What is the anterior mediastinum? Mediastinal tumors are formations of different morphological nature. Boundaries and main organs

Mediastinum I Mediastinum

part of the chest cavity, bounded in front by the sternum and behind by the spine. Covered with intrathoracic fascia, on the sides - with mediastinal pleura. From above, the border of S. is the upper aperture of the chest, from below -. The mediastinum contains the pericardium, large vessels, the trachea and main vessels, the esophagus, and the thoracic duct ( rice. 12 ).

The mediastinum is conventionally divided (along the plane passing through the trachea and main bronchi) into anterior and posterior. In the anterior are the Thymus, the right and left brachiocephalic and superior vena cava, the ascending part and (Aorta), its branches, the Heart and the Pericardium, in the posterior are the thoracic part of the aorta, the esophagus, the vagus nerves and sympathetic trunks, their branches, unpaired and semi-unpaired veins, Thoracic duct. In the anterior S. there are upper and lower sections (the lower one contains the heart). The loose tissue surrounding the organs communicates at the top through the anterior S. with the previsceral cellular tissue space of the neck, through the posterior - with the retrovisceral cellular tissue space of the neck, at the bottom through the holes in the diaphragm (along the para-aortic and peri-esophageal cellular tissue) - with the retroperitoneal cellular tissue. Between the fascial sheaths of organs and vessels of the S., interfascial gaps and spaces are formed, filled with fiber, forming fiber spaces: pretracheal - between the trachea and the aortic arch, in which the posterior thoracic aortic plexus is located; retrotracheal - between the trachea and the esophagus, where the paraesophageal and posterior mediastinal lie; left tracheobronchial, where the aortic arch, left vagus and left upper tracheobronchial lymph nodes are located; right tracheobronchial, which contains the azygos, right vagus nerve, right upper tracheobronchial lymph nodes. Between the right and left main bronchi there is an interbronchial, or bifurcation, space with the lower tracheobronchial lymph nodes located in it.

Blood supply is provided by the branches of the aorta (mediastinal, bronchial, esophageal, pericardial); The outflow of blood occurs into the azygos and semi-amygos veins. Lymphatic vessels conduct lymph to the tracheobronchial (upper and lower), peritracheal, posterior and anterior mediastinal, prepericardial, lateral pericardial, prevertebral, intercostal, perithoracic lymph nodes. S. is carried out by the thoracic aortic nerve plexus.

Research methods. In most cases, S.’s pathology can be identified based on the results of a clinical examination and standard fluorography (Fluorography), as well as using radiography (X-ray) of the chest. In case of swallowing disorders, it is advisable to perform X-ray contrast and endoscopic examination of the esophagus. Angiography (angiography) is sometimes used to visualize the superior and inferior vena cava, aorta, and pulmonary trunk. Computed X-ray tomography and nuclear magnetic resonance imaging have great potential, which are the most informative methods for diagnosing mediastinal diseases. If a pathology of the thyroid gland (retrosternal) is suspected, a radionuclide scan is indicated. For morphological verification of the diagnosis, mainly for S. tumors, endoscopic methods are used (bronchoscopy (Bronchoscopy) with transtracheal or transbronchial puncture, thoracoscopy, mediastinoscopy), transthoracic puncture, mediastinotomy. During mediastinoscopy, the anterior S. is examined using a mediastinoscope inserted after mediastinotomy. is a surgical operation that can be used for diagnostic purposes.

Developmental defects. Among the malformations of S., the most common are pericardial cysts (coelomic), dermoid cysts, bronchogenic cysts, and enterogenic cysts. Pericardial cysts are usually thin-walled and filled with clear fluid. As a rule, they are asymptomatic and are an incidental finding during X-ray examination. Bronchogenic cysts are localized near the trachea and large bronchi and can cause respiratory tract problems, resulting in dryness, shortness of breath, and stridor. Enterogenous cysts are localized near the esophagus and can ulcerate with subsequent perforation and the formation of fistulas with the esophagus, trachea, and bronchi. developmental defects S. operational. favorable with timely treatment.

Damage. There are closed and open injuries to the S. Closed injuries to the S. occur with bruises and compression of the chest, fractures of the sternum, or general contusions and are characterized by the formation of a hematoma in the tissue of the S. Clinically, they are manifested by moderate chest pain, shortness of breath, mild cyanosis, and slight swelling of the neck veins. from small vessels stops spontaneously. Bleeding from larger vessels is accompanied by the formation of an extensive hematoma and the spread of blood through the tissue C. When the vagus nerves are imbibited by blood, a syndrome sometimes occurs, characterized by severe respiratory impairment, circulatory disorders, and the development of bilateral pneumonia. S. hematomas lead to mediastinitis or mediastinal abscess. Closed S. injuries due to trauma to hollow organs are often complicated by Pneumothorax and Hemothorax. If the trachea or large bronchi, less often the lungs and esophagus, are damaged in S., mediastinal or pneumomediasticum penetrates and develops. A small amount of air is localized within the S., and when it enters in significant quantities, the air can spread through the cellular spaces beyond the S. In this case, extensive subcutaneous emphysema develops and unilateral or bilateral emphysema is possible. Widespread mediastinal emphysema is accompanied by pressing chest pain, shortness of breath and cyanosis. The patient's general condition sharply worsens, often observed in the subcutaneous tissue of the face, neck and upper half of the chest, disappearance of cardiac dullness, weakening of heart sounds. confirms the accumulation of gas in the tissue of the S. and neck.

Open injuries to the chest are often associated with injuries to other organs of the chest. Injuries to the thoracic trachea and main bronchi simultaneously with the great vessels (aortic arch, superior vena cava, etc.) usually lead to death at the scene. If he remains alive, then respiratory distress, coughing attacks with the release of foamy blood, mediastinal emphysema, and pneumothorax occur. A sign of injury to the trachea and large bronchi may be air escaping through the wound when exhaling. Penetration of the chest from the front and left side should raise suspicion for a possible heart attack (Heart). The thoracic esophagus is rarely isolated, is accompanied by mediastinal emphysema, and purulent Mediastinitis and Pleurisy quickly develop. thoracic duct (thoracic duct) are more often detected several days or even weeks later and are characterized by increasing effusion pleurisy. Pleural fluid (chyle), in the absence of blood, resembles milk in color and, in a biochemical study, contains an increased amount of triglycerides.

The scope of first aid for wounds of S.'s organs is usually small, the application of aseptic, toilet of the upper respiratory tract, according to indications - the administration of painkillers and oxygen.

When performing emergency medical measures for open wounds of S.'s organs, it is necessary to adhere to the following sequence: toilet of the respiratory tract, sealing of the chest cavity and trachea, pleural cavity, subclavian or jugular vein.

Sealing the chest cavity is mandatory in cases of open pneumothorax. Temporary sealing is achieved by applying a bandage with a sterile cotton-gauze pad that completely covers the wound opening. Oilcloth, cellophane, polyethylene or other impenetrable material is placed on top. The bandage is fixed far beyond the edges with a tiled application of strips of adhesive plaster. It is advisable to bandage the arm to the affected side of the chest. For small incised wounds, you can compare their edges and fix them with an adhesive plaster.

In case of breathing problems, an “Ambu” type bag or any portable breathing apparatus is used for artificial ventilation of the lungs (Artificial lung). You can start mechanical ventilation with mouth-to-mouth or mouth-to-mouth breathing, and then perform tracheal intubation (see Intubation).

Pleural puncture is necessary if there are signs of internal tension pneumothorax. It is performed in the second intercostal space in front with a thick needle with a wide lumen or trocar to ensure free air from the pleural cavity. The needle is either temporarily connected to a plastic or rubber tube with a valve at the end.

In case of the rarely observed rapid development of tense mediastinal emphysema, emergency cervical surgery is indicated - the skin above the jugular notch with the creation of a duct behind the sternal tissue into tissue C.

All victims and wounded are hospitalized in specialized surgical departments. Transportation should be carried out by a specialized resuscitation machine. It is preferable to transport the victim in a semi-sitting position. The accompanying document indicates the circumstances of the injury, its clinical symptoms and a list of treatment measures taken.

In the hospital, after examination and the necessary examination, the issue of further treatment tactics is decided. If the condition of a patient with a closed S. injury improves, they are limited to rest, symptomatic therapy, and the prescription of antibiotics to prevent infectious complications.

The scope of surgical interventions for open injuries of the chest is quite wide - treatment of chest wounds to complex operations on the organs of the chest cavity. Indications for urgent thoracotomy are injuries to the heart and large vessels, trachea, large bronchi and lungs with bleeding, tension pneumothorax, injuries to the esophagus, diaphragm, progressive deterioration of the patient’s condition in case of an unclear diagnosis. When deciding on surgery, it is necessary to take into account the damage, the degree of functional impairment and the effect of conservative measures.

Diseases. Inflammatory diseases of S. - see Mediastinitis. Relatively often a retrosternal goiter is detected. There is a “diving” retrosternal goiter, most of which is located in the S., and the smaller part is on the neck (protrudes when swallowing); the retrosternal goiter itself, localized entirely behind the sternum (its upper pole is palpable behind the notch of the manubrium of the sternum); intrathoracic, located deep in the S. and inaccessible for palpation. “Diving” goiter is characterized by periodically occurring asphyxia, as well as symptoms of compression of the esophagus (). With retrosternal and intrathoracic goiter, symptoms of compression of large vessels, especially veins, are noted. In these cases, swelling of the face and neck, swelling of the veins, hemorrhages in the sclera, dilation of the veins of the neck and chest are detected. in these patients it is increased, headaches, weakness, and shortness of breath are observed. To confirm the diagnosis, radionuclide with 131 I is used, but the negative results of this study do not exclude the presence of a so-called cold colloidal node. The retrosternal and intrathoracic goiter can become malignant, so its early radical removal is necessary.

Tumors S. are observed equally often in men and women; occur predominantly in young and mature adults. Most of them are congenital neoplasms. Benign tumors of S. significantly prevail over malignant ones.

The clinical symptoms of benign neoplasms of S. depend on many factors - the growth rate and size of the tumor, its location, the degree of compression of adjacent anatomical formations, etc. During the course of neoplasms of S., two periods are distinguished - an asymptomatic period with clinical manifestations. Benign tumors develop asymptomatically for a long time, sometimes years and even decades.

There are two main syndromes in S.'s pathology - compression and neuroendocrine. Compression syndrome is caused by a significant increase in pathological formation. It is characterized by a feeling of fullness and pressure, dull pain behind the sternum, shortness of breath, cyanosis of the face, swelling of the neck, face, dilatation of the saphenous veins. Then signs of dysfunction of certain organs appear as a result of their compression.

There are three types of compression symptoms: organ (compression of the heart, trachea, main bronchi, esophagus), vascular (compression of the brachiocephalic and superior vena cava, thoracic duct, displacement of the aorta) and neurogenic (compression with impaired conductivity of the vagus, phrenic and intercostal nerves, sympathetic trunk).

Neuroendocrine syndrome is manifested by damage to joints, reminiscent of large and tubular bones. Various changes in heart rate and angina are observed.

Neurogenic tumors of the S. (neurinomas, neurofibromas, ganglioneuromas) often develop from the sympathetic trunk and intercostal nerves and are located in the posterior S. With neurogenic tumors, the symptoms are more pronounced than with all other benign formations of the S. Pain in the sternum, in the back, and headaches are noted , in some cases - sensitive, secretory, vasomotor, pilomotor and trophic disorders on the skin of the chest from the side of the tumor. Less commonly observed are Bernard-Horner syndrome, signs of compression of the recurrent laryngeal nerve, etc. Radiologically, neurogenic tumors are characterized by a homogeneous, intense oval or round shadow, closely adjacent to the spine.

Ganglioneuromas may have an hourglass shape if part of the tumor is located in the spinal canal and is connected by a narrow stalk to the tumor in the mediastinum. In such cases, signs of spinal cord compression, even paralysis, are combined with mediastinal symptoms.

Of the tumors of mesenchymal origin, lipomas are the most common, fibromas, hemangiomas, lymphangiomas are less common, and chondromas, osteomas and hibernomas are even less common.

Metastatic damage to S.'s lymph nodes is typical for lung and esophageal cancer, thyroid and breast cancer, seminoma and adenocarcinoma.

In order to clarify the diagnosis, the entire necessary set of diagnostic measures is used, however, the final determination of the type of malignant tumor is possible only after a biopsy of a peripheral lymph node, examination of pleural exudate, tumor puncture obtained by puncture through the chest wall or tracheal wall, bronchus or bronchoscopy, mediastinoscopy or parasternal mediastinotomy , thoracotomy as the final stage of diagnosis. Radionuclide research is carried out to determine the shape of the size, the extent of the tumor process, as well as the differential diagnosis of malignant and benign tumors, cysts and inflammatory processes.

In case of malignant tumors, the risk of surgery is determined by many factors, and primarily by the prevalence and morphological features of the process. Even partial removal of S.'s malignant tumor improves the condition of many patients. In addition, a decrease in tumor mass creates favorable conditions for subsequent radiation and chemotherapy.

Contraindications to surgery are the serious condition of the patient (extreme, severe hepatic, renal, pulmonary-heart failure, not amenable to therapeutic intervention) or signs of obvious inoperability (the presence of distant metastases, a malignant tumor in the parietal pleura, etc.).

The prognosis depends on the shape of the tumor and the timeliness of treatment.

Bibliography: Blokin N.N. and Perevodchikova N.I. tumor diseases, M., 1984; Vagner E.A. breast injuries, M, 1981; Wagner E. A et al. bronchi, Perm, 1985; Vishnevsky A.A. and Adamyak A.A. Surgery of the mediastinum, M, 1977, bibliogr.; Elizarovsky S.I. and Kondratyev G.I. Surgical mediastinum, M., 1961, bibliogr.; Isakov Yu.F. and Stepanov E.A. and cysts of the thoracic cavity in children, M., 1975; Petrovsky B.V., Perelman M.I. and Koroleva N.S. Tracheobronchialnaya, M., 1978.

Rice. 1. Mediastinum (right view, mediastinal pleura, part of the costal and diaphragmatic pleura are removed, tissue and lymph nodes are partially removed): 1 - trunks of the brachial plexus (cut off); 2 - left subclavian artery and vein (cut off); 3 - superior vena cava; 4 - II rib; 5 - right phrenic nerve, pericardial diaphragmatic artery and vein; 6 - right pulmonary artery (cut off); 7 - pericardium; 8 - diaphragm; 9 - costal pleura (cut off); 10 - great splanchnic nerve; 11 - right pulmonary veins (cut off); 12 - posterior intercostal artery and vein; 13 - lymphatic; 14 - right bronchus; 15 - azygos vein; 16 - esophagus; 17 - right sympathetic trunk; 18 - right vagus nerve; 19 - trachea.

Rice. 2. Mediastinum (left view, mediastinal pleura, part of the costal and diaphragmatic pleura, as well as fiber have been removed): 1 - clavicle; 2 - left sympathetic trunk; 3 - esophagus; 4 - thoracic duct; 5 - left subclavian artery; 6 - left vagus nerve; 7 - thoracic aorta; 8 - lymph node; 9 - great splanchnic nerve; 10 - hemizygos vein; 11 - diaphragm; 12 - esophagus; 13 - left phrenic nerve, pericardial diaphragmatic artery and vein; 14 - pulmonary veins (cut off); 15 - left pulmonary artery (cut off); 16 - left common carotid artery; 17 - left brachiocephalic vein.

II Mediastinum (mediastinum, PNA, JNA; septum mediastinale,)

part of the thoracic cavity located between the right and left pleural sacs, bounded in front by the sternum, behind by the thoracic spine, below by the diaphragm, above by the superior aperture of the chest.

Superior mediastinum(m. superius, PNA; cavum mediastinale superius, BNA; pars cranialis mediastini, JNA) - part of the S. located above the roots of the lungs; contains the thymus gland or its adipose tissue, the ascending aorta and the aortic arch with its branches, the brachiocephalic and superior vena cava, the terminal portion of the azygos vein, lymphatic vessels and nodes, the trachea and the beginning of the main bronchi, the phrenic and vagus nerves.

Posterior mediastinum -

1) (m. posterius, PNA) - part of the lower S., located between the posterior surface of the pericardium and the spine; contains the lower esophagus, descending aorta, azygos and semi-gypsy veins, thoracic duct, lymph nodes, nerve plexuses, vagus nerves and sympathetic trunks;

2) (cavum mediastinale posterius, BNA; pars dorsalis mediastini, JNA) - part of the S., located posterior to the roots of the lungs; contains the esophagus, aorta, azygos and semi-gypsy veins, thoracic duct, lymph nodes, nerve plexuses, vagus nerves and sympathetic trunk.

Mediastinum inferior(m. inferius, PNA) - part of the S., located below the roots of the lungs; divided into anterior, middle and posterior C.

Anterior mediastinum -

1) (m. anterius, PNA) - part of the lower S., located between the posterior surface of the anterior chest wall and the anterior surface of the pericardium; contains internal mammary arteries and veins, parathoracic lymph nodes;

2) (cavum mediastinale anterius, BNA; pars ventralis mediastini, JNA) - part of the S., located anterior to the roots of the lungs; contains the thymus gland, heart with pericardium, aortic arch and superior vena cava with their branches and tributaries, trachea and bronchi, lymph nodes, nerve plexuses, phrenic nerves.

- in anatomy, part of the thoracic cavity in mammals and humans, in which the heart, trachea and esophagus are located. In humans, the mediastinum is limited laterally by the pleural sacs (they contain the lungs), below by the diaphragm, in front by the sternum and behind... ... Big Encyclopedic Dictionary

MEDIASTINUM, mediastinum, plural. no, cf. 1. The space between the spine and the sternum, in which the heart, aorta, bronchi and other organs are located (anat.). 2. transfer A barrier, an obstacle that prevents communication between two parties (book). “...Abolish... ... Ushakov's Explanatory Dictionary

MEDIASTINUM- MEDIASTINUM, mediastinum (from Latin in me dio stans standing in the middle), the space located between the right and left pleural cavities and limited laterally by the pleura mediastinalis, dorsally by the thoracic spine by the ischs of the ribs... Great Medical Encyclopedia

Mediastinum- (anatomical), part of the chest cavity in mammals and humans, in which the heart, trachea and esophagus are located. In humans, the mediastinum is limited on the sides by the pleural sacs (they contain the lungs), below by the diaphragm, in front by the sternum, behind... ... Illustrated Encyclopedic Dictionary

MEDIA, I, cf. (specialist.). The place in the middle part of the chest cavity where the heart, trachea, esophagus, and nerve trunks are located. | adj. mediastinal, oh, oh. Ozhegov's explanatory dictionary. S.I. Ozhegov, N.Yu. Shvedova. 1949 1992 … Ozhegov's Explanatory Dictionary

- (mediastinum), the middle part of the thoracic cavity of mammals, which contains the heart with large vessels, trachea and esophagus. Bounded anteriorly by the sternum, posteriorly by the thoracic spine, laterally by the pleura, and inferiorly by the diaphragm; top, considered the border... Biological encyclopedic dictionary Publisher: Publishing Solutions, eBook(fb2, fb3, epub, mobi, pdf, html, pdb, lit, doc, rtf, txt)


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Meaning of the word mediastinum

mediastinum in the crossword dictionary

Dictionary of medical terms

mediastinum (mediastinum, PNA, JNA; septum mediastinale, BNA)

part of the thoracic cavity located between the right and left pleural sacs, bounded in front by the sternum, behind by the thoracic spine, below by the diaphragm, above by the superior aperture of the chest.

Explanatory dictionary of the Russian language. D.N. Ushakov

mediastinum

mediastinum, plural no, cf.

    The space between the spine and the sternum, in which the heart, aorta, bronchi and other organs are located (anat.).

    trans. A barrier, an obstacle that prevents communication between two parties (book). :Abolish the districts, which are turning into an unnecessary mediastinum between the region and the districts: Stalin (report of the Central Committee at the XVI Congress of the All-Union Communist Party (Bolsheviks), 1930).

Explanatory dictionary of the Russian language. S.I.Ozhegov, N.Yu.Shvedova.

mediastinum

I, Wed. (specialist.). The place in the middle part of the chest cavity where the heart, trachea, esophagus, and nerve trunks are located.

adj. mediastinal, -aya, -oe.

Encyclopedic Dictionary, 1998

mediastinum

in anatomy - part of the thoracic cavity in mammals and humans, in which the heart, trachea and esophagus are located. In humans, the mediastinum is bounded laterally by the pleural sacs (they contain the lungs), below by the diaphragm, in front by the sternum and behind by the spine.

Mediastinum

anatomical region in the human chest cavity, limited in front by the sternum, behind by the thoracic spine, on the sides by the pleura and surfaces of the lungs, below by the diaphragm (see Thoracic obstruction); The upper limit is considered to be a conventional horizontal line passing along the upper edge of the sternum. There are anterior and posterior lungs, separated by the roots of the lungs. The anterior S. contains the heart with the pericardial sac (pericardium), the ascending part of the aorta and its arch with the arterial vessels extending from them, the pulmonary trunk, the superior and inferior vena cava, the pulmonary veins, and the phrenic nerves. In the posterior S. there are the thoracic part of the descending aorta and its branches, the esophagus, the azygos and semi-gypsy veins, the thoracic lymphatic duct, and the vagus and celiac nerves. Closed injuries to S.'s organs occur due to bruises, chest compressions, and sternum fractures. When the lungs or bronchi are damaged and air accumulates, emphysema of the lungs and compression of its organs develop. Open injuries to the lungs are combined with damage to the lungs and often to the abdominal organs. The treatment of these injuries is surgical. Among S.'s diseases, the most common are mediastinitis, retrosternal location of an enlarged thyroid gland, cysts and tumors of S.'s organs, and damage to the S.'s lymph nodes, for example, with lymphogranulomatosis.

Lit.: Petrovsky B.V., Surgery of the mediastinum, M., 1960; Elizarovsky S.I., Kondratyev G.I., Atlas “Surgical anatomy of the mediastinum”, M., 1961; Golbert Z. V., Lavnikova G. A., Tumors and cysts of the mediastinum, M., 1965.

Wikipedia

Mediastinum

Mediastinum- anatomical space in the middle parts of the chest cavity. The mediastinum is limited by the sternum and spine. The mediastinal organs are surrounded by fatty tissue. The pleural cavities are located on the sides of the mediastinum.

Examples of the use of the word mediastinum in the literature.

When examining the chest organs, they are clearly visible mediastinum, great vessels, heart, as well as lungs and lymph nodes.

And it is clear that in these variants and details one can encounter more and more genuine aberrations than in its seed, for the perception of which by the Indian people teleological forces worked for many centuries, spending incredible work on weakening many of its representatives mediastinum between daytime consciousness and deep memory - a repository of memories of the paths of the soul until the moment of its last incarnation.

The cause is an inflammatory process, accumulation of mucus, pus, blood in the respiratory tract, compression of the bronchi by enlarged lymph nodes, displacement of organs mediastinum.

Fiber inflammation mediastinum, is most often caused by a purulent nonspecific infection.

It is most often located in the subcutaneous fatty tissue, in the area of ​​the shoulder blades, on the shoulders, limbs, in the retroperitoneal space, mediastinum and etc.

The air accumulated in the pleural cavity compresses the lung and displaces mediastinum in a healthy direction.

The danger of open pneumothorax is that when breathing, air enters and leaves the pleura, which infects the pleura and leads to balloting mediastinum, irritation of nerve endings and a decrease in the respiratory surface of the lungs.

The contrast between the murder and the blue sky made me feel cruel mediastinum between these two shores, where all principles, images, emotions and premonitions flowed like a chaotic waterfall, knowing no barriers.

The sparkling robot, visibly embodying the countless wealth of its owner, pulled back the silk cover, revealing to all eyes a mirror-polished golden figurine of a naked young man, who was plunging a double-edged sword into the very mediastinum defeated word mill.

Spread of phlegmon of the neck to the anterior and posterior mediastinum often leads to death.

So adults in the war were accustomed to it through everyday life, but for Ivan this mediastinum did not have.

The professor, with a serious look, as if he was doing something very important, determined the limits of his stupidity, the degree of displacement mediastinum etc.

Everyday life, everyday life, everyday life could be like this mediastinum, adaptation of the body to the merciless climate of war.

The flow of ion gas covered them with a dense curtain inside a gravitational oasis in the very mediastinum cluster - a safe haven in which they intended to rest before returning to Coruscant.

The little thymus, the tiny gland of my unborn son, the all-powerful ruler of the immune system, tirelessly destroyed the tumor in my mediastinum, suffocated and crushed the tumor in the lung, drove the cancer away from me.

Mediastinal tumor is a relatively rare pathology. According to statistics, formations in this area occur in no more than 6-7% of all human tumors. Most of them are benign, only a fifth are initially malignant.

Among patients with mediastinal tumors, there are approximately the same number of men and women, and the predominant age of patients is 20-40 years, that is, the most active and young part of the population suffers.

From a morphological point of view, tumors of the mediastinal region are extremely heterogeneous, but almost all of them, even benign in nature, are potentially dangerous due to possible compression of surrounding organs. In addition, the peculiarity of their localization makes them difficult to remove, which is why they seem to be one of the most difficult problems in thoracic surgery.

Most people who are far from medicine have a very vague idea of ​​what the mediastinum is and what organs are located there. In addition to the heart, the structures of the respiratory system, large vascular trunks and nerves, and the lymphatic apparatus of the chest, which can give rise to all sorts of formations, are concentrated in this area.

The mediastinum (mediastinum) is a space, the anterior part of which is formed by the sternum, the anterior sections of the ribs, covered from the inside by the retrosternal fascia. The posterior mediastinal wall is the anterior surface of the spinal column, the prevertebral fascia and the posterior segments of the ribs. The lateral walls are represented by layers of the pleura, and from below the mediastinal space is closed by the diaphragm. The upper part does not have a clear anatomical boundary; it is an imaginary plane running through the upper end of the sternum.

Within the mediastinum are the thymus, the upper segment of the superior vena cava, the aortic arch and arterial vascular lines originating from it, the thoracic lymphatic duct, nerve fibers, fiber, the esophagus passes behind, the heart in the pericardial sac is located in the middle zone, the zone of division of the trachea into bronchi, pulmonary vessels.

The mediastinum is divided into upper, middle and lower floors, as well as anterior, middle and posterior parts. To analyze the extent of tumor spread, the mediastinum is conventionally divided into upper and lower halves, the border between which is the upper part of the pericardium.

The posterior mediastinum is characterized by the growth of neoplasia from lymphoid tissue (), neurogenic tumors, and metastatic cancers of other organs. In the anterior mediastinal region, lymphoma and teratoid tumors, mesenchymomas from connective tissue components are formed, and the risk of malignancy of neoplasia of the anterior mediastinum is higher than in other parts. In the middle mediastinum, lymphomas, cystic cavities of bronchogenic and dysembryogenetic origin, and other cancers are formed.

Tumors of the upper mediastinum are thymomas, lymphomas and intrathoracic goiter, as well as. In the middle floor, thymomas and bronchogenic cysts are found, and in the lower mediastinal region, pericardial cysts and fatty tumors are found.

Classification of mediastinal neoplasia

The tissues of the mediastinum are extremely diverse, so tumors in this area are united only by a common location, otherwise they are diverse and have different sources of development.

Tumors of the mediastinal organs can be primary, that is, initially growing from the tissues of this area of ​​the body, as well as secondary - metastatic nodes of cancer of another localization.

Primary mediastinal neoplasias are distinguished by histogenesis, that is, the tissue that became the ancestor of the pathology:

  • Neurogenic - ganglioneuroma - grow from peripheral nerves and nerve ganglia;
  • Mesenchymal - fibroma, etc.;
  • Lymphoproliferative - Hodgkin's disease, lymphoma, lymphosarcoma;
  • Dysontogenetic (formed due to a violation of embryonic development) - teratomas, chorionepithelioma;
  • - neoplasia of the thymus gland.

Mediastinal neoplasms are mature and immature, while mediastinal cancer is not an entirely correct formulation, given the sources of its origin. Epithelial neoplasia is called cancer, and connective tissue formations and teratomas are found in the mediastinum. Cancer in the mediastinum is possible, but it will be secondary, that is, it will arise as a result of metastasis of carcinoma of another organ.

Thymomas- These are tumors of the thymus gland that affect people 30-40 years old. They make up approximately one fifth of all mediastinal tumors. There are malignant thymoma with a high degree of invasion (sprouting) of surrounding structures, and benign. Both varieties are diagnosed with approximately equal frequency.

Dysembryonic neoplasia- also not uncommon in the mediastinum; up to a third of all teratomas are malignant. They are formed from embryonic cells that have remained here since intrauterine development, and contain components of epidermal and connective tissue origin. Usually the pathology is detected in adolescents. Immature teratomas grow actively and metastasize to the lungs and nearby lymph nodes.

Favorite location of tumors neurogenic origin- nerves of the posterior mediastinum. Carriers can be the vagus and intercostal nerves, spinal membranes, and sympathetic plexus. They usually grow without causing any concern, but the spread of neoplasia into the spinal cord canal can cause compression of the nervous tissue and neurological symptoms.

Tumors of mesenchymal origin- the widest group of neoplasms, diverse in structure and source. They can develop in all parts of the mediastinum, but more often in the anterior part. Lipomas are benign tumors of adipose tissue, usually unilateral, can spread up or down the mediastinum, penetrating from the anterior to the posterior part.

Lipomas They have a soft consistency, which is why symptoms of compression of adjacent tissues do not occur, and pathology is discovered by chance during examination of the chest organs. Its malignant counterpart, liposarcoma, is extremely rarely diagnosed in the mediastinum.

Fibroids are formed from fibrous connective tissue, grow asymptomatically for a long time, and call the clinic when they reach large sizes. They can be multiple, of different shapes and sizes, and have a connective tissue capsule. Malignant fibrosarcoma grows quickly and provokes the formation of effusion in the pleural cavity.

Hemangiomas- tumors from blood vessels are quite rare in the mediastinum, but usually affect its anterior section. Neoplasms from lymphatic vessels - lymphangiomas, hygromas - are usually found in children, form nodes, and can grow into the neck, causing displacement of other organs. Uncomplicated forms are asymptomatic.

Mediastinal cyst- This is a tumor-like process, which is a rounded cavity. Cysts can be congenital or acquired. Congenital cysts are considered a consequence of a disorder of embryonic development, and their source can be tissue of the bronchus, intestines, pericardium, etc. - bronchogenic, enterogenic cystic formations, teratomas. Secondary cysts are formed from the lymphatic system and tissues that are normally present here.

Symptoms of mediastinal tumors

For a long time, a mediastinal tumor can grow hidden, and signs of the disease appear later, when compression of the surrounding tissues occurs, they grow, and metastasis begins. In such cases, pathology is detected during examination of the chest organs for other reasons.

The location, volume and degree of differentiation of the tumor determine the duration of the asymptomatic period. Malignant tumors grow faster, so the clinic appears earlier.

The main signs of mediastinal tumors include:

  1. Symptoms of compression or invasion of neoplasia into surrounding structures;
  2. General changes;
  3. Specific changes.

The main manifestation of the pathology is pain, which is associated with the pressure of the neoplasm or its invasion of nerve fibers. This sign is characteristic not only of immature, but also of completely benign tumor processes. The pain is on the side of the growth pathology, not too intense, nagging, can radiate to the shoulder, neck, interscapular area. With left-sided pain, it can be very similar to that of angina pectoris.

An increase in pain in the bones is considered an unfavorable symptom, which most likely indicates possible metastasis. For the same reason, pathological fractures are possible.

Characteristic symptoms appear when nerve fibers are involved in tumor growth:

  • Drooping of the eyelid (ptosis), recessed eye and dilated pupil due to neoplasia, sweating disorder, fluctuations in skin temperature indicate involvement of the sympathetic plexus;
  • Hoarseness of voice (the laryngeal nerve is affected);
  • Increased level of the diaphragm during germination of the phrenic nerves;
  • Sensitivity disorders, paresis and paralysis due to compression of the spinal cord and its roots.

One of the symptoms of compression syndrome is the narrowing of the venous lines by a tumor, more often the superior vena cava, which is accompanied by difficulty in venous outflow from the tissues of the upper body and head. Patients in this case complain of noise and a feeling of heaviness in the head, increasing when bending, pain in the chest, shortness of breath, swelling and cyanosis of the facial skin, dilation and overflow of blood in the neck veins.

The pressure of the neoplasm on the respiratory tract provokes coughing and difficulty breathing, and compression of the esophagus is accompanied by dysphagia, when it is difficult for the patient to eat.

General signs of tumor growth are weakness, decreased performance, fever, sweating, weight loss, which indicate the malignancy of the pathology. The progressive enlargement of the tumor causes intoxication with the products of its metabolism, which is associated with joint pain, edema, tachycardia, and arrhythmias.

Specific symptoms characteristic of certain types of mediastinal neoplasms. For example, lymphosarcoma causes itchy skin and sweating, while fibrosarcoma occurs with episodes of hypoglycemia. Intrathoracic goiter with elevated hormone levels is accompanied by signs of thyrotoxicosis.

Symptoms of a mediastinal cyst is associated with the pressure it exerts on neighboring organs, so the manifestations will depend on the size of the cavity. In most cases, cysts are asymptomatic and do not cause any discomfort to the patient.

When a large cystic cavity puts pressure on the mediastinal contents, shortness of breath, coughing, difficulty swallowing, a feeling of heaviness and chest pain may occur.

Dermoid cysts, which are a consequence of intrauterine development disorders, often give symptoms of cardiac and vascular disorders: shortness of breath, cough, heart pain, increased heart rate. When the cyst is opened into the lumen of the bronchus, a cough appears with the release of sputum, in which hair and fat are visible.

Dangerous complications of cysts are their ruptures with an increase in pneumothorax, hydrothorax, and the formation of fistulas in the chest cavities. Bronchogenic cysts can suppurate and lead to hemoptysis when opened into the lumen of the bronchus.

Thoracic surgeons and pulmonologists often encounter neoplasms in the mediastinal region. Given the variety of symptoms, diagnosing mediastinal pathology presents significant difficulties. To confirm the diagnosis, radiography, MRI, CT, as well as endoscopic procedures (bronchoscopy and mediastinoscopy) are used. A biopsy can definitively verify the diagnosis.

Video: lecture on the diagnosis of tumors and mediastinal cysts

Treatment

Surgery is recognized as the only correct method of treatment for mediastinal tumors. The sooner it is performed, the better the prognosis for the patient. For benign formations, open intervention is performed with complete excision of the focus of neoplasia growth. In case of malignancy of the process, the most radical removal is indicated, and depending on the sensitivity to other types of antitumor treatment, chemotherapy and radiation therapy are prescribed, both independently and in combination with surgery.

When planning a surgical procedure, it is extremely important to choose the right approach that will give the surgeon the best view and space for manipulation. The likelihood of relapse or progression of the pathology depends on the radicality of the removal.

Radical removal of tumors in the mediastinal area is performed by thoracoscopy or thoracotomy - anterolateral or lateral. If the pathology is located retrosternally or on both sides of the chest, longitudinal sternotomy with incision of the sternum is considered preferable.

Videothoracoscopy- a relatively new method of treating a mediastinal tumor, in which the intervention is accompanied by minimal surgical trauma, but, at the same time, the surgeon has the opportunity to examine the affected area in detail and remove the altered tissue. Videothoracoscopy allows achieving high treatment results even in patients with serious underlying pathology and a small functional reserve for further recovery.

In case of severe concomitant diseases that complicate surgery and anesthesia, palliative treatment is carried out in the form of tumor removal using transthoracic ultrasound or partial excision of tumor tissue to decompress mediastinal formations.

Video: lecture on surgery for mediastinal tumors

Forecast for mediastinal tumors is ambiguous and depends on the type and degree of differentiation of the tumor. For thymomas, cysts, retrosternal goiter, mature connective tissue neoplasia, it is favorable provided they are removed in a timely manner. Malignant tumors not only compress and grow into organs, disrupting their function, but also actively metastasize, which leads to an increase in cancer intoxication, the development of serious complications and the death of the patient.

The author selectively answers adequate questions from readers within his competence and only within the OnkoLib.ru resource. Face-to-face consultations and assistance in organizing treatment are not provided at this time.

A mediastinal tumor is a neoplasm in the mediastinal space of the chest, which can vary in morphological structure. Benign neoplasms are often diagnosed, but approximately every third patient is diagnosed with oncology.

There are a large number of predisposing factors that determine the appearance of a particular formation, ranging from addiction to bad habits and dangerous working conditions, ending with metastasis of a cancer tumor from other organs.

The disease manifests itself in a large number of pronounced symptoms that are quite difficult to ignore. The most characteristic external signs include severe cough, shortness of breath, headaches and increased body temperature.

The basis of diagnostic measures is instrumental examinations of the patient, the most informative of which is considered to be a biopsy. In addition, a medical examination and laboratory tests will be required. Treatment of the disease, regardless of the nature of the tumor, is only surgical.

Etiology

Despite the fact that tumors and cysts of the mediastinum are a rather rare disease, its occurrence in most cases is caused by the spread of the oncological process from other internal organs. However, there are a number of predisposing factors, among which it is worth highlighting:

  • long-term addiction to bad habits, in particular smoking. It is worth noting that the more experience a person has of smoking cigarettes, the greater the likelihood of acquiring such an insidious disease;
  • decreased immune system;
  • contact with toxins and heavy metals - this includes both working conditions and unfavorable environmental conditions. For example, living near factories or industrial enterprises;
  • constant exposure to ionizing radiation;
  • prolonged nervous overstrain;
  • poor nutrition.

This disease occurs equally in both sexes. The main risk group consists of people of working age - from twenty to forty years. In rare cases, malignant or benign neoplasms of the mediastinum can be diagnosed in a child.

The danger of the disease lies in the wide variety of tumors, which may differ in their morphological structure, damage to vital organs and the technical complexity of their surgical excision.

The mediastinum is usually divided into three floors:

  • upper;
  • average;
  • lower.

In addition, there are three sections of the lower mediastinum:

  • front;
  • rear;
  • average.

Depending on the part of the mediastinum, the classification of malignant or benign neoplasms will differ.

Classification

According to the etiological factor, mediastinal tumors and cysts are divided into:

  • primary – originally formed in this area;
  • secondary – characterized by the spread of metastases from malignant tumors that are located outside the mediastinum.

Since primary neoplasms are formed from various tissues, they will be divided into:

  • neurogenic tumors of the mediastinum;
  • mesenchymal;
  • lymphoid;
  • thymus tumors;
  • dysembryogenetic;
  • germ cell - develop from the primary germ cells of the embryo, from which sperm and eggs should normally be formed. It is these tumors and cysts that are found in children. There are two peaks of incidence - in the first year of life and in adolescence - from fifteen to nineteen years.

There are several most common types of neoplasms, which will differ in their location. For example, tumors of the anterior mediastinum include:

  • neoplasms of the thyroid gland. They are often benign, but sometimes they are cancerous;
  • thymoma and thymic cyst;
  • mesenchymal tumors;

In the middle mediastinum, the most common formations are:

  • bronchogenic cysts;
  • lymphomas;
  • pericardial cysts.

A tumor of the posterior mediastinum manifests itself:

  • enterogenous cysts;
  • neurogenic tumors.

In addition, clinicians usually distinguish between true cysts and pseudotumors.

Symptoms

For quite a long period of time, tumors and cysts of the mediastinum can occur without expressing any symptoms. The duration of this course is determined by several factors:

  • place of formation and volume of neoplasms;
  • their malignant or benign nature;
  • the rate of tumor or cyst growth;
  • relationship with other internal organs.

In most cases, asymptomatic mediastinal tumors are discovered completely by accident - during fluorography for another disease or for preventive purposes.

As for the period of expression of symptoms, regardless of the nature of the tumor, the first sign is pain in the chest area. Its appearance is caused by compression or germination of the formation into the nerve plexuses or endings. The pain is often moderate. The possibility of pain radiating to the area between the shoulder blades, shoulders and neck cannot be ruled out.

Against the background of the main manifestation, other symptoms of mediastinal tumors begin to appear. Among them:

  • fatigue and malaise;
  • increased body temperature;
  • severe headaches;
  • bluish lips;
  • dyspnea;
  • swelling of the face and neck;
  • cough - sometimes with blood;
  • uneven breathing, even attacks of suffocation;
  • heart rate instability;
  • profuse sweating, especially at night;
  • causeless weight loss;
  • increase in the volume of lymph nodes;
  • hoarseness of voice;
  • night snoring;
  • increased blood pressure;
  • slurred speech;
  • disruption of the process of chewing and swallowing food.

In addition to the above symptoms, myasthenic syndrome very often appears, which is manifested by muscle weakness. For example, a person cannot turn his head, open his eyes, or raise his leg or arm.

Similar clinical manifestations are typical for mediastinal tumors in children and adults.

Diagnostics

Despite the variety and specificity of the symptoms of such a disease, it is quite difficult to establish a correct diagnosis based on them. For this reason, the attending physician prescribes a whole range of diagnostic examinations.

Primary diagnosis includes:

  • a detailed interview with the patient will help determine the first time of onset and the degree of intensity of symptom expression;
  • a clinician’s examination of the patient’s medical history and life history to determine the primary or secondary nature of the tumors;
  • a thorough physical examination, which should include auscultation of the patient’s lungs and heart using a phonendoscope, examination of the condition of the skin, and measurement of temperature and blood pressure.

General laboratory diagnostic methods do not have any particular diagnostic value; however, clinical and biochemical blood tests are necessary. A blood test is also prescribed to determine tumor markers that will indicate the presence of a malignant neoplasm.

In order to determine the location and nature of the neoplasm according to the classification of the disease, it is necessary to carry out instrumental examinations, including:


Treatment

After confirming the diagnosis, a benign or malignant mediastinal tumor should be surgically removed.

Surgical treatment can be carried out in several ways:

  • longitudinal sternotomy;
  • anterolateral or lateral thoracotomy;
  • transthoracic ultrasound aspiration;
  • radical extended surgery;
  • palliative removal.

In addition, if the tumor is malignant, treatment is supplemented with chemotherapy, which is aimed at:

  • reduction of the volume of malignant formation - carried out before the main operation;
  • the final elimination of cancer cells that may not have been completely removed during surgery;
  • elimination of a tumor or cyst - in cases where surgical therapy cannot be performed;
  • maintaining the condition and prolonging the patient’s life – when diagnosing a severe form of the disease.

Along with chemotherapy, radiation treatment can be used, which can also be the main or auxiliary technique.

There are several alternative methods to combat benign tumors. The first of them consists of a three-day fast, during which you need to refuse any food, and you are allowed to drink only purified water without gas. When choosing such treatment, you must consult with your doctor, since fasting has its own rules.

The therapeutic diet, which is part of complex therapy, includes:

  • frequent and fractional food consumption;
  • complete rejection of fatty and spicy foods, offal, canned food, smoked meats, pickles, sweets, meat and dairy products. It is these ingredients that can cause the degeneration of benign cells into cancerous ones;
  • enriching the diet with legumes, dairy products, fresh fruits, vegetables, cereals, dietary first courses, nuts, dried fruits and herbs;
  • cooking food only by boiling, steaming, stewing or baking, but without adding salt and fat;
  • plenty of drinking regime;
  • control over the temperature of food - it should not be too cold or too hot.

In addition, there are several folk remedies that will help prevent the onset of cancer. The most effective of them include:

Potato flowers will help
prevent cancer

  • potato flowers;
  • hemlock;
  • honey and mumiyo;
  • Golden mustache;
  • apricot kernels;
  • sagebrush;
  • white mistletoe.

It is worth noting that starting such therapy on your own can only aggravate the course of the disease, which is why you should consult with your doctor before using traditional recipes.

Prevention

There are no specific preventive measures that can prevent the appearance of a tumor in the anterior mediastinum or any other location. People need to follow a few general rules:

  • give up alcohol and cigarettes forever;
  • follow safety rules when working with toxins and poisons;
  • If possible, avoid emotional and nervous stress;
  • follow nutritional recommendations;
  • strengthen immunity;
  • undergo fluorographic examination annually for preventive purposes.

There is no unambiguous prognosis for such a pathology, since it depends on several factors - location, volume, stage of development, origin of the tumor, the age category of the patient and his condition, as well as the possibility of surgery.

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The mediastinum is an anatomical space, the middle region of the chest. The mediastinum is limited in front by the sternum, and in the back by the spine. On the sides of this organ there are pleural cavities.

For various purposes (surgery, planning radiation therapy, describing the localization of pathology), the mediastinum, in accordance with the scheme proposed by Twining in 1938, is divided into upper and lower, as well as anterior, posterior and middle sections.

Anterior, middle, posterior mediastinum

The anterior mediastinum is limited in front by the sternum, in the back by the brachiocephalic veins, pericardium and brachiocephalic trunk. In this space there are the internal mammary veins, the thoracic artery, the mediastinal lymph nodes and the thymus gland.

Structure of the middle mediastinum: heart, vena cava, brachiocephalic veins and brachiocephalic trunk, aortic arch, ascending aorta, phrenic veins, main bronchi, trachea, pulmonary veins and arteries.

The posterior mediastinum is limited by the trachea and pericardium in the anterior part, and in the posterior part by the spine. This part of the organ contains the esophagus, descending aorta, thoracic lymphatic duct, semi-gyzygos and azygos veins, as well as the posterior lymph nodes of the mediastinum.

Superior and inferior mediastinum

The superior mediastinum includes all the anatomical structures that lie above the upper edge of the pericardium: its boundaries are the superior sternal aperture and the line drawn between the angle of the chest and the intervertebral disc Th4-Th5.

The inferior mediastinum is limited by the superior edges of the diaphragm and pericardium and, in turn, is also divided into anterior, middle and posterior parts.

Classification of mediastinal tumors

Neoplasms of the organ are considered not only true tumors of the mediastinum, but also tumor-like diseases and cysts that differ in etiology, localization and course of the disease. Each of the mediastinal neoplasms originates from tissues of different origins, united only by anatomical boundaries. They are divided into:

Mediastinal tumors are detected mainly in young and middle age with equal frequency in both men and women. Despite the fact that mediastinal diseases may not manifest themselves for a long time and are detected only during a preventive study, there are several symptoms that characterize disorders of this anatomical space:

  • Mild pain localized at the site of the tumor and radiating to the neck, shoulder, and interscapular area;
  • Dilation of the pupil, drooping of the eyelid, retraction of the eyeball - can occur if the tumor grows in the borderline sympathetic trunk;
  • Hoarseness of voice – originates from damage to the recurrent laryngeal nerve;
  • Heaviness, noise in the head, shortness of breath, chest pain, cyanosis and swelling of the face, swelling of the veins of the chest and neck;
  • Impaired passage of food through the esophagus.

In the later stages of mediastinal diseases, increased body temperature, general weakness, arthralgic syndrome, cardiac arrhythmia, and swelling of the extremities are observed.

Mediastinal lymphadenopathy

Lymphadenopathy or enlargement of the lymph nodes of a given organ is observed with metastases of carcinoma, lymphomas, as well as some non-tumor diseases (sarcoidosis, tuberculosis, etc.).

The main symptom of the disease is generalized or localized enlargement of the lymph nodes, however, mediastinal lymphadenopathy may have additional manifestations such as:

  • Increased body temperature, sweating;
  • Loss of body weight;
  • Frequent infection of the upper respiratory tract (tonsillitis, pharyngitis, tonsillitis);
  • Hepatomegaly and splenomegaly.

Damage to the lymph nodes, characteristic of lymphomas, can be isolated or combined with the germination of tumors into other anatomical structures (trachea, blood vessels, bronchi, pleura, esophagus, lungs).