Rennie while breastfeeding. Rennie - complete instructions Rennie contraindications

RENNIE'S INSTRUCTIONS

Pharmachologic effect:
The drug has an antacid and gastroprotective effect. The active components of the drug are calcium and magnesium carbonate. These compounds, entering the stomach cavity, interact with hydrochloric acid, which is part of the gastric juice. As a result of a chemical reaction, the acid is neutralized with the formation of water and water-soluble calcium and magnesium salts. Under the influence of magnesium, mucus production and protection of stomach cells from the negative effects of hydrochloric acid increases. The drug has a rapid therapeutic effect in case of increased acidity and pain caused by excess hydrochloric acid. When administered orally Rennie systemic absorption of calcium is about 10%, and magnesium is about 15-20%. Calcium and magnesium that enter the systemic circulation are excreted by the kidneys; in patients with impaired renal function, the excretion of calcium and magnesium is slightly reduced.

Indications for use

Mode of application

Side effects

Contraindications

Pregnancy

Interaction with other drugs

Overdose

Release form

Storage conditions

Compound

1 tablet Rennie with menthol flavor contains:
Calcium carbonate - 680 mg;
Magnesium carbonate - 80 mg;

1 tablet Rennie orange flavored contains:
Calcium carbonate - 680 mg;
Magnesium carbonate - 80 mg;
Excipients, including sucrose (475 mg).

RENNIE PRICE:
21.85 UAH

Main settings

White, off-white, square tablets with concave surfaces, engraved RENNIE on both sides, with the scent of orange.

Active ingredients

Release form

Pills

Compound

1 tablet contains active ingredients: calcium carbonate 680 mg, basic magnesium carbonate (magnesium hydroxycarbonate) 80 mg. Excipients: sucrose 475 mg, pregelatinized corn starch 20 mg, potato starch 13 mg, talc 33.14 mg, magnesium stearate 10.66 mg, liquid paraffin 5 mg, orange flavor (orange oil, maltodextrin, purified water) 35.2 mg, sodium saccharinate 2 mg.

Pharmacological effect

Local antacid drug. Rennie tablet contains antacid substances - calcium carbonate and magnesium carbonate, which provide rapid and long-lasting neutralization of excess hydrochloric acid of gastric juice, thereby having a protective effect on the gastric mucosa. Achieving a positive effect within 3–5 minutes is due to the good solubility of the tablets and the high calcium content.

Pharmacokinetics

As a result of Rennie's interaction with gastric juice, soluble calcium and magnesium salts are formed in the stomach. The level of absorption of calcium and magnesium from these 2 compounds depends on the dose of the drug. The maximum absorption level is 10% calcium and 15-20% magnesium. A small amount of absorbed calcium and magnesium is excreted through the kidneys. If renal function is impaired, the concentration of calcium and magnesium in plasma may increase. In the intestines, insoluble compounds are formed from soluble salts, which are excreted in the feces.

Indications

Symptoms associated with increased acidity of gastric juice and reflux esophagitis: heartburn, sour belching, periodic pain in the stomach, a feeling of fullness or heaviness in the epigastric region, dyspepsia (including those caused by errors in diet, taking medications, alcohol abuse, coffee, nicotine), dyspepsia in pregnant women.

Contraindications

Severe renal failure, hypercalcemia, hypophosphatemia, nephrocalcinosis, hypersensitivity to the components of the drug, children under 12 years of age.

Use during pregnancy and breastfeeding

Directions for use and doses

Inside. Adults and children over 12 years of age: Unless otherwise directed by a doctor, chew 1-2 tablets (or keep in mouth until completely dissolved) when symptoms appear. If necessary, you can repeat the drug after 2 hours. The maximum daily dose is 11 tablets.

Side effects

If the recommended doses are followed, the drug is well tolerated, however, in very rare cases, allergic reactions are possible: rash, Quincke's edema, anaphylactic reactions. Long-term use of the drug in high doses in patients with impaired renal function can cause hypermagnesemia and hypercalcemia.

Overdose

Long-term use of the drug in high doses in patients with impaired renal function can cause hypermagnesemia, hypercalcemia, alkalosis, which can be manifested by nausea, vomiting, and muscle weakness. In this case, you should discontinue the drug and consult a doctor immediately.

Interaction with other drugs

Changes in the acidity of gastric juice during the use of antacids can lead to a decrease in the rate and extent of absorption of other drugs when taken simultaneously, so medications should be taken 1-2 hours before or after taking antacids. Tetracycline antibiotics, fluoroquinolones, cardiac glycosides, levothyroxine, iron preparations, fluorides, phosphates - when used simultaneously, antacids reduce the absorption of these drugs. Thiazide diuretics - when taken simultaneously with antacids, the concentration of calcium in the blood serum should be regularly monitored.

special instructions

When prescribing the drug to patients with impaired renal function, the concentration of magnesium, phosphorus and calcium in the blood serum should be regularly monitored. Patients with impaired renal function are not recommended to take the drug in high doses for a long time. Taking high doses of Rennie may increase the risk of kidney stones. Instructions for patients with diabetes: 1 tablet of Rennie contains 475 mg of sucrose. If the use of the drug is ineffective, you should consult a doctor for advice. Effect on the ability to drive a car and drive machinery. No effect.

Storage conditions

At a temperature not higher than 25 °C. Keep out of the reach of children.

Name:

Rennie

Pharmacological
action:

Rennie's drug is combination of two antacids: calcium carbonate and magnesium carbonate, which act locally by neutralizing stomach acid, which is independent of systemic absorption. Calcium carbonate exhibits long-lasting and strong neutralizing activity.
This effect is enhanced by magnesium carbonate, which also has powerful neutralizing activity.
The total neutralizing capacity of the drug in vitro is 16 mEq H+ (titrated to an endpoint of pH 2.5).
In healthy volunteers, the onset of neutralization is rapid.
Administration of 2 Rennie tablets on an empty stomach resulted in an increase in pH of more than 1 unit within 5 minutes and a significant increase in gastric pH above the baseline pH, which was achieved within 2 minutes.

In the stomach, calcium carbonate and magnesium carbonate react with gastric juice and form water and soluble mineral salts.
CaCO3+2HCl → CaCl2+H2O+CO2
MgCO3+2HCl → MgCl2+H2O+CO2
Calcium and magnesium can be absorbed in the form of their soluble salts.
The level of absorption of calcium and magnesium from these compounds depends on the dose of the drug.
Maximum absorption level- 10% calcium and 15–20% magnesium.
In healthy individuals, small amounts of absorbed calcium and magnesium are excreted by the kidneys.
If their function is impaired, the concentration of calcium and magnesium in the blood plasma may increase. In the intestines, insoluble compounds are formed from soluble salts, which are excreted in the feces.

Indications for
application:

The drug is taken for diseases of the gastrointestinal tract associated with increased acidity of gastric juice, including:
- gastritis with high and normal acidity, including chronic gastritis during exacerbation;
- acute duodenitis;
- stomach and duodenal ulcers during exacerbation; erosion of the mucous membrane of the gastrointestinal tract;
- gastralgia, sour belching;
- heartburn of various etiologies;
- the drug is also used for the symptomatic treatment of stomach pain resulting from poor diet, alcohol abuse, smoking and therapy with drugs that irritate the gastric mucosa.

Mode of application:

A drug for oral use in adults and children over 15 years of age.
The usual daily dose is 1-2 chewable tablets during periods of pain or heartburn; in case of pain, the dose can be increased for a short period to 5 tablets per day.
The duration of treatment should not exceed 10 days.

Side effects:

From the immune system: Very rarely, hypersensitivity reactions have been reported, manifesting as rash, urticaria, angioedema and anaphylaxis.
Metabolic and nutritional disorders: In patients, especially those with impaired renal function, long-term use in high doses can lead to hypermagnesemia (with the use of antacids containing magnesium) or hypercalcemia and alkalosis, which manifests itself in the form of gastric symptoms and muscle weakness.
From the gastrointestinal tract: Nausea, vomiting, stomach discomfort and diarrhea may occur.
From the musculoskeletal system and connective tissue: Possible muscle weakness.
Side effects detected only in milk-alkali syndrome(Burnett's syndrome):
- gastrointestinal disorders (ageusia);
- general disorders (calcinosis and asthenia);
- disorders of the nervous system (headache);
- disorders of the kidneys and urinary tract (azotemia).

Contraindications:

Hypersensitivity to the components of the drug;
- hypercalcemia and/or conditions that lead to hypercalcemia;
- nephrolithiasis caused by the deposition of stones containing calcium;
- severe renal failure (creatinine clearance<30 мл/мин);
- hypophosphatemia.

If symptoms persist, partially persist or their severity increases after 10 days of treatment, it is necessary to conduct an examination to find out their nature and reconsider the treatment regimen.
The course of treatment with Rennie should not exceed 10 days.
The drug should not be taken simultaneously with large amounts of milk or dairy products. Long-term use of the drug may increase the risk of kidney stones.
When using 4-5 tablets per day, the course of treatment should be short, treatment should be stopped immediately after the symptoms disappear.
It is recommended to consult a doctor if: weight loss, problems with swallowing or a constant feeling of discomfort in the abdomen, signs of digestive disorders if they appeared for the first time or changed their nature, kidney failure (calcium and magnesium levels must be monitored).
Calcium carbonate and magnesium carbonate should not be taken in case of hypercalciuria.
This drug should be used with caution in patients with impaired renal function.

If there is a need to use calcium carbonate and magnesium carbonate in this category of patients, the levels of calcium, phosphorus and magnesium in the blood plasma should be regularly checked.
Patients with hereditary diseases that are accompanied by fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltose deficiency should not be prescribed this drug, since it contains 475 mg of sucrose. This should also be taken into account by patients with diabetes.
1 sugar-free Rennie tablet contains 400 mg of sorbitol and saccharin, so the drug can be used in patients with diabetes, but it should be borne in mind that sorbitol may be harmful for patients with sorbitol intolerance.
The ability to influence reaction speed when driving vehicles or other mechanisms. Does not affect.
Children. Do not use in children under 15 years of age.

Interaction
other medicinal
by other means:

Other drugs are recommended to be used 1–2 hours before or after taking antacids.
In case of simultaneous use of Rennie with antibiotics (tetracyclines, quinolones) and cardiac glycosides (digoxin), phosphates, fluorine compounds and iron-containing products, levothyroxine sodium and eltrombopag there is a decrease in absorption of the latter.
Thiazide diuretics reduce urinary calcium excretion and increase its plasma level.
Due to the increased risk of hypercalcemia with concomitant use of thiazide diuretics, it is necessary to regularly monitor plasma calcium levels.
Also you should take a 2 hour break between using Rennie and the following drugs: antihistamines, atenolol, metoprolol or propanolol, chloroquine, diflunisal, digoxin, diphosphonates, fexofenadine, GCS (prednisolone and dexamethasone), indomethacin, ketoconazole, phenothiazide neuroleptics, penicillamine, thyroxine.

Pregnancy:

Until now, when calcium carbonate and magnesium carbonate were prescribed during pregnancy, there was no increase in the risk of fetal malformations.
Rennie can be prescribed during pregnancy, if you take the drug according to the instructions, but long-term use in high doses should be avoided.
It should also be taken into account that the presence of magnesium salts can cause diarrhea, and the presence of calcium in high doses, used for a long time, increases the risk of hypercalcemia with calcification of various organs, in particular the kidneys.
Should be considered that during pregnancy and lactation, calcium carbonate and magnesium carbonate provide significant amounts of calcium in addition to the amount that comes from food.
Therefore, pregnant women should limit the use of Rennie to 1 week and, while using the drug, avoid constant consumption of milk (1 liter contains up to 1.2 g of elemental calcium), as well as dairy products to prevent excess calcium, which can lead to the so-called milk-alkali syndrome (Burnett's syndrome), which is a rare but serious condition that requires medical attention.

Overdose:

Symptoms: Long-term use of calcium carbonate and magnesium carbonate in high doses, especially in patients with impaired renal function, can lead to renal failure, hypermagnesemia, hypercalcemia and alkalosis, which manifests itself in the form of gastrointestinal symptoms (nausea, vomiting, constipation) and muscle weakness . In case of overdose, diarrhea may also develop.
Treatment: in these cases, you should stop using the drug and ensure sufficient fluid intake into the body. In severe cases of overdose (for example, Burnett's syndrome), you should consult your doctor, as additional rehydration (infusions) may be required.

Release form:

Rennie tablets without sugar with mint flavor
Rennie tablets with menthol flavor 6 pieces in a blister, 2 or 4 blisters in a cardboard package.
Orange Flavored Rennie Tablets 6 pieces in a blister, 2 or 4 blisters in a cardboard package.

Storage conditions:

The drug should be stored out of the reach of children at a temperature not exceeding 25°C.
Best before date: for chewable tablets - 5 years, for chewable tablets (orange) and chewable tablets without sugar (mint) - 3 years.

1 chewable tablet (orange) Rennie contains:
- active ingredients: calcium carbonate - 680 mg, magnesium hydroxycarbonate - 80 mg;
- Excipients: sucrose - 475 mg, pregelatinized corn starch - 20 mg, potato starch - 13 mg, talc - 33.14 mg, magnesium stearate - 10.66 mg, liquid paraffin - 5 mg, orange flavor (orange oil, maltodextrin, purified water) - 35.2 mg , sodium saccharinate - 2 mg.

Before using RENNIE you should consult your doctor. These instructions for use are for informational purposes only. For more complete information, please refer to the manufacturer's instructions.

Clinical and pharmacological group

11.008 (Antacid drug)

Release form, composition and packaging

Chewable tablets are white with a creamy tint, square, with concave surfaces, engraved “Rennie” on both sides, with the smell of menthol.

Excipients: sucrose (475 mg), pregelatinized corn starch, potato starch, talc, magnesium stearate, light, menthol flavor, lemon flavor.

Chewable mint tablets without sugar are white with a creamy tint, square, with concave surfaces, engraved “Rennie” on both sides, with the smell of mint.

Excipients: sorbitol, pregelatinized corn starch, potato starch, talc, magnesium stearate, light liquid paraffin, mint flavor, sodium saccharinate.

6 pcs. - blisters (2) - cardboard packs. 6 pcs. - blisters (4) - cardboard packs. 6 pcs. - blisters (6) - cardboard packs. 6 pcs. - blisters (8) - cardboard packs. 6 pcs. - blisters (16) - cardboard packs. 12 pcs. - blisters (1) - cardboard packs. 12 pcs. - blisters (2) - cardboard packs. 12 pcs. - blisters (3) - cardboard packs. 12 pcs. - blisters (4) - cardboard packs. 12 pcs. - blisters (8) - cardboard packs.

Read also:

Chewable tablets (orange) are white with a creamy tint, square, with concave surfaces, engraved “Rennie” on both sides, with the smell of orange.

Excipients: sucrose (475 mg), pregelatinized corn starch, potato starch, talc, magnesium stearate, liquid paraffin, orange flavor (orange oil, maltodextrin, purified water), sodium saccharinate.

6 pcs. - blisters (2) - cardboard packs. 6 pcs. - blisters (4) - cardboard packs. 6 pcs. - blisters (6) - cardboard packs. 6 pcs. - blisters (8) - cardboard packs. 6 pcs. - blisters (16) - cardboard packs. 12 pcs. - blisters (1) - cardboard packs. 12 pcs. - blisters (2) - cardboard packs. 12 pcs. - blisters (3) - cardboard packs. 12 pcs. - blisters (4) - cardboard packs. 12 pcs. - blisters (8) - cardboard packs.

pharmachologic effect

Local antacid drug. Contains calcium carbonate and magnesium carbonate, which provide rapid and long-lasting neutralization of excess hydrochloric acid in gastric juice, thereby providing a protective effect on the gastric mucosa.

Achieving a therapeutic effect within 3-5 minutes is due to the good solubility of the tablets and high calcium content.

Pharmacokinetics

Suction

As a result of the interaction of Rennie® with gastric juice, soluble calcium and magnesium salts are formed in the stomach. The level of absorption of calcium and magnesium from these compounds depends on the dose of the drug. The maximum absorption level is 10% calcium and 15-20% magnesium.

Removal

A small amount of absorbed calcium and magnesium is excreted by the kidneys. In the intestines, insoluble compounds are formed from soluble salts, which are excreted in the feces.

Pharmacokinetics in special clinical situations

If renal function is impaired, plasma calcium and magnesium concentrations may increase.

RENNIE: DOSAGE

For adults and children over 12 years of age, when symptoms appear, 1-2 tablets. should be chewed (or kept in the mouth until completely absorbed). If necessary, you can repeat taking the drug after 2 hours. The maximum daily dose is 16 tablets.

Drug interactions

Medicines should be taken 1-2 hours before or after taking antacids.

With simultaneous use, Rennie® reduces the absorption of tetracycline antibiotics, fluoroquinolones, and phosphates.

Anticholinergic drugs enhance and prolong the effect of Rennie®, slowing gastric emptying.

With simultaneous use, Rennie® enhances the effect of levodopa, acetylsalicylic acid and nalidixic acid.

Pregnancy and lactation

RENNIE: SIDE EFFECTS

Allergic reactions: in very rare cases, rash, angioedema, and anaphylactic reactions are possible.

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. The shelf life of chewable tablets with mint flavor is 5 years, chewable tablets with orange flavor are 3 years.

Indications

Symptoms associated with increased acidity of gastric juice and reflux esophagitis (including those caused by errors in diet, taking medications, abuse of alcohol, coffee, nicotine):

• heartburn;
• belching;
• periodic pain in the stomach;
• feeling of fullness or heaviness in the epigastric region;
• flatulence;
• dyspepsia.

Dyspepsia in pregnant women.

Contraindications

• severe renal failure;
• hypercalcemia;
• hypersensitivity to the components of the drug.

special instructions

If it is necessary to prescribe the drug to patients with diabetes, it should be kept in mind that 1 Rennie® tablet with menthol flavor and 1 Rennie® tablet with orange flavor contain 475 mg of sucrose.

1 tablet of Rennie® with mint flavor contains 400 mg of sorbitol and saccharin and can be prescribed to patients with diabetes.

If treatment is ineffective, the patient should consult a doctor.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive vehicles and other activities that require high concentration and speed of psychomotor reactions.

Use for renal impairment

The drug is contraindicated in severe renal failure.

When prescribing the drug to patients with impaired renal function, the concentration of magnesium and calcium in the blood serum should be regularly monitored.

Taking Rennie® in high doses may increase the risk of kidney stones.

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.

Registration numbers

tab. chewable 680 mg+80 mg: 12, 24, 36, 48 or 96 pcs. P N012507/01 (2003-08-10 – 0000-00-00) tab. chewing mints without sugar 680 mg+80 mg: 12, 24, 36, 48 or 96 pcs. P N012507/02 (2003-08-10 – 2003-08-15) tab. chewable (orange) 680 mg+80 mg: 12, 24, 36, 48 or 96 pcs. LSR-005201/08 (2003-07-08 – 0000-00-00)

Rennie is a medication that effectively eliminates all the unpleasant symptoms of heartburn. It is a gastroprotector that also has an antacid effect.

The mechanism of action of this medication is based on the unique properties of the substances in its composition. When tablets interact with human gastric juice, a specific chemical reaction occurs, resulting in the neutralization of hydrochloric acid, increasing the natural protection of stomach cells and mucus formation. Rennie quickly eliminates stomach discomfort caused by increased hydrochloric acid levels.

Composition and pharmacological action

The main components of the medicine are magnesium and calcium carbonate, and auxiliary components are corn and potato starch, talc, flavorings, magnesium stearate and others.

The pharmacological action of this medication is based on the interaction of its active substances with hydrochloric acid. As a result of this reaction, the acid is neutralized and water with water-soluble magnesium and calcium salts is formed. Magnesium carbonate helps increase the formation of mucus, as well as protecting the cells of the gastrointestinal tract from the negative effects of hydrochloric acid. Taking Rennie is accompanied by the elimination of other symptoms of gastric dyspepsia: feelings of fullness and nausea, sour belching and flatulence.

What are Rennie tablets prescribed for?

• heartburn;
• stomach pain;
• gastritis;
• ulcerative lesions of the stomach or duodenum;
• gastralgia;
• belching sour;
• duodenitis.

This medicine can be taken by adults and children whose age has exceeded 12 years. Recommended single dosage is 1 - 2 tablets, which must be chewed or dissolved in the mouth. If 1-2 hours after using Rennie you do not notice a positive effect, you are allowed to take it again. The maximum permissible daily dose is 16 tablets. The duration of treatment depends on the symptoms bothering the patient.

It is important to remember that this medication, like any other medicine, has contraindications for use. Doctors advise against treatment with this drug if you are susceptible to the following pathologies:

• hypercalcemia – a condition characterized by an increase in the concentration of calcium in the blood plasma;
• hypophosphatemia – a decrease in the level of phosphates in the blood;
• nephrolithiasis - a pathology associated with the formation of stones in the renal pelvis and calyces;
• severe renal failure.

You should also not use Rennie if you are hypersensitive to one or more of its components.

Interaction with other medications

The combined effect of this drug with other drugs may interfere with the concentration of other substances in the blood plasma and also affect the rate of their absorption. If you need to take several medications at the same time, set a certain time interval between the times of taking them (1 - 2 hours).

Shelf life and storage conditions

Tablets should be stored in a dry place, the temperature in which does not exceed 25°C. Shelf life – five years.