Phosphogliv® (2.5 g) Phospholipids, glycyrrhizic acid trisodium salt. Phosphogliv (powder for solution for injection) Phosphogliv intravenously why is this drug prescribed

Phosphogliv is a domestic hepatoprotector, which is a combination of phospholipids (phosphatidylcholine) and glycyrrhizic acid. In addition to the hepatoprotective properties, the drug has a membrane-stabilizing and antiviral effect. Used in the treatment of viral hepatitis, hepatosis and other liver lesions, as well as skin diseases (psoriasis, eczema, etc.).

Chronic viral hepatitis is a pressing problem, both on a Russian and global scale. Vaccination can prevent acute hepatitis, but in the fight against chronic forms of this disease, it is, unfortunately, not so effective. Classic drug therapy for chronic hepatitis is a rather complex and expensive undertaking, motivating pharmacologists to create new, more effective drugs. One of these promising drugs is the drug phosphogliv, which, according to its creators, has no analogues on the global pharmaceutical market and is an absolute pioneer in many aspects. Thus, this is the only hepatoprotector that has both etiotropic and pathogenetic effects. The uniqueness of phosphogliv also lies in the combination of hepatoprotective and antiviral effects under the “roof” of one dosage form. One of the components of this drug - phosphatidylcholine - is endowed with the ability to structurally restore liver cells, acting like a “membrane sealant” that patches up holes in biological membranes. This pharmacologically active “ingredient” of phosphogliv is its main active principle, normalizing the metabolism of proteins and lipids and preventing the loss of enzymes by liver cells, restoring the detoxifying function of this organ. Phosphatidylcholine suppresses the excessive formation of connective tissue, which reduces the risk of developing hepatic fibrosis and cirrhosis, as well as improving the prognosis and increasing the quality of life of patients.

Another component of the drug is glycyrrhizic acid, a substance with antiviral activity that inhibits the reproduction of viruses in the body by activating the synthesis of interferons, stimulating the formation of phagocytes and the activity of natural killer cells. Being an antioxidant and exhibiting a membrane-stabilizing effect, glycyrrhizic acid potentiates the hepatoprotective effect of phospholipids and has anti-allergic and anti-inflammatory effects. The novelty of phosphogliv also lies in the unparalleled technology for creating a dry powder form of granular soy phospholipids. This made it possible to increase the shelf life of the capsulated dosage form. The original technology for producing a lyophilisate for intravenous administration made it possible to create a stable phospholipid nanosystem consisting of emulsified micelles and liposomes and free of toxic detergents (surfactants). Complex micelles can be stored in an active state for several years, which is of great clinical importance, because the patient in this case receives the active drug, and not the product of metabolic processes of pharmacologically active substances.

Phosphogliv has undergone a number of tests in leading Russian clinics. Its effect was assessed according to many criteria, including improvement in the patient’s general condition, elimination of symptoms of intoxication, disappearance of the yellow color of the skin, the presence/absence of bile in the stool, a decrease in the concentration of bilirubin and the activity of liver enzymes. As a result, all patients receiving phosphogliv showed positive dynamics. Thus, this drug has been demonstrated to be highly effective in treating liver diseases. It significantly improves the synthetic function of this organ and reduces the manifestations of liver failure. The drug is well tolerated and has a favorable safety profile.

Pharmacology

Combined drug. It has membrane-stabilizing, hepatoprotective and antiviral effects.

Phosphatidylcholine (the active substance of phospholipids) is the main structural element of cellular and intracellular membranes, capable of restoring their structure and function when damaged, providing a cytoprotective effect. Normalizes protein and lipid metabolism, prevents the loss of enzymes and other active substances by hepatocytes, restores the detoxifying function of the liver, inhibits the formation of connective tissue, reducing the risk of fibrosis and cirrhosis of the liver.

Glycyrate (glycyrrhizic acid and salts) has an anti-inflammatory effect, suppresses the reproduction of viruses in the liver and other organs by stimulating the production of interferons, increasing phagocytosis, and increasing the activity of natural killer cells. It has a hepatoprotective effect due to its antioxidant and membrane-stabilizing activity. Potentiates the effect of endogenous glucocorticosteroids, providing anti-inflammatory and antiallergic effects in non-infectious liver lesions.

In case of skin lesions, due to the membrane-stabilizing and anti-inflammatory effects of the components, it limits the spread of the process and promotes regression of the disease.

Pharmacokinetics

Suction

After oral administration, the components of the drug are well absorbed from the gastrointestinal tract both in the form of a whole molecule and in the form of bioactive hydrolysis products (unsaturated fatty acids, choline, glycerretic acid).

Distribution

Bioactive hydrolysis products are well distributed in the body, penetrating into the liver, lungs, skin and other organs.

Release form

Hard gelatin capsules, No. 0, with an orange body and a black cap; the contents of the capsules are granular powder from white with a slightly yellowish tint to light yellow, with a slight specific odor.

Excipients: microcrystalline cellulose, calcium carbonate, calcium stearate, talc, colloidal silicon dioxide (Aerosil).

Composition of the capsule body: titanium dioxide (E171), red iron oxide (E172), methyl parahydroxybenzoate (methylhydroxybenzoate), propyl parahydroxybenzoate (propylhydroxybenzoate), acetic acid, gelatin; or titanium dioxide (E171), red iron oxide (E172), gelatin.

Composition of the capsule cap: titanium dioxide (E171), black iron oxide (E172), methyl parahydroxybenzoate (methylhydroxybenzoate), propyl parahydroxybenzoate (propylhydroxybenzoate), acetic acid, gelatin; or titanium dioxide (E171), black iron oxide (E172), gelatin.

10 pieces. - contour cell packaging (2) - cardboard packs.
10 pieces. - contour cell packaging (3) - cardboard packs.
10 pieces. - contour cell packaging (5) - cardboard packs.
30 pcs. - plastic containers (1) - cardboard packs.
50 pcs. - plastic containers (1) - cardboard packs.
100 pieces. - plastic containers (1) - cardboard packs.
200 pcs. - plastic containers (1) - cardboard packs.
300 pcs. - plastic containers (1) - cardboard packs.

Dosage

Adults and children over 12 years of age are prescribed 1-2 capsules 3-4 times a day orally. Capsules are taken during meals with a small amount of liquid.

The drug is administered slowly IV 10 ml 2 times a day in the morning and evening for 10 days. The contents of 1 bottle must first be dissolved in 10 ml of water for injection, followed by switching to oral administration of the drug in capsule form.

Overdose

Currently, no cases of overdose of the drug Phosphogliv ® have been observed.

active ingredient: 1 bottle contains phospholipids (lipoids C 100) 500 mg, trisodium salt of glycyrrhizic acid (sodium glycyrrhizinate) 200 mg

excipients: maltose.

Dosage form

Lyophilisate for preparing a solution for intravenous administration.

Pharmacological group

Drugs used for liver diseases, lipotropic substances. Various drugs.

ATC code A05B A50 **.

Indications

Viral hepatitis (acute and chronic), steatohepatosis, steatohepatitis, other toxic liver damage, liver cirrhosis, intoxication, psoriasis.

Contraindications

Hypersensitivity to the components of the drug, pregnancy and lactation, age up to 12 years.

Directions for use and doses

Used intravenously in children over 12 years of age and adults, after dissolving the powder in 10 ml of water for injection. The introduction is carried out slowly. Administer 10 ml 2 times a day in the morning and evening for 10 days, followed by switching to oral administration of the drug in capsule form. The course of treatment may be increased by your doctor.

Adverse reactions

A skin rash may appear (with hypersensitivity), which disappears after discontinuation of the drug.

If the injection technique is not followed and the solution gets into the subcutaneous fatty tissue at the injection site, redness, swelling and pain are possible.

Overdose

Not noted.

Glycyrrhizic acid, which is part of the drug, in large doses can cause a pseudocorticosteroid effect, which consists of increasing the level of glucocorticoids and mineralocorticoids in the blood. This leads to sodium retention and a decrease in potassium in the body and, as a consequence, to increased blood pressure and water retention in the body.

When these symptoms appear, depending on the severity, it is necessary to reduce the dose of the drug and/or prescribe spironolactone 50-100 mg per day.

Use during pregnancy and lactation

Not used.

Children

For use in children aged 12 years and older.

Features of application

The drug is intended for intravenous administration only.

The prepared solution should be injected slowly into a vein. Use only water for injection as a solvent.

The ability to influence the reaction rate when driving vehicles or other mechanisms

Does not affect.

Interaction with other drugs and other types of interactions

The contents of the bottle must not be mixed with other solutions. For dissolution, use only water for injection. Do not use physiological sodium chloride solution or glucose solution to dissolve the drug.

Glycyrrhizic acid, which is part of the drug, is a synergist of corticosteroid hormones; it strengthens and continues their action.

Pharmacological properties

Pharmacodynamics. Combined remedy. It has membrane-stabilizing, hepatoprotective and antiviral effects.

Phosphatidylcholine (the main component of phospholipids) is the main structural element of cellular and intracellular membranes, capable of restoring their structure and function when damaged, exhibiting a cytoprotective effect. Normalizes protein and lipid metabolism, prevents the loss of hepatocyte enzymes and other active substances, restores liver function, inhibits the formation of connective tissue, reducing the risk of fibrosis and cirrhosis of the liver.

Glycyrrhizic acid has an anti-inflammatory effect, suppresses the reproduction of viruses in the liver and other organs by stimulating the production of interferons, increasing phagocytosis, and increasing the activity of natural killer cells. It has a hepatoprotective effect due to its antioxidant and membrane-stabilizing activity. Glycyrrhizic acid potentiates the effect of endogenous corticosteroids, exhibiting anti-inflammatory and antiallergic effects in non-infectious liver lesions.

In case of skin lesions, due to the membrane-stabilizing and anti-inflammatory effects of the components, it limits the spread of the process and promotes regression of the disease.

Pharmacokinetics.

Phospholipids. In plasma, phosphotidylcholine (a major component of phospholipids) and other phosphoglycerols are bound to lipoproteins and/or albumin. Phosphotidylcholine and other phosphoglycerols undergo the action of phospholipases, creating free fatty acids, choline and glycerol metabolites, which are again used for resynthesis of phosphotidylcholine in the liver and other organs. Thus, within a few hours after administration, phospholipids are mainly integrated with the phospholipids of the body through metabolic products. Their further excretion corresponds to the excretion of endogenous phospholipids and their metabolites.

Glycyrrhizic acid. The time during which a high concentration is maintained in plasma is 8-12 hours. Excreted in bile.

Basic physical and chemical properties

lyophilized mass from white to light yellow.

Incompatibility

The drug should not be mixed with other drugs. For dissolution, use only water for injection. Do not use physiological sodium chloride solution or glucose solution to dissolve the drug.

Best before date

Storage conditions

Store in a place protected from light and out of reach of children at a temperature not exceeding 20 ° C.

Package

Glass bottles of 2.5 g. 5 bottles in a cardboard box.

Vacation category

On prescription.

Manufacturer

JSC "Pharmstandard-UfaVITA".

Location

450077, Russian Federation, Ufa, st. Khudayberdin, 28.

Side effects of Phosphogliv occur infrequently.

Possible unwanted effects:

skin rash;
hypersensitivity reactions of the mucous membranes, manifested in the form cough , slight nasal congestion;
digestive disorders, belching , nausea , bloating ;
on peripheral parts of the body;
transient increase in blood pressure.

Instructions for use of Phosphogliv (Method and dosage)

Phosphogliv injections, instructions for use

Ampoules are prescribed to persons over 12 years of age.

The injection must be prepared by mixing the contents of the bottle with 10 ml of water and mixing thoroughly. Phosphogliv is administered intravenously in a dose of 10 ml. IV administration is carried out in the morning and evening.

The course of injections does not last long. In most cases, a transition to a capsule form of the drug is provided.

Instructions for use of capsules

Medicine in capsules is prescribed after reaching 12 years of age.

The drug is taken 1 or 2 capsules 3-4 times a day. Reception is carried out during meals. After drinking the medicine, you need to wash it down with water.

The course of treatment lasts up to six months. The average duration is 3 months.

Overdose

There are no reported cases of overdose.

Includes glycyrrhizic acid . If it enters the body in large quantities, it can have pseudocorticosteroid Effect. At the same time, the content of glucocorticoids and mineralocorticides in the blood increases. Because of this, sodium may be retained in the body and the amount of potassium may decrease. Clinically, such processes will be manifested by increased blood pressure, fluid retention, and swelling of the peripheral parts of the body.

Interaction

Glycyrrhizic acid interacts with corticosteroids. It is their synergist, that is, it enhances their effect and increases its duration.

Terms of sale

On prescription.

Storage conditions

Store in accordance with the storage requirements for drugs included in List B.

The storage location should be well protected from light.

The required temperature is up to 20°C.

Best before date

Capsules can be stored for 3 years, ampoules for 2 years.

special instructions

Caution should be exercised when treating patients diagnosed with portal or arterial hypertension . If your blood pressure increases as a result of taking Phosphogliv, you should stop therapy and consult your doctor.

The solution prepared on the basis of lyophilisate is strictly prohibited from being mixed with any other solutions for intravenous administration, including isotonic and glucose solutions.

For children

Allowed to be used only in the treatment of persons over 12 years of age.

With alcohol

Phosphogliv and alcohol have opposite effects on liver cells. Alcohol will slow down the regeneration of hepatocytes, and in large dosages it will destroy all the results of treatment.

But there is no interaction between alcohol-containing drinks and the active ingredients of the medicine, so a single dose of alcohol should not affect your well-being.

During pregnancy and lactation

Phosphogliv price, where to buy

In Russian pharmacies, the price of Phosphogliv in tablets (capsules) is approximately 500 rubles. The price of Phosphogliv in ampoules is 1500 rubles. In Ukraine, this medicine for the liver can be bought at a price of 215 hryvnia for capsules and 1,500 hryvnia for lyophilisate.

Online pharmacies in Russia Russia
Online pharmacies in Kazakhstan Kazakhstan

WER.RU

Phosphogliv lyophilisate bottle 2.5 g 5 pcs. + water for injection solvent 10 ml 5 pcs. Pharmstandard

Phosphogliv Forte capsules 50 pcs. Pharmstandard

Phosphogliv capsules 65+35 mg 50 pcs. Pharmstandard

Europharm * 4% discount using promo code medside11

Phosphogliv powder for injection 2.5 g 5 flPharmstandard-Ufa Vitamin Plant, O

Phosphogliv 50 capsPharmstandard-Leksredstva OJSC

Phosphogliv forte 50 capsPharmstandard-Leksredstva OJSC

Pharmacy Dialog * discount 100 rub. by promo code medside(for orders over 1000 rub.)

Phosphogliv (portion d/in. 2.5 fl. No. 5)

Phosphogliv forte (caps. No. 50)

Phosphogliv (porous d/in. 2.5 g fl. No. 5+ solution (packed contact layer))

Phosphogliv (caps. No. 50)

Pharmacy IFC

Author-compiler:- pharmacist, medical journalist Speciality: Pharmacist

Education: Graduated from Rivne State Basic Medical College with a degree in Pharmacy. Graduated from Vinnitsa State Medical University named after. M.I. Pirogov and internship at his base.

Experience: From 2003 to 2013, she worked as a pharmacist and manager of a pharmacy kiosk. She was awarded diplomas and decorations for many years of conscientious work. Articles on medical topics were published in local publications (newspapers) and on various Internet portals.

NOTE! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before using the drug Phosphogliv, be sure to consult with your doctor.

Anastasia Nalimova | 10:13 | 27.11.2017

After a course of antibiotics and a month spent in the hospital, I was finally discharged home. But, apparently, it was too early to rejoice. My liver started to feel very tight. Literally the next day I went to the doctor. She explained that the liver had suffered due to antibiotics and prescribed a hepatoprotector. I bought Phosphogliv at the pharmacy because it’s inexpensive and, according to the pharmacist, it should help well, because they sell it well. I bought it and took the course. Indeed, it has become easier. Control tests confirmed this.

Vita | 9:33 | 22.11.2017

It helps well with diet. When steatohepatitis was diagnosed, they immediately prescribed a diet and phosphogliv to prevent it from developing into fibrosis. For three months I took two capsules, three times a day. I felt an improvement in my condition already by the end of the first month of treatment, and at the end of the course my condition completely returned to normal.

Oleg | 11:05 | 16.10.2017

I live in Moscow. Thank you! I found cheap phosphogliv right in my area. 470 rubles each!!!

Roman | 8:12 | 16.10.2017

I agree with you, Ivan. If Phosphogliv had a large pack, it would be more convenient, and maybe cheaper, than the 50 pieces in which.

Ivan | 20:37 | 15.10.2017

Oleg, what region do you live in? If in Moscow, then I bought Phosphogliv capsules for 500 rubles using the Medlux website and looked for where it was more profitable. It's a pity that Phosphogliv doesn't have a big pack. The drug is good))

Svetlana | 22:26 | 12.10.2017

Oleg, what do you need – injections or encapsulated Phosphogliv? I remember at first I gave Phosphogliv injections. Expensive, of course, but wildly effective! In a couple of weeks everything improved almost to normal. I bought it at a social pharmacy and also at implosion at a discount. Look at the city information for prices.

Oleg | 21:38 | 10.10.2017

Tell me, I’m looking for where to buy Phosphogliv cheaper. They prescribed it for 3 months, the first one has already passed, it has become better, but it would take another 2 months to consolidate the effect. Where does anyone buy Phosphogliv?

Valentina I. | 18:42 | 31.08.2017

Against the background of diabetes mellitus, fatty liver degeneration appeared, I was prescribed Phosphogliv, after 3 months of treatment it brought my liver into full order, now I am more picky about food, I don’t want a recurrence of the disease.

Yana | 14:02 | 30.08.2017

Always when treated with antibiotics, I took beneficial bacteria, I was afraid of ruining the gastrointestinal tract, and as a result the liver suffered. Steatosis was diagnosed and I had to take phosphogliv for three months. I felt better after two months of taking it, and at the end of the course even the tests showed normal. Now during treatment I will take care not only of the gastrointestinal tract but also of the liver. Fortunately, phosphogliv is quite affordable.

Maria | 15:27 | 25.08.2017

I had an appointment to drink Phosphogliv because... Fatty hepatosis was suspected due to high weight. When they looked at Asat and Alat and did an ultrasound, that’s what it was – “fatty degeneration”. 10 days of injections and 4 months of capsules 2-3 times + giving up fatty foods and 10 thousand steps a day - and everything became normal.

Olga | 11:52 | 22.08.2017

Phosphogliv helped me with fatty liver. I took it 3 times a day, 2 capsules, for 3 months. Well, diet No. 5 with physical activity (walked 5-7 km a day).

Tolik | 18:46 | 14.07.2017

I liked Phosphogliv, it has an effect. I used to drink Essentiale, something became expensive, and I didn’t see any effect as such. The pharmacist recommended phosphogliv as an option. The composition is better, the price is 3 times lower.

Alice K. | 12:31 | 23.06.2017

For no apparent reason, I began to experience bouts of nausea. I thought it was poisoning, but when the attacks began to recur and were added to by aching pain on the right side, I ran to the doctor. After the examination, a preliminary diagnosis of NAFLD was made (the doctor felt that the liver was enlarged). Subsequently, ultrasound and biochemical analysis confirmed it. As a treatment, I drank phosphogliv, went on a diet, and went to group training in the pool. Three months later I took another test and had an ultrasound. According to the doctor, the condition of the liver has improved significantly, but it still has not fully recovered, it needs more time and constant monitoring.

Vitaly Abramov | 9:11 | 06.06.2017

It is not clear how I developed my degree of fibrosis. More precisely, it is clear that it was because of alcohol, but I didn’t drink that much, but every day, after work. But somehow it all happened quickly. The treatment is simple - complete abstinence from alcohol (coded) and several packs of Phosphogliv. The doctor seemed to reassure me that fibrosis is reversible and the liver is recovering. As a result, now I haven’t been drinking at all for two months, I go in for sports whenever possible and drink phosphogliv, the course is designed for six months. Control tests will be done in a month, we’ll see what the tests show. I’ll post the results here separately.

Olga Skuratova | 18:35 | 20.05.2017

I went to see a doctor because my liver was seriously bothering me - I felt nauseous, there was pressure on the side on the right side, under the ribs. It was a big discovery that there is such a diagnosis as fatty liver. If you follow simple rules: nutrition, active lifestyle, there will be no problems with the liver. But she also had to undergo treatment; she took Phosphogliv, a drug to restore liver function. I began to feel better closer to the middle of the course.

Mikhail | 22:40 | 15.05.2017

I worked for an artificial flavor company. And to be honest, I got a job there out of stupidity, because the enterprise did not follow basic safety rules, there weren’t even gowns. When I left work, I smelled these fragrances a kilometer away; my family asked me to find another job, because even my clothes could not be washed from this smell. In the end, I quit my job because I realized that it was seriously undermining my health. I literally felt nauseous from the smell at work, and then my right side began to ache. When I went to the doctor, it turned out that the production was toxic and affected the liver, the tests were not very good. The doctor prescribed me to take Phosphogliv, which I took for 3 months and the discomfort began to slowly go away. Now they don't bother me anymore.

Valeria | 9:53 | 25.04.2017

I really like Phosphogliv, not only for its natural composition, but also for its inexpensive price. The first time I learned about it was when it was prescribed for the treatment of dermatitis. I always thought that dermatitis could be treated with ointments, but it turned out that in complex treatment with a hepatoprotector, you can not only get rid of dermatitis, but also consolidate the result for a long time. I was treated for three months, by the end of the second month of treatment, the spots on the skin disappeared, and by the end of the treatment there were no signs of the disease at all. Control blood tests showed good results

Oleg | 13:42 | 06.04.2017

I went to the doctor when I felt that my performance had dropped greatly and I began to get tired quickly. The neurologist sent me for an MRI of the brain, but it didn’t reveal anything. He took biochemistry tests, which showed an excess of liver enzymes in the blood. Tests were sent to a gastroentrologist. After an ultrasound, the final diagnosis was made - fibrosis f2. They prescribed diet No. 5, folic acid, Phosphogliv in a course of 3 months - 3 times a day, 2 capsules with meals and an active lifestyle. I diligently followed all the doctor's instructions. Two months have passed, tests show that I am slowly but surely coming to my senses. I even feel it in my general health; I have become much more active.

Mila | 23:10 | 31.03.2017

Long-term drug treatment seriously affected the liver. The symptoms manifested themselves as heaviness on the right side, in the liver area, loss of appetite and nausea rolling in waves. The doctor prescribed a diet and a course of phosphogliv. After three months of treatment, all symptoms went away, my health improved, and my tests became good. I thought that the treatment was a little expensive, but it turned out that the drugs in this category are not cheap.

Ilya | 16:40 | 23.03.2017

The drug Phosphogliv supports the liver very well. It happens that I can abuse alcoholic beverages and after such binges I feel, to put it mildly, not very well. To help the liver, I try not to forget about taking this drug - it becomes much easier.

Elena | 23:51 | 19.02.2017

I took Phosphogliv in a course during the New Year holidays, to support the liver, from “gastronomic Armageddon”. Just recently I was treated with antibiotics, and my liver began to bother me, and there were still two weeks of holidays ahead. It’s clear that no one will stick to the diet at this time, so I started taking Phosphogliv. Helped great. Although the course of treatment is not completed yet, there is nothing to worry about. Prevention turned out to be very effective.

Evgenia | 22:03 | 14.02.2017

In recent months, I have increasingly begun to experience heaviness in the right hypochondrium and general weakness of the body. An ultrasound revealed minor diffuse changes in the liver and an increase in its size. Treatment was prescribed: three months, three times a day, 2 capsules of Phosphogliv. There is still a week left before the end of the course, but I already feel good, there are no signs or even hints that I have liver problems. The only trouble is steamed food, which I can't stand. But for the sake of health, you have to endure.

Veselova | 19:13 | 22.01.2017

For two months I drank Phosphogliv prescribed by my doctor. I can say that he helped me. I haven’t gone for a repeat test yet, but the result is obvious, or rather on the face. The dermatitis that tormented me went away, no spots or marks remained on the skin.

Ulyana | 8:49 | 16.01.2017

Acne appeared all over my body and on my face, I don’t know why, it seemed like I had left adolescence a long time ago. I went to see a dermatologist, and he redirected me to see a therapist to check my liver. It turned out that the problem with the liver caused skin rashes. I periodically felt heaviness in my right side, but in no way connected it with acne. I could drink a decoction of chicory herb and for a while the heaviness disappeared. But weed did not turn out to be a solution to the situation. Complete recovery was achieved by treatment with Phosphogliv. The treatment turned out to be far from budgetary (a little more than 5,000 rubles), but most importantly, effective. I solved two problems at once: I cleaned my liver and cleared my skin of rashes.

| 01.11.2016

I bought it for treatment for my mother, three years ago she suffered from jaundice, and since then the liver has periodically reminded itself of itself. At first they bought expensive medications, and then I bought her Phosphogliv, on the doctor’s advice. We took it for a course of three months, this treatment was enough for a year, of course I make sure that my mother does not get carried away with gastronomic excesses, and we like the result. She feels well, tests for AST and ALT levels are good and stable.

Lisa | 23:26 | 27.10.2016

When problems with my health began (heartburn, heaviness in the right hypochondrium), I had to go for an examination. The doctor said problems with the liver (enlargement) and gallstones. They prescribed the combined use of Ursa and Phosphogliv for the liver, as well as a diet. After the first course of treatment, I felt relief, the levels of AST and ALT returned to normal. Six months later, the doctor recommended re-treatment to consolidate the results.

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Active ingredients

Sodium glycyrrhizinic acid
- phospholipids

Release form, composition and packaging

Lyophilisate for preparing a solution for intravenous administration in the form of a mass from white to light yellow.

2.5 g - glass bottles (5) complete with water diluent (amp. 10 ml 5 pcs.) - contour plastic packaging (1) - cardboard packs.

pharmachologic effect

Combined drug.

It has membrane-stabilizing, hepatoprotective and antiviral effects.

Phosphatidylcholine(the main component of phospholipids) is the main structural element of cellular and intracellular membranes, capable of restoring their structure and function when damaged, providing a cytoprotective effect. Normalizes protein and lipid metabolism, prevents the loss of enzymes and other active substances by hepatocytes, restores the detoxifying function of the liver, inhibits the formation of connective tissue, reducing the risk of fibrosis and cirrhosis of the liver.

Glycyrrhizic acid has an anti-inflammatory effect, suppresses the reproduction of viruses in the liver and other organs by stimulating production, increasing phagocytosis, and increasing the activity of natural killer cells. It has a hepatoprotective effect due to its antioxidant and membrane-stabilizing activity. Potentiates the effect of endogenous glucocorticoids, providing anti-inflammatory and effect on non-infectious liver lesions.

In case of skin lesions, due to the membrane-stabilizing and anti-inflammatory effects of the components, it limits the spread of the process and promotes regression of the disease.

Indications

— viral hepatitis (acute and chronic);

— fatty liver degeneration (hepatosis);

- other liver damage (drug, alcohol, toxic);

- intoxication;

- psoriasis;

— neurodermatitis;

- eczema.

Contraindications

- pregnancy;

- lactation period (breastfeeding);

- children under 12 years of age;

- hypersensitivity to the components of the drug.

Dosage

Adults and children over 12 years old: IV, after dissolving the powder in 10 ml of water for injection. IV administration should be done slowly. Administer 10 ml daily 2 times a day in the morning and evening for 10 days, followed by switching to oral administration of the drug in capsule form. The duration of the course can be increased on the recommendation of a doctor.

Side effects

For the skin and subcutaneous tissues: with increased individual sensitivity, it may appear, which disappears after discontinuation of the drug.

If the daily dose is exceeded: possible sodium and fluid retention, edema, increased blood pressure, hypokalemia. If these symptoms appear, depending on their severity, it is necessary to reduce the dose of the drug and/or prescribe spironolactone 50-100 mg/day.

Drug interactions

The contents of the bottle must not be mixed with other solutions.

Use only for dissolution.

Do not use physiological sodium chloride solution or glucose solution to dilute the drug.

Capsules, lyophilisate for the preparation of solution for intravenous administration

Hard gelatin capsules No. 0, capsule body – orange, cap – black. The contents of the capsule are granular powder from white with a slightly yellowish tint to light yellow, with a slight specific odor.

30, 50, 100, 200 or 300 capsules in plastic containers with high-density polyethylene or propylene lids.

10 capsules per blister pack made of polyvinyl chloride film and aluminum foil.

1 container or 2, 3, 5 strip packaging along with instructions for use are placed in a cardboard pack.

Lyophilisate in packaging of 5 and 10 bottles.

Composition and active substance

Phosphogliv contains:

Phosphogliv Capsules

1 capsule contains:

Active ingredients: Phospholipids (Lipoid C 80) (calculated as 100% substance) (main component phosphatidylcholine 73-79%) - 65 mg, sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) - 35 mg.

Excipients: microcrystalline cellulose - 141.2 mg, calcium carbonate - 204.7 mg, calcium stearate - 0.9 mg, talc - 7.7 mg, colloidal silicon dioxide (Aerosil) - 5.5 mg, hard gelatin capsules - 96.0 mg [body: sunset yellow dye (E110) - 1.0%, titanium dioxide (E171) - 1.0%, gelatin - up to 100.0% cap: titanium dioxide (E171) - 0.2% , iron dye black oxide (E172) - 3.5%, gelatin - up to 100.0%].

Phosphogliv forte capsules

1 capsule forte contains:

Active ingredients: lipoid PPL-400 400 mg, phospholipids (main component - phosphatidylcholine 73-79%) 300 mg, sodium glycyrrhizinate 65 mg

Excipients: butylated hydroxytoluene, ethanol (luxury or extra grade), sunflower oil or corn oil

Composition of the capsule shell: titanium dioxide, red iron oxide dye, black iron oxide dye, yellow iron oxide dye, gelatin.

Phosphogliv Lyophilisate for the preparation of solution for intravenous administration

1 bottle of lyophilisate contains:

Active ingredients: phospholipid - 500 mg, glycirate - 200 mg.

pharmachologic effect

Combined remedy. It has membrane-stabilizing, hepatoprotective and antiviral effects.

Glycyrrhizic acid has an anti-inflammatory effect, suppresses the reproduction of viruses in the liver and other organs by stimulating the production of interferons, increasing phagocytosis, and increasing the activity of natural killer cells. It has a hepatoprotective effect due to its antioxidant and membrane-stabilizing activity. Potentiates the effect of endogenous glucocorticosteroids, providing anti-inflammatory and antiallergic effects in non-infectious liver lesions.

In case of skin lesions, due to the membrane-stabilizing and anti-inflammatory effects of the components, it limits the spread of the process and promotes regression of the disease.

Pharmacokinetics.

Phosphatidylcholine

More than 90% of phospholipids taken orally are absorbed in the small intestine. Most of them are cleaved by phospholipase A to 1-acetyl-lysophosphatidylcholine, 50% of which is reverse acetylated into polyunsaturated phosphatidylcholine during absorption in the intestinal mucosa. Polyunsaturated

Phosphatidylcholine enters the bloodstream through the lymph, from where it mainly enters the liver in the form associated with high-density lipoproteins. Pharmacokinetics in humans was studied using radiolabeled dilenoleyl phosphatidylcholine - 3H (choline moiety) and 14C (linoleic acid moiety). The maximum concentration of 3H is achieved after 6-24 hours, amounting to 19.9% of the prescribed dose; 14C - after 4-12 hours, amounting to 27.9%. The half-life of the choline component is 66 hours, the linoleic acid residue is 32 hours. In feces, 2% 3H and 4.5% - 14C are found in urine - 6% 3H and a minimal amount of 14C. Both isotopes are absorbed in the intestine by more than 90%.

Glycyrrhizic acid

After oral administration in the intestine, under the influence of the enzyme β-glucuronidase, produced by bacteria of normal microflora, an active metabolite is formed from glycyrrhizic acid - β-glycyrrhetic acid, which is absorbed into the systemic circulation. In the blood, β-glycyrrhetic acid binds to albumin and is almost completely transported to the liver. The excretion of β-glycyrrhetic acid occurs predominantly in bile, with residual amounts in urine.

According to experimental data, phospholipids improve the lipophilic properties of glycyrrhizic acid, increasing the intensity and rate of its absorption by more than 2 times.

What does Phosphogliv help with: indications

— Fatty liver degeneration (hepatosis), alcohol, toxic, including drugs, liver damage

— As part of complex therapy for viral hepatitis (acute and chronic), liver cirrhosis and psoriasis.

Contraindications

Hypersensitivity to glycyrrhizic acid, phosphatidylcholine or other components of the drug

Antiphospholipid syndrome

Pregnancy (insufficient data on efficacy and safety)

Breastfeeding period (data on effectiveness and safety are insufficient)

Children under 12 years of age (data on effectiveness and safety are insufficient).

Phosphogliv during pregnancy and breastfeeding

The drug is contraindicated for use during pregnancy and lactation.

Phosphogliv: instructions for use

Capsules

Take orally during meals, without chewing, with a small amount of liquid.

Lyophilisate

The injection solution is administered intravenously by first dissolving 2.5 g (1 bottle) of dry lyophilized powder in 10 ml of pyrogen-free water (water for injection).
In the acute form of the disease, the drug is administered 1 or 2 times a day for 10-30 days, in the chronic form, 1 time every other day or 3 times a week for 6-12 months. After completing the intravenous course, therapy can be continued with Phosphogliv in capsules - 2 capsules 3 times a day for 30 days in acute and 6-12 months in chronic forms of the disease.

Side effects

Allergic reactions: skin rash, difficulty in nasal breathing, conjunctivitis, cough.

From the cardiovascular system: transient (transient) increase in blood pressure, peripheral edema.

If these symptoms occur, you should stop taking the drug and consult your doctor.

special instructions

In patients with portal hypertension. In patients with arterial hypertension. If you have these diseases, you should consult your doctor before starting to take the drug.

If your blood pressure increases, you should stop taking the drug and consult a doctor.

The drug does not have a negative effect on the ability to drive vehicles and perform other work that requires increased concentration and speed of psychomotor reactions.

Compatibility with other drugs

Not described.

Overdose

Not described.

Storage conditions and shelf life

Store at a temperature not exceeding 25 °C. Keep out of the reach of children.