be used if you are hypersensitive to its components. The use of Betadine should be avoided if a woman has renal failure or thyroid pathologies. The use of the drug during pregnancy should be discussed with your doctor individually.

In addition to suppositories, there is also Betadine ointment. This product is used to treat bedsores, abrasions, deep cuts and trophic ulcers. The ointment is applied to the surface of the wound. It is applied in a thin layer. After which a bandage is applied to the body. It is recommended to treat wounds twice a day for two weeks.

Suppositories are used in the treatment of chlamydia, bacterial vaginosis, and genital herpes. In most cases, one suppository per day is prescribed. The suppositories are inserted deep into the vagina. The drug can be used on any day of the menstrual cycle. The duration of treatment is seven days. If necessary, the treatment course can be extended. By agreement with the doctor, the daily dosage can be doubled.

The drug "Genferon" for chlamydia

The drug "Genferon"

The drug "Genferon" is actively used in the treatment of various diseases of the genitourinary system in men and women. The product helps fight viruses, bacteria, fungi. The drug improves the condition of the immune system. It increases the body's resistance to external irritants.

There are the following indications for the use of the medicine:

• Vaginitis;
• Cervicitis;
• Trichomoniasis;
• Cervical erosion;
• Chlamydia;
• Mycoplasmosis.

The drug contains interferon, which increases human immunity. The drug also contains benzocaine. This substance allows you to get rid of pain.

The suppositories contain taurine, which accelerates the process of tissue regeneration. This substance has anti-inflammatory properties; it neutralizes the activity of free radicals. Taurine can enhance the effect of interferon.

The drug should not be used if you are hypersensitive to the components of the product.

Effective remedy "Iodoxide"

Iodoxide

The drug "Iodoxide" has pronounced antiseptic properties. The medicine contains iodine in combination with povidone. The product has a bactericidal effect on the body. The medication is used in the complex treatment of bacterial vaginosis and chlamydia. It is also used to prevent complications when preparing for the following medical procedures:

• Installation of an intrauterine device;
• Diathermocoagulation of the cervix;
• Artificial termination of pregnancy.

The use of Iodoxide should be avoided in case of hypersensitivity to the active ingredients of the drug. The medicine is contraindicated for thyroid adenoma and thyrotoxicosis. If a representative of the fair sex has renal failure, the drug should be used with caution. Before using the medicine during pregnancy and breastfeeding, you should consult a doctor.

Herbal preparation Intoxic Plus in combination with suppositories

Vaginal suppositories prescribed for chlamydia go well with the herbal preparation Intoxic Plus. It has a pleasant taste and no unpleasant odor. The product helps fight viruses and other harmful organisms. The drug improves the functioning of the cardiovascular system, kidneys and other organs. The product promotes weight loss.

Intoxic Plus contains the following ingredients:

• Sumac fruits. Their juice has long been known for its anti-inflammatory and antiseptic properties. The drink is rich in antioxidants that help strengthen the immune system.
• Ferula jungarica. It contains a lot of useful substances. Ferula jungarica is used for poisoning and the treatment of infectious diseases. It helps cope with allergies and has a beneficial effect on the cardiovascular system. Ferula jungarica is endowed with sedative properties and normalizes sleep.
• Bear bile. This component helps remove harmful substances from the body.
• Artemia extract. This substance helps restore metabolic processes in the body.

Currently, one of the central problems of infectious pathology is the problem of urogenital infections, among the causative agents of which is the intracellular microbe Chlamydia trachomatis. This article presents data on the clinical and immunological effectiveness of the immunomodulator polyoxidonium in the treatment of urogenital infections.

Mechanism of action of polyoxidonium. Polyoxidonium (PO) is a unique polymer molecule that has a multifaceted positive effect on the human body. This effect consists of immunomodulatory, detoxifying, antioxidant, and membrane-stabilizing effects.

The immunomodulatory effect is associated with the ability of polyoxidonium to normalize the functional activity of cells of the monocyte-macrophage system, the activation of cells of which leads to an increase in the functional activity of almost all parts of the body’s defense against infection:

• natural resistance factors: neutrophils, monocytes, macrophages, NK cells;
• factors of acquired immunity: humoral and cellular.

The detoxifying effect is associated with the peculiarities of the chemical structure of polyoxidonium, which, being a high-molecular substance, contains a large number of active groups on its surface. Because of this, polyoxidonium has the ability to sorb various toxic substances, including microbial ones.

The antioxidant and membrane-stabilizing properties of polyoxidonium are also closely related to the characteristics of its chemical structure.

Polyoxidonium is available in the form of lyophilized powder for injection and suppositories.

Clinical effectiveness of suppositories in the treatment of urogenital infections. The development of non-invasive methods for treating diseases is an urgent task in medicine. The creation and introduction into medical practice of a dosage form of polyoxidonium in the form of suppositories can be considered a great scientific achievement. This form of the drug was used in some medical institutions in Russia for the treatment of urogenital infections. Doses of the drug were 3, 6 and 12 mg. Doses of 6 and 12 mg had approximately the same effectiveness in terms of eliminating the pathogen, while at a dose of 3 mg the drug, although it had a positive effect, was less pronounced than in previous cases. These data were the basis for the further use of suppositories at a dose of 6 mg.

Chlamydia. The use of suppositories in a dose of 6 mg revealed the high clinical effectiveness of the drug in women with chlamydia in combination with chronic salpingoophoritis and unilateral hydrosalpinx; in patients with endocervicitis against the background of trichomoniasis, with ureaplasmosis, gardnerellosis, mycoplasmosis in combination with ureaplasmosis. Identification of the pathogen was carried out using direct immunofluorescence. Patients received suppositories (No. 10) daily for the first three days and then at intervals of 48 hours. Treatment was carried out against the background of antibacterial therapy.

As a result, after the inclusion of software in complex therapy, clinical recovery and complete elimination of pathogens occurred in 96% of patients. There were not a single case of toxic or side effects from the action of suppositories. Their use made it possible to reduce treatment time by 1.5 times.

Nonspecific colpitis and cervicitis. In this study, patients received suppositories every day for 10 days at a dose of 6 mg. After taking the first two suppositories, all patients noted the disappearance of itching and burning, the cessation of discharge and discomfort. By the end of taking the drug, these symptoms disappeared completely. During colposcopy, the disappearance of swelling and hyperemia was noted, the mucous membrane of the vagina and the vaginal part of the cervix acquired the usual pale pink color. During bacteriological examination before treatment, the degree of vaginal contamination reached 107-109 CFU/ml. Among the microbes, Staphylococcus aureus and Staphylococcus epidermidis, Escherichia coli, Proteus, and anaerobes predominated. After treatment with suppositories, the vaginal microflora was normalized: the number of bacteria was 103-104/ml. The positive clinical dynamics coincided with an improvement in both local and systemic immunity. In the first case, there was an increase in the functional activity of vaginal macrophages; in the second case, an increase in CD4+ T helper cells in the blood was observed.

The results of intravaginal use of suppositories in HIV-infected women with symptoms of nonspecific colpitis and cervicitis turned out to be very convincing. These patients received suppositories with polyoxidonium in combination with basic therapy according to the above regimen.

It was found that intravaginal use of polyoxidonium in the complex treatment of HIV-infected patients led to a significant reduction in the viral load in the blood. Per 107 blood cells, the amount of virus decreased from 985 genomes to 151. The viral load of macrophages of the vaginal mucosa decreased similarly: from 344 genomes to 38 genomes per 107 cells. In the control group of women who received only basic therapy, the decrease in the viral load on blood cells was much less pronounced, and in resident vaginal macrophages it was practically absent.

Prostatitis. During the study, suppositories were used at a dose of 6 mg daily for 10 days in 15 patients with chronic chlamydial prostatitis. In all patients, after the course of treatment, clinical complaints completely disappeared: pain and cramping in the urethra stopped, pain and discomfort in the perineum, urethral discharge disappeared, and an erection was restored. In a control study carried out a month later using the polymerase chain reaction method, chlamydia was detected in only one of 15 patients.

When studying the effectiveness of treatment of prostatitis using direct immunofluorescence, 2 months after completion of a course of intrarectal use of polyoxidonium according to a similar scheme in 30 patients (96% of cases), complete elimination of the pathogen from the pathological material was established. An echography of the prostate showed an improvement in its structure, a normalization of the microscopic picture of the prostate and an improvement in ejaculate parameters. An immunological study revealed an increase in the number of T-helper cells and IgA in the peripheral blood.

Thus, it can be argued that suppositories with polyoxidonium are highly effective in the complex treatment of urogenital infections. Considering this circumstance, as well as the complete absence of side effects in this form of the drug, the Pharmacological Committee has now authorized the over-the-counter dispensing of polyoxidonium in the form of rectal suppositories.

Clinical effectiveness of the injectable form of polyoxidonium in the treatment of urogenital infections. For urogenital infections, the injectable form of polyoxidonium, as well as suppositories, was used in three doses: 3, 6 and 12 mg. A dose of 3 mg was not effective enough. Doses of 12 and 6 mg showed approximately the same effectiveness. Therefore, a dose of 6 mg can be considered the main one for the treatment of urogenital infections using injections. The use of polyoxidonium in this form has proven itself well in the complex treatment of chlamydial urethritis, prostatitis, cervicitis, salpingo-oophoritis, trichomanasic urethritis, and genital herpes. The effectiveness of polyoxidonium can be confirmed by complete clinical recovery and the disappearance of pathogens from pathological material in 95% of patients in the main group; in the control group this proportion was 70-75%. In addition, the use of polyoxidonium in combination with other therapeutic measures made it possible to halve the treatment time, significantly reduce the dose of antibiotics consumed, and reduce the frequency of distant relapses of the disease.

Chlamydial urethritis and prostatitis. A group of 17 patients received the drug at a dose of 6 mg intramuscularly: the first 2 injections daily, then 2 times a week; In total, the course consisted of 7 injections. During a cultural examination of patients a month after the end of treatment, chlamydia was not detected in 15 people. In 2 patients the usual forms of Ch. trachomatis were found. As is known, these forms are sensitive to antibiotics, and therefore this indicator can be regarded as positive. An immunological study revealed an increase in the level of natural killer cells (CD16/56+), which, as is known, play a leading role in protecting the body from intracellular pathogens. An increase in the level of immunoglobulins IgA and IgM was also observed. Let us recall that IgA plays an important role in protecting mucous membranes from infectious agents.

Trichomonas urethritis. We observed 45 patients whose diagnosis of trichomonas urethritis was made on the basis of a morphological examination of scrapings from the urethra using a microscopic method and using PCR. 23 people received etiotropic chemotherapy drugs (metronidazole, ornidazole or nimorazole) in combination with polyoxidonium (3 times a week intramuscularly, 6 mg), 22 patients received only chemotherapy drugs without polyoxidonium. After completing the course of treatment, Trichomonas were not detected in scrapings from the urethra in all patients of the first group. Clinical recovery was observed in 19 people. After a second course of treatment, recovery occurred in 3 people. In the second group, after the course of treatment, a clinical effect was noted only in 13 people. 9 patients underwent a repeated course, after which recovery was achieved in 5 cases. Thus, the clinical observations indicate the effectiveness of polyoxidonium in the complex treatment of Trichomonas urethritis.

Endolymphatic use of polyoxidonium for chlamydial prostatitis. Direct endolymphatic administration of PO was carried out in 12 patients through a microcatheter installed in the peripheral lymphatic vessel of the lower limb. The drug was administered every other day at a dose of 6 mg, the course was 5-6 injections. In this case, after completing the course of treatment, significant improvement was noted. Elimination of chlamydia from the prostate occurred in 96% of cases. The picture of her secretion improved significantly. There was an increase in T-helper cells (CD4+) and IgA in the blood. Probably, this method of administering PO should be kept in mind when it comes to advanced cases of chronic prostatitis that are difficult to treat with conventional methods.

Individual observations of practicing physicians indicate the possibility of using the injectable form of polyoxidonium as monotherapy. However, at present it is premature to talk about the use of polyoxidonium for urogenital infections in the form of monotherapy; this requires further accumulation of factual material.

The main tactics for using polyoxidonium. For different diseases, different dosages and regimens for using polyoxidonium are accepted, but the approximate dosage for adults can be formulated as follows: 6 mg every 1-2 days No. 7-10. This regimen is recommended for the treatment of chronic infectious and inflammatory processes of various localizations, including urogenital infections. Depending on the severity of the pathological process, the number of injections can be increased to 15. In order to quickly relieve pathology in acute processes and septic conditions, the first dose of polyoxidonium can be increased to 12 mg. In these cases, it is also possible to administer the first two doses of polyoxidonium daily.

Polyoxidonium interacts well with all antimicrobial drugs, interferons and their inducers. It has the ability to have an enhancing effect on the action of the main etiotropic drugs of basic therapy. The simultaneous use of polyoxidonium and an antimicrobial drug deals a double blow to the pathogen, as a result of which a good clinical effect is achieved.