How to take duovit vitamins for women. Duovit instructions for use, contraindications, side effects, reviews. Special instructions for the use of Duovit

There are currently a large number of complexes on the modern pharmaceutical market, where multivitamins and minerals act as active ingredients. They have a beneficial effect on the human body, improving its well-being. However, the question of their choice is too acute for a sufficient number of people. Thus, Duovit vitamins are considered one of the best nutritional supplements that help normalize the functioning of internal organs and their systems. Before using them, it is important to consult with a specialist and study the instructions.

Instructions for use

The complex is manufactured by the Slovenian pharmaceutical company KRKA, d.d. Duovit is prescribed not only for preventive purposes, but also for therapeutic purposes, depending on the situation in which a person needs help. Many people doubt the effectiveness of the complex, and therefore try to find the maximum amount of information about its composition and beneficial properties. In addition, it is important to pay attention to the available indications for use and contraindications in order to prevent a worsening of your own condition if the drug is used incorrectly.

Release form

"Duovit" is offered to consumers in tablet form. Each cardboard package contains four blisters, each of which contains 10 capsules of different colors. This color distinction was developed specifically so that a person does not get confused about which pill to take in the morning and which in the evening. In addition, the composition of the red and blue tablets is different from each other.

Compound

The color division of the dragees was developed for better absorption by the human body of the nutrients they contain. As you know, in the morning some vitamins and minerals are absorbed faster than in the evening, for example. For this reason, it is necessary to strictly follow the sequence of taking the pills.

Red dragee

The reddish capsules contain only vitamins. These include elements belonging to groups such as:

Blue jelly bean

Considering the fact that Duovit contains not only vitamins, but also minerals, and the red tablet is filled only with the former, the blue dragee is a keeper of macro- and microelements. These include:

These substances determine the beneficial properties of the complex and determine its positive effect on the human body.

Beneficial features

Multivitamins have the following beneficial properties:

• regulation of the functioning of the retina;
• regulation of the transformation of stem-type cells into erythroid-type cells;
• increasing resistance to microorganisms that cause various diseases;
• regulation of calcium content in the plasma component of the genetic material;
• ensuring the growth of bone tissue, its strengthening;
• optimization of the functioning of the renal organs;
• strengthening naturally acquired immunity;
• accelerating the production of insulin (important in case of its deficiency in the human body);
• removal of toxic substances;
• increasing stress resistance and ability to work;
• creation of additional energy reserves;
• improving the functioning of the digestive tract;
• accelerating the production of erythroid cells;
• improving the functioning of the visual organs;
• improving the functioning of skeletal muscles, normalizing the number of their contractions;
• getting rid of sleep disorders (insomnia, increased drowsiness);
• improved appetite;
• slowing down the aging process;
• improvement of appearance.

Considering the indicated properties of the complex, there are certain situations when its use is required. For preventive purposes, you can take the drug only after consultation with a specialist.

Indications for use

Many people are interested in the question of when to start taking this nutritional supplement. The main indications for its use are:

• a state of overstrain caused by increased physical, mental, emotional overload;
• the need for constant strength training and active rest;
• belonging to the age group over sixty years of age;
• the presence of bad habits such as smoking, alcoholism;
• improper organization of diet;
• attempts to follow restrictive diets (prescribed for diabetes mellitus, extreme obesity);
• spring-autumn vitamin deficiency;
• pregnancy and lactation period in women;
• recovery after severe dyspeptic disorders, diseases, surgical operations.

Contraindications

Despite the eleven vitamins and eight minerals in the complex, there are certain contraindications to its use. These include:

• hypersensitivity to the components of the drug;
• excess amount of vitamins A, D, E in the human body;
• dysfunction of the renal organs;
• formation of kidney stones;
• inability of the kidneys to remove uric acid, or more precisely, gout;
• increased amount of uric acid in the plasma component of the blood;
• erythremia;
• increased number of erythroid cells in the genetic material;
• thrombophlebitis;
• clogging of the lumens of blood vessels with thrombotic formations;
• individual fructose intolerance;
• increased amounts of calcium in urinary secretions and genetic material;
• hyperthyroidism;
• disruption of copper and iron metabolism;
• insufficient absorption of glucose and galactose in the intestinal area;
• insufficient functioning of the cardiovascular system;
• glomerular type nephritis, which is chronic;
• recovery period after sarcoidosis;
• acute tuberculosis;
• stomach and duodenal ulcers;
• children up to ten years of age.

Given the extensive list of contraindications, it is better to ask your doctor for advice before starting to take the complex. Otherwise, you can experience the negative effects of the product, called “side effects”. The drug should be taken with caution in the presence of diseases such as:

• liver dysfunction;
• previously suffered peptic ulcer;
• inflammatory processes in the kidney organs;
• decompensated functioning of the cardiovascular system;
• idiosyncrasy;
• cholelithiasis;
• diabetes;
• malignant and benign tumors.

Side effects

Negative effects from taking the Duovit complex can occur if it is taken incorrectly, for example, the dosage established by the manufacturer or specialist is not followed. The following side effects are observed:

• allergic reactions of varying severity;
• pain in the head, dizziness, hypersomnia;
• the sensation of “goosebumps running over the skin”;
• visual impairment;
• dyspeptic disorders, flatulence, nausea, turning into vomiting;
• increased body temperature;
• deterioration in general health;
• discoloration of urinary discharge;
• the appearance of large amounts of calcium in urinary secretions;
• arrhythmia;
• redness on the skin, rash, itching sensation;
• increased content of uric acid in the genetic material;
• increased sweating.

In order not to experience side effects from your own experience, it is enough to know how to take multivitamins correctly: together or separately. For children, the dosage is set separately.

How to use?

"Duovit" is used once a day. A red and a blue tablet are taken at the same time, washed down with a sufficient amount of water. It is recommended to take the complex in the morning after breakfast, since it is during this period that the vitamin and mineral components of the drug are best absorbed. When wondering how long to take Duovit, you should first decide for what purpose it is used. If used as a preventive measure, twenty to thirty days of use is enough to replenish the required amount of nutrients in the body. The interval between courses is from one to three months. It is installed by a specialist.

Analogues

The complex, like other vitamin food supplements, has certain analogues. There are no products that are completely identical to it, however, dietary supplements with similar effects are sufficient. These include:

• "Glutamevit";
• "Vitacap";
• "Menopace";
• " " and others.

Each of these food additives has specific indications and contraindications. Before using them, you should consult a specialist.

Dragee - 1 dragee:

• Active ingredients: retinol palmitate (Vit. A) 2.94 mg, α-tocopherol acetate (Vit. E) 10 mg, colecalciferol (Vit. D3) 200 mcg, ascorbic acid (Vit. C) 60 mg, thiamine mononitrate (Vit. B1 ) 1 mg, riboflavin (vit. B2) 1.2 mg, calcium pantothenate (vit. B5) 5 mg, pyridoxine hydrochloride (vit. B6) 2 mg, folic acid (vit. Bc) 400 mcg, cyanocobalamin* (vit. B12) 3 mcg, nicotinamide (Vit. PP) 13 mg.
• Excipients: lactose monohydrate, orange oil 05073, polysorbate 80, glycerol, purified castor oil, sorbitol, liquid dextrose, defoamer 1510, magnesium stearate, Opalux dye AS-F-2833G (Ponceau 4R crimson dye (E124), sunset yellow dye (E110)), emulsion wax, sucrose.

* cyanocobalamin 0.1% in mannitol (3 mg)

Dragee - 1 dragee:

• Active ingredients: calcium hydrogen phosphate dihydrate 64.5 mg, which corresponds to the calcium content (Ca2+) 15 mg, which corresponds to the phosphorus content (P5+) 12 mg, magnesium lactate dihydrate 200 mg, which corresponds to the magnesium content (Mg2+) 20 mg, iron fumarate 30.3 mg, which corresponds to the content of iron (Fe2+) 10 mg, copper sulfate pentahydrate 4 mg, which corresponds to the content of copper (Cu2+) 1 mg, zinc sulfate heptahydrate 13.3 mg, which corresponds to the content of zinc (Zn2+) 3 mg, manganese sulfate monohydrate 3.1 mg, which corresponds to manganese content (Mn2+) 1 mg, sodium molybdate dihydrate 220 μg, which corresponds to molybdenum content (Mo6+) 100 μg.
• Excipients: lactose monohydrate, orange oil 05073, polysorbate 80, glycerol, purified castor oil, sorbitol, liquid dextrose, defoamer 1510, magnesium stearate, liquid paraffin, povidone, indigo carmine dye AS-20912 Blue (E132), emulsion wax, sucrose.

10 pieces. (5 pcs. red dragees and 5 pcs. blue dragees) - blisters (4) - cardboard packs.

Description of the dosage form

Red dragees (vitamins) (20 pcs. per pack). Blue dragees (minerals) (20 pcs. per pack).

pharmachologic effect

A combined preparation containing a complex of 11 vitamins and 8 minerals, which are important factors in metabolic processes. One red and blue dragee contains vitamins and minerals in quantities that satisfy the body's daily needs. For better absorption of the vitamin-mineral complex and preservation of the activity of the main components, vitamins and minerals are separated in tablets of different colors. Vitamins are contained in red pellets, minerals are contained in blue pellets.

Vitamin A is involved in the synthesis of various substances (proteins, lipids, mucopolysaccharides) and ensures the normal function of the skin, mucous membranes, and the organ of vision.

Vitamin D3 plays an important role in maintaining the balance of calcium and phosphorus in the body. With its deficiency in bone tissue, the calcium content decreases (osteoporosis).

Vitamin B1 normalizes the activity of the heart and contributes to the normal functioning of the nervous system.

Vitamin B2 promotes tissue regeneration processes, including skin cells.

Vitamin B6 helps maintain the structure and function of bones, teeth, and gums; influences erythropoiesis and promotes the normal functioning of the nervous system.

Vitamin B12 is involved in erythropoiesis and contributes to the normal functioning of the nervous system. B vitamins are involved in the formation of various enzymes that regulate different types of metabolism in the body.

Folic acid stimulates erythropoiesis.

Vitamin E is a natural antioxidant. It prevents increased blood clotting and has a beneficial effect on peripheral circulation. Participates in the synthesis of proteins and hemoglobin, in the process of cell growth, the function of skeletal muscles, heart and blood vessels, gonads.

Vitamin C is involved in the oxidation of a number of biologically active substances, regulation of metabolism in connective tissue, carbohydrate metabolism, blood clotting and tissue regeneration, stimulates the formation of steroid hormones, and normalizes capillary permeability. Vitamin C increases the body's resistance to infections and reduces inflammatory reactions.

Calcium is involved in the formation of bone tissue, blood clotting, transmission of nerve impulses, contraction of skeletal and smooth muscles, and normal heart function. It also promotes iron absorption.

Magnesium is involved in the formation of muscle and bone tissue, and also takes part in protein synthesis.

Iron is part of the hemoglobin molecule, participates in the transport of oxygen in the body and prevents the development of anemia.

Phosphorus, along with calcium, is involved in the formation of bones and teeth, and is also involved in energy metabolism processes.

Manganese promotes bone mineralization.

Copper is necessary for normal red blood cell function and iron metabolism.

Zinc is necessary for tissue regeneration and is part of some hormones, including insulin.

Clinical pharmacology

Multivitamins.

Indications for use Duovit

As a prophylactic agent for conditions accompanied by an increased need for vitamins and minerals:

• increased physical activity, including during active sports;
• period of pregnancy and lactation;
• with irregular, poor nutrition or monotonous diet.

Contraindications to the use of Duovit

Hypersensitivity to the components of the drug.

Duovit Use during pregnancy and children

During pregnancy and lactation, the drug can be used as prescribed by a doctor.

Duovit Side effects

Possible: allergic reactions, including hypersensitivity reactions with an asthmatic component.

Drug interactions

The drug contains iron and calcium and therefore delays the absorption in the intestine of antibiotics from the tetracycline group, as well as antimicrobial agents - fluoroquinolone derivatives. Vitamin C enhances the effect and side effects of antimicrobial agents from the sulfonamide group (including the appearance of crystals in the urine). Antacids containing aluminum, magnesium, calcium, and cholisteramine reduce iron absorption. Therefore, if it is necessary to prescribe Duovit and antacid drugs together, it is necessary to maintain an interval between doses of at least 3 hours. With the simultaneous administration of diuretics from the thiazides group, the likelihood of hypercalcemia increases. It is not recommended to take Duovit together with other medications containing vitamins and minerals.

Dosage of Duovit

Inside, after breakfast. The pills should be swallowed whole with a small amount of water.

Adults and children over 10 years old - 1 red tablet and 1 blue tablet per day. The course of taking the drug is 20 days. The course of taking the drug can be repeated after a break (1-3 months) or as recommended by a doctor.

Precautionary measures

It is possible that urine may turn yellow - this is completely harmless and is explained by the presence of riboflavin in the drug.

Patients with diabetes need to know that each tablet contains 0.8 g of sugar, and the daily dose of the drug contains 1.6 g of sugar.

Red and blue Duovit tablets contain 331 mg of lactose, 1083 mg of sucrose, 270 mg of glucose, 237 mg of sorbitol, therefore it is not recommended for patients with congenital intolerance to glucose and fructose, with glucose/galactose malabsorption syndromes and sucrose/isomaltose deficiency.

The drug contains glycerol; in case of overdose, headaches and gastrointestinal disorders (diarrhea, vomiting) are possible. Azo dyes E 124 and E 110 can cause hypersensitivity reactions with an asthmatic component. Hypersensitivity reactions to the drug are possible in patients with hypersensitivity to acetylsalicylic acid.

Red dragees contain a polyol (mannitol), which in large doses can cause diarrhea.

You need to take vitamins correctly, since some of them enhance the effect of the substances contained in them, while others, on the contrary, slow them down. For example, Duovit allows you to consume vitamins and minerals separately.

Duovit: composition and properties of the red tablet

The Duovit complex is developed using a special formula that improves the absorption of vitamins and minerals necessary for health. Each package of the drug contains two different sets of substances, contained in red and blue tablets. The components they contain protect the body from premature aging, prevent the development of many diseases, strengthen bone tissue, and maintain beauty. Each dragee contains a certain set of useful substances. Red contains 11 vitamins that have a specific effect on the human body, and blue contains 8 microelements.

Retinol

One of the main components of the red pill is retinol - a synthetic “substitute”. Its ability to penetrate tissue is low, so taking special medications will help prevent problems associated with deficiency. Especially over 30 years old and those whose skin is prone to excessive oiliness.

Properties:

• decreased activity of the sebaceous glands and their cells;
• normalization of sebum composition;
• stopping the growth of malignant cells.

Tocopherol

Like retinol and ascorbic acid, they are antioxidants. It prolongs youth, preserves the beauty of the skin, protects the body from the harmful effects of the environment. Tocopherol is responsible for hormonal balance, maintaining normal cholesterol levels, and cardiovascular health.

Ascorbic acid

The second important component is vitamin C, which is responsible for human immunity. Its daily requirement is determined by gender, age, lifestyle and the presence/absence of bad habits. With participation, many hormones are synthesized, hematopoiesis occurs, collagen is produced, toxins are eliminated, and cells of the bone and cartilage system grow. Without vitamin C, the body ages faster.

Group B

Vitamins Duovit contain (thiamine), B2 (), (pyridoxine) and B12 (), each of which plays a specific role, but in combination with other members of the group is more effective than alone. Without it, normal functioning of the digestive and nervous systems is impossible. Their deficiency leads to increased blood sugar, insomnia, dry skin, hair loss, dizziness, photophobia, chronic fatigue and other problems.

Or vitamin B9 regulates the development of new cells, affects the activity of enzymes and the synthesis of blood cells. It rids the body of toxins and participates in the production of serotonin, the deficiency of which leads to prolonged depression. An additional effect is to improve the condition of hair, nails, and skin in both women and men.

The only vitamin that has been given the status of a medicine in traditional medicine. It effectively fights cholesterol and is important for blood circulation, as well as for the smooth functioning of the heart. With its participation, sugar and fats are converted into energy, and not into cellulite.

Calciferol

Participating in the metabolism of phosphorus and calcium, is responsible for the growth of skeletal tissues and bone strength. When it occurs, the functioning of the nervous system and endocrine glands is disrupted, and immunity is reduced.

Symptoms of problems associated with vitamin deficiency are:

• frequent fractures and slow healing of bones;
• deterioration in general health;
• increased fatigue against the background of decreased performance.

Vitamin E has radioprotective and antioxidant effects. It stimulates the supply of oxygen to cells, improves immunity, affects the tone and permeability of blood vessels, and regulates the functioning of the genital organs. Deficiency leads to decreased libido in men, menstrual irregularities in women, blurred vision, capillary fragility, hypotension and other troubles.

Composition of blue tablets

Blue tablets contain exclusively minerals.

Magnesium

Takes part in many processes occurring in the body. For example, in protein synthesis, antibody production, internal organ function, glucose absorption, and so on. Lack of the element leads to the development of cardiovascular diseases.

Calcium

Participates in muscle contraction and excitability of nerve fibers, affects blood clotting and membrane permeability, prevents the appearance and accumulation of cholesterol.

Iron

Responsible for metabolism and transport of oxygen to tissues. Without it, the removal of toxins slows down, cholesterol metabolism is disrupted, and calories turn into fat instead of becoming energy.

Copper

Affects the functioning of blood vessels, strengthens the immune system, takes part in the production of blood cells and energy metabolism. The mineral has a bactericidal, anti-inflammatory, and antibacterial effect. With its participation, iron is transported and female sex hormones are produced. It is believed that copper deficiency increases the risk of heart disease, obesity occurs, and the growth of malignant tumors is activated.

Zinc

It affects the functioning of the immune system and the production of the hormone thymulin. Without zinc, tissue regeneration worsens, taste sensations are impaired, atherosclerosis develops, and disorders in the functioning of the heart and genital organs are observed. Deficiency causes hair loss, lack of appetite, slow growth and frequent dermatitis.

Manganese

An important microelement that affects the functioning of almost all human systems and organs. It is necessary to regularly consume foods rich in manganese, otherwise wound healing will slow down, vitamin metabolism and the production of thyroid hormones will be disrupted, and the regulation of fat metabolism will deteriorate. When ingested in sufficient quantities, manganese has an antioxidant, immunomodulatory effect and stimulates reproductive function.

Molybdenum

Necessary for the metabolism of carbohydrates and fats, the production of amino acids and enhancing the work of antioxidants. Without it, teeth decay and chronic pain worsens. The mineral is especially useful for asthmatics and can prevent gastrointestinal cancer. Molybdenum enhances the sexual function of men and removes toxic substances from the body.

Phosphorus

Phosphorus obtained from food is generally only 70% absorbed by the body. It ensures strong teeth, improves metabolism and cell division. Without it, the acid-base balance and enzyme reactions are disrupted. A sufficient amount of phosphorus reduces pain in arthritis.

All tablets contain excipients such as sucrose, lactose, orange and castor oil, paraffin, dyes, and other components. Before purchasing and taking Duovit vitamins, you should carefully read the instructions to prevent side effects.

Duovit instructions for use

Indications for the use of color-coated tablets may be as follows:

• constant mental and physical stress;
• bad habits associated with smoking, regular drinking of alcohol;
• seasonal shortage of fresh herbs, fruits and vegetables;
• irregular and poor nutrition;
• strict diet for weight loss;
• significant loss of minerals and vitamins as a result of prolonged menstruation, poisoning accompanied by diarrhea and vomiting, bleeding;
• active and frequent sports.

There is also. The difference between the types is the composition: the tablets contain more or less amounts of certain substances, the amount of which is directly related to the needs of both sexes for useful substances.

Not only adults, but also children over 10 years old can take Duovit (the one intended for both sexes). According to instructions, once a day we drink one red and one blue jelly bean. Drug used after breakfast, the tablets should be swallowed whole with plenty of water.

Duovit cannot be taken together with other vitamin forms. If there is a need to resort to the parallel use of drugs containing any mineral or vitamin with Duovit, then they should be taken separately, only as prescribed by a doctor.

When taking any vitamins or medications, you should carefully monitor your condition and consult a doctor if:

• increased sensitivity to components;
• signs appeared.

Drinking Duovit is strictly prohibited for people suffering from thrombophlebitis, gout, peptic ulcers, hypercalcemia, sarcoidosis, chronic heart failure and other diseases, a full list of which is contained in the instructions attached to the drug. The presence of auxiliary components such as glucose, sucrose, lactose and sorbitol makes the drug inaccessible to people suffering from fructose intolerance and diabetes. Use of any form of vitamin E and C is contraindicated when taking certain medications.

In order for taking Duovit vitamins, as well as other similar drugs, to bring the expected benefits and not harm your health, it is advisable to use it after the recommendation of a doctor and reading the instructions.

Tradename

International nonproprietary name

Dosage form

Compound

One red pellet contains

Excipients: lactose monohydrate, orange oil 05073,

polysorbate 80, glycerin, castor oil (cold pressed), sorbitol,

liquid glucose (dry matter), antifoaming agent 1510, magnesium stearate, *Opalux AS-F-2833 G (E 124 + E 110), capol 600 pharma, sucrose.

One blue pellet contains

Excipients: lactose monohydrate, orange oil 05073, polysorbate 80, glycerin, castor oil (cold pressed), sorbitol, liquid glucose (dry matter), antifoaming agent 1510, magnesium stearate, liquid paraffin, povidone, **Opalux AS-20912 blue (E 132), capol 600 pharma, sucrose.

*Composition of the shell of Opalux AS-F-2833 G (E 124 + E 110): sucrose, purified water, ponceau 4R lake, titanium dioxide, Fd&C yellow #6/sunset yellow FCF aluminum lake, povidone, sodium benzoate

**Composition of the shell of Opalux AS-20912 blue (E 132): sucrose, titanium dioxide, purified water, Fd&C blue #2/indigo carmine aluminum lake, povidone, sodium benzoate.

Description

Hard smooth dragees covered with a red shell with a sweet and sour taste (vitamins) and hard smooth dragees coated with a blue shell (minerals)

Pharmacotherapeutic group

Multivitamins in combination with other drugs. Multivitamins with other minerals.

ATX code A11AA03

Pharmacological properties

Pharmacokinetics

There are no data available for Duovit ® , tablets. However, the absorption, distribution and elimination of individual vitamins and minerals are well known and described in the literature.

Water-soluble vitamins (B vitamins, vitamin C and biotin) are very well absorbed within the daily requirement. The amount of excess tissue saturation is excreted in urine, and in some cases in feces. Vitamins are in limited quantities in the body, so they must be consumed regularly to maintain their concentration in tissues.

Fat-soluble vitamins A and D, after oral administration, are well absorbed in the small intestine in the presence of fat. Vitamin E absorption is relatively low (from 25 to 85% of the dose). These vitamins are found in large quantities in the liver in the body, so they are more toxic than water-soluble vitamins.

The effect of the drug Duovit ® is the combined effect of its components, so kinetic observations are not possible; Collectively, the components cannot be traced using markers or bioassays.

Pharmacodynamics

Duovit ® contains vitamins and minerals. Vitamins and minerals are closely related in their activity and additive effectiveness. Often, vitamins and minerals cannot be in the same composition; therefore, they are separated in Duovit ®: the red dragee contains vitamins and the blue dragee contains minerals. Duovit ® tablets replenish the body's need for vitamins and minerals and prevent their deficiency.

Vitamins are biologically active substances that take part in many biochemical processes in the body.

B vitamins (B 1, B 2, B 6, pantothenic acid and nicotinamide) take part in the metabolism of carbohydrates, fats and proteins, as well as in the activity of the nervous system. Vitamin A is necessary for the development of epithelial cells and the synthesis of visual pigment. Vitamin D regulates the utilization of calcium and promotes the mineralization of bones and teeth. Vitamin C increases iron absorption and is involved in many redox processes in the body. Vitamin E is a physiological antioxidant that protects membrane walls from damage and maintains their functional activity.

Minerals and oligoelements extremely important for the body. They are included as components of supporting tissues or as activators and components of enzymes and hormones. Calcium and phosphorus play a key role in the mineralization of bones and teeth. Calcium ions activate numerous enzymes, take part in regulating the tone of the heart muscle, transmitting nerve impulses, and regulating the permeability of cell membranes. B vitamins, iron and copper are the most important elements for the formation of red blood cells. Magnesium, manganese, zinc and molybdenum, as constituent components of enzymes, participate in reactions important for the body.

Indications for use

Duovit ® is used as a prophylactic agent for conditions accompanied by an increased need for vitamins and minerals:

Increased physical and neuropsychic stress

Active sports

Pregnancy and lactation

Irregular, poor nutrition or monotonous diet

Insufficient conversion of food (in elderly people, smokers and alcohol abusers)

Improper diet (mainly fast foods,

dry, when eating in public canteens)

Restricted diet (weight loss, diabetes, etc.)

During periods of shortage of fresh vegetables and fruits

The recovery period after illnesses

Chemotherapy (as part of complex therapy)

With increased loss of minerals (vomiting, diarrhea, intense

menstruation, increased sweating)

Directions for use and doses

The pills should be swallowed whole with a small amount of water.

The course of treatment is up to 1 month. Subsequent treatment is possible after a break (from 1 to 3 months) or on the recommendation of a doctor.

Side effects

Very rarely(<1/10,000):

Hypersensitivity

-Rarely(≥1/10,000 to<1/1,000):

Disorders of the gastrointestinal tract, if the pill

taken on an empty stomach

Contraindications

Hypersensitivity to any of the components of the drug

Hypervitaminosis A and D

Kidney failure

Children and teenagers up to 18 years of age.

Drug interactions

The drug is not recommended to be taken simultaneously with tetracycline antibiotics and antacids. Absorption of minerals and tetracyclines is reduced due to their simultaneous administration. Some antacids reduce the absorption of minerals. If treatment involves the simultaneous use of such drugs, it is necessary to maintain an interval between taking Duovit ® and tetracycline antibiotics/antacids for at least 3 months.

special instructions

Duovit ® must be taken after meals to avoid discomfort in the stomach.

Patients suffering from diabetes can take Duovit ®, but it must be remembered that the daily dose contains 1.6 g of sugar. Each dragee contains about 0.8 g of sugar.

You should consult your doctor or pharmacist regarding simultaneous use with other vitamins, vitamin-mineral and/or mineral complexes.

Special instructions and precautions regarding excipients

Duovit ® contains lactose, sorbitol, glucose and sucrose. The drug is not recommended for patients with hereditary diseases of glucose or galactose intolerance, Lapp-lactase deficiency or glucose-galactose malabsorption or sucrose-isomaltase deficiency. Dyes E124 and E110 can cause an allergic reaction.

Features of the influence on the ability to drive a vehicle or potentially dangerous mechanisms.

The drug does not affect the ability to drive vehicles and other mechanisms.

Overdose

Symptoms: weakness, anorexia, nausea, vomiting, diarrhea, weight loss, fever and convulsions (symptoms of hypervitaminosis A, which are likely with long-term use of very large doses), headache, dizziness, sleep disturbance, nausea, vomiting, drowsiness, photophobia and convulsions (symptoms hypervitaminosis D, which are likely with long-term use of very large doses)

Treatment: activated carbon, gastric lavage; If necessary, carry out symptomatic therapy.

Release form and packaging

10 tablets each (5 tablets with red vitamins and 5 tablets with blue minerals) are placed in a blister pack made of polyvinyl chloride/polyvinyl dichloride film and aluminum foil.

4 blister packs together with instructions for medical use in the state and Russian languages ​​are placed in a cardboard pack.

Storage conditions

Store in original packaging at a temperature not exceeding 25 ºС, in a dry place, protected from light.

Shelf life

Do not use after expiration date.

Conditions for dispensing from pharmacies

Over the counter

Manufacturer

KRKA, d.d., Novo Mesto, Slovenia

Name and country of the marketing authorization holder

KRKA, d.d., Novo Mesto, Slovenia

Address of the organization that accepts claims from consumers regarding the quality of products (products) on the territory of the Republic of Kazakhstan

Representative office of “KRKA, tovarna zdravil, d.d., Novo mesto” in the Republic of Kazakhstan

) – 1 mg;

One blue dragee contains:

• calcium hydrogen phosphate dihydrate – 64.5 mg (this corresponds to 15 mg calcium and 12 mg phosphorus );
• Magnesium lactate dihydrate – 200 mg (this corresponds to 20 mg magnesium );
• ferrous fumarate – 30.3 mg (this corresponds to 10 mg gland );
• copper sulfate pentahydrate – 4 mg (this corresponds to 1 mg copper );
• heptahydrate – 13.3 mg (this corresponds to 3 mg zinc );
• manganese sulfate monohydrate – 3.1 mg (this corresponds to 1 mg manganese );
• sodium molybdate dihydrate – 220 mcg (this corresponds to 100 mcg molybdenum ).

Excipients: lactose monohydrate, polysorbate 80, orange oil, , castor oil, liquid , povidone, defoamer 1510, sorbitol, magnesium stearate, liquid paraffin, dyes (Opalux, indigo carmine Blue and sunset yellow), emulsion wax, sucrose.

Release form

Available in the form of dragees, 10 pieces (5 red dragees and 5 blue dragees) in a blister, four such blisters in a paper package.

pharmachologic effect

Replenishing the deficiency of microelements and vitamins.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Group vitamins IN involved in the metabolism of proteins, carbohydrates and fats, indispensable for the proper functioning of the nervous system. indispensable for the development of epithelial cells and for the production of visual pigment. responsible for absorption calcium and mineralization of bone tissue. responsible for absorption gland and is a necessary component of redox reactions in the body. – a powerful antioxidant and membrane protector.

Oligoelements and minerals are also extremely important. Ions calcium participate in the regulation of cardiac muscle tone and in the processes of occurrence of nerve impulses. A phosphorus And calcium necessary elements of bones and teeth. Copper And iron structural components of red blood cells. Magnesium, zinc, manganese And molybdenum - components of a number of important enzymes.

Pharmacokinetics

Water-soluble vitamins (groups B , ascorbic acid And biotin ) are perfectly absorbed within the daily requirement. The remaining amount is excreted in urine and feces.

After taking lipophilic vitamins A And D absorbed in the presence of fats in the small intestine. Absorption alpha tocopherol ranges from 25% to 80% of the dose taken. These vitamins accumulate in significant quantities in the liver, making them potentially toxic.

Indications for use

• active recreation and sports;
• mental and physical overload;
• poor nutrition (elderly people, smokers, alcoholics);
• unbalanced diet (dry food, fast food);
• diets for weight loss;
• seasonal lack of vegetables and fruits in the diet;
• severe loss of minerals (excessive menstruation, vomiting, increased sweating).

Contraindications

• to the components of the drug, hypervitaminosis A, E or D , kidney failure.
• Nephrolithiasis, hyperuricemia, , erythrocytosis, erythremia, fructose intolerance, thromboembolism , glucose-galactose malabsorption syndrome, metabolic disorder copper or gland , chronic, history, hypercalciuria, hypercalcemia, stomach or duodenum , in active form.
• Age less than 10 years.

Side effects

• From the immune system: including, bronchospasm .
• Metabolism: hypercalcemia .
• From the nervous system: , .
• From the point of view: visual disturbances.
• From the digestive system: nausea, vomiting, abdominal pain, increased acidity.
• From the skin: , rash, hyperemia skin.
• From the excretory system: hypercalciuria.
• General violations: hyperthermia , .

With long-term use in large doses, the following occur: hyperuricemia, hyperglycemia, irritation of the mucous membrane of the digestive tract, dry palms and soles, seborrheic rash , kidney damage, temporary increase in concentration LDH, AST, alkaline phosphatase .

Instructions for use of Duovit

This section indicates how to take Duovit correctly. If you take vitamins as prescribed below, they will not cause any unwanted effects.

For children over 10 years old and adults – 1 red pellet and 1 blue pellet per day. The course of therapy is 20 days (can be repeated on the recommendation of the attending physician).

Overdose

Symptoms: headache, hypervitaminosis D And A , vomit, .

There have been no reports of overdose when using the drug in recommended quantities.

Interaction

Duovit should not be used simultaneously with tetracyclines And antacids , as there may be a decrease in absorption and minerals. If therapy requires the combined use of these drugs, then the time interval between doses should be at least three hours.

Due to the possible occurrence hypervitaminosis A simultaneous use of Duovit with products containing is not recommended.

Use should be avoided by persons using oral anticoagulants , as the likelihood of bleeding increases.

During the treatment period sulfonamides To prevent the development of crystalluria, it is recommended to avoid excessive amounts.

Persons with need to know that one tablet contains about 800 mg Sahara.

Blue and red dragees contain 1084 mg sucrose , 330 mg lactose , 238 mg sorbitol , 270 mg glucose , therefore Duovit is not recommended for people with congenital fructose intolerance or glucose , With glucose syndrome or galactose malabsorption And isomaltase deficiency or sucrase .

Azo dyes E110 And E124 capable of causing