Gastal instructions for use. What Gastal helps with: indications for use. Correct use of Gastal: before or after meals

1. Pharmacological action

2. indications for use

• Heartburn and other discomfort in the stomach caused by various reasons;
• Reverse movement of food into the esophagus;
• Diseases of the digestive system, accompanied by increased secretion of hydrochloric acid;
• Diaphragmatic.

3. Method of application

Half or a whole tablet an hour after meals, no more than 6 times a day.

The maximum number of Gastal tablets taken should not exceed 4 pieces.

One or two tablets an hour after meals, no more than 6 times a day.

The maximum number of Gastal tablets taken should not exceed 8 pieces.

The duration of treatment is no more than two weeks.

One or two tablets up to 6 times a day, regardless of meals.

In all cases, Gastal is taken as follows: the tablet must be kept on until it is completely absorbed.

Features of application:

• For patients suffering from chronic renal failure, no dose adjustment is required;
• Gastal does not affect the reaction rate and does not cause drowsiness, as a result of which it is approved for use by persons whose activities involve operating complex mechanisms, including vehicles of all types.

4. Side effects

All side effects occur in isolated cases and are associated with the use of the drug in extremely high dosages or with the use of the drug in patients with hypersensitivity.

5. Contraindications

6. During pregnancy and lactation

Gastal is not excreted in breast milk, and therefore it is approved for use during breastfeeding.

7. Interaction with other drugs

• Levodopa or Nadlidixic acid, there is an increase in the activity of the latter;
• , drugs containing iron ions, Aminazine, Diflunisal, drugs containing fat-soluble vitamins, drugs of the barbiturate group, quinolones, Ciprofloxacin, Indomethacin, drugs that block the receptors of adrenaline or histamine, Ofloxacin and drugs that reduce the ability of blood to clot , leads to a decrease and slowdown in absorption of the latter, which may require adjustment of their dosage;
• Captopril, the bioavailability of the latter is significantly reduced;
• Metoprolol leads to a decrease in the plasma concentration of the latter;
• with drugs that slow down gastric motility, an increase in the duration of action of Gastal is observed;
• antibiotics of the tetracycline group leads to the formation of insoluble complex compounds.

8. Overdose

• Ion balance disorders (decrease in the level of calcium ions in the blood, decrease in the level of phosphorus ions in the blood, increase in the level of calcium ions in the urine, increase in the level of magnesium ions in the blood, increase in aluminum ions in the blood);
• Metabolic disorders (destruction of bone tissue, increased fragility of bone tissue);
• Disorders of the urinary system (functional disorders of the kidneys, kidney calcification).

9. Release form

10. Storage conditions

11. Composition

1 tablet of Gastal:

• aluminum hydroxide-magnesium carbonate gel - 450 mg;
• magnesium hydroxide - 300 mg;
• Excipients: mannitol (E421), sorbitol (E420), lactose monohydrate, corn starch, sodium cyclamate, sodium saccharinate, talc, magnesium stearate, peppermint flavor.

12. Conditions for dispensing from pharmacies

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* Instructions for medical use of the drug Gastal are published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, YOU MUST CONSULT WITH A SPECIALIST

Perhaps each of us is familiar with discomfort in the stomach and intestines. In everyday life, we eat the wrong foods, our diet is completely unbalanced, and it often happens that we choose fast food as a snack. All this affects the condition of the gastrointestinal tract. In addition to poor nutrition, the gastrointestinal tract is affected by stressful situations, lifestyle, and bad habits. Many of us take Gastal for discomfort in the stomach or intestines. What does this pharmacological remedy help with?

Gastal belongs to the pharmacological group of antacid-type drugs. This pharmaceutical preparation contains substances that have a beneficial effect on the gastric mucosa, in particular:

• magnesium hydroxyate aluminum carbonate gel;
• magnesium hydroxide;
• additional substances.

When Gastal tablets enter the body, the active substances bind hydrochloric acid in the stomach, thereby eliminating discomfort and normalizing natural digestive processes. As practice shows, Gastal is most often taken by people who experience pain in the stomach after eating fatty or spicy foods, as well as from heartburn and after excessive alcohol consumption in order to remove toxins.

By binding free hydrochloric acid in the gastric cavity, Gastal helps to normalize the alkaline-acid balance, which allows you to get rid of painful and uncomfortable sensations. Often this drug is taken by people on a diet. If you are on a diet in order to lose excess weight, but by chance you have a breakdown and eat 1-2 cakes, then there is nothing wrong with that - you can take a Gastal tablet, which will allow you to digest the food you receive faster.

Indications for use of Gastal

As already mentioned, Gastal has a very good effect on the stomach, binding free hydrochloric acid. The pharmacological agent begins to act almost immediately after entering the digestive tract. The antacid-type effect lasts on average 2 hours. Thanks to its active substances, Gastal inhibits the production of a number of enzymes, in particular lysolecithin and pepsin, and also minimizes the effect of bile acid on the mucous membrane of the esophagus and stomach. According to the instructions, Gastal is recommended to be taken in the following cases:

• in case of gastritis of the hyperacid type;
• in case of detection of ulcerative pathologies of the stomach or duodenum;
• with diaphragmatic hernia;
• in case of belching or heartburn;
• in case of acute pancreatitis;
• in case of development of cholecystitis;
• with the development of erosive processes in the esophagus;
• with dyspepsia of the wandering type;
• in case of food or other poisoning;
• in case of gastroesophageal reflux pathology;
• in case of gastric retention syndrome.

As already mentioned, Gastal helps well with heartburn, as well as with alcohol intoxication. If a person experiences a hangover in the morning, then with the help of this pharmacological drug you can quickly get rid of toxins.

How to take Gastal?

Gastal can be purchased at any pharmacy. This pharmaceutical drug is available in tablet form. The dosage form of Gastal is the same, the difference is the flavoring additive and the number of tablets in the package. On pharmacy counters you can find packages containing 12, 24, 30 and 48 tablets. The most common Gastal tablets have no taste and are covered with a regular coating. But manufacturers also offer tablets with cherry and mint flavors. Most often, these pharmacological agents are purchased for children.

Before purchasing and taking Gastal, consult with your doctor, since this drug has a number of contraindications, and its excessive or improper use can lead to side effects. Please note the expiration date and release date. Gastal should be stored in a cool place, protected from children and direct sunlight. You should also observe the established temperature threshold for storing the drug. The course of treatment cannot exceed 14 days, since Gastal is taken exclusively for therapeutic purposes.

It is recommended to take the medicine one hour after a meal or one hour before bedtime. In any case, before starting a treatment course, it is best to consult a gastroenterologist. Adults are allowed to take 2 tablets no more than 3 times a day. Children aged 6 to 12 years are allowed to take no more than 1 tablet three times a day. Treating specialists do not recommend giving this drug to children under six years of age. There is no need to drink liquid or swallow a tablet. Its pharmacological form provides for resorption. The tablet should be placed behind the cheek or under the tongue: within a few minutes the active substances will begin to be absorbed into the mucous membrane and, together with the saliva produced, will enter the esophagus and stomach.

If heaviness and discomfort in the gastrointestinal tract are caused by overeating or drinking alcoholic beverages, then you can take one Gastal tablet. As practice shows, a person experiences relief after just a few minutes.

Contraindications for taking Gastal

If you carefully read the instructions for this pharmacological agent, you will familiarize yourself with the list of contraindications. So, Gastal is strictly forbidden to use in the following cases:

• with the progression of Alzheimer's disease;
• in case of individual intolerance to individual components, in particular lactose;
• in case of renal failure, when the pathology is severe;
• in case of an allergic reaction to the constituent components and active substances.

Gastroenterologists advise that elderly people, as well as women during pregnancy, should not take this drug. In practice, there have been cases when taking Gastal caused the appearance of diarrhea, constipation, nausea and changes in taste perception.

Side effects

Taking the pharmacological drug Gastal can also provoke the development of side effects. As a rule, they can occur with the wrong dosage or excessive use of tablets. Treating specialists and leading pharmacists identify the following side effects of the drug:

• nausea;
• manifestation of allergic reactions in various forms;
• development of osteoporosis;
• diarrhea;
• encephalopathy;
• constipation;
• disruption of normal kidney function;
• osteomalacia;
• nephrocalcinosis;
• hypercalciuria.

If Gastal is taken by people suffering from kidney failure, then as side effects they may experience an increase in blood pressure and constant thirst. In this case, you should immediately contact your treating specialist and undergo a full-scale study in order to prescribe a full and balanced treatment course.

In case of an overdose of Gastal, the above side effects may occur. It is better not to take Gastal with other medications at the same time. The interval between taking different pharmaceutical drugs should be at least 2 hours.

Gastal copes very well with various gastrointestinal diseases. The spectrum of pharmacological action of this drug is quite wide. Do not self-medicate. Only a specialist can prescribe a correct, balanced and effective treatment course.

Composition of mint or cherry lozenges:

• active ingredients: gel aluminum hydroxide - magnesium carbonate - 450 mg, magnesium hydroxide - 300 mg;
• Excipients: lactose monohydrate -112 mg; pregelatinized starch -32 mg; mannitol -112 mg; croscarmellose sodium -50 mg; colloidal silicon dioxide -2 mg; Magnesium stearate -6 mg; -2 mg; mint flavor (for mint tablets) - 6 mg; cherry flavor (for cherry tablets) - 4 mg.

Release form

Tablets intended for resorption (tasteless, mint or cherry) are white or close to white in color, round, smooth.

Regular tablets come in 6 pieces in a blister; 5, 2 or 10 such blisters in a cardboard box.

Blisters (also 6 tablets each) of cherry and mint Gastal are contained in a cardboard box in quantities of 4 and 8 pieces.

pharmachologic effect

Hastal has antacid effect .

Pharmacodynamics and pharmacokinetics

Gastal belongs to a group of drugs called buffered antacids . It increases the pH of gastric juice and eliminates discomfort caused by increased acidity (stomach pain, heartburn).

Antacid effect The drug is realized due to the neutralization of hydrochloric acid of the stomach, long-term and rapid effects. One tablet of Gastal is capable of neutralizing hydrochloric acid in an amount of 21.5 mmol.

Aluminum Hydroxide Magnesium Carbonate Gel - a buffer antacid substance, lowers the acidity of gastric juice to a level (pH 3-5) and normalizes the digestion process. inactivates pepsin contained in gastric juice.

Magnesium hydroxide - non-buffered antacid, not absorbed in the intestine. Quickly neutralizes acidity and has a laxative effect. Complex magnesium hydroxide And aluminum hydroxide ensures activation of the antacid effect and reduces the risk of side effects characteristic of each component separately (for example, after using aluminum compounds or after using magnesium compounds).

The antacid effect appears almost immediately after taking the Gastal tablet and lasts about two hours. The drug inactivates lysolecithin, pepsin And bile acids .

Aluminum hydroxide enhances regenerative and protective processes in the gastric mucosa. After interacting with hydrochloric acid stomach in an alkaline environment interacts with carbonates And phosphates . In the form of insoluble salts, it is excreted in the feces. Magnesium hydroxide after chemical transformations, it is also excreted in feces in the form of insoluble salts.

Indications for use of Gastal

Patients often ask the question, what does Gastal help with? In everyday language, pain and discomfort in the stomach are all things that Gastal tablets help with.

Clinical indications for the use of Gastal are:

• phenomena such as epigastric pain, discomfort, sour belching after drinking alcohol, coffee, errors in diet, nicotine, as well as those occurring after taking a number of medications;
• diseases characterized by increased acid formation: reflux esophagitis .

Contraindications

General contraindications for all forms of Gastal release:

• to connections magnesium, aluminum or other components of the drug;
• severe forms of renal failure;
• children under 6 years of age;
• hypophosphatemia ;
• diseases associated with metabolic disorders lactose .

The drug should be taken with caution in case of chronic kidney failure, adults and children over 12 years old weighing less than 50 kilograms, children from 6 to 12 years old.

Side effects

• From the stomach and intestines: nausea , vomit , change in color of stool.
• From the skin: sensitization reactions (, itching , And ).

• With long-term use of the drug in high doses, a decrease in concentration is possible phosphorus in the body, strengthening processes decalcification in bone tissue osteomalacia, hyperaluminemia, hypermagnesemia.
• In persons with kidney disease, plasma concentrations may increase aluminum And magnesium . This can lead to the development of and.
• Aluminum hydroxide dangerous for patients suffering porphyria and those passing by.

Instructions for use of Gastal

The instructions for use of Gastal prescribe how to take the drug in tablets with cherry and mint flavors and in regular tablets. Pregnancy and lactation are not strict contraindications for taking the drug.

Adults and children over 12 years of age weighing more than 50 kilograms are prescribed to dissolve 1 or 2 tablets 4-5 times a day, an hour after meals and before bedtime, the maximum daily dose is 8 tablets. The course of treatment should not be longer than 2 weeks.

With long-term use of large doses of Gastal, there may be hypocalcemia, hypophosphatemia, hypercalciuria, muscle weakness, fatigue, , osteomalacia, hyperaluminemia, hypermagnesemia, , nephrocalcinosis.

Signs of an overdose include exhaustion, facial flushing, and behavioral changes. It is also possible to develop m metabolic alkalosis, changes in mental activity, muscle pain, nervousness, fatigue, changes in taste sensitivity.

Treatment: discontinuation of the drug, gastric lavage, administration, in severe cases - rehydration, forced diuresis . In case of overdose in persons suffering from renal failure, it is necessary to carry out peritoneal dialysis or hemodialysis .

Interaction

There is a weakening of absorption from the gastrointestinal tract of drugs taken simultaneously with Gastal. Therefore, it is necessary to take a break between taking different medications.

Two hours before or two hours after taking Gastal you should take: H2-antihistamines, ethambutol, , anti-tuberculosis drugs, , chloroquine, cyclones, diflunisal, diphosphonates, fluoroquinolones, glucocorticoid drugs, kayexalate, lincosamides, lansoprazole, phenothiazines, antipsychotics, phosphorus, penicillamine, .

Gastal activates effects nalidixic acid And levodopa and slows down the action tetracyclines , drugs gland, , cardiac glycosides.

When using Gastal simultaneously with salicylates excretion of the latter by the kidneys increases.

The drug should not be used simultaneously with quinoline .

When used with quinidine its elimination is impaired, especially in persons with renal failure, and quinidine toxicity may develop.

Simultaneous use of Gastal and citrates leads to an increase in the level aluminum in blood.

The drug reduces adsorption.

Pirenzepine prolongs and enhances the action of Gastal.

Terms of sale

In most countries, the drug can be purchased without a prescription.

Storage conditions

Keep away from children. Store at a temperature not exceeding 25 degrees.

Best before date

special instructions

Aluminum hydroxide may cause , A magnesium hydroxide - intestinal hypokinesia. The use of Gastal in large doses can cause or intensify intestinal obstruction , especially in patients with renal failure or in the elderly.

It is necessary to consult a doctor if, after treatment, weight loss, persistent abdominal discomfort and difficulty swallowing, or indigestion become noticeable.

Connections aluminum are poorly absorbed in the intestine, but excessive or long-term use of the drug may lead to a decrease in concentration phosphates in the body, which is accompanied by an acceleration of processes resorption bones and the appearance hypercalciuria with increased risk osteomalacia .

Long-term use of Gastal in persons with renal failure leads to increased plasma concentrations aluminum And magnesium – this may be the reason for the development, , microcytic anemia .

The drug contains lactose , therefore, persons with congenital problems of sensitivity to galactose

The question is often asked, is it possible to use Gastal during pregnancy? During pregnancy, the instructions do not prohibit taking the drug, but this should be done with caution, after consulting a doctor.

It should be noted that the drug can affect intestinal motility: magnesium hydroxide may cause, and connections aluminum promotes development, which is often observed during pregnancy.

During treatment with Gastal, breastfeeding should be suspended.

Gastal- a combined antacid that reduces the increased acidity of gastric juice and does not have a stimulating effect on the secretion of gastric juice.

The drug Gastal suppresses the effect of pepsin, lysolecithin and bile acids, eliminates dyspeptic symptoms. Strengthens protective and regenerative processes in the gastric mucosa.

Pharmacological properties

Pharmacodynamics. Aluminum hydroxide-magnesium carbonate gel and magnesium hydroxide provide immediate (immediately after administration) and long-term (about 2 hours) neutralization of hydrochloric acid in gastric juice, maintaining acidity in the stomach at a physiological level (pH 3-5). One tablet of Gastal neutralizes 21.5 mmol of hydrochloric acid. Aluminum ions have a cytoprotective effect by increasing the secretion of mucin and sodium bicarbonate, activating prostaglandin E2 and NO, accumulating epidermal growth factor at the site of mucosal damage, and increasing the concentration of phospholipids in the walls of the stomach.

Pharmacokinetics. The drug Gastal does not have a systemic effect in patients with normal renal function. After interacting with hydrochloric acid of gastric juice, aluminum hydroxide reacts with phosphates and carbonates in the alkaline environment of the intestine and is excreted in the feces in the form of insoluble salts. Magnesium hydroxide reacts with hydrochloric acid in gastric juice to form magnesium chloride, which has osmotic properties and a mild laxative effect that neutralizes the fixing effect of aluminum hydroxide in the small intestine. Magnesium ions are excreted in the feces in the form of insoluble carbonate.

Indications for use of Gastal

Dyspeptic symptoms (after taking medications, alcohol, coffee, dietary errors, smoking); conditions accompanied by increased acid formation: peptic ulcer of the stomach and duodenum, gastritis; reflux esophagitis; hiatal hernia.

Directions for use and doses

Inside, gradually dissolving in the mouth. Adults and children over 12 years of age weighing at least 50 kg, 1-2 tablets 4-6 times a day, approximately 1 hour after meals and before bedtime, but not more than 8 tablets per day. Duration of treatment is no more than 2 weeks. Similar doses are recommended for the treatment of heartburn regardless of food intake. Adults and children over 12 years of age weighing less than 50 kg, children aged 6 to 12 years - the dose is half the recommended dose for adults and children over 12 years of age weighing at least 50 kg. Duration of treatment is no more than 2 weeks. Patients with chronic renal failure - no dose adjustment is required. Duration of treatment is no more than 2 weeks.

Features of application

The recommended dose and duration of treatment should not be exceeded when used in patients with impaired renal function. The use of the drug Gastal does not affect the ability to drive vehicles or control other mechanisms.

Side effects

Interaction with other drugs

The drug Gastal, when used simultaneously, enhances the activity of levodopa and nalidixic acid, reduces and slows down the absorption of quinolones, isoniazid, naproxen, iron preparations, indomethacin, aminazine, beta-blockers, diflunisal, H2-histamine receptor blockers, fat-soluble vitamins, indirect anticoagulants, barbiturates. When interacting with metal ions included in antacids, tetracyclines form insoluble chelate complexes; as a result of this interaction, the absorption of tetracyclines is reduced by more than 90%. The simultaneous use of these drugs is not possible. If combined use is necessary, tetracycline should be taken at least 2 hours before taking the antacid.

In the presence of aluminum and magnesium hydroxides contained in the antacid, the absorption of ciprofloxacin and ofloxacin is reduced by 50-90%. In the presence of antacids, the bioavailability of captopril is significantly reduced, and the combined use of antacids and metoprolol leads to a decrease in the concentration of metoprolol in the blood plasma. Concomitant use of high doses of antacids can reduce the absorption of ranitidine by 10-33%. The use of antacids does not affect the bioavailability of amoxicillin, cephalexin and the combination of amoxicillin and clavulanic acid, but can significantly reduce the absorption of doxycycline from the gastrointestinal tract.

An increase in urine pH during antacid therapy may increase the tubular reabsorption of basic (alkaline) drugs and reduce the reabsorption of acidic compounds. Antacids can reduce and slow down the absorption of salicylates, including acetylsalicylic acid, and also, by increasing the pH of urine, promote faster excretion of salicylates in the urine from the body, with a concomitant decrease in their concentration in the blood serum by 30-70%. The absorption of cardiac glycosides, including digoxin and digitoxin, is not significantly reduced when used simultaneously with antacids. M-anticholinergic blockers, by slowing down gastric motility, increase the duration of action of the drug Gastal®. In order to prevent possible interaction of the drug Gastal® with other drugs, it is recommended to take it 1 hour before or 1 hour after their use.

Contraindications

Hypersensitivity to aluminum, magnesium salts or other components of the drug; severe renal failure; Alzheimer's disease; hypophosphatemia; lactose intolerance, lactase deficiency or glucose-galactose malabsorption; children under 6 years of age. With caution in chronic renal failure (CRF), pregnancy and during breastfeeding, adults and children over 12 years old weighing less than 50 kg, children aged 6 to 12 years, old age.

Use during pregnancy and breastfeeding

The drug Gastal is not excreted in breast milk. When used during pregnancy and breastfeeding, it is necessary to evaluate the balance of benefit to the mother and risk to the fetus and infant.

Overdose

Symptoms of acute overdose are not described. With long-term use of high doses of drugs containing aluminum and magnesium, the development of hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesemia, hyperaluminemia, encephalopathy, nephrocalcinosis and impaired renal function is possible. It is possible to develop more pronounced adverse reactions from the gastrointestinal tract (gastrointestinal tract) (constipation, diarrhea), in patients with renal failure - thirst, decreased blood pressure, hyporeflexia. Treatment: symptomatic therapy.

Questions and answers on the topic "Gastal"

Question:When and in what dosage should Gastal be prescribed to patients?

Answer: Gastal should be prescribed internally for increased acidity of gastric juice, food poisoning and peptic ulcer of the duodenum and stomach, chronic and acute hyperacid gastritis (inflammatory process in the stomach as a result of a persistent increase in acidity). Due to the fact that this drug has the property of binding phosphates and delaying their absorption from the gastrointestinal tract, there is also its use for increased levels of phosphates in the blood (hyperphosphatemia), which accompanies renal failure. Dosage: This drug should be taken 4-6 times a day, 1-2 tablets (1 hour after meals). The tablets must be swallowed and not chewed under any circumstances.

Antacid drug

Active ingredients

Aluminum hydroxide magnesium carbonate gel
- magnesium hydroxide

Release form, composition and packaging

◊ Lozenges from white to cream color, round, with a smooth surface and a chamfer.

Excipients: (E421) - 120 mg, sorbitol (E420) - 50 mg, lactose monohydrate - 30 mg, corn starch - 75.8 mg, sodium cyclamate - 7 mg, sodium saccharinate - 0.2 mg, talc - 28 mg, magnesium stearate - 6 mg, peppermint flavoring - 3 mg.

6 pcs. - blisters (2) - cardboard packs.
6 pcs. - blisters (5) - cardboard packs.
6 pcs. - blisters (10) - cardboard packs.

pharmachologic effect

Combined antacid. Reduces the increased acidity of gastric juice and does not have a stimulating effect on the secretion of gastric juice.

Aluminum hydroxide-magnesium carbonate gel and magnesium hydroxide provide immediate (immediately after administration) and long-term (about 2 hours) neutralization of hydrochloric acid in gastric juice, maintaining acidity in the stomach at a physiological level (pH 3-5). 1 tablet of Gastal neutralizes about 21.5 mmol of hydrochloric acid.

Gastal suppresses the effect of pepsin, lysolecithin and bile acids, eliminates dyspeptic symptoms. Strengthens protective and regenerative processes in the gastric mucosa. Aluminum ions have a cytoprotective effect due to increased secretion of mucin and , activation of prostaglandin E2 and NO, accumulation of epidermal growth factor at the site of damage to the mucous membrane, and increased concentration of phospholipids in the stomach wall.

Pharmacokinetics

Gastal has no systemic effect in patients with normal renal function.

After interacting with hydrochloric acid of gastric juice, aluminum hydroxide reacts with phosphates and carbonates in the alkaline environment of the intestine and is excreted in the feces in the form of insoluble salts.

Magnesium hydroxide reacts with hydrochloric acid in gastric juice to form magnesium chloride, which has osmotic properties and a mild laxative effect that neutralizes the fixing effect of aluminum hydroxide in the small intestine. Magnesium is excreted in feces in the form of insoluble carbonate.

Indications

- heartburn and other dyspeptic symptoms (after taking medications, alcohol, coffee, dietary errors, smoking);

- conditions accompanied by increased acid formation: peptic ulcer of the stomach and duodenum, gastritis;

- reflux esophagitis;

- hiatal hernia.

Contraindications

- severe renal failure;

- Alzheimer's disease;

- hypophosphatemia;

- lactose intolerance, lactase deficiency or glucose-galactose malabsorption;

- children under 6 years of age;

- hypersensitivity to aluminum, magnesium salts or other components of the drug.

WITH caution The drug should be used for chronic renal failure, during pregnancy and during breastfeeding, in adults and children over 12 years of age weighing less than 50 kg, in children aged 6 to 12 years, in elderly patients.

Dosage

The drug is taken orally. The tablet should be dissolved gradually.

Adults and children over 12 years of age weighing at least 50 kg Prescribe 1-2 tablets. 4-6 times/day approximately 1 hour after meals and before bedtime, but not more than 8 tablets/day. Duration of treatment - no more than 2 weeks.

Adults and children over 12 years of age weighing less than 50 kg, children aged 6 to 12 years Prescribe half the recommended dose for adults and children over 12 years of age weighing at least 50 kg. Duration of treatment - no more than 2 weeks.

U patients with chronic renal failure no dose adjustment is required. Duration of treatment - no more than 2 weeks.

Side effects

From the digestive system: rarely (at least 0.01%, but less than 0.1%) - nausea, constipation, diarrhea, changes in taste.

Others: in exceptional cases - allergic reactions.

Overdose

Symptoms of acute overdose are not described.

Symptoms: with long-term use in high doses of drugs containing aluminum and magnesium, the development of hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesemia, hyperaluminemia, encephalopathy, nephrocalcinosis and impaired renal function is possible. Increased side effects from the digestive system (constipation, diarrhea) are possible. In patients with renal failure, thirst, decreased blood pressure, and hyporeflexia are possible.

Treatment: carrying out symptomatic therapy.

Drug interactions

Gastal, when used simultaneously, enhances the activity of levodopa and nalidixic acid, reduces and slows down the absorption of quinolones, naproxen, iron preparations, indomethacin, aminazine, beta-blockers, diflunisal, histamine H2 receptor blockers, fat-soluble vitamins, indirect anticoagulants, barbiturates.

When interacting with metal ions included in the composition, tetracyclines form insoluble chelate complexes; as a result of this interaction, the absorption of tetracyclines is reduced by more than 90%. The simultaneous use of these drugs is not possible. If combined use is necessary, it should be taken at least 2 hours before taking the antacid.

In the presence of aluminum hydroxide and magnesium hydroxide contained in the drug Gastal, the absorption of ciprofloxacin and ofloxacin is reduced by 50-90%.

In the presence of antacids, the bioavailability of captopril is significantly reduced, and the combined use of antacids and metoprolol leads to a decrease in the concentration of metoprolol in the blood plasma.

With the simultaneous use of antacids in high doses, the absorption of ranitidine may be reduced by 10-33%.

The use of antacids does not affect the bioavailability of amoxicillin, cephalexin and the combination of amoxicillin and clavulanic acid, but can significantly reduce the absorption of doxycycline from the gastrointestinal tract.

An increase in urine pH during antacid therapy may increase the tubular reabsorption of alkaline drugs and reduce the reabsorption of acidic compounds. Antacids can reduce and slow down the absorption of salicylates, incl. , and also, by increasing the pH of urine, promote faster excretion of salicylates in the urine from the body, with a concomitant decrease in their concentration in the blood serum by 30-70%.

Absorption of cardiac glycosides, incl. Digoxin and digitoxin, when used simultaneously with antacids, does not decrease significantly.

M-anticholinergic agents, by slowing down gastric motility, increase the duration of action of the drug Gastal.