Is it possible to take Kestin with alcohol? Kestin fast dissolution. Form, composition, packaging

Alcohol and antihistamines are incompatible. During the period of fighting the disease, it is necessary to abstain from alcoholic beverages to avoid dangerous side effects.

Mechanism of action of antiallergenic

Antihistamines are used to treat allergic conditions. These drugs block histamine H1 receptors, thereby suppressing the action of histamine, which is the main mediator of most allergic manifestations. In addition, they have sedative and hypnotic effects, and body temperature decreases.

Common drugs

1st generation drugs:

• Diphenhydramine;
• Diazolin;
• Suprastin;
• Tavegil;
• Fenkarol.

Can I take it at the same time? Why is this dangerous?

It is an indication for the use of antihistamines.

2nd generation drugs:

• Claridol;
• Clarotadine;
• Lomilan;
• Loragexal;
• Claritin;
• Rupafin;
• Zyrtec;
• Kestin.

3rd generation drugs:

• Gismanal;
• Trexil;
• Telfast;
• Fexadine;
• Fexofast;
• Levocetirizine-Teva;
• Xizal;
• Erius;
• Desal.

Is it possible to combine

It is not advisable to take antihistamines and alcohol at the same time. The consequences of mixing these drugs and alcoholic beverages depend on the type of medication. First generation drugs are most dangerous when mixed with alcohol.

This is especially true for taking large doses of alcohol. But drinking in moderation, about 30 ml of ethanol per day, will not lead to strong negative consequences. It must be borne in mind that in each case the disease and the body are special. And in this regard, it is necessary to consult with your doctor.

Possible consequences

As a result of simultaneous use with alcohol, antiallergic drugs enhance the effect of alcohol on the body and cause a negative reaction.

There is a high risk of fainting and even coma, given that alcohol has a sedative effect on the brain.

Under the influence of alcohol, the hepatotoxic effect of antihistamine on the liver increases. The work of the liver enzyme aldehyde dehydrogenase is disrupted, and the organ is poisoned by decay products. This can lead to drug-induced hepatitis.

When drinking alcohol while taking pills, ethanol reduces the effectiveness of medications, being itself an allergen. In case of intolerance to ethyl alcohol, the digestive system cannot cope with the incoming alcohol, and acetaldehyde accumulates in the body. This causes alcohol allergies.

There is a high probability that alcohol will change the properties of the medicine and the body’s reaction will be unpredictable. There may be disturbances in the functioning of the heart, disturbances in the heart rhythm in the form of rapid heartbeat, a sharp increase in blood pressure, up to a hypertensive crisis.

The incompatibility of antihistamine and ethyl alcohol increases the effect of the drug on the central nervous system and can lead to a state of motor overexcitation or severe inhibition, and there is a risk of hallucinations. There may be an increase in negative reactions observed after drinking alcoholic beverages, including hangover syndrome.

Composition and alcohol

In this article you can read the instructions for use of the drug Kestin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Kestin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Kestin analogues in the presence of existing structural analogues. Use for the treatment of urticaria, rhinitis and other manifestations of allergies in adults, children, as well as during pregnancy and breastfeeding. Composition and interaction of the drug with alcohol.

Kestin is an antiallergic drug. After taking the drug orally, a pronounced antiallergic effect begins within 1 hour and lasts for 48 hours. After a 5-day course of treatment with Kestin, antihistamine activity persists for 72 hours due to the action of active metabolites. The drug does not have a pronounced anticholinergic and sedative effect. There was no effect of the drug Kestin on the QT interval of the ECG at a dose of 100 mg, which exceeds the recommended daily dose by 5-10 times.

Ebastine + excipients.

After oral administration, it is quickly absorbed and almost completely metabolized in the liver, turning into the active metabolite carabastine. Fatty foods accelerate absorption (concentration in the blood increases to 50%). Eating does not affect the clinical effects of Kestin. Does not penetrate the blood-brain barrier. Excreted by the kidneys, in the form of conjugates.

• allergic rhinitis, seasonal and/or year-round (caused by household, pollen, epidermal, food, drug allergens);
• urticaria (can be caused by household, pollen, epidermal, food, insect, drug allergens, exposure to the sun, cold, etc.);
• allergic diseases and conditions caused by increased release of histamine.

Film-coated tablets 10 mg and 20 mg.

Lyophilized tablets 20 mg.

Syrup (sometimes mistakenly called drops).

Instructions for use and dosage regimen

Inside, regardless of food intake.

Adults and children over 12 years of age are prescribed mg (1-2 tablets) of the drug once a day.

If liver function is impaired, the daily dose should not exceed 10 mg.

Adults, children and adolescents over 15 years of age are prescribed 20 mg (1 lyophilized tablet) 1 time per day. The course of treatment is determined by the disappearance of symptoms of the disease.

Special precautions when handling the drug:

1. Remove the protective film.

• Children from 6 to 12 years: 5 mg (5 ml) 1 time per day.
• Children from 12 to 15 years: 10 mg (10 ml) 1 time per day.
• Adults and children over 15 years of age are prescribed mg (10-20 ml) once a day.

Kestin is taken regardless of meals.

• headache;
• drowsiness;
• dryness of the oral mucosa;
• dyspepsia;
• nausea;
• insomnia;
• abdominal pain;
• asthenic syndrome;
• sinusitis;
• rhinitis.

• hypersensitivity to the components of the drug;
• pregnancy, lactation period;
• children up to 12 years of age (tablets), up to 15 years of age (lyophilized tablets);
• lactase deficiency
• lactose intolerance
• glucose-galactose malabsorption.

Use during pregnancy and breastfeeding

Kestin is contraindicated during pregnancy and lactation.

Tablets are contraindicated in children under 12 years of age. Lyophilized tablets are contraindicated in children under 15 years of age. The syrup is used with caution in children under 6 years of age.

Use with caution in patients with an increased QT interval, hypokalemia, and renal and/or liver failure.

Impact on the ability to drive vehicles and operate machinery

In the event of side effects from the central nervous system, there may be a minimal decrease in the ability of patients to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

The drug Kestin does not interact with theophylline, indirect anticoagulants, cimetidine, diazepam, ethanol (alcohol) and ethanol-containing drugs.

Analogues of the drug Kestin

The drug Kestin has no structural analogues for the active substance. The drug contains the unique active ingredient Ebastine.

Analogs for therapeutic effect (medicines for the treatment of urticaria):

Kestin is an effective remedy for combating allergies

Kestin is an antiallergic drug from the group of new generation long-acting antihistamines. It blocks the occurrence of smooth muscle spasms and increased vascular permeability caused by the action of histamine.

The active ingredient is ebastine. The drug is presented in two forms: syrup and film-coated tablets. The medicine is quickly absorbed, so the pronounced antiallergic effect of Kestin begins to appear 60 minutes after taking it and lasts for 48 hours.

The drug is metabolized in the liver and converted to carebastine (the active metabolite). If the medication is taken for more than 5 days, due to carebastine, the antihistamine effect can last for 72 hours. Due to this property, with long-term use of the drug, it is possible to prescribe kestin for five days with a break of two days.

Indications for the use of kestin are hay fever, manifested by allergic rhinitis and conjunctivitis, allergic dermatitis, idiopathic chronic urticaria, as well as urticaria of any origin.

The daily dose of the drug for adults and children over 12 years of age is 10–20 mg. The exception is the presence of liver diseases accompanied by a violation of its functions. In such cases, the dosage should not exceed more than 10 mg per day. Taking kestin is not associated with food intake and time of day.

Side effects may occur in the form of headache, insomnia, drowsiness, dry mouth, nausea, heartburn, abdominal pain, and diarrhea. Individual intolerance to the drug occurs.

Taking kestin is contraindicated during pregnancy, in the postpartum period during lactation, with phenylketonuria, hypokalemia, renal and liver failure. individual intolerance to the drug, as well as use in children under 12 years of age.

To avoid unwanted reactions of the body to the drug, you should carefully read the instructions for use of Kestin. In case of overdose or pronounced side effects, gastric lavage and symptomatic therapy are recommended.

Kestin, when observed in therapeutic dosages, has no effect on driving and is compatible with alcohol. By following all the rules and recommendations for use, you can expect a positive medicinal effect.

Kestin (Tablets 10 mg) instructions for use

composition, action, pharmacological properties, indications for use, contraindications, method of administration, doses, side effects, overdose.

Composition and release form of the drug kestin

Kestin is a synthetic drug. The active ingredient is ebastine. They produce film-coated tablets (1 tablet contains 10 mg of ebastine) - 10 pcs. packaged.

Medicinal properties

Kestin has antiallergic and antihistamine effects. Reduces the severity of skin manifestations of allergic reactions, does not have pronounced anticholinergic and sedative activity.

Indications for use

Allergic rhinitis (seasonal, year-round); - idiopathic chronic urticaria.

Rules of application

Kestin tablets should be taken regardless of meals. For adults with allergic rhinitis - mg (depending on the severity of symptoms), for idiopathic chronic urticaria - 10 mg 1 time per day.

Side effects

Headache; - drowsiness; - dry mouth. Rarely: - abdominal pain; - dyspepsia; - nausea; - asthenia; - insomnia; - rhinitis; - sinusitis.

Contraindications

Hypersensitivity to the drug kestin; - age up to 12 years (the safety and effectiveness of the drug kestin in children has not been studied).

Pregnancy and lactation

The safety of using the drug kestin in pregnant and lactating women has not been studied.

Interaction with alcohol

The drug is compatible with ethanol and ethanol-containing drugs.

special instructions

Kestin should be administered with caution to patients with renal or hepatic impairment. It is not recommended to combine with erythromycin, ketoconazole. Does not reduce the ability to drive a car or operate machinery.

Storage conditions

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kestin and alcohol

In the section Diseases, Medicines, to the question: Can I drink alcohol after taking the allergy pill “Kestin”? asked by the author Dasha Naumova the best answer is Hmm... You should not drink alcoholic beverages, as the toxic effect on the body increases. This is generally a dangerous combination. Alcohol enhances the depressive effects of antihistamines on the central nervous system. The consequences can be the most unexpected.

don't poison your liver

Can. but this can cause some kind of reaction, as well as the inactivity of the device further) I had this happen with suprastin, now it doesn’t work on me

Alcohol should not be used with more than one medicine! Everyone's reaction is different!

Kestin - methods of use and dosage, how effective the treatment is, reviews

Today we will talk about Kestin, as one of the effective remedies for allergies. Or not effective? Let's figure it out.

Allergic diseases are currently observed in one form or another in a larger number of people on the planet.

Developing allergies significantly change a person’s well-being for the worse and negatively affect their ability to work and the acquisition of new knowledge.

Some complications of allergies are also dangerous for people, and therefore treatment of symptoms of intolerance to a certain irritant that arise constantly or periodically is always necessary.

The pharmacological industry is constantly developing and producing new antihistamine drugs, the latest group of which includes the drug Kestin.

The positive properties of the antihistamine Kestin have been assessed by a fairly large number of people with allergic reactions, and this allows us to assert that the medicine has the desired therapeutic activity.

Kestin - composition of the drug and mechanism of action

Kestine is available in two forms - tablets and syrup.

The tablet form of the drug is intended for patients over 12 years of age.

Allergists recommend ALLERGONIX as an effective remedy for allergies. The product contains natural ingredients, living plant cells, and restores metabolic processes in the body. The drug underwent clinical tests for 8 years. ALL THE DETAILS HERE.

The syrup can be used to eliminate allergy symptoms in children starting from the age of six.

Tablets are available in two types, that is, they can be film-coated or lyophilized.

Lyophilized tablets quickly develop their healing properties and begin to work when exposed to moisture.

The main active ingredient of the drug is ebastine, which is a histamine H1 receptor blocker; there is a drug with the same name Ebastine, which is a complete analogue of Kestin.

Any allergic reaction in the body occurs with the formation of inflammatory mediators, which primarily include histamine.

Under the influence of this substance, all the signs of an allergic reaction develop, that is, tissue swelling occurs, the production of mucous secretion by cells increases, irritation and itching appear.

In order to achieve the disappearance of these symptoms, it is necessary to interrupt the production of inflammatory mediators, and antihistamines, according to their mechanism of action, are designed precisely for this.

Ebastine, which is part of Kestin, has pronounced antihistamine activity, its full effect occurs within one hour after administration.

The general course of treatment is determined by the cessation of signs of an allergic reaction.

In the treatment of some patients, a four-week course of therapy with this drug was prescribed and no significant side effects were noted.

How does Kestin differ from other antihistamines?

Currently, many different drugs are produced aimed at eliminating allergies or preventing them.

It is quite difficult to select the most effective one and this can only be done correctly under the guidance of a doctor after completing all the studies.

The medicine Kestin must also be prescribed for use by an allergist and, first of all, it is prescribed for the treatment of:

• Year-round or seasonal rhinitis that occurs under the influence of different groups of allergens;
• Allergic conjunctivitis;
• For Quincke's edema and urticaria. Allergic disease caused by physical factors, that is, direct sunlight, cold, overheating, can also be treated;
• Any diseases that develop under the influence of histamine produced in the body.

Taking Kestin provides a rapid therapeutic effect; a noticeable reduction in symptoms is observed within one hour after taking the required therapeutic dose.

The medicine Kestin has a number of additional advantages:

• The drug can be taken once a day, its therapeutic effect lasts for 48 hours;
• For long-term treatment with Kestin, an intermittent treatment regimen is used. The medicine must be taken daily in the required dosage for 5 days, then take a break for two days. This use became possible due to the fact that with long-term use, ebastine accumulates in the body and then its therapeutic, antihistamine effect is expressed within 72 hours;
• There is no need to take the medicine with water; the tablet dissolves easily and quickly in the mouth under the influence of salivary enzymes. Due to this, Kestin is convenient to use while traveling;
• The drug does not affect the reaction rate and therefore treatment with it is possible when driving vehicles and other complex mechanisms.

When prescribing a medicine, the doctor must take into account the patient's use of other medications and select a treatment regimen accordingly.

How to use Kestin

Kestin can be used for medicinal purposes regardless of food intake; the medicine does not need to be washed down with water.

When opening the package, you must be careful, as the tablets are quite fragile and easily break under pressure.

Treatment begins with a dose of 10 mg; if the desired effect is not observed, then the dosage is increased to 20 mg per day.

Children from 12 to 15 years of age are treated only with a dose of 10 mg per day. The same dosage should be observed in patients with severe liver dysfunction.

In other cases, the drug is taken according to the usual regimen. It should also be taken into account that the use of Kestin is contraindicated in some cases.

The medicine is not prescribed:

• Pregnant women and women breastfeeding. Clinical trials of this group of patients have not been conducted, and therefore doctors cannot say with certainty how ebastine will affect the development of the fetus;
• The drug in tablets is not used until the child reaches the age of twelve.

In rare cases, patients experience headache, slight dizziness, dyspepsia, abdominal pain, drowsiness, or, conversely, insomnia.

If these changes are very disturbing and do not go away within a few days, the doctor may reduce the daily dose.

An overdose of the drug is reflected in changes in the functioning of the central nervous system; severe symptoms of poisoning occur when using Kestin in a dose of 300 mg, which is almost 15 times higher than a single dose.

There is no antidote for the drug, so in case of overdose, symptomatic therapy is used.

If you accidentally take several antihistamine tablets at once, you must rinse your stomach as quickly as possible.

Kestin and other groups of drugs

The antihistamine drug Kestin, produced in the form of film tablets, is incompatible:

• With antifungal medications such as Fluconazole, Ketoconazole;
• Antibiotics from the Macrolide group;
• With a drug used in the treatment of asthma – Theophylline;
• Indirect anticoagulants;
• With the antiulcer drug Cimetidine;
• With the drug Diazepam;
• With medications manufactured using ethanol.

Lyophilized tablets are not prescribed simultaneously with Ketoconazole and Erythromycin, but can be used with those medications for which the use of film-coated tablets is contraindicated.

Lyophilized Kestin can also be consumed with moderate doses of alcohol.

When prescribing medication, the allergist must know what else his patient is being treated with. This will avoid unwanted reactions and increase the likelihood of the prescribed therapy being effective.

The drug is freely available in pharmacies; it can be stored under normal conditions, when the room temperature does not exceed 25 degrees.

Basic and frequently used analogues of Kestin

In cases where Kestin is contraindicated for any indication or when undesirable reactions occur during use, the doctor selects analogues, that is, drugs that have a similar mechanism of action.

The main analogues of Kestin include:

• H1-histamine receptor blockers based on other active ingredients. These are drugs such as Fenistil, Diazolin, Diprazin, Semprex, Zodak, Loratadine, Astelong, Supradin;
• Mast cell membrane stabilizers - Intal, Lecrolin, Nedocromil Sodium. This group of drugs prevents the release of histamine and other mediators of allergic inflammation from mast cells.

Only a doctor should select analogues, just like Kestin himself.

Self-prescription almost never eliminates all manifestations of allergies and, moreover, can be complicated by other pathologies.

Reviews about Kestin

“For the second year now, I’ve been taking Kestin with me on vacation to the village, where I like to walk through the forest. But, unfortunately, many plants have given me a runny nose before. With the start of using Kestin, this problem went away. The drug quickly dissolves in the mouth and sneezing and mucus disappears in literally two hours” - Marina, 43 years old.

“Kestin was prescribed to my son for the last time as part of a comprehensive treatment by our allergist. A week after treatment, we noticed that the asthma attack provoked by wormwood flowering was not so severe and stopped quickly. I think that this is still a positive influence of Kestin” - Olga, 37 years old.

“The doctor prescribed Kestin syrup to my 8-year-old son for itchy dermatosis. To be honest, we didn’t feel any effect. The condition began to stabilize only after taking another antiallergic drug” - Natalya, 38 years old.

To the question whether the drug Kestin is effective or not, we answered, of course YES.

But before taking this medicine, be sure to consult your doctor. Since Kestin’s incompatibility with some drugs can harm your body.

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Kestin /

Powerful, but not perfect...

Kestin: stands out, even from its 4th generation counterparts

The instructions say that kestin helps with allergic rhinitis, which is caused by dust, flowers, etc., and with urticaria.

I know how to treat hives, I haven’t tried it, but for allergies to flowers

didn’t help me (I have hay fever - it’s an allergy to flowers

weeds, appears in mid-July and lasts until the end of August). So

no matter how long I took these pills, in different doses, it didn’t help,

The runny nose, sneezing, and itchy throat remained. This is a remedy for hay fever

not suitable for fever. Zertek is helping me. But more on that in another review.

I would also like to say that before you choose your medicine, go to

an allergist, where you will do tests for allergens and know exactly what

Kestin and alcohol compatibility

The drug Kestin Rapid Dissolution is an antiallergic drug, an antihistamine of the latest generation.

The active ingredient of the drug is ebastine.

The pronounced antiallergic effect of Kestin begins 1 hour after administration and continues for 48 hours. After a 5-day course of treatment with the drug, antihistamine activity persists for 72 hours due to the action of active metabolites. Therefore, with long-term use, you can use a convenient therapy regimen - 5 days on + 2 days off. Kestin is compatible with alcohol. The high effectiveness and safety of Kestin has been confirmed by numerous foreign and Russian post-registration clinical studies.

Indications for use:

The antiallergic drug Kestin Rapid Dissolution is indicated for allergic rhinitis of various etiologies (seasonal and/or year-round); urticaria of various etiologies, incl. chronic idiopathic.

The drug Kestin Rapid Dissolution is intended for resorption in the oral cavity, regardless of food intake.

In elderly patients, no dose adjustment is required.

In patients with impaired renal function, no dose adjustment is required.

For minor and moderate liver failure, the drug can be used in the usual dose. In case of severe liver dysfunction, the daily dose of ebastine should not exceed 10 mg.

Special precautions when handling the drug

To avoid damaging the tablets, do not remove the tablet from the blister by pressing. Open the package by carefully lifting the free edge of the protective film.

Remove the protective film.

Carefully squeeze out the drug without touching it.

Carefully remove the tablet and place it on your tongue, where it will quickly dissolve. There is no need to drink water or other liquid. Eating does not affect the effect of the drug.

When using Kestin Rapid Dissolution tablets, the following side effects are possible:

From the nervous system: from 1% to 3.7% - headache, drowsiness; less than 1% - insomnia,

From the digestive system: from 1% to 3.7% - dryness of the oral mucosa; less than 1% - dyspepsia, nausea, abdominal pain.

From the respiratory system: less than 1% - sinusitis, rhinitis.

Other: less than 1% - asthenic syndrome; allergic reactions are possible.

Contraindications to the use of the drug Kestin Rapid Dissolution are: phenylketonuria; pregnancy; lactation period (breastfeeding); children under 15 years of age; hypersensitivity to the components of the drug.

Use with caution in patients with prolonged QT interval, hypokalemia, and renal and/or liver failure.

The use of Kestin Rapid Dissolution is contraindicated during pregnancy and lactation (breastfeeding).

Interaction with other drugs:

Kestin lyophilized tablets 20 mg does not interact with theophylline, indirect anticoagulants, cimetidine, diazepam, ethanol and ethanol-containing drugs.

Symptoms of moderate effects on the central nervous system (fatigue) and autonomic nervous system (dry oral mucosa) can only occur with high doses (mg, which is several times higher than the therapeutic dose).

Kestin Fast Dissolution - lyophilized tablets; There are 10 tablets in a package.

1 tablet of Kestin Quick Dissolution contains: ebastine 20 mg.

Excipients: gelatin - 13.00 mg, mannitol - 9.76 mg, aspartame - 2.00 mg, mint flavor - 2.00 mg.

pharmachologic effect

Long-acting histamine H1 receptor blocker. Prevents histamine-induced spasms of smooth muscles and increased vascular permeability.

After taking the drug orally, a pronounced antiallergic effect begins within 1 hour and continues for 48 hours. After a 5-day course of treatment with Kestin ® lyophilized 20 mg tablets, antihistamine activity persists for 72 hours due to the action of the active metabolite.

With long-term use, a high level of blockade of peripheral histamine H1 receptors is maintained without the development of tachyphylaxis. The drug does not have a pronounced anticholinergic and sedative effect.

There was no effect of the drug Kestin ® lyophilized tablets 20 mg on the QT interval of the ECG at a dose of 100 mg, which exceeds the recommended daily dose (20 mg) by 5 times.

Pharmacokinetics

After oral administration, it is quickly absorbed and almost completely metabolized in the liver, turning into the active metabolite carabastine. After a single dose of 20 mg of the drug, the maximum concentration of carabastine in the blood plasma is reached after 1-3 hours and averages 157 ng/ml. Fatty foods accelerate the absorption of carabastine (blood concentration increases by 50%) and first-pass metabolism (formation of carabastine).

When taking the drug daily, the equilibrium concentration is reached after 3-5 days and is ng/ml. The binding of ebastine and carabastine to plasma proteins is more than 95%.

T1/2 of carabastine ranges from 15 to 19 hours. 66% of the drug is excreted in the form of conjugates through the kidneys.

Pharmacokinetics in special clinical situations

In elderly patients, pharmacokinetic parameters do not change significantly.

In case of renal failure, T1/2 increases, and in case of liver failure - up to 27 hours, however, the concentration of the drug does not exceed therapeutic values.

Indications

Allergic rhinitis of various etiologies (seasonal and/or year-round);

Urticaria of various etiologies, incl. chronic idiopathic.

Dosage regimen

The drug is intended for absorption in the oral cavity, regardless of food intake.

Adults, children and adolescents over 15 years of age are prescribed 20 mg (1 lyophilized tablet) 1 time/day. The course of treatment is determined by the disappearance of symptoms of the disease.

In elderly patients, no dose adjustment is required.

In patients with impaired renal function, no dose adjustment is required.

For minor and moderate liver failure, the drug can be used in the usual dose. In case of severe liver dysfunction, the daily dose of ebastine should not exceed 10 mg.

Special precautions when handling the drug

1. To avoid damaging the tablets, do not remove the tablet from the blister by pressing. Open the package by carefully lifting the free edge of the protective film.

2. Remove the protective film.

3. Carefully squeeze out the drug without touching it.

Carefully remove the tablet and place it on your tongue where it will quickly dissolve. There is no need to drink water or other liquid. Eating does not affect the effect of the drug.

Side effect

From the nervous system: from 1% to 3.7% - headache, drowsiness; less than 1% - insomnia,

From the digestive system: from 1% to 3.7% - dryness of the oral mucosa; less than 1% - dyspepsia, nausea, abdominal pain.

From the respiratory system: less than 1% - sinusitis, rhinitis.

Other: less than 1% - asthenic syndrome; allergic reactions are possible.

Contraindications

Lactation period (breastfeeding):

Children under 15 years of age;

Hypersensitivity to the components of the drug.

WITH caution used in patients with prolonged QT interval, hypokalemia, and renal and/or liver failure.

Pregnancy and lactation

The use of the drug is contraindicated during pregnancy and lactation (breastfeeding).

special instructions

Ebastine may interfere with allergy skin test results. Therefore, it is recommended to carry out such tests no earlier than 5-7 days after discontinuation of the drug.

Impact on the ability to drive vehicles and operate machinery

In the event of side effects from the central nervous system, a minimal decrease in the ability of patients to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions is possible.

Overdose

Symptoms moderate effects on the central nervous system (fatigue) and the autonomic nervous system (dry oral mucosa) can only occur with high doses (mg, which is several times higher than the therapeutic dose).

Drug interactions

Kestin ® lyophilized tablets 20 mg does not interact with theophylline, indirect anticoagulants, cimetidine, diazepam, ethanol and ethanol-containing drugs.

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 3 years.

Kestine is a new generation antiallergic drug. After oral administration, a pronounced antiallergic effect begins 1 hour after ingestion and lasts more than 24 hours. After 5 days of taking Kestin, the antihistamine activity persists for 72 hours due to the action of active metabolites, therefore, with long-term use, you can use the regimen - 5 days on + 2 days off.

Does not cause drowsiness, compatible with alcohol. There was no effect of Kestin on the QT interval of the ECG even at a dose of 80 mg.

Allergic rhinitis, seasonal and/or year-round (caused by household, pollen, epidermal, food, medicinal and other allergens);

Urticaria (can be caused by household, pollen, epidermal, food, insect, drug allergens, exposure to the sun, cold, etc.);

Allergic diseases and conditions caused by increased release of histamine.

Composition: 1 tablet contains the active substance - 10 mg of micronized ebastine.

Excipients: microcrystalline cellulose, lactose monohydrate, corn starch, croscarmellose sodium, magnesium stearate, hypromellose, macrogol 6000, titanium dioxide (E171).

Directions for use and dosage: The drug is administered orally with water, regardless of food intake.

Adults and children over 12 years of age are prescribed 10 mg (1 tablet) of the drug per day.

A daily dose of 20 mg (2*10 mg) is prescribed on the recommendation of a doctor for severe symptoms.

If you forget to take a Kestin tablet, do not take a double dose at your next dose to make up for the missed dose. The daily dose should not exceed 20 mg.

Lactation period (breastfeeding);

Children's age: up to 12 years;

Hypersensitivity to the components of the drug.

Caution should be used when prescribing the medicine for renal and/or liver failure.

Side effects: Headache, dry mouth. In rare cases - dyspepsia, nausea, insomnia, drowsiness, abdominal pain, asthenic syndrome, sinusitis.

Storage conditions: Store at room temperature (15° to 25°C) out of the reach of children.

Kestin does not interact with theophylline, indirect anticoagulants, cimetidine, diazepam, ethanol and ethanol-containing drugs.

Manufacturer: Industrias Farmacéuticas Almirall SL - Spain

Tablet release form

Kestin tablets instructions

The instructions are a mandatory inclusion in each package of the tablet drug Kestin. Her retelling presented below is accompanied by information about analogues, prices and reviews of the medicine.

Form, composition, packaging

The drug Kestin is produced in the form of tablets of various types:

• in a film shell;
• lyophilized tablet form.

Film-coated tablets are round in shape and white in color. On one side of the pill there is an engraving indicating the concentration of the active substance: E10 or E20. The tablets are placed in blisters of five or ten pieces, followed by packaging in cardboard packs.

The active substance of the drug is ebastine in a concentration of twenty or ten milligrams, supplemented with the required amount of magnesium stearate, macrogol 6000, microcrystalline cellulose, titanium dioxide, gelatinized corn starch, hypromellose, lactose monohydrate, crosscarmellose sodium.

The shell consists of some amounts of titanium dioxide, hydroxypromethylcellulose, polyethylene glycol 6000.

The lyophilized form of Kestin tablets contains twenty milligrams of the active substance ebastine per pill with the addition of aspartame, mint flavor, manitol and gelatin.

This type of tablet has a round shape and is made in white color. The drug is also packaged in blisters and each of them is sealed with a dozen tablets in a box of thick paper.

Storage period and conditions

Under appropriate storage conditions, Kestin tablets in any of their forms can be stored for up to three years. The optimal conditions for their maintenance are room temperature and the absence of humidity in a darkened room. It is equally important to limit children's access to the drug.

Pharmacology

The main pharmacological property of the drug is the prevention of an allergic reaction. As a result of a certain mechanism of action of the active substance of the drug, the effects that histamine can cause are prevented and weakened. A significant effect of ebastine is the creation of competition for histamine for the opportunity to interact with histamine H1 receptors in tissues and organs. As a result of ebastine’s ability to displace histamine, it has the ability to not only prevent, but also stop the manifestations of allergies or reduce the severity of its symptoms.

The drug Kestin, when taken orally, is capable of:

• to eliminate tissue swelling;
• reduction of exudative phenomena;
• prevention of bronchospasm;
• relief of burning and itching of the skin and mucous membranes.

Pharmacokinetics

Taking the drug leads to a rapid antiallergic effect. The effect of the tablet, occurring within 60 minutes after use, lasts up to two days.

The active substance of the drug is metabolized in the liver and undergoes gradual elimination from the body through the kidneys, which allows the tablets to prolong their therapeutic effect for another three days after stopping use.

Indications for use of Kestin tablets

• for conjunctivitis or runny nose of an allergic nature (seasonal or year-round), arising from any type of allergens;
• for any of the patient’s conditions and ailments that are caused by a high content of a substance called histamine;
• in the presence of Quincke's edema, urticaria.

Contraindications

Prescription of the drug is not considered:

• with a high degree of sensitivity of the patient to its composition;
• with detected phenylketonuria (lyophilized tablet form);
• for pregnant women and nursing mothers;
• in adolescence up to 15 years for a lyophilized drug and in children up to 12 years for film-coated tablets.

Impaired kidney/liver functionality, hypokalemia and coronary artery disease require the patient to be careful when taking the drug.

Kestin instructions for use

The coated drug is prescribed to be taken 1 time per day, regardless of food.

For adult patients and adolescents over 15 years of age, 20 milligrams are prescribed per dose.

Adolescent children (12-15 years old) are prescribed 10 milligrams/day.

Lyophilized tablets are taken by dissolving on the tongue. Eating does not affect the time it takes to take the medicine. There is no need to take this type of drug.

The dosage instructions are identical to film tablets.

During pregnancy

During pregnancy, Kestin is contraindicated.

Kestin for children

Children are not prescribed until they are 12 or 15 years old, depending on the tablet form.

Side effects

In general, this drug is well tolerated by patients. However, it is possible that some side effects may develop that occurred during observation of treatment with Kestin.

• Headache;
• low performance;
• state of drowsiness;
• general weakness;
• insomnia;
• manifestation of lethargy.

• Violation of the digestive process;
• feeling of dryness in the mouth;
• nausea;
• pain in the abdominal area.

Overdose

If you take too much of the medicine, all side effects will most likely worsen. In this situation, immediately rinse the stomach and take activated charcoal. In a difficult situation, you should seek medical help.

Drug interactions

The drug in the form of film-coated tablets cannot be combined with the following medications:

• with antifungal medications (ketoconazole, fluconazole);
• with any medications that contain alcohol;
• with macrolide antibiotics (clarithromycin, erythromycin);
• with tranquilizers (diazepam);
• with an anti-asthma drug (theophylline);
• with an anti-ulcer agent (cimetidine);
• with indirect anticoagulants.

Kestin lyophilized tablets should not be combined with the drugs ketocanozol and erythromycin. Combination with other medications has no such restrictions.

Additional instructions

The active substance of the drug has the ability to distort the results of skin allergy tests. For this reason, the study is not carried out earlier than a week after stopping taking Kestin tablets.

Driving a vehicle and carrying out activities that involve operating machinery is only possible if there are no side effects from the nervous system when taking the drug.

Kestin analogues

All drugs that can block histamine receptors and relieve allergy symptoms can be considered analogues of the drug. We can talk about Fenistil, Diphenhydramine, Diazolin, Suprastin, Tavegil, Zodak, Cetrine, Loratadine and many other antiallergic drugs.

Price for Kestin

Pharmacies provide average prices for the drug Kestin:

film-coated tablets:

• 20 mg/No. 10 from 395 to 480 rubles;
• 10 mg/No. 10 from 335 to 390 rubles;
• 10 mg/No. 5 from 185 to 215 rubles:

lozenges (lyophilized):

Who is prescribed statins?

The use of these drugs helps reduce cholesterol, excess amounts of which lead to various health problems. Treatment with statins reduces mortality rates from heart attacks and strokes.

The mechanism of action of the drugs is based on the suppression of cholesterol. First of all, these products should be in every first aid kit for patients with heart disease. Statins are prescribed to people with complicated hypertension who have had a heart attack or pre-heart attack.

When prescribing drugs to young women, the doctor should explain to patients about the possible consequences and warn about the need for contraception. In exceptional cases, the drug may be prescribed during pregnancy. In this case, the duration of pregnancy is taken into account, all risks are compared, as well as the benefits of using the products.

Limitation for use

Contraindications to taking the drug are:

• renal pathology;
• allergic reactions;
• liver dysfunction;
• thyroid problems;
• diabetes;
• pathologies of the endocrine system;
• diseases of the musculoskeletal system;
• lactation period;
• pregnancy - with caution.

One of the limitations is individual intolerance to the components of the drug. It is undesirable to use drugs for treatment of alcohol dependence and poisoning.

Despite the fact that one of the contraindications is kidney disease, some representatives of the statin group are able, on the contrary, to improve their function. This fact should be clarified with your doctor when prescribing medication.

During a treatment course using statins, it is necessary to undergo regular tests in order to judge the correctness of the prescribed dosage based on health conditions. In order for the test results to give an accurate picture of the problem, it is prohibited to drink alcoholic beverages or drink grapefruit juice the day before the test. In addition, it is not recommended to exercise or give intramuscular injections.

Mechanism of action

Statins are responsible for blocking cholesterol production. The human body produces lipids on its own. If their quantity exceeds the permissible dose, a person’s health deteriorates.

Modern statin drugs reduce the production of mevalonate, which precedes lipophilic alcohol. A lack of cholesterol appears, and the liver, sensing this, begins to actively produce proteins for the receptors. Negative fats formed in the blood are broken down by liver cells. Clinical studies have demonstrated a significant reduction in low-density lipoproteins. As a percentage, this figure reaches 50%.

The main feature of statins is their use throughout life. As soon as they help achieve the desired indicator, in no case should the drug be discontinued. Medicine is necessary to maintain normal condition. Refusal of it returns the cholesterol level to its previous level.

Side effects

Statins are relatively new drugs. But despite this, many studies have been conducted on their effectiveness, and possible side effects from their use have been studied in some detail. Negative reactions of the body:

• indigestion;
• abdominal pain;
• diarrhea;
• nausea;
• headache;
• insomnia;
• dizziness;
• general weakness;
• muscle spasms;
• muscle necrosis.

All of the above symptoms are extremely rare and indicate, rather, an incorrect approach to treatment or the choice of a specific drug.

Are statins completely safe?

A large number of laboratory studies have been carried out to study the pharmacological properties of the drugs. Their results provide clear evidence that statins are effective in reducing the risk of possible complications from serious diseases and extending the years of life of patients.

Studies have shown that drugs in this group have a weak medicinal effect on muscle tissue cells, which ensures safety for them.

At the moment, the effect of statins on pregnancy has already been fully studied. Taking the medication even in the first three months of pregnancy did not produce any adverse reactions. A predisposition to the development of intrauterine defects from the use of drugs has not been established. If we talk about which drugs are considered safe, then we can say that they are all. The basic rule is a competent approach to treatment and choice of remedy.

How do statins behave in combination with alcohol?

The combination of alcoholic beverages and drug treatment is unlikely to ever become the rule. These are mutually exclusive products. Such compatibility is not only undesirable, but can also cause serious health problems, including death. What was the reason for such an unequivocal ban, and how do statins and alcohol behave when used simultaneously?

Consuming alcohol together with medications may not have the best effect on the properties of the drugs, namely, it may:

• enhance the effect of the medicine;
• weaken the perception of the drug;
• treatment will have the opposite effect.

No specialist will give the patient an exact answer on how the medicine and the body will behave when consuming alcohol. Any complication depends on various factors:

• specificity of tablets;
• type of alcohol;
• dose of alcohol taken;
• individual characteristics of the body.

These factors are also the reason why not a single annotation for the medicine contains accurate data about the possibility of drinking alcohol and in what quantity. Moreover, in medicine there are simply no useful combinations of certain medications with alcohol. All possible consequences are considered potential risks.

Negative effects of alcohol:

• nauseating state;
• gagging, severe diarrhea;
• a sharp decrease in blood pressure;
• chills, trembling, convulsions;
• skin rashes;
• loss of potency;
• poor coordination;
• feeling of suffocation;
• cardiopalmus;
• respiratory arrest;
• death.

In any case, the choice remains with the patient, the main thing is that it is conscious. It is important to understand that it is impossible to predict how the body will behave when ethanol appears.

Controversial harm of alcohol

You can find many different opinions about the effect of alcohol on the therapeutic properties of statins. Some argue that the compatibility of statins and alcohol is excluded. And most people believe that taking medications is a direct contraindication for drinking alcohol.

In addition to opponents of alcohol, there are many people who are convinced of the dangers of statins. In their opinion, they contribute to the appearance of a disease such as pancreatitis.

There is no point in doubting the impossibility of combining alcoholic beverages during drug treatment. Drinking alcohol in itself does not lead to anything good, especially since it will definitely not improve your health. And if you add to this a significant dose of chemicals, then you can expect the most unpredictable consequences. That is, what you should be most afraid of is precisely this kind of uncertainty and ignorance of how to behave correctly in the event of a deterioration in your health. Some symptoms of toxic poisoning may appear completely unexpectedly and begin to progress quickly. In such a situation, a person may simply not have time to react correctly.

The biggest danger lies in individual intolerance to individual components of the drug, which the patient may not even be aware of.

Statins interact well with the human body, as evidenced by the extremely rare occurrence of adverse reactions. Therefore, in the case of alcohol, everything will depend on the body’s behavior towards the presence of ethanol in the blood.

Cause of complications

Statins have an important role - to cure the patient from problems of the cardiovascular system. The main function of human life is assigned to it. This once again confirms that you should not joke with drugs in this group. If complications affect this particular system, it poses a great danger, even leading to cardiac arrest.

Drinking alcohol can affect the effect of the medicine and the effectiveness of treatment in general. Some may think that this is not scary. In fact, for a patient with high cholesterol levels, not only will an ineffective remedy be useless, but it can also give the opposite result, worsening the patient’s condition.

True, statins, which are highly active, can cause great harm to health. Cholesterol is an element vital for normal life. Without it, cells would not be able to support the functioning of the entire body. You cannot self-medicate or prescribe a dose of the drug for treatment. This is the task of an experienced doctor who knows about all the features of the drug. Increasing the dosage will never lead to a speedy recovery.

What are the dangers of taking statins?

It has already been said that statins lead to lower cholesterol. Most medical experts agree that cholesterol is the main cause of cardiovascular disease, or rather, its elevated level. Therefore, no one will pay much attention to the low amount of this element. It is clear that doctors are aware of the consequences of long-term use of statin drugs. But ordinary people know little about this. The generally accepted opinion about the dangers of cholesterol makes itself felt. And few of them understand the true purpose of this element in the human body, how much it helps in many vital functions and processes.

A long course of treatment with statin drugs pleases patients during the first 2-3 weeks of use. If the course lasts longer, patients begin to feel unpleasant reactions in their body:

• accumulation of gases, bloating, colic;
• muscle weakness;
• febrile state, high temperature;
• decreased visual acuity;
• intestinal upset, diarrhea, constipation;
• headache;
• dizziness.

Such symptoms may indicate that the body is in dire need of increasing cholesterol levels. The deficiency of this element is a consequence of long-term use of drugs from the statin group. Everything useful is, in fact, useful in moderation.

The statin group of drugs has a positive effect when it comes to lowering cholesterol levels. And if a deficiency of an important element is established, the drugs can cause significant harm. They act excellently as preventative agents for maintaining the health of the heart system and blood vessels.

Proper nutrition

If a patient is diagnosed with chronically high cholesterol levels, then statin drugs are indicated for the rest of their life.

You can try to independently control the amount of this element in the body by following a certain diet, during which you need to pay more attention to the following products:

• low-fat cottage cheese;
• low fat milk;
• egg whites;
• fish meat;
• turkey, chicken;
• fruits vegetables;
• oil: soybean, sunflower, corn.

If you follow the dosage of statin drugs and at the same time adhere to this diet, then it is quite possible to normalize your cholesterol levels. Thanks to a sufficient amount of this element, a person feels a surge of strength, his well-being improves significantly. But in order to avoid negative effects that may interfere with drug therapy, it is worth completely eliminating the use of alcoholic beverages from the diet, even in small doses.

To reduce cholesterol, you need to exclude the following list of foods:

• pork liver;
• fat meat;
• egg yolks;
• natural milk;
• natural fat;
• any confectionery products;
• chips, crackers.

Simply following a healthy diet will help reduce cholesterol levels, thereby protecting you from cardiovascular problems. Obesity, first of all, affects the body's ability to cope with important functions, so it is necessary to do everything possible to bring your weight back to normal.

Functions of cholesterol

The most important property of this element is the restoration process of damaged tissues. It is the scar tissue that contains the most cholesterol. One of the important functional tissues is arterial. The artery is subject to destruction due to direct exposure to pathogenic acids, which are formed as a result of the accumulation of protein on the vascular walls.

The body's need for cholesterol is relieved by the work of the liver. It can increase its productivity by up to 45 percent. When an unexpected reaction occurs in the body, it leads to high cholesterol. There are many other reasons why you should not deliberately interfere with the process of developing this important element. If you start to reduce its level, you can lead to disruption of the entire mechanism. Drugs from the statin group perform precisely this function.

In the case when the body begins to exceed the production of an element, it is worth understanding the main reason. Perhaps, at the moment, this is exactly what is required for the proper functioning of the body. Artificial influence on the amount of this substance can deprive the natural protection from a large number of health problems, which can result in a sad clinical picture. The adrenal gland system, which is responsible for the production of hormones important for life, immediately begins to suffer. And this can lead to the appearance of pathological symptoms:

• high glucose levels;
• swelling;
• inflammatory lesions of soft tissues;
• lack of amino acids, microelements;
• allergic manifestations;
• asthma;
• decreased libido;
• infertility;
• reproductive dysfunction;
• pathological brain lesions.

The worst symptom is the last one. Long-term use of the statin group can lead to this.

Danger of combination with alcohol

Compatibility of treatment with the use of alcoholic beverages may be allowed in extremely rare cases. As a rule, this depends on the etiology of the disease and its clinical course.

It is always worth remembering the possible serious consequences of such a combination. Alcohol greatly increases the destructive effect on the structure of the liver and its activity. As a result, liver cells stop responding to incoming products and processing them. Soon the cells will begin to be replaced by connective tissue, which carries a great danger in the form of a terrible disease, namely cirrhosis. This combination can provoke a number of complex exacerbations, which will not be easy to cope with not only for patients, but also for medical staff.

Alcoholic drinks affect the effectiveness of medications. In addition, some medications may cause symptoms such as fatigue or drowsiness. Alcohol may increase these side effects. Before drinking alcohol and statins, you should talk to your doctor to find out exactly the reasons for stopping alcohol during medical therapy. Together with your doctor, you can decide what is most suitable for your specific body.

Before deciding to allow yourself a small dose of alcohol, you should think a hundred times about the possible risks. If you are undergoing treatment, then you should devote time to your health and recovery. And then you can cut yourself some slack. This especially applies to the period when most of the path to healing has already been completed, and all the results obtained may come to naught.

Kestin is capable of influencing H1 type histamine receptors via competitive inhibition.

Ebastine does not displace histamine from connections with receptors, but binds to free receptors.

This helps stop the development of an allergic reaction.

The drug is effective as a prophylactic against allergic reactions.

As a result of a decrease in the influence of histamine on receptors, a decrease in the intensity of bronchospasm, a decrease in pathological capillary permeability and tissue swelling are observed.

Kestin has an antiallergic, antihistamine effect and may have a sedative effect on the patient.

Indications and dosage:

Kestin is indicated for:

Seasonal allergic rhinitis

Renitis associated with household allergens, pollen, drugs

Food allergies

Allergies to epidermal particles

Hives caused by any type of allergen

Conditions caused by increased histamine production

For adults and children over 15 years of age, the drug is prescribed 10-20 mg (1/2-1 tablet) 1 time/day.

Children aged 12 to 15 years - 10 mg (1/2 tablet) 1 time / day.

In patients with impaired liver function, the daily dose should not exceed 10 mg.

The drug is taken regardless of meals.

In pediatrics and in cases of difficulty swallowing tablets, it is preferable to use Kestin syrup.

If you have an individual reaction to the drug with the appearance of drowsiness, you should stop driving and postpone engaging in hazardous activities.

Overdose:

Exceeding the dosage of ebastine may be accompanied by increased unwanted side effects.

There is no specific antidote.

Adsorbents are prescribed, gastric lavage is prescribed, and the patient is admitted to a medical facility to monitor the condition and carry out symptomatic therapy.

Side effects:

Taking Kestin may be accompanied by:

Drowsiness

Dry mouth

Headache

Nausea

Dyspepsia

Asthenic syndrome

Insomnia

Epigastric pain

Sinusitis

Contraindications:

Kestin is not prescribed for:

Lactation

Hypersensitivity to ebastine, tablet components

Pregnancy

Indications for children under 6 years of age

In case of renal failure, prolongation of the QT interval, disorders of hepatic metabolism, hypokalemia, Kestin should be prescribed with caution.

There are no reliable data on the safety of clinical use of Kestin and its analogues during pregnancy.

Preparations containing ebastine are not prescribed to pregnant women.

Interaction with other drugs and alcohol:

The drug Kestin is incompatible with antifungal agents containing ketoconazole, as well as with erythromycin antibiotics.

No significant pharmacological interactions have been recorded with other drugs.

Composition and properties:

1 tablet of Kestin contains:

Ebastine micronized 0.01 g

Auxiliary components: MCC, starch, lactose, sodium CMC, magnesium stearate, HPMC, PEG-6000, titanium dioxide

5 ml of Kestin syrup contains:

Ebastine 0.005 g

Auxiliary components: α-hydroxypropionic acid, glycerin, glycerol oxystearate, sodium propylparaben, sodium methylparaben, sorbitol, neohesperidin dihydrochalcone, dimethylpolysiloxane, anethole, sodium hydroxide, prepared water

Release form:

Kestin is produced in tablet form and syrup form. The packaging is as follows:

5 tablets/1 blister/packaging

10 tablets/1 blister/packaging

Syrup 60 ml/glass bottle with dispenser syringe included/packaging

Syrup 120 ml / glass bottle with dispenser syringe included / packaging

Storage conditions:

The storage temperature for Kestin syrup is 15-25 degrees Celsius, for tablets – up to 30 degrees Celsius.

The drug Kestin should be kept during storage in a dry place, protected from sunlight.

Children's access to both tablets and syrup should be limited.

The shelf life of syrup is 2 years, Kestin tablets are 3 years.

general information

Sales form:

Allergy is a disease that cannot be ignored. The body's negative reaction to certain stimuli can be truly unpredictable. Allergy sufferers should always have a high-quality antihistamine with them. The drug "Kestin" shows excellent results. Instructions for use make it possible to understand how to use the medication correctly.

Description and main components of the medicine

The drug "Kestin" will help you quickly cope with an allergic reaction. The instructions for use indicate that the active ingredient is ebastine. This substance blocks histamine receptors in a matter of minutes. Thanks to this, unpleasant allergy symptoms disappear.

The drug "Kestin" is available in two forms. These are syrup and tablets. Additionally, the medication may contain substances such as aspartame, mannitol, flavorings, and gelatin.

Ebastine stops the functioning of histamine receptors for a long time. Therefore, all drugs based on it are considered effective. Kestin is no exception. Instructions for use show that a strong antihistamine effect occurs within half an hour after consuming the tablets or syrup. The medicine continues to give good results for 72 hours.

Pharmacokinetics

Before using Kestin, you must read the instructions for use. Tablets for adults are suitable for almost all cases of allergies. After consumption, the drug is quickly absorbed from the gastrointestinal tract and is almost completely metabolized in the liver. In the blood plasma, the highest concentration of the active ingredient is observed after a few hours.

A specialist may prescribe a course of the drug "Kestin". Instructions for use, price, reviews, analogues - this information must be carefully read before starting treatment. When taken daily, after three days the highest concentration in the blood plasma reaches 150 ng/ml. Ebastine is 95% bound to blood proteins. Most of the tablets are excreted by the kidneys.

When to prescribe the drug

Kestin tablets can be prescribed to patients over 15 years of age with allergic rhinitis. The drug is also used for skin reactions - urticaria, minor rashes. For allergic laryngitis, the medication does not show good results. In pediatric practice, the medicine can be used in the form of syrup. At the same time, the drug is prescribed to preschool patients with caution.



It is strictly forbidden to use the medication in any form for phenylketonuria. Prescribe the drug with caution to patients with renal or liver failure. Contraindications also include the period of pregnancy and breastfeeding.

In rare cases, hypersensitivity to elements of the drug may develop. If the allergic reaction worsens, it is recommended to stop taking the medication. A specialist will be able to prescribe a high-quality substitute.

special instructions

It is worth considering that the active ingredient may affect allergy tests. Therefore, during the examination period, the use of the medicine should be discontinued. You should definitely tell your doctor if you have to take antihistamine tablets. Allergy tests are recommended to be carried out no earlier than a week after discontinuation of the medication.

During therapy with ebastine-based drugs, performance may decrease. The patient will feel slightly tired in the afternoon. It is not recommended to drive cars or other machinery that require increased attention during this period.

In almost any pharmacy you can find the drug "Kestin". The instructions for use indicate that the medicine can be dispensed without a prescription.

Features of application

Both syrup and tablets can be used regardless of diet. Adult patients, as well as patients over 15 years of age, are prescribed one capsule for resorption under the tongue. It is enough to take the drug once every 24 hours. The course of therapy depends on the symptoms. There is no need for dosage adjustment in patients over 65 years of age. For liver failure, it is recommended to take no more than 10 mg (half a tablet) per day.



The dosage of syrup is selected according to the age of the patient. For children under 6 years old, it is enough to take 5 ml once every 24 hours. Teenagers take 10 ml of the drug per day. Patients over 15 years of age can take up to 20 ml per day, provided there are no contraindications. No adverse reactions will occur if Kestin is used correctly. Instructions for use, price, reviews - this information should be carefully read. The daily dose of medication should not exceed 20 mg for tablets or 20 ml of liquid form.

Side effects

Improper use of any medication can lead to serious side effects. No troubles will arise if you have previously studied the instructions for use for the drug “Kestin”. Reviews from doctors show that unpleasant reactions of the body most often develop if the patient exceeds the dosage. In the most difficult cases, a rapid decrease in pressure is possible, and hypotension develops. The problem is that there is no special antidote for ebastine. In case of overdose, the patient must rinse the stomach. Then symptomatic therapy is carried out.



Side effects can also develop if the drug is taken correctly. At the beginning of therapy, many patients complain of increased fatigue, headache, and nausea. You may suffer from insomnia for several days. In rare cases, side effects from the respiratory system occur. Allergic rhinitis begins to intensify, shortness of breath appears.

Almost all patients at the beginning of treatment note increased dryness of the oral mucosa. The unpleasant phenomenon goes away within a few days.

Drug interactions

Can Kestin be used with all medications? The instructions for use of the tablets say that the simultaneous use of an antihistamine with antibiotics based on ketoconazole or erythromycin is not recommended. This interaction may reduce the effectiveness of the antiallergy drug.



Unpleasant side effects may develop while taking ethanol-based solutions. It is strictly forbidden to drink alcohol during the treatment period.

What product should I use if I couldn’t find the drug “Kestin” at the pharmacy? Instructions for use, analogues - your doctor will be able to tell you about all this. A specialist will always select a high-quality substitute. The most popular means will be described below.

"Espa-Bastin"

The medication is available in tablet form. It can be used if you were unable to purchase the drug Kestin. Ebastine also plays the role of the active component here. 90% of the medicine is absorbed from the gastrointestinal tract. The positive effect occurs within half an hour after taking the medicine orally. The advantage is that the tablets do not have a pronounced sedative effect. However, it is still recommended to refrain from driving a car during the treatment period.



As in the case of Kestin, the instructions for use should be carefully studied. The price of analogues is practically the same. For a box of medicine you will have to pay about 250 rubles.

The drug "Espa-Bastin" is prescribed with caution to patients with impaired liver and kidney function. People with such pathologies require dose adjustment. The medicine is not used during pregnancy and lactation. Children are also not prescribed medication in tablet form.

"Histafen"

What else can replace the drug "Kestin"? Instructions for use, price, reviews, analogues - all this information should be carefully studied by those who want to forget about allergies forever. A good histamine receptor blocker is the substance sehifenadine. It was on its basis that the Gistafeng tablets were created. This drug copes well with many allergic reactions. The advantage is that the active component not only blocks histamine receptors, but also reduces the content of harmful substances in the body tissues. Sehifenadine is rapidly absorbed from the gastrointestinal tract. The maximum effect is achieved within 40 minutes after taking the drug orally.

The drug "Histafen" has a long list of indications. It can be used not only for allergic rhinitis or urticaria. The product also shows good results for itchy dermatoses and conjunctivitis. The medication can be used to prevent seasonal allergic manifestations.

"Suprastin"

Those who want to save money should pay attention to this drug. For one package of the product you will have to pay no more than 150 rubles. Before starting therapy, the instructions for use should be studied qualitatively, as in the case of the drug “Kestin”. Although analogues are available without a prescription, they can cause harm to the body if used incorrectly.



The active ingredient is: Additionally, the tablets contain substances such as lactose monohydrate, stearic acid, potato starch, and talc.

The drug "Suprastin" shows good results for seasonal or allergic rhinitis, urticaria, eczema, contact dermatitis, etc. The medication can be prescribed to children over 3 years of age.

To effectively combat allergies and their manifestations, many medications have been developed, the therapeutic effect of which is to block histamine type H1 receptors. The second-generation antiallergic drug "Kestin" (international nonproprietary name - ebastine) belongs to the middle price category.

Since the active ingredient ebastine is contained only in Kestin, there are no analogues of this drug similar in structure to it. In different countries, ebastine is produced under various names, including Aleva, Ebastine, Ebatrol, Evastin, Kestine and others. The drug has good reviews.

"Kestin": instructions for use

Pharmacological action and pharmacokinetics

"Kestin" carries out a competitive blockade H1 receptors of the neurotransmitter histamine, resulting in reduced vascular permeability and the risk of spasm of bronchial smooth muscles. The drug has a long-lasting effect, which manifests itself an hour after administration and lasts two days.

Absorption occurs immediately after ingestion. In the liver, the active substance is converted into the metabolite carebastine. The absorption and formation of carebastine can be accelerated by eating fatty foods.

During treatment with Kestin, a gradual accumulation of carebastine occurs in the body, so at the end of the course therapeutic effect is maintained for another six days. With continuous use of the drug for three days, the equilibrium concentration of the metabolite is established in the range of 130–160 ng/ml. The drug has no sedative effect.

The drug is excreted from the body by the kidneys. Half of the pharmacological effect is lost after 15–19 hours; in case of liver and kidney failure, this figure can reach 27 and 23–26 hours, respectively.

Release form

"Kestin" is presented in the following forms:

• White tablets or almost white in a film shell. The concentration of the active substance in the tablet is 10 or 20 mg. Ingredients: ebastine, cellulose, starch, magnesium stearate, lactose monohydrate, croscarmellose sodium, titanium dioxide. The tablets are engraved “E10” or “E20” on one side.
• Lyophilized tablets(instant) for resorption. Ingredients: ebastine (10 mg), gelatin, mannitol, aspartame sweetener, mint flavor.
• Clear syrup with anise flavor. Supplied in a dark glass bottle with an aluminum cap and a measuring syringe included. Syrup composition: ebastine, glycerin, sorbitol solution, glycerol oxystearate, lactic acid, sodium methyl parahydroxybenzoate, water, other substances in a concentration of less than 1 mg, acidity regulator.

Indications for use

"Kestin" is prescribed for the following conditions:

• allergic rhinitis of various origins,
• allergic conjunctivitis,
• urticaria of various origins,
• Quincke's edema,
• other diseases caused by high concentrations of histamine.

Contraindications

You should avoid taking Kestin if you are highly sensitive to its components, as well as during pregnancy. Tests of the drug on animals have confirmed the harmlessness of ebastine to the fetus, but there is currently no data on this kind of effect on the human body. It is also unknown whether ebastine and its metabolite carebastine are excreted in breast milk, so the drug should not be used by nursing mothers.

The medicine is contraindicated in people with lactase deficiency, lactose intolerance and glucose-galactose malabsorption.

Some forms of "Kestin" ( oral tablets) is not prescribed for protein metabolism disorders. Lyophilized tablets are contraindicated for children and adolescents under 15 years of age, coated tablets are contraindicated for children under 12 years of age. The use of the drug is not recommended for children under six years of age.

Patients with hypokalemia, hepatic or renal failure and an increased QT interval should take Kestin with caution.

Side effects

At therapeutic doses, the drug causes few side effects. Sometimes its use leads to drowsiness, headache and dry mouth. Isolated cases of sinusitis and rhinitis have been reported, as well as nausea, abdominal pain and sleep disturbance.

The drug does not have a negative effect on the central nervous system, so patients are allowed to engage in activities that require high concentration: for example, driving a car.

An overdose, in which the patient feels fatigue and dry mouth, can only be caused by simultaneous intake of at least a thirty-fold dose of Kestin. Since there is no drug that could weaken or neutralize the effect of ebastine, in case of overdose it is necessary to cleanse the stomach and treat individual symptoms.

Mode of application

Kestin is taken orally once a day. Meal times don't matter. The medicine does not need to be taken with water. The dosage differs for children and adults:



The maximum daily dose of the drug for the treatment of patients with liver dysfunction is 10 mg.

Lyophilized tablets are designed to be dissolved in the mouth. They do not have a shell and are generally quite fragile, so they should be removed from the blister carefully, without pressing.

Interaction with other drugs

• fluconazole, ketoconazole and other antifungal agents,
• erythromycin, roxithromycin and other macrolides (increase the risk of prolongation of the QT interval).

No interactions have been identified with the following drugs:

• indirect anticoagulants,
• theophylline,
• cimetidine,
• tranquilizer diazepam,
• alcohol and alcohol-containing drugs.

Where can I buy Kestin?

Antihistamines are usually sold in pharmacies without a prescription; “Kestin” is no exception. Prices for the drug depend on the form of release: tablets containing 10 mg ebastine, produced in quantities of 5 pieces. in a package, they cost a little more than 250 rubles - this is enough for one course of treatment. However, for frequent use and in severe cases of the disease, it is more profitable to choose packages of 10 tablets containing 10 and 20 mg of the active substance.

How to replace the drug "Kestin"?

On a trip abroad

If a drug with the familiar name Kestine is not available in a foreign pharmacy, you should look for other medications that have the international nonproprietary name ebastine. The instructions for use of these medications are the same as for Kestin, since they are essentially synonymous drugs. List of some ebastine-based medications:

• Egypt: Bastab, Evastine.
• Spain: Alastina, Ebastina Combix.
• Italy: Clever.
• India: Ebast, Erostin.
• Netherlands: Lacinet, Netan, Notaxo, Stibal.
• Philippines: Co-Aleva, Histagone.
• Finland: Kestine Lyo.
• China: Si Jin, Su Di.
• Japan: Ebastine Choseido.

In case of intolerance to components

Any H1 receptor blocker of the histamine neurotransmitter is suitable to replace Kestin. When selecting an analogue, you need to pay attention to the generation. It is recommended to use second-generation analogues (loratadine, cetirizine) or their active metabolites of the third and fourth generations. They relieve allergies more effectively and have fewer side effects. These drugs include desloratadine and levocetirizine.



If taking Kestin is impossible for any reason, be it being in another country, individual intolerance to the auxiliary components or active substance, childhood or old age, pregnancy, you can find a worthy replacement. In this case, it is best to entrust the selection of a similar drug to a specialist.