Wobenzym diuretic effect. Wobenzym is a systemic enzyme therapy drug. Indications for use

Wobenzym is a specially created complex of biologically active enzymes of animal and vegetable origin. This complex of enzymes has strongly pronounced immunomodulatory, anti-inflammatory, anti-edematous and secondary analgesic properties. The enzymes included in the complex are necessary for the normal functioning of the body and are involved in almost all biological processes occurring in the body. If their number decreases, then this often leads to the emergence of various diseases. Wobenism has a positive effect on the inflammatory process, limits the manifestation of autoimmune processes, and is also able to influence the parameters of the body's immunological reactivity.

Wobenzym, composition and form of release

Wobenzym are enteric-coated tablets with an orange smooth surface and a specific odor. The tablet contains the following components:

Pancreatin (100 mg.);
- bromelain (45 mg.);
- papain (60 mg.);
- trypsin (24 mg.);
- amylase (10 mg.);
- chymotrypsin (1 mg);
- rutin (50 mg.);
- lipase (10 mg.)

In addition to the above components, there are other excipients in the composition: corn starch, lactose, magnesium stearate, talc, lactose, sucrose, colloidal silicon dioxide.

The number of tablets in a blister is 20 pieces. Available in packs of 40, 200 or 800 pieces.

Wobenzym: properties

The drug Wobenzym, the instruction to which is attached, has the following positive properties for the body:

Antiplatelet and fibrinolytic action;
- prevents the manifestation of autoimmune pathologies;
- increases the functionality of macrophages;
- contributes to the immunological activity of the body;
- stimulates the activity of T-lymphocytes, natural killers (NK-cells);
- stimulates the phagocytic activity of cells, which affects antitumor immunity;
- reduces the number of circulating immune complexes;
- reduces the infiltration of the interstitium with plasma cells;
- accelerates the process of decomposition of toxins;
- accelerates the process of resorption of hematomas and edema;
- increases the permeability of the walls of blood vessels, which leads to an increase in the rate of elimination of toxins from the body;
- regulates the adhesion of blood cells;
- normalizes density, viscosity and blood microcirculation;
- normalizes lipid metabolism;
- increases the amount of high density lipoproteins;
- reduces the synthesis of endogenous cholesterol;
- increases the concentration of antibiotics in the focus of infection processes;
- has the ability to reduce the negative effects caused by hormone therapy and antibiotic therapy;
- regulates the production of interferons;
- exhibits antiviral and antimicrobial activity;
- improves the absorption of polyunsaturated fatty acids.

Wobenzym: indications and use

As part of complex therapy or monotherapy, it is actively used in the following diseases:

Post-phlebitic syndrome, thrombophlebitis (including acute thrombophlebitis of superficial veins), lymphatic edema, obliterating endarteritis and atherosclerosis of the arteries of the lower extremities, prevention of recurrent phlebitis;
-prostatitis, cystitis, cystopyelitis;
- sexually transmitted infections;
- chronic infections of mastopathy, genitalia, gestosis, adnexitis, to reduce the frequency and severity of side effects of hormone replacement therapy in gynecology;
- angina pectoris, subacute stage of myocardial infarction (to improve the rheological properties of blood);
- sinusitis, bronchitis, pneumonia;
- pancreatitis, hepatitis;
-pyelonephritis, glomerulonephritis;
- diabetic angiopathy, diabetic retinopathy;
- autoimmune thyroiditis;
- rheumatoid arthritis, reactive arthritis, ankylosing spondylitis;
atopic dermatitis, acne;
-multiple sclerosis ;
- uveitis, iridocyclitis, hemophthalmos, use in ophthalmic surgery;
-treatment of postoperative complications (inflammatory processes, thrombosis, edema), adhesive disease, post-traumatic and lymphatic edema, plastic and reconstructive surgery;
- injuries, fractures, distortions, damage to the ligamentous apparatus, bruises, chronic post-traumatic processes, inflammation of soft tissues, burns, injuries in sports medicine.

Wobenzym: contraindications
- hemodialysis;
- age up to 5 years;
- poor blood clotting;
- hypersensitivity to components.

Wobenzym, instructions for use:

Wobenzym is used in doses from 3 to 10 tablets 3 times a day. The first days the drug is recommended to take 3 tablets 3 times a day, and further dosage depends on the severity of the disease and the individuality of the organism.

The average activity of the course of pathologies involves taking Wobenzym in the amount of 7-10 pieces 3 times a day for 2-3 weeks. Further, as a preventive measure, take 5 tablets 3 times a day for 2-3 months.

Long-term diseases that are chronic in nature suggest taking the drug for 3-6 months.
With a combination of Wobenzym and antibiotics, the drug is taken during the entire time of taking antibiotics, 5 tablets per day. Further, in order to restore the microflora of the stomach, Wobenzym should be taken 2-3 tablets 3 times a day for a course of 2 weeks.

During the period of chemotherapy or radiation therapy, Wobenzym is recommended to use the drug 3 times a day, 3-5 tablets throughout the course of oncology treatment.

For preventive purposes, Wobenzym is recommended to take 2-3 tablets three times a day for a month and a half. The course must be repeated twice or thrice a year.

For children over 12 years of age, the drug is recommended in the same doses as for adults: 3-5 tablets 3 times a day.

The instruction requires you to follow the rules of admission: take 30 minutes before meals and, without chewing, drink a glass of water.

Wobenzym side effects

The drug Wobenzym, reviews, the use of which indicates its good tolerability, although in some cases side effects may still be observed. With the appearance of diarrhea, nausea, vomiting, urticaria, the dose of the drug should be reduced.

With extreme caution, it is worth taking the drug to pregnant women, as well as with the complex use of the drug with drugs that reduce blood clotting.

Wobenzym: price and sale

The drug is widely distributed and is very popular. You can buy Wobenzym at any pharmacy, but this drug is different in that there are frequent cases of detecting counterfeit and counterfeit drugs. The drug Wobenzym, the price of which is almost the same everywhere, is better not to buy it from hand. It is worth making sure that there is a certificate of conformity of the goods, which can be provided at specialized points of sale of medicines.

The presence of side effects from taking the drug Wobenzym, reviews of which, in principle, are quite positive, require a doctor's consultation and familiarization with the manufacturer's annotation. Since this instruction is provided in free translation.

Wobenzym, the price of which is about 1,500 rubles for a package of 200 tablets, has its own permanent circle of consumers.

Wobenzym and Transfer Factor

Wobenzym must be taken for about 3 weeks in order to complete a course of therapy. Thus, the cost of treatment with this drug will be about 3,500 - 5,000 rubles, and the treatment may need to be repeated several times in order to achieve a result. The same functions as Wobenzym are also performed by the drug Transfer factor, which costs approximately 2000 rubles for a package of 90 capsules.

Transfer factor has no contraindications, but on the contrary, it is indicated for people of any age, patients with various diseases, and just people who want to take care of their health in advance. Transfer factor treatment is not accompanied by any side effects, is not addictive, and an overdose of this drug is also impossible.

In addition, Transfer Factor has a more dramatic effect on the human body and not only helps to cope with the disease, as other medicines do, but repairs damage to human DNA and restores the immune system. After all, malfunctions in the functioning of the immune system are the main reasons that various diseases occur in the body. Even if a decision is made to take Wobenzym, it is better to do it in combination with Transfer Factor, which is able to neutralize its negative effects on the body.

Instructions for use:

Wobenzym is a drug with anti-edematous, antiplatelet, anti-inflammatory, immunomodulatory and fibrinolytic effects.

Release form and composition

Wobenzym is produced in the form of enteric-coated tablets, red-orange, biconvex, round, with a characteristic odor and a smooth surface (20 pcs in blisters, 2 or 10 blisters in a carton box; 800 pcs in plastic bottles) .

The composition of 1 tablet includes active substances:

• Papain - 90 Federation International Pharmaceutical units (ED (FIP));
• Pancreatin - 345 proteolytic units of the European Pharmacopoeia (Prot. ED EF);
• Bromelain - 225 IU (FIP);
• Rutoside trihydrate - 50 mg;
• Lipase - 34 units (FIP);
• Trypsin - 360 units (FIP);
• Chymotrypsin - 300 IU (FIP);
• Amylase - 50 units (FIP).

Excipients that make up the preparation: resin, magnesium stearate, lactose monohydrate, macrogol 6000, corn starch, purified water, stearic acid, highly dispersed silicon dioxide, talc, sucrose, calcium carbonate, methacrylic acid and methyl methacrylate copolymer (1: 1), titanium dioxide, povidone, triethyl citrate, vanillin, bleach and carnauba wax, white, yellow-orange S (E110) and crimson 4 R (E124) dyes.

Indications for use

Wobenzym is prescribed in combination with other drugs in the treatment of the following diseases:

• Gastroenterology - hepatitis, chronic inflammatory diseases of the gastrointestinal tract, dysbiosis;
• Angiology - lymphatic edema, post-thrombophlebitic disease, thrombophlebitis, prevention of recurrent phlebitis, endarteritis and obliterating atherosclerosis of the arteries of the lower extremities;
• Dermatology - acne, atopic dermatitis, itchy dermatoses;
• Gynecology - chronic and acute infectious and inflammatory diseases of the genitals (cervicitis, salpingoophoritis, vulvovaginitis, endometritis), complex therapy for miscarriage of II-III trimesters, mastopathy, preeclampsia, a decrease in the severity and frequency of undesirable effects of hormone replacement therapy, sexually transmitted infections; in combination with antibiotics: ureaplasmosis, chlamydia, mycoplasmosis;
• Neurology - chronic disorders of cerebral circulation, multiple sclerosis;
• Cardiology - subacute stage of myocardial infarction, angina pectoris;
• Oncology - improving tolerance during chemotherapy and radiation therapy and reducing the risk of concomitant infectious complications;
• Nephrology - pyelonephritis, glomerulonephritis (simultaneously with antibiotics);
• Otorhinolaryngology - sinusitis, otitis, sinusitis, laryngitis (simultaneously with antibiotics);
• Pediatrics - atopic dermatitis, infectious and inflammatory diseases of the respiratory tract (pneumonia, inflammation of the upper and lower respiratory tract), treatment and prevention of postoperative complications (poor wound healing, suppuration and local edema, adhesive disease);
• Ophthalmology - glaucoma, iridocyclitis, uveitis, diabetic retinopathy, hemophthalmia, prevention of complications after surgery, ophthalmic surgery;
• Rheumatology - reactive arthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis;
• Pulmonology - tuberculosis, tracheobronchitis, bronchitis, obstructive bronchitis, pneumonia;
• Urology - prostatitis, cystopyelitis, cystitis, sexually transmitted infections (simultaneously with antibiotics);
• Traumatology - inflammation of soft tissues, chronic post-traumatic processes, injuries, injuries in sports medicine;
• Endocrinology - diabetic retinopathy, diabetic angiopathy, autoimmune thyroiditis;
• Dentistry - infectious and inflammatory diseases of the oral cavity;
• Surgery - prevention of postoperative complications (edema, thrombosis, inflammation), lymphatic and post-traumatic edema.

For prophylactic purposes, Wobenzym is prescribed according to indications:

• Vascular catastrophes, microcirculation disorders;
• Post-stress disorders, disruption of acclimatization and adaptation;
• Side effects of hormone replacement therapy;
• Development of viral infections and their complications;
• Dysbiotic disorders in the use of antibiotic drugs.

Contraindications

• Diseases associated with an increased likelihood of bleeding (thrombocytopenia, hemophilia);
• Carrying out hemodialysis;
• Children's age up to 5 years;
• Hypersensitivity to the components of the drug.

Method of application and dosage

Wobenzym is taken orally, at least 30 minutes before a meal or 2 hours after a meal, with water (150 ml). Tablets should not be crushed.

Usually, Wobenzym is prescribed for adults in the minimum therapeutic dose - 3 tablets 3 times a day for a course of 2-5 weeks.

With an average activity of the disease, taking 5 tablets 3 times a day is indicated, the duration of the course is 14-28 days. If there is an improvement in the condition, after 7 days from the start of therapy, a single dose can be reduced to 3 tablets. To achieve a long-term effect, it is recommended to conduct repeated therapeutic courses for 1.5-2 months after a 14-day break.

With high disease activity, the drug is taken 3 times a day, 7 tablets in a course of 21 days. In case of improvement in a week from the start of taking Wobenzym, a single dose is reduced to 3 tablets and the duration of the course is increased to 1.5 months.

With long-term chronic diseases, the drug is taken according to indications in courses of 3-6 months with interruptions of 14-28 days.

When carrying out planned operations, Wobenzym is used to prevent the occurrence of complications (adhesive disease, keloid scar, inflammation). The drug is started to be taken before surgery 3 times a day, 3 tablets in a course of 5 days. Therapy should be completed 3 days before the operation.

To increase the effectiveness of antibiotic drugs and reduce the severity of side effects, as well as to prevent dysbiosis, Wobenzym is prescribed for the entire course of antibiotic therapy 3 times a day, 5 tablets. To restore the intestinal microflora after the end of the course of antibiotic treatment, it is recommended to take the drug for 7-14 days, 3 tablets 3 times a day.

As a "cover" therapy during chemotherapy and radiation therapy to improve tolerance, prevent infectious complications and improve the quality of life, Wobenzym is prescribed 5 tablets 3 times a day until the end of the course of treatment. In the future, to restore immunity, the drug is taken for 21 days 3 times a day, 3 tablets.

With a preventive goal to increase resistance to diseases, the threshold of adaptation and reduce the risk of vascular accidents and diseases, Wobenzym is recommended to be taken in a course of 3-6 weeks, 2-3 tablets 3 times a day. The course can be repeated 2-3 times a year.

Children the drug is allowed from 5 years. Wobenzym is prescribed at the rate of 1 tablet per 6 kg of a child's weight, the frequency of administration is 2 times a day. The duration of the course is determined by the diagnosis and condition of the child and can vary from 2 to 5 weeks. Children from 12 years of age, the drug is prescribed in the same way as adults.

In the treatment of infectious diseases in children, Wobenzym is recommended to be taken simultaneously with antibiotics to increase their effectiveness during the entire course of therapy at a dosage determined according to the weight and age of the child.

To increase immunity and restore intestinal ecology after the end of etiotropic and antibacterial anti-infective treatment, the drug is taken 2 times a day, 1 tablet. For children over 12 years of age, a single dosage should be increased to 2 tablets. The recommended course is 7-21 days. The duration of the drug is determined by the doctor.

In case of recurrent inflammatory diseases in long-term and frequently ill children, Wobenzym is recommended to take 3-6 weeks 2 times a day, 2 tablets or in dosages calculated based on the weight and age of the child. To achieve improvement in the condition and stable remission in long-term and frequently ill children, it is recommended to conduct several repeated courses per year for 3-6 weeks with a break of 7-14 days. The duration of the drug and the dosage is determined by the doctor.

Side effects

Wobenzym is usually well tolerated, provided that the basic recommendations for its use are observed: the tablets should not be chewed, it is also necessary to observe the intervals between taking the drug and food (30 minutes before or 2 hours after a meal).

In some cases, during therapy, the development of such side effects as: minor changes in the smell and consistency of feces, vomiting, nausea, heaviness in the stomach, diarrhea, skin rashes in the form of urticaria, and allergies to the components that make up the drug were noted. These symptoms disappear when the dose is reduced or the drug is discontinued.

The syndrome of addiction and withdrawal was not detected even with prolonged therapy with high doses.

With the development of adverse reactions not noted in the instructions, it is recommended to cancel the treatment and consult a doctor.

special instructions

It should be borne in mind that at the beginning of taking Wobenzym, the symptoms of the disease may worsen. Interrupt treatment in such cases should not be, it is recommended to temporarily reduce the daily dose of the drug.

In infectious diseases, Wobenzym does not replace antibiotics, but increases their effectiveness by increasing their concentration in microbial colonies, tissues and inflammation.

The drug is not doping and does not have a negative effect on driving a car and performing work that requires a high speed of physical and mental reactions.

drug interaction

With the simultaneous use of Wobenzym with other drugs, cases of incompatibility are not described.

Analogues

Wobenzym's analogues are: Wobe-mugos E, Phlogenzym.

Terms and conditions of storage

Store in a dry place, out of the reach of children, at a temperature of 15-25 °C.

Shelf life - 2.5 years.

"Wobenzym", what does this decongestant immunomodulatory drug help with? The drug has fibrinolytic, anti-inflammatory and antiaggregatory effects. "Wobenzym" instructions for use prescribe to take as part of complex therapy for many diseases, including gastritis, dermatosis, infections and inflammation of the respiratory system.

Release form and composition

The medicine is produced in the form of tablets in packs of 40, 200 or 800 pieces. The active elements of the product are enzymes:

• rutoside;
• chymotrypsin;
• amylase;
• papain;
• pancreatin;
• lipase;
• bromelain;
• trypsin.

Instructions for use are included in the box with the preparation.

Pharmacology

The use of the drug "Wobenzym", from which the remedy helps for many indications, contributes to the rapid decomposition of necrotic tissues, the removal of toxins, the resorption of edema, and the improvement of the permeability of the capillary walls. The drug reduces the degree of negative effect on the body of medicinal hormones, increases the effect of the use of antibiotics, and normalizes the processes of reproduction of interferon. Wobenzym tablets, which are popular with many patients, help improve lipid metabolism, assimilate polyunsaturated fatty acids, nourish tissues and saturate them with oxygen.

Thanks to the drug, blood flow, blood viscosity and its rheological characteristics are significantly improved. The secondary analgesic effect of the drug is to influence the causes of the formation of acute inflammatory processes.

The medicine "Wobenzym": what helps

There is a long list of indications for which the drug is prescribed as part of complex therapy. What helps the medicine "Wobenzym"? The drug is used to treat the following conditions and pathologies:

• hepatitis, lymphedema, acne, cervicitis;
• miscarriage of II-III trimesters, cerebrovascular accident;
• pyelonephritis, atopic dermatitis, pneumonia, glaucoma;
• reactive arthritis, prostatitis, diabetic retinopathy;
• infections and inflammation of the oral cavity, edema, dysbiosis;
• post-thrombophlebitic disease, atopic dermatitis;
• salpingoophoritis, mastopathy, multiple sclerosis, glomerulonephritis;
• inflammation of the respiratory tract, iridocyclitis, rheumatoid arthritis;
• cystopyelitis, bronchitis, diabetic angiopathy, thrombosis;
• thrombophlebitis, itchy dermatoses, vulvovaginitis, ureaplasmosis;
• sinusitis, poor wound healing, uveitis, prevention of recurrent phlebitis;
• endometritis, chlamydia, subacute stage of myocardial infarction, otitis;
• suppuration, diabetic retinopathy, osteoarthritis, obstructive bronchitis;
• autoimmune thyroiditis, endarteritis, mycoplasmosis, angina pectoris;
• sinusitis, adhesive disease, hemophthalmia, tuberculosis, atherosclerosis obliterans;
• laryngitis, tracheobronchitis, cystitis, trauma, pneumonia;
• side effects of hormonal drugs, heart disease;
• conducting chemotherapy and radiation therapy.

• Tablets "Wobenzym": instructions for use

  The medicine is taken orally 30 minutes before meals with a sufficient amount of liquid. It is not recommended to crack the tablets. The treatment regimen is determined by a specialist depending on the clinical indications. Adult patients can be prescribed from 3 to 10 tablets three times a day. At the initial stages of therapy, 3 tablets are used three times a day.

  With moderate severity of pathologies, they drink up to 7 tablets 3 times within 2 weeks. Then continue treatment, taking up to 5 pieces for a month. In severe cases, in the first 2-3 weeks, up to 10 tablets are used, after which they switch to a dose of 5 pieces, taking them for 60-90 days. The medicine is used 3 times a day. During the treatment of chronic ailments, the remedy is taken from 3 to 6 months.

  With dysbacteriosis that has developed against the background of taking antibiotics, it is necessary to drink 3 tablets of Wobenzym three times a day for 2 weeks. For preventive purposes, the use of 5 capsules during the entire period of antibiotic treatment is indicated. Children "Wobenzym" is given based on their weight, the dosage is 1 tablet for every 6 kg of body weight.

Contraindications

The drug "Wobenzym" instructions for use prohibits taking with:

1. Individual intolerance to the composition.
2. Hemophilia.
3. thrombocytopenia.

Caution during treatment should be observed in pregnant women. Despite the fact that Wobenzym is not an antibiotic, its action increases the concentration of the active substances of these drugs in the area of ​​​​inflammation and blood plasma.

Enzyme deficiency leads to the development of multiple diseases and disorders of internal organs, but thanks to the drug Wobenzym, it is possible to restore and provide the human body with all organic substances. The composition of the drug contains all the necessary enzymes and other components to restore pathological manifestations or disorders. For a more detailed acquaintance with the drug, you need to read the instructions for use.

Instructions for use

The drug Wobenzym is produced in Germany by the pharmaceutical company MUCOS PHARMA.

Composition and form of release

Wobenzym is available in the form of orange-coloured enteric-coated tablets. The package contains tablets No. 40; No. 80; or No. 200. 1 tablet contains 250 mg of complex organic substances from pineapple and papaya plants, as well as enzymes from animal pancreas: pancreatin (15 mg); trypsin (24 mg); amylase (10 mg); rutin (50 mg); chymotrypsin (1 mg); lipase (10 mg); excipients: purified water, lactose, talc, magnesium stearate, silicon dioxide, corn starch, stearic acid, sucrose.

Pharmacological properties

Wobenzym contains highly active enzymes of animal and plant origin, has anti-inflammatory, immunomodulatory, fibrinolytic effects. Enzymes, which are part of the drug, take part in all biological and chemical processes, help to restore the body after chronic and infectious diseases and prevent their development.

Taking Wobenzym prevents the development of autoimmune diseases, increases the barrier functions of the body. It also has a positive effect on plasma cells, reducing their infiltration, and increases the elimination of protein detritus in the focus of inflammation, and also accelerates the healing process and lysis when exposed to toxic products on the body. Active substances, penetrating into the blood, promote the resorption of edema, hematomas, strengthen the walls of blood vessels.

When taking antibiotics, Wobenzym increases their concentration in the blood plasma, protects the intestines from the pathogenic effects of antibacterial drugs, prevents the development of dysbacteriosis, promotes the production of interferon, thereby providing an antimicrobial and antiviral effect. It improves the supply of oxygen and nutrients to the heart, tissues, which prevents the development of cardiovascular diseases and other disorders in the body.

Indications for use

• Gynecology: chronic infections, mastopathy, during pregnancy;
• Surgery: inflammatory postoperative complications, edema, acute and chronic thrombosis, plastic surgery;
• Pulmonology: acute, chronic bronchitis, bronchial asthma, sinusitis, pneumonia, diseases of the nasopharynx;
• Gastroenterology: gastritis, peptic ulcer, hepatitis, pancreatitis, ulcerative colitis;
• Traumatology: injuries of various nature, fractures, dislocations, bruises, inflammation of soft tissues;
• Neurology: treatment and prevention of neurological and psychological diseases;
• Nephrology: pyelonephritis, cystitis, urolithiasis, glomerulonephritis;
• Pediatrics: allergic reactions, dermatitis, eczema;

Contraindications

Wobenzym is generally well tolerated, but there are several contraindications:

• blood diseases with a risk for the development of bleeding;
• renal failure, hemodialysis procedures;
• age up to 5 years;
• hypersensitivity to the composition of the drug.

Mode of application

Wobenzym is prescribed by a doctor individually for each patient, depending on the disease, stage, course, localization.

Assign in a dose of 3 to 10 tab. 3 times a day. It is not allowed to independently increase the dose or amount of the drug. Preventive and maintenance dose should not exceed 3-5 tablets per day. The course of treatment is prescribed by a doctor. For children aged 5 to 12 years, the doctor prescribes 2-4 tablets. 3 times a day. For children over 12 years of age, Wobenzym is prescribed at the adult dose with a minimum number of tablets.

Side effects

The drug is well tolerated, only in some cases it is noted: digestive system disorders, nausea, allergic reactions. After feeling discomfort after taking the drug, it is recommended to consult a doctor. Before taking the drug, you need to consult a doctor. Do not self-medicate, which can be harmful to health or provoke complications.

Video

On the use of the drug in the treatment of cancer in the postoperative period.

Active substances:

Pancreatin 300 prot. - Europe. Pharm. - U, papain - 90 FIP-U, bromelain 225 FIP-U, lipase 34 FIP-U, amylase 50 FIP-U, trypsin 360 FIP-U, chymotrypsin 300 FIP-U, rutoside 50, 00 I Excipients:

Lactose, corn starch, magnesium stearate, stearic acid, purified water, colloidal silicon dioxide, talc.

Copolymer of metaacrylic acid - methyl methacrylate, talc, macrogol 6000, triethyl citrate, sucrose, calcium carbonate, titanium dioxide, povidone, white clay, vanillin, yellow-orange dye S (E 110), crimson dye 4 R (E 124), bleached wax, carnauba wax, shellac.

Description

Round biconvex tablets with a smooth surface, without cracks, with a characteristic light vanilla odor, orange-red in color. Fluctuations in the color intensity of the outer shell from orange-red to red are allowed.

Pharmacotherapeutic group

Other medicines used for disorders of the musculoskeletal system. Enzymes.

Code ATX: M09AB52

Pharmacological properties

Pharmacodynamics

Wobenzym is a preparation for oral administration containing lytic enzymes, mainly proteolytic ones - bromelain, papain, trypsin, chymotrypsin in combination with rutoside.

A mixture of enzymes, including bromelain and papain, helps to reduce edema of traumatic origin by enzymatic proteolysis in the interstitium of macromolecules of inflammatory mediators (histamine, etc.). In addition, microcirculation improves in the area of ​​damage due to lysis of fibrin and microthrombi, which helps to reduce edema. In laboratory animals (rats), the ability of the proteolytic enzymes that make up the Wobenzym preparation to inhibit platelet aggregation was demonstrated. In experimental and clinical models, the regulatory effect on the immune system of a mixture of proteases included in the preparation Wobenzym has been demonstrated.

Rutoside is a glycoside of the flavonoid quercetin, has P-vitamin activity. Helps reduce capillary permeability and fragility.

Pharmacokinetics

The mechanism of absorption of macromolecular substances, such as enzymes, by paracellular diffusion in the intestinal mucosa is described. There is also a breakdown of proteases in the intestine to amino acids. For bromelain and papain, the half-life is 5.5-8 hours and 36-48 hours, respectively. Rutoside appears to be rapidly metabolized after oral administration. Quercetin metabolites are determined in the blood: 3,4-dihydroxy-phenylacetic acid, 3,4-dihydroxytoluene, 3-hydroxy-phenylacetic acid and 3-methoxy-4-hydroxy-phenylacetic acid (homovanillic acid). After oral administration of rutoside, about 50% of its metabolites are excreted from the body within 48 hours in the urine.

Indications for use

Wobenzym is used as part of the complex therapy of inflammation, swelling and pain in:

trauma; thrombophlebitis; arthritis, including rheumatoid arthritis, and arthrosis.

Contraindications

Wobenzym should not be used

In case of hypersensitivity to active substances or to one of the other components; patients suffering from congenital or acquired blood clotting disorders, such as hemophilia; patients with severe liver and / or kidney disease; patients immediately prior to surgery

Use during pregnancy and lactation

Pregnancy and lactation are not a contraindication for the use of the drug, however, pregnant women should take Wobenzym under the supervision of a physician.

Dosage and administration

Tablets should be taken orally, at least 30 minutes before a meal or 90 minutes after a meal, without chewing, with water (200 ml).

adults

Depending on the activity and severity of the disease, Wobenzym is taken at a dose of 3 to 10 tablets 3 times a day. In the first three days of taking the drug, the recommended dose is 3 tablets 3 times a day.

With an average activity of the disease, Wobenzym is prescribed at a dose of 5-7 tablets 3 times a day for 2 weeks. In the future, the dose of Wobenzym should be reduced to 3-5 tablets 3 times a day, a course of 2 weeks.

With high disease activity, Wobenzym is prescribed at a dose of 7-10 tablets 3 times a day for 2-3 weeks. In the future, the dose of Wobenzym is reduced to 5 tablets 3 times a day, the course is 2-3 months.

In chronic long-term diseases, Wobenzym can be used according to indications in courses from 3 to 6 months or more.

The daily dose of Wobenzym should not exceed 30 tablets.

Treatment, as a rule, continues until the symptoms of the disease decrease.

Separate groups of patients

Dosage modification is not required in patients with mild or moderate hepatic and renal impairment. Wobenzym should not be taken in patients with severe hepatic and/or renal impairment.

In the elderly, a change in dosage is not required.

Children

There are no sufficient studies regarding the effect of the drug when taken by children and adolescents under 18 years of age with these indications.

Side effects

Wobenzym is well tolerated by patients. In most cases, side effects, withdrawal syndrome, addiction were not observed even with long-term treatment with high doses. In some cases, there are slight changes in the consistency and smell of feces, skin rashes in the form of urticaria, which disappear with a decrease in the dose of the drug or withdrawal. If other adverse reactions occur that are not noted in the instructions, it is recommended to stop taking the drug and consult a doctor.

Overdose

Cases of drug overdose are not known.

Interaction with other drugs

The study of interaction with other drugs has not been conducted.

With the simultaneous use of the drug Wobenzym and antibiotics, the level of antibiotics in plasma and urine, in particular, tetracyclines, sulfamids and amoxicillins, is increased.

Co-administration of Wobenzym with anticoagulants or inhibitors of platelet aggregation may increase the slowing down of blood clotting. Therefore, these medicines should be taken with Wobenzym strictly as directed and under close supervision.