Medicinal reference book geotar. Vitamin B1 (Thiamin) review and beneficial properties for the body

Trade name of the drug: Thiamine chloride

International nonproprietary name:

Chemical name:(4-methyl-5-beta-oxyethyl-N-(2methyl-4-amino-5 methylpyrimidyl)-thiazolium chloride hydrochloride).

Dosage form:

Compound:

Description: Colorless or slightly colored transparent liquid with a weak characteristic odor.

Pharmacotherapeutic group:

Pharmacological properties
Vitamin B1 (thiamine) is a water-soluble vitamin. In the human body, as a result of phosphorylation processes, it is converted into cocarboxylase, which is a coenzyme of many enzymatic reactions. Plays an important role in carbohydrate, protein and fat metabolism, in the processes of conducting nervous excitation in synapses.

Indications for use
Hypovitaminosis and vitamin B1 deficiency. In complex therapy: neuritis, radiculitis; neuralgia; peripheral paresis; paralysis; intestinal atony; myocardial dystrophy; coronary circulation disorders; thyrotoxicosis; malabsorption in the intestine, endarteritis, psoriasis, eczema, intoxication.

Contraindications
Increased individual sensitivity.

Directions for use and doses
The drug is used as prescribed by a doctor.
Thiamine solution 5% is administered intramuscularly. It is recommended to start administering the drug with small doses (no more than 0.5 ml of a 5% solution) and only if well tolerated, move on to higher doses.
Intramuscularly for adults, 0.05 g of thiamine (1 ml of 5% solution) 1 time per day, daily. The course of treatment is 10-30 injections.

Side effect
Allergic reactions are possible (skin itching, urticaria, Quincke's edema, anaphylactic shock), sweating, tachycardia, and sometimes pain at the injection site (due to the low pH of solutions).

Interaction with other drugs
Simultaneous parenteral administration of thiamine and pyridoxine (vitamin B6) or cyanocobalamin (vitamin B12) is not recommended. B12 enhances the allergenic effect of thiamine. B 6 makes it difficult to convert thiamine into its biologically active form. You should not mix vitamin B1 and penicillin or streptomycin (destruction of antibiotics), vitamin B1 and nicotinic acid (destruction of vitamin B1) in the same syringe.

Thiamine reduces the pharmacological activity of suxamethonium iodide, redergam, phentolamine, anaprilin, sympatholytics (reserpine, octadine), hypnotics (hypnotic and hypotensive effects are reduced).

Thiamine solution should not be mixed with solutions containing sulfites, because in them it completely disintegrates.

Release form
Ampoules 1 ml. 10 ampoules in cardboard packs.

Storage conditions
Store in a place protected from light. At temperatures Keep out of reach of children.

Best before date
3 years.
Do not use after the expiration date indicated on the package.

Conditions for dispensing from pharmacies.
Dispensed with a doctor's prescription.

Manufacturer's name and address
OJSC "Yerevan Chemical-Pharmaceutical Company" Armenia 375040, Yerevan, Adjaryan str. 2nd lane, 6.

Complaint address:
LLC "StatusPharm"
109316, Moscow, Ostapovsky pr-d, 5, building 1

Dosage form: capsules, solution for intramuscular administration, tablets, film-coated tablets

Pharmachologic effect: Vitamin B1. In the body, as a result of phosphorylation processes, it is converted into cocarboxylase, which is a coenzyme of many enzymatic reactions. Plays an important role in carbohydrate, protein and fat metabolism, as well as in the processes of nerve excitation at synapses. Protects cell membranes from the toxic effects of peroxidation products.

Indications: Hypovitaminosis and vitamin B1 deficiency, incl. in patients on tube feeding, hemodialysis, and with malabsorption syndrome. As part of complex therapy - burns, prolonged fever, neuritis and polyneuritis, radiculitis, neuralgia, peripheral paresis and paralysis, Wernicke's encephalopathy, Korsakoff's psychosis, chronic liver damage, various intoxications, myocardial dystrophy, coronary circulatory disorders, peptic ulcer of the stomach and duodenum , atonic constipation, intestinal atony, sprue, thyrotoxicosis, diabetes mellitus, endarteritis; dermatoses (eczema, atopic dermatitis, psoriasis, lichen planus) with neurotrophic changes and metabolic disorders; hemodialysis, pyoderma, prolonged physical and psychological stress, during pregnancy and lactation, maintaining diets.

Contraindications: Hypersensitivity. Caution. Wernicke encephalopathy, premenopausal and menopausal periods in women.

Side effects: Allergic reactions (urticaria, itching, angioedema, rarely - anaphylactic shock), increased sweating, tachycardia. Pain (due to the low pH of solutions) with subcutaneous injection, less often with intramuscular injection.

Directions for use and dosage: Vitamin B1 is taken orally, intramuscularly, intravenously, subcutaneously. Daily requirement for vitamin B1: for adult men - 1.2-2.1 mg; for elderly people - 1.2-1.4 mg; for women - 1.1-1.5 mg (in pregnant women 0.4 mg more, in nursing women - 0.6 mg more); for children, depending on age - 0.3-1.5 mg. It is recommended to start parenteral administration with small doses (no more than 0.5 ml of a 5-6% solution) and only if well tolerated, higher doses are administered. IM (deep into the muscle), IV (slowly), less often - s/c. Adults are prescribed 20-50 mg of thiamine chloride (1 ml of 2.5-5% solution) or 30-60 mg of thiamine bromide (1 ml of 3-6% solution) 1 time per day, daily, switching to oral administration; children - 12.5 mg of thiamine chloride (0.5 ml of 2.5% solution) or 15 mg of thiamine bromide (0.5 ml of 3% solution). The course of treatment is 10-30 injections. Orally, after meals, adults for preventive purposes - 5-10 mg/day, for therapeutic purposes - 10 mg per dose 1-5 times a day, maximum dose - 50 mg/day. The course of treatment is 30-40 days. Children under 3 years of age - 5 mg every other day; 3-8 years - 5 mg 3 times a day, every other day. The course of treatment is 20-30 days.

Special indications: When taking the recommended doses during pregnancy, breastfeeding, as well as in the elderly, no adverse reactions other than those mentioned above were observed. When determining theophylline in blood serum by the spectrophotometric method, urobilinogen using the Ehrlich reagent can distort the results (when taking high doses). More often, an anaphylactic reaction develops after intravenous administration of large doses. Do not use as a replacement for balanced nutrition, only in combination with diet therapy. Parenteral administration is recommended only if oral administration is not possible (nausea, vomiting, malabsorption syndrome, preoperative and/or postoperative conditions). In Wernicke encephalopathy, dextrose should be given before thiamine.

Interaction with other drugs: Thiamine chloride solution should not be mixed with solutions containing sulfites, because in them it completely disintegrates. Simultaneous parenteral administration of thiamine with pyridoxine or cyanocobalamin is not recommended: pyridoxine makes it difficult to convert thiamine into a biologically active form, cyanocobalamin increases the allergenic effect of thiamine. Do not mix thiamine with benzylpenicillin or streptomycin (destruction of antibiotics), thiamine and nicotinic acid (destruction of thiamine) in the same syringe. Weakens the effect of depolarizing muscle relaxants (suxamethonium iodide, etc.). Thiamine is unstable in alkaline and neutral solutions; administration with carbonates, citrates, barbiturates with Cu2+ is not recommended. When administered intravenously simultaneously with solutions containing sodium hydrosulfite as an antioxidant or preservative, thiamine is unstable. Ethanol slows the rate of absorption of thiamine after oral administration.

capsules, solution for intramuscular administration, tablets, film-coated tablets

Pharmachologic effect:

Vitamin B1. In the body, as a result of phosphorylation processes, it is converted into cocarboxylase, which is a coenzyme of many enzymatic reactions. Plays an important role in carbohydrate, protein and fat metabolism, as well as in the processes of nerve excitation at synapses. Protects cell membranes from the toxic effects of peroxidation products.

Indications:

Hypovitaminosis and vitamin B1 deficiency, incl. in patients on tube feeding, hemodialysis, and with malabsorption syndrome. As part of complex therapy - burns, prolonged fever, neuritis and polyneuritis, radiculitis, neuralgia, peripheral paresis and paralysis, Wernicke's encephalopathy, Korsakoff's psychosis, chronic liver damage, various intoxications, myocardial dystrophy, coronary circulatory disorders, peptic ulcer of the stomach and duodenum , atonic constipation, intestinal atony, sprue, thyrotoxicosis, diabetes mellitus, endarteritis; dermatoses (eczema, atopic dermatitis, psoriasis, lichen planus) with neurotrophic changes and metabolic disorders; hemodialysis, pyoderma, prolonged physical and psychological stress, during pregnancy and lactation, maintaining diets.

Contraindications:

Hypersensitivity. Caution. Wernicke encephalopathy, premenopausal and menopausal periods in women.

Side effects:

Allergic reactions (urticaria, itching, angioedema, rarely - anaphylactic shock), increased sweating, tachycardia. Pain (due to the low pH of solutions) with subcutaneous injection, less often with intramuscular injection.

Directions for use and dosage:

Vitamin B1 is taken orally, intramuscularly, intravenously, subcutaneously. Daily requirement for vitamin B1: for adult men - 1.2-2.1 mg; for elderly people - 1.2-1.4 mg; for women - 1.1-1.5 mg (in pregnant women 0.4 mg more, in nursing women - 0.6 mg more); for children, depending on age - 0.3-1.5 mg. It is recommended to start parenteral administration with small doses (no more than 0.5 ml of a 5-6% solution) and only if well tolerated, higher doses are administered. IM (deep into the muscle), IV (slowly), less often - s/c. Adults are prescribed 20-50 mg of thiamine chloride (1 ml of 2.5-5% solution) or 30-60 mg of thiamine bromide (1 ml of 3-6% solution) 1 time per day, daily, switching to oral administration; children - 12.5 mg of thiamine chloride (0.5 ml of 2.5% solution) or 15 mg of thiamine bromide (0.5 ml of 3% solution). The course of treatment is 10-30 injections. Orally, after meals, adults for preventive purposes - 5-10 mg/day, for therapeutic purposes - 10 mg per dose 1-5 times a day, maximum dose - 50 mg/day. The course of treatment is 30-40 days. Children under 3 years of age - 5 mg every other day; 3-8 years - 5 mg 3 times a day, every other day. The course of treatment is 20-30 days.

Special instructions:

When taking the recommended doses during pregnancy, breastfeeding, as well as in the elderly, no adverse reactions other than those mentioned above were observed. When determining theophylline in blood serum by the spectrophotometric method, urobilinogen using the Ehrlich reagent can distort the results (when taking high doses). More often, an anaphylactic reaction develops after intravenous administration of large doses. Do not use as a replacement for balanced nutrition, only in combination with diet therapy. Parenteral administration is recommended only if oral administration is not possible (nausea, vomiting, malabsorption syndrome, preoperative and/or postoperative conditions). In Wernicke encephalopathy, dextrose should be given before thiamine.

Interaction:

Thiamine chloride solution should not be mixed with solutions containing sulfites, because in them it completely disintegrates. Simultaneous parenteral administration of thiamine with pyridoxine or cyanocobalamin is not recommended: pyridoxine makes it difficult to convert thiamine into a biologically active form, cyanocobalamin increases the allergenic effect of thiamine. Do not mix thiamine with benzylpenicillin or streptomycin (destruction of antibiotics), thiamine and nicotinic acid (destruction of thiamine) in the same syringe. Weakens the effect of depolarizing muscle relaxants (suxamethonium iodide, etc.). Thiamine is unstable in alkaline and neutral solutions; administration with carbonates, citrates, barbiturates with Cu2+ is not recommended. When administered intravenously simultaneously with solutions containing sodium hydrosulfite as an antioxidant or preservative, thiamine is unstable. Ethanol slows the rate of absorption of thiamine after oral administration.

Before using the drug Vitamin B1 consult your doctor!

Thiamine is also called vitamin B1 - it is one of the most important representatives of the “B” group. Basically, it is responsible for biochemical processes in the body, the normal production of certain enzymes and the stability of the nervous system.

How does vitamin thiamine work?

Biochemical processes are constantly taking place in the human body, and vitamin B1 is converted into the necessary cocarboxylase. Without it, some vital biochemical reactions and normal functioning of the body are impossible. If the patient decides to use thiamine, the instructions for use must be studied and stored. This vitamin directly affects fat, water and even carbohydrate metabolism, not to mention ensuring normal transmission of impulses in synapses.

Thiamine: instructions for use and release form

Traditionally, this vitamin is produced in the form of gelatin capsules, tablets and injection solutions. It is prescribed for chronic vitamin deficiency or the presence of hypovitaminosis. Only thiamine exhibits the ability to restore natural balance in the body. The instructions suggest using vitamin B1 to treat bedsores, neuritis, non-healing old ulcers, burns and radiculitis. It is also included in the complex therapy of diseases such as dermatitis or persistent dermatosis. The positive effect on the nervous system allows the vitamin to be used in the treatment of psychoses, any psychoneurotic conditions, paralysis and depression.

How doctors prescribe thiamine: instructions for use

Depending on what exactly the doctor prescribed, the vitamin is taken parenterally, that is, intravenously, and orally. The dose of the drug must be prescribed by a doctor after appropriate tests and examination; exceeding the permissible dose can lead to dangerous and unpleasant consequences. Instructions for use will not help in injecting thiamine correctly; you need a qualified doctor and clearly selected dosages. Begin a course of treatment with vitamin B1 by administering 0.5 ml of the prepared solution. After checking the body's response to the injection, the dosage may be increased. To avoid pain, when administered intramuscularly, the puncture is carried out to the deep layers of the muscles. In the case of intravenous injection, the thiamine solution is administered very carefully and as slowly as possible. The full course of treatment rarely exceeds 30 days.

Contraindications and side effects of vitamin B1

Before starting treatment, a test for hypersensitivity to thiamine is required. It is advisable to carry out the first injection in the presence of the attending physician. Women in the postmenopausal period and during menopause are not recommended to use large doses of vitamin B1 and use the drug with great caution. Side effects of thiamine include frequent allergic reactions. Temporary tachycardia and increased sweating may occur. If the vitamin is intended for children, you need to remember that when administered subcutaneously, the solution dissolves quite painfully. If it is impossible to tolerate pain, it is better to use thiamine in the form of tablets or capsules, and in rare cases, as injections into a vein.

International name - vitamin B1

Composition and release form.

The solution for intramuscular administration is clear, colorless or almost colorless with a slight characteristic odor. 1 ml contains thiamine hydrochloride 50 mg.

Excipients: disodium edetate 0.1 mg, water up to 1 ml.

Solution for intramuscular injection 50 mg/ml: amp. 1 ml 10 pcs.

1 ml - ampoules (10) - contour cell packaging (1) - cardboard packs.

Pharmachologic effect.

Vitamin B1 is a water-soluble vitamin. In the human body, as a result of phosphorylation processes, it is converted into cocarboxylase, which is a coenzyme of many enzymatic reactions. Vitamin B1 plays an important role in carbohydrate, protein and fat metabolism, as well as in the processes of nerve excitation at synapses.

Pharmacokinetics.

After oral administration, it is absorbed from the gastrointestinal tract. Before absorption, thiamine is released from its bound state by digestive enzymes. After 15 minutes, thiamine is detected in the blood, and after 30 minutes - in other tissues. The content of thiamine in the blood is relatively low, while predominantly free thiamine is found in plasma, and its phosphorus esters are found in erythrocytes and leukocytes.

The distribution in the body is quite wide. A relative predominance of thiamine content in the myocardium, skeletal muscles, nervous tissue, and liver was noted, which is apparently associated with an increased consumption of thiamine by these structures. Half of the total amount of thiamine is found in striated muscles (including myocardium) and about 40% in internal organs. The most active of the phosphorus esters of thiamine is thiamine diphosphate. This compound has coenzyme activity and plays a major role in the participation of thiamine in the metabolism of fats and carbohydrates.

Excreted through the intestines and kidneys.

Indications for the use of vitamin b1.

Hypovitaminosis and vitamin B1 deficiency, incl. in patients on tube feeding, hemodialysis, and with malabsorption syndrome. As part of complex therapy - burns, prolonged fever, neuritis and polyneuritis, radiculitis, neuralgia, peripheral paresis and paralysis, Wernicke's encephalopathy, Korsakoff's psychosis, chronic liver damage, various intoxications, myocardial dystrophy, coronary circulatory disorders, peptic ulcer of the stomach and duodenum , atonic constipation, intestinal atony, sprue, thyrotoxicosis, diabetes mellitus, endarteritis; dermatoses (eczema, atopic dermatitis, psoriasis, lichen planus) with neurotrophic changes and metabolic disorders; hemodialysis, pyoderma, prolonged physical and psychological stress, during pregnancy and lactation, maintaining diets.

Dosage regimen and method of application.

Inside, intramuscularly, intravenously, subcutaneously. Daily requirement for vitamin B1: for adult men - 1.2-2.1 mg; for elderly people - 1.2-1.4 mg; for women - 1.1-1.5 mg (in pregnant women 0.4 mg more, in nursing women - 0.6 mg more); for children, depending on age - 0.3-1.5 mg. It is recommended to start parenteral administration with small doses (no more than 0.5 ml of a 5-6% solution) and only if well tolerated, higher doses are administered. IM (deep into the muscle), IV (slowly), less often - s/c.

Adults are prescribed 20-50 mg of thiamine chloride (1 ml of 2.5-5% solution) or 30-60 mg of thiamine bromide (1 ml of 3-6% solution) 1 time per day, daily, switching to oral administration; children - 12.5 mg of thiamine chloride (0.5 ml of 2.5% solution) or 15 mg of thiamine bromide (0.5 ml of 3% solution). The course of treatment is 10-30 injections. Orally, after meals, adults for preventive purposes - 5-10 mg/day, for therapeutic purposes - 10 mg per dose 1-5 times a day, maximum dose - 50 mg/day. The course of treatment is 30-40 days. Children under 3 years of age - 5 mg every other day; 3-8 years - 5 mg 3 times a day, every other day. The course of treatment is 20-30 days.

Side effect vitamin b1.

Allergic reactions: urticaria, skin itching, Quincke's edema; in isolated cases - anaphylactic shock.

Others: sweating, tachycardia.

Contraindications for use.

Hypersensitivity to thiamine.

Use during pregnancy and breastfeeding.

Can be used during pregnancy and lactation according to indications in recommended doses.

Special instructions for use vitamin b1.

Allergic reactions to the administration of thiamine occur more often in individuals predisposed to allergies.

SC (and sometimes IM) injections of thiamine are painful due to the low pH of the solutions.