Instructions for use of the drug Lincomycin: characteristics of proper treatment. What does Lincomycin help with? Lincomycin instructions for use injections for children

In this article you can read the instructions for use of the drug Lincomycin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Lincomycin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Lincomycin in the presence of existing structural analogues. Use for the treatment of abscess, endocarditis and other infectious and inflammatory diseases in adults, children, as well as during pregnancy and lactation.

Lincomycin- antibiotic of the lincosamide group. In therapeutic doses it acts bacteriostatically. At higher concentrations it has a bactericidal effect. Suppresses protein synthesis in microbial cells.

Active primarily against aerobic gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae /except Enterococcus faecalis/), Corynebacterium diphtheriae; anaerobic bacteria Clostridium spp., Bacteroides spp.

Lincomycin is also active against Mycoplasma spp.

Most gram-negative bacteria, fungi, viruses, and protozoa are resistant to lincomycin. Resilience is developed slowly.

Cross-resistance exists between lincomycin and clindamycin.

Compound

Lincomycin (in the form of hydrochloride monohydrate) + excipients.

Pharmacokinetics

After oral administration, 30-40% is absorbed from the gastrointestinal tract. Eating slows down the rate and extent of absorption. Lincomycin is widely distributed in tissues (including bone) and body fluids. Penetrates through the placental barrier. Partially metabolized in the liver. It is excreted unchanged and in the form of metabolites in urine, bile and feces.

Indications

severe infectious and inflammatory diseases caused by microorganisms sensitive to lincomycin, incl. sepsis, osteomyelitis, septic endocarditis, pneumonia, lung abscess, pleural empyema, wound infection;
as a reserve antibiotic for infections caused by strains of staphylococcus and other gram-positive microorganisms resistant to penicillin and other antibiotics;
for local use: purulent-inflammatory skin diseases.

Release forms

250 mg capsules (sometimes mistakenly called tablets).

Solution for intravenous and intramuscular administration (injections in injection ampoules) 300 mg/ml.

Ointment for external use.

Instructions for use and dosage

When taken orally by adults - 500 mg 3-4 times a day or intramuscularly - 600 mg 1-2 times a day. 600 mg is administered intravenously in 250 ml of isotonic sodium chloride or glucose solution 2-3 times a day.

Children aged 1 month to 14 years orally - 30-60 mg/kg per day; administered intravenously at a dose of 10-20 mg/kg every 8-12 hours.

When applied topically, apply a thin layer to the affected areas of the skin.

Side effect

nausea, vomiting;
epigastric pain;
diarrhea;
glossitis;
stomatitis;
with long-term use in high doses, the development of pseudomembranous colitis is possible;
reversible leukopenia, neutropenia, thrombocytopenia;
hives;
exfoliative dermatitis;
Quincke's edema;
anaphylactic shock;
candidiasis;
phlebitis (with intravenous administration);
decreased blood pressure, dizziness, general weakness (with rapid intravenous administration).

Contraindications

severe dysfunction of the liver and/or kidneys;
pregnancy;
lactation;
hypersensitivity to lincomycin and clindamycin.

Use during pregnancy and breastfeeding

Lincomycin crosses the placental barrier and is excreted in breast milk. Use during pregnancy is contraindicated. If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.

special instructions

If liver and/or kidney function is impaired, the single dose of lincomycin should be reduced by 1/3 - 1/2 and the interval between doses should be increased. With long-term use, systematic monitoring of kidney and liver functions is necessary.

If pseudomembranous colitis develops, lincomycin should be discontinued and vancomycin or bacitracin should be prescribed.

Drug interactions

When used simultaneously with penicillins, cephalosporins, chloramphenicol or erythromycin, antagonism of the antimicrobial effect is possible.

When used simultaneously with aminoglycosides, synergistic action is possible.

When used simultaneously with inhalation anesthesia or peripherally acting muscle relaxants, an increase in neuromuscular blockade is observed, up to the development of apnea.

Taking antidiarrheal drugs reduces the effect of lincomycin.

Pharmaceutical interactions

Pharmaceutically incompatible with ampicillin, barbiturates, theophylline, calcium gluconate, heparin and magnesium sulfate.

Lincomycin is incompatible in the same syringe or dropper with kanamycin or novobiocin.

Analogues of the drug Lincomycin

Structural analogues of the active substance:

Lincomycin-AKOS;
Lincomycin hydrochloride;
Lincomycin hydrochloride capsules 0.25 g;
Lincomycin hydrochloride solution for injection 30%;
Neloren;
Films with lincomycin.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Lincomycin is an antibiotic from the lincosamide group.

Composition and release form of Lincomycin

Lincomycin is available in various dosage forms:

Lincomycin capsules;
Lyophilisate for preparing a solution for intramuscular and intravenous administration;
Solution for intramuscular and intravenous administration;
Lincomycin ointment for external use.

The main active ingredient of the drug is lincomycin hydrochloride.

Pharmacological action of Lincomycin

According to the instructions, Lincomycin is an antibiotic produced by Streptomyces lincolniensis, which has a pronounced bacteriostatic effect. The use of Lincomycin inhibits the synthesis of bacterial proteins and disrupts the formation of peptide bonds.

Lincomycin hydrochloride is active against some gram-positive cocci, Mycoplasma spp., Bacillus anthracis, Haemophilus influenzae, Corynebacterium diphtheriae, Bacteroides spp., Clostridium tetani, Clostridium perfringens. Effective against Staphylococcus spp., resistant to tetracyclines, penicillin, streptomycin, chloramphenicol and cephalosporins.

It works most effectively in an alkaline environment (pH 8-8.5).

Indications for use of Lincomycin

According to the instructions, Lincomycin is prescribed for the treatment of bacterial infections caused by microorganisms sensitive to lincomycin hydrochloride (streptococci and staphylococci), as well as microorganisms resistant to penicillins, or in case of allergies to the penicillin group:

Subacute septic endocarditis;
Sepsis;
Chronic pneumonia;
Osteomyelitis (in chronic or acute form);
Otitis;
Pleurisy;
Empyema of the pleura;
Lung abscess;
Purulent arthritis;
Purulent complications in the postoperative period;
Infections of soft tissues and skin;
Wound infections.

In dentistry, Lincomycin is prescribed for the treatment of various infections of the maxillofacial system. As a rule, dentists prefer this drug for its ability to be deposited in teeth and bone tissue.

The use of Lincomycin in dentistry in combination with lidocaine for the treatment of purulent processes in periodontitis, gingivitis, and periodontitis is widespread. Since there are no direct indications for the use of Lincomycin in dentistry, the issue of prescribing the drug must be resolved only with the attending physician.

Directions for use and dosage

The daily dose of Lincomycin for parenteral administration is 1.8 g, single - no more than 0.6 g. If the infection is severe, the dosage can be increased to 2.4 g, divided into three doses with an eight-hour interval. For children, the dose of lyophilisate when administered intravenously is 10-20 mg/kg, regardless of age. Lincomycin is administered intravenously only by drip, the optimal rate is 60-80 drops/min.

Lincomycin capsules are taken orally 1-2 hours before meals. For adults, the maximum dosage of Lincomycin capsules is 1-1.5 g, and a single dosage is no more than 0.5 g. For children, Lincomycin capsules should not be prescribed more than 30-60 mg/kg per day.

The duration of treatment with Lincomycin depends on the form of the disease, but generally does not exceed 1-2 weeks. The exception is osteomyelitis, when treatment can last up to three or more weeks.

If the course of treatment is long, it is necessary to monitor liver and kidney functions.

Contraindications

Lincomycin in any dosage form is contraindicated:

In case of hypersensitivity to lincomycin hydrochloride;
During pregnancy and breastfeeding (it has been proven that lincomycin hydrochloride passes through the placenta and into breast milk);
In case of severe renal and liver failure;
In childhood up to 1 month.

According to the instructions, Lincomycin is prescribed with caution for fungal diseases of the skin, vagina, oral mucosa, myasthenia gravis (when administered parenterally).

Side effects of Lincomycin

The use of Lincomycin may cause the following adverse reactions:

Hematopoietic system: reversible thrombocytopenia, leukopenia, neutropenia;
Digestive system: diarrhea, nausea, vomiting, pain in the epigastric region, glossitis, gastrointestinal candidiasis, increased activity of liver enzymes, transient hyperbilirubinemia, pseudomembranous enterocolitis;
Allergies: exfoliative dermatitis, urticaria, anaphylactic shock, angioedema.

With intravenous administration, phlebitis may develop. If administered intravenously too quickly, a decrease in blood pressure, asthenia, dizziness, and weakness of skeletal muscles may occur.

special instructions

To prevent the development of aseptic necrosis and thrombophlebitis, it is better to administer Lincomycin deeply intramuscularly. It is prohibited to administer the drug intravenously without prior dilution.

Caution should be exercised when prescribing the parenteral form of the drug to premature infants, as this can lead to the development of bronchospasm.

Drug interactions

Lincomycin hydrochloride is pharmaceutically incompatible with ampicillin, theophylline, kanamycin, calcium gluconate, magnesium sulfate, barbiturates, and heparin.

When administered parenterally, Lincomycin enhances the neuromuscular blockade caused by muscle relaxants.

The human body contains a huge number of bacteria. Some of them are beneficial, but there are some that can provoke undesirable consequences of such a neighborhood. The fight against infection includes antibiotics that stop the proliferation of bacteria and the development of possible complications.

Lincomycin - brief description, composition, release forms

Lincomycin is an antibiotic from the lincosamide group, which can effectively stop the inflammatory process and prevent the spread of bacteria. A high result is achieved by the fact that the active substance has the ability to accumulate in tooth tissues. The main component of the drug is lincomycin hydrochloride.

In addition to this, the drug contains:

calcium stearate;
Aerosil;
microcrystalline cellulose.

The composition of the product may vary depending on the manufacturer.

This antibacterial drug is available in the form:

capsules;
solutions for injections;
2% ointment;
special patch called diplen.

Capsules are produced in blisters in quantities 10 pieces. Each capsule contains 250 or 500 mg active substance. Cardboard packaging may include either 2 or 3 blisters.

Lincomycin solution for injection goes on sale in ampoules, according to 10 pieces packaged.

Diplene is a film consisting of two layers:

lower, in direct contact with the mucous membrane and impregnated with the drug;
upper, having moisture-repellent properties; thanks to it, the patch does not get wet, and the strip can remain in the oral cavity for a long time.

Pharmacological properties

Lincomycin has a bacteriostatic effect, disrupting protein synthesis in bacterial cells. The drug can be taken both internally and externally.

The drug has the following pharmacological properties:

fast absorption;
instantly stops the growth of bacteria, and when the dosage increases, it begins to destroy them;
when used internally, the maximum concentration of the drug in the blood is achieved within a few hours;
is able to penetrate the placenta and breast milk;
Most of the drug is eliminated from the body in the urine;
the maximum effect is manifested in an alkaline environment.

Indications for use in dentistry

The use of Lincomycin is possible in some cases:

inflammation of the jaw tissue with the addition of infection;
complications of periodontitis, periodontitis, such as suppuration, abscesses, fistulas;
prevention of infection development after tooth extraction or implant installation;
prevention of inflammation after removing tartar;
complications of ulcerative gingivitis;
with primary signs of osteomelitis;
removal of the inflammatory process due to removal of the denture;
for severe toothache.

During the treatment of purulent processes, injections of Lincomycin are supplemented with Lidocaine. For preventive purposes, you can rinse your mouth with a solution containing a drug.

Contraindications

Like any medicine, Lincomycin has limitations in its use. The product is contraindicated:

pregnant and lactating women;
children under 5 years of age;
with renal and liver failure;
if allergic reactions to lincomycin or clindomycin occur.

Use with extreme caution when:

fungus on the skin, mouth or genitals;
myasthenia gravis when administered intravenously or intramuscularly.

Directions for use and doses

The drug, released in the form of capsules, has the following application features:

dosage is 500 mg 3-4 times a day;
the duration of treatment reaches 1-2 weeks; for complicated diseases – up to 3;
the drug is taken a few hours before meals, capsules can be washed down with water;
Do not take the drug on an empty stomach or immediately after meals– the effectiveness of the drug will begin to decrease;
You should not drink alcohol during treatment; this leads to an acceleration of the removal of the active substance from the body and a decrease in its concentration in the blood.

When prescribing a drug in childhood, the daily dose is calculated based on the child’s weight - 30 mg per kilogram of body weight. According to indications, the dosage may be increased.

Lincomycin in the form of an ointment is applied to the affected area of the mucosa in a small layer several times a day. You should be careful if you have fungal skin diseases.

Injections of the solution are made every 8-12 hours. The dosage is determined by the person’s body weight - 10-20 mg per kilogram. Droppers are also placed in the same way, adjusting the speed of the order 60-80 drops per minute.

Diplene is glued to the affected area for 6-8 hours. After this period, the patch is carefully removed.

Side effects

In addition to its positive effects, this antibiotic can also cause undesirable consequences:

the appearance of stomatitis, inflammation of the tongue;
the possibility of developing neutropenia, thrombocytopenia or leukopenia;
disruptions in the functioning of the digestive system: nausea, vomiting, pain and colic, stool disturbances;
the appearance of a rash, urticaria;
itchy skin;
bleeding gums;
dysfunction of the liver and kidneys;
vaginitis;
allergic Quincke's edema;
anaphylactic shock.

Intravenous use of lincomycin also has a number of side effects if the drug is not administered correctly:

muscle weakness;
dizziness;
attacks of hypotension;
possible development of phlebitis.

Interaction with other drugs

Lincomycin should be used with caution in combination with certain drugs:

anti-inflammatory drugs can lead to breathing problems until it stops;
drugs to treat diarrhea are more likely to lead to pseudomembranous colitis;
erythromycin and chloramphenicol reduce the effect of lincomycin;
adsorbents slow down the elimination of the drug from the digestive organs;
anesthetics in the inhaler and muscle relaxants.

The drug can also reduce the effectiveness of ambenonium, pyridostigmine and neostigmine.

Prices and analogues

Analogues of Lincomycin can be used when bacteria become accustomed to the medication. The spectrum of action of such antibiotic agents is similar, but the composition is slightly different. These are:

tetracycline;
ofloxacin;
augmentin;
chloramphenicol;
vilprafen;
nystatin;
asicin.

These medicines may differ in the form of release. Before purchasing, be sure to read the instructions for use.

Cost of Lincomycin depends on the form in which the antibiotic is produced. So, the most expensive is considered to be the diplene patch. Solutions in ampoules are cheap.

Drug manufacturers also put their mark on the price of Lincomycin. So, the cost of antibiotic capsules varies from 20 to 130 rubles for 20 pieces. Ampoules can be purchased at 30-40 rubles per package.

The use of Lincomycin can quickly and effectively cope with bacteria and avoid worsening the situation. The effectiveness of this antibiotic has been proven over the years.

Instructions for use:

Lincomycin is an antibiotic used to treat various diseases caused by most gram-positive bacteria.

pharmachologic effect

Lincomycin, being an antibiotic, in therapeutic doses is active against:

Streptococcus spp., including Streptococcus pneumoniae;
Bacteroides spp.;
Mycoplasma spp.;
Staphylococcus spp., including strains that produce penicillinase;
Corynebacterium diphtheriae;
Clostridium spp.

According to the instructions, Lincomycin does not affect most gram-negative bacteria, viruses, Enterococcus faecalis, fungi and protozoa.

Lincomycin slowly develops resistance, is rapidly distributed in body tissues and fluids, including bone tissue, and penetrates the placental barrier.

When using Lincomycin, it should be taken into account that there is cross-resistance between clindamycin and the drug.

Release form

Lincomycin is available as:

White Lincomycin capsules with a yellow cap, containing 250 mg of the active substance - lincomycin hydrochloride, in the form of white powder, 10, 20, 360 pieces per package;
2% ointment for external use, 10 or 15 g in tubes;
A solution for intramuscular and intravenous administration of Lincomycin hydrochloride, containing 300 or 600 mg of active substance per ampoule, 5, 10, 100 ampoules per package.

Indications for use of Lincomycin

Lincomycin is used according to the instructions for the treatment of severe infectious and inflammatory diseases, including:

Septic endocarditis;
Pneumonia;
Sepsis;
Lung abscess;
Wound infections;
Osteomyelitis;
Pleural empyema.

Lincomycin ointment is used topically in the treatment of purulent-inflammatory skin diseases.

In dentistry, Lincomycin is used to treat various infections of the maxillofacial system. Its main advantage over other antibiotics is its ability to be deposited in bone tissue and teeth.

Quite often, Lincomycin in dentistry is used together with lidocaine to eliminate purulent processes in gingivitis, periodontitis or periodontitis.

Lincomycin is also used to avoid secondary infection on the wound surface in the socket area after tooth extraction. There is no clear opinion regarding the advisability of using the drug in these cases.

Also, there are no direct instructions in the instructions for the use of Lincomycin in dentistry, so the question of its use must be discussed with a doctor.

Contraindications to the use of Lincomycin

According to the description, Lincomycin is contraindicated in cases of sensitivity to the active ingredients of the drug (clindamycin or lincomycin), as well as in cases of severe impairment of kidney and liver function.

The use of Lincomycin is contraindicated during lactation and pregnancy due to the penetration of the drug through the placental barrier.

Instructions for use of Lincomycin

When taking Lincomycin in capsules, use 500 mg 3-4 times a day. Typically, the duration of treatment is from one to two weeks, with osteomyelitis - up to three weeks or more. Lincomycin capsules are taken several hours before meals with a small amount of liquid.

Lincomycin is used intravenously according to the instructions up to 2 times a day, 600 mg.

Lincomycin hydrochloride is administered intravenously by drip, 600 mg several times a day.

Children are prescribed Lincomycin capsules in a daily dose calculated as 30-60 mg per 1 kg of body weight.

If necessary, Lincomycin hydrochloride is administered intravenously every 8-12 hours at the rate of 10-20 mg per 1 kg of body weight.

When applied topically as an ointment, Lincomycin is applied in a thin layer to the affected areas of the skin several times a day. The ointment is used with caution for dermatomycosis and fungal skin diseases.

When using Lincomycin simultaneously with cephalosporins, penicillins, erythromycin or chloramphenicol, antagonism of the antimicrobial action may occur, and when used simultaneously with aminoglycosides, synergism of action may occur.

Lincomycin should be used with caution simultaneously with peripherally acting muscle relaxants and for inhalation anesthesia due to the possibility of increased neuromuscular blockade, sometimes leading to the development of apnea.

Antidiarrheal drugs lead to a decrease in the bactericidal effect of Lincomycin.

When using Lincomycin, it should be taken into account that the drug is pharmaceutically incompatible with:

Novobiocin;
Kanamycin;
Barbiturates;
Calcium gluconate;
Heparin;
Ampicillin;
Theophylline;
Magnesium sulfate.

Side effects of Lincomycin

According to instructions and reviews, Lincomycin may cause the following side effects:

Glossitis;
Epigastric pain;
Reversible leukopenia;
Stomatitis;
Exfoliative dermatitis;
Diarrhea;
Anaphylactic shock;
Increased levels of liver transaminases and bilirubin in blood plasma;
Nausea;
Candidiasis;
Neutropenia;
Vomiting;
Thrombocytopenia;
Urticaria;
Quincke's edema.

With long-term use of Lincomycin in high doses, the development of pseudomembranous colitis is possible.

With intravenous use, phlebitis may develop; with rapid intravenous administration, general weakness, dizziness, relaxation of skeletal muscles and a decrease in blood pressure may be observed.

Storage conditions

Lincomycin is available with a doctor's prescription. According to the description, the shelf life of Lincomycin capsules is 4 years, the solution for injection and ointment is 3 years.

Lincomycin is an antibiotic from the lincosamide group. Unlike, say, ampicillin synthesized in the laboratory, lincomycin is a natural product of the vital activity of microorganisms: it is produced by the actinomycetes Streptomyces lincolnensis and some of their “relatives”. The mechanism of action of lincomycin is similar to that of gentamicin: the antibiotic binds to the 50S (gentamicin - to the 30S) subunit of ribosomes and most directly interferes with the formation of peptide bonds, as a result of which the reading of genetic information is disrupted and defective proteins are synthesized at the output. True, unlike the same gentamicin, lincomycin forms reversible bonds with the receptors of the specified ribosomal unit, which are subsequently broken, hence the nature of the pharmacological effect: not bactericidal (destroying), but bacteriostatic, inhibiting the growth and development of microorganisms. However, lincomycin in high doses can also have a bactericidal effect. This statement is also true for average dosages of the drug in relation to bacteria highly sensitive to lincomycin.

Lincomycin is successfully used in the fight against infections caused by gram-positive (Staphylococcus spp., Streptococcus spp., Corynebacterium diphtheriae, Clostridium spp.) and gram-negative (Bacteroides spp., Mycoplasma spp.) microorganisms.

The special value of lincomycin is that it is effective against bacteria that exhibit resistance to a number of other antibiotics, for example, the same notorious Staphylococcus spp. Resistance to lincomycin develops slowly, but cross-resistance may also occur (for example, between lincomycin and clindamycin).

Lincomycin's disadvantages are helplessness against gram-negative bacteria, Enterococcus spp., viruses, fungi, protozoa, relative uselessness in the fight against Neisseria spp., Corynebacterium spp., spore-forming anaerobes (in any case, lincomycin is clearly inferior to erythromycin here).

Lincomycin is available in capsules, solution for intravenous and intramuscular injections and ointment for external use (“Lincomycin-akos”). Capsules are taken 1-2 hours before meals. Recommended doses: 1-1.5 g daily and 0.5 g single (for adults) and 30-60 mg per 1 kg daily (for children). The duration of the antibacterial course is on average 1-2 weeks. For the injection form of lincomycin, the daily dose is 1.8 g (adults) and 10-20 mg per 1 kg (children). Long-term therapeutic courses require careful monitoring of the activity of the liver and kidneys. Lincomycin ointment is used externally: it is applied in a thin layer to the infected area of the skin 2-3 times a day.

Pharmacology

Antibiotic of the lincosamide group. In therapeutic doses it acts bacteriostatically. At higher concentrations it has a bactericidal effect. Suppresses protein synthesis in microbial cells.

Lincomycin is also active against Mycoplasma spp.

Most gram-negative bacteria, fungi, viruses, and protozoa are resistant to lincomycin. Resilience is developed slowly.

Cross-resistance exists between lincomycin and clindamycin.

Pharmacokinetics

After oral administration, 30-40% is absorbed from the gastrointestinal tract. Eating slows down the rate and extent of absorption. Lincomycin is widely distributed in tissues (including bone) and body fluids. Penetrates through the placental barrier. Partially metabolized in the liver. T1/2 is about 5 hours. It is excreted unchanged and in the form of metabolites in urine, bile and feces.

Release form

1 ml - ampoules (10) - cardboard packs.

Dosage

When applied topically, apply a thin layer to the affected areas of the skin.

Interaction

When used simultaneously with penicillins, cephalosporins, chloramphenicol or erythromycin, antagonism of the antimicrobial effect is possible.

When used simultaneously with aminoglycosides, synergistic action is possible.

When used simultaneously with inhalation anesthesia or peripherally acting muscle relaxants, an increase in neuromuscular blockade is observed, up to the development of apnea.

Taking antidiarrheal drugs reduces the effect of lincomycin.

Pharmaceutical interactions

Pharmaceutically incompatible with ampicillin, barbiturates, theophylline, calcium gluconate, heparin and magnesium sulfate.

Lincomycin is incompatible in the same syringe or dropper with kanamycin or novobiocin.

Side effects

From the digestive system: nausea, vomiting, epigastric pain, diarrhea, glossitis, stomatitis; transient increase in the level of liver transaminases and bilirubin in the blood plasma; with long-term use in high doses, the development of pseudomembranous colitis is possible.

From the hematopoietic system: reversible leukopenia, neutropenia, thrombocytopenia.

Allergic reactions: urticaria, exfoliative dermatitis, Quincke's edema, anaphylactic shock.

Effects due to chemotherapy: candidiasis.

Local reactions: phlebitis (with intravenous administration).

With rapid intravenous administration: decreased blood pressure, dizziness, general weakness, relaxation of skeletal muscles.

Indications

Severe infectious and inflammatory diseases caused by microorganisms sensitive to lincomycin, incl. sepsis, osteomyelitis, septic endocarditis, pneumonia, lung abscess, pleural empyema, wound infection. As a reserve antibiotic for infections caused by strains of staphylococcus and other gram-positive microorganisms resistant to penicillin and other antibiotics.

For local use: purulent-inflammatory skin diseases.

Contraindications

Severe liver and/or kidney dysfunction, pregnancy, lactation, hypersensitivity to lincomycin and clindamycin.

Features of application

Use during pregnancy and breastfeeding

Use for liver dysfunction

Contraindicated in cases of severe liver dysfunction.

If liver function is impaired, the single dose of lincomycin should be reduced by 1/3 - 1/2 and the interval between doses should be increased. With long-term use, systematic monitoring of liver function is necessary.

Use for renal impairment

Contraindicated in cases of severe renal impairment.

If renal function is impaired, the single dose of lincomycin should be reduced by 1/3 - 1/2 and the interval between doses should be increased. With long-term use, systematic monitoring of renal function is necessary.

Use in children

Children aged 1 month to 14 years orally - 30-60 mg/kg/day; administered intravenously at a dose of 10-20 mg/kg every 8-12 hours.

special instructions

If liver and/or kidney function is impaired, the single dose of lincomycin should be reduced by 1/3-1/2 and the interval between doses should be increased. With long-term use, systematic monitoring of kidney and liver functions is necessary.

If pseudomembranous colitis develops, lincomycin should be discontinued and vancomycin or bacitracin should be prescribed.